drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01024 | DB10343 | 1,096 | 962 | [
"DDInter1252",
"DDInter160"
] | Mycophenolic acid | Bacillus calmette-guerin substrain tice live antigen | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Bacillus calmette-guerin substrain tice live antigen is a vaccine containing attenuated live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of *Mycobacterium bovis* for percutaneous use. It is administered to prevent the development of tuberculosis. | Major | 2 | [
[
[
1096,
25,
962
]
],
[
[
1096,
64,
1057
],
[
1057,
25,
962
]
],
[
[
1096,
24,
270
],
[
270,
64,
962
]
],
[
[
1096,
25,
976
],
[
976,
... | [
[
[
"Mycophenolic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bacillus calmette-guerin substrain tice live antigen"
]
],
[
[
"Mycophenolic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"E... | Mycophenolic acid may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Bacillus calmette-guerin substrain tice live antigen
Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00197 | DB09100 | 1,324 | 320 | [
"DDInter1881",
"DDInter1799"
] | Troglitazone | Thyroid, porcine | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Thyroid extract is dried and powdered thyroid glands from pigs containing tiiodothyronine (T3) and thyroxine (T4) used to supplement low or absent thyroid activity.[A190831,L11755] Thyroid extract has been described in literature to treat hypothyroidism since 1891 but its use dates back as far as the 6th century. Thyro... | Moderate | 1 | [
[
[
1324,
24,
320
]
],
[
[
1324,
24,
417
],
[
417,
23,
320
]
],
[
[
1324,
24,
1130
],
[
1130,
24,
320
]
],
[
[
1324,
63,
73
],
[
73,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thyroid, porcine"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sucralfate"
]... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Sucralfate and Sucralfate may cause a minor interaction that can limit clinical effects when taken with Thyroid, porcine
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Pioglitazone ... |
DB00241 | DB06589 | 288 | 1,250 | [
"DDInter257",
"DDInter1400"
] | Butalbital | Pazopanib | Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervou... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
288,
24,
1250
]
],
[
[
288,
24,
112
],
[
112,
23,
1250
]
],
[
[
288,
24,
1135
],
[
1135,
62,
1250
]
],
[
[
288,
24,
1151
],
[
1151,
... | [
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pazopanib
Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Nalo... |
DB00041 | DB06643 | 1,648 | 1,136 | [
"DDInter38",
"DDInter500"
] | Aldesleukin | Denosumab | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL inhibitor approved to prevent osteoclast-mediated bone loss.... | Moderate | 1 | [
[
[
1648,
24,
1136
]
],
[
[
1648,
24,
1555
],
[
1555,
24,
1136
]
],
[
[
1648,
25,
1377
],
[
1377,
24,
1136
]
],
[
[
1648,
64,
1451
],
[
14... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Denosumab"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin"
],
[
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Denosumab
Aldesleukin may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may c... |
DB01284 | DB06335 | 1,042 | 761 | [
"DDInter1782",
"DDInter1646"
] | Tetracosactide | Saxagliptin | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
1042,
24,
761
]
],
[
[
1042,
63,
1577
],
[
1577,
24,
761
]
],
[
[
1042,
24,
178
],
[
178,
24,
761
]
],
[
[
1042,
24,
1296
],
[
1296,
... | [
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroflumethiazide... | Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Hydroflumethiazide and Hydroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin
Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken w... |
DB01048 | DB09065 | 764 | 760 | [
"DDInter1",
"DDInter424"
] | Abacavir | Cobicistat | Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. Chemically, it is a synthetic carbocyclic nucleoside and is the enantiomer with 1S, 4R absolute configuration on the cyclopentene ring. In vivo, abacavir sulfate dissociates to its free base, abacavir. | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
764,
24,
760
]
],
[
[
764,
24,
384
],
[
384,
24,
760
]
],
[
[
764,
24,
1618
],
[
1618,
25,
760
]
],
[
[
764,
24,
384
],
[
384,
6... | [
[
[
"Abacavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Abacavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
[
... | Abacavir may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat
Abacavir may cause a moderate interaction that could exacerbate diseases when taken with Cabozantinib and Cabozant... |
DB00675 | DB05239 | 888 | 866 | [
"DDInter1744",
"DDInter425"
] | Tamoxifen | Cobimetinib | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Moderate | 1 | [
[
[
888,
24,
866
]
],
[
[
888,
24,
214
],
[
214,
63,
866
]
],
[
[
888,
63,
1051
],
[
1051,
24,
866
]
],
[
[
888,
25,
33
],
[
33,
24,... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobimetinib"
]
],
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
],
[
... | Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Cobimetinib
Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Aminoglutethimide ... |
DB00556 | DB09080 | 1,262 | 144 | [
"DDInter1429",
"DDInter1331"
] | Perflutren | Olodaterol | Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultras... | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
1262,
24,
144
]
],
[
[
1262,
25,
1011
],
[
1011,
24,
144
]
],
[
[
1262,
64,
11
],
[
11,
24,
144
]
],
[
[
1262,
24,
543
],
[
543,
... | [
[
[
