drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01222 | DB11248 | 617 | 1,193 | [
"DDInter246",
"DDInter1965"
] | Budesonide | Zinc gluconate | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA . It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration of common colds and wi... | Minor | 0 | [
[
[
617,
23,
1193
]
],
[
[
617,
24,
1531
],
[
1531,
23,
1193
]
],
[
[
617,
40,
167
],
[
167,
23,
1193
]
],
[
[
617,
24,
270
],
[
270,
... | [
[
[
"Budesonide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
]
],
[
[
"Budesonide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
],
[... | Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab and Canakinumab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate
Budesonide (Compound) resembles Hydrocortisone (Compound) and Hydrocortisone may cause a minor interaction t... |
DB00976 | DB01105 | 1,056 | 222 | [
"DDInter1758",
"DDInter1665"
] | Telithromycin | Sibutramine | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
1056,
24,
222
]
],
[
[
1056,
6,
8374
],
[
8374,
45,
222
]
],
[
[
1056,
21,
28852
],
[
28852,
60,
222
]
],
[
[
1056,
24,
384
],
[
384,
... | [
[
[
"Telithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Telithromycin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Comp... | Telithromycin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sibutramine (Compound)
Telithromycin (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Sibutramine (Compound)
Telithromycin may cause a moderate interaction that could exacerbate diseases when taken with Idelal... |
DB00495 | DB00959 | 139 | 1,486 | [
"DDInter1961",
"DDInter1191"
] | Zidovudine | Methylprednisolone | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain... | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Moderate | 1 | [
[
[
139,
24,
1486
]
],
[
[
139,
24,
175
],
[
175,
40,
1486
]
],
[
[
139,
24,
167
],
[
167,
1,
1486
]
],
[
[
139,
63,
251
],
[
251,
1... | [
[
[
"Zidovudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Zidovudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
... | Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles ... |
DB06754 | DB09068 | 707 | 1,427 | [
"DDInter471",
"DDInter1948"
] | Danaparoid | Vortioxetine | Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans. The active constituents are heparan, dermatan and, and they are isolated from the porcine intestinal mucosa [FDA Label]. Danaparoid possesses a potent antithrombic activity tha... | Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin r... | Moderate | 1 | [
[
[
707,
24,
1427
]
],
[
[
707,
64,
256
],
[
256,
24,
1427
]
],
[
[
707,
25,
365
],
[
365,
24,
1427
]
],
[
[
707,
25,
405
],
[
405,
... | [
[
[
"Danaparoid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vortioxetine"
]
],
[
[
"Danaparoid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prasugrel"
],
[
"Prasugrel... | Danaparoid may lead to a major life threatening interaction when taken with Prasugrel and Prasugrel may cause a moderate interaction that could exacerbate diseases when taken with Vortioxetine
Danaparoid may lead to a major life threatening interaction when taken with Dalteparin and Dalteparin may cause a moderate inte... |
DB00041 | DB00722 | 1,648 | 743 | [
"DDInter38",
"DDInter1079"
] | Aldesleukin | Lisinopril | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction.[L8384,L8387,L8390] Lisinopril and [captopril] are the only ACEIs that are not prodrugs. It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldos... | Moderate | 1 | [
[
[
1648,
24,
743
]
],
[
[
1648,
24,
610
],
[
610,
40,
743
]
],
[
[
1648,
24,
1638
],
[
1638,
1,
743
]
],
[
[
1648,
24,
384
],
[
384,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisinopril"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enalapril"
],
[
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Enalapril and Enalapril (Compound) resembles Lisinopril (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril and Trandolapril (Compound) resembles Lisinopril (Compou... |
DB00712 | DB09418 | 1,274 | 554 | [
"DDInter763",
"DDInter1501"
] | Flurbiprofen | Potassium perchlorate | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Potassium perchlorate is an inorganic salt with the chemical formula KClO4. It is a strong oxidizer with the lowest solubility of the alkali metal perchlorates. Potassium is most commonly used in flares and automobile airbags . The use of potassium perchlorate as a component in sealing gaskets for food containers has b... | Moderate | 1 | [
[
[
1274,
24,
554
]
],
[
[
1274,
24,
935
],
[
935,
24,
554
]
],
[
[
1274,
64,
886
],
[
886,
24,
554
]
],
[
[
1274,
63,
598
],
[
598,
... | [
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Potassium perchlorate"
]
],
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
... | Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen may cause a moderate interaction that could exacerbate diseases when taken with Potassium perchlorate
Flurbiprofen may lead to a major life threatening interaction when taken with Ketorolac and Ketorol... |
DB00612 | DB00816 | 1,121 | 1,674 | [
"DDInter216",
"DDInter1346"
] | Bisoprolol | Orciprenaline | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Moderate | 1 | [
[
[
1121,
24,
1674
]
],
[
[
1121,
24,
874
],
[
874,
24,
1674
]
],
[
[
1121,
63,
1636
],
[
1636,
24,
1674
]
],
[
[
1121,
6,
3576
],
[
3576,... | [
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orciprenaline"
]
],
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
],
... | Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Orciprenaline
Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine an... |
DB00405 | DB01215 | 128 | 1,418 | [
"DDInter517",
"DDInter677"
] | Dexbrompheniramine | Estazolam | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam. | Moderate | 1 | [
[
[
128,
24,
1418
]
],
[
[
128,
63,
523
],
[
523,
1,
1418
]
],
[
[
128,
24,
1216
],
[
1216,
40,
1418
]
],
[
[
128,
63,
905
],
[
905,
... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estazolam"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alprazolam"
... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Alprazolam and Alprazolam (Compound) resembles Estazolam (Compound)
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Flurazepam and Flurazepam (Compound) resembles Estazol... |
DB00006 | DB00814 | 942 | 1,171 | [
"DDInter217",
"DDInter1143"
] | Bivalirudin | Meloxicam | Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important t... | Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is ... | Moderate | 1 | [
[
[
942,
24,
1171
]
],
[
[
942,
24,
1027
],
[
1027,
40,
1171
]
],
[
[
942,
25,
1046
],
[
1046,
63,
1171
]
],
[
[
942,
24,
366
],
[
366,
... | [
[
[
"Bivalirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meloxicam"
]
],
[
[
"Bivalirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Piroxicam"
],
[
... | Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Piroxicam and Piroxicam (Compound) resembles Meloxicam (Compound)
Bivalirudin may lead to a major life threatening interaction when taken with Caplacizumab and Caplacizumab may cause a moderate interaction that could exacerbate ... |
DB00158 | DB00593 | 356 | 1,464 | [
"DDInter771",
"DDInter695"
] | Folic acid | Ethosuximide | Folic acid, also known as folate or Vitamin B9, is a member of the B vitamin family and an essential cofactor for enzymes involved in DNA and RNA synthesis. More specifically, folic acid is required by the body for the synthesis of purines, pyrimidines, and methionine before incorporation into DNA or protein. Folic aci... | An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures. | Moderate | 1 | [
[
[
356,
24,
1464
]
],
[
[
356,
6,
6365
],
[
6365,
45,
1464
]
],
[
[
356,
21,
28905
],
[
28905,
60,
1464
]
],
[
[
356,
1,
1147
],
[
1147,
... | [
[
[
"Folic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ethosuximide"
]
],
[
[
"Folic acid",
"{u} (Compound) binds {v} (Gene)",
"CYP2E1"
],
[
"CYP2E1",
"{u} (Gene) is bound by {v} (Compound)... | Folic acid (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Ethosuximide (Compound)
Folic acid (Compound) causes Irritability (Side Effect) and Irritability (Side Effect) is caused by Ethosuximide (Compound)
Folic acid (Compound) resembles Leucovorin (Compound) and Leucovorin may cause a moderate interactio... |
DB00860 | DB06723 | 891 | 115 | [
"DDInter1513",
"DDInter58"
] | Prednisolone | Aluminum hydroxide | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | Minor | 0 | [
[
[
891,
23,
115
]
],
[
[
891,
21,
28845
],
[
28845,
60,
115
]
],
[
[
891,
63,
1058
],
[
1058,
23,
115
]
],
[
[
891,
24,
1482
],
[
1482,
... | [
[
[
"Prednisolone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Aluminum hydroxide"
]
],
[
[
"Prednisolone",
"{u} (Compound) causes {v} (Side Effect)",
"Oedema"
],
[
"Oedema",
"{u} (Side Effect) is ... | Prednisolone (Compound) causes Oedema (Side Effect) and Oedema (Side Effect) is caused by Aluminum hydroxide (Compound)
Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Moexipril and Moexipril may cause a minor interaction that can limit clinical effects when taken with Alumi... |
DB10316 | DB11767 | 334 | 1,583 | [
"DDInter1248",
"DDInter1643"
] | Mumps virus strain B level jeryl lynn live antigen | Sarilumab | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approve... | Major | 2 | [
[
[
334,
25,
1583
]
],
[
[
334,
64,
850
],
[
850,
24,
1583
]
],
[
[
334,
25,
738
],
[
738,
63,
1583
]
],
[
[
334,
25,
1456
],
[
1456,
... | [
[
[
"Mumps virus strain B level jeryl lynn live antigen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sarilumab"
]
],
[
[
"Mumps virus strain B level jeryl lynn live antigen",
