drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00572 | DB00747 | 85 | 1,442 | [
"DDInter136",
"DDInter1647"
] | Atropine | Scopolamine | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | Moderate | 1 | [
[
[
85,
35,
1442
]
],
[
[
85,
1,
11389
],
[
11389,
1,
1442
]
],
[
[
85,
63,
19
],
[
19,
24,
1442
]
],
[
[
85,
1,
11336
],
[
11336,
4... | [
[
[
"Atropine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Scopolamine"
]
],
[
[
"Atropine",
"{u} (Compound) resembles {v} (Compound)",
"Homatropine Methylbromide"
],
... | Atropine (Compound) resembles Scopolamine (Compound) and
Atropine (Compound) resembles Homatropine Methylbromide (Compound) and Homatropine Methylbromide (Compound) resembles Scopolamine (Compound)
Atropine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may c... |
DB00582 | DB11110 | 1,622 | 603 | [
"DDInter1946",
"DDInter1115"
] | Voriconazole | Magnesium citrate | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
1622,
24,
603
]
],
[
[
1622,
25,
57
],
[
57,
24,
603
]
],
[
[
1622,
24,
1616
],
[
1616,
24,
603
]
],
[
[
1622,
25,
484
],
[
484,
... | [
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
[
... | Voriconazole may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Histrelin and... |
DB00317 | DB12332 | 883 | 1,619 | [
"DDInter810",
"DDInter1626"
] | Gefitinib | Rucaparib | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
883,
24,
1619
]
],
[
[
883,
23,
307
],
[
307,
23,
1619
]
],
[
[
883,
24,
1419
],
[
1419,
24,
1619
]
],
[
[
883,
24,
1180
],
[
1180,
... | [
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Gefitinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
],
[
"M... | Gefitinib may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may caus... |
DB00238 | DB09074 | 188 | 1,362 | [
"DDInter1285",
"DDInter1327"
] | Nevirapine | Olaparib | A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class. | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Major | 2 | [
[
[
188,
25,
1362
]
],
[
[
188,
24,
896
],
[
896,
24,
1362
]
],
[
[
188,
62,
168
],
[
168,
24,
1362
]
],
[
[
188,
24,
1619
],
[
1619,
... | [
[
[
"Nevirapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Olaparib"
]
],
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
],
[
"Etoposide",
... | Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Nevirapine may cause a minor interaction that can limit clinical effects when taken with Bortezomib and Bortezomib m... |
DB05773 | DB09065 | 1,047 | 760 | [
"DDInter1848",
"DDInter424"
] | Trastuzumab emtansine | Cobicistat | Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent, DM1. T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-mic... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
1047,
24,
760
]
],
[
[
1047,
24,
1627
],
[
1627,
23,
760
]
],
[
[
1047,
63,
1230
],
[
1230,
23,
760
]
],
[
[
1047,
63,
289
],
[
289,
... | [
[
[
"Trastuzumab emtansine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Trastuzumab emtansine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canna... | Trastuzumab emtansine may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Trastuzumab emtansine may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00358 | DB09048 | 1,010 | 555 | [
"DDInter1140",
"DDInter1284"
] | Mefloquine | Netupitant | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Netupitant is an antiemitic drug approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy. Netupitant is a neurokinin 1 receptor antagonist. The combination drug i... | Moderate | 1 | [
[
[
1010,
24,
555
]
],
[
[
1010,
63,
1101
],
[
1101,
23,
555
]
],
[
[
1010,
24,
283
],
[
283,
62,
555
]
],
[
[
1010,
63,
1181
],
[
1181,
... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Netupitant"
]
],
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Netupitant
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratin... |
DB00679 | DB01218 | 684 | 1,493 | [
"DDInter1796",
"DDInter852"
] | Thioridazine | Halofantrine | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Major | 2 | [
[
[
684,
25,
1493
]
],
[
[
684,
6,
3486
],
[
3486,
45,
1493
]
],
[
[
684,
7,
5998
],
[
5998,
46,
1493
]
],
[
[
684,
18,
2183
],
[
2183,
... | [
[
[
"Thioridazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Halofantrine"
]
],
[
[
"Thioridazine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",
"H... | Thioridazine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Halofantrine (Compound)
Thioridazine (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Halofantrine (Compound)
Thioridazine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Halofantrine (Compound)
Th... |
DB00586 | DB11921 | 1,512 | 1,019 | [
"DDInter537",
"DDInter492"
] | Diclofenac | Deflazacort | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
1512,
24,
1019
]
],
[
[
1512,
63,
443
],
[
443,
24,
1019
]
],
[
[
1512,
24,
959
],
[
959,
24,
1019
]
],
[
[
1512,
24,
1619
],
[
1619,
... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Spironolactone"
],
... | Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Spironolactone and Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Glipizide an... |
DB00774 | DB01284 | 1,577 | 1,042 | [
"DDInter889",
"DDInter1782"
] | Hydroflumethiazide | Tetracosactide | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822) | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Moderate | 1 | [
[
[
1577,
24,
1042
]
],
[
[
1577,
24,
455
],
[
455,
23,
1042
]
],
[
[
1577,
24,
659
],
[
659,
62,
1042
]
],
[
[
1577,
24,
761
],
[
761,
... | [
[
[
"Hydroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
]
],
[
[
"Hydroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmete... | Hydroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a minor interaction that can limit clinical effects when taken with Tetracosactide
Hydroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Vil... |
DB00197 | DB01100 | 1,324 | 1,568 | [
"DDInter1881",
"DDInter1470"
] | Troglitazone | Pimozide | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Moderate | 1 | [
[
[
1324,
24,
1568
]
],
[
[
1324,
24,
455
],
[
455,
24,
1568
]
],
[
[
1324,
24,
222
],
[
222,
63,
1568
]
],
[
[
1324,
63,
912
],
[
912,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pimozide"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
],
[
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Pimozide
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sib... |
DB05316 | DB06788 | 749 | 1,616 | [
"DDInter1467",
"DDInter864"
] | Pimavanserin | Histrelin | Pimavanserin is an atypical antipsychotic indicated for the treatment of psychiatric disorders. Although the exact mechanism of action is unknown, it is thought that pimavanserin interacts with the serotonin receptors, particularly the 5-HT<sub>2A</sub> and HT<sub>2C</sub> receptors. Unlike other atypical antipsychotic... | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Moderate | 1 | [
[
[
749,
24,
1616
]
],
[
[
749,
62,
112
],
[
112,
23,
1616
]
],
[
[
749,
24,
1342
],
[
1342,
24,
1616
]
],
[
[
749,
63,
77
],
[
77,
... | [
[
[
"Pimavanserin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histrelin"
]
],
[
[
"Pimavanserin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Pimavanserin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Pimavanserin may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin and R... |
DB00726 | DB09472 | 1,164 | 1,383 | [
"DDInter1876",
"DDInter1693"
] | Trimipramine | Sodium sulfate | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
1164,
24,
1383
]
],
[
[
1164,
24,
609
],
[
609,
24,
1383
]
],
[
[
1164,
1,
146
],
[
146,
24,
1383
]
],
[
[
1164,
63,
521
],
[
521,
... | [
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
... | Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Trimipramine (Compound) resembles Propiomazine (Compound) and Propiomazine may cause a moderate in... |
DB00002 | DB00992 | 1,284 | 842 | [
"DDInter344",
"DDInter1182"
] | Cetuximab | Methyl aminolevulinate (topical) | Cetuximab is a recombinant chimeric human/mouse IgG1 monoclonal antibody that competitively binds to epidermal growth factor receptor (EGFR) and competitively inhibits the binding of epidermal growth factor (EGF). EGFR is a member of the ErbB family of receptor tyrosine kinases found in both normal and tumour cells; it... | Methyl 5-aminolevulinate is the methyl ester of 5-aminolevulinic acid. A prodrug, it is metabolised to protoporphyrin IX, a photosensitizer, and is used in the photodynamic treatment of non-melanoma skin cancer (including basal cell carcinoma). Topical application (often as the hydrochloride salt) results in an accumul... | Moderate | 1 | [
[
[
1284,
24,
842
]
],
[
[
1284,
24,
612
],
[
612,
24,
842
]
],
[
[
1284,
25,
213
],
[
213,
36,
842
]
],
[
[
1284,
24,
612
],
[
612,
... | [
[
[
"Cetuximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyl aminolevulinate"
]
],
[
[
"Cetuximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Verteporfin"
... | Cetuximab may cause a moderate interaction that could exacerbate diseases when taken with Methyl aminolevulinate
Cetuximab may cause a moderate interaction that could exacerbate diseases when taken with Verteporfin and Verteporfin may cause a moderate interaction that could exacerbate diseases when taken with Methyl am... |
DB00601 | DB06764 | 453 | 1,090 | [
"DDInter1073",
"DDInter1788"
] | Linezolid | Tetryzoline (ophthalmic) | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Tetryzoline is a member of imidazolines and a carboxamidine. It has a role as a sympathomimetic agent and a nasal decongestant. It is a conjugate base of a tetryzoline(1+). | Moderate | 1 | [
[
[
453,
37,
1090
]
],
[
[
453,
24,
144
],
[
144,
63,
1090
]
],
[
[
453,
24,
688
],
[
688,
24,
1090
]
],
[
[
453,
25,
222
],
[
222,
... | [
