drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00328 | DB00501 | 831 | 752 | [
"DDInter921",
"DDInter380"
] | Indomethacin | Cimetidine | Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlor... | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Minor | 0 | [
[
[
831,
23,
752
]
],
[
[
831,
6,
4973
],
[
4973,
45,
752
]
],
[
[
831,
21,
29134
],
[
29134,
60,
752
]
],
[
[
831,
25,
256
],
[
256,
... | [
[
[
"Indomethacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cimetidine"
]
],
[
[
"Indomethacin",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",... | Indomethacin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Cimetidine (Compound)
Indomethacin (Compound) causes Flatulence (Side Effect) and Flatulence (Side Effect) is caused by Cimetidine (Compound)
Indomethacin may lead to a major life threatening interaction when taken with Prasugrel and Prasugrel may ... |
DB00792 | DB08815 | 832 | 154 | [
"DDInter1878",
"DDInter1104"
] | Tripelennamine | Lurasidone | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States. | Moderate | 1 | [
[
[
832,
24,
154
]
],
[
[
832,
24,
1532
],
[
1532,
24,
154
]
],
[
[
832,
63,
1242
],
[
1242,
24,
154
]
],
[
[
832,
40,
649
],
[
649,
... | [
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurasidone"
]
],
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
],
... | Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Lurasidone
Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine an... |
DB00065 | DB09276 | 581 | 381 | [
"DDInter923",
"DDInter1682"
] | Infliximab | Sodium aurothiomalate | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in active progressive rheumatoid arthritis and of little or no valu... | Moderate | 1 | [
[
[
581,
24,
381
]
],
[
[
581,
25,
1683
],
[
1683,
24,
381
]
],
[
[
581,
63,
491
],
[
491,
24,
381
]
],
[
[
581,
24,
1047
],
[
1047,
... | [
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium aurothiomalate"
]
],
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ustekinumab"
],
[
... | Infliximab may lead to a major life threatening interaction when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Sodium aurothiomalate
Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2a a... |
DB01064 | DB01069 | 1,148 | 401 | [
"DDInter987",
"DDInter1533"
] | Isoprenaline | Promethazine | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
1148,
24,
401
]
],
[
[
1148,
24,
1264
],
[
1264,
63,
401
]
],
[
[
1148,
63,
939
],
[
939,
24,
401
]
],
[
[
1148,
21,
28662
],
[
28662,... | [
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[... | Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Benzphetamine and Ben... |
DB01158 | DB08895 | 1,286 | 976 | [
"DDInter229",
"DDInter1825"
] | Bretylium | Tofacitinib | Bretylium blocks the release of noradrenaline from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibrillation. The primary mode of action for bretylium is thought to be inhibition of vol... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Moderate | 1 | [
[
[
1286,
24,
976
]
],
[
[
1286,
63,
608
],
[
608,
24,
976
]
],
[
[
1286,
1,
61
],
[
61,
1,
768
],
[
768,
24,
976
]
],
[
[
1286,
63,... | [
[
[
"Bretylium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib"
]
],
[
[
"Bretylium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
... | Bretylium may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib
Bretylium (Compound) resembles Edrophonium (Compound) and Edrophonium (Compound) resembles Tapentadol (Compound) a... |
DB01132 | DB08880 | 1,130 | 1,510 | [
"DDInter1472",
"DDInter1771"
] | Pioglitazone | Teriflunomide | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
1130,
25,
1510
]
],
[
[
1130,
24,
1033
],
[
1033,
63,
1510
]
],
[
[
1130,
62,
303
],
[
303,
24,
1510
]
],
[
[
1130,
24,
697
],
[
697,
... | [
[
[
"Pioglitazone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Pioglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
],
[
"Alpe... | Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and Alpelisib may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide
Pioglitazone may cause a minor interaction that can limit clinical effects when taken with Medroxyprogesteron... |
DB00674 | DB11963 | 1,516 | 1,045 | [
"DDInter802",
"DDInter465"
] | Galantamine | Dacomitinib | Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease. First characterized in the early 1950s, galantamine is a tertiary alkaloid that was extracted from botanical sour... | Dacomitinib, designed as (2E)-N-16-4-(piperidin-1-yl) but-2-enamide, is an oral highly selective quinazalone part of the second-generation tyrosine kinase inhibitors which are characterized by the irreversible binding at the ATP domain of the epidermal growth factor receptor family kinase domains. Dacomitinib was devel... | Moderate | 1 | [
[
[
1516,
24,
1045
]
],
[
[
1516,
24,
1376
],
[
1376,
24,
1045
]
],
[
[
1516,
63,
752
],
[
752,
24,
1045
]
],
[
[
1516,
24,
1670
],
[
1670... | [
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dacomitinib"
]
],
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
... | Galantamine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Dacomitinib
Galantamine may cause a moderate interaction that could exacerbate diseases when taken with Cimetidi... |
DB00673 | DB01067 | 723 | 959 | [
"DDInter112",
"DDInter826"
] | Aprepitant | Glipizide | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
723,
24,
959
]
],
[
[
723,
63,
245
],
[
245,
40,
959
]
],
[
[
723,
24,
1411
],
[
1411,
1,
959
]
],
[
[
723,
6,
8374
],
[
8374,
4... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
[
... | Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizide (Compound... |
DB00015 | DB00081 | 582 | 273 | [
"DDInter1585",
"DDInter1838"
] | Reteplase | Tositumomab | Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids p... | Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). | Major | 2 | [
[
[
582,
25,
273
]
],
[
[
582,
23,
539
],
[
539,
62,
273
]
],
[
[
582,
24,
109
],
[
109,
63,
273
]
],
[
[
582,
25,
1618
],
[
1618,
6... | [
[
[
"Reteplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tositumomab"
]
],
[
[
"Reteplase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsicum",
... | Reteplase may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Tositumomab
Reteplase may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxetine may ... |
DB00191 | DB00574 | 73 | 121 | [
"DDInter1447",
"DDInter717"
] | Phentermine | Fenfluramine | Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine. Phentermine has not been reported an addictive potential which allows thi... | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Major | 2 | [
[
[
73,
25,
121
]
],
[
[
73,
24,
1144
],
[
1144,
63,
121
]
],
[
[
73,
24,
127
],
[
127,
24,
121
]
],
[
[
73,
63,
176
],
[
176,
24,
... | [
[
[
"Phentermine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fenfluramine"
]
],
[
[
"Phentermine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
],
[
"Nateg... | Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine
Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Miglitol and Mi... |
DB01610 | DB12001 | 248 | 564 | [
"DDInter1912",
"DDInter7"
] | Valganciclovir | Abemaciclib | Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases. | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Moderate | 1 | [
[
[
248,
24,
564
]
],
[
[
248,
63,
1213
],
[
1213,
24,
564
]
],
[
[
248,
24,
850
],
[
850,
24,
564
]
],
[
[
248,
40,
563
],
[
563,
2... | [
[
[
"Valganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abemaciclib"
]
],
[
[
"Valganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
],
... | Valganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Valganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab ve... |
DB00973 | DB12941 | 1,149 | 466 | [
"DDInter707",
"DDInter481"
] | Ezetimibe | Darolutamide | Ezetimibe is a lipid-lowering compound that inhibits intestinal cholesterol and phytosterol absorption. The discovery and research of this drug began in the early 1990s, after the intravenous administration of radiolabelled ezetimibe in rats revealed that it was being localized within enterocytes of the intestinal vill... | Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen receptor antagonists. Though prior treatment for prostate canc... | Moderate | 1 | [
[
[
1149,
24,
466
]
],
[
[
1149,
24,
484
],
[
484,
23,
466
]
],
[
[
1149,
63,
467
],
[
467,
24,
466
]
],
[
[
1149,
24,
72
],
[
72,
2... | [
[
[
"Ezetimibe",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
]
],
[
[
"Ezetimibe",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
],
[
... | Ezetimibe may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and Entrectinib may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Ezetimibe may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simva... |
DB00593 | DB01246 | 1,464 | 820 | [
"DDInter695",
"DDInter45"
] | Ethosuximide | Alimemazine | An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures. | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
1464,
24,
820
]
],
[
[
1464,
24,
104
],
[
104,
40,
820
]
],
[
[
1464,
24,
401
],
[
401,
24,
820
]
],
[
[
1464,
24,
649
],
[
649,
... | [
[
[
"Ethosuximide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Ethosuximide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
... | Ethosuximide may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (Compound)
Ethosuximide may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interacti... |
DB00572 | DB00924 | 85 | 1,405 | [
"DDInter136",
"DDInter454"