"{u} may lead to a major life threatening interaction when ta... | Mumps virus strain B level jeryl lynn live antigen may lead to a major life threatening interaction when taken with Brentuximab vedotin and Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Sarilumab
Mumps virus strain B level jeryl lynn live antigen may lead to a major... |
DB00388 | DB01193 | 1,636 | 819 | [
"DDInter1453",
"DDInter12"
] | Phenylephrine | Acebutolol | Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939. | A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. | Moderate | 1 | [
[
[
1636,
24,
819
]
],
[
[
1636,
24,
887
],
[
887,
1,
819
]
],
[
[
1636,
63,
726
],
[
726,
1,
819
]
],
[
[
1636,
21,
28762
],
[
28762,
... | [
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acebutolol"
]
],
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pindolol"
],
... | Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Pindolol and Pindolol (Compound) resembles Acebutolol (Compound)
Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Betaxolol and Betaxolol (Compound) resembles Acebutolol (Compound)
... |
DB08875 | DB09065 | 1,618 | 760 | [
"DDInter262",
"DDInter424"
] | Cabozantinib | Cobicistat | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Major | 2 | [
[
[
1618,
25,
760
]
],
[
[
1618,
63,
479
],
[
479,
23,
760
]
],
[
[
1618,
64,
1230
],
[
1230,
23,
760
]
],
[
[
1618,
25,
938
],
[
938,
... | [
[
[
"Cabozantinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobicistat"
]
],
[
[
"Cabozantinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
],
[
"Donepez... | Cabozantinib may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepezil may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Cabozantinib may lead to a major life threatening interaction when taken with Citalopram and Citalopram may cause ... |
DB05294 | DB11730 | 1,069 | 351 | [
"DDInter1917",
"DDInter1588"
] | Vandetanib | Ribociclib | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
1069,
25,
351
]
],
[
[
1069,
62,
1247
],
[
1247,
23,
351
]
],
[
[
1069,
63,
479
],
[
479,
23,
351
]
],
[
[
1069,
24,
861
],
[
861,
... | [
[
[
"Vandetanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Vandetanib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"Sulfam... | Vandetanib may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Vandetanib may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and... |
DB00631 | DB08916 | 372 | 26 | [
"DDInter405",
"DDInter32"
] | Clofarabine | Afatinib | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label]. For oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal grow... | Moderate | 1 | [
[
[
372,
24,
26
]
],
[
[
372,
63,
883
],
[
883,
40,
26
]
],
[
[
372,
7,
14278
],
[
14278,
45,
26
]
],
[
[
372,
6,
17404
],
[
17404,
... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Afatinib"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Afatinib (Compound)
Clofarabine (Compound) upregulates PHKG2 (Gene) and PHKG2 (Gene) is bound by Afatinib (Compound)
Clofarabine (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is boun... |
DB00112 | DB00884 | 374 | 1,008 | [
"DDInter201",
"DDInter1604"
] | Bevacizumab | Risedronic acid | There is a great deal of evidence indicating that vascular endothelial growth factor (VEGF) is important for the survival and proliferation of cancer cells.[A192939,A192837,A192891,A193275] VEGF plays an important role in angiogenesis, lymphangiogenesis, and tumor growth, which are all factors that contribute to its at... | Risedronic acid is a third generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label]. | Moderate | 1 | [
[
[
374,
24,
1008
]
],
[
[
374,
24,
1485
],
[
1485,
1,
1008
]
],
[
[
374,
25,
1151
],
[
1151,
63,
1008
]
],
[
[
374,
24,
1485
],
[
1485,
... | [
[
[
"Bevacizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risedronic acid"
]
],
[
[
"Bevacizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alendronic acid"
... | Bevacizumab may cause a moderate interaction that could exacerbate diseases when taken with Alendronic acid and Alendronic acid (Compound) resembles Risedronic acid (Compound)
Bevacizumab may lead to a major life threatening interaction when taken with Sunitinib and Sunitinib may cause a moderate interaction that could... |
DB00903 | DB09043 | 1,680 | 135 | [
"DDInter686",
"DDInter36"
] | Etacrynic acid | Albiglutide | A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as ... | Albiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on A... | Moderate | 1 | [
[
[
1680,
24,
135
]
],
[
[
1680,
63,
126
],
[
126,
23,
135
]
],
[
[
1680,
63,
870
],
[
870,
24,
135
]
],
[
[
1680,
24,
820
],
[
820,
... | [
[
[
"Etacrynic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Albiglutide"
]
],
[
[
"Etacrynic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
],
... | Etacrynic acid may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken with Albiglutide
Etacrynic acid may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone an... |
DB01246 | DB01255 | 820 | 633 | [
"DDInter45",
"DDInter1078"
] | Alimemazine | Lisdexamfetamine | A phenothiazine derivative that is used as an antipruritic. | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Moderate | 1 | [
[
[
820,
24,
633
]
],
[
[
820,
63,
551
],
[
551,
1,
633
]
],
[
[
820,
63,
80
],
[
80,
40,
633
]
],
[
[
820,
24,
1529
],
[
1529,
1,
... | [
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisdexamfetamine"
]
],
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenelzine"
],
... | Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Phenelzine and Phenelzine (Compound) resembles Lisdexamfetamine (Compound)
Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Amphetamine and Amphetamine (Compound) resembles Lisdexamfeta... |
DB00321 | DB00424 | 21 | 19 | [
"DDInter78",
"DDInter896"
] | Amitriptyline | Hyoscyamine | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | Moderate | 1 | [
[
[
21,
24,
19
]
],
[
[
21,
25,
1166
],
[
1166,
1,
19
]
],
[
[
21,
24,
85
],
[
85,
63,
19
]
],
[
[
21,
25,
290
],
[
290,
40,
1... | [
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
]
],
[
[
"Amitriptyline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dolasetron"
],
[
"Dol... | Amitriptyline may lead to a major life threatening interaction when taken with Dolasetron and Dolasetron (Compound) resembles Hyoscyamine (Compound)
Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine may cause a moderate interaction that could exacerbate ... |
DB00342 | DB00445 | 1,181 | 322 | [
"DDInter1770",
"DDInter655"
] | Terfenadine | Epirubicin | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Moderate | 1 | [
[
[
1181,
24,
322
]
],
[
[
1181,
23,
112
],
[
112,
62,
322
]
],
[
[
1181,
24,
730
],
[
730,
63,
322
]
],
[
[
1181,
23,
1387
],
[
1387,
... | [
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
]
],
[
[
"Terfenadine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[... | Terfenadine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Epirubicin
Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Deutetrabenazine ... |
DB05273 | DB12001 | 507 | 564 | [
"DDInter1638",
"DDInter7"
] | Samarium (153Sm) lexidronam | Abemaciclib | Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.Samarium ... | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Major | 2 | [
[
[
507,
25,
564
]
],
[
[
507,
64,
1213
],
[
1213,
24,
564
]
],
[
[
507,
25,
850
],
[
850,
24,
564
]
],
[
[
507,
63,
248
],
[
248,
2... | [
[
[
"Samarium (153Sm) lexidronam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Abemaciclib"
]
],
[
[
"Samarium (153Sm) lexidronam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
],
... | Samarium (153Sm) lexidronam may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Samarium (153Sm) lexidronam may lead to a major life threatening interaction when taken with Brentuximab vedoti... |
DB00414 | DB06788 | 590 | 1,616 | [
"DDInter16",
"DDInter864"
] | Acetohexamide | Histrelin | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Moderate | 1 | [
[
[
590,
24,
1616
]
],
[
[
590,
24,
1247
],
[
1247,
23,
1616
]
],
[
[
590,
24,
1664
],
[
1664,
24,
1616
]
],
[
[
590,
63,
1179
],
[
1179,
... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histrelin"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfamethoxazole"
... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Risper... |
DB00445 | DB08865 | 322 | 1,593 | [
"DDInter655",
"DDInter448"
] | Epirubicin | Crizotinib | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Major | 2 | [
[
[
322,
25,
1593
]
],
[
[
322,
18,
9202
],
[
9202,
45,
1593
]
],
[
[
322,
7,
10365
],
[
10365,
45,
1593
]
],
[
[
322,
7,
7972
],
[
7972,
... | [
[
[
"Epirubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
]
],
[
[
"Epirubicin",
"{u} (Compound) downregulates {v} (Gene)",
"PLK4"
],
[
"PLK4",
"{u} (Gene) is bound by {v} (Compound)",
"Cri... | Epirubicin (Compound) downregulates PLK4 (Gene) and PLK4 (Gene) is bound by Crizotinib (Compound)
Epirubicin (Compound) upregulates STK10 (Gene) and STK10 (Gene) is bound by Crizotinib (Compound)
Epirubicin (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Crizotinib (Compound)
Epirubicin (Comp... |
DB00401 | DB01143 | 84 | 923 | [
"DDInter1298",
"DDInter65"
] | Nisoldipine | Amifostine | Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contractio... | A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia. | Moderate | 1 | [
[
[
84,
24,
923
]
],
[
[
84,
21,
29789
],
[
29789,
60,
923
]
],
[
[
84,
1,
336
],
[
336,
24,
923
]
],
[
[
84,
24,
714
],
[
714,
24,
... | [
[
[
"Nisoldipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amifostine"
]
],
[
[
"Nisoldipine",
