drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00222 | DB00575 | 245 | 1,020 | [
"DDInter825",
"DDInter412"
] | Glimepiride | Clonidine | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors. This activity is useful for the treatment of hypertension, severe pain, and ADHD.[L7237,L7240,L7243,L7246] Clonidine was granted FDA approval on 3 September 1974. | Moderate | 1 | [
[
[
245,
24,
1020
]
],
[
[
245,
24,
1512
],
[
1512,
40,
1020
]
],
[
[
245,
21,
28810
],
[
28810,
60,
1020
]
],
[
[
245,
24,
433
],
[
433,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clonidine"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenac"
],
[
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac (Compound) resembles Clonidine (Compound)
Glimepiride (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Clonidine (Compound)
Glimepiride may caus... |
DB01191 | DB01192 | 1,039 | 560 | [
"DDInter518",
"DDInter1372"
] | Dexfenfluramine | Oxymorphone | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092). O... | Moderate | 1 | [
[
[
1039,
24,
560
]
],
[
[
1039,
63,
828
],
[
828,
1,
560
]
],
[
[
1039,
6,
12523
],
[
12523,
45,
560
]
],
[
[
1039,
64,
506
],
[
506,
... | [
[
[
"Dexfenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxymorphone"
]
],
[
[
"Dexfenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxycodone"
]... | Dexfenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone and Oxycodone (Compound) resembles Oxymorphone (Compound)
Dexfenfluramine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Oxymorphone (Compound)
Dexfenfluramine may lead to a major life threatening int... |
DB00572 | DB00719 | 85 | 1,219 | [
"DDInter136",
"DDInter149"
] | Atropine | Azatadine | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Moderate | 1 | [
[
[
85,
24,
1219
]
],
[
[
85,
63,
13
],
[
13,
24,
1219
]
],
[
[
85,
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830
],
[
830,
1,
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]
],
[
[
85,
24,
1170
],
[
1170,
63,
... | [
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azatadine"
]
],
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
[
... | Atropine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Atropine may cause a moderate interaction that could exacerbate diseases when taken with Phenindamine and P... |
DB08820 | DB11560 | 1,478 | 1,678 | [
"DDInter997",
"DDInter1038"
] | Ivacaftor | Lesinurad | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Lesinurad is an oral uric acid transporter 1 (URAT1) inhibitor indicated for the treatment of hyperuricemia associated with gout. It reduces serum uric acid concentration through the inhibition of URAT1, an enzyme responsible for reuptake of uric acid from the renal tubule, and OAT4, another uric acid transporter assoc... | Moderate | 1 | [
[
[
1478,
24,
1678
]
],
[
[
1478,
63,
1374
],
[
1374,
24,
1678
]
],
[
[
1478,
25,
913
],
[
913,
63,
1678
]
],
[
[
1478,
24,
1040
],
[
1040... | [
[
[
"Ivacaftor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lesinurad"
]
],
[
[
"Ivacaftor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
],
[
... | Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone may cause a moderate interaction that could exacerbate diseases when taken with Lesinurad
Ivacaftor may lead to a major life threatening interaction when taken with Apalutamide and Apalutamide may cause... |
DB09075 | DB14357 | 498 | 944 | [
"DDInter621",
"DDInter347"
] | Edoxaban | Chamomile | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Chamomile is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. | Minor | 0 | [
[
[
498,
23,
944
]
],
[
[
498,
64,
256
],
[
256,
23,
944
]
],
[
[
498,
25,
1421
],
[
1421,
23,
944
]
],
[
[
498,
64,
256
],
[
256,
6... | [
[
[
"Edoxaban",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
]
],
[
[
"Edoxaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prasugrel"
],
[
"Prasugrel",
... | Edoxaban may lead to a major life threatening interaction when taken with Prasugrel and Prasugrel may cause a minor interaction that can limit clinical effects when taken with Chamomile
Edoxaban may lead to a major life threatening interaction when taken with Betrixaban and Betrixaban may cause a minor interaction that... |
DB00745 | DB00816 | 307 | 1,674 | [
"DDInter1236",
"DDInter1346"
] | Modafinil | Orciprenaline | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Moderate | 1 | [
[
[
307,
24,
1674
]
],
[
[
307,
21,
28921
],
[
28921,
60,
1674
]
],
[
[
307,
62,
251
],
[
251,
23,
1674
]
],
[
[
307,
23,
891
],
[
891,
... | [
[
[
"Modafinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orciprenaline"
]
],
[
[
"Modafinil",
"{u} (Compound) causes {v} (Side Effect)",
"Dizziness"
],
[
"Dizziness",
"{u} (Side Effect) is cau... | Modafinil (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Orciprenaline (Compound)
Modafinil may cause a minor interaction that can limit clinical effects when taken with Betamethasone and Betamethasone may cause a minor interaction that can limit clinical effects when taken with Orci... |
DB06674 | DB15965 | 908 | 1,330 | [
"DDInter837",
"DDInter1270"
] | Golimumab | Naxitamab | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Naxitamab (humanized 3F8, hu3F8) is an IgG1 monoclonal antibody directed against the oncofetal differentiation antigen GD2 disialoganglioside.[L24454,A224604] Normally expressed during fetal development and in mature neurons, pain fibers, and skin cells, GD2 constitutes a highly efficient target in the treatment of neu... | Major | 2 | [
[
[
908,
25,
1330
]
],
[
[
908,
23,
1193
],
[
1193,
23,
1330
]
],
[
[
908,
64,
1532
],
[
1532,
24,
1330
]
],
[
[
908,
63,
14
],
[
14,
... | [
[
[
"Golimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naxitamab"
]
],
[
[
"Golimumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Zinc glucon... | Golimumab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Naxitamab
Golimumab may lead to a major life threatening interaction when taken with Ifosfamide and Ifosfamide may cause... |
DB00352 | DB06317 | 482 | 1,626 | [
"DDInter1814",
"DDInter630"
] | Tioguanine | Elotuzumab | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family... | Moderate | 1 | [
[
[
482,
24,
1626
]
],
[
[
482,
63,
1463
],
[
1463,
24,
1626
]
],
[
[
482,
24,
597
],
[
597,
24,
1626
]
],
[
[
482,
24,
200
],
[
200,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elotuzumab"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lovastatin"
],
[
... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Lovastatin and Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Elotuzumab
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and C... |
DB00582 | DB01064 | 1,622 | 1,148 | [
"DDInter1946",
"DDInter987"
] | Voriconazole | Isoprenaline | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Moderate | 1 | [
[
[
1622,
24,
1148
]
],
[
[
1622,
24,
480
],
[
480,
24,
1148
]
],
[
[
1622,
21,
28717
],
[
28717,
60,
1148
]
],
[
[
1622,
24,
423
],
[
423... | [
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
]
],
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
... | Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Voriconazole (Compound) causes Flushing (Side Effect) and Flushing (Side Effect) is caused by Isoprenaline (... |
DB06822 | DB08918 | 802 | 41 | [
"DDInter1812",
"DDInter1059"
] | Tinzaparin | Levomilnacipran | Tinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for h... | Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake.[A261181, A38560] Levomilnacipran is the more active 1S,2R-enantiomer in the racemate [milnacipran].[A261181, L47956] Once administered, interc... | Moderate | 1 | [
[
[
802,
24,
41
]
],
[
[
802,
63,
901
],
[
901,
40,
41
]
],
[
[
802,
25,
498
],
[
498,
63,
41
]
],
[
[
802,
64,
330
],
[
330,
24,
... | [
[
[
"Tinzaparin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
]
],
[
[
"Tinzaparin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milnacipran"
],
... | Tinzaparin may cause a moderate interaction that could exacerbate diseases when taken with Milnacipran and Milnacipran (Compound) resembles Levomilnacipran (Compound)
Tinzaparin may lead to a major life threatening interaction when taken with Edoxaban and Edoxaban may cause a moderate interaction that could exacerbate ... |
DB00497 | DB06372 | 828 | 259 | [
"DDInter1366",
"DDInter1594"
] | Oxycodone | Rilonacept | Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.[Label] The f... | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
828,
24,
259
]
],
[
[
828,
24,
1619
],
[
1619,
63,
259
]
],
[
[
828,
24,
478
],
[
478,
24,
259
]
],
[
[
828,
25,
351
],
[
351,
6... | [
[
[
"Oxycodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Oxycodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
],
[
... | Oxycodone may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept
Oxycodone may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib m... |
DB00182 | DB00619 | 80 | 1,419 | [
"DDInter84",
"DDInter909"
] | Amphetamine | Imatinib | Amphetamine, a compound discovered over 100 years ago, is one of the more restricted controlled drugs. It was previously used for a large variety of conditions and this changed until this point where its use is highly restricted. Amphetamine, with the chemical formula alpha-methylphenethylamine, was discovered in 1910 ... | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Moderate | 1 | [
[
[
80,
24,
1419
]
],
[
[
80,
6,
12523
],
[
12523,
45,
1419
]
],
[
[
80,
21,
28762
],
[
28762,
60,
1419
]
],
[
[
80,
25,
222
],
[
222,
... | [
[
[
"Amphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
]
],
[
[