"Perflutren",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Perflutren",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
],
[
"Fingolimod... | Perflutren may lead to a major life threatening interaction when taken with Fingolimod and Fingolimod may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Perflutren may lead to a major life threatening interaction when taken with Toremifene and Toremifene may cause a moderate inte... |
DB09049 | DB11730 | 1,135 | 351 | [
"DDInter1261",
"DDInter1588"
] | Naloxegol | Ribociclib | Naloxegol, for "PEGylated naloxol" is a peripherally-selective opioid antagonist developed by AstraZeneca. It was approved by the FDA in September 2014 and is indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non‑cancer pain. The advantage of naloxegol over the opioid antag... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
1135,
25,
351
]
],
[
[
1135,
25,
283
],
[
283,
62,
351
]
],
[
[
1135,
63,
288
],
[
288,
24,
351
]
],
[
[
1135,
64,
597
],
[
597,
... | [
[
[
"Naloxegol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Naloxegol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
],
[
"Fedratinib",
"{u} may... | Naloxegol may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Naloxegol may cause a moderate interaction that could exacerbate diseases when taken with Butalbital and Butalbital may cause a mo... |
DB00283 | DB00327 | 701 | 421 | [
"DDInter395",
"DDInter890"
] | Clemastine | Hydromorphone | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of [morphine] that has been available clinically since 1920. Structurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 a... | Moderate | 1 | [
[
[
701,
24,
421
]
],
[
[
701,
24,
828
],
[
828,
40,
421
]
],
[
[
701,
24,
475
],
[
475,
25,
421
]
],
[
[
701,
24,
993
],
[
993,
1,
... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydromorphone"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxycodone"
],
[
... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone and Oxycodone (Compound) resembles Hydromorphone (Compound)
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may lead to a major life threatening interacti... |
DB06603 | DB14881 | 39 | 180 | [
"DDInter1387",
"DDInter1329"
] | Panobinostat | Oliceridine | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Major | 2 | [
[
[
39,
25,
180
]
],
[
[
39,
62,
112
],
[
112,
23,
180
]
],
[
[
39,
64,
401
],
[
401,
24,
180
]
],
[
[
39,
24,
1094
],
[
1094,
24,
... | [
[
[
"Panobinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Oliceridine"
]
],
[
[
"Panobinostat",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metr... | Panobinostat may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Oliceridine
Panobinostat may lead to a major life threatening interaction when taken with Promethazine and Promethazine... |
DB01610 | DB11703 | 248 | 405 | [
"DDInter1912",
"DDInter9"
] | Valganciclovir | Acalabrutinib | Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases. | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Moderate | 1 | [
[
[
248,
24,
405
]
],
[
[
248,
63,
1101
],
[
1101,
24,
405
]
],
[
[
248,
24,
951
],
[
951,
24,
405
]
],
[
[
248,
24,
1619
],
[
1619,
... | [
[
[
"Valganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Valganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
... | Valganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Valganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Palbocicli... |
DB00564 | DB09241 | 1,236 | 1,629 | [
"DDInter293",
"DDInter1186"
] | Carbamazepine | Methylene blue | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Major | 2 | [
[
[
1236,
25,
1629
]
],
[
[
1236,
24,
1311
],
[
1311,
24,
1629
]
],
[
[
1236,
1,
1405
],
[
1405,
25,
1629
]
],
[
[
1236,
40,
1164
],
[
116... | [
[
[
"Carbamazepine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylene blue"
]
],
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
],
[
... | Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Carbamazepine (Compound) resembles Cyclobenzaprine (Compound) and Cyclobenzaprine may lead to a m... |
DB00857 | DB01045 | 1,387 | 463 | [
"DDInter1768",
"DDInter1590"
] | Terbinafine | Rifampicin | Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epox... | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Minor | 0 | [
[
[
1387,
23,
463
]
],
[
[
1387,
6,
7950
],
[
7950,
45,
463
]
],
[
[
1387,
24,
1264
],
[
1264,
62,
463
]
],
[
[
1387,
63,
267
],
[
267,
... | [
[
[
"Terbinafine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Rifampicin"
]
],
[
[
"Terbinafine",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",... | Terbinafine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Rifampicin (Compound)
Terbinafine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a minor interaction that can limit clinical effects when taken with Rifampicin
Terbinafine may cause a ... |
DB11901 | DB11979 | 913 | 1,320 | [
"DDInter107",
"DDInter625"
] | Apalutamide | Elagolix | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements. It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Resi... | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
913,
24,
1320
]
],
[
[
913,
64,
168
],
[
168,
23,
1320
]
],
[
[
913,
62,
608
],
[
608,
23,
1320
]
],
[
[
913,
64,
1297
],
[
1297,
... | [
[
[
"Apalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Apalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bortezomib"
],
[
"Bortezomib... | Apalutamide may lead to a major life threatening interaction when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Elagolix