"{u} (Compound) causes {v} (Side Effect)",
"Supraventricular tachycardia"
],
[
"Supraventricular tachyc... | Nisoldipine (Compound) causes Supraventricular tachycardia (Side Effect) and Supraventricular tachycardia (Side Effect) is caused by Amifostine (Compound)
Nisoldipine (Compound) resembles Nifedipine (Compound) and Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Amifostine
Niso... |
DB00418 | DB01041 | 536 | 770 | [
"DDInter1650",
"DDInter1789"
] | Secobarbital | Thalidomide | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
536,
24,
770
]
],
[
[
536,
6,
7950
],
[
7950,
45,
770
]
],
[
[
536,
21,
28789
],
[
28789,
60,
770
]
],
[
[
536,
24,
849
],
[
849,
... | [
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Secobarbital",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compou... | Secobarbital (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Thalidomide (Compound)
Secobarbital (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Thalidomide (Compound)
Secobarbital may cause a moderate interaction that could exacerbate diseases whe... |
DB00618 | DB09564 | 1,572 | 1,296 | [
"DDInter498",
"DDInter930"
] | Demeclocycline | Insulin degludec | A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time. | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
1572,
24,
1296
]
],
[
[
1572,
23,
674
],
[
674,
24,
1296
]
],
[
[
1572,
62,
811
],
[
811,
24,
1296
]
],
[
[
1572,
40,
964
],
[
964,
... | [
[
[
"Demeclocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Demeclocycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Trichlormethiaz... | Demeclocycline may cause a minor interaction that can limit clinical effects when taken with Trichlormethiazide and Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Demeclocycline may cause a minor interaction that can limit clinical effects when taken ... |
DB00214 | DB00491 | 1,028 | 127 | [
"DDInter1836",
"DDInter1217"
] | Torasemide | Miglitol | Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993. | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | Moderate | 1 | [
[
[
1028,
24,
127
]
],
[
[
1028,
21,
28809
],
[
28809,
60,
127
]
],
[
[
1028,
24,
1486
],
[
1486,
63,
127
]
],
[
[
1028,
24,
245
],
[
245,... | [
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miglitol"
]
],
[
[
"Torasemide",
"{u} (Compound) causes {v} (Side Effect)",
"Diarrhoea"
],
[
"Diarrhoea",
"{u} (Side Effect) is caused... | Torasemide (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Miglitol (Compound)
Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Methylprednisolone and Methylprednisolone may cause a moderate interaction that could exacerbate diseases when take... |
DB00341 | DB01174 | 1,242 | 697 | [
"DDInter343",
"DDInter1442"
] | Cetirizine | Phenobarbital | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Moderate | 1 | [
[
[
1242,
24,
697
]
],
[
[
1242,
24,
759
],
[
759,
1,
697
]
],
[
[
1242,
63,
362
],
[
362,
1,
697
]
],
[
[
1242,
24,
536
],
[
536,
4... | [
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenobarbital"
]
],
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
],
[
... | Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone (Compound) resembles Phenobarbital (Compound)
Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Phenobarbital (Compound... |
DB00431 | DB06016 | 1,503 | 1,508 | [
"DDInter1072",
"DDInter300"
] | Lindane | Cariprazine | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary. It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT<sub>1A</sub> receptors and as an antagonist at serotonin 5-HT<sub>2A</sub> receptors. Cariprazine has been investigated in... | Moderate | 1 | [
[
[
1503,
24,
1508
]
],
[
[
1503,
24,
913
],
[
913,
63,
1508
]
],
[
[
1503,
24,
820
],
[
820,
24,
1508
]
],
[
[
1503,
63,
999
],
[
999,
... | [
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cariprazine"
]
],
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
],
[
... | Lindane may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide and Apalutamide may cause a moderate interaction that could exacerbate diseases when taken with Cariprazine
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemaz... |
DB06317 | DB09115 | 1,626 | 505 | [
"DDInter630",
"DDInter559"
] | Elotuzumab | Diiodohydroxyquinoline | Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family... | Diiodohydroxyquinoline, also known as uidoquinol and iodoquinol, is a quinoline derivative that can be used in the treatment of amoebiasis. The exact mechanism of action is unknown. Iodoquinol is not currently available in any FDA-approved products. | Moderate | 1 | [
[
[
1626,
24,
505
]
],
[
[
1626,
24,
1593
],
[
1593,
24,
505
]
],
[
[
1626,
63,
467
],
[
467,
24,
505
]
],
[
[
1626,
25,
908
],
[
908,
... | [
[
[
"Elotuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diiodohydroxyquinoline"
]
],
[
[
"Elotuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
... | Elotuzumab may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Diiodohydroxyquinoline
Elotuzumab may cause a moderate interaction that could exacerbate diseases when taken with Simvastat... |
DB00544 | DB11256 | 970 | 95 | [
"DDInter757",
"DDInter1057"
] | Fluorouracil | Levomefolic acid | A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. | Levomefolic acid (INN) is the metabolite of folic acid (Vitamin B9) and it is a predominant active form of folate found in foods and in the blood circulation, accounting for 98% of folates in human plasma . It is transported across the membranes including the blood-brain barrier into various tissues where it plays an e... | Major | 2 | [
[
[
970,
25,
95
]
],
[
[
970,
24,
663
],
[
663,
24,
95
]
],
[
[
970,
24,
60
],
[
60,
25,
95
]
],
[
[
970,
24,
663
],
[
663,
24,
... | [
[
[
"Fluorouracil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Levomefolic acid"
]
],
[
[
"Fluorouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
],
[
... | Fluorouracil may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Levomefolic acid
Fluorouracil may cause a moderate interaction that could exacerbate diseases when taken with Capecit... |
DB00549 | DB12834 | 522 | 148 | [
"DDInter1955",
"DDInter1649"
] | Zafirlukast | Secnidazole | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent. It is structurally related to other 5-nitroimidazoles, including and , but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class. Secnidazole is selective against many anaerobic Gram-positive ... | Moderate | 1 | [
[
[
522,
24,
148
]
],
[
[
522,
24,
1593
],
[
1593,
24,
148
]
],
[
[
522,
63,
597
],
[
597,
24,
148
]
],
[
[
522,
25,
1510
],
[
1510,
... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secnidazole"
]
],
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
],
[... | Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Secnidazole
Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol an... |
DB00631 | DB14509 | 372 | 1,399 | [
"DDInter405",
"DDInter1081"
] | Clofarabine | Lithium carbonate | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Moderate | 1 | [
[
[
372,
24,
1399
]
],
[
[
372,
63,
589
],
[
589,
23,
1399
]
],
[
[
372,
24,
1669
],
[
1669,
23,
1399
]
],
[
[
372,
24,
1374
],
[
1374,
... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cisplatin"
],
... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Cisplatin and Cisplatin may cause a minor interaction that can limit clinical effects when taken with Lithium carbonate
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Minocycline and ... |
DB01234 | DB06228 | 1,220 | 792 | [
"DDInter513",
"DDInter1609"
] | Dexamethasone | Rivaroxaban | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Moderate | 1 | [
[
[
1220,
24,
792
]
],
[
[
1220,
6,
4973
],
[
4973,
45,
792
]
],
[
[
1220,
7,
2384
],
[
2384,
46,
792
]
],
[
[
1220,
18,
5901
],
[
5901,
... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Dexamethasone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compou... | Dexamethasone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Rivaroxaban (Compound)
Dexamethasone (Compound) upregulates CDK6 (Gene) and CDK6 (Gene) is upregulated by Rivaroxaban (Compound)
Dexamethasone (Compound) downregulates GJA1 (Gene) and GJA1 (Gene) is downregulated by Rivaroxaban (Compound)
Dexameth... |
DB00640 | DB08881 | 1,585 | 868 | [
"DDInter31",
"DDInter1925"
] | Adenosine | Vemurafenib | The structure of adenosine was first described in 1931, though the vasodilating effects were not described in literature until the 1940s. Adenosine is indicated as an adjunct to thallium-201 in myocardial perfusion scintigraphy, though it is rarely used in this indication, having largely been replaced by [dipyridamole]... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Major | 2 | [
[
[
1585,
25,
868
]
],
[
[
1585,
18,
2852
],
[
2852,
57,
868
]
],
[
[
1585,
21,
28714
],
[
28714,
60,
868
]
],
[
[
1585,
23,
578
],
[
578,... | [
[
[
"Adenosine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
]
],
[
[
"Adenosine",
"{u} (Compound) downregulates {v} (Gene)",
"CCNB1"
],
[
"CCNB1",
"{u} (Gene) is downregulated by {v} (Compound)",
... | Adenosine (Compound) downregulates CCNB1 (Gene) and CCNB1 (Gene) is downregulated by Vemurafenib (Compound)
Adenosine (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Vemurafenib (Compound)
Adenosine may cause a minor interaction that can limit clinical effects when taken with Ticagrelor... |
DB00978 | DB01001 | 739 | 688 | [
"DDInter1084",
"DDInter1632"
] | Lomefloxacin | Salbutamol | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Moderate | 1 | [
[
[
739,
24,
688
]
],
[
[
739,
63,
455
],
[
455,
24,
688
]
],
[
[
739,
24,
1148
],
[
1148,
63,
688
]
],
[