"Amphetamine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",... | Amphetamine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Imatinib (Compound)
Amphetamine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Imatinib (Compound)
Amphetamine may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may cause... |
DB05239 | DB09039 | 866 | 1,670 | [
"DDInter425",
"DDInter629"
] | Cobimetinib | Eliglustat | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Moderate | 1 | [
[
[
866,
24,
1670
]
],
[
[
866,
63,
839
],
[
839,
24,
1670
]
],
[
[
866,
24,
943
],
[
943,
63,
1670
]
],
[
[
866,
64,
1220
],
[
1220,
... | [
[
[
"Cobimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eliglustat"
]
],
[
[
"Cobimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Grepafloxacin"
],
... | Cobimetinib may cause a moderate interaction that could exacerbate diseases when taken with Grepafloxacin and Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Eliglustat
Cobimetinib may cause a moderate interaction that could exacerbate diseases when taken with Sarecycline a... |
DB00467 | DB00741 | 1,467 | 167 | [
"DDInter644",
"DDInter885"
] | Enoxacin | Hydrocortisone | A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Major | 2 | [
[
[
1467,
25,
167
]
],
[
[
1467,
25,
1220
],
[
1220,
40,
167
]
],
[
[
1467,
25,
870
],
[
870,
1,
167
]
],
[
[
1467,
64,
251
],
[
251,
... | [
[
[
"Enoxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydrocortisone"
]
],
[
[
"Enoxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexamethasone"
],
[
"Dexamethasone",
... | Enoxacin may lead to a major life threatening interaction when taken with Dexamethasone and Dexamethasone (Compound) resembles Hydrocortisone (Compound)
Enoxacin may lead to a major life threatening interaction when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Hydrocortisone (Compound)
Enoxacin m... |
DB00584 | DB09122 | 610 | 1,613 | [
"DDInter638",
"DDInter1409"
] | Enalapril | Peginterferon beta-1a | Enalapril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor drug class that works on the renin-angiotensin-aldosterone system, which is responsible for the regulation of blood pressure and fluid and electrolyte homeostasis. Enalapril is an orally-active and long-acting nonsulphydryl antihypert... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
610,
24,
1613
]
],
[
[
610,
24,
1274
],
[
1274,
24,
1613
]
],
[
[
610,
24,
1383
],
[
1383,
63,
1613
]
],
[
[
610,
1,
1603
],
[
1603,
... | [
[
[
"Enalapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Enalapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
... | Enalapril may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Enalapril may cause a moderate interaction that could exacerbate diseases when taken with Sodium s... |
DB00581 | DB06603 | 355 | 39 | [
"DDInter1018",
"DDInter1387"
] | Lactulose | Panobinostat | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Moderate | 1 | [
[
[
355,
24,
39
]
],
[
[
355,
24,
688
],
[
688,
24,
39
]
],
[
[
355,
24,
720
],
[
720,
63,
39
]
],
[
[
355,
23,
286
],
[
286,
63,
... | [
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Panobinostat"
]
],
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
],
[
... | Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Panobinostat
Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil and Miner... |
DB09570 | DB11793 | 1,480 | 738 | [
"DDInter1002",
"DDInter1297"
] | Ixazomib | Niraparib | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
1480,
24,
738
]
],
[
[
1480,
63,
663
],
[
663,
24,
738
]
],
[
[
1480,
24,
496
],
[
496,
24,
738
]
],
[
[
1480,
64,
759
],
[
759,
... | [
[
[
"Ixazomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Ixazomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
],
[
... | Ixazomib may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Ixazomib may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine an... |
DB01255 | DB09481 | 633 | 460 | [
"DDInter1078",
"DDInter1113"
] | Lisdexamfetamine | Magnesium carbonate | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Moderate | 1 | [
[
[
633,
24,
460
]
],
[
[
633,
63,
401
],
[
401,
23,
460
]
],
[
[
633,
1,
1523
],
[
1523,
23,
460
]
],
[
[
633,
40,
743
],
[
743,
23... | [
[
[
"Lisdexamfetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Lisdexamfetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promet... | Lisdexamfetamine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Lisdexamfetamine (Compound) resembles Labetalol (Compound) and Labetalol may cause a minor inte... |
DB00197 | DB00367 | 1,324 | 566 | [
"DDInter1881",
"DDInter1061"
] | Troglitazone | Levonorgestrel | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of ... | Moderate | 1 | [
[
[
1324,
24,
566
]
],
[
[
1324,
24,
1336
],
[
1336,
40,
566
]
],
[
[
1324,
24,
1657
],
[
1657,
1,
566
]
],
[
[
1324,
24,
1130
],
[
1130,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levonorgestrel"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etonogestrel"
]... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Etonogestrel and Etonogestrel (Compound) resembles Levonorgestrel (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Desogestrel and Desogestrel (Compound) resembles Levonorg... |
DB00393 | DB09340 | 854 | 1,013 | [
"DDInter1295",
"DDInter1895"
] | Nimodipine | Tyropanoic acid | Nimodipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth muscle contraction ... | Tyropanoic acid is a radiocontrast agent used in cholecystography, the X-ray diagnosis of gallstones under the trade names include Bilopaque, Lumopaque, Tyropaque, and Bilopac. The molecule contains three heavy iodine atoms which obstruct X-rays in the same way as the calcium in bones, which results in a visible image ... | Moderate | 1 | [
[
[
854,
24,
1013
]
],
[
[
854,
1,
1081
],
[
1081,
24,
1013
]
],
[
[
854,
24,
1431
],
[
1431,
24,
1013
]
],
[
[
854,
1,
1081
],
[
1081,
... | [
[
[
"Nimodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tyropanoic acid"
]
],
[
[
"Nimodipine",
"{u} (Compound) resembles {v} (Compound)",
"Nicardipine"
],
[
"Nicardipine",
"{u} may cause a ... | Nimodipine (Compound) resembles Nicardipine (Compound) and Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Tyropanoic acid
Nimodipine may cause a moderate interaction that could exacerbate diseases when taken with Gadopentetic acid and Gadopentetic acid may cause a moderate i... |
DB00460 | DB00692 | 612 | 274 | [
"DDInter1929",
"DDInter1448"
] | Verteporfin | Phentolamine | Verteporfin, marketed as Visudyne, is a benzoporphyrin derivative. It is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 693 n... | Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[... | Moderate | 1 | [
[
[
612,
24,
274
]
],
[
[
612,
21,
28763
],
[
28763,
60,
274
]
],
[
[
612,
24,
104
],
[
104,
63,
274
]
],
[
[
612,
63,
1061
],
[
1061,
... | [
[
[
"Verteporfin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phentolamine"
]
],
[
[
"Verteporfin",
"{u} (Compound) causes {v} (Side Effect)",
"Chest pain"
],
[
"Chest pain",
"{u} (Side Effect) i... | Verteporfin (Compound) causes Chest pain (Side Effect) and Chest pain (Side Effect) is caused by Phentolamine (Compound)
Verteporfin may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB01072 | DB09082 | 915 | 659 | [
"DDInter129",
"DDInter1934"
] | Atazanavir | Vilanterol | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
915,
24,
659
]
],
[
[
915,
24,
1220
],
[
1220,
23,
659
]
],
[
[
915,
63,
891
],
[
891,
23,
659
]
],
[
[
915,
64,
175
],
[
175,
2... | [
[
[
"Atazanavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Atazanavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
[... | Atazanavir may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Atazanavir may cause a moderate interaction that could exacerbate diseases when taken with Prednisolone and ... |
DB00106 | DB00640 | 618 | 1,585 | [
"DDInter4",
"DDInter31"
] | Abarelix | Adenosine | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | The structure of adenosine was first described in 1931, though the vasodilating effects were not described in literature until the 1940s. Adenosine is indicated as an adjunct to thallium-201 in myocardial perfusion scintigraphy, though it is rarely used in this indication, having largely been replaced by [dipyridamole]... | Moderate | 1 | [
[
[
618,
24,
1585
]
],
[
[
618,
24,
477
],
[
477,
63,
1585
]
],
[
[
618,
24,
79
],
[
79,
24,
1585
]
],
[
[
618,
25,
877
],
[
877,
63... | [
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Adenosine"
]
],
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
],
[
"... | Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Cilostazol and Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Adenosine
Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib ma... |
DB01173 | DB01246 | 358 | 820 | [
"DDInter1349",
"DDInter45"
] | Orphenadrine | Alimemazine | A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm. | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
358,
24,
820
]
],
[
[
358,
63,
104
],
[
104,
40,
820
]
],
[
[
358,
74,
401
],
[
401,
24,
820
]
],
[
[
358,
40,
11244
],
[
11244,
... | [
[
[
"Orphenadrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Orphenadrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
... | Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (Compound)
Orphenadrine (Compound) resembles Promethazine (Compound) and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00938 | DB06292 | 455 | 549 | [
"DDInter1635",
"DDInter474"
] | Salmeterol | Dapagliflozin | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
455,
24,
549
]
],
[
[
455,
24,
1344
],
[
1344,
40,
549
]
],
[
[
455,
6,
8374