Apalutamide may cause a minor interaction that can limit clinical effects when taken with Lidocaine and Lidocaine may cause a mino... |
DB01232 | DB06699 | 1,327 | 774 | [
"DDInter1640",
"DDInter493"
] | Saquinavir | Degarelix | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Major | 2 | [
[
[
1327,
25,
774
]
],
[
[
1327,
64,
521
],
[
521,
1,
774
]
],
[
[
1327,
21,
29232
],
[
29232,
60,
774
]
],
[
[
1327,
62,
112
],
[
112,
... | [
[
[
"Saquinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Degarelix"
]
],
[
[
"Saquinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Goserelin"
],
[
"Goserelin",
"{u} (Com... | Saquinavir may lead to a major life threatening interaction when taken with Goserelin and Goserelin (Compound) resembles Degarelix (Compound)
Saquinavir (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Degarelix (Compound)
Saquinavir may cause a minor interaction that can limit clinica... |
DB01176 | DB01238 | 537 | 673 | [
"DDInter453",
"DDInter118"
] | Cyclizine | Aripiprazole | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Moderate | 1 | [
[
[
537,
24,
673
]
],
[
[
537,
63,
851
],
[
851,
1,
673
]
],
[
[
537,
63,
827
],
[
827,
40,
673
]
],
[
[
537,
1,
1321
],
[
1321,
40,... | [
[
[
"Cyclizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aripiprazole"
]
],
[
[
"Cyclizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nefazodone"
],
[
... | Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Nefazodone and Nefazodone (Compound) resembles Aripiprazole (Compound)
Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Trazodone and Trazodone (Compound) resembles Aripiprazole (Compound)
... |
DB11796 | DB12015 | 1,612 | 1,033 | [
"DDInter786",
"DDInter53"
] | Fostemsavir | Alpelisib | Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor. It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir prevents the first step in the... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
1612,
24,
1033
]
],
[
[
1612,
63,
738
],
[
738,
24,
1033
]
],
[
[
1612,
64,
985
],
[
985,
24,
1033
]
],
[
[
1612,
62,
353
],
[
353,
... | [
[
[
"Fostemsavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Fostemsavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
],
[
... | Fostemsavir may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Fostemsavir may lead to a major life threatening interaction when taken with Osimertinib and Osimertinib may cause... |
DB00924 | DB01409 | 1,405 | 1,415 | [
"DDInter454",
"DDInter1815"
] | Cyclobenzaprine | Tiotropium | Cyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961 and has been available for human use since 1977. It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from [Amitriptyline] by only a single double bond.[A185039,A184... | Tiotropium is a long-acting, antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma.[A180163,L7084,L7087,L7090,L7093] Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and bronchodilation.[A180163,L7084,L... | Moderate | 1 | [
[
[
1405,
24,
1415
]
],
[
[
1405,
6,
8374
],
[
8374,
45,
1415
]
],
[
[
1405,
21,
28996
],
[
28996,
60,
1415
]
],
[
[
1405,
74,
1594
],
[
1... | [
[
[
"Cyclobenzaprine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tiotropium"
]
],
[
[
"Cyclobenzaprine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (C... | Cyclobenzaprine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Tiotropium (Compound)
Cyclobenzaprine (Compound) causes Musculoskeletal discomfort (Side Effect) and Musculoskeletal discomfort (Side Effect) is caused by Tiotropium (Compound)
Cyclobenzaprine (Compound) resembles Doxylamine (Compound) and Cyc... |
DB00889 | DB01255 | 1,133 | 633 | [
"DDInter840",
"DDInter1078"
] | Granisetron | Lisdexamfetamine | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Moderate | 1 | [
[
[
1133,
24,
633
]
],
[
[
1133,
64,
551
],
[
551,
1,
633
]
],
[
[
1133,
21,
28800
],
[
28800,
60,
633
]
],
[
[
1133,
23,
112
],
[
112,
... | [
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisdexamfetamine"
]
],
[
[
"Granisetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phenelzine"
],
[
"Ph... | Granisetron may lead to a major life threatening interaction when taken with Phenelzine and Phenelzine (Compound) resembles Lisdexamfetamine (Compound)
Granisetron (Compound) causes Dyskinesia (Side Effect) and Dyskinesia (Side Effect) is caused by Lisdexamfetamine (Compound)
Granisetron may cause a minor interaction t... |
DB00307 | DB00357 | 1,101 | 1,051 | [
"DDInter202",
"DDInter71"
] | Bexarotene | Aminoglutethimide | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Minor | 0 | [
[
[
1101,
23,
1051
]
],
[
[
1101,
6,
8374
],
[
8374,
45,
1051
]
],
[
[
1101,
21,
28803
],
[
28803,
60,
1051
]
],
[
[
1101,
24,
1411
],
[
1... | [
[
[
"Bexarotene",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Aminoglutethimide"
]
],
[
[
"Bexarotene",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compou... | Bexarotene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Aminoglutethimide (Compound)
Bexarotene (Compound) causes Anaemia (Side Effect) and Anaemia (Side Effect) is caused by Aminoglutethimide (Compound)
Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Tolbutami... |
DB00222 | DB00968 | 245 | 1,551 | [
"DDInter825",
"DDInter1185"
] | Glimepiride | Methyldopa | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Methyldopa, or α-methyldopa, is a centrally acting sympatholytic agent and an antihypertensive agent. It is an analog of DOPA (3,4‐hydroxyphenylanine), and it is a prodrug, meaning that the drug requires biotransformation to an active metabolite for therapeutic effects. Methyldopa works by binding to alpha(α)-2 adrener... | Minor | 0 | [