[
739,
21,
28714
],
[
28714,
... | [
[
[
"Lomefloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
]
],
[
[
"Lomefloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
],
... | Lomefloxacin may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Lomefloxacin may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and ... |
DB00414 | DB01105 | 590 | 222 | [
"DDInter16",
"DDInter1665"
] | Acetohexamide | Sibutramine | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
590,
24,
222
]
],
[
[
590,
64,
600
],
[
600,
23,
222
]
],
[
[
590,
63,
215
],
[
215,
23,
222
]
],
[
[
590,
25,
86
],
[
86,
62,
... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Acetohexamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fluconazole"
],
[
"Fl... | Acetohexamide may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may cause a minor interaction that can limit clinical effects when taken with Sibutramine
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Indinavir and Indinavir may c... |
DB00470 | DB06077 | 530 | 879 | [
"DDInter601",
"DDInter1102"
] | Dronabinol | Lumateperone | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Moderate | 1 | [
[
[
530,
24,
879
]
],
[
[
530,
24,
214
],
[
214,
63,
879
]
],
[
[
530,
24,
392
],
[
392,
24,
879
]
],
[
[
530,
63,
999
],
[
999,
24,... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lumateperone"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
],
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Lumateperone
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and L... |
DB00681 | DB09134 | 1,287 | 1,552 | [
"DDInter85",
"DDInter966"
] | Amphotericin B | Ioversol | Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphot... | Ioversol is a non-ionic compound with a tri-iodinated benzene ring used as a contrast dye in diagnostic procedures to visualize different types of organs and tissues. Iodine has a high atomic density, which gives it the ability to attenuate X-rays. The intravascular administration of iodine compounds, such as ioversol,... | Major | 2 | [
[
[
1287,
25,
1552
]
],
[
[
1287,
25,
33
],
[
33,
24,
1552
]
],
[
[
1287,
64,
228
],
[
228,
24,
1552
]
],
[
[
1287,
24,
1605
],
[
1605,
... | [
[
[
"Amphotericin B",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ioversol"
]
],
[
[
"Amphotericin B",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amiodarone"
],
[
"Amiodarone",
... | Amphotericin B may lead to a major life threatening interaction when taken with Amiodarone and Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Ioversol
Amphotericin B may lead to a major life threatening interaction when taken with Dofetilide and Dofetilide may cause a moderat... |
DB00218 | DB08899 | 1,176 | 129 | [
"DDInter1247",
"DDInter649"
] | Moxifloxacin | Enzalutamide | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Major | 2 | [
[
[
1176,
25,
129
]
],
[
[
1176,
25,
918
],
[
918,
1,
129
]
],
[
[
1176,
21,
29377
],
[
29377,
60,
129
]
],
[
[
1176,
23,
112
],
[
112,
... | [
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
]
],
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bicalutamide"
],
[
"Bicalutamide",
... | Moxifloxacin may lead to a major life threatening interaction when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Moxifloxacin (Compound) causes Musculoskeletal pain (Side Effect) and Musculoskeletal pain (Side Effect) is caused by Enzalutamide (Compound)
Moxifloxacin may cause a ... |
DB00604 | DB00850 | 1,425 | 1,630 | [
"DDInter385",
"DDInter1432"
] | Cisapride | Perphenazine | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Major | 2 | [
[
[
1425,
25,
1630
]
],
[
[
1425,
64,
252
],
[
252,
40,
1630
]
],
[
[
1425,
25,
827
],
[
827,
40,
1630
]
],
[
[
1425,
24,
673
],
[
673,
... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Perphenazine"
]
],
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxyzine"
],
[
"Hydroxyzine",
"{u}... | Cisapride may lead to a major life threatening interaction when taken with Hydroxyzine and Hydroxyzine (Compound) resembles Perphenazine (Compound)
Cisapride may lead to a major life threatening interaction when taken with Trazodone and Trazodone (Compound) resembles Perphenazine (Compound)
Cisapride may cause a modera... |
DB00373 | DB01001 | 461 | 688 | [
"DDInter1809",
"DDInter1632"
] | Timolol | Salbutamol | Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective ag... | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Major | 2 | [
[
[
461,
25,
688
]
],
[
[
461,
25,
874
],
[
874,
24,
688
]
],
[
[
461,
1,
668
],
[
668,
64,
688
]
],
[
[
461,
24,
1636
],
[
1636,
24... | [
[
[
"Timolol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Salbutamol"
]
],
[
[
"Timolol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Epinephrine"
],
[
"Epinephrine",
"{u} may c... | Timolol may lead to a major life threatening interaction when taken with Epinephrine and Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Timolol (Compound) resembles Levobunolol (Compound) and Levobunolol may lead to a major life threatening interaction when taken ... |
DB00501 | DB08901 | 752 | 1,468 | [
"DDInter380",
"DDInter1492"
] | Cimetidine | Ponatinib | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Minor | 0 | [
[
[
752,
23,
1468
]
],
[
[
752,
24,
478
],
[
478,
24,
1468
]
],
[
[
752,
6,
10083
],
[
10083,
45,
1468
]
],
[
[
752,
18,
6351
],
[
6351,
... | [
[
[
"Cimetidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ponatinib"
]
],
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
... | Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Cimetidine (Compound) binds ABCB11 (Gene) and ABCB11 (Gene) is bound by Ponatinib (Compound)
Cimetidine (Compound) ... |
DB00649 | DB08880 | 231 | 1,510 | [
"DDInter1710",
"DDInter1771"
] | Stavudine | Teriflunomide | A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
231,
25,
1510
]
],
[
[
231,
63,
10
],
[
10,
24,
1510
]
],
[
[
231,
24,
148
],
[
148,
63,
1510
]
],
[
[
231,
1,
1477
],
[
1477,
2... | [
[
[
"Stavudine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Stavudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapsone"
],
[
"Dapsone",
... | Stavudine may cause a moderate interaction that could exacerbate diseases when taken with Dapsone and Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide
Stavudine may cause a moderate interaction that could exacerbate diseases when taken with Secnidazole and Secnidazol... |
DB00876 | DB01246 | 1,414 | 820 | [
"DDInter658",
"DDInter45"
] | Eprosartan | Alimemazine | Eprosartan is an angiotensin II receptor antagonist used to treat hypertension. It performs 2 actions on the renin angiotensin system. By preventing the binding of angiotensin II to AT1, vascular smooth muscle relaxes and vasodilation occurs. By inhibiting norepinephrine production, blood pressure is further reduced. | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
1414,
24,
820
]
],
[
[
1414,
24,
104
],
[
104,
40,
820
]
],
[
[
1414,
24,
401
],
[
401,
24,
820
]
],
[
[
1414,
21,
28662
],
[
28662,
... | [
[
[
"Eprosartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Eprosartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
[... | Eprosartan may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (Compound)
Eprosartan may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction t... |
DB00515 | DB00601 | 589 | 453 | [
"DDInter387",
"DDInter1073"
] | Cisplatin | Linezolid | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Moderate | 1 | [
[
[
589,
24,
453
]
],
[
[
589,
21,
29203
],
[
29203,
60,
453
]
],
[
[
589,
25,
770
],
[
770,
63,
453
]
],
[
[
589,
24,
713
],
[
713,
... | [
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linezolid"
]
],
[
[
"Cisplatin",
"{u} (Compound) causes {v} (Side Effect)",
"Aspartate aminotransferase increased"
],
[
"Aspartate aminotrans... | Cisplatin (Compound) causes Aspartate aminotransferase increased (Side Effect) and Aspartate aminotransferase increased (Side Effect) is caused by Linezolid (Compound)
Cisplatin may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide may cause a moderate interaction that could exace... |
DB00230 | DB00434 | 784 | 13 | [
"DDInter1516",
"DDInter459"
] | Pregabalin | Cyproheptadine | Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter. It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions. Although as per the FDA Label the mechanism of action has not been definitively characterized, there is evide... | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Moderate | 1 | [
[
[
784,
24,
13
]
],
[
[
784,
24,
104
],
[
104,
63,
13
]
],
[
[
784,
21,
28905
],
[
28905,
60,
13
]
],
[
[
784,
24,
128
],
[
128,
24... | [
[
[
"Pregabalin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
]
],
[
[
"Pregabalin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
... | Pregabalin may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine
Pregabalin (Compound) causes Irritability (Side Effect) and Irritability (Side Effect) is caused by Cypr... |
DB00279 | DB01344 | 1,152 | 1,231 | [
"DDInter1074",
"DDInter1830"
] | Liothyronine | Tolevamer | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines. It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among others, H... | Moderate | 1 | [
[
[
1152,
24,
1231
]
],
[
[
1152,
24,
660
],
[
660,
24,
1231
]
],
[
[
1152,
23,
417
],
[
417,
24,
1231
]
],
[
[
1152,
24,
1596
],
[
1596,
... | [
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolevamer"
]
],
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esomeprazole"
],
... | Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Esomeprazole and Esomeprazole may cause a moderate interaction that could exacerbate diseases when taken with Tolevamer