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v}",
"Tetryzoline"
]
],
[
[
"Linezolid",
"{u} may cause a moderate interaction that could ... | Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Tetryzoline and Linezolid may lead to a major life threatening interaction when taken with Tetryzoline
Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol and Olodaterol may cause a... |
DB00673 | DB00745 | 723 | 307 | [
"DDInter112",
"DDInter1236"
] | Aprepitant | Modafinil | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Minor | 0 | [
[
[
723,
23,
307
]
],
[
[
723,
25,
704
],
[
704,
40,
307
]
],
[
[
723,
63,
362
],
[
362,
40,
307
]
],
[
[
723,
24,
651
],
[
651,
40,... | [
[
[
"Aprepitant",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
]
],
[
[
"Aprepitant",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fentanyl"
],
[
"Fentanyl",
... | Aprepitant may lead to a major life threatening interaction when taken with Fentanyl and Fentanyl (Compound) resembles Modafinil (Compound)
Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Modafinil (Compound)
Aprepitant may cause a ... |
DB01136 | DB01246 | 772 | 820 | [
"DDInter305",
"DDInter45"
] | Carvedilol | Alimemazine | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
772,
24,
820
]
],
[
[
772,
63,
104
],
[
104,
40,
820
]
],
[
[
772,
63,
401
],
[
401,
24,
820
]
],
[
[
772,
6,
8374
],
[
8374,
45... | [
[
[
"Carvedilol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Carvedilol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
[... | Carvedilol may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (Compound)
Carvedilol may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction t... |
DB00188 | DB14783 | 168 | 287 | [
"DDInter222",
"DDInter574"
] | Bortezomib | Diroximel fumarate | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
168,
24,
287
]
],
[
[
168,
23,
1101
],
[
1101,
24,
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]
],
[
[
168,
63,
1560
],
[
1560,
24,
287
]
],
[
[
168,
24,
384
],
[
384,
... | [
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Bortezomib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bexarotene"
],
... | Bortezomib may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase an... |
DB00023 | DB00563 | 305 | 663 | [
"DDInter127",
"DDInter1174"
] | Asparaginase Escherichia coli | Methotrexate | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Moderate | 1 | [
[
[
305,
24,
663
]
],
[
[
305,
24,
328
],
[
328,
62,
663
]
],
[
[
305,
24,
1154
],
[
1154,
63,
663
]
],
[
[
305,
24,
109
],
[
109,
2... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with ... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopurine and Mercaptopurine may cause a minor interaction that can limit clinical effects when taken with Methotrexate
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate ... |
DB01211 | DB15091 | 609 | 676 | [
"DDInter393",
"DDInter1901"
] | Clarithromycin | Upadacitinib | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
609,
25,
676
]
],
[
[
609,
62,
1249
],
[
1249,
24,
676
]
],
[
[
609,
25,
283
],
[
283,
24,
676
]
],
[
[
609,
24,
655
],
[
655,
2... | [
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Clarithromycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Nafcillin"
],
[
"Naf... | Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Nafcillin and Nafcillin may cause a moderate interaction that could exacerbate diseases when taken with Upadacitinib
Clarithromycin may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may ... |
DB00529 | DB01218 | 789 | 1,493 | [
"DDInter779",
"DDInter852"
] | Foscarnet | Halofantrine | An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV. | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Major | 2 | [
[
[
789,
25,
1493
]
],
[
[
789,
21,
28810
],
[
28810,
60,
1493
]
],
[
[
789,
23,
112
],
[
112,
23,
1493
]
],
[
[
789,
24,
770
],
[
770,
... | [
[
[
"Foscarnet",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Halofantrine"
]
],
[
[
"Foscarnet",
"{u} (Compound) causes {v} (Side Effect)",
"Gastrointestinal pain"
],
[
"Gastrointestinal pain",
"{u} (Side Effect... | Foscarnet (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Halofantrine (Compound)
Foscarnet may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effec... |
DB00427 | DB00472 | 1,233 | 758 | [
"DDInter1879",
"DDInter758"
] | Triprolidine | Fluoxetine | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Moderate | 1 | [
[
[
1233,
24,
758
]
],
[
[
1233,
24,
358
],
[
358,
1,
758
]
],
[
[
1233,
24,
109
],
[
109,
40,
758
]
],
[
[
1233,
6,
12523
],
[
12523,
... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxetine"
]
],
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orphenadrine"
],
... | Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Orphenadrine (Compound) resembles Fluoxetine (Compound)
Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxetine (Compound) resembles Fluoxetine (Co... |
DB00275 | DB06595 | 217 | 1,491 | [
"DDInter1330",
"DDInter1214"
] | Olmesartan | Midostaurin | Olmesartan belongs to the angiotensin II receptor blocker (ARB) family of drugs, which also includes [telmisartan], [candesartan], [losartan], [valsartan], and [irbesartan]. ARBs selectively bind to angiotensin receptor 1 (AT1) and prevent the protein angiotensin II from binding and exerting its hypertensive effects, w... | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
217,
24,
1491
]
],
[
[
217,
24,
1662
],
[
1662,
63,
1491
]
],
[
[
217,
63,
176
],
[
176,
24,
1491
]
],
[
[
217,
24,
629
],
[
629,
... | [
[
[
"Olmesartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Olmesartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
],
... | Olmesartan may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid and Picosulfuric acid may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin
Olmesartan may cause a moderate interaction that could exacerbate diseases when taken with Insuli... |
DB00046 | DB04861 | 1,179 | 1,592 | [
"DDInter940",
"DDInter1271"
] | Insulin lispro | Nebivolol | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than [atenolol], [propranolol], or [pindolol]. Nebivolol and... | Moderate | 1 | [
[
[
1179,
24,
1592
]
],
[
[
1179,
24,
1479
],
[
1479,
23,
1592
]
],
[
[
1179,
24,
1450
],
[
1450,
63,
1592
]
],
[
[
1179,
24,
1445
],
[
14... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nebivolol"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a minor interaction that can limit clinical effects when taken with Nebivolol
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00095 | DB12240 | 66 | 110 | [
"DDInter623",
"DDInter1485"
] | Efalizumab | Polatuzumab vedotin | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | Polatuzumab vedotin is a CD79b-directed antibody-drug conjugate that delivers monomethyl auristatin E (MMAE), an anti-mitotic agent, to cancer cells. The drug consists of three components - a humanized immunoglobulin G1 (IgG1) monoclonal antibody specific for human CD79b (polatuzumab), MMAE, and protease-cleavable link... | Moderate | 1 | [
[
[
66,
24,
110
]
],
[
[
66,
24,
1419
],
[
1419,
24,
110
]
],
[
[
66,
63,
58
],
[
58,
24,
110
]
],
[
[
66,
24,
1619
],
[
1619,
63,
... | [
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polatuzumab vedotin"
]
],
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
],
... | Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Polatuzumab vedotin
Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Al... |
DB00332 | DB01246 | 1,089 | 820 | [
"DDInter970",
"DDInter45"
] | Ipratropium | Alimemazine | Ipratropium is a quaternary ammonium derivative of [atropine] that acts as an anticholinergic agent. It is commonly administered through inhalation which allows producing a local effect without presenting a significant systemic absorption. Ipratropium as a therapeutic agent was developed by Boehringer Ingelheim and its... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
1089,
24,
820
]
],
[
[
1089,
24,
358
],
[
358,
24,
820
]
],
[
[
1089,
24,
104
],
[
104,
40,
820
]
],
[
[
1089,
24,
508
],
[
508,
... | [
[
[
"Ipratropium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Ipratropium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orphenadrine"
],
... | Ipratropium may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Ipratropium may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine a... |
DB00281 | DB00555 | 608 | 706 | [
"DDInter1066",
"DDInter1020"
] | Lidocaine | Lamotrigine | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anest... | Lamotrigine is an antiepileptic drug belonging in the phenyltriazine class. It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. Lamotrigine is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. It... | Moderate | 1 | [
[
[
608,
24,
706
]
],
[
[
608,
6,
7953
],
[
7953,
45,
706
]
],
[
[
608,
21,
28719
],
[
28719,
60,
706
]
],
[
[
608,
24,
1010
],
[
1010,
... | [
[
[
"Lidocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lamotrigine"
]
],
[
[
"Lidocaine",
"{u} (Compound) binds {v} (Gene)",
"SCN5A"
],
[
"SCN5A",
"{u} (Gene) is bound by {v} (Compound)",
... | Lidocaine (Compound) binds SCN5A (Gene) and SCN5A (Gene) is bound by Lamotrigine (Compound)
Lidocaine (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Lamotrigine (Compound)
Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine and Mefloquine may ca... |
DB00290 | DB06372 | 329 | 259 | [
"DDInter219",
"DDInter1594"
] | Bleomycin | Rilonacept | A complex of related glycopeptide antibiotics from <i>Streptomyces verticillus</i> consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin. | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
329,
24,
259
]
],
[
[
329,
63,
1461
],
[
1461,
23,
259
]
],
[
[
329,
24,
0
],
[
0,