[
[
245,
23,
1551
]
],
[
[
245,
24,
817
],
[
817,
40,
1551
]
],
[
[
245,
24,
874
],
[
874,
24,
1551
]
],
[
[
245,
21,
28680
],
[
28680,
... | [
[
[
"Glimepiride",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Methyldopa"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dopamine"
],
[
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Dopamine and Dopamine (Compound) resembles Methyldopa (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a moderate interaction that could... |
DB01126 | DB08899 | 1,260 | 129 | [
"DDInter611",
"DDInter649"
] | Dutasteride | Enzalutamide | Dutasteride is an oral synthetic 4-azasteroid commonly marketed under the trade name Avodart. It is a novel dual 5α-reductase inhibitor that works by blocking both isoforms of 5α-reductase enzymes in a potent, selective, and irreversible manner. Type I and II 5α-reductase enzymes convert testosterone into dihydrotestos... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
1260,
24,
129
]
],
[
[
1260,
24,
918
],
[
918,
1,
129
]
],
[
[
1260,
6,
8374
],
[
8374,
45,
129
]
],
[
[
1260,
21,
28703
],
[
28703,
... | [
[
[
"Dutasteride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Dutasteride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
],
... | Dutasteride may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Dutasteride (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Dutasteride (Compound) causes Pruritus (Side Effect) and... |
DB00618 | DB09473 | 1,572 | 884 | [
"DDInter498",
"DDInter918"
] | Demeclocycline | Indium In-111 oxyquinoline | A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time. | Indium In 111 oxyquinoline (oxine) is a diagnostic radiopharmaceutical intended for radiolabeling of autologous leukocytes. It is composed of a 3:1 saturated complex of In-111 isotope and oxyquinoline. Indium-111 decays by isomeric transition and electron capture to cadmium-111, emitting a gamma ray that can be detecte... | Moderate | 1 | [
[
[
1572,
24,
884
]
],
[
[
1572,
1,
1545
],
[
1545,
24,
884
]
],
[
[
1572,
24,
319
],
[
319,
24,
884
]
],
[
[
1572,
40,
1620
],
[
1620,
... | [
[
[
"Demeclocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indium In-111 oxyquinoline"
]
],
[
[
"Demeclocycline",
"{u} (Compound) resembles {v} (Compound)",
"Oxytetracycline"
],
[
"Oxytetracyclin... | Demeclocycline (Compound) resembles Oxytetracycline (Compound) and Oxytetracycline may cause a moderate interaction that could exacerbate diseases when taken with Indium In-111 oxyquinoline
Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Amoxicillin and Amoxicillin may cau... |
DB00569 | DB14006 | 553 | 972 | [
"DDInter775",
"DDInter370"
] | Fondaparinux | Choline salicylate | Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in he... | Choline salicylate is an anti-inflammatory pain reliever agent that is related to aspirin. It is used to decrease swelling and to treat mild-moderate pain. It is used to treat arthritis in both children and adults. This medicine can also be used for fever . Choline Salicylate is the choline salt of salicylic acid, used... | Moderate | 1 | [
[
[
553,
24,
972
]
],
[
[
553,
64,
291
],
[
291,
24,
972
]
],
[
[
553,
25,
885
],
[
885,
24,
972
]
],
[
[
553,
24,
1039
],
[
1039,
2... | [
[
[
"Fondaparinux",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Choline salicylate"
]
],
[
[
"Fondaparinux",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Argatroban"
],
[
... | Fondaparinux may lead to a major life threatening interaction when taken with Argatroban and Argatroban may cause a moderate interaction that could exacerbate diseases when taken with Choline salicylate
Fondaparinux may lead to a major life threatening interaction when taken with Epoprostenol and Epoprostenol may cause... |
DB00226 | DB01364 | 1,000 | 22 | [
"DDInter845",
"DDInter650"
] | Guanadrel | Ephedrine | Guanadrel is an antihypertensive agent and postganglionic adrenergic blocking agent. | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Moderate | 1 | [
[
[
1000,
24,
22
]
],
[
[
1000,
24,
1445
],
[
1445,
1,
22
]
],
[
[
1000,
6,
7390
],
[
7390,
45,
22
]
],
[
[
1000,
24,
1220
],
[
1220,
... | [
[
[
"Guanadrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ephedrine"
]
],
[
[
"Guanadrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pseudoephedrine"
],
[
... | Guanadrel may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine and Pseudoephedrine (Compound) resembles Ephedrine (Compound)
Guanadrel (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Ephedrine (Compound)
Guanadrel may cause a moderate interaction that could exacer... |
DB00640 | DB06603 | 1,585 | 39 | [
"DDInter31",
"DDInter1387"
] | Adenosine | Panobinostat | The structure of adenosine was first described in 1931, though the vasodilating effects were not described in literature until the 1940s. Adenosine is indicated as an adjunct to thallium-201 in myocardial perfusion scintigraphy, though it is rarely used in this indication, having largely been replaced by [dipyridamole]... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
1585,
25,
39
]
],
[
[
1585,
23,
578
],
[
578,
63,
39
]
],
[
[
1585,
24,
688
],
[
688,
24,
39
]
],
[
[
1585,
40,
372
],
[
372,
24... | [
[
[
"Adenosine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Adenosine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ticagrelor"