] | Atropine | Cyclobenzaprine | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Cyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961 and has been available for human use since 1977. It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from [Amitriptyline] by only a single double bond.[A185039,A184... | Moderate | 1 | [
[
[
85,
24,
1405
]
],
[
[
85,
63,
1302
],
[
1302,
1,
1405
]
],
[
[
85,
24,
358
],
[
358,
1,
1405
]
],
[
[
85,
24,
401
],
[
401,
63,
... | [
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclobenzaprine"
]
],
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Protriptyline"
],
... | Atropine may cause a moderate interaction that could exacerbate diseases when taken with Protriptyline and Protriptyline (Compound) resembles Cyclobenzaprine (Compound)
Atropine may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Orphenadrine (Compound) resembles Cyclobenzap... |
DB00341 | DB01209 | 1,242 | 1,359 | [
"DDInter343",
"DDInter531"
] | Cetirizine | Dezocine | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | Dezocine is a partial opiate drug and is used for pain management. Dezocine is a very effective alternative to fentanyl when administered during outpatient laparoscopy, although is associated with an increased incidence of postoperative nausea. | Moderate | 1 | [
[
[
1242,
24,
1359
]
],
[
[
1242,
24,
234
],
[
234,
1,
1359
]
],
[
[
1242,
24,
717
],
[
717,
24,
1359
]
],
[
[
1242,
74,
701
],
[
701,
... | [
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dezocine"
]
],
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentazocine"
],
[
... | Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Pentazocine and Pentazocine (Compound) resembles Dezocine (Compound)
Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Trimethobenzamide and Trimethobenzamide may cause a moderate interact... |
DB00011 | DB06414 | 1,451 | 655 | [
"DDInter944",
"DDInter703"
] | Interferon alfa-n1 | Etravirine | Interferon alfa-n1 consists of purified, natural (n is for natural) alpha interferon subtypes, at least two of which are glycosylated. This differs from recombinant alpha interferons, which are individual non-glycosylated proteins produced from individual alpha interferon genes. | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Moderate | 1 | [
[
[
1451,
24,
655
]
],
[
[
1451,
25,
1101
],
[
1101,
23,
655
]
],
[
[
1451,
24,
168
],
[
168,
23,
655
]
],
[
[
1451,
63,
1057
],
[
1057,
... | [
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
]
],
[
[
"Interferon alfa-n1",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
[
... | Interferon alfa-n1 may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Etravirine
Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezo... |
DB00563 | DB04835 | 663 | 1,655 | [
"DDInter1174",
"DDInter1125"
] | Methotrexate | Maraviroc | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Maraviroc (brand-named Selzentry, or Celsentri outside the U.S.) is a chemokine receptor antagonist drug developed by the drug company Pfizer that is designed to act against HIV by interfering with the interaction between HIV and CCR5. It was originally labelled as UK-427857 during development but was assigned the Mara... | Moderate | 1 | [
[
[
663,
24,
1655
]
],
[
[
663,
7,
7247
],
[
7247,
57,
1655
]
],
[
[
663,
21,
28792
],
[
28792,
60,
1655
]
],
[
[
663,
24,
1419
],
[
1419,... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Maraviroc"
]
],
[
[
"Methotrexate",
"{u} (Compound) upregulates {v} (Gene)",
"NPDC1"
],
[
"NPDC1",
"{u} (Gene) is downregulated by {... | Methotrexate (Compound) upregulates NPDC1 (Gene) and NPDC1 (Gene) is downregulated by Maraviroc (Compound)
Methotrexate (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Maraviroc (Compound)
Methotrexate may cause a moderate interaction that could exacerb... |
DB00731 | DB11827 | 1,144 | 433 | [
"DDInter1269",
"DDInter669"
] | Nateglinide | Ertugliflozin | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
1144,
24,
433
]
],
[
[
1144,
62,
1103
],
[
1103,
23,
433
]
],
[
[
1144,
25,
646
],
[
646,
24,
433
]
],
[
[
1144,
63,
1020
],
[
1020,
... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Nateglinide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
],
[... | Nateglinide may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Ertugliflozin
Nateglinide may lead to a major life threatening interaction when taken with Cinoxacin and Cinoxacin may cause a... |
DB00254 | DB09278 | 964 | 852 | [
"DDInter598",
"DDInter24"
] | Doxycycline | Activated charcoal | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | Activated charcoal, or activated carbon, is an amorphous form of carbon prepared from incomplete combustion of carbonaceous organic matter. It is activated by an oxidizing gas flow at high temperature passed over its surface to make a fine network of pores, producing a material with large surface area and high affinity... | Moderate | 1 | [
[
[
964,
24,
852
]
],
[
[
964,
24,
1023
],
[
1023,
24,
852
]
],
[
[
964,
1,
1545
],
[
1545,
24,
852
]
],
[
[
964,
40,
1620
],
[
1620,
... | [
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Activated charcoal"
]
],
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentobarbital"
... | Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Pentobarbital and Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Activated charcoal
Doxycycline (Compound) resembles Oxytetracycline (Compound) and Oxytetracycline may cause a moder... |
DB00691 | DB00704 | 1,058 | 267 | [
"DDInter1237",
"DDInter1263"
] | Moexipril | Naltrexone | Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney prob... | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Moderate | 1 | [
[
[
1058,
24,
267
]
],
[
[
1058,
63,
475
],
[
475,
25,
267
]
],
[
[
1058,
24,
850
],
[
850,
63,
267
]
],
[
[
1058,
63,
1512
],
[
1512,
... | [
[
[
"Moexipril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
]
],
[
[
"Moexipril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Morphine"
],
[
... | Moexipril may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may lead to a major life threatening interaction when taken with Naltrexone
Moexipril may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin and Brentuximab vedoti... |
DB00204 | DB09472 | 228 | 1,383 | [
"DDInter580",
"DDInter1693"
] | Dofetilide | Sodium sulfate | Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter. | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Major | 2 | [
[
[
228,
25,
1383
]
],
[
[
228,
25,
609
],
[
609,
24,
1383
]
],
[
[
228,
64,
521
],
[
521,
24,
1383
]
],
[
[
228,
25,
971
],
[
971,
... | [
[
[
"Dofetilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Dofetilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
],
[
"Clarithromycin",
... | Dofetilide may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Dofetilide may lead to a major life threatening interaction when taken with Goserelin and Goserelin may cause a mod... |
DB06702 | DB12130 | 573 | 1,017 | [
"DDInter731",
"DDInter1094"
] | Fesoterodine | Lorlatinib | Fesoterodine is an antimuscarinic prodrug for the treatment of overactive bladder syndrome. | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
573,
24,
1017
]
],
[
[
573,
63,
1101
],
[
1101,
23,
1017
]
],
[
[
573,
63,
1493
],
[
1493,
24,
1017
]
],
[
[
573,
24,
214
],
[
214,
... | [
[
[
"Fesoterodine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Fesoterodine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
... | Fesoterodine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Fesoterodine may cause a moderate interaction that could exacerbate diseases when taken with Halofantrine and Ha... |
DB00889 | DB06204 | 1,133 | 768 | [
"DDInter840",
"DDInter1746"
] | Granisetron | Tapentadol | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Tapentadol is a centrally-acting synthetic analgesic with a dual mechanism of action. It is a mu-opioid receptor agonist that also inhibits norepinephrine reuptake.[A260721, A36596] Tapentadol was first approved by the FDA on November 20, 2008. The extended-release formulation of tapentadol was also approved by the FDA... | Major | 2 | [
[
[
1133,
25,
768
]
],
[
[
1133,
6,
17589
],
[
17589,
45,
768
]
],
[
[
1133,
21,
28921
],
[
28921,
60,
768
]
],
[
[
1133,
24,
1383
],
[
13... | [
[
[
"Granisetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tapentadol"
]
],
[
[
"Granisetron",
"{u} (Compound) binds {v} (Gene)",
"HTR3A"
],
[
"HTR3A",
"{u} (Gene) is bound by {v} (Compound)",
"Tapenta... | Granisetron (Compound) binds HTR3A (Gene) and HTR3A (Gene) is bound by Tapentadol (Compound)
Granisetron (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Tapentadol (Compound)
Granisetron may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate and... |
DB00414 | DB00841 | 590 | 532 | [
"DDInter16",
"DDInter577"
] | Acetohexamide | Dobutamine | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | A beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery. | Moderate | 1 | [
[
[
590,
24,
532
]
],
[
[
590,
24,
817
],
[
817,
40,
532
]
],
[
[
590,
24,
123
],
[
123,
63,
532
]
],
[
[
590,
63,
73
],
[
73,
24,
... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dobutamine"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dopamine"
],
... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Dopamine and Dopamine (Compound) resembles Dobutamine (Compound)
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Exenatide and Exenatide may cause a moderate interaction that could... |
DB00476 | DB09472 | 109 | 1,383 | [
"DDInter608",
"DDInter1693"
] | Duloxetine | Sodium sulfate | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
109,
24,
1383
]
],
[
[
109,
24,
678
],
[
678,
24,
1383
]
],
[
[
109,
64,
1466
],
[
1466,
24,
1383
]
],
[
[
109,
25,
1133
],
[
1133,
... | [