24,
259
]
],
[
[
329,
24,
1330
],
[
1330,
63,... | [
[
[
"Bleomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Bleomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Bleomycin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Rilonacept
Bleomycin may cause a moderate interaction that could exacerbate diseases when taken with Dactinomycin and Dactinomyc... |
DB00865 | DB11827 | 939 | 433 | [
"DDInter187",
"DDInter669"
] | Benzphetamine | Ertugliflozin | A sympathomimetic agent with properties similar to dextroamphetamine. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222) | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
939,
24,
433
]
],
[
[
939,
24,
959
],
[
959,
24,
433
]
],
[
[
939,
40,
362
],
[
362,
24,
433
]
],
[
[
939,
64,
1466
],
[
1466,
2... | [
[
[
"Benzphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Benzphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
... | Benzphetamine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Benzphetamine (Compound) resembles Phenytoin (Compound) and Phenytoin may cause a moderate interaction that ... |
DB04868 | DB06228 | 478 | 792 | [
"DDInter1293",
"DDInter1609"
] | Nilotinib | Rivaroxaban | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Moderate | 1 | [
[
[
478,
24,
792
]
],
[
[
478,
6,
4973
],
[
4973,
45,
792
]
],
[
[
478,
21,
28703
],
[
28703,
60,
792
]
],
[
[
478,
62,
307
],
[
307,
... | [
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Nilotinib",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Nilotinib (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Rivaroxaban (Compound)
Nilotinib (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Rivaroxaban (Compound)
Nilotinib may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil ma... |
DB09100 | DB09564 | 320 | 1,296 | [
"DDInter1799",
"DDInter930"
] | Thyroid, porcine | Insulin degludec | Thyroid extract is dried and powdered thyroid glands from pigs containing tiiodothyronine (T3) and thyroxine (T4) used to supplement low or absent thyroid activity.[A190831,L11755] Thyroid extract has been described in literature to treat hypothyroidism since 1891 but its use dates back as far as the 6th century. Thyro... | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
320,
24,
1296
]
],
[
[
320,
63,
1411
],
[
1411,
24,
1296
]
],
[
[
320,
24,
1385
],
[
1385,
63,
1296
]
],
[
[
320,
62,
417
],
[
417,
... | [
[
[
"Thyroid, porcine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Thyroid, porcine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutami... | Thyroid, porcine may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Thyroid, porcine may cause a moderate interaction that could exacerbate diseases when taken with S... |
DB00384 | DB00712 | 1,275 | 1,274 | [
"DDInter1859",
"DDInter763"
] | Triamterene | Flurbiprofen | Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side. Since it a... | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Moderate | 1 | [
[
[
1275,
24,
1274
]
],
[
[
1275,
7,
7720
],
[
7720,
45,
1274
]
],
[
[
1275,
21,
28784
],
[
28784,
60,
1274
]
],
[
[
1275,
23,
1127
],
[
1... | [
[
[
"Triamterene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
]
],
[
[
"Triamterene",
"{u} (Compound) upregulates {v} (Gene)",
"PTGS2"
],
[
"PTGS2",
"{u} (Gene) is bound by {v} (Com... | Triamterene (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Flurbiprofen (Compound)
Triamterene (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Flurbiprofen (Compound)
Triamterene may cause a minor interaction that can limit clinical effects when taken w... |
DB00673 | DB00843 | 723 | 479 | [
"DDInter112",
"DDInter583"
] | Aprepitant | Donepezil | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Minor | 0 | [
[
[
723,
23,
479
]
],
[
[
723,
6,
8374
],
[
8374,
45,
479
]
],
[
[
723,
21,
29220
],
[
29220,
60,
479
]
],
[
[
723,
24,
760
],
[
760,
... | [
[
[
"Aprepitant",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Donepezil"
]
],
[
[
"Aprepitant",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Aprepitant (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Donepezil (Compound)
Aprepitant (Compound) causes Abdominal pain upper (Side Effect) and Abdominal pain upper (Side Effect) is caused by Donepezil (Compound)
Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with... |
DB01229 | DB13007 | 973 | 1,060 | [
"DDInter1378",
"DDInter642"
] | Paclitaxel (protein-bound) | Enfortumab vedotin | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Enfortumab vedotin is an antibody-drug conjugate used in the treatment of patients with advanced, treatment-resistant urothelial cancers. It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting chemotherapeutic agent, monomethyl auristatin E (MMAE), joined by a protea... | Moderate | 1 | [
[
[
973,
24,
1060
]
],
[
[
973,
24,
1604
],
[
1604,
23,
1060
]
],
[
[
973,
24,
1593
],
[
1593,
24,
1060
]
],
[
[
973,
63,
14
],
[
14,
... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enfortumab vedotin"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lumacaftor"
],
... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Enfortumab vedotin
Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Lumacaftor and Lumacaftor may cause a minor interaction that can limit clinical effects when taken with Enfortumab vedo... |
DB00495 | DB09065 | 139 | 760 | [
"DDInter1961",
"DDInter424"
] | Zidovudine | Cobicistat | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
139,
24,
760
]
],
[
[
139,
64,
1101
],
[
1101,
23,
760
]
],
[
[
139,
23,
609
],
[
609,
24,
760
]
],
[
[
139,
24,
870
],
[
870,
2... | [
[
[
"Zidovudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Zidovudine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
[
"Bexarotene... | Zidovudine may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Zidovudine may cause a minor interaction that can limit clinical effects when taken with Clarithromycin and Clarithromycin may ca... |
DB00283 | DB01589 | 701 | 481 | [
"DDInter395",
"DDInter1552"
] | Clemastine | Quazepam | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Quazepam is a trifluoroethyl benzodiazepine derivative. It was first approved in the US in 1985 and is used as a hypnotic for the treatment of insomnia. It appears to be unique amongst other benzodiazepine derivatives in its relatively high affinity for sleep-promoting α1 subunit-containing GABA<sub>A</sub> receptors a... | Moderate | 1 | [
[
[
701,
24,
481
]
],
[
[
701,
24,
1216
],
[
1216,
1,
481
]
],
[
[
701,
63,
905
],
[
905,
40,
481
]
],
[
[
701,
63,
1174
],
[
1174,
... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quazepam"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurazepam"
],
[
... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Flurazepam and Flurazepam (Compound) resembles Quazepam (Compound)
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Lorazepam and Lorazepam (Compound) resembles Quazepam (Compound)
Clemas... |
DB09122 | DB14731 | 1,613 | 1,518 | [
"DDInter1409",
"DDInter1741"
] | Peginterferon beta-1a | Tagraxofusp | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Tagraxofusp is a CD123-directed cytotoxin. It is a fusion protein composed of a human interleukin-3 (IL-3) that is genetically fused to the catalytic and translocation domains of truncated diphtheria toxin (DT) produced in _Escherichia coli_.[A253762, A253887, L43702] Tagraxofusp received its first global approval by t... | Moderate | 1 | [
[
[
1613,
24,
1518
]
],
[
[
1613,
63,
1324
],
[
1324,
24,
1518
]
],
[
[
1613,
24,
242
],
[
242,
63,
1518
]
],
[
[
1613,
64,
1070
],
[
1070... | [
[
[
"Peginterferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tagraxofusp"
]
],
[
[
"Peginterferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trog... | Peginterferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Tagraxofusp
Peginterferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken... |
DB01018 | DB01234 | 1,364 | 1,220 | [
"DDInter847",
"DDInter513"
] | Guanfacine | Dexamethasone | Guanfacine, or BS 100-141,[A189838,A189841] is a selective alpha-A2 adrenergic receptor agonist initially indicated for the treatment of hypertension but is now indicated as an extended release tablet for the treatment of ADHD. Guanfacine was first described in the literature in 1974. Guanfacine was granted FDA approva... | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Major | 2 | [
[
[
1364,
25,
1220
]
],
[
[
1364,
63,
870
],
[
870,
1,
1220
]
],
[
[
1364,
63,
175
],
[
175,
40,
1220
]
],
[
[
1364,
24,
617
],
[
617,
... | [
[
[
"Guanfacine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexamethasone"
]
],
[
[
"Guanfacine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
],
[
"Fl... | Guanfacine may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Guanfacine may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Dex... |
DB00951 | DB01259 | 1,072 | 392 | [
"DDInter986",
"DDInter1024"
] | Isoniazid | Lapatinib | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
1072,
24,
392
]
],
[
[
1072,
6,
8374
],
[
8374,
45,
392
]
],
[
[
1072,
21,
28792
],
[
28792,
60,
392
]
],
[
[
1072,
23,
1135
],
[
1135... | [
[
[
"Isoniazid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Isoniazid",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Isoniazid (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lapatinib (Compound)
Isoniazid (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Lapatinib (Compound)
Isoniazid may cause a minor interaction that can limit clinical effects when taken... |
DB00193 | DB00694 | 534 | 51 | [
"DDInter1841",
"DDInter485"
] | Tramadol | Daunorubicin | Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatmen... | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Moderate | 1 | [