],
[
8374,
45,
549
]
],
[
[
455,
21,
28882
],
[
28882,
... | [
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
... | Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Salmeterol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dapagliflozin (Compound)
Salmeterol (Compound) causes Body temperature increase... |
DB11978 | DB15093 | 124 | 1,654 | [
"DDInter822",
"DDInter1698"
] | Glasdegib | Somapacitan | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
124,
24,
1654
]
],
[
[
124,
62,
1135
],
[
1135,
24,
1654
]
],
[
[
124,
64,
351
],
[
351,
24,
1654
]
],
[
[
124,
63,
1010
],
[
1010,
... | [
[
[
"Glasdegib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Glasdegib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Glasdegib may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a moderate interaction that could exacerbate diseases when taken with Somapacitan
Glasdegib may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause a mod... |
DB00564 | DB04837 | 1,236 | 649 | [
"DDInter293",
"DDInter407"
] | Carbamazepine | Clofedanol | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
1236,
24,
649
]
],
[
[
1236,
24,
1376
],
[
1376,
24,
649
]
],
[
[
1236,
1,
1405
],
[
1405,
24,
649
]
],
[
[
1236,
1,
293
],
[
293,
... | [
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
... | Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Carbamazepine (Compound) resembles Cyclobenzaprine (Compound) and Cyclobenzaprine may cause a moder... |
DB09115 | DB09420 | 505 | 1,074 | [
"DDInter559",
"DDInter953"
] | Diiodohydroxyquinoline | Iodide I-123 | Diiodohydroxyquinoline, also known as uidoquinol and iodoquinol, is a quinoline derivative that can be used in the treatment of amoebiasis. The exact mechanism of action is unknown. Iodoquinol is not currently available in any FDA-approved products. | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Moderate | 1 | [
[
[
505,
24,
1074
]
],
[
[
505,
63,
10
],
[
10,
24,
1074
]
],
[
[
505,
24,
148
],
[
148,
63,
1074
]
],
[
[
505,
63,
10
],
[
10,
35,
... | [
[
[
"Diiodohydroxyquinoline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
]
],
[
[
"Diiodohydroxyquinoline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"D... | Diiodohydroxyquinoline may cause a moderate interaction that could exacerbate diseases when taken with Dapsone and Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123
Diiodohydroxyquinoline may cause a moderate interaction that could exacerbate diseases when taken with S... |
DB08932 | DB11979 | 1,398 | 1,320 | [
"DDInter1111",
"DDInter625"
] | Macitentan | Elagolix | Macitentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension. It was first approved by the FDA in 2013. Macitentan differs from its predecessor [bosentan] due to its lower risk of hepatotoxicity. | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
1398,
24,
1320
]
],
[
[
1398,
64,
129
],
[
129,
24,
1320
]
],
[
[
1398,
63,
372
],
[
372,
24,
1320
]
],
[
[
1398,
25,
913
],
[
913,
... | [
[
[
"Macitentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Macitentan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
],
[
"Enzalutami... | Macitentan may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Elagolix
Macitentan may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine may ca... |
DB08868 | DB14509 | 1,011 | 1,399 | [
"DDInter737",
"DDInter1081"
] | Fingolimod | Lithium carbonate | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Major | 2 | [
[
[
1011,
25,
1399
]
],
[
[
1011,
64,
589
],
[
589,
23,
1399
]
],
[
[
1011,
64,
1374
],
[
1374,
24,
1399
]
],
[
[
1011,
63,
1674
],
[
1674... | [
[
[
"Fingolimod",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Fingolimod",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cisplatin"
],
[
"Cisplatin",
"... | Fingolimod may lead to a major life threatening interaction when taken with Cisplatin and Cisplatin may cause a minor interaction that can limit clinical effects when taken with Lithium carbonate
Fingolimod may lead to a major life threatening interaction when taken with Abiraterone and Abiraterone may cause a moderate... |
DB08903 | DB09065 | 996 | 760 | [
"DDInter170",
"DDInter424"
] | Bedaquiline | Cobicistat | Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affe... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
996,
24,
760
]
],
[
[
996,
63,
1101
],
[
1101,
23,
760
]
],
[
[
996,
64,
1374
],
[
1374,
23,
760
]
],
[
[
996,
63,
1195
],
[
1195,
... | [
[
[
"Bedaquiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Bedaquiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Bedaquiline may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Bedaquiline may lead to a major life threatening interaction when taken with Abiraterone and Abiraterone may caus... |
DB08875 | DB15093 | 1,618 | 1,654 | [
"DDInter262",
"DDInter1698"
] | Cabozantinib | Somapacitan | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
1618,
24,
1654
]
],
[
[
1618,
23,
1135
],
[
1135,
24,
1654
]
],
[
[
1618,
25,
351
],
[
351,
24,
1654
]
],
[
[
1618,
64,
1512
],
[
1512... | [
[
[
"Cabozantinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Cabozantinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Cabozantinib may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a moderate interaction that could exacerbate diseases when taken with Somapacitan
Cabozantinib may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause... |
DB00880 | DB01143 | 359 | 923 | [
"DDInter360",
"DDInter65"
] | Chlorothiazide | Amifostine | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) | A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia. | Moderate | 1 | [
[
[
359,
24,
923
]
],
[
[
359,
21,
28864
],
[
28864,
60,
923
]
],
[
[
359,
40,
811
],
[
811,
24,
923
]
],
[
[
359,
40,
178
],
[
178,
... | [
[
[
"Chlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amifostine"
]
],
[
[
"Chlorothiazide",
"{u} (Compound) causes {v} (Side Effect)",
"Erythema multiforme"
],
[
"Erythema multiforme",
... | Chlorothiazide (Compound) causes Erythema multiforme (Side Effect) and Erythema multiforme (Side Effect) is caused by Amifostine (Compound)
Chlorothiazide (Compound) resembles Metolazone (Compound) and Metolazone may cause a moderate interaction that could exacerbate diseases when taken with Amifostine
Chlorothiazide (... |
DB00857 | DB06702 | 1,387 | 573 | [
"DDInter1768",
"DDInter731"
] | Terbinafine | Fesoterodine | Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epox... | Fesoterodine is an antimuscarinic prodrug for the treatment of overactive bladder syndrome. | Moderate | 1 | [
[
[
1387,
24,
573
]
],
[
[
1387,
23,
211
],
[
211,
1,
573
]
],
[
[
1387,
6,
12523
],
[
12523,
45,
573
]
],
[
[
1387,
21,
28681
],
[
28681,... | [
[
[
"Terbinafine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fesoterodine"
]
],
[
[
"Terbinafine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Tolterodine"
],
[... | Terbinafine may cause a minor interaction that can limit clinical effects when taken with Tolterodine and Tolterodine (Compound) resembles Fesoterodine (Compound)
Terbinafine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Fesoterodine (Compound)
Terbinafine (Compound) causes Hypersensitivity (Side Effect)... |
DB00030 | DB00717 | 1,685 | 1,197 | [
"DDInter934",
"DDInter1312"
] | Insulin human | Norethisterone | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins. It is further classified as a second-generation progestin, along with [levonorgestrel] and its derivatives, and is the active form of several other progestins including [no... | Moderate | 1 | [
[
[
1685,
24,
1197
]
],
[
[
1685,
24,
155
],
[
155,
1,
1197
]
],
[
[
1685,
24,
984
],
[
984,
40,
1197
]
],
[
[
1685,
24,
1130
],
[
1130,
... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norethisterone"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxymesterone"
... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Fluoxymesterone and Fluoxymesterone (Compound) resembles Norethisterone (Compound)
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Danazol and Danazol (Compound) resembles Norethis... |
DB01278 | DB09564 | 1,021 | 1,296 | [
"DDInter1506",
"DDInter930"
] | Pramlintide | Insulin degludec | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
1021,
24,
1296
]
],
[
[
1021,
62,
1103
],
[
1103,
23,
1296
]
],
[
[
1021,
63,
1411
],
[
1411,
24,
1296
]
],
[
[
1021,
24,
1379
],
[
13... | [
[
[
"Pramlintide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Pramlintide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
],
... | Pramlintide may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Insulin degludec
Pramlintide may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and T... |
DB00295 | DB00496 | 475 | 194 | [
"DDInter1244",
"DDInter480"
] | Morphine | Darifenacin | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence. Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it should not be used in people with urinary retention. It is unknown if M3 receptor ... | Moderate | 1 | [
[
[
475,
24,
194
]
],
[
[
475,
25,
704
],
[
704,
1,
194
]
],
[
[
475,
24,
1511
],
[
1511,
63,
194
]
],
[
[
475,
6,
8374
],
[
8374,
4... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darifenacin"
]
],
[
[
"Morphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fentanyl"
],
[
"Fentanyl",
... | Morphine may lead to a major life threatening interaction when taken with Fentanyl and Fentanyl (Compound) resembles Darifenacin (Compound)
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases... |
DB00572 | DB01019 | 85 | 427 | [
"DDInter136",
"DDInter199"