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxamniquine"
],
... | Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Oxamniquine and Oxamniquine may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Duloxetine may lead to a major life threatening interaction when taken with Phenylpropanolamine and Phenyl... |
DB01083 | DB09122 | 1,142 | 1,613 | [
"DDInter1348",
"DDInter1409"
] | Orlistat | Peginterferon beta-1a | The global prevalence of obesity is increasing rapidly. Obesity-related complications lead to significant personal and economic burden by reducing quality of life and increasing the cost of healthcare. In some individuals, diet and exercise are insufficient to maintain weight loss, and pharmacological or surgical inter... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
1142,
24,
1613
]
],
[
[
1142,
24,
1627
],
[
1627,
24,
1613
]
],
[
[
1142,
63,
267
],
[
267,
24,
1613
]
],
[
[
1142,
24,
242
],
[
242,
... | [
[
[
"Orlistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Orlistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
],
... | Orlistat may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Orlistat may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone a... |
DB01087 | DB11113 | 1,520 | 657 | [
"DDInter1520",
"DDInter307"
] | Primaquine | Castor oil | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of , which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic... | Moderate | 1 | [
[
[
1520,
24,
657
]
],
[
[
1520,
24,
1079
],
[
1079,
24,
657
]
],
[
[
1520,
24,
927
],
[
927,
63,
657
]
],
[
[
1520,
25,
540
],
[
540,
... | [
[
[
"Primaquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Castor oil"
]
],
[
[
"Primaquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telavancin"
],
[
... | Primaquine may cause a moderate interaction that could exacerbate diseases when taken with Telavancin and Telavancin may cause a moderate interaction that could exacerbate diseases when taken with Castor oil
Primaquine may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encor... |
DB01344 | DB11126 | 1,231 | 900 | [
"DDInter1830",
"DDInter276"
] | Tolevamer | Calcium gluconate | Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines. It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among others, H... | Calcium gluconate is used as mineral supplement and medication when there is insufficient calcium in the diet. Supplementation may be done to treat or prevent osteoporosis or rickets, consequences of hypocalcemia. It can also be taken by mouth but is not recommended by injection into a muscle. Calcium Gluconate Injecti... | Moderate | 1 | [
[
[
1231,
24,
900
]
],
[
[
1231,
24,
624
],
[
624,
24,
900
]
],
[
[
1231,
63,
542
],
[
542,
24,
900
]
],
[
[
1231,
24,
1482
],
[
1482,
... | [
[
[
"Tolevamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium gluconate"
]
],
[
[
"Tolevamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liotrix"
],
[
... | Tolevamer may cause a moderate interaction that could exacerbate diseases when taken with Liotrix and Liotrix may cause a moderate interaction that could exacerbate diseases when taken with Calcium gluconate
Tolevamer may cause a moderate interaction that could exacerbate diseases when taken with Levothyroxine and Levo... |
DB00637 | DB01128 | 1,557 | 918 | [
"DDInter128",
"DDInter204"
] | Astemizole | Bicalutamide | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Moderate | 1 | [
[
[
1557,
24,
918
]
],
[
[
1557,
24,
129
],
[
129,
40,
918
]
],
[
[
1557,
6,
8374
],
[
8374,
45,
918
]
],
[
[
1557,
23,
112
],
[
112,
... | [
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
]
],
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
... | Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide (Compound) resembles Bicalutamide (Compound)
Astemizole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bicalutamide (Compound)
Astemizole may cause a minor interaction that can limit cl... |
DB00081 | DB06700 | 273 | 643 | [
"DDInter1838",
"DDInter511"
] | Tositumomab | Desvenlafaxine | Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). | Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of ad... | Moderate | 1 | [
[
[
273,
24,
643
]
],
[
[
273,
24,
1100
],
[
1100,
1,
643
]
],
[
[
273,
25,
292
],
[
292,
63,
643
]
],
[
[
273,
37,
1274
],
[
1274,
... | [
[
[
"Tositumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desvenlafaxine"
]
],
[
[
"Tositumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venlafaxine"
],
... | Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine (Compound) resembles Desvenlafaxine (Compound)
Tositumomab may lead to a major life threatening interaction when taken with Regorafenib and Regorafenib may cause a moderate interaction that could exac... |
DB04868 | DB10315 | 478 | 1,137 | [
"DDInter1293",
"DDInter1127"
] | Nilotinib | Measles virus vaccine live attenuated | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
478,
25,
1137
]
],
[
[
478,
63,
617
],
[
617,
24,
1137
]
],
[
[
478,
24,
119
],
[
119,
64,
1137
]
],
[
[
478,
64,
581
],
[
581,
... | [
[
[
"Nilotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Budesonide"
]... | Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Measles virus vaccine live attenuated
Nilotinib may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00987 | DB01181 | 1,224 | 1,532 | [
"DDInter461",
"DDInter906"
] | Cytarabine (liposomal) | Ifosfamide | Cytarabine can cause developmental toxicity according to an independent committee of scientific and health experts. | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
1224,
24,
1532
]
],
[
[
1224,
5,
11555
],
[
11555,
44,
1532
]
],
[
[
1224,
6,
8374
],
[
8374,
45,
1532
]
],
[
[
1224,
18,
17480
],
[
1... | [
[
[
"Cytarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Cytarabine",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Diseas... | Cytarabine may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide
Cytarabine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Ifosfamide (Compound)
Cytarabine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ifosfamide (Compoun... |
DB00544 | DB00570 | 970 | 147 | [
"DDInter757",
"DDInter1936"
] | Fluorouracil | Vinblastine | A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Minor | 0 | [
[
[
970,
23,
147
]
],
[
[
970,
63,
134
],
[
134,
24,
147
]
],
[
[
970,
5,
11579
],
[
11579,
44,
147
]
],
[
[
970,
6,
11145
],
[
11145,
... | [
[
[
"Fluorouracil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vinblastine"
]
],
[
[
"Fluorouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinorelbine"
],
... | Fluorouracil may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine
Fluorouracil (Compound) treats breast cancer (Disease) and breast cancer (Disease) is treated by Vinblastin... |
DB01169 | DB08868 | 57 | 1,011 | [
"DDInter120",
"DDInter737"
] | Arsenic trioxide | Fingolimod | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
57,
25,
1011
]
],
[
[
57,
6,
8374
],
[
8374,
45,
1011
]
],
[
[
57,
62,
1247
],
[
1247,
23,
1011
]
],
[
[
57,
24,
144
],
[
144,
6... | [
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Arsenic trioxide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Arsenic trioxide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fingolimod (Compound)
Arsenic trioxide may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Fingolimo... |
DB05239 | DB11988 | 866 | 270 | [
"DDInter425",
"DDInter1321"
] | Cobimetinib | Ocrelizumab | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
866,
24,
270
]
],
[
[
866,
24,
1491
],
[
1491,
24,
270
]
],
[
[
866,
25,
800
],
[
800,
24,
270
]
],
[
[
866,
24,
287
],
[
287,
6... | [
[
[
"Cobimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Cobimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
],
... | Cobimetinib may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin and Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab
Cobimetinib may lead to a major life threatening interaction when taken with Duvelisib and Duvelisib may cau... |
DB00574 | DB01577 | 121 | 1,529 | [
"DDInter717",
"DDInter1161"
] | Fenfluramine | Metamfetamine | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Metamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug, and a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. It is a scheduled drug in most countries due to its high potentia... | Major | 2 | [
[
[
121,
25,
1529
]
],
[
[
121,
25,
939
],
[
939,
40,
1529
]
],
[
[
121,
64,
80
],
[
80,
40,
1529
]
],
[
[
121,
25,
93
],
[
93,
1,
... | [
[
[
"Fenfluramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Metamfetamine"
]
],
[
[
"Fenfluramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Benzphetamine"
],
[
"Benzphetamine",... | Fenfluramine may lead to a major life threatening interaction when taken with Benzphetamine and Benzphetamine (Compound) resembles Metamfetamine (Compound)
Fenfluramine may lead to a major life threatening interaction when taken with Amphetamine and Amphetamine (Compound) resembles Metamfetamine (Compound)
Fenfluramine... |
DB00420 | DB01105 | 508 | 222 | [
"DDInter1532",
"DDInter1665"
] | Promazine | Sibutramine | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
508,
24,
222
]
],
[
[
508,
6,
8374
],
[
8374,
45,
222
]
],
[
[
508,
18,
4930
],
[
4930,
57,
222
]
],
[
[
508,
63,
600
],
[
600,
... | [
[
[
"Promazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Promazine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Promazine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sibutramine (Compound)
Promazine (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Sibutramine (Compound)
Promazine may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may ... |