],
[
"Ticagrelor",... | Adenosine may cause a minor interaction that can limit clinical effects when taken with Ticagrelor and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Panobinostat
Adenosine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutam... |
DB00372 | DB00489 | 999 | 17 | [
"DDInter1793",
"DDInter1704"
] | Thiethylperazine | Sotalol | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventric... | Moderate | 1 | [
[
[
999,
24,
17
]
],
[
[
999,
63,
88
],
[
88,
40,
17
]
],
[
[
999,
62,
417
],
[
417,
23,
17
]
],
[
[
999,
23,
1283
],
[
1283,
62,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sotalol"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoprolol"
],... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Metoprolol and Metoprolol (Compound) resembles Sotalol (Compound)
Thiethylperazine may cause a minor interaction that can limit clinical effects when taken with Sucralfate and Sucralfate may cause a minor interaction that c... |
DB00072 | DB10583 | 550 | 949 | [
"DDInter1846",
"DDInter415"
] | Trastuzumab | Clostridium tetani toxoid antigen (formaldehyde inactivated) | Produced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth factor receptor protein (HER2). It is used as a treatment of human epidermal growth ... | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Moderate | 1 | [
[
[
550,
24,
949
]
],
[
[
550,
25,
1377
],
[
1377,
24,
949
]
],
[
[
550,
24,
58
],
[
58,
24,
949
]
],
[
[
550,
25,
1259
],
[
1259,
6... | [
[
[
"Trastuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formaldehyde inactivated)"
]
],
[
[
"Trastuzumab",
"{u} may lead to a major life threatening interaction when taken with {v}... | Trastuzumab may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated)
Trastuzumab may cause a moderate interaction that could exacerbate disease... |
DB00055 | DB00586 | 834 | 1,512 | [
"DDInter605",
"DDInter537"
] | Drotrecogin alfa | Diclofenac | Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated th... | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Major | 2 | [
[
[
834,
25,
1512
]
],
[
[
834,
25,
1263
],
[
1263,
63,
1512
]
],
[
[
834,
64,
1271
],
[
1271,
24,
1512
]
],
[
[
834,
25,
598
],
[
598,
... | [
[
[
"Drotrecogin alfa",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Diclofenac"
]
],
[
[
"Drotrecogin alfa",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bromfenac"
],
[
"Bromfenac",
... | Drotrecogin alfa may lead to a major life threatening interaction when taken with Bromfenac and Bromfenac may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac
Drotrecogin alfa may lead to a major life threatening interaction when taken with Alteplase and Alteplase may cause a moder... |
DB00402 | DB12332 | 1,407 | 1,619 | [
"DDInter685",
"DDInter1626"
] | Eszopiclone | Rucaparib | Eszopiclone, marketed by Sepracor under the brand-name Lunesta, is a nonbenzodiazepine hypnotic drug used to treat insomnia. It is the active stereoisomer of zopiclone, belonging to the class of drugs known as _cyclopyrrolones_.[A179638,L6850] Cyclopyrrolone drugs demonstrate high efficacy and low toxicity, offering a ... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
1407,
24,
1619
]
],
[
[
1407,
24,
222
],
[
222,
23,
1619
]
],
[
[
1407,
24,
1419
],
[
1419,
24,
1619
]
],
[
[
1407,
24,
159
],
[
159,
... | [
[
[
"Eszopiclone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Eszopiclone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Eszopiclone may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Eszopiclone may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatini... |
DB00289 | DB11963 | 847 | 1,045 | [
"DDInter132",
"DDInter465"
] | Atomoxetine | Dacomitinib | Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD). Also known as the marketed product Strattera, atomoxetine is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve develop... | Dacomitinib, designed as (2E)-N-16-4-(piperidin-1-yl) but-2-enamide, is an oral highly selective quinazalone part of the second-generation tyrosine kinase inhibitors which are characterized by the irreversible binding at the ATP domain of the epidermal growth factor receptor family kinase domains. Dacomitinib was devel... | Major | 2 | [
[
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847,
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]
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[
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],
[
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[
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[
109,
... | [
[
[
"Atomoxetine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dacomitinib"
]
],
[
[
"Atomoxetine",
"{u} (Compound) resembles {v} (Compound)",
"Tolterodine"
],
[
"Tolterodine",
"{u} may cause a minor interaction... | Atomoxetine (Compound) resembles Tolterodine (Compound) and Tolterodine may cause a minor interaction that can limit clinical effects when taken with Dacomitinib
Atomoxetine may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine and Dexfenfluramine may cause a moderate interacti... |
DB08895 | DB12010 | 976 | 214 | [
"DDInter1825",
"DDInter785"
] | Tofacitinib | Fostamatinib | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
976,
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]
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[
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[
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[
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866