[
[
534,
24,
51
]
],
[
[
534,
6,
8374
],
[
8374,
45,
51
]
],
[
[
534,
7,
8779
],
[
8779,
46,
51
]
],
[
[
534,
18,
18226
],
[
18226,
... | [
[
[
"Tramadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Daunorubicin"
]
],
[
[
"Tramadol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Tramadol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Daunorubicin (Compound)
Tramadol (Compound) upregulates CERK (Gene) and CERK (Gene) is upregulated by Daunorubicin (Compound)
Tramadol (Compound) downregulates GDF15 (Gene) and GDF15 (Gene) is downregulated by Daunorubicin (Compound)
Tramadol (Compou... |
DB00626 | DB00994 | 1,441 | 361 | [
"DDInter161",
"DDInter1277"
] | Bacitracin | Neomycin | Bacitracin is a combination of at least 9 bacitracins.[A955,A181952] 60-80% of commercially prepared bacitracin is bacitracin A. The bacillus that produces bacitracin was first isolated from a knee scrape in 1945 from the knee wound of a child named Margaret Tracy. Bacitracin was granted FDA approval on 29 July 1948.[A... | Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as [framycetin], is the most active component of the complex and neomycin C is the isomer o... | Major | 2 | [
[
[
1441,
25,
361
]
],
[
[
1441,
21,
28722
],
[
28722,
60,
361
]
],
[
[
1441,
25,
1132
],
[
1132,
24,
361
]
],
[
[
1441,
24,
242
],
[
242,... | [
[
[
"Bacitracin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Neomycin"
]
],
[
[
"Bacitracin",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused by {v} (Compound)",
... | Bacitracin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Neomycin (Compound)
Bacitracin may lead to a major life threatening interaction when taken with Gentamicin and Gentamicin may cause a moderate interaction that could exacerbate diseases when taken with Neomycin
Bacitracin may cause ... |
DB00816 | DB01128 | 1,674 | 918 | [
"DDInter1346",
"DDInter204"
] | Orciprenaline | Bicalutamide | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Moderate | 1 | [
[
[
1674,
24,
918
]
],
[
[
1674,
24,
129
],
[
129,
40,
918
]
],
[
[
1674,
21,
28642
],
[
28642,
60,
918
]
],
[
[
1674,
24,
786
],
[
786,
... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide (Compound) resembles Bicalutamide (Compound)
Orciprenaline (Compound) causes Shock (Side Effect) and Shock (Side Effect) is caused by Bicalutamide (Compound)
Orciprenaline may cause a moderate int... |
DB00431 | DB01230 | 1,503 | 795 | [
"DDInter1072",
"DDInter1416"
] | Lindane | Pemoline | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | In 2005, the Food and Drug Administration (FDA) withdrew approval for pemoline. In March 2005, Abbott Laboratories (Cylert marketer) had discontinued the production of Cylert arguing economic reasons. | Moderate | 1 | [
[
[
1503,
24,
795
]
],
[
[
1503,
24,
1613
],
[
1613,
63,
795
]
],
[
[
1503,
24,
401
],
[
401,
24,
795
]
],
[
[
1503,
63,
912
],
[
912,
... | [
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pemoline"
]
],
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
],
[... | Lindane may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a and Peginterferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Pemoline
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Prometh... |
DB00035 | DB00515 | 1,314 | 589 | [
"DDInter507",
"DDInter387"
] | Desmopressin | Cisplatin | Desmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body. Upon release... | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Moderate | 1 | [
[
[
1314,
24,
589
]
],
[
[
1314,
6,
7720
],
[
7720,
45,
589
]
],
[
[
1314,
21,
28778
],
[
28778,
60,
589
]
],
[
[
1314,
24,
450
],
[
450,
... | [
[
[
"Desmopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cisplatin"
]
],
[
[
"Desmopressin",
"{u} (Compound) binds {v} (Gene)",
"PTGS2"
],
[
"PTGS2",
"{u} (Gene) is bound by {v} (Compound)"... | Desmopressin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Cisplatin (Compound)
Desmopressin (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Cisplatin (Compound)
Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00787 | DB01249 | 387 | 258 | [
"DDInter25",
"DDInter958"
] | Acyclovir | Iodixanol | Acyclovir is a nucleotide analog antiviral used to treat herpes simplex, _Varicella zoster_, herpes zoster, herpes labialis, and acute herpetic keratitis[L7303,L7315,L7318,L7321,L7324,L7327]. Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young a... | Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents. | Major | 2 | [
[
[
387,
25,
258
]
],
[
[
387,
25,
497
],
[
497,
1,
258
]
],
[
[
387,
18,
5178
],
[
5178,
46,
258
]
],
[
[
387,
7,
5415
],
[
5415,
4... | [
[
[
"Acyclovir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iodixanol"
]
],
[
[
"Acyclovir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
],
[
"Iohexol",
"{u} (Compound)... | Acyclovir may lead to a major life threatening interaction when taken with Iohexol and Iohexol (Compound) resembles Iodixanol (Compound)
Acyclovir (Compound) downregulates XBP1 (Gene) and XBP1 (Gene) is upregulated by Iodixanol (Compound)
Acyclovir (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated b... |
DB00307 | DB06636 | 1,101 | 1,623 | [
"DDInter202",
"DDInter980"
] | Bexarotene | Isavuconazonium | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Moderate | 1 | [
[
[
1101,
24,
1623
]
],
[
[
1101,
24,
466
],
[
466,
62,
1623
]
],
[
[
1101,
23,
1419
],
[
1419,
24,
1623
]
],
[
[
1101,
24,
978
],
[
978,
... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isavuconazonium"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Isavuconazonium
Bexarotene may cause a minor interaction that can limit clinical effects when taken with Imatinib and Ima... |
DB00731 | DB12825 | 1,144 | 1,375 | [
"DDInter1269",
"DDInter1032"
] | Nateglinide | Lefamulin | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Moderate | 1 | [
[
[
1144,
24,
1375
]
],
[
[
1144,
24,
112
],
[
112,
23,
1375
]
],
[
[
1144,
24,
159
],
[
159,
63,
1375
]
],
[
[
1144,
63,
966
],
[
966,
... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
]
],
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lefamulin
Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib an... |
DB00916 | DB01232 | 112 | 1,327 | [
"DDInter1202",
"DDInter1640"
] | Metronidazole | Saquinavir | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Minor | 0 | [
[
[
112,
23,
1327
]
],
[
[
112,
6,
8374
],
[
8374,
45,
1327
]
],
[
[
112,
21,
28893
],
[
28893,
60,
1327
]
],
[
[
112,
24,
770
],
[
770,
... | [
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Saquinavir"
]
],
[
[
"Metronidazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Metronidazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Saquinavir (Compound)
Metronidazole (Compound) causes Hallucination (Side Effect) and Hallucination (Side Effect) is caused by Saquinavir (Compound)
Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Th... |
DB01050 | DB04932 | 848 | 1,564 | [
"DDInter900",
"DDInter491"
] | Ibuprofen | Defibrotide | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Da... | Moderate | 1 | [
[
[
848,
24,
1564
]
],
[
[
848,
23,
297
],
[
297,
62,
1564
]
],
[
[
848,
63,
914
],
[
914,
24,
1564
]
],
[
[
848,
24,
1039
],
[
1039,
... | [
[
[
"Ibuprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Defibrotide"
]
],
[
[
"Ibuprofen",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clo... | Ibuprofen may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Defibrotide
Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Diflunisal and Diflunisal may cause ... |
DB01024 | DB04865 | 1,096 | 4 | [
"DDInter1252",
"DDInter1335"
] | Mycophenolic acid | Omacetaxine mepesuccinate | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
1096,
24,
4
]
],
[
[
1096,
18,
13042
],
[
13042,
46,
4
]
],
[
[
1096,
7,
4811
],
[
4811,
46,
4
]
],
[
[
1096,
7,
2389
],
[
2389,
... | [
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Mycophenolic acid",
"{u} (Compound) downregulates {v} (Gene)",
"HIST1H2BK"
],
[
"HIST1H2BK",
... | Mycophenolic acid (Compound) downregulates HIST1H2BK (Gene) and HIST1H2BK (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Mycophenolic acid (Compound) upregulates DUSP6 (Gene) and DUSP6 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Mycophenolic acid (Compound) upregulates CCDC85B (Gene) an... |
DB00404 | DB00860 | 523 | 891 | [
"DDInter54",
"DDInter1513"
] | Alprazolam | Prednisolone | Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down ... | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Minor | 0 | [
[
[
523,
23,
891
]
],
[
[
523,
23,
1220
],
[
1220,
1,
891
]
],
[
[
523,
23,
1486
],
[
1486,
40,
891
]
],
[
[
523,
6,
8374
],
[
8374,
... | [
[
[
"Alprazolam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Prednisolone"
]
],
[
[
"Alprazolam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dexamethasone"
],
[
... | Alprazolam may cause a minor interaction that can limit clinical effects when taken with Dexamethasone and Dexamethasone (Compound) resembles Prednisolone (Compound)
Alprazolam may cause a minor interaction that can limit clinical effects when taken with Methylprednisolone and Methylprednisolone (Compound) resembles Pr... |
DB00278 | DB08918 | 291 | 41 | [
"DDInter117",
"DDInter1059"
] | Argatroban | Levomilnacipran | Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant sh... | Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake.[A261181, A38560] Levomilnacipran is the more active 1S,2R-enantiomer in the racemate [milnacipran].[A261181, L47956] Once administered, interc... | Moderate | 1 | [
[
[
291,
24,
41
]
],
[
[
291,
24,
901
],
[
901,
40,
41
]
],
[
[
291,
6,
8374
],
[
8374,
45,
41
]
],
[
[
291,
21,
28643
],
[
28643,
6... | [
[
[
"Argatroban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