] | Atropine | Bethanechol | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Bethanechol is a synthetic ester that was initially synthesized in 1935.[A232905,L32539] As a cholinergic agent, bethanechol is similar in structure and pharmacological function to acetylcholine and is used in specific cases when stimulation of the parasympathetic nervous system is necessary.[A232905,L32539] For exampl... | Moderate | 1 | [
[
[
85,
24,
427
]
],
[
[
85,
6,
2720
],
[
2720,
45,
427
]
],
[
[
85,
21,
29316
],
[
29316,
60,
427
]
],
[
[
85,
35,
1442
],
[
1442,
... | [
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bethanechol"
]
],
[
[
"Atropine",
"{u} (Compound) binds {v} (Gene)",
"CHRM3"
],
[
"CHRM3",
"{u} (Gene) is bound by {v} (Compound)",
... | Atropine (Compound) binds CHRM3 (Gene) and CHRM3 (Gene) is bound by Bethanechol (Compound)
Atropine (Compound) causes Sweating (Side Effect) and Sweating (Side Effect) is caused by Bethanechol (Compound)
Atropine (Compound) resembles Scopolamine (Compound) and Atropine may cause a moderate interaction that could exacer... |
DB00421 | DB09133 | 443 | 1,527 | [
"DDInter1707",
"DDInter965"
] | Spironolactone | Iothalamic acid | Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were disco... | Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent. | Moderate | 1 | [
[
[
443,
24,
1527
]
],
[
[
443,
63,
1648
],
[
1648,
24,
1527
]
],
[
[
443,
24,
1512
],
[
1512,
25,
1527
]
],
[
[
443,
63,
1645
],
[
1645,
... | [
[
[
"Spironolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iothalamic acid"
]
],
[
[
"Spironolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
... | Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Iothalamic acid
Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Diclof... |
DB00092 | DB06168 | 58 | 1,531 | [
"DDInter40",
"DDInter281"
] | Alefacept | Canakinumab | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Moderate | 1 | [
[
[
58,
24,
1531
]
],
[
[
58,
23,
1193
],
[
1193,
62,
1531
]
],
[
[
58,
23,
1461
],
[
1461,
23,
1531
]
],
[
[
58,
24,
523
],
[
523,
... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
]
],
[
[
"Alefacept",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
... | Alefacept may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Canakinumab
Alefacept may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitami... |
DB00425 | DB01181 | 558 | 1,532 | [
"DDInter1970",
"DDInter906"
] | Zolpidem | Ifosfamide | Zolpidem, also known as _Ambien_, is a hypnotic drug that was initially approved by the FDA in 1992 [FDA label]. Zolpidem improves sleep in patients with insomnia. It is aimed for use in patients with difficulties initiating sleep. This drug decreases the time to fall asleep (sleep latency), increases the duration of s... | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
558,
24,
1532
]
],
[
[
558,
6,
7524
],
[
7524,
45,
1532
]
],
[
[
558,
21,
28956
],
[
28956,
60,
1532
]
],
[
[
558,
63,
1648
],
[
1648,... | [
[
[
"Zolpidem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Zolpidem",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)",
... | Zolpidem (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Ifosfamide (Compound)
Zolpidem (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Ifosfamide (Compound)
Zolpidem may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Ald... |
DB00738 | DB12161 | 485 | 730 | [
"DDInter1420",
"DDInter512"
] | Pentamidine | Deutetrabenazine | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Deutetrabenazine is a novel, highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor indicated for the management of chorea associated with Huntington’s disease. It is a hexahydro-dimethoxybenzoquinolizine derivative and a deuterated . The presence of deuterium in deutetrabenazine increases the half-lives ... | Moderate | 1 | [
[
[
485,
24,
730
]
],
[
[
485,
23,
112
],
[
112,
23,
730
]
],
[
[
485,
63,
322
],
[
322,
24,
730
]
],
[
[
485,
24,
1559
],
[
1559,
2... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deutetrabenazine"
]
],
[
[
"Pentamidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],... | Pentamidine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Deutetrabenazine
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin ... |
DB00344 | DB08868 | 1,302 | 1,011 | [
"DDInter1543",
"DDInter737"
] | Protriptyline | Fingolimod | Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may ... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
1302,
25,
1011
]
],
[
[
1302,
6,
12523
],
[
12523,
45,
1011
]
],
[
[
1302,
21,
28859
],
[
28859,
60,
1011
]
],
[
[
1302,
23,
112
],
[
... | [
[
[
"Protriptyline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Protriptyline",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"F... | Protriptyline (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Fingolimod (Compound)
Protriptyline (Compound) causes Atrioventricular block (Side Effect) and Atrioventricular block (Side Effect) is caused by Fingolimod (Compound)
Protriptyline may cause a minor interaction that can limit clinical effects wh... |
DB00519 | DB01156 | 1,638 | 593 | [
"DDInter1843",
"DDInter252"
] | Trandolapril | Bupropion | Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiote... | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Moderate | 1 | [
[
[
1638,
24,
593
]
],
[
[
1638,
21,
28757
],
[
28757,
60,
593
]
],
[
[
1638,
63,
322
],
[
322,
24,
593
]
],
[
[
1638,
24,
1383
],
[
1383,... | [
[
[
"Trandolapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bupropion"
]
],
[
[
"Trandolapril",
"{u} (Compound) causes {v} (Side Effect)",
"Dyspepsia"
],
[
"Dyspepsia",
"{u} (Side Effect) is c... | Trandolapril (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Bupropion (Compound)
Trandolapril may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Bupr... |
DB00705 | DB06603 | 441 | 39 | [
"DDInter496",
"DDInter1387"
] | Delavirdine | Panobinostat | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
441,
25,
39
]
],
[
[
441,
63,
506
],
[
506,
24,
39
]
],
[
[
441,
25,
455
],
[
455,
24,
39
]
],
[
[
441,
25,
578
],
[
578,
63,
... | [
[
[
"Delavirdine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextromethorphan"
],
[
"... | Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan and Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Panobinostat
Delavirdine may lead to a major life threatening interaction when taken with Salmeterol and Salme... |
DB00222 | DB00685 | 245 | 1,299 | [
"DDInter825",
"DDInter1887"
] | Glimepiride | Trovafloxacin | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Major | 2 | [
[
[
245,
25,
1299
]
],
[
[
245,
25,
872
],
[
872,
40,
1299
]
],
[
[
245,
21,
29093
],
[
29093,
60,
1299
]
],
[
[
245,
24,
1532
],
[
1532,
... | [
[
[
"Glimepiride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trovafloxacin"
]
],
[
[
"Glimepiride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gemifloxacin"
],
[
"Gemifloxacin",
... | Glimepiride may lead to a major life threatening interaction when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Trovafloxacin (Compound)
Glimepiride (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Trovafloxacin (Compound)
Glimepiride may cause a moderate interaction that c... |
DB00798 | DB05351 | 1,132 | 101 | [
"DDInter815",
"DDInter519"
] | Gentamicin | Dexlansoprazole | Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negat... | Dexlansoprazole is a new-generation proton pump inhibitor (PPI) used for the management of symptoms associated with gastroesophageal reflux disease (GERD) and erosive esophagitis. Dexlansoprazole is the R-enantiomer of , which is composed of a racemic mixture of the R- and S-enantiomers. Compared to the older generatio... | Moderate | 1 | [
[
[
1132,
24,
101
]
],
[
[
1132,
24,
1479
],
[
1479,
23,
101
]
],
[
[
1132,
24,
972
],
[
972,
62,
101
]
],
[
[
1132,
63,
589
],
[
589,
... | [
[
[
"Gentamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexlansoprazole"
]
],
[
[
"Gentamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
... | Gentamicin may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a minor interaction that can limit clinical effects when taken with Dexlansoprazole
Gentamicin may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00759 | DB00819 | 1,620 | 471 | [
"DDInter1783",
"DDInter15"
] | Tetracycline | Acetazolamide | Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some e... | One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its ... | Minor | 0 | [
[
[
1620,
23,
471
]
],
[
[
1620,
62,
997
],
[
997,
40,
471
]
],
[
[
1620,
6,
8374
],
[
8374,
45,
471
]
],
[
[
1620,
1,
1545
],
[
1545,
... | [
[
[
"Tetracycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Acetazolamide"
]
],
[
[
"Tetracycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Methazolamide"
],
... | Tetracycline may cause a minor interaction that can limit clinical effects when taken with Methazolamide and Methazolamide (Compound) resembles Acetazolamide (Compound)
Tetracycline (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Acetazolamide (Compound)
Tetracycline (Compound) resembles Oxytetracycline (C... |
DB01095 | DB12834 | 671 | 148 | [
"DDInter769",
"DDInter1649"
] | Fluvastatin | Secnidazole | Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin belongs to a class of medications called statins and is used to r... | Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent. It is structurally related to other 5-nitroimidazoles, including and , but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class. Secnidazole is selective against many anaerobic Gram-positive ... | Moderate | 1 | [
[
[
671,
24,
148
]
],
[
[
671,
24,
1593
],
[
1593,
24,
148
]
],
[
[
671,
63,
597