],
[
866,
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]
],
[
[
976,
62,
307
],
[
307,
24,... | [
[
[
"Tofacitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Tofacitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
... | Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Tofacitinib may lead to a major life threatening interaction when taken with Cobimetinib and Cobimetinib may ... |
DB00169 | DB00776 | 386 | 1,335 | [
"DDInter367",
"DDInter1360"
] | Cholecalciferol | Oxcarbazepine | Vitamin D, in general, is a secosteroid generated in the skin when 7-dehydrocholesterol located there interacts with ultraviolet irradiation - like that commonly found in sunlight. Both the endogenous form of vitamin D (that results from 7-dehydrocholesterol transformation), vitamin D3 (cholecalciferol), and the plant-... | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Moderate | 1 | [
[
[
386,
24,
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]
],
[
[
386,
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],
[
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]
],
[
[
386,
6,
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],
[
8374,
45,
1335
]
],
[
[
386,
25,
1098
],
[
1098,
... | [
[
[
"Cholecalciferol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxcarbazepine"
]
],
[
[
"Cholecalciferol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indapamide"
... | Cholecalciferol may cause a moderate interaction that could exacerbate diseases when taken with Indapamide and Indapamide (Compound) resembles Oxcarbazepine (Compound)
Cholecalciferol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Oxcarbazepine (Compound)
Cholecalciferol may lead to a major life threateni... |
DB00712 | DB06603 | 1,274 | 39 | [
"DDInter764",
"DDInter1387"
] | Flurbiprofen (ophthalmic) | Panobinostat | Flurbiprofen can cause developmental toxicity and female reproductive toxicity according to state or federal government labeling requirements. | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Moderate | 1 | [
[
[
1274,
37,
39
]
],
[
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1274,
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],
[
479,
23,
39
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[
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912
],
[
912,
24,
39
]
],
[
[
1274,
24,
1627
],
[
1627,
... | [
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Flurbiprofen",
"{u} may cause a minor interaction that ca... | Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Panobinostat and Flurbiprofen may lead to a major life threatening interaction when taken with Panobinostat
Flurbiprofen may cause a minor interaction that can limit clinical effects when taken with Donepezil and Donepezil may ... |
DB11932 | DB11978 | 327 | 124 | [
"DDInter3",
"DDInter822"
] | Abametapir (topical) | Glasdegib | Abametapir is a member of bipyridines. | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
327,
24,
124
]
],
[
[
327,
63,
79
],
[
79,
24,
124
]
],
[
[
327,
24,
1619
],
[
1619,
63,
124
]
],
[
[
327,
63,
702
],
[
702,
25,... | [
[
[
"Abametapir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Abametapir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sorafenib"
],
[
... | Abametapir may cause a moderate interaction that could exacerbate diseases when taken with Glasdegib
Abametapir may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Glasdegib
Abametapir may... |
DB00424 | DB00674 | 19 | 1,516 | [
"DDInter896",
"DDInter802"
] | Hyoscyamine | Galantamine | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease. First characterized in the early 1950s, galantamine is a tertiary alkaloid that was extracted from botanical sour... | Moderate | 1 | [
[
[
19,
24,
1516
]
],
[
[
19,
63,
475
],
[
475,
40,
1516
]
],
[
[
19,
24,
828
],
[
828,
40,
1516
]
],
[
[
19,
21,
28766
],
[
28766,
... | [
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Galantamine"
]
],
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Morphine"
],
[
... | Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine (Compound) resembles Galantamine (Compound)
Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone and Oxycodone (Compound) resembles Galantamine (Compound)
Hy... |
DB00816 | DB01244 | 1,674 | 762 | [
"DDInter1346",
"DDInter192"
] | Orciprenaline | Bepridil | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Major | 2 | [
[
[
1674,
25,
762
]
],
[
[
1674,
24,
939
],
[
939,
40,
762
]
],
[
[
1674,
63,
675
],
[
675,
40,
762
]
],
[
[
1674,
21,
28698
],
[
28698,
... | [
[
[
"Orciprenaline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bepridil"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzphetamine"
],
[
"Ben... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Benzphetamine and Benzphetamine (Compound) resembles Bepridil (Compound)
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Dextropropoxyphene and Dextropropoxyphene (Compound) resemb... |
DB09098 | DB14723 | 98 | 159 | [
"DDInter1700",
"DDInter1026"
] | Somatrem | Larotrectinib | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate. Such discussion revolves around whether patients' natural dispo... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
98,
24,
159
]
],
[
[
98,
63,
222
],
[
222,
23,
159
]
],
[
[
98,
24,
907
],
[
907,
23,
159
]
],
[
[
98,
62,
271
],
[
271,
23,
... | [
[
[