DB09389 | DB11828 | 517 | 1,406 | [
"DDInter1315",
"DDInter1281"
] | Norgestrel | Neratinib | Norgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantiomer ([levonorgestrel]) is biologically active. | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Moderate | 1 | [
[
[
517,
24,
1406
]
],
[
[
517,
63,
392
],
[
392,
24,
1406
]
],
[
[
517,
24,
1619
],
[
1619,
63,
1406
]
],
[
[
517,
62,
14
],
[
14,
... | [
[
[
"Norgestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Neratinib"
]
],
[
[
"Norgestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
],
[
... | Norgestrel may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Neratinib
Norgestrel may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib ... |
DB00279 | DB00491 | 1,152 | 127 | [
"DDInter1074",
"DDInter1217"
] | Liothyronine | Miglitol | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | Moderate | 1 | [
[
[
1152,
24,
127
]
],
[
[
1152,
24,
984
],
[
984,
63,
127
]
],
[
[
1152,
63,
245
],
[
245,
24,
127
]
],
[
[
1152,
1,
624
],
[
624,
... | [
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miglitol"
]
],
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Danazol"
],
[
... | Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Danazol and Danazol may cause a moderate interaction that could exacerbate diseases when taken with Miglitol
Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiri... |
DB01193 | DB01284 | 819 | 1,042 | [
"DDInter12",
"DDInter1782"
] | Acebutolol | Tetracosactide | A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Moderate | 1 | [
[
[
819,
24,
1042
]
],
[
[
819,
63,
455
],
[
455,
23,
1042
]
],
[
[
819,
24,
659
],
[
659,
62,
1042
]
],
[
[
819,
63,
1144
],
[
1144,
... | [
[
[
"Acebutolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
]
],
[
[
"Acebutolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
],
... | Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a minor interaction that can limit clinical effects when taken with Tetracosactide
Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vila... |
DB00445 | DB10343 | 322 | 962 | [
"DDInter655",
"DDInter160"
] | Epirubicin | Bacillus calmette-guerin substrain tice live antigen | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Bacillus calmette-guerin substrain tice live antigen is a vaccine containing attenuated live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of *Mycobacterium bovis* for percutaneous use. It is administered to prevent the development of tuberculosis. | Major | 2 | [
[
[
322,
25,
962
]
],
[
[
322,
64,
1057
],
[
1057,
25,
962
]
],
[
[
322,
24,
1342
],
[
1342,
25,
962
]
],
[
[
322,
24,
270
],
[
270,
... | [
[
[
"Epirubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bacillus calmette-guerin substrain tice live antigen"
]
],
[
[
"Epirubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
... | Epirubicin may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Bacillus calmette-guerin substrain tice live antigen
Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Romidepsi... |
DB00060 | DB00277 | 912 | 1,031 | [
"DDInter947",
"DDInter1791"
] | Interferon beta-1a | Theophylline | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Moderate | 1 | [
[
[
912,
24,
1031
]
],
[
[
912,
24,
424
],
[
424,
62,
1031
]
],
[
[
912,
24,
1072
],
[
1072,
63,
1031
]
],
[
[
912,
24,
581
],
[
581,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Theophylline"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Riluzole"... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Riluzole and Riluzole may cause a minor interaction that can limit clinical effects when taken with Theophylline
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Isoniazid... |
DB01175 | DB01240 | 318 | 885 | [
"DDInter672",
"DDInter657"
] | Escitalopram | Epoprostenol | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Moderate | 1 | [
[
[
318,
24,
885
]
],
[
[
318,
63,
1061
],
[
1061,
1,
885
]
],
[
[
318,
21,
28684
],
[
28684,
60,
885
]
],
[
[
318,
63,
1512
],
[
1512,
... | [
[
[
"Escitalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
]
],
[
[
"Escitalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
... | Escitalopram may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil (Compound) resembles Epoprostenol (Compound)
Escitalopram (Compound) causes Hypoaesthesia (Side Effect) and Hypoaesthesia (Side Effect) is caused by Epoprostenol (Compound)
Escitalopram may cause a... |
DB01100 | DB06282 | 1,568 | 516 | [
"DDInter1470",
"DDInter1053"
] | Pimozide | Levocetirizine | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
1568,
24,
516
]
],
[
[
1568,
63,
701
],
[
701,
24,
516
]
],
[
[
1568,
24,
407
],
[
407,
63,
516
]
],
[
[
1568,
24,
649
],
[
649,
... | [
[
[
"Pimozide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Pimozide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
[
... | Pimozide may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine
Pimozide may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may c... |
DB00909 | DB00986 | 306 | 1,192 | [
"DDInter1971",
"DDInter834"
] | Zonisamide | Glycopyrronium | Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. This... | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | Major | 2 | [
[
[
306,
25,
1192
]
],
[
[
306,
25,
1511
],
[
1511,
63,
1192
]
],
[
[
306,
64,
262
],
[
262,
24,
1192
]
],
[
[
306,
21,
28906
],
[
28906,
... | [
[
[
"Zonisamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glycopyrronium"
]
],
[
[
"Zonisamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mepenzolate"
],
[
"Mepenzolate",
... | Zonisamide may lead to a major life threatening interaction when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium
Zonisamide may lead to a major life threatening interaction when taken with Clidinium and Clidinium may cause a moderate ... |
DB00501 | DB01009 | 752 | 935 | [
"DDInter380",
"DDInter1009"
] | Cimetidine | Ketoprofen | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Minor | 0 | [
[
[
752,
23,
935
]
],
[
[
752,
24,
1523
],
[
1523,
40,
935
]
],
[
[
752,
63,
847
],
[
847,
1,
935
]
],
[
[
752,
23,
1274
],
[
1274,
... | [
[
[
"Cimetidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ketoprofen"
]
],
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Labetalol"
],
[
... | Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol (Compound) resembles Ketoprofen (Compound)
Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine (Compound) resembles Ketoprofen (Compound)
... |
DB00848 | DB08904 | 281 | 375 | [
"DDInter1044",
"DDInter342"
] | Levamisole | Certolizumab pegol | Levamisole is an antihelminthic drug that was commonly used for the treatment of parasitic, viral, and bacterial infections. It was manufactured by _Janssen_ and first used in 1969 as an agent to treat worm infestations Levamisole was approved by the FDA in 1990 as an adjuvant treatment for colon cancer. Prior to this,... | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Major | 2 | [
[
[
281,
25,
375
]
],
[
[
281,
24,
1367
],
[
1367,
63,
375
]
],
[
[
281,
63,
208
],
[
208,
24,
375
]
],
[
[
281,
24,
651
],
[
651,
2... | [
[
[
"Levamisole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Levamisole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis B Vaccine (Recombinant)"... | Levamisole may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant) and Hepatitis B Vaccine (Recombinant) may cause a moderate interaction that could exacerbate diseases when taken with Certolizumab pegol
Levamisole may cause a moderate interaction that could exa... |
DB06643 | DB09074 | 1,136 | 1,362 | [
"DDInter500",
"DDInter1327"
] | Denosumab | Olaparib | Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL inhibitor approved to prevent osteoclast-mediated bone loss.... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
1136,
24,
1362
]
],
[
[
1136,
63,
896
],
[
896,
24,
1362
]
],
[
[
1136,
24,
250
],
[
250,
24,
1362
]
],
[
[
1136,
24,
1619
],
[
1619,
... | [
[
[
"Denosumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Denosumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
],
[
"... | Denosumab may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Denosumab may cause a moderate interaction that could exacerbate diseases when taken with Blinatumomab and Blinatumom... |
DB00647 | DB08865 | 675 | 1,593 | [
"DDInter528",
"DDInter448"
] | Dextropropoxyphene | Crizotinib | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Major | 2 | [
[
[
675,
25,
1593
]
],
[
[
675,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
675,
7,
10809
],
[
10809,
46,
1593
]
],
[
[
675,
18,
3023
],
[
3023,
... | [
[
[
"Dextropropoxyphene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
]
],
[
[
"Dextropropoxyphene",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Dextropropoxyphene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Dextropropoxyphene (Compound) upregulates RBKS (Gene) and RBKS (Gene) is upregulated by Crizotinib (Compound)
Dextropropoxyphene (Compound) downregulates RUVBL1 (Gene) and RUVBL1 (Gene) is downregulated by Crizotinib (... |
DB00283 | DB00564 | 701 | 1,236 | [
"DDInter395",
"DDInter293"
] | Clemastine | Carbamazepine | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Moderate | 1 | [
[
[
701,
24,
1236
]
],
[
[
701,
24,
1405
],
[
1405,
40,
1236
]
],
[
[
701,
24,
508
],
[
508,
1,
1236
]
],
[
[
701,
63,
362
],
[
362,
... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbamazepine"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclobenzaprine"
],
... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Cyclobenzaprine and Cyclobenzaprine (Compound) resembles Carbamazepine (Compound)