Liothyronine may cause a minor interaction that can limit clinical effects when taken with Sucralfate and S... |
DB00983 | DB14568 | 480 | 982 | [
"DDInter776",
"DDInter1000"
] | Formoterol | Ivosidenib | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Moderate | 1 | [
[
[
480,
24,
982
]
],
[
[
480,
24,
1032
],
[
1032,
24,
982
]
],
[
[
480,
63,
1559
],
[
1559,
24,
982
]
],
[
[
480,
63,
472
],
[
472,
... | [
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivosidenib"
]
],
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levosalbutamol"
],
... | Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Levosalbutamol and Levosalbutamol may cause a moderate interaction that could exacerbate diseases when taken with Ivosidenib
Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Famotidine an... |
DB01263 | DB09073 | 859 | 951 | [
"DDInter1494",
"DDInter1379"
] | Posaconazole | Palbociclib | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Major | 2 | [
[
[
859,
25,
951
]
],
[
[
859,
25,
1476
],
[
1476,
63,
951
]
],
[
[
859,
24,
1033
],
[
1033,
63,
951
]
],
[
[
859,
64,
467
],
[
467,
... | [
[
[
"Posaconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Palbociclib"
]
],
[
[
"Posaconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brigatinib"
],
[
"Brigatinib",
"... | Posaconazole may lead to a major life threatening interaction when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib
Posaconazole may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and Alpelisib may cau... |
DB00515 | DB01362 | 589 | 497 | [
"DDInter387",
"DDInter960"
] | Cisplatin | Iohexol | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
589,
25,
497
]
],
[
[
589,
25,
258
],
[
258,
40,
497
]
],
[
[
589,
21,
28681
],
[
28681,
60,
497
]
],
[
[
589,
24,
1680
],
[
1680,
... | [
[
[
"Cisplatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Cisplatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iodixanol"
],
[
"Iodixanol",
"{u} (Compoun... | Cisplatin may lead to a major life threatening interaction when taken with Iodixanol and Iodixanol (Compound) resembles Iohexol (Compound)
Cisplatin (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Iohexol (Compound)
Cisplatin may cause a moderate interaction that could e... |
DB00035 | DB00741 | 1,314 | 167 | [
"DDInter507",
"DDInter885"
] | Desmopressin | Hydrocortisone | Desmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body. Upon release... | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Major | 2 | [
[
[
1314,
25,
167
]
],
[
[
1314,
25,
1220
],
[
1220,
40,
167
]
],
[
[
1314,
25,
870
],
[
870,
1,
167
]
],
[
[
1314,
21,
28642
],
[
28642,
... | [
[
[
"Desmopressin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydrocortisone"
]
],
[
[
"Desmopressin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexamethasone"
],
[
"Dexamethasone"... | Desmopressin may lead to a major life threatening interaction when taken with Dexamethasone and Dexamethasone (Compound) resembles Hydrocortisone (Compound)
Desmopressin may lead to a major life threatening interaction when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Hydrocortisone (Compound)
De... |
DB00902 | DB14509 | 104 | 1,399 | [
"DDInter1168",
"DDInter1081"
] | Methdilazine | Lithium carbonate | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Moderate | 1 | [
[
[
104,
24,
1399
]
],
[
[
104,
63,
874
],
[
874,
23,
1399
]
],
[
[
104,
24,
1385
],
[
1385,
24,
1399
]
],
[
[
104,
63,
506
],
[
506,
... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a minor interaction that can limit clinical effects when taken with Lithium carbonate
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Semaglutid... |
DB00470 | DB00842 | 530 | 686 | [
"DDInter601",
"DDInter1359"
] | Dronabinol | Oxazepam | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Oxazepam is an intermediate-acting, 3-hydroxybenzodiazepine used in the treatment of alcohol withdrawal and anxiety disorders. Oxazepam, like related 3-hydroxybenzodiazepine [lorazepam], is considered less susceptible to pharmacokinetic variability based on patient-specific factors (e.g. age, liver disease) - this feat... | Moderate | 1 | [
[
[
530,
24,
686
]
],
[
[
530,
63,
695
],
[
695,
40,
686
]
],
[
[
530,
24,
1563
],
[
1563,
40,
686
]
],
[
[
530,
24,
1119
],
[
1119,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxazepam"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clozapine"
],
[
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Clozapine and Clozapine (Compound) resembles Oxazepam (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Halazepam and Halazepam (Compound) resembles Oxazepam (Compound)
Dronabin... |
DB00470 | DB00727 | 530 | 685 | [
"DDInter601",
"DDInter1304"
] | Dronabinol | Nitroglycerin | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Nitroglycerin, also known as glyceryl trinitrate, is an organic nitrate and a vasodilating agent that was first discovered in 1847. Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure ex... | Moderate | 1 | [
[
[
530,
24,
685
]
],
[
[
530,
21,
28691
],
[
28691,
60,
685
]
],
[
[
530,
24,
537
],
[
537,
62,
685
]
],
[
[
530,
24,
407
],
[
407,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nitroglycerin"
]
],
[
[
"Dronabinol",
"{u} (Compound) causes {v} (Side Effect)",
"Somnolence"
],
[
"Somnolence",
"{u} (Side Effect) is... | Dronabinol (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Nitroglycerin (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine may cause a minor interaction that can limit clinical effects when taken with Nitrog... |
DB01220 | DB08901 | 1,088 | 1,468 | [
"DDInter1593",
"DDInter1492"
] | Rifaximin | Ponatinib | Rifaximin is a semisynthetic, rifamycin-based non-systemic antibiotic, meaning that the drug will not pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics. It has multiple indications and is used in treatment of traveller's diarrhea caused by E. coli; reduc... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
1088,
24,
1468
]
],
[
[
1088,
24,
478
],
[
478,
24,
1468
]
],
[
[
1088,
6,
8374
],
[
8374,
45,
1468
]
],
[
[
1088,
21,
29271
],
[
2927... | [
[
[
"Rifaximin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Rifaximin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
... | Rifaximin may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Rifaximin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ponatinib (Compound)
Rifaximin (Compound) cau... |
DB00087 | DB00352 | 599 | 482 | [
"DDInter41",
"DDInter1814"
] | Alemtuzumab | Tioguanine | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Moderate | 1 | [
[
[
599,
24,
482
]
],
[
[
599,
24,
151
],
[
151,
63,
482
]
],
[
[
599,
24,
66
],
[
66,
24,
482
]
],
[
[
599,
63,
1184
],
[
1184,
24,... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tioguanine"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/Calif... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) and Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) may cause a moderate interaction that could exacerba... |
DB00230 | DB01233 | 784 | 1,311 | [
"DDInter1516",
"DDInter1197"
] | Pregabalin | Metoclopramide | Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter. It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions. Although as per the FDA Label the mechanism of action has not been definitively characterized, there is evide... | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Moderate | 1 | [
[
[
784,
24,
1311
]
],
[
[
784,
21,
28691
],
[
28691,
60,
1311
]
],
[
[
784,
24,
1010
],
[
1010,
23,
1311
]
],
[
[
784,
24,
649
],
[
649,
... | [
[
[
"Pregabalin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
]
],
[
[
"Pregabalin",
"{u} (Compound) causes {v} (Side Effect)",
"Somnolence"
],
[
"Somnolence",
"{u} (Side Effect) i... | Pregabalin (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Metoclopramide (Compound)
Pregabalin may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine and Mefloquine may cause a minor interaction that can limit clinical effects when taken with Met... |
DB00005 | DB00794 | 1,057 | 759 | [
"DDInter687",
"DDInter1521"
] | Etanercept | Primidone | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | Moderate | 1 | [
[
[
1057,
24,
759
]
],
[
[
1057,
24,
697
],
[
697,
40,
759
]
],
[
[
1057,
24,
362
],
[
362,
1,
759
]
],
[
[
1057,
25,
1101
],
[
1101,
... | [
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
]
],
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenobarbital"
],
[
... | Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital and Phenobarbital (Compound) resembles Primidone (Compound)
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Primidone (Compound... |
DB00738 | DB13886 | 485 | 125 | [
"DDInter1420",
"DDInter870"
] | Pentamidine | Human cytomegalovirus immune globulin | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Cytomegalovirus immunoglobulin is obtained from pooled adult human plasma selected for high titers of antibody for cytomegalovirus (CMV). It contains purified immunoglobulin G (IgG) antibodies targeting cytomegalovirus (CMV)[FDA label]. Cytomegalovirus, a member of the herpes virus family, is ubiquitous the human popul... | Major | 2 | [
[
[
485,
25,
125
]
],
[
[
485,
24,
712
],
[
712,
25,
125
]
],
[
[
485,
25,
629
],
[
629,
25,
125
]
],
[
[
485,
63,
1287
],
[
1287,
2... | [
[
[
"Pentamidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Human cytomegalovirus immune globulin"
]
],
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olsalazine"
... | Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Olsalazine and Olsalazine may lead to a major life threatening interaction when taken with Human cytomegalovirus immune globulin