],
[
597,
24,
148
]
],
[
[
671,
25,
1510
],
[
1510,
... | [
[
[
"Fluvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secnidazole"
]
],
[
[
"Fluvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
],
[... | Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Secnidazole
Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol an... |
DB00400 | DB06626 | 353 | 263 | [
"DDInter843",
"DDInter147"
] | Griseofulvin | Axitinib | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | Moderate | 1 | [
[
[
353,
24,
263
]
],
[
[
353,
24,
392
],
[
392,
24,
263
]
],
[
[
353,
24,
1593
],
[
1593,
63,
263
]
],
[
[
353,
62,
1101
],
[
1101,
... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Axitinib"
]
],
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
],
[
... | Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Axitinib
Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizot... |
DB01218 | DB08820 | 1,493 | 1,478 | [
"DDInter852",
"DDInter997"
] | Halofantrine | Ivacaftor | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Major | 2 | [
[
[
1493,
25,
1478
]
],
[
[
1493,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
1493,
21,
28762
],
[
28762,
60,
1478
]
],
[
[
1493,
62,
307
],
[
30... | [
[
[
"Halofantrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivacaftor"
]
],
[
[
"Halofantrine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Ivac... | Halofantrine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Halofantrine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Ivacaftor (Compound)
Halofantrine may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modaf... |
DB00054 | DB04896 | 1,432 | 901 | [
"DDInter6",
"DDInter1220"
] | Abciximab | Milnacipran | Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (αv... | Milnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment of depression [F3928, F3934, A175786, A175951]. Furthermore, in 2009 the US FDA approved milnacipran for the a... | Moderate | 1 | [
[
[
1432,
24,
901
]
],
[
[
1432,
24,
41
],
[
41,
1,
901
]
],
[
[
1432,
25,
405
],
[
405,
63,
901
]
],
[
[
1432,
25,
500
],
[
500,
24... | [
[
[
"Abciximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milnacipran"
]
],
[
[
"Abciximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
],
... | Abciximab may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran and Levomilnacipran (Compound) resembles Milnacipran (Compound)
Abciximab may lead to a major life threatening interaction when taken with Acalabrutinib and Acalabrutinib may cause a moderate interaction that could... |
DB00687 | DB00734 | 870 | 1,664 | [
"DDInter747",
"DDInter1605"
] | Fludrocortisone | Risperidone | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Moderate | 1 | [
[
[
870,
24,
1664
]
],
[
[
870,
24,
519
],
[
519,
40,
1664
]
],
[
[
870,
21,
28835
],
[
28835,
60,
1664
]
],
[
[
870,
24,
760
],
[
760,
... | [
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
]
],
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paliperidone"
... | Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone and Paliperidone (Compound) resembles Risperidone (Compound)
Fludrocortisone (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Risperidone (Compound)
Fludrocortisone ma... |
DB00708 | DB14723 | 1,454 | 159 | [
"DDInter1718",
"DDInter1026"
] | Sufentanil | Larotrectinib | Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to w... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
1454,
24,
159
]
],
[
[
1454,
25,
222
],
[
222,
23,
159
]
],
[
[
1454,
24,
98
],
[
98,
24,
159
]
],
[
[
1454,
64,
267
],
[
267,
2... | [
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Sufentanil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
],
[
"Sibutr... | Sufentanil may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somatrem may cause a... |
DB00619 | DB01138 | 1,419 | 804 | [
"DDInter909",
"DDInter1726"
] | Imatinib | Sulfinpyrazone | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties. | Moderate | 1 | [
[
[
1419,
24,
804
]
],
[
[
1419,
24,
998
],
[
998,
1,
804
]
],
[
[
1419,
6,
4973
],
[
4973,
45,
804
]
],
[
[
1419,
63,
608
],
[
608,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfinpyrazone"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylbutazone"
],
... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutazone and Phenylbutazone (Compound) resembles Sulfinpyrazone (Compound)
Imatinib (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sulfinpyrazone (Compound)
Imatinib may cause a moderate interaction that could exa... |
DB00758 | DB03404 | 1,347 | 765 | [
"DDInter413",
"DDInter855"
] | Clopidogrel | Hemin | Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recen... | Hemin (trade name Panhematin) is an iron-containing porphyrin. More specifically, it is protoporphyrin IX containing a ferric iron ion (heme B) with a chloride ligand. | Moderate | 1 | [
[
[
1347,
24,
765
]
],
[
[
1347,
64,
291
],
[
291,
24,
765
]
],
[
[
1347,
63,
1061
],
[
1061,
24,
765
]
],
[
[
1347,
25,
1226
],
[
1226,
... | [
[
[
"Clopidogrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hemin"
]
],
[
[
"Clopidogrel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Argatroban"
],
[
"Argatroban",
... | Clopidogrel may lead to a major life threatening interaction when taken with Argatroban and Argatroban may cause a moderate interaction that could exacerbate diseases when taken with Hemin
Clopidogrel may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause... |
DB00736 | DB05294 | 660 | 1,069 | [
"DDInter676",
"DDInter1917"
] | Esomeprazole | Vandetanib | Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory... | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Minor | 0 | [
[
[
660,
23,
1069
]
],
[
[
660,
64,
1195
],
[
1195,
40,
1069
]
],
[
[
660,
63,
883
],
[
883,
40,
1069
]
],
[
[
660,
6,
8374
],
[
8374,
... | [
[
[
"Esomeprazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vandetanib"
]
],
[
[
"Esomeprazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Erlotinib"
],
[
"Erlotinib... | Esomeprazole may lead to a major life threatening interaction when taken with Erlotinib and Erlotinib (Compound) resembles Vandetanib (Compound)
Esomeprazole may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Vandetanib (Compound)
Esomeprazole (C... |
DB01068 | DB09065 | 1,565 | 760 | [
"DDInter411",
"DDInter424"
] | Clonazepam | Cobicistat | A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop.[FDA Label][L5572,F3763,F3787,F3796] The agent has also been indicated for treating panic disorder.[FDA Label][A175438,L5572,F3763,F3787,F3796] The mechan... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
1565,
24,
760
]
],
[
[
1565,
63,
1101
],
[
1101,
23,
760
]
],
[
[
1565,
40,
523
],
[
523,
24,
760
]
],
[
[
1565,
63,
723
],
[
723,
... | [
[
[
"Clonazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Clonazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Clonazepam may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Clonazepam (Compound) resembles Alprazolam (Compound) and Alprazolam may cause a moderate interaction that could e... |
DB00834 | DB00860 | 932 | 891 | [
"DDInter1215",
"DDInter1513"
] | Mifepristone | Prednisolone | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Major | 2 | [
[
[
932,
25,
891
]
],
[
[
932,
64,
1351
],
[
1351,
40,
891
]
],
[
[
932,
64,
167
],
[
167,
1,
891
]
],
[
[
932,
25,
617
],
[
617,
40... | [
[
[
"Mifepristone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prednisolone"
]
],
[
[
"Mifepristone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Flunisolide"
],
[
"Flunisolide",
... | Mifepristone may lead to a major life threatening interaction when taken with Flunisolide and Flunisolide (Compound) resembles Prednisolone (Compound)
Mifepristone may lead to a major life threatening interaction when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Prednisolone (Compound)
Mifepristone... |
DB00674 | DB09291 | 1,516 | 741 | [
"DDInter802",
"DDInter1615"
] | Galantamine | Rolapitant | Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease. First characterized in the early 1950s, galantamine is a tertiary alkaloid that was extracted from botanical sour... | Rolapitant is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and vomiting (CINV) in adults. Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated by Neurokinin-1 and its l... | Moderate | 1 | [
[
[
1516,
24,
741
]
],
[
[
1516,
24,
1264
],
[
1264,
24,
741
]
],
[
[
1516,
24,
214
],
[
214,
63,
741
]
],
[
[
1516,
63,
322
],
[
322,
... | [
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
]
],
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Galantamine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant
Galantamine may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamat... |
DB00539 | DB00745 | 11 | 307 | [
"DDInter1837",
"DDInter1236"
] | Toremifene | Modafinil | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Moderate | 1 | [
[
[
11,
24,
307
]
],
[
[
11,
25,
1301
],
[
1301,
40,
307
]
],
[
[
11,
64,
362
],
[
362,
40,
307
]
],
[
[
11,
36,
675
],
[
675,
40,
... | [
[
[
"Toremifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Modafinil"
]
],
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Levacetylmethadol"
],
[
"Leva... | Toremifene may lead to a major life threatening interaction when taken with Levacetylmethadol and Levacetylmethadol (Compound) resembles Modafinil (Compound)
Toremifene may lead to a major life threatening interaction when taken with Phenytoin and Phenytoin (Compound) resembles Modafinil (Compound)
Toremifene (Compound... |
DB00594 | DB01060 | 863 | 319 | [
"DDInter68",
"DDInter83"