]
],
[
[
"Argatroban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milnacipran"
],
... | Argatroban may cause a moderate interaction that could exacerbate diseases when taken with Milnacipran and Milnacipran (Compound) resembles Levomilnacipran (Compound)
Argatroban (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Levomilnacipran (Compound)
Argatroban (Compound) causes Infection (Side Effect) a... |
DB06589 | DB12240 | 1,250 | 110 | [
"DDInter1400",
"DDInter1485"
] | Pazopanib | Polatuzumab vedotin | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Polatuzumab vedotin is a CD79b-directed antibody-drug conjugate that delivers monomethyl auristatin E (MMAE), an anti-mitotic agent, to cancer cells. The drug consists of three components - a humanized immunoglobulin G1 (IgG1) monoclonal antibody specific for human CD79b (polatuzumab), MMAE, and protease-cleavable link... | Moderate | 1 | [
[
[
1250,
24,
110
]
],
[
[
1250,
24,
129
],
[
129,
23,
110
]
],
[
[
1250,
63,
467
],
[
467,
24,
110
]
],
[
[
1250,
25,
1593
],
[
1593,
... | [
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polatuzumab vedotin"
]
],
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],... | Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Polatuzumab vedotin
Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin ... |
DB00377 | DB09241 | 1,494 | 1,629 | [
"DDInter1382",
"DDInter1186"
] | Palonosetron | Methylene blue | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Major | 2 | [
[
[
1494,
25,
1629
]
],
[
[
1494,
24,
1052
],
[
1052,
24,
1629
]
],
[
[
1494,
24,
1032
],
[
1032,
63,
1629
]
],
[
[
1494,
25,
851
],
[
851... | [
[
[
"Palonosetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylene blue"
]
],
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ritodrine"
],
[
"Rit... | Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Ritodrine and Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Levosalbutamol ... |
DB00637 | DB01255 | 1,557 | 633 | [
"DDInter128",
"DDInter1078"
] | Astemizole | Lisdexamfetamine | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Moderate | 1 | [
[
[
1557,
24,
633
]
],
[
[
1557,
23,
112
],
[
112,
23,
633
]
],
[
[
1557,
63,
1494
],
[
1494,
24,
633
]
],
[
[
1557,
24,
286
],
[
286,
... | [
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisdexamfetamine"
]
],
[
[
"Astemizole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Astemizole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lisdexamfetamine
Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Palonosetron ... |
DB00307 | DB00635 | 1,101 | 1,573 | [
"DDInter202",
"DDInter1515"
] | Bexarotene | Prednisone | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Moderate | 1 | [
[
[
1101,
24,
1573
]
],
[
[
1101,
24,
175
],
[
175,
40,
1573
]
],
[
[
1101,
24,
1547
],
[
1547,
1,
1573
]
],
[
[
1101,
5,
11555
],
[
11555... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],
[... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Prednisone (Compound)
Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Exemestane and Exemestane (Compound) resembles Prednisone (Comp... |
DB01041 | DB04938 | 770 | 1,423 | [
"DDInter1789",
"DDInter1353"
] | Thalidomide | Ospemifene | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Ospemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. FDA approved on February 26, 2013. | Major | 2 | [
[
[
770,
25,
1423
]
],
[
[
770,
63,
485
],
[
485,
40,
1423
]
],
[
[
770,
6,
6017
],
[
6017,
45,
1423
]
],
[
[
770,
21,
28883
],
[
28883,
... | [
[
[
"Thalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ospemifene"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentamidine"
],
[
"Pentami... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine and Pentamidine (Compound) resembles Ospemifene (Compound)
Thalidomide (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Ospemifene (Compound)
Thalidomide (Compound) causes Skin disorder (Side Effect) and ... |
DB00277 | DB00404 | 1,031 | 523 | [
"DDInter1791",
"DDInter54"
] | Theophylline | Alprazolam | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down ... | Minor | 0 | [
[
[
1031,
23,
523
]
],
[
[
1031,
23,
1418
],
[
1418,
40,
523
]
],
[
[
1031,
62,
905
],
[
905,
40,
523
]
],
[
[
1031,
23,
1382
],
[
1382,
... | [
[
[
"Theophylline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Alprazolam"
]
],
[
[
"Theophylline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Estazolam"
],
[
... | Theophylline may cause a minor interaction that can limit clinical effects when taken with Estazolam and Estazolam (Compound) resembles Alprazolam (Compound)
Theophylline may cause a minor interaction that can limit clinical effects when taken with Lorazepam and Lorazepam (Compound) resembles Alprazolam (Compound)
Theo... |
DB00104 | DB00381 | 966 | 376 | [
"DDInter1323",
"DDInter79"
] | Octreotide | Amlodipine | Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may... | Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial... | Moderate | 1 | [
[
[
966,
24,
376
]
],
[
[
966,
24,
1428
],
[
1428,
1,
376
]
],
[
[
966,
24,
1081
],
[
1081,
40,
376
]
],
[
[
966,
21,
29544
],
[
29544,
... | [
[
[
"Octreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amlodipine"
]
],
[
[
"Octreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isradipine"
],
[
... | Octreotide may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradipine (Compound) resembles Amlodipine (Compound)
Octreotide may cause a moderate interaction that could exacerbate diseases when taken with Nicardipine and Nicardipine (Compound) resembles Amlodipine (Compound... |
DB09407 | DB12455 | 853 | 933 | [
"DDInter1114",
"DDInter1336"
] | Magnesium chloride | Omadacycline | Magnesium chloride salts are highly soluble in water and the hydrated form of magnesium chloride can be extracted from brine or sea water. | Omadacycline has been used in trials studying the treatment of Bacterial Pneumonia, Bacterial Infections, Community-Acquired Infections, and Skin Structures and Soft Tissue Infections. Omadacycline represents a significant advance over the well-known tetracycline family, and has been shown to be highly effective in ani... | Moderate | 1 | [
[
[
853,
24,
933
]
],
[
[
853,
63,
544
],
[
544,
24,
933
]
],
[
[
853,
24,
1473
],
[
1473,
63,
933
]
],
[
[
853,
24,
603
],
[
603,
2... | [
[
[
"Magnesium chloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omadacycline"
]
],
[
[
"Magnesium chloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium... | Magnesium chloride may cause a moderate interaction that could exacerbate diseases when taken with Magnesium sulfate and Magnesium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Omadacycline
Magnesium chloride may cause a moderate interaction that could exacerbate diseases when ... |
DB00708 | DB08895 | 1,454 | 976 | [
"DDInter1718",
"DDInter1825"
] | Sufentanil | Tofacitinib | Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to w... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Moderate | 1 | [
[
[
1454,
24,
976
]
],
[
[
1454,
24,
214
],
[
214,
63,
976
]
],
[
[
1454,
24,
86
],
[
86,
24,
976
]
],
[
[
1454,
63,
723
],
[
723,
2... | [
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib"
]
],
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
],
[... | Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib
Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Miconazole and M... |
DB08820 | DB11978 | 1,478 | 124 | [
"DDInter997",
"DDInter822"
] | Ivacaftor | Glasdegib | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
1478,
24,
124
]
],
[
[
1478,
23,
1135
],
[
1135,
23,
124
]
],
[
[
1478,
63,
1247
],
[
1247,
23,
124
]
],
[
[
1478,
24,
327
],
[
327,
... | [
[
[
"Ivacaftor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Ivacaftor",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
"N... | Ivacaftor may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfameth... |
DB00705 | DB09065 | 441 | 760 | [
"DDInter496",
"DDInter424"
] | Delavirdine | Cobicistat | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
441,
24,
760
]
],
[
[
441,
63,
1101
],
[
1101,
23,
760
]
],
[
[
441,
23,
1374
],
[
1374,
23,
760
]
],
[
[
441,
24,
1041
],
[
1041,
... | [
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Delavirdine may cause a minor interaction that can limit clinical effects when taken with Abiraterone and Abirate... |
DB00988 | DB08882 | 817 | 1,281 | [
"DDInter584",
"DDInter1070"
] | Dopamine | Linagliptin | One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action. | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
817,
24,
1281
]
],
[
[
817,
24,
1002
],
[
1002,
1,
1281
]
],
[
[
817,
21,
28762
],
[
28762,
60,
1281
]
],
[
[
817,
63,
73
],
[
73,
... | [
[
[
"Dopamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Dopamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
],
[
... | Dopamine may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Dopamine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Linagliptin (Compound)
Dopamine may cause a moderate interaction that c... |
DB00443 | DB09381 | 251 | 192 | [
"DDInter195",
"DDInter678"
] | Betamethasone | Esterified estrogens | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of me... | Moderate | 1 | [
[
[
251,
24,
192
]
],
[
[
251,
23,
771
],
[
771,
62,
192
]
],
[
[
251,
24,
5
],
[
5,
24,
192
]
],
[
[
251,
63,
1685
],
[
1685,
24,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esterified estrogens"
]
],
[
[
"Betamethasone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase... | Betamethasone may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase and Hyaluronidase may cause a minor interaction that can limit clinical effects when taken with Esterified estrogens
Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Lir... |