Pentamidine may lead to a major life threatening interaction when taken with Sirolimus and Sirolimu... |
DB00414 | DB00831 | 590 | 1,178 | [
"DDInter16",
"DDInter1866"
] | Acetohexamide | Trifluoperazine | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Moderate | 1 | [
[
[
590,
24,
1178
]
],
[
[
590,
63,
695
],
[
695,
40,
1178
]
],
[
[
590,
24,
216
],
[
216,
40,
1178
]
],
[
[
590,
24,
1630
],
[
1630,
... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clozapine"
]... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Clozapine and Clozapine (Compound) resembles Trifluoperazine (Compound)
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Chlorpromazine and Chlorpromazine (Compound) resembles Trifl... |
DB00889 | DB01211 | 1,133 | 609 | [
"DDInter840",
"DDInter393"
] | Granisetron | Clarithromycin | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
1133,
24,
609
]
],
[
[
1133,
63,
1570
],
[
1570,
24,
609
]
],
[
[
1133,
6,
7524
],
[
7524,
45,
609
]
],
[
[
1133,
18,
10375
],
[
10375... | [
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],
... | Granisetron may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Granisetron (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Clarithromycin (Compound)
Gran... |
DB00443 | DB00678 | 251 | 240 | [
"DDInter195",
"DDInter1095"
] | Betamethasone | Losartan | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Losartan is an angiotensin II receptor blocker (ARB) used to treat hypertension. Angiotensin-converting enzyme (ACE) inhibitors are used for a similar indication but are associated with a cough. When patients with ACE inhibitor associated coughs are switched to ARBs like losartan, they have an incidence of cough simila... | Moderate | 1 | [
[
[
251,
24,
240
]
],
[
[
251,
24,
1414
],
[
1414,
1,
240
]
],
[
[
251,
63,
217
],
[
217,
1,
240
]
],
[
[
251,
24,
911
],
[
911,
40,... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Losartan"
]
],
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eprosartan"
],
... | Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Eprosartan and Eprosartan (Compound) resembles Losartan (Compound)
Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Olmesartan and Olmesartan (Compound) resembles Losartan (Compound... |
DB08938 | DB09020 | 1,384 | 28 | [
"DDInter1112",
"DDInter212"
] | Magaldrate | Bisacodyl | Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market. | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
1384,
24,
28
]
],
[
[
1384,
62,
870
],
[
870,
24,
28
]
],
[
[
1384,
63,
1250
],
[
1250,
24,
28
]
],
[
[
1384,
62,
870
],
[
870,
... | [
[
[
"Magaldrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Magaldrate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Fludrocortisone"
],
[
... | Magaldrate may cause a minor interaction that can limit clinical effects when taken with Fludrocortisone and Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Bisacodyl
Magaldrate may cause a moderate interaction that could exacerbate diseases when taken with Pazopanib and ... |
DB00612 | DB09038 | 1,121 | 1,450 | [
"DDInter216",
"DDInter636"
] | Bisoprolol | Empagliflozin | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
1121,
24,
1450
]
],
[
[
1121,
24,
659
],
[
659,
63,
1450
]
],
[
[
1121,
63,
1061
],
[
1061,
24,
1450
]
],
[
[
1121,
24,
1486
],
[
1486... | [
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
],
[... | Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and T... |
DB09481 | DB11613 | 460 | 1,519 | [
"DDInter1113",
"DDInter1924"
] | Magnesium carbonate | Velpatasvir | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Velpatasvir is a Direct-Acting Antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Moderate | 1 | [
[
[
460,
24,
1519
]
],
[
[
460,
63,
594
],
[
594,
24,
1519
]
],
[
[
460,
62,
1559
],
[
1559,
24,
1519
]
],
[
[
460,
63,
1040
],
[
1040,
... | [
[
[
"Magnesium carbonate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Velpatasvir"
]
],
[
[
"Magnesium carbonate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutini... | Magnesium carbonate may cause a moderate interaction that could exacerbate diseases when taken with Bosutinib and Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Velpatasvir
Magnesium carbonate may cause a minor interaction that can limit clinical effects when taken with Famoti... |
DB00679 | DB13074 | 684 | 877 | [
"DDInter1796",
"DDInter1110"
] | Thioridazine | Macimorelin | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Major | 2 | [
[
[
684,
25,
877
]
],
[
[
684,
23,
112
],
[
112,
23,
877
]
],
[
[
684,
63,
85
],
[
85,
24,
877
]
],
[
[
684,
25,
913
],
[
913,
24,
... | [
[
[
"Thioridazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Macimorelin"
]
],
[
[
"Thioridazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metr... | Thioridazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with Atropine and A... |
DB00850 | DB11113 | 1,630 | 657 | [
"DDInter1432",
"DDInter307"
] | Perphenazine | Castor oil | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of , which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic... | Moderate | 1 | [
[
[
1630,
24,
657
]
],
[
[
1630,
24,
927
],
[
927,
63,
657
]
],
[
[
1630,
24,
1491
],
[
1491,
24,
657
]
],
[
[
1630,
25,
985
],
[
985,
... | [
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Castor oil"
]
],
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
],
... | Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Castor oil
Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin and... |
DB00951 | DB01309 | 1,072 | 1,254 | [
"DDInter986",
"DDInter933"
] | Isoniazid | Insulin glulisine | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
1072,
24,
1254
]
],
[
[
1072,
62,
167
],
[
167,
24,
1254
]
],
[
[
1072,
63,
1645
],
[
1645,
24,
1254
]
],
[
[
1072,
23,
1220
],
[
1220... | [
[
[
"Isoniazid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Isoniazid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hydrocortisone"
],
... | Isoniazid may cause a minor interaction that can limit clinical effects when taken with Hydrocortisone and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine
Isoniazid may cause a moderate interaction that could exacerbate diseases when taken with Metformin ... |
DB01403 | DB08899 | 9 | 129 | [
"DDInter1175",
"DDInter649"
] | Methotrimeprazine | Enzalutamide | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
9,
24,
129
]
],
[
[
9,
63,
918
],
[
918,
1,
129
]
],
[
[
9,
6,
12523
],
[
12523,
45,
129
]
],
[
[
9,
62,
112
],
[
112,
23,
... | [
[
[
"Methotrimeprazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Methotrimeprazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamid... | Methotrimeprazine may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Methotrimeprazine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Enzalutamide (Compound)
Methotrimeprazine may cause a minor interact... |
DB00934 | DB06694 | 413 | 31 | [
"DDInter1124",
"DDInter1952"
] | Maprotiline | Xylometazoline (nasal) | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Xylometazoline is an alkylbenzene. | Moderate | 1 | [
[
[
413,
24,
31
]
],
[
[
413,
24,
144
],
[
144,
63,
31
]
],
[
[
413,
24,
1148
],
[
1148,
24,
31
]
],
[
[
413,
1,
1302
],
[
1302,
24,... | [
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Xylometazoline"
]
],
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
],
... | Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Xylometazoline
Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol and Olodaterol may cause a moderate interaction that could exacerbate diseases when taken with Xylometazoline
... |
DB00372 | DB01168 | 999 | 1,053 | [
"DDInter1793",
"DDInter1526"
] | Thiethylperazine | Procarbazine | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Moderate | 1 | [
[
[
999,
24,
1053
]
],
[
[
999,
24,
100
],
[
100,
24,
1053
]
],
[
[
999,
63,
1648
],
[
1648,
24,
1053
]
],
[
[
999,
24,
1603
],
[
1603,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bromphenirami... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Procarbazine
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00363 | DB00762 | 695 | 613 | [
"DDInter419",
"DDInter973"
] | Clozapine | Irinotecan | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Major | 2 | [
[
[
695,
25,
613
]
],
[
[
695,
25,
869
],
[
869,
63,
613
]
],
[
[
695,
6,
8374
],
[
8374,
45,
613
]
],
[
[
695,
18,
17366
],
[
17366,
... | [
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Irinotecan"
]
],
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Topotecan"
],
[
"Topotecan",
"{u} may c... | Clozapine may lead to a major life threatening interaction when taken with Topotecan and Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Irinotecan
Clozapine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Irinotecan (Compound)
Clozapine (Compound) downregulates C2... |
DB01156 | DB08886 | 593 | 637 | [
"DDInter252",
"DDInter126"
] | Bupropion | Asparaginase Erwinia chrysanthemi | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Asparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-aspar... | Moderate | 1 | [
[
[
593,
24,
637
]
],
[
[
593,
64,
491
],
[
491,
24,
637
]
],
[
[
593,
25,
250
],
[
250,
63,
637
]
],
[
[
593,
24,
187
],
[
187,
24,... | [
[
[
"Bupropion",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Erwinia chrysanthemi"
]
],
[
[
"Bupropion",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Peginterferon alfa-2a... | Bupropion may lead to a major life threatening interaction when taken with Peginterferon alfa-2a and Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Erwinia chrysanthemi