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine (Compound) resembles Carbamazepi... |
DB01229 | DB11979 | 973 | 1,320 | [
"DDInter1377",
"DDInter625"
] | Paclitaxel | Elagolix | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
973,
24,
1320
]
],
[
[
973,
63,
168
],
[
168,
23,
1320
]
],
[
[
973,
63,
79
],
[
79,
24,
1320
]
],
[
[
973,
24,
129
],
[
129,
24... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Elagolix
Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib m... |
DB00427 | DB01221 | 1,233 | 1,190 | [
"DDInter1879",
"DDInter1007"
] | Triprolidine | Ketamine | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Ketamine is an NMDA receptor antagonist with a potent anesthetic effect. It was developed in 1963 as a replacement for phencyclidine (PCP) by Calvin Stevens at Parke Davis Laboratories. It started being used for veterinary purposes in Belgium and in 1964 was proven that compared to PCP, it produced minor hallucinogenic... | Moderate | 1 | [
[
[
1233,
24,
1190
]
],
[
[
1233,
24,
649
],
[
649,
63,
1190
]
],
[
[
1233,
24,
530
],
[
530,
24,
1190
]
],
[
[
1233,
63,
1594
],
[
1594,
... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketamine"
]
],
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],
[
... | Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Ketamine
Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and Dron... |
DB01246 | DB11718 | 820 | 927 | [
"DDInter45",
"DDInter640"
] | Alimemazine | Encorafenib | A phenothiazine derivative that is used as an antipruritic. | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
820,
24,
927
]
],
[
[
820,
62,
112
],
[
112,
23,
927
]
],
[
[
820,
24,
720
],
[
720,
24,
927
]
],
[
[
820,
74,
216
],
[
216,
24,... | [
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Alimemazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Alimemazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Encorafenib
Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil and ... |
DB00092 | DB08895 | 58 | 976 | [
"DDInter40",
"DDInter1825"
] | Alefacept | Tofacitinib | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
58,
25,
976
]
],
[
[
58,
23,
1193
],
[
1193,
62,
976
]
],
[
[
58,
23,
1461
],
[
1461,
23,
976
]
],
[
[
58,
24,
200
],
[
200,
63,... | [
[
[
"Alefacept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Alefacept",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Zinc gluc... | Alefacept may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Tofacitinib
Alefacept may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitami... |
DB00581 | DB04946 | 355 | 924 | [
"DDInter1018",
"DDInter907"
] | Lactulose | Iloperidone | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Moderate | 1 | [
[
[
355,
24,
924
]
],
[
[
355,
24,
1664
],
[
1664,
1,
924
]
],
[
[
355,
24,
1425
],
[
1425,
25,
924
]
],
[
[
355,
24,
519
],
[
519,
... | [
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloperidone"
]
],
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
[
... | Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Iloperidone (Compound)
Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Cisapride and Cisapride may lead to a major life threatening interac... |
DB01253 | DB01612 | 628 | 1,637 | [
"DDInter664",
"DDInter92"
] | Ergometrine | Amyl Nitrite | An ergot alkaloid with uterine and vascular smooth muscle contractile properties. | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Moderate | 1 | [
[
[
628,
24,
1637
]
],
[
[
628,
1,
588
],
[
588,
24,
1637
]
],
[
[
628,
1,
588
],
[
588,
1,
469
],
[
469,
24,
1637
]
],
[
[
628,
1,
... | [
[
[
"Ergometrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Ergometrine",
"{u} (Compound) resembles {v} (Compound)",
"Methylergometrine"
],
[
"Methylergometrine",
"{u} m... | Ergometrine (Compound) resembles Methylergometrine (Compound) and Methyl
Ergometrine (Compound) resembles Methylergometrine (Compound) and Methylergometrine (Compound) resembles Bromocriptine (Compound) and Bromocriptine may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Ergome... |
DB00372 | DB01023 | 999 | 409 | [
"DDInter1793",
"DDInter716"
] | Thiethylperazine | Felodipine | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte... | Moderate | 1 | [
[
[
999,
24,
409
]
],
[
[
999,
24,
376
],
[
376,
40,
409
]
],
[
[
999,
63,
1428
],
[
1428,
1,
409
]
],
[
[
999,
24,
854
],
[
854,
1,... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Felodipine"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amlodipine"
... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Amlodipine and Amlodipine (Compound) resembles Felodipine (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradipine (Compound) resembles Felodipine... |
DB09073 | DB09098 | 951 | 98 | [
"DDInter1379",
"DDInter1700"
] | Palbociclib | Somatrem | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
951,
24,
98
]
],
[
[
951,
62,
271
],
[
271,
23,
98
]
],
[
[
951,
63,
336
],
[
336,
24,
98
]
],
[
[
951,
24,
159
],
[
159,
63,
... | [
[
[
"Palbociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Palbociclib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mirabegron"
],
[
... | Palbociclib may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Somatrem
Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Nifedipine and Nifedipine... |
DB00850 | DB01619 | 1,630 | 830 | [
"DDInter1432",
"DDInter1441"
] | Perphenazine | Phenindamine | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Moderate | 1 | [
[
[
1630,
24,
830
]
],
[
[
1630,
24,
537
],
[
537,
40,
830
]
],
[
[
1630,
63,
1219
],
[
1219,
40,
830
]
],
[
[
1630,
63,
13
],
[
13,
... | [
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
]
],
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
],
... | Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) resembles Phenindamine (Compound)
Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine and Azatadine (Compound) resembles Phenindamine (Compou... |
DB00489 | DB00651 | 17 | 746 | [
"DDInter1704",
"DDInter613"
] | Sotalol | Dyphylline | Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventric... | Dyphylline is a theophylline derivative with broncho- and vasodilator properties. It is typically used in the management of asthma, cardiac dyspnea, and bronchitis. | Major | 2 | [
[
[
17,
25,
746
]
],
[
[
17,
64,
1031
],
[
1031,
1,
746
]
],
[
[
17,
21,
28642
],
[
28642,
60,
746
]
],
[
[
17,
24,
22
],
[
22,
62,
... | [
[
[
"Sotalol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dyphylline"
]
],
[
[
"Sotalol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Theophylline"
],
[
"Theophylline",
"{u} (Co... | Sotalol may lead to a major life threatening interaction when taken with Theophylline and Theophylline (Compound) resembles Dyphylline (Compound)
Sotalol (Compound) causes Shock (Side Effect) and Shock (Side Effect) is caused by Dyphylline (Compound)
Sotalol may cause a moderate interaction that could exacerbate diseas... |
DB00280 | DB14724 | 494 | 48 | [
"DDInter575",
"DDInter634"
] | Disopyramide | Emapalumab | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Emapalumab, also known as NI-0501, is a fully human monoclonal antibody that targets interferon gamma. Emapalumab development was sponsored by NovImmune SA, further developed by Sobi and FDA approved on November 20, 2018.[A38676, L4840] The approval of emapalumab was followed by the designation of orphan drug, priority... | Moderate | 1 | [
[
[
494,
24,
48
]
],
[
[
494,
40,
576
],
[
576,
24,
48
]
],
[
[
494,
23,
126
],
[
126,
24,
48
]
],
[
[
494,
63,
1031
],
[
1031,
24,
... | [
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Emapalumab"
]
],
[
[
"Disopyramide",
"{u} (Compound) resembles {v} (Compound)",
"Methadone"
],
[
"Methadone",
"{u} may cause a moder... | Disopyramide (Compound) resembles Methadone (Compound) and Methadone may cause a moderate interaction that could exacerbate diseases when taken with Emapalumab
Disopyramide may cause a minor interaction that can limit clinical effects when taken with Warfarin and Warfarin may cause a moderate interaction that could exa... |
DB00983 | DB06616 | 480 | 594 | [
"DDInter776",
"DDInter224"
] | Formoterol | Bosutinib | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Moderate | 1 | [
[
[
480,
24,
594
]
],
[
[
480,
21,
29231
],
[
29231,
60,
594
]
],
[
[
480,
63,
1559
],
[
1559,
24,
594
]
],
[
[
480,
24,
786
],
[
786,
... | [
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
]
],
[
[
"Formoterol",
"{u} (Compound) causes {v} (Side Effect)",
"Cardiac disorder"
],
[
"Cardiac disorder",
"{u} (Side Ef... | Formoterol (Compound) causes Cardiac disorder (Side Effect) and Cardiac disorder (Side Effect) is caused by Bosutinib (Compound)
Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Famotidine and Famotidine may cause a moderate interaction that could exacerbate diseases when taken... |
DB00069 | DB00099 | 367 | 440 | [
"DDInter946",
"DDInter735"
] | Interferon alfacon-1 | Filgrastim | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the seq... | Moderate | 1 | [
[
[
367,
24,
440
]
],
[
[
367,
24,
1480
],
[
1480,
63,
440
]
],
[
[
367,
25,
1101
],
[
1101,
63,
440
]
],
[
[
367,
63,
1451
],
[
1451,
... | [
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Filgrastim"
]
],
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixazomi... | Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib and Ixazomib may cause a moderate interaction that could exacerbate diseases when taken with Filgrastim
Interferon alfacon-1 may lead to a major life threatening interaction when taken with Bexarotene and Bexar... |
DB00762 | DB14975 | 613 | 988 | [
"DDInter973",
"DDInter1949"