"Somatrem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Somatrem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Somatrem may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Somatrem may cause a moderate interaction that could exacerbate diseases when taken with Doravirine and Doravir... |
DB00341 | DB00532 | 1,242 | 208 | [
"DDInter343",
"DDInter1152"
] | Cetirizine | Mephenytoin | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subuni... | Moderate | 1 | [
[
[
1242,
24,
208
]
],
[
[
1242,
63,
475
],
[
475,
24,
208
]
],
[
[
1242,
24,
1219
],
[
1219,
63,
208
]
],
[
[
1242,
24,
530
],
[
530,
... | [
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mephenytoin"
]
],
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Morphine"
],
[
... | Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Mephenytoin
Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine and Azatadine ... |
DB09291 | DB11901 | 741 | 913 | [
"DDInter1615",
"DDInter107"
] | Rolapitant | Apalutamide | Rolapitant is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and vomiting (CINV) in adults. Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated by Neurokinin-1 and its l... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Major | 2 | [
[
[
741,
25,
913
]
],
[
[
741,
63,
1237
],
[
1237,
24,
913
]
],
[
[
741,
24,
1320
],
[
1320,
63,
913
]
],
[
[
741,
64,
888
],
[
888,
... | [
[
[
"Rolapitant",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apalutamide"
]
],
[
[
"Rolapitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
],
[
"Clomipr... | Rolapitant may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Rolapitant may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Ela... |
DB00401 | DB12332 | 84 | 1,619 | [
"DDInter1298",
"DDInter1626"
] | Nisoldipine | Rucaparib | Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contractio... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
84,
24,
1619
]
],
[
[
84,
24,
259
],
[
259,
24,
1619
]
],
[
[
84,
63,
58
],
[
58,
24,
1619
]
],
[
[
84,
24,
159
],
[
159,
63,
... | [
[
[
"Nisoldipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Nisoldipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
],
[
... | Nisoldipine may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib
Nisoldipine may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefac... |
DB00312 | DB00539 | 1,023 | 11 | [
"DDInter1423",
"DDInter1837"
] | Pentobarbital | Toremifene | A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Dr... | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Moderate | 1 | [
[
[
1023,
24,
11
]
],
[
[
1023,
24,
1594
],
[
1594,
40,
11
]
],
[
[
1023,
6,
8374
],
[
8374,
45,
11
]
],
[
[
1023,
21,
28722
],
[
28722,
... | [
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Toremifene"
]
],
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
... | Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine (Compound) resembles Toremifene (Compound)
Pentobarbital (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Toremifene (Compound)
Pentobarbital (Compound) causes Nausea (Side Effect) and Nau... |
DB00361 | DB00445 | 134 | 322 | [
"DDInter1939",
"DDInter655"
] | Vinorelbine | Epirubicin | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Moderate | 1 | [
[
[
134,
24,
322
]
],
[
[
134,
5,
11583
],
[
11583,
44,
322
]
],
[
[
134,
7,
3641
],
[
3641,
45,
322
]
],
[
[
134,
7,
9489
],
[
9489,
... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
]
],
[
[
"Vinorelbine",
"{u} (Compound) treats {v} (Disease)",
"ovarian cancer"
],
[
"ovarian cancer",
"{u} (Disease) is ... | Vinorelbine (Compound) treats ovarian cancer (Disease) and ovarian cancer (Disease) is treated by Epirubicin (Compound)
Vinorelbine (Compound) upregulates DHCR7 (Gene) and DHCR7 (Gene) is bound by Epirubicin (Compound)
Vinorelbine (Compound) upregulates WIF1 (Gene) and WIF1 (Gene) is upregulated by Epirubicin (Compound... |
DB00651 | DB01336 | 746 | 545 | [
"DDInter613",
"DDInter1198"
] | Dyphylline | Metocurine | Dyphylline is a theophylline derivative with broncho- and vasodilator properties. It is typically used in the management of asthma, cardiac dyspnea, and bronchitis. | Dimethyltubocurarinium (INN) or metocurine (USAN), also known as dimethyltubocurarine, is a non-depolarizing muscle relaxant. Patients on chronic anticonvulsant drugs are relatively resistant to metocurine. | Moderate | 1 | [
[
[
746,
24,
545
]
],
[
[
746,
24,
1217
],
[
1217,
40,
545
]
],
[
[
746,
40,
1031
],
[
1031,
24,
545
]
],
[
[
746,
24,
1217
],
[
1217,
... | [
[
[
"Dyphylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metocurine"
]
],
[
[
"Dyphylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tubocurarine"
],
[
... | Dyphylline may cause a moderate interaction that could exacerbate diseases when taken with Tubocurarine and Tubocurarine (Compound) resembles Metocurine (Compound)
Dyphylline (Compound) resembles Theophylline (Compound) and Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Met... |
DB00800 | DB08824 | 572 | 591 | [
"DDInter720",
"DDInter959"
] | Fenoldopam | Ioflupane I-123 | A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation. | Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes. | Moderate | 1 | [
[
[
572,
24,
591
]
],
[
[
572,
21,
28722
],
[
28722,
60,
591
]
],
[
[
572,
24,
401
],
[
401,
24,
591
]
],
[
[
572,
63,
999
],
[
999,
... | [
[
[
"Fenoldopam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioflupane I-123"
]
],
[
[
"Fenoldopam",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is cause... | Fenoldopam (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Ioflupane I-123 (Compound)
Fenoldopam may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Iofl... |