Bupropion may lead to a major life threatening interaction when taken with Blinatum... |
DB11988 | DB14409 | 270 | 1,129 | [
"DDInter1321",
"DDInter867"
] | Ocrelizumab | Human adenovirus e serotype 4 strain cl-68578 antigen | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
270,
24,
1129
]
],
[
[
270,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
270,
63,
1683
],
[
1683,
24,
1129
]
],
[
[
270,
24,
398
],
[
398,
... | [
[
[
"Ocrelizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Ocrelizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Ocrelizumab may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Ocrelizumab may cause a moderate interaction that could exacerbate diseases when ta... |
DB06772 | DB09054 | 310 | 384 | [
"DDInter259",
"DDInter905"
] | Cabazitaxel | Idelalisib | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
310,
24,
384
]
],
[
[
310,
24,
555
],
[
555,
23,
384
]
],
[
[
310,
62,
307
],
[
307,
23,
384
]
],
[
[
310,
63,
289
],
[
289,
24,... | [
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Netupitant"
],
[
... | Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Netupitant and Netupitant may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Cabazitaxel may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil... |
DB01267 | DB08875 | 519 | 1,618 | [
"DDInter1381",
"DDInter262"
] | Paliperidone | Cabozantinib | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
519,
25,
1618
]
],
[
[
519,
62,
112
],
[
112,
23,
1618
]
],
[
[
519,
24,
1662
],
[
1662,
63,
1618
]
],
[
[
519,
63,
480
],
[
480,
... | [
[
[
"Paliperidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Paliperidone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Met... | Paliperidone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Paliperidone may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric ... |
DB01452 | DB09241 | 993 | 1,629 | [
"DDInter532",
"DDInter1186"
] | Diamorphine | Methylene blue | Diamorphine (heroin) is a narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed) Internationally, diamorphine is ... | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Major | 2 | [
[
[
993,
25,
1629
]
],
[
[
993,
63,
1311
],
[
1311,
24,
1629
]
],
[
[
993,
62,
22
],
[
22,
25,
1629
]
],
[
[
993,
64,
593
],
[
593,
... | [
[
[
"Diamorphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylene blue"
]
],
[
[
"Diamorphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
],
[
"... | Diamorphine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Diamorphine may cause a minor interaction that can limit clinical effects when taken with Ephedrine... |
DB00063 | DB00775 | 366 | 1,226 | [
"DDInter659",
"DDInter1818"
] | Eptifibatide | Tirofiban | Synthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation. Derived from venom of the Southeastern pygmy rattlesnake (Sistrurus miliarus barbouri), eptifibatide is a cyclic heptapeptide that belongs to the class of arginin-glycin-aspartat-mimetics. | Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation. | Major | 2 | [
[
[
366,
25,
1226
]
],
[
[
366,
23,
539
],
[
539,
62,
1226
]
],
[
[
366,
24,
714
],
[
714,
63,
1226
]
],
[
[
366,
24,
940
],
[
940,
... | [
[
[
"Eptifibatide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tirofiban"
]
],
[
[
"Eptifibatide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsicum",
... | Eptifibatide may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Tirofiban
Eptifibatide may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may ... |
DB00434 | DB00572 | 13 | 85 | [
"DDInter459",
"DDInter136"
] | Cyproheptadine | Atropine | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Moderate | 1 | [
[
[
13,
24,
85
]
],
[
[
13,
63,
19
],
[
19,
24,
85
]
],
[
[
13,
6,
4304
],
[
4304,
45,
85
]
],
[
[
13,
21,
28722
],
[
28722,
60,
... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atropine"
]
],
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
... | Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Atropine
Cyproheptadine (Compound) binds CHRM2 (Gene) and CHRM2 (Gene) is bound by Atropine (Compound)
Cyproheptadine... |
DB00489 | DB01268 | 17 | 1,151 | [
"DDInter1704",
"DDInter1731"
] | Sotalol | Sunitinib | Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventric... | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Major | 2 | [
[
[
17,
25,
1151
]
],
[
[
17,
6,
3958
],
[
3958,
45,
1151
]
],
[
[
17,
21,
28653
],
[
28653,
60,
1151
]
],
[
[
17,
23,
112
],
[
112,
... | [
[
[
"Sotalol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sunitinib"
]
],
[
[
"Sotalol",
"{u} (Compound) binds {v} (Gene)",
"KCNH2"
],
[
"KCNH2",
"{u} (Gene) is bound by {v} (Compound)",
"Sunitinib"
]... | Sotalol (Compound) binds KCNH2 (Gene) and KCNH2 (Gene) is bound by Sunitinib (Compound)
Sotalol (Compound) causes Bradycardia (Side Effect) and Bradycardia (Side Effect) is caused by Sunitinib (Compound)
Sotalol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazol... |
DB00067 | DB14568 | 317 | 982 | [
"DDInter1921",
"DDInter1000"
] | Vasopressin | Ivosidenib | Vasopressin (arginine-vasopressin or antidiuretic hormone) is a nonapeptide primarily produced in the hypothalamus that exhibits diverse physiological functions related to diuresis, hemodynamic modulation, and behaviour.[A110, A111, A112, A113, A228008] Vasopressin is very similar to oxytocin, differing in the third an... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
317,
25,
982
]
],
[
[
317,
23,
112
],
[
112,
23,
982
]
],
[
[
317,
24,
543
],
[
543,
24,
982
]
],
[
[
317,
25,
11
],
[
11,
25,
... | [
[
[
"Vasopressin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Vasopressin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Vasopressin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Vasopressin may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Lo... |
DB00532 | DB11834 | 208 | 1,303 | [
"DDInter1152",
"DDInter849"
] | Mephenytoin | Guselkumab | Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subuni... | Guselkumab is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody that selectively blocks interleukin-23. IL-23 is an inflammatory cytokine that activates the CD4+ T-helper (Th17) cell pathway to mediate the inflammatory cascade that induces psoriatic plaque formation . In clinical trials, guselkumab demonstra... | Moderate | 1 | [
[
[
208,
24,
1303
]
],
[
[
208,
63,
58
],
[
58,
24,
1303
]
],
[
[
208,
24,
147
],
[
147,
24,
1303
]
],
[
[
208,
62,
608
],
[
608,
24... | [
[
[
"Mephenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Guselkumab"
]
],
[
[
"Mephenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alefacept"
],
[
... | Mephenytoin may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Guselkumab
Mephenytoin may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine and Vinbl... |
DB00341 | DB14509 | 1,242 | 1,399 | [
"DDInter343",
"DDInter1081"
] | Cetirizine | Lithium carbonate | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Moderate | 1 | [
[
[
1242,
24,
1399
]
],
[
[
1242,
24,
820
],
[
820,
24,
1399
]
],
[
[
1242,
63,
475
],
[
475,
24,
1399
]
],
[
[
1242,
62,
1031
],
[
1031,
... | [
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
],
... | Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Lithium carbonate
Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Morphine and... |
DB00865 | DB08938 | 939 | 1,384 | [
"DDInter187",
"DDInter1112"
] | Benzphetamine | Magaldrate | A sympathomimetic agent with properties similar to dextroamphetamine. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222) | Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market. | Moderate | 1 | [
[
[
939,
24,
1384
]
],
[
[
939,
24,
401
],
[
401,
23,
1384
]
],
[
[
939,
40,
1529
],
[
1529,
24,
1384
]
],
[
[
939,
63,
245
],
[
245,
... | [
[
[
"Benzphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magaldrate"
]
],
[
[
"Benzphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
... | Benzphetamine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a minor interaction that can limit clinical effects when taken with Magaldrate
Benzphetamine (Compound) resembles Metamfetamine (Compound) and Metamfetamine may cause a moderate interact... |
DB01021 | DB01088 | 674 | 714 | [
"DDInter1861",
"DDInter908"
] | Trichlormethiazide | Iloprost | A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830) | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Moderate | 1 | [
[
[
674,
24,
714
]
],
[
[
674,
63,
1648
],
[
1648,
24,
714
]
],
[
[
674,
1,
1577
],
[
1577,
24,
714
]
],
[
[
674,
24,
1450
],
[
1450,
... | [
[
[
"Trichlormethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
]
],
[
[
"Trichlormethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
... | Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Iloprost
Trichlormethiazide (Compound) resembles Hydroflumethiazide (Compound) and Hydroflumethiazide may cause a... |
DB00465 | DB00704 | 886 | 267 | [
"DDInter1010",
"DDInter1263"
] | Ketorolac | Naltrexone | Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, men... | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Moderate | 1 | [
[
[
886,
24,
267
]
],
[
[
886,
7,
3163
],
[
3163,
46,
267
]
],
[
[
886,
18,
20113
],
[
20113,
57,
267
]
],
[
[
886,
21,
28695
],
[
28695,
... | [
[
[
"Ketorolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
]
],
[
[
"Ketorolac",
"{u} (Compound) upregulates {v} (Gene)",
"TSC22D3"
],
[
"TSC22D3",
"{u} (Gene) is upregulated by {v} ... | Ketorolac (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) is upregulated by Naltrexone (Compound)
Ketorolac (Compound) downregulates IER3 (Gene) and IER3 (Gene) is downregulated by Naltrexone (Compound)