] | Irinotecan | Voxelotor | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Voxelotor is a novel hemoglobin S polymerization inhibitor for the treatment of sickle cell disease. This is a genetically inherited condition most prevalent in the Middle East, Africa, and certain parts of India. Sickle cell disease can lead to excruciating pain, stroke, infection, and various other complications aris... | Moderate | 1 | [
[
[
613,
24,
988
]
],
[
[
613,
24,
466
],
[
466,
23,
988
]
],
[
[
613,
24,
629
],
[
629,
24,
988
]
],
[
[
613,
25,
676
],
[
676,
63,... | [
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Voxelotor"
]
],
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
... | Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Voxelotor
Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Siroli... |
DB00250 | DB00750 | 10 | 490 | [
"DDInter475",
"DDInter1518"
] | Dapsone | Prilocaine | A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of m... | A local anesthetic that is similar pharmacologically to lidocaine. Currently, it is used most often for infiltration anesthesia in dentistry. (From AMA Drug Evaluations Annual, 1992, p165) | Major | 2 | [
[
[
10,
25,
490
]
],
[
[
10,
21,
28722
],
[
28722,
60,
490
]
],
[
[
10,
24,
1520
],
[
1520,
64,
490
]
],
[
[
10,
25,
1455
],
[
1455,
... | [
[
[
"Dapsone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prilocaine"
]
],
[
[
"Dapsone",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused by {v} (Compound)",
... | Dapsone (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Prilocaine (Compound)
Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Primaquine and Primaquine may lead to a major life threatening interaction when taken with Prilocaine
Dapsone may lead to a m... |
DB01218 | DB09065 | 1,493 | 760 | [
"DDInter852",
"DDInter424"
] | Halofantrine | Cobicistat | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Major | 2 | [
[
[
1493,
25,
760
]
],
[
[
1493,
62,
479
],
[
479,
23,
760
]
],
[
[
1493,
64,
1230
],
[
1230,
23,
760
]
],
[
[
1493,
63,
1101
],
[
1101,
... | [
[
[
"Halofantrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobicistat"
]
],
[
[
"Halofantrine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Donepezil"
],
[
"Donepezil... | Halofantrine may cause a minor interaction that can limit clinical effects when taken with Donepezil and Donepezil may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Halofantrine may lead to a major life threatening interaction when taken with Citalopram and Citalopram may cause a ... |
DB00468 | DB01041 | 1,424 | 770 | [
"DDInter1557",
"DDInter1789"
] | Quinine | Thalidomide | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
1424,
24,
770
]
],
[
[
1424,
6,
6365
],
[
6365,
45,
770
]
],
[
[
1424,
18,
3106
],
[
3106,
57,
770
]
],
[
[
1424,
21,
28789
],
[
28789... | [
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Quinine",
"{u} (Compound) binds {v} (Gene)",
"CYP2E1"
],
[
"CYP2E1",
"{u} (Gene) is bound by {v} (Compound)",
... | Quinine (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Thalidomide (Compound)
Quinine (Compound) downregulates DNAJA3 (Gene) and DNAJA3 (Gene) is downregulated by Thalidomide (Compound)
Quinine (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Thali... |
DB08885 | DB14443 | 363 | 987 | [
"DDInter33",
"DDInter1931"
] | Aflibercept | Vibrio cholerae CVD 103-HgR strain live antigen | Aflibercept is a recombinant protein composed of the binding domains of two human vascular endothelial growth factor (VEGF) receptors, VEGFR1 and VEGFR2, fused with the Fc region of human immunoglobulin gamma 1 (IgG1). Structurally, Aflibercept is a dimeric glycoprotein with a protein molecular weight of 96.9 kilo Dalt... | _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against _Vibrio cholerae_ serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by _Vibrio cholerae_, which is gram-negative bacteria. Two serogroups of _V. cholerae_, O1 and O139, ... | Moderate | 1 | [
[
[
363,
24,
987
]
],
[
[
363,
63,
259
],
[
259,
24,
987
]
],
[
[
363,
24,
1362
],
[
1362,
24,
987
]
],
[
[
363,
64,
581
],
[
581,
2... | [
[
[
"Aflibercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strain live antigen"
]
],
[
[
"Aflibercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {... | Aflibercept may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen
Aflibercept may cause a moderate interaction that could exacerbate disease... |
DB00496 | DB06589 | 194 | 1,250 | [
"DDInter480",
"DDInter1400"
] | Darifenacin | Pazopanib | Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence. Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it should not be used in people with urinary retention. It is unknown if M3 receptor ... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
194,
24,
1250
]
],
[
[
194,
6,
12523
],
[
12523,
45,
1250
]
],
[
[
194,
7,
5178
],
[
5178,
46,
1250
]
],
[
[
194,
18,
5266
],
[
5266,
... | [
[
[
"Darifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Darifenacin",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)"... | Darifenacin (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Pazopanib (Compound)
Darifenacin (Compound) upregulates XBP1 (Gene) and XBP1 (Gene) is upregulated by Pazopanib (Compound)
Darifenacin (Compound) downregulates SMC1A (Gene) and SMC1A (Gene) is downregulated by Pazopanib (Compound)
Darifenacin (Com... |
DB00328 | DB00687 | 831 | 870 | [
"DDInter921",
"DDInter747"
] | Indomethacin | Fludrocortisone | Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlor... | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Moderate | 1 | [
[
[
831,
24,
870
]
],
[
[
831,
24,
1220
],
[
1220,
40,
870
]
],
[
[
831,
21,
28835
],
[
28835,
60,
870
]
],
[
[
831,
23,
115
],
[
115,
... | [
[
[
"Indomethacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
]
],
[
[
"Indomethacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
... | Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Fludrocortisone (Compound)
Indomethacin (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Fludrocortisone (Compound)
Indomethacin m... |
DB00387 | DB00572 | 1,386 | 85 | [
"DDInter1528",
"DDInter136"
] | Procyclidine | Atropine | A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism. | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Moderate | 1 | [
[
[
1386,
24,
85
]
],
[
[
1386,
24,
19
],
[
19,
24,
85
]
],
[
[
1386,
63,
1089
],
[
1089,
24,
85
]
],
[
[
1386,
6,
4304
],
[
4304,
4... | [
[
[
"Procyclidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atropine"
]
],
[
[
"Procyclidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
[... | Procyclidine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Atropine
Procyclidine may cause a moderate interaction that could exacerbate diseases when taken with Ipratropium and I... |
DB00530 | DB01211 | 1,195 | 609 | [
"DDInter667",
"DDInter393"
] | Erlotinib | Clarithromycin | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
1195,
24,
609
]
],
[
[
1195,
6,
4973
],
[
4973,
45,
609
]
],
[
[
1195,
7,
4333
],
[
4333,
46,
609
]
],
[
[
1195,
18,
4360
],
[
4360,
... | [
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Erlotinib",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",... | Erlotinib (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clarithromycin (Compound)
Erlotinib (Compound) upregulates MEF2C (Gene) and MEF2C (Gene) is upregulated by Clarithromycin (Compound)
Erlotinib (Compound) downregulates TIMM9 (Gene) and TIMM9 (Gene) is downregulated by Clarithromycin (Compound)
Erlotin... |
DB00054 | DB00991 | 1,432 | 97 | [
"DDInter6",
"DDInter1358"
] | Abciximab | Oxaprozin | Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (αv... | Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. | Moderate | 1 | [
[
[
1432,
24,
97
]
],
[
[
1432,
24,
1274
],
[
1274,
24,
97
]
],
[
[
1432,
24,
998
],
[
998,
1,
97
]
],
[
[
1432,
25,
936
],
[
936,
6... | [
[
[
"Abciximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaprozin"
]
],
[
[
"Abciximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
],
[
... | Abciximab may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Oxaprozin
Abciximab may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutazone and P... |
DB00371 | DB00372 | 1,050 | 999 | [
"DDInter1154",
"DDInter1793"
] | Meprobamate | Thiethylperazine | A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (... | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Moderate | 1 | [
[
[
1050,
24,
999
]
],
[
[
1050,
24,
1614
],
[
1614,
63,
999
]
],
[
[
1050,
63,
1242
],
[
1242,
24,
999
]
],
[
[
1050,
64,
475
],
[
475,
... | [
[
[
"Meprobamate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thiethylperazine"
]
],
[
[
"Meprobamate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
],
... | Meprobamate may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine
Meprobamate may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Ce... |
DB01579 | DB06704 | 341 | 247 | [
"DDInter1439",
"DDInter952"
] | Phendimetrazine | Iobenguane (I-131) | Phendimetrazine is a weight loss medication. Phendimetrazine is chemically related to amphetamines and is a Schedule III drug under the Convention on Psychotropic Substances and in the US since 1970. | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Major | 2 | [
[
[
341,
37,
247
]
],
[
[
341,
6,
7390
],
[
7390,
45,
247
]
],
[
[
341,
21,
28921
],
[
28921,
60,
247
]
],
[
[
341,
63,
820
],
[
820,
... | [
[
[
"Phendimetrazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v}",
"Iobenguane"
]
],
[
[
"Phendimetrazine",
"{u} (Compound) binds {v} (Gene)",
... | Phendimetrazine may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane and Phendimetrazine may lead to a major life threatening interaction when taken with Iobenguane