DB00209 | DB06016 | 352 | 1,508 | [
"DDInter1886",
"DDInter300"
] | Trospium | Cariprazine | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary. It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT<sub>1A</sub> receptors and as an antagonist at serotonin 5-HT<sub>2A</sub> receptors. Cariprazine has been investigated in... | Moderate | 1 | [
[
[
352,
24,
1508
]
],
[
[
352,
24,
1507
],
[
1507,
24,
1508
]
],
[
[
352,
24,
849
],
[
849,
63,
1508
]
],
[
[
352,
35,
1192
],
[
1192,
... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cariprazine"
]
],
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dicyclomine"
],
[
... | Trospium may cause a moderate interaction that could exacerbate diseases when taken with Dicyclomine and Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Cariprazine
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyram... |
DB06077 | DB08865 | 879 | 1,593 | [
"DDInter1102",
"DDInter448"
] | Lumateperone | Crizotinib | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Major | 2 | [
[
[
879,
25,
1593
]
],
[
[
879,
25,
283
],
[
283,
62,
1593
]
],
[
[
879,
63,
86
],
[
86,
24,
1593
]
],
[
[
879,
24,
159
],
[
159,
63... | [
[
[
"Lumateperone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
]
],
[
[
"Lumateperone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
],
[
"Fedratinib",
"{... | Lumateperone may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause a minor interaction that can limit clinical effects when taken with Crizotinib
Lumateperone may cause a moderate interaction that could exacerbate diseases when taken with Miconazole and Miconazole may caus... |
DB01181 | DB08868 | 1,532 | 1,011 | [
"DDInter906",
"DDInter737"
] | Ifosfamide | Fingolimod | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
1532,
25,
1011
]
],
[
[
1532,
6,
8374
],
[
8374,
45,
1011
]
],
[
[
1532,
21,
28892
],
[
28892,
60,
1011
]
],
[
[
1532,
63,
867
],
[
86... | [
[
[
"Ifosfamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Ifosfamide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Fingoli... | Ifosfamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fingolimod (Compound)
Ifosfamide (Compound) causes Cardiac arrest (Side Effect) and Cardiac arrest (Side Effect) is caused by Fingolimod (Compound)
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Olanzapin... |
DB00758 | DB01166 | 1,347 | 477 | [
"DDInter413",
"DDInter379"
] | Clopidogrel | Cilostazol | Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recen... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Moderate | 1 | [
[
[
1347,
24,
477
]
],
[
[
1347,
6,
8374
],
[
8374,
45,
477
]
],
[
[
1347,
18,
4303
],
[
4303,
57,
477
]
],
[
[
1347,
21,
28919
],
[
28919... | [
[
[
"Clopidogrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
]
],
[
[
"Clopidogrel",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Clopidogrel (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cilostazol (Compound)
Clopidogrel (Compound) downregulates CLTB (Gene) and CLTB (Gene) is downregulated by Cilostazol (Compound)
Clopidogrel (Compound) causes Arthritis (Side Effect) and Arthritis (Side Effect) is caused by Cilostazol (Compound)
C... |
DB01254 | DB01377 | 1,213 | 1,283 | [
"DDInter484",
"DDInter1119"
] | Dasatinib | Magnesium oxide | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Moderate | 1 | [
[
[
1213,
24,
1283
]
],
[
[
1213,
64,
684
],
[
684,
23,
1283
]
],
[
[
1213,
63,
216
],
[
216,
23,
1283
]
],
[
[
1213,
25,
1468
],
[
1468,
... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium oxide"
]
],
[
[
"Dasatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thioridazine"
],
[
"Thior... | Dasatinib may lead to a major life threatening interaction when taken with Thioridazine and Thioridazine may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Chlorpromazine and Chlorpromazi... |
DB13074 | DB13139 | 877 | 1,032 | [
"DDInter1110",
"DDInter1063"
] | Macimorelin | Levosalbutamol | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). [Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective ... | Major | 2 | [
[
[
877,
25,
1032
]
],
[
[
877,
63,
1573
],
[
1573,
23,
1032
]
],
[
[
877,
64,
1618
],
[
1618,
24,
1032
]
],
[
[
877,
25,
982
],
[
982,
... | [
[
[
"Macimorelin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Levosalbutamol"
]
],
[
[
"Macimorelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
],
[
"Pred... | Macimorelin may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone may cause a minor interaction that can limit clinical effects when taken with Levosalbutamol
Macimorelin may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib ma... |
DB01166 | DB01211 | 477 | 609 | [
"DDInter379",
"DDInter393"
] | Cilostazol | Clarithromycin | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Major | 2 | [
[
[
477,
25,
609
]
],
[
[
477,
63,
1570
],
[
1570,
24,
609
]
],
[
[
477,
6,
7524
],
[
7524,
45,
609
]
],
[
[
477,
7,
5727
],
[
5727,
... | [
[
[
"Cilostazol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
]
],
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],
[
"Azit... | Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Cilostazol (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Clarithromycin (Compound)
Cilost... |
DB00258 | DB04861 | 666 | 1,592 | [
"DDInter270",
"DDInter1271"
] | Calcium acetate | Nebivolol | The chemical compound calcium acetate is the calcium salt of acetic acid. It has been commonly referred to as the acetate of lime. The anhydrous form is very hygroscopic, therefore the monohydrate is the common form. | Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than [atenolol], [propranolol], or [pindolol]. Nebivolol and... | Moderate | 1 | [
[
[
666,
24,
1592
]
],
[
[
666,
21,
28653
],
[
28653,
60,
1592
]
],
[
[
666,
21,
28653
],
[
28653,
60,
578
],
[
578,
62,
1592
]
],
[
[
666... | [
[
[
"Calcium acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nebivolol"
]
],
[
[
"Calcium acetate",
"{u} (Compound) causes {v} (Side Effect)",
"Bradycardia"
],
[
"Bradycardia",
"{u} (Side Ef... | Calcium acetate (Compound) causes Bradycardia (Side Effect) and Bradycardia (Side Effect) is caused by Nebivolol (Compound)
Calcium acetate (Compound) causes Bradycardia (Side Effect) and Bradycardia (Side Effect) is caused by Ticagrelor (Compound) and Ticagrelor may cause a minor interaction that can limit clinical ef... |
DB00861 | DB09472 | 914 | 1,383 | [
"DDInter551",
"DDInter1693"
] | Diflunisal | Sodium sulfate | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
914,
24,
1383
]
],
[
[
914,
24,
477
],
[
477,
24,
1383
]
],
[
[
914,
25,
1618
],
[
1618,
24,
1383
]
],
[
[
914,
24,
877
],
[
877,
... | [
[
[
"Diflunisal",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Diflunisal",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
],
... | Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Cilostazol and Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Diflunisal may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib ma... |
DB01324 | DB06691 | 178 | 849 | [
"DDInter1490",
"DDInter1155"
] | Polythiazide | Mepyramine | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
178,
24,
849
]
],
[
[
178,
63,
1648
],
[
1648,
24,
849
]
],
[
[
178,
1,
1014
],
[
1014,
24,
849
]
],
[
[
178,
24,
407
],
[
407,
... | [
[
[
"Polythiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Polythiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
],
... | Polythiazide may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Polythiazide (Compound) resembles Benzthiazide (Compound) and Benzthiazide may cause a moderate interaction ... |
DB00782 | DB03128 | 1,123 | 140 | [
"DDInter1535",
"DDInter18"
] | Propantheline | Acetylcholine | A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. | A neurotransmitter. Acetylcholine in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. It is generally not used as an administered drug because it is broken ... | Moderate | 1 | [
[
[
1123,
24,
140
]
],
[
[
1123,
24,
1376
],
[
1376,
24,
140
]
],
[
[
1123,
63,
999
],
[
999,
24,
140
]
],
[
[
1123,
24,
1116
],
[
1116,
... | [
[
[
"Propantheline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylcholine"
]
],
[
[
"Propantheline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
... | Propantheline may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Acetylcholine
Propantheline may cause a moderate interaction that could exacerbate diseases when taken with Th... |
DB00530 | DB09291 | 1,195 | 741 | [
"DDInter667",
"DDInter1615"
] | Erlotinib | Rolapitant | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | Rolapitant is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and vomiting (CINV) in adults. Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated by Neurokinin-1 and its l... | Moderate | 1 | [
[
[
1195,
24,
741
]
],
[
[
1195,
24,
159
],
[
159,
63,
741
]
],
[
[
1195,
24,
1671
],
[
1671,
24,
741
]
],
[
[
1195,
63,
353
],
[
353,
... | [
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
]
],
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
[
... | Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant
Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Flibanserin and F... |
DB00899 | DB01069 | 411 | 401 | [
"DDInter1579",
"DDInter1533"
] | Remifentanil | Promethazine | Remifentanil (marketed by Abbott as Ultiva) is a potent ultra short-acting synthetic opioid given to patients during surgery for pain relief and adjunctive to an anaesthetic. Remifentanil is a specific mu-type-opioid receptor agonist which means it reduces sympathetic nervous system tone, and causes respiratory depress... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
411,
24,
401
]
],
[
[
411,
24,
1264
],
[
1264,
63,
401
]
],
[
[