] | Amiloride | Amoxicillin | A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions... | Amoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972. Amoxicillin has similar activity to [penicillin] and [ampicillin], but leads to higher serum concentrations than ampicillin. Amoxicillin was granted FDA approval on 18 January 1974. | Minor | 0 | [
[
[
863,
23,
319
]
],
[
[
863,
21,
28703
],
[
28703,
60,
319
]
],
[
[
863,
24,
1662
],
[
1662,
63,
319
]
],
[
[
863,
62,
964
],
[
964,
... | [
[
[
"Amiloride",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amoxicillin"
]
],
[
[
"Amiloride",
"{u} (Compound) causes {v} (Side Effect)",
"Pruritus"
],
[
"Pruritus",
"{u} (Side Effect) is caused by... | Amiloride (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Amoxicillin (Compound)
Amiloride may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid and Picosulfuric acid may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00443 | DB00564 | 251 | 1,236 | [
"DDInter195",
"DDInter293"
] | Betamethasone | Carbamazepine | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Moderate | 1 | [
[
[
251,
24,
1236
]
],
[
[
251,
23,
307
],
[
307,
1,
1236
]
],
[
[
251,
63,
362
],
[
362,
1,
1236
]
],
[
[
251,
24,
1335
],
[
1335,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbamazepine"
]
],
[
[
"Betamethasone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
],
... | Betamethasone may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil (Compound) resembles Carbamazepine (Compound)
Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Carbamazepine (Comp... |
DB06589 | DB11689 | 1,250 | 321 | [
"DDInter1400",
"DDInter1659"
] | Pazopanib | Selumetinib | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Activation of the Raf-MEK-ERK signalling pathway is known to be implemented in several types of malignancies; thus, mitogen-activated protein kinase kinase (MEK) inhibitors such as selumetinib are important tools that can target the problematic overactivity of this pathway. Results from clinical trials investigating ea... | Moderate | 1 | [
[
[
1250,
24,
321
]
],
[
[
1250,
25,
982
],
[
982,
63,
321
]
],
[
[
1250,
64,
392
],
[
392,
24,
321
]
],
[
[
1250,
24,
1297
],
[
1297,
... | [
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Selumetinib"
]
],
[
[
"Pazopanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
],
[
"Ivosidenib"... | Pazopanib may lead to a major life threatening interaction when taken with Ivosidenib and Ivosidenib may cause a moderate interaction that could exacerbate diseases when taken with Selumetinib
Pazopanib may lead to a major life threatening interaction when taken with Lapatinib and Lapatinib may cause a moderate interac... |
DB00241 | DB00619 | 288 | 1,419 | [
"DDInter257",
"DDInter909"
] | Butalbital | Imatinib | Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervou... | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Moderate | 1 | [
[
[
288,
24,
1419
]
],
[
[
288,
24,
222
],
[
222,
62,
1419
]
],
[
[
288,
23,
1101
],
[
1101,
23,
1419
]
],
[
[
288,
24,
309
],
[
309,
... | [
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
]
],
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Imatinib
Butalbital may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexarotene... |
DB08873 | DB08875 | 74 | 1,618 | [
"DDInter221",
"DDInter262"
] | Boceprevir | Cabozantinib | Boceprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
74,
25,
1618
]
],
[
[
74,
25,
1135
],
[
1135,
62,
1618
]
],
[
[
74,
63,
723
],
[
723,
24,
1618
]
],
[
[
74,
24,
384
],
[
384,
63... | [
[
[
"Boceprevir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Boceprevir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} m... | Boceprevir may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Boceprevir may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a ... |
DB00468 | DB00976 | 1,424 | 1,056 | [
"DDInter1557",
"DDInter1758"
] | Quinine | Telithromycin | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Major | 2 | [
[
[
1424,
25,
1056
]
],
[
[
1424,
63,
1570
],
[
1570,
40,
1056
]
],
[
[
1424,
6,
7950
],
[
7950,
45,
1056
]
],
[
[
1424,
21,
28681
],
[
28... | [
[
[
"Quinine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Telithromycin"
]
],
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],
[
"Azithromyci... | Quinine may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin (Compound) resembles Telithromycin (Compound)
Quinine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Telithromycin (Compound)
Quinine (Compound) causes Hypersensitivity (Side Effect) and H... |
DB00526 | DB01028 | 1,555 | 1,332 | [
"DDInter1355",
"DDInter1179"
] | Oxaliplatin | Methoxyflurane | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with nitrous oxide to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular... | Moderate | 1 | [
[
[
1555,
24,
1332
]
],
[
[
1555,
6,
7950
],
[
7950,
45,
1332
]
],
[
[
1555,
24,
1448
],
[
1448,
63,
1332
]
],
[
[
1555,
24,
1512
],
[
151... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methoxyflurane"
]
],
[
[
"Oxaliplatin",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compo... | Oxaliplatin (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Methoxyflurane (Compound)
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Streptomycin and Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with Methoxyflurane
Oxal... |
DB01030 | DB11613 | 869 | 1,519 | [
"DDInter1835",
"DDInter1924"
] | Topotecan | Velpatasvir | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Velpatasvir is a Direct-Acting Antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Moderate | 1 | [
[
[
869,
24,
1519
]
],
[
[
869,
24,
594
],
[
594,
24,
1519
]
],
[
[
869,
63,
51
],
[
51,
24,
1519
]
],
[
[
869,
24,
351
],
[
351,
63... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Velpatasvir"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
],
[
... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Bosutinib and Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Velpatasvir
Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Daunorubicin and Daunoru... |
DB00570 | DB12834 | 147 | 148 | [
"DDInter1936",
"DDInter1649"
] | Vinblastine | Secnidazole | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent. It is structurally related to other 5-nitroimidazoles, including and , but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class. Secnidazole is selective against many anaerobic Gram-positive ... | Moderate | 1 | [
[
[
147,
24,
148
]
],
[
[
147,
24,
1593
],
[
1593,
24,
148
]
],
[
[
147,
63,
597
],
[
597,
24,
148
]
],
[
[
147,
25,
1510
],
[
1510,
... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secnidazole"
]
],
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
],
[... | Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Secnidazole
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol an... |
DB00008 | DB01394 | 491 | 1,554 | [
"DDInter1407",
"DDInter431"
] | Peginterferon alfa-2a | Colchicine | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has ... | Moderate | 1 | [
[
[
491,
24,
1554
]
],
[
[
491,
24,
367
],
[
367,
24,
1554
]
],
[
[
491,
24,
375
],
[
375,
63,
1554
]
],
[
[
491,
63,
1057
],
[
1057,
... | [
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Colchicine"
]
],
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Inter... | Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Interferon alfacon-1 and Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Colchicine
Peginterferon alfa-2a may cause a moderate interaction that could exacerbate dise... |
DB00321 | DB06176 | 21 | 1,342 | [
"DDInter78",
"DDInter1616"
] | Amitriptyline | Romidepsin | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Moderate | 1 | [
[
[
21,
24,
1342
]
],
[
[
21,
23,
112
],
[
112,
23,
1342
]
],
[
[
21,
24,
485
],
[
485,
24,
1342
]
],
[
[
21,
24,
1616
],
[
1616,
63... | [
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romidepsin"
]
],
[
[
"Amitriptyline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Amitriptyline may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Romidepsin
Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine a... |
DB00789 | DB01193 | 1,431 | 819 | [
"DDInter796",
"DDInter12"
] | Gadopentetic acid | Acebutolol | A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see pentetic acid), that is given to enhance the image in cranial and spinal MRIs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706) | A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. | Moderate | 1 | [
[
[
1431,
24,
819
]
],
[
[
1431,
24,
887
],
[
887,
1,
819
]
],
[
[
1431,
63,
1121
],
[
1121,
1,
819
]
],
[
[
1431,
21,
28863
],
[
28863,
... | [
[
[
"Gadopentetic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acebutolol"
]
],
[
[
"Gadopentetic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pindolol"
... | Gadopentetic acid may cause a moderate interaction that could exacerbate diseases when taken with Pindolol and Pindolol (Compound) resembles Acebutolol (Compound)
Gadopentetic acid may cause a moderate interaction that could exacerbate diseases when taken with Bisoprolol and Bisoprolol (Compound) resembles Acebutolol (... |
DB00188 | DB01095 | 168 | 671 | [
"DDInter222",
"DDInter769"
] | Bortezomib | Fluvastatin | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin belongs to a class of medications called statins and is used to r... | Moderate | 1 | [
[
[
168,
24,
671
]
],
[
[
168,
24,
788
],
[
788,
40,
671
]
],
[
[
168,
24,
14
],
[
14,
63,
671
]
],
[
[
168,
6,
7950
],
[
7950,
45,
... | [
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
]
],
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
],
[... | Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin (Compound) resembles Fluvastatin (Compound)
Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin and Rosuvastatin may cause a moderate interaction t... |
DB00599 | DB09241 | 682 | 1,629 | [
"DDInter1795",
"DDInter1186"
] | Thiopental | Methylene blue | A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been used in neurosurgical patients to reduce increased intracranial pressure. It does no... | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Moderate | 1 | [
[
[
682,
24,
1629
]
],
[
[
682,
40,
1023
],
[
1023,
24,
1629
]
],
[
[
682,
63,
475
],
[
475,
25,
1629
]
],
[
[
682,
24,
1264
],
[
1264,
... | [
[
[
"Thiopental",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylene blue"
]
],
[
[
"Thiopental",
"{u} (Compound) resembles {v} (Compound)",
"Pentobarbital"
],
[
"Pentobarbital",
"{u} may cause... | Thiopental (Compound) resembles Pentobarbital (Compound) and Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Thiopental may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may lead to a major life threatening ... |
DB00208 | DB00687 | 1,018 | 870 | [
"DDInter1804",
"DDInter747"
] | Ticlopidine | Fludrocortisone | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Minor | 0 | [
[
[
1018,
23,
870
]
],
[
[
1018,
23,
1220
],
[
1220,
40,
870
]
],
[
[
1018,
21,
29180
],
[
29180,
60,
870
]
],
[
[
1018,
23,
115
],
[
115,... | [
[
[
"Ticlopidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Fludrocortisone"
]
],
[
[
"Ticlopidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dexamethasone"
],
... | Ticlopidine may cause a minor interaction that can limit clinical effects when taken with Dexamethasone and Dexamethasone (Compound) resembles Fludrocortisone (Compound)
Ticlopidine (Compound) causes Abdominal distension (Side Effect) and Abdominal distension (Side Effect) is caused by Fludrocortisone (Compound)
Ticlop... |
DB00738 | DB09293 | 485 | 116 | [
"DDInter1420",
"DDInter954"
] | Pentamidine | Iodide I-131 | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
485,
24,
116
]
],
[
[
485,
25,
1487
],
[
1487,
24,
116
]
],
[
[
485,
63,
252
],
[
252,
24,
116
]
],
[
[
485,
23,
1247
],
[
1247,
... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Pentamidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
],
[
... | Pentamidine may lead to a major life threatening interaction when taken with Hydroxychloroquine and Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyzine and ... |
DB00186 | DB08900 | 905 | 1,162 | [
"DDInter1092",
"DDInter1753"
] | Lorazepam | Teduglutide | Lorazepam is a short-acting and rapidly cleared benzodiazepine used commonly as a sedative and anxiolytic. It was developed by DJ Richards, presented and marketed initially by Wyeth Pharmaceuticals in the USA in 1977. The first historic FDA label approval is reported in 1985 by the company Mutual Pharm. | Teduglutide is a glucagon-like peptide-2 (GLP-2) analogue. It is made up of 33 amino acids and is manufactured using a strain of Escherichia coli modified by recombinant DNA technology. Teduglutide differs from GLP-2 by one amino acid (alanine is substituted by glycine). The significance of this substitution is that te... | Moderate | 1 | [
[
[
905,
24,
1162
]
],
[
[
905,
40,
1119
],
[
1119,
24,
1162
]
],
[
[
905,
40,
1119
],
[
1119,
40,
1382
],
[
1382,
24,
1162
]
],
[
[
905,
... | [
[
[
"Lorazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Teduglutide"
]
],
[
[
"Lorazepam",
"{u} (Compound) resembles {v} (Compound)",
"Chlordiazepoxide"
],
[
"Chlordiazepoxide",
"{u} may caus... | Lorazepam (Compound) resembles Chlordiazepoxide (Compound) and Chlordiazepoxide may cause a moderate interaction that could exacerbate diseases when taken with Teduglutide
Lorazepam (Compound) resembles Chlordiazepoxide (Compound) and Chlordiazepoxide (Compound) resembles Midazolam (Compound) and Midazolam may cause a ... |
DB01118 | DB06788 | 33 | 1,616 | [
"DDInter76",
"DDInter864"
] | Amiodarone | Histrelin | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Major | 2 | [
[
[
33,
25,
1616
]
],
[
[
33,
63,
112
],
[
112,
23,
1616
]
],
[
[
33,
25,
1342
],
[
1342,
24,
1616
]
],
[
[
33,
24,
603
],
[
603,
63... | [
[
[
"Amiodarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Histrelin"
]
],
[
[
"Amiodarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
"Metronid... | Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Amiodarone may lead to a major life threatening interaction when taken with Romidepsin and Romidepsin may cau... |
DB00679 | DB09104 | 684 | 286 | [
"DDInter1796",
"DDInter1118"
] | Thioridazine | Magnesium hydroxide | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
684,
24,
286
]
],
[
[
684,
36,
820
],
[
820,
23,
286
]
],
[
[
684,
64,
752
],
[
752,
23,
286
]
],
[
[
684,
1,
146
],
[
146,
23,
... | [
[
[
"Thioridazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Thioridazine",
"{u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken wit... | Thioridazine (Compound) resembles Alimemazine (Compound) and Thioridazine may lead to a major life threatening interaction when taken with Alimemazine and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Thioridazine may lead to a major life threatening inter... |
DB00459 | DB14761 | 640 | 242 | [
"DDInter21",
"DDInter1578"
] | Acitretin | Remdesivir | An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate. | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends o... | Moderate | 1 | [
[
[
640,
24,
242
]
],
[
[
640,
25,
1377
],
[
1377,
24,
242
]
],
[
[
640,
24,
384
],
[
384,
24,
242
]
],
[
[
640,
63,
482
],
[
482,
2... | [
[
[
"Acitretin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
]
],
[
[
"Acitretin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
],
[
"Leflunomide... | Acitretin may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir
Acitretin may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause ... |
DB00690 | DB09420 | 1,216 | 1,074 | [
"DDInter762",
"DDInter953"
] | Flurazepam | Iodide I-123 | A benzodiazepine derivative used mainly as a hypnotic. | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Moderate | 1 | [
[
[
1216,
24,
1074
]
],
[
[
1216,
24,
516
],
[
516,
24,
1074
]
],
[
[
1216,
1,
902
],
[
902,
24,
1074
]
],
[
[
1216,
40,
523
],
[
523,
... | [
[
[
"Flurazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
]
],
[
[
"Flurazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
],
... | Flurazepam may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine and Levocetirizine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123
Flurazepam (Compound) resembles Clobazam (Compound) and Clobazam may cause a moderate interaction that... |
DB01045 | DB04845 | 463 | 309 | [
"DDInter1590",
"DDInter1001"
] | Rifampicin | Ixabepilone | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Moderate | 1 | [
[
[
463,
24,
309
]
],
[
[
463,
6,
8374
],
[
8374,
45,
309
]
],
[
[
463,
64,
1419
],
[
1419,
24,
309
]
],
[
[
463,
24,
1619
],
[
1619,
... | [
[
[
"Rifampicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
]
],
[
[
"Rifampicin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Rifampicin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ixabepilone (Compound)
Rifampicin may lead to a major life threatening interaction when taken with Imatinib and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone
Rifampicin may cause a moderate int... |
DB01320 | DB12332 | 651 | 1,619 | [
"DDInter783",
"DDInter1626"
] | Fosphenytoin | Rucaparib | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
651,
24,
1619
]
],
[
[
651,
40,
307
],
[
307,
23,
1619
]
],
[
[
651,
63,
112
],
[
112,
23,
1619
]
],
[
[
651,
25,
1135
],
[
1135,
... | [
[
[
"Fosphenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Fosphenytoin",
"{u} (Compound) resembles {v} (Compound)",
"Modafinil"
],
[
"Modafinil",
"{u} may cause a minor ... | Fosphenytoin (Compound) resembles Modafinil (Compound) and Modafinil may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Fosphenytoin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can... |
DB00762 | DB11796 | 613 | 1,612 | [
"DDInter973",
"DDInter786"
] | Irinotecan | Fostemsavir | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor. It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir prevents the first step in the... | Moderate | 1 | [
[
[
613,
24,
1612
]
],
[
[
613,
63,
1051
],
[
1051,
23,
1612
]
],
[
[
613,
24,
98
],
[
98,
23,
1612
]
],
[
[
613,
24,
1476
],
[
1476,
... | [
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
]
],
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aminoglutethimide"
],
... | Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Aminoglutethimide and Aminoglutethimide may cause a minor interaction that can limit clinical effects when taken with Fostemsavir
Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Somatrem... |
DB01087 | DB11915 | 1,520 | 1,293 | [
"DDInter1520",
"DDInter1909"
] | Primaquine | Valbenazine | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Moderate | 1 | [
[
[
1520,
24,
1293
]
],
[
[
1520,
62,
112
],
[
112,
23,
1293
]
],
[
[
1520,
63,
521
],
[
521,
24,
1293
]
],
[
[
1520,
24,
392
],
[
392,
... | [
[
[
"Primaquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valbenazine"
]
],
[
[
"Primaquine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Primaquine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Valbenazine
Primaquine may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Gose... |
DB00757 | DB11057 | 1,166 | 720 | [
"DDInter581",
"DDInter1223"
] | Dolasetron | Mineral oil | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
1166,
24,
720
]
],
[
[