Phendimetrazine (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Iobenguane (Compound)
Phendimetrazine (C... |
DB01177 | DB09498 | 77 | 810 | [
"DDInter904",
"DDInter1715"
] | Idarubicin | Strontium chloride Sr-89 | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Moderate | 1 | [
[
[
77,
24,
810
]
],
[
[
77,
63,
552
],
[
552,
24,
810
]
],
[
[
77,
24,
1532
],
[
1532,
24,
810
]
],
[
[
77,
24,
1619
],
[
1619,
63,... | [
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Strontium chloride Sr-89"
]
],
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carmustine"
... | Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Carmustine and Carmustine may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89
Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Ifosfam... |
DB00641 | DB01110 | 467 | 86 | [
"DDInter1675",
"DDInter1209"
] | Simvastatin | Miconazole | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Moderate | 1 | [
[
[
467,
24,
86
]
],
[
[
467,
6,
10215
],
[
10215,
45,
86
]
],
[
[
467,
7,
5415
],
[
5415,
46,
86
]
],
[
[
467,
18,
20102
],
[
20102,
... | [
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miconazole"
]
],
[
[
"Simvastatin",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compoun... | Simvastatin (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Miconazole (Compound)
Simvastatin (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Miconazole (Compound)
Simvastatin (Compound) downregulates FAM57A (Gene) and FAM57A (Gene) is downregulated by Miconazole (Compound)
Simva... |
DB00491 | DB00777 | 127 | 146 | [
"DDInter1217",
"DDInter1537"
] | Miglitol | Propiomazine | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Struct... | Moderate | 1 | [
[
[
127,
24,
146
]
],
[
[
127,
63,
508
],
[
508,
1,
146
]
],
[
[
127,
24,
401
],
[
401,
63,
146
]
],
[
[
127,
24,
1178
],
[
1178,
1,... | [
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propiomazine"
]
],
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promazine"
],
[
... | Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine (Compound) resembles Propiomazine (Compound)
Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could... |
DB00581 | DB01591 | 355 | 667 | [
"DDInter1018",
"DDInter1696"
] | Lactulose | Solifenacin | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004. | Moderate | 1 | [
[
[
355,
24,
667
]
],
[
[
355,
21,
28722
],
[
28722,
60,
667
]
],
[
[
355,
24,
774
],
[
774,
63,
667
]
],
[
[
355,
24,
392
],
[
392,
... | [
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Solifenacin"
]
],
[
[
"Lactulose",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused by {... | Lactulose (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Solifenacin (Compound)
Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Degarelix and Degarelix may cause a moderate interaction that could exacerbate diseases when taken with Solifenacin
Lact... |
DB00294 | DB06655 | 1,336 | 5 | [
"DDInter701",
"DDInter1077"
] | Etonogestrel | Liraglutide | Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel. The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001. | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Moderate | 1 | [
[
[
1336,
24,
5
]
],
[
[
1336,
25,
353
],
[
353,
23,
5
]
],
[
[
1336,
63,
245
],
[
245,
24,
5
]
],
[
[
1336,
40,
1197
],
[
1197,
24,... | [
[
[
"Etonogestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liraglutide"
]
],
[
[
"Etonogestrel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Griseofulvin"
],
[
"Gri... | Etonogestrel may lead to a major life threatening interaction when taken with Griseofulvin and Griseofulvin may cause a minor interaction that can limit clinical effects when taken with Liraglutide
Etonogestrel may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride m... |
DB00331 | DB00938 | 1,645 | 455 | [
"DDInter1164",
"DDInter1635"
] | Metformin | Salmeterol | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Moderate | 1 | [
[
[
1645,
24,
455
]
],
[
[
1645,
24,
688
],
[
688,
63,
455
]
],
[
[
1645,
18,
5833
],
[
5833,
46,
455
]
],
[
[
1645,
21,
29095
],
[
29095,... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
],
[
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol
Metformin (Compound) downregulates ACAT2 (Gene) and ACAT2 (Gene) is upregulated by Salmeterol (Compound)
Metformi... |
DB00726 | DB11186 | 1,164 | 1,609 | [
"DDInter1876",
"DDInter1427"
] | Trimipramine | Pentoxyverine | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
1164,
24,
1609
]
],
[
[
1164,
1,
508
],
[
508,
24,
1609
]
],
[
[
1164,
35,
104
],
[
104,
24,
1609
]
],
[
[
1164,
63,
999
],
[
999,
... | [
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Trimipramine",
"{u} (Compound) resembles {v} (Compound)",
"Promazine"
],
[
"Promazine",
"{u} may cause a mo... | Trimipramine (Compound) resembles Promazine (Compound) and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Trimipramine (Compound) resembles Methdilazine (Compound) and Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Me... |
DB01409 | DB11160 | 1,415 | 337 | [
"DDInter1815",
"DDInter1459"
] | Tiotropium | Phenyltoloxamine | Tiotropium is a long-acting, antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma.[A180163,L7084,L7087,L7090,L7093] Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and bronchodilation.[A180163,L7084,L... | Phenyltoloxamine is an antihistamine drug with sedative and analgesic effects. It is a H1 receptor blocker and a member of the ethanolamine class of antihistaminergic drugs. It is available in combination products that also contain other analgesics and antitussives such as acetaminophen. Phenyltoloxamine citrate is the... | Moderate | 1 | [
[
[
1415,
24,
337
]
],
[
[
1415,
63,
820
],
[
820,
24,
337
]
],
[
[
1415,
24,
1511
],
[
1511,
24,
337
]
],
[
[
1415,
35,
1429
],
[
1429,
... | [
[
[
"Tiotropium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyltoloxamine"
]
],
[
[
"Tiotropium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
],
... | Tiotropium may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Phenyltoloxamine
Tiotropium may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate a... |
DB00450 | DB11901 | 78 | 913 | [
"DDInter603",
"DDInter107"
] | Droperidol | Apalutamide | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Major | 2 | [
[
[
78,
25,
913
]
],
[
[
78,
23,
112
],
[
112,
23,
913
]
],
[
[
78,
64,
600
],
[
600,
24,
913
]
],
[
[
78,
24,
28
],
[
28,
24,
... | [
[
[
"Droperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apalutamide"
]
],
[
[
"Droperidol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronid... | Droperidol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Droperidol may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may c... |
DB01030 | DB01181 | 869 | 1,532 | [
"DDInter1835",
"DDInter906"
] | Topotecan | Ifosfamide | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
869,
24,
1532
]
],
[
[
869,
6,
8374
],
[
8374,
45,
1532
]
],
[
[
869,
21,
29209
],
[
29209,
60,
1532
]
],
[
[
869,
62,
1299
],
[
1299,... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Topotecan",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Topotecan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ifosfamide (Compound)
Topotecan (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Ifosfamide (Compound)
Topotecan may cause a minor interaction that can limit clinical effects when taken with Trovafloxacin and Trovaflo... |
DB06674 | DB14004 | 908 | 398 | [
"DDInter837",
"DDInter1806"
] | Golimumab | Tildrakizumab | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Tildrakizumab is a high-affinity, humanized, IgG1 κ antibody targeting interleukin 23 p19 that shows promise in the evolution of treatment strategy in chronic plaque psoriasis . The Food and Drug Administration (FDA) approved ILUMYA (tildrakizumab-asmn) for the treatment of adults with moderate-to-severe plaque psorias... | Major | 2 | [
[
[
908,
25,
398
]
],
[
[
908,
23,
1114
],
[
1114,
23,
398
]
],
[
[
908,
62,
1461
],
[
1461,
23,
398
]
],
[
[
908,
63,
58
],
[
58,
2... | [
[
[
"Golimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tildrakizumab"
]
],
[
[
"Golimumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc sulfate"
],
[
"Zinc sulf... | Golimumab may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Tildrakizumab
Golimumab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin ... |
DB08880 | DB09389 | 1,510 | 517 | [
"DDInter1771",
"DDInter1315"
] | Teriflunomide | Norgestrel | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Norgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantiomer ([levonorgestrel]) is biologically active. | Moderate | 1 | [
[
[
1510,
24,
517
]
],
[
[
1510,
64,
1130
],
[
1130,
23,
517
]
],
[
[
1510,
25,
159
],
[
159,
63,
517
]
],
[
[
1510,
64,
581
],
[
581,
... | [
[
[
"Teriflunomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norgestrel"
]
],
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pioglitazone"
],
[
"Pi... | Teriflunomide may lead to a major life threatening interaction when taken with Pioglitazone and Pioglitazone may cause a minor interaction that can limit clinical effects when taken with Norgestrel
Teriflunomide may lead to a major life threatening interaction when taken with Larotrectinib and Larotrectinib may cause a... |
DB00348 | DB00872 | 254 | 1,080 | [
"DDInter1300",
"DDInter438"
] | Nitisinone | Conivaptan | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Moderate | 1 | [
[
[
254,
24,
1080
]
],
[
[
254,
24,
165
],
[
165,
40,
1080
]
],
[
[
254,
21,
28646
],
[
28646,
60,
1080
]
],
[
[
254,
24,
126
],
[