411,
24,
104
],
[
104,
24,
401
]
],
[
[
411,
21,
28787
],
[
28787,
... | [
[
[
"Remifentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Remifentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[... | Remifentanil may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Remifentanil may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Meth... |
DB00005 | DB00497 | 1,057 | 828 | [
"DDInter687",
"DDInter1366"
] | Etanercept | Oxycodone | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.[Label] The f... | Moderate | 1 | [
[
[
1057,
24,
828
]
],
[
[
1057,
25,
812
],
[
812,
63,
828
]
],
[
[
1057,
25,
1648
],
[
1648,
24,
828
]
],
[
[
1057,
24,
58
],
[
58,
... | [
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxycodone"
]
],
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Siltuximab"
],
[
"Siltuximab"... | Etanercept may lead to a major life threatening interaction when taken with Siltuximab and Siltuximab may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone
Etanercept may lead to a major life threatening interaction when taken with Aldesleukin and Aldesleukin may cause a moderate int... |
DB00595 | DB01053 | 1,545 | 514 | [
"DDInter1374",
"DDInter189"
] | Oxytetracycline | Benzylpenicillin | A tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety of clinical conditions. | Benzylpenicillin (Penicillin G) is narrow spectrum antibiotic used to treat infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered intravenously or intramuscularly due to poor oral absorption. Penicillin G may also be used in some cases as prophylaxis against susceptible o... | Moderate | 1 | [
[
[
1545,
24,
514
]
],
[
[
1545,
24,
1390
],
[
1390,
1,
514
]
],
[
[
1545,
63,
703
],
[
703,
1,
514
]
],
[
[
1545,
6,
10612
],
[
10612,
... | [
[
[
"Oxytetracycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzylpenicillin"
]
],
[
[
"Oxytetracycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticarcillin... | Oxytetracycline may cause a moderate interaction that could exacerbate diseases when taken with Ticarcillin and Ticarcillin (Compound) resembles Benzylpenicillin (Compound)
Oxytetracycline may cause a moderate interaction that could exacerbate diseases when taken with Carbenicillin and Carbenicillin (Compound) resemble... |
DB01115 | DB06605 | 336 | 1,409 | [
"DDInter1291",
"DDInter108"
] | Nifedipine | Apixaban | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Moderate | 1 | [
[
[
336,
24,
1409
]
],
[
[
336,
6,
3486
],
[
3486,
45,
1409
]
],
[
[
336,
21,
29666
],
[
29666,
60,
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]
],
[
[
336,
24,
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],
[
1670,... | [
[
[
"Nifedipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apixaban"
]
],
[
[
"Nifedipine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",
... | Nifedipine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Apixaban (Compound)
Nifedipine (Compound) causes Melaena (Side Effect) and Melaena (Side Effect) is caused by Apixaban (Compound)
Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Eliglustat and Eliglustat m... |
DB01166 | DB04868 | 477 | 478 | [
"DDInter379",
"DDInter1293"
] | Cilostazol | Nilotinib | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Moderate | 1 | [
[
[
477,
24,
478
]
],
[
[
477,
25,
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],
[
1468,
63,
478
]
],
[
[
477,
6,
8374
],
[
8374,
45,
478
]
],
[
[
477,
7,
3727
],
[
3727,
... | [
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]
],
[
[
"Cilostazol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ponatinib"
],
[
"Ponatinib",
... | Cilostazol may lead to a major life threatening interaction when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib
Cilostazol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nilotinib (Compound)
Cilostazol (Compound) upregulates MAL... |
DB00305 | DB12674 | 377 | 975 | [
"DDInter1232",
"DDInter1105"
] | Mitomycin | Lurbinectedin | Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of _Streptomyces caespitosus_.[L12867,A193419] It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations, RNA and protein synthesis) by cross-linking the complementary strands of th... | Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative of the marine-derived agent ecteinascidin ([trabectedin]), an anticancer agent fou... | Moderate | 1 | [
[
[
377,
24,
975
]
],
[
[
377,
24,
1488
],
[
1488,
24,
975
]
],
[
[
377,
63,
1257
],
[
1257,
24,
975
]
],
[
[
377,
25,
970
],
[
970,
... | [
[
[
"Mitomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurbinectedin"
]
],
[
[
"Mitomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
],
[
... | Mitomycin may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine and Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin
Mitomycin may cause a moderate interaction that could exacerbate diseases when taken with Pegfilgrastim and ... |
DB00682 | DB01241 | 126 | 1,206 | [
"DDInter1951",
"DDInter812"
] | Warfarin | Gemfibrozil | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Gemfibrozil is a fibric acid agent, similar to [clofibrate], used to treat Type IIb, IV, and V hyperlipidemias.[A185777,L8525] Gemfibrozil is not a first line treatment and is prescribed to patients who have not responded adequately to weight loss, diet, exercise, and other medications. Gemfibrozil was granted FDA appr... | Major | 2 | [
[
[
126,
25,
1206
]
],
[
[
126,
6,
8374
],
[
8374,
45,
1206
]
],
[
[
126,
24,
129
],
[
129,
63,
1206
]
],
[
[
126,
63,
1061
],
[
1061,
... | [
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gemfibrozil"
]
],
[
[
"Warfarin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Gemfibrozi... | Warfarin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Gemfibrozil (Compound)
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Gemfibrozil
Warfarin may cau... |
DB08901 | DB12332 | 1,468 | 1,619 | [
"DDInter1492",
"DDInter1626"
] | Ponatinib | Rucaparib | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
1468,
24,
1619
]
],
[
[
1468,
63,
222
],
[
222,
23,
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]
],
[
[
1468,
62,
307
],
[
307,
23,
1619
]
],
[
[
1468,
23,
1135
],
[
1135,
... | [
[
[
"Ponatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Ponatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Ponatinib may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil ma... |
DB01203 | DB01377 | 699 | 1,283 | [
"DDInter1255",
"DDInter1119"
] | Nadolol | Magnesium oxide | Nadolol is a nonselective beta adrenal receptor blocker that is used to lower blood pressure.[L7922,L7925] Nonselective beta adrenal receptor blockers may no longer be first line in the treatment of hypertension as newer generations of beta adrenal receptor blockers have higher selectivity and offer better rates of adv... | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Minor | 0 | [
[
[
699,
23,
1283
]
],
[
[
699,
63,
167
],
[
167,
23,
1283
]
],
[
[
699,
40,
729
],
[
729,
23,
1283
]
],
[
[
699,
24,
820
],
[
820,
... | [
[
[
"Nadolol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium oxide"
]
],
[
[
"Nadolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
],
[
... | Nadolol may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
Nadolol (Compound) resembles Penbutolol (Compound) and Penbutolol may cause a minor interaction that can... |
DB09052 | DB14711 | 250 | 779 | [
"DDInter220",
"DDInter1680"
] | Blinatumomab | Smallpox (Vaccinia) Vaccine, Live | Blinatumomab is a BiTE-class (bi-specific T-cell engager) constructed monoclonal antibody formed by the recombinant fusion of an anti-CD3 single-chain variable fragment (scFV) and an anti-CD19 scFV through a short peptide linker.[A254836,L44311] CD3 is an antigen expressed on the surface of T-cells, while CD19 is mostl... | The New York City Board of Health strain of _Vaccinia_ is a viral strain used as a component of some smallpox vaccinations. ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this strain. | Major | 2 | [
[
[
250,
25,
779
]
],
[
[
250,
64,
1064
],
[
1064,
25,
779
]
],
[
[
250,
63,
147
],
[
147,
25,
779
]
],
[
[
250,
25,
1259
],
[
1259,
... | [
[
[
"Blinatumomab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Smallpox (Vaccinia) Vaccine, Live"
]
],
[
[
"Blinatumomab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[
... | Blinatumomab may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Smallpox (Vaccinia) Vaccine, Live
Blinatumomab may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine and Vinblast... |
DB01105 | DB09061 | 222 | 1,627 | [
"DDInter1665",
"DDInter284"
] | Sibutramine | Cannabidiol | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
222,
24,
1627
]
],
[
[
222,
62,
723
],
[
723,
23,
1627
]
],
[
[
222,
23,
609
],
[
609,
23,
1627
]
],
[
[
222,
63,
1018
],
[
1018,
... | [
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Sibutramine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Aprepitant"
],
[
... | Sibutramine may cause a minor interaction that can limit clinical effects when taken with Aprepitant and Aprepitant may cause a minor interaction that can limit clinical effects when taken with Cannabidiol
Sibutramine may cause a minor interaction that can limit clinical effects when taken with Clarithromycin and Clari... |
DB00252 | DB09079 | 362 | 1,496 | [
"DDInter1460",
"DDInter1296"
] | Phenytoin | Nintedanib | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Nintedanib is a small molecule kinase inhibitor used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC).[L8453,L8459] It was first approved for use in the United States in 2014. Within the spectrum of idiopathic pulmonary fibrosis trea... | Major | 2 | [
[
[
362,
25,
1496
]
],
[
[
362,
25,
741
],
[
741,
63,
1496
]
],
[
[