Ketorolac (Compound) causes Dyspnoea (Side Effect) and Dyspnoea (Side Effect) is caused by Naltrexone (Compo... |
DB06204 | DB08895 | 768 | 976 | [
"DDInter1746",
"DDInter1825"
] | Tapentadol | Tofacitinib | Tapentadol is a centrally-acting synthetic analgesic with a dual mechanism of action. It is a mu-opioid receptor agonist that also inhibits norepinephrine reuptake.[A260721, A36596] Tapentadol was first approved by the FDA on November 20, 2008. The extended-release formulation of tapentadol was also approved by the FDA... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Moderate | 1 | [
[
[
768,
24,
976
]
],
[
[
768,
24,
407
],
[
407,
63,
976
]
],
[
[
768,
64,
475
],
[
475,
24,
976
]
],
[
[
768,
63,
1648
],
[
1648,
2... | [
[
[
"Tapentadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib"
]
],
[
[
"Tapentadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
],
[
... | Tapentadol may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib
Tapentadol may lead to a major life threatening interaction when taken with Morphine and Morphine may cause a moderate in... |
DB00377 | DB01177 | 1,494 | 77 | [
"DDInter1382",
"DDInter904"
] | Palonosetron | Idarubicin | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Moderate | 1 | [
[
[
1494,
24,
77
]
],
[
[
1494,
6,
12523
],
[
12523,
45,
77
]
],
[
[
1494,
21,
28987
],
[
28987,
60,
77
]
],
[
[
1494,
24,
739
],
[
739,
... | [
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idarubicin"
]
],
[
[
"Palonosetron",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compoun... | Palonosetron (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Idarubicin (Compound)
Palonosetron (Compound) causes Chills (Side Effect) and Chills (Side Effect) is caused by Idarubicin (Compound)
Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin and Lo... |
DB01364 | DB01367 | 22 | 1,163 | [
"DDInter650",
"DDInter1572"
] | Ephedrine | Rasagiline | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases. | Moderate | 1 | [
[
[
22,
24,
1163
]
],
[
[
22,
21,
28714
],
[
28714,
60,
1163
]
],
[
[
22,
63,
590
],
[
590,
24,
1163
]
],
[
[
22,
40,
1445
],
[
1445,
... | [
[
[
"Ephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rasagiline"
]
],
[
[
"Ephedrine",
"{u} (Compound) causes {v} (Side Effect)",
"Asthenia"
],
[
"Asthenia",
"{u} (Side Effect) is caused b... | Ephedrine (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Rasagiline (Compound)
Ephedrine may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Rasag... |
DB09039 | DB09237 | 1,670 | 1,586 | [
"DDInter629",
"DDInter1045"
] | Eliglustat | Levamlodipine | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], an antihypertensive medication. Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. This medication was first marketed in Russia and India before being granted FDA approval. The names S-amlod... | Moderate | 1 | [
[
[
1670,
24,
1586
]
],
[
[
1670,
63,
578
],
[
578,
23,
1586
]
],
[
[
1670,
63,
478
],
[
478,
24,
1586
]
],
[
[
1670,
64,
609
],
[
609,
... | [
[
[
"Eliglustat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levamlodipine"
]
],
[
[
"Eliglustat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
],
[... | Eliglustat may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a minor interaction that can limit clinical effects when taken with Levamlodipine
Eliglustat may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Niloti... |
DB00081 | DB11988 | 273 | 270 | [
"DDInter1838",
"DDInter1321"
] | Tositumomab | Ocrelizumab | Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
273,
24,
270
]
],
[
[
273,
24,
713
],
[
713,
24,
270
]
],
[
[
273,
24,
287
],
[
287,
63,
270
]
],
[
[
273,
64,
1172
],
[
1172,
2... | [
[
[
"Tositumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Tositumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
]... | Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate and Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab
Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Diro... |
DB00424 | DB01192 | 19 | 560 | [
"DDInter896",
"DDInter1372"
] | Hyoscyamine | Oxymorphone | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092). O... | Moderate | 1 | [
[
[
19,
24,
560
]
],
[
[
19,
24,
828
],
[
828,
1,
560
]
],
[
[
19,
63,
421
],
[
421,
1,
560
]
],
[
[
19,
21,
28695
],
[
28695,
60,
... | [
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxymorphone"
]
],
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxycodone"
],
[
... | Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone and Oxycodone (Compound) resembles Oxymorphone (Compound)
Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Hydromorphone and Hydromorphone (Compound) resembles Oxymorphone (Co... |
DB00660 | DB01233 | 1,470 | 1,311 | [
"DDInter1163",
"DDInter1197"
] | Metaxalone | Metoclopramide | Metaxalone is a moderate to strong muscle relaxant used in the symptomatic treatment of musculoskeletal pain caused by strains, sprains, and other musculoskeletal conditions. It is marketed by King Pharmaceuticals under the brand name Skelaxin®. Its main mechanism of action is thought to involve general central nervous... | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Moderate | 1 | [
[
[
1470,
24,
1311
]
],
[
[
1470,
21,
28691
],
[
28691,
60,
1311
]
],
[
[
1470,
24,
649
],
[
649,
63,
1311
]
],
[
[
1470,
24,
662
],
[
662... | [
[
[
"Metaxalone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
]
],
[
[
"Metaxalone",
"{u} (Compound) causes {v} (Side Effect)",
"Somnolence"
],
[
"Somnolence",
"{u} (Side Effect) i... | Metaxalone (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Metoclopramide (Compound)
Metaxalone may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with M... |
DB00261 | DB01267 | 702 | 519 | [
"DDInter93",
"DDInter1381"
] | Anagrelide | Paliperidone | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Major | 2 | [
[
[
702,
25,
519
]
],
[
[
702,
25,
1664
],
[
1664,
1,
519
]
],
[
[
702,
21,
29459
],
[
29459,
60,
519
]
],
[
[
702,
23,
112
],
[
112,
... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Paliperidone"
]
],
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Risperidone"
],
[
"Risperidone",
"{... | Anagrelide may lead to a major life threatening interaction when taken with Risperidone and Risperidone (Compound) resembles Paliperidone (Compound)
Anagrelide (Compound) causes Skin discolouration (Side Effect) and Skin discolouration (Side Effect) is caused by Paliperidone (Compound)
Anagrelide may cause a minor inte... |
DB00983 | DB08868 | 480 | 1,011 | [
"DDInter776",
"DDInter737"
] | Formoterol | Fingolimod | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Moderate | 1 | [
[
[
480,
24,
1011
]
],
[
[
480,
6,
12523
],
[
12523,
45,
1011
]
],
[
[
480,
21,
28859
],
[
28859,
60,
1011
]
],
[
[
480,
24,
144
],
[
144,... | [
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fingolimod"
]
],
[
[
"Formoterol",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",... | Formoterol (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Fingolimod (Compound)
Formoterol (Compound) causes Atrioventricular block (Side Effect) and Atrioventricular block (Side Effect) is caused by Fingolimod (Compound)
Formoterol may cause a moderate interaction that could exacerbate diseases when take... |
DB00261 | DB00889 | 702 | 1,133 | [
"DDInter93",
"DDInter840"
] | Anagrelide | Granisetron | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Major | 2 | [
[
[
702,
25,
1133
]
],
[
[
702,
18,
4729
],
[
4729,
57,
1133
]
],
[
[
702,
21,
28851
],
[
28851,
60,
1133
]
],
[
[
702,
23,
112
],
[
112,
... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Granisetron"
]
],
[
[
"Anagrelide",
"{u} (Compound) downregulates {v} (Gene)",
"EBNA1BP2"
],
[
"EBNA1BP2",
"{u} (Gene) is downregulated by {v} (Compo... | Anagrelide (Compound) downregulates EBNA1BP2 (Gene) and EBNA1BP2 (Gene) is downregulated by Granisetron (Compound)
Anagrelide (Compound) causes Hepatic enzyme increased (Side Effect) and Hepatic enzyme increased (Side Effect) is caused by Granisetron (Compound)
Anagrelide may cause a minor interaction that can limit cl... |
DB00384 | DB01249 | 1,275 | 258 | [
"DDInter1859",
"DDInter958"
] | Triamterene | Iodixanol | Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side. Since it a... | Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents. | Moderate | 1 | [
[
[
1275,
24,
258
]
],
[
[
1275,
24,
497
],
[
497,
1,
258
]
],
[
[
1275,
21,
28722
],
[
28722,
60,
258
]
],
[
[
1275,
63,
1648
],
[
1648,
... | [
[
[
"Triamterene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodixanol"
]
],
[
[
"Triamterene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iohexol"
],
[
... | Triamterene may cause a moderate interaction that could exacerbate diseases when taken with Iohexol and Iohexol (Compound) resembles Iodixanol (Compound)
Triamterene (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Iodixanol (Compound)
Triamterene may cause a moderate interaction that could ... |
DB01045 | DB09039 | 463 | 1,670 | [
"DDInter1590",
"DDInter629"
] | Rifampicin | Eliglustat | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Major | 2 | [
[
[
463,
25,
1670
]
],
[
[
463,
25,
1135
],
[
1135,
62,
1670
]
],
[
[
463,
25,
1409
],
[
1409,
24,
1670
]
],
[
[
463,
63,
322
],
[
322,
... | [
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eliglustat"
]
],
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} may... | Rifampicin may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Eliglustat
Rifampicin may lead to a major life threatening interaction when taken with Apixaban and Apixaban may cause a moderate interaction ... |
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