126,
... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Conivaptan"
]
],
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolvaptan"
],
[
... | Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Tolvaptan and Tolvaptan (Compound) resembles Conivaptan (Compound)
Nitisinone (Compound) causes Unspecified disorder of skin and subcutaneous tissue (Side Effect) and Unspecified disorder of skin and subcutaneous tissue (Side Eff... |
DB00653 | DB00762 | 544 | 613 | [
"DDInter1120",
"DDInter973"
] | Magnesium sulfate | Irinotecan | A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions... | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Moderate | 1 | [
[
[
544,
24,
613
]
],
[
[
544,
21,
28936
],
[
28936,
60,
613
]
],
[
[
544,
63,
1467
],
[
1467,
23,
613
]
],
[
[
544,
24,
945
],
[
945,
... | [
[
[
"Magnesium sulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Irinotecan"
]
],
[
[
"Magnesium sulfate",
"{u} (Compound) causes {v} (Side Effect)",
"Hyperhidrosis"
],
[
"Hyperhidrosis",
"{u}... | Magnesium sulfate (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Irinotecan (Compound)
Magnesium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Enoxacin and Enoxacin may cause a minor interaction that can limit clinical effects when ta... |
DB06448 | DB09038 | 171 | 1,450 | [
"DDInter1087",
"DDInter636"
] | Lonafarnib | Empagliflozin | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
171,
24,
1450
]
],
[
[
171,
24,
659
],
[
659,
63,
1450
]
],
[
[
171,
64,
1486
],
[
1486,
24,
1450
]
],
[
[
171,
63,
870
],
[
870,
... | [
[
[
"Lonafarnib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Lonafarnib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
],
[... | Lonafarnib may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Lonafarnib may lead to a major life threatening interaction when taken with Methylprednisolone and Methylpred... |
DB00889 | DB01224 | 1,133 | 623 | [
"DDInter840",
"DDInter1553"
] | Granisetron | Quetiapine | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Moderate | 1 | [
[
[
1133,
24,
623
]
],
[
[
1133,
64,
827
],
[
827,
1,
623
]
],
[
[
1133,
25,
851
],
[
851,
1,
623
]
],
[
[
1133,
63,
252
],
[
252,
1... | [
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quetiapine"
]
],
[
[
"Granisetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trazodone"
],
[
"Trazodone... | Granisetron may lead to a major life threatening interaction when taken with Trazodone and Trazodone (Compound) resembles Quetiapine (Compound)
Granisetron may lead to a major life threatening interaction when taken with Nefazodone and Nefazodone (Compound) resembles Quetiapine (Compound)
Granisetron may cause a modera... |
DB00877 | DB06717 | 629 | 875 | [
"DDInter1678",
"DDInter778"
] | Sirolimus | Fosaprepitant | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment. | Moderate | 1 | [
[
[
629,
24,
875
]
],
[
[
629,
63,
723
],
[
723,
1,
875
]
],
[
[
629,
21,
29180
],
[
29180,
60,
875
]
],
[
[
629,
24,
222
],
[
222,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosaprepitant"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[
... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant (Compound) resembles Fosaprepitant (Compound)
Sirolimus (Compound) causes Abdominal distension (Side Effect) and Abdominal distension (Side Effect) is caused by Fosaprepitant (Compound)
Sirolimus may caus... |
DB00712 | DB01105 | 1,274 | 222 | [
"DDInter763",
"DDInter1665"
] | Flurbiprofen | Sibutramine | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
1274,
24,
222
]
],
[
[
1274,
18,
4930
],
[
4930,
57,
222
]
],
[
[
1274,
21,
29215
],
[
29215,
60,
222
]
],
[
[
1274,
63,
839
],
[
839,... | [
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Flurbiprofen",
"{u} (Compound) downregulates {v} (Gene)",
"DLD"
],
[
"DLD",
"{u} (Gene) is downregulated by {... | Flurbiprofen (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Sibutramine (Compound)
Flurbiprofen (Compound) causes Ecchymosis (Side Effect) and Ecchymosis (Side Effect) is caused by Sibutramine (Compound)
Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00443 | DB01122 | 251 | 158 | [
"DDInter195",
"DDInter61"
] | Betamethasone | Ambenonium | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Ambenonium is a cholinesterase inhibitor. It is used in the management of myasthenia gravis. | Moderate | 1 | [
[
[
251,
24,
158
]
],
[
[
251,
40,
870
],
[
870,
24,
158
]
],
[
[
251,
1,
1573
],
[
1573,
24,
158
]
],
[
[
251,
25,
1011
],
[
1011,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ambenonium"
]
],
[
[
"Betamethasone",
"{u} (Compound) resembles {v} (Compound)",
"Fludrocortisone"
],
[
"Fludrocortisone",
"{u} may... | Betamethasone (Compound) resembles Fludrocortisone (Compound) and Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Ambenonium
Betamethasone (Compound) resembles Prednisone (Compound) and Prednisone may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00488 | DB01165 | 196 | 1,539 | [
"DDInter57",
"DDInter1325"
] | Altretamine | Ofloxacin | An alkylating agent proposed as an antineoplastic. It also acts as a chemosterilant for male houseflies and other insects. | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Minor | 0 | [
[
[
196,
23,
1539
]
],
[
[
196,
62,
1467
],
[
1467,
1,
1539
]
],
[
[
196,
23,
945
],
[
945,
40,
1539
]
],
[
[
196,
23,
739
],
[
739,
... | [
[
[
"Altretamine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ofloxacin"
]
],
[
[
"Altretamine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Enoxacin"
],
[
"... | Altretamine may cause a minor interaction that can limit clinical effects when taken with Enoxacin and Enoxacin (Compound) resembles Ofloxacin (Compound)
Altretamine may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Ofloxacin (Compound)
Altr... |
DB01216 | DB14723 | 284 | 159 | [
"DDInter736",
"DDInter1026"
] | Finasteride | Larotrectinib | Finasteride is a synthetic 4-azasteroid compound and specific inhibitor of steroid Type II 5α-reductase, which is an intracellular enzyme that converts the androgen testosterone into 5α-dihydrotestosterone (DHT). It works in a similar fashion as [dutasteride], which is another 5-alpha-reductase inhibitor, by exerting a... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
284,
24,
159
]
],
[
[
284,
24,
1375
],
[
1375,
24,
159
]
],
[
[
284,
40,
1260
],
[
1260,
24,
159
]
],
[
[
284,
63,
529
],
[
529,
... | [
[
[
"Finasteride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Finasteride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
],
... | Finasteride may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin and Lefamulin may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib
Finasteride (Compound) resembles Dutasteride (Compound) and Dutasteride may cause a moderate interaction that ... |
DB00197 | DB09564 | 1,324 | 1,296 | [
"DDInter1881",
"DDInter930"
] | Troglitazone | Insulin degludec | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
1324,
24,
1296
]
],
[
[
1324,
23,
1103
],
[
1103,
23,
1296
]
],
[
[
1324,
62,
333
],
[
333,
23,
1296
]
],
[
[
1324,
24,
659
],
[
659,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Troglitazone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
],
... | Troglitazone may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Insulin degludec
Troglitazone may cause a minor interaction that can limit clinical effects when taken with Lipoic acid and L... |
DB09280 | DB11837 | 1,604 | 1,297 | [
"DDInter1101",
"DDInter1351"
] | Lumacaftor | Osilodrostat | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Major | 2 | [
[
[
1604,
25,
1297
]
],
[
[
1604,
64,
1135
],
[
1135,
23,
1297
]
],
[
[
1604,
25,
466
],
[
466,
62,
1297
]
],
[
[
1604,
64,
623
],
[
623,
... | [
[
[
"Lumacaftor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osilodrostat"
]
],
[
[
"Lumacaftor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} m... | Lumacaftor may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Lumacaftor may lead to a major life threatening interaction when taken with Darolutamide and Darolutamide may cause a minor inter... |
DB08816 | DB08896 | 578 | 292 | [
"DDInter1802",
"DDInter1576"
] | Ticagrelor | Regorafenib | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Major | 2 | [
[
[
578,
25,
292
]
],
[
[
578,
63,
79
],
[
79,
1,
292
]
],
[
[
578,
6,
8374
],
[
8374,
45,
292
]
],
[
[
578,
21,
29122
],
[
29122,
6... | [
[
[
"Ticagrelor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Regorafenib"
]
],
[
[
"Ticagrelor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sorafenib"
],
[
"Sorafenib"... | Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib (Compound) resembles Regorafenib (Compound)
Ticagrelor (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Regorafenib (Compound)
Ticagrelor (Compound) causes Mediastinal disorder (Side Effect) an... |
DB00215 | DB00757 | 1,230 | 1,166 | [
"DDInter388",
"DDInter581"
] | Citalopram | Dolasetron | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Major | 2 | [
[
[
1230,
25,
1166
]
],
[
[
1230,
6,
12523
],
[
12523,
45,
1166
]
],
[
[
1230,
21,
28726
],
[
28726,
60,
1166
]
],
[
[
1230,
25,
752
],
[
... | [
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dolasetron"
]
],
[
[
"Citalopram",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Dolaset... | Citalopram (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Dolasetron (Compound)
Citalopram (Compound) causes Oliguria (Side Effect) and Oliguria (Side Effect) is caused by Dolasetron (Compound)
Citalopram may lead to a major life threatening interaction when taken with Cimetidine and Cimetidine may cause ... |
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