362,
24,
609
],
[
609,
24,
1496
]
],
[
[
362,
25,
840
],
[
840,
... | [
[
[
"Phenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nintedanib"
]
],
[
[
"Phenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rolapitant"
],
[
"Rolapitant",
"{u} may... | Phenytoin may lead to a major life threatening interaction when taken with Rolapitant and Rolapitant may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may ... |
DB00445 | DB00570 | 322 | 147 | [
"DDInter655",
"DDInter1936"
] | Epirubicin | Vinblastine | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Moderate | 1 | [
[
[
322,
24,
147
]
],
[
[
322,
63,
134
],
[
134,
24,
147
]
],
[
[
322,
5,
11555
],
[
11555,
44,
147
]
],
[
[
322,
6,
10417
],
[
10417,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinblastine"
]
],
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinorelbine"
],
[
... | Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine
Epirubicin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Vinb... |
DB00334 | DB01259 | 867 | 392 | [
"DDInter1326",
"DDInter1024"
] | Olanzapine | Lapatinib | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
867,
24,
392
]
],
[
[
867,
6,
4973
],
[
4973,
45,
392
]
],
[
[
867,
23,
112
],
[
112,
23,
392
]
],
[
[
867,
24,
918
],
[
918,
24... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Olanzapine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Olanzapine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lapatinib (Compound)
Olanzapine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lapatinib
Olanzapine may cause... |
DB00365 | DB01033 | 839 | 328 | [
"DDInter842",
"DDInter1156"
] | Grepafloxacin | Mercaptopurine | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. | Minor | 0 | [
[
[
839,
23,
328
]
],
[
[
839,
24,
663
],
[
663,
23,
328
]
],
[
[
839,
25,
126
],
[
126,
24,
328
]
],
[
[
839,
24,
384
],
[
384,
63,... | [
[
[
"Grepafloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mercaptopurine"
]
],
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
]... | Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a minor interaction that can limit clinical effects when taken with Mercaptopurine
Grepafloxacin may lead to a major life threatening interaction when taken with Warfarin and Warfarin ma... |
DB01177 | DB10315 | 77 | 1,137 | [
"DDInter904",
"DDInter1127"
] | Idarubicin | Measles virus vaccine live attenuated | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
77,
25,
1137
]
],
[
[
77,
64,
581
],
[
581,
25,
1137
]
],
[
[
77,
24,
384
],
[
384,
25,
1137
]
],
[
[
77,
63,
1184
],
[
1184,
25... | [
[
[
"Idarubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Idarubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Infliximab"
],
[
... | Idarubicin may lead to a major life threatening interaction when taken with Infliximab and Infliximab may lead to a major life threatening interaction when taken with Measles virus vaccine live attenuated
Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisi... |
DB08873 | DB11718 | 74 | 927 | [
"DDInter221",
"DDInter640"
] | Boceprevir | Encorafenib | Boceprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Major | 2 | [
[
[
74,
25,
927
]
],
[
[
74,
24,
659
],
[
659,
24,
927
]
],
[
[
74,
64,
1491
],
[
1491,
24,
927
]
],
[
[
74,
63,
309
],
[
309,
24,
... | [
[
[
"Boceprevir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
]
],
[
[
"Boceprevir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
],
[
"Vilantero... | Boceprevir may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Boceprevir may lead to a major life threatening interaction when taken with Midostaurin and Midostaurin may cau... |
DB00398 | DB14575 | 79 | 733 | [
"DDInter1702",
"DDInter674"
] | Sorafenib | Eslicarbazepine | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Eslicarbazepine is an anti-epileptic medication available commercially as [eslicarbazepine acetate]. | Moderate | 1 | [
[
[
79,
24,
733
]
],
[
[
79,
63,
1101
],
[
1101,
23,
733
]
],
[
[
79,
24,
1264
],
[
1264,
24,
733
]
],
[
[
79,
23,
1135
],
[
1135,
2... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eslicarbazepine"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Eslicarbazepine
Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin ... |
DB01364 | DB01577 | 22 | 1,529 | [
"DDInter650",
"DDInter1161"
] | Ephedrine | Metamfetamine | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Metamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug, and a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. It is a scheduled drug in most countries due to its high potentia... | Moderate | 1 | [
[
[
22,
24,
1529
]
],
[
[
22,
63,
939
],
[
939,
40,
1529
]
],
[
[
22,
75,
1161
],
[
1161,
40,
1529
]
],
[
[
22,
40,
11246
],
[
11246,
... | [
[
[
"Ephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metamfetamine"
]
],
[
[
"Ephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzphetamine"
],
... | Ephedrine may cause a moderate interaction that could exacerbate diseases when taken with Benzphetamine and Benzphetamine (Compound) resembles Metamfetamine (Compound)
Ephedrine (Compound) resembles Selegiline (Compound) and Ephedrine may lead to a major life threatening interaction when taken with Selegiline and Seleg... |
DB00314 | DB00626 | 894 | 1,441 | [
"DDInter288",
"DDInter161"
] | Capreomycin | Bacitracin | Cyclic peptide antibiotic similar to viomycin. It is produced by Streptomyces capreolus. | Bacitracin is a combination of at least 9 bacitracins.[A955,A181952] 60-80% of commercially prepared bacitracin is bacitracin A. The bacillus that produces bacitracin was first isolated from a knee scrape in 1945 from the knee wound of a child named Margaret Tracy. Bacitracin was granted FDA approval on 29 July 1948.[A... | Moderate | 1 | [
[
[
894,
24,
1441
]
],
[
[
894,
24,
1481
],
[
1481,
1,
1441
]
],
[
[
894,
21,
28719
],
[
28719,
60,
1441
]
],
[
[
894,
24,
1555
],
[
1555,... | [
[
[
"Capreomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bacitracin"
]
],
[
[
"Capreomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polymyxin B"
],
[... | Capreomycin may cause a moderate interaction that could exacerbate diseases when taken with Polymyxin B and Polymyxin B (Compound) resembles Bacitracin (Compound)
Capreomycin (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Bacitracin (Compound)
Capreomycin may cause a moderate interaction that ... |
DB00247 | DB01105 | 1,131 | 222 | [
"DDInter1194",
"DDInter1665"
] | Methysergide | Sibutramine | An ergot derivative that is a congener of lysergic acid diethylamide. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize sero... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
1131,
24,
222
]
],
[
[
1131,
21,
28698
],
[
28698,
60,
222
]
],
[
[
1131,
25,
384
],
[
384,
62,
222
]
],
[
[
1131,
24,
159
],
[
159,
... | [
[
[
"Methysergide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Methysergide",
"{u} (Compound) causes {v} (Side Effect)",
"Insomnia"
],
[
"Insomnia",
"{u} (Side Effect) is c... | Methysergide (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Sibutramine (Compound)
Methysergide may lead to a major life threatening interaction when taken with Idelalisib and Idelalisib may cause a minor interaction that can limit clinical effects when taken with Sibutramine
Methyserg... |
DB00907 | DB12825 | 290 | 1,375 | [
"DDInter427",
"DDInter1032"
] | Cocaine (topical) | Lefamulin | Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts. | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Moderate | 1 | [
[
[
290,
24,
1375
]
],
[
[
290,
25,
659
],
[
659,
24,
1375
]
],
[
[
290,
63,
1419
],
[
1419,
24,
1375
]
],
[
[
290,
24,
1478
],
[
1478,
... | [
[
[
"Cocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
]
],
[
[
"Cocaine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vilanterol"
],
[
"Vilanterol",
... | Cocaine may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin
Cocaine may lead to a major life threatening interaction when taken with Vilanterol and Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin
Cocaine may cause a moderate inte... |
DB00572 | DB11160 | 85 | 337 | [
"DDInter136",
"DDInter1459"
] | Atropine | Phenyltoloxamine | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Phenyltoloxamine is an antihistamine drug with sedative and analgesic effects. It is a H1 receptor blocker and a member of the ethanolamine class of antihistaminergic drugs. It is available in combination products that also contain other analgesics and antitussives such as acetaminophen. Phenyltoloxamine citrate is the... | Moderate | 1 | [
[
[
85,
24,
337
]
],
[
[
85,
24,
820
],
[
820,
24,
337
]
],
[
[
85,
63,
999
],
[
999,
24,
337
]
],
[
[
85,
35,
1442
],
[
1442,
24,
... | [
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyltoloxamine"
]
],
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
],
[... | Atropine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Phenyltoloxamine
Atropine may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine ... |
DB00673 | DB01232 | 723 | 1,327 | [
"DDInter112",
"DDInter1640"
] | Aprepitant | Saquinavir | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Moderate | 1 | [
[
[
723,
24,
1327
]
],
[
[
723,
63,
798
],
[
798,
40,
1327
]
],
[
[
723,
24,
915
],
[
915,
40,
1327
]
],
[
[
723,
6,
10215
],
[
10215,
... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saquinavir"
]
],
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nelfinavir"
],
[
... | Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Nelfinavir and Nelfinavir (Compound) resembles Saquinavir (Compound)
Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Atazanavir and Atazanavir (Compound) resembles Saquinavir (Compound)
... |
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