1166,
25,
927
],
[
927,
63,
720
]
],
[
[
1166,
25,
1151
],
[
1151,
24,
720
]
],
[
[
1166,
64,
758
],
[
758,
... | [
[
[
"Dolasetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
],
[
"Encorafe... | Dolasetron may lead to a major life threatening interaction when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Dolasetron may lead to a major life threatening interaction when taken with Sunitinib and Sunitinib may cause a moderate int... |
DB00476 | DB00719 | 109 | 1,219 | [
"DDInter608",
"DDInter149"
] | Duloxetine | Azatadine | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Moderate | 1 | [
[
[
109,
24,
1219
]
],
[
[
109,
63,
13
],
[
13,
24,
1219
]
],
[
[
109,
24,
830
],
[
830,
1,
1219
]
],
[
[
109,
24,
1376
],
[
1376,
6... | [
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azatadine"
]
],
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
[... | Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Phenindamine a... |
DB00227 | DB14568 | 1,463 | 982 | [
"DDInter1098",
"DDInter1000"
] | Lovastatin | Ivosidenib | Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disea... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Moderate | 1 | [
[
[
1463,
24,
982
]
],
[
[
1463,
24,
112
],
[
112,
23,
982
]
],
[
[
1463,
63,
168
],
[
168,
23,
982
]
],
[
[
1463,
24,
770
],
[
770,
... | [
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivosidenib"
]
],
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[... | Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bo... |
DB00604 | DB14881 | 1,425 | 180 | [
"DDInter385",
"DDInter1329"
] | Cisapride | Oliceridine | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Major | 2 | [
[
[
1425,
25,
180
]
],
[
[
1425,
23,
112
],
[
112,
23,
180
]
],
[
[
1425,
25,
401
],
[
401,
24,
180
]
],
[
[
1425,
24,
578
],
[
578,
... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Oliceridine"
]
],
[
[
"Cisapride",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidaz... | Cisapride may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Oliceridine
Cisapride may lead to a major life threatening interaction when taken with Promethazine and Promethazine may c... |
DB01211 | DB12500 | 609 | 283 | [
"DDInter393",
"DDInter714"
] | Clarithromycin | Fedratinib | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Major | 2 | [
[
[
609,
25,
283
]
],
[
[
609,
23,
271
],
[
271,
23,
283
]
],
[
[
609,
24,
466
],
[
466,
62,
283
]
],
[
[
609,
25,
351
],
[
351,
23,... | [
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
]
],
[
[
"Clarithromycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mirabegron"
],
[
"Mira... | Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and ... |
DB05239 | DB08868 | 866 | 1,011 | [
"DDInter425",
"DDInter737"
] | Cobimetinib | Fingolimod | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
866,
25,
1011
]
],
[
[
866,
24,
578
],
[
578,
23,
1011
]
],
[
[
866,
64,
915
],
[
915,
24,
1011
]
],
[
[
866,
24,
242
],
[
242,
... | [
[
[
"Cobimetinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Cobimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
],
[
"Ticagrel... | Cobimetinib may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a minor interaction that can limit clinical effects when taken with Fingolimod
Cobimetinib may lead to a major life threatening interaction when taken with Atazanavir and Atazanavir may cause ... |
DB00348 | DB09046 | 254 | 1,094 | [
"DDInter1300",
"DDInter1201"
] | Nitisinone | Metreleptin | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Metreleptin, a recombinant analog of the human hormone leptin, is an orphan drug used to treat complications of leptin deficiency in people with lipodystrophy. Lipodystrophies include a range of disorders characterized by the reduction, absence, or altered distribution of adipose tissue. Complications of lipodystrophy ... | Moderate | 1 | [
[
[
254,
24,
1094
]
],
[
[
254,
24,
578
],
[
578,
24,
1094
]
],
[
[
254,
24,
1155
],
[
1155,
63,
1094
]
],
[
[
254,
63,
576
],
[
576,
... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metreleptin"
]
],
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
],
[
... | Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Metreleptin
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Tucatinib and Tucati... |
DB00439 | DB11901 | 289 | 913 | [
"DDInter341",
"DDInter107"
] | Cerivastatin | Apalutamide | On August 8, 2001 the U.S. Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew Baycol from the U.S. market, due to reports of fatal rhabdomyolysis, a severe adverse reaction from this cholesterol-lowering (lipid-lowering) product. It has also been withdrawn from the Cana... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
289,
24,
913
]
],
[
[
289,
24,
112
],
[
112,
23,
913
]
],
[
[
289,
64,
600
],
[
600,
24,
913
]
],
[
[
289,
25,
609
],
[
609,
24,... | [
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Cerivastatin may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole... |
DB00365 | DB00687 | 839 | 870 | [
"DDInter842",
"DDInter747"
] | Grepafloxacin | Fludrocortisone | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Major | 2 | [
[
[
839,
25,
870
]
],
[
[
839,
25,
1220
],
[
1220,
40,
870
]
],
[
[
839,
24,
303
],
[
303,
40,
870
]
],
[
[
839,
24,
115
],
[
115,
6... | [
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fludrocortisone"
]
],
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexamethasone"
],
[
"Dexamethaso... | Grepafloxacin may lead to a major life threatening interaction when taken with Dexamethasone and Dexamethasone (Compound) resembles Fludrocortisone (Compound)
Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Medroxyprogesterone acetate and Medroxyprogesterone acetate (Compou... |
DB01041 | DB01159 | 770 | 419 | [
"DDInter1789",
"DDInter854"
] | Thalidomide | Halothane | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required... | Moderate | 1 | [
[
[
770,
24,
419
]
],
[
[
770,
6,
6365
],
[
6365,
45,
419
]
],
[
[
770,
63,
112
],
[
112,
23,
419
]
],
[
[
770,
24,
774
],
[
774,
63... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Halothane"
]
],
[
[
"Thalidomide",
"{u} (Compound) binds {v} (Gene)",
"CYP2E1"
],
[
"CYP2E1",
"{u} (Gene) is bound by {v} (Compound)"... | Thalidomide (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Halothane (Compound)
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Halothane
Thalidomide ma... |
DB00792 | DB00909 | 832 | 306 | [
"DDInter1878",
"DDInter1971"
] | Tripelennamine | Zonisamide | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. This... | Major | 2 | [
[
[
832,
25,
306
]
],
[
[
832,
24,
1609
],
[
1609,
63,
306
]
],
[
[
832,
63,
717
],
[
717,
24,
306
]
],
[
[
832,
40,
649
],
[
649,
6... | [
[
[
"Tripelennamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zonisamide"
]
],
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
],
[
... | Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine and Pentoxyverine may cause a moderate interaction that could exacerbate diseases when taken with Zonisamide
Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Trimeth... |
DB00327 | DB00771 | 421 | 262 | [
"DDInter890",
"DDInter397"
] | Hydromorphone | Clidinium | Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of [morphine] that has been available clinically since 1920. Structurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 a... | Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. It inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. It is used for the tr... | Moderate | 1 | [
[
[
421,
24,
262
]
],
[
[
421,
24,
1511
],
[
1511,
63,
262
]
],
[
[
421,
24,
19
],
[
19,
24,
262
]
],
[
[
421,
1,
314
],
[
314,
63,
... | [
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clidinium"
]
],
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
... | Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Clidinium
Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine an... |
DB01049 | DB08824 | 344 | 591 | [
"DDInter663",
"DDInter959"
] | Ergoloid mesylate | Ioflupane I-123 | Ergoloid Mesylate is an equiproportional preparation of three different ergotamantriones: dihydroergocornine, dihydroergocristine, and dihydroergocryptine. All these components are produced by the fungus _Claviceps purpurea_ and are all derivatives of the tetracyclic compound 6-methylergonovine. The derivatives of this... | Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes. | Moderate | 1 | [
[
[
344,
24,
591
]
],
[
[
344,
1,
469
],
[
469,
24,
591
]
],
[
[
344,
1,
469
],
[
469,
21,
29305
],
[
29305,
60,
591
]
],
[
[
344,
4... | [
[
[
"Ergoloid mesylate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioflupane I-123"
]
],
[
[
"Ergoloid mesylate",
"{u} (Compound) resembles {v} (Compound)",
"Bromocriptine"
],
[
"Bromocriptine",
... | Ergoloid mesylate (Compound) resembles Bromocriptine (Compound) and Bromocriptine may cause a moderate interaction that could exacerbate diseases when taken with Ioflupane I-123
Ergoloid mesylate (Compound) resembles Bromocriptine (Compound) and Bromocriptine (Compound) causes Dysgeusia (Side Effect) and Dysgeusia (Sid... |
DB00526 | DB00704 | 1,555 | 267 | [
"DDInter1355",
"DDInter1263"
] | Oxaliplatin | Naltrexone | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Moderate | 1 | [
[
[
1555,
24,
267
]
],
[
[
1555,
24,
522
],
[
522,
24,
267
]
],
[
[
1555,
24,
850
],
[
850,
63,
267
]
],
[
[
1555,
25,
351
],
[
351,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zafirlukast"
],
[... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Zafirlukast and Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedot... |
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