DB00867 | DB01064 | 1,052 | 1,148 | [
"DDInter1606",
"DDInter987"
] | Ritodrine | Isoprenaline | Adrenergic beta-agonist used to control premature labor. | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Moderate | 1 | [
[
[
1052,
24,
1148
]
],
[
[
1052,
63,
1636
],
[
1636,
24,
1148
]
],
[
[
1052,
40,
1188
],
[
1188,
1,
1148
]
],
[
[
1052,
35,
480
],
[
480,... | [
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
]
],
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylephrine"
],
[... | Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine and Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Ritodrine (Compound) resembles Arbutamine (Compound) and Arbutamine (Compound) resembles Isoprenaline (Co... |
DB00334 | DB00341 | 867 | 1,242 | [
"DDInter1326",
"DDInter343"
] | Olanzapine | Cetirizine | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms , . One of the most common uses for this drug is for a condition called _alle... | Moderate | 1 | [
[
[
867,
24,
1242
]
],
[
[
867,
24,
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],
[
537,
63,
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]
],
[
[
867,
6,
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],
[
10104,
45,
1242
]
],
[
[
867,
64,
475
],
[
475,
... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cetirizine"
]
],
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
],
[
... | Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine
Olanzapine (Compound) binds HRH1 (Gene) and HRH1 (Gene) is bound by Cetirizine (Compound)
Olanzapine may lead to a... |
DB00635 | DB14006 | 1,573 | 972 | [
"DDInter1515",
"DDInter370"
] | Prednisone | Choline salicylate | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Choline salicylate is an anti-inflammatory pain reliever agent that is related to aspirin. It is used to decrease swelling and to treat mild-moderate pain. It is used to treat arthritis in both children and adults. This medicine can also be used for fever . Choline Salicylate is the choline salt of salicylic acid, used... | Moderate | 1 | [
[
[
1573,
24,
972
]
],
[
[
1573,
23,
771
],
[
771,
62,
972
]
],
[
[
1573,
63,
176
],
[
176,
24,
972
]
],
[
[
1573,
23,
1117
],
[
1117,
... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Choline salicylate"
]
],
[
[
"Prednisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
],... | Prednisone may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase and Hyaluronidase may cause a minor interaction that can limit clinical effects when taken with Choline salicylate
Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Insulin gla... |
DB00959 | DB01357 | 1,486 | 890 | [
"DDInter1191",
"DDInter1160"
] | Methylprednisolone | Mestranol | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | The 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives. | Moderate | 1 | [
[
[
1486,
24,
890
]
],
[
[
1486,
24,
35
],
[
35,
40,
890
]
],
[
[
1486,
63,
380
],
[
380,
40,
890
]
],
[
[
1486,
63,
559
],
[
559,
1... | [
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mestranol"
]
],
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinestrol"
... | Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Quinestrol and Quinestrol (Compound) resembles Mestranol (Compound)
Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Conjugated estrogens and Conjugated estrogens (Compoun... |
DB00348 | DB09048 | 254 | 555 | [
"DDInter1300",
"DDInter1284"
] | Nitisinone | Netupitant | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Netupitant is an antiemitic drug approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy. Netupitant is a neurokinin 1 receptor antagonist. The combination drug i... | Moderate | 1 | [
[
[
254,
24,
555
]
],
[
[
254,
63,
1101
],
[
1101,
23,
555
]
],
[
[
254,
24,
283
],
[
283,
62,
555
]
],
[
[
254,
24,
1573
],
[
1573,
... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Netupitant"
]
],
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Netupitant
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratin... |
DB00059 | DB00407 | 1,560 | 202 | [
"DDInter1404",
"DDInter115"
] | Pegaspargase | Ardeparin | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Ardeparin, marketed under the US trade name Normiflo, is a low molecular weight heparin (LMWH) anticoagulant used for the prevention of postoperative venous thrombosis. Ardeparin is derived via peroxide degradation of heparin extracted from porcine intestinal mucosa. Its molecular weight ranges from 2000 to 15,000 with... | Moderate | 1 | [
[
[
1560,
24,
202
]
],
[
[
1560,
24,
1151
],
[
1151,
63,
202
]
],
[
[
1560,
24,
1468
],
[
1468,
64,
202
]
],
[
[
1560,
24,
1018
],
[
1018,... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ardeparin"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
],
[
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Sunitinib and Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Ardeparin
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib and Ponati... |
DB08870 | DB15091 | 850 | 676 | [
"DDInter228",
"DDInter1901"
] | Brentuximab vedotin | Upadacitinib | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
850,
25,
676
]
],
[
[
850,
63,
1430
],
[
1430,
24,
676
]
],
[
[
850,
24,
748
],
[
748,
24,
676
]
],
[
[
850,
24,
1654
],
[
1654,
... | [
[
[
"Brentuximab vedotin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
],
... | Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Upadacitinib
Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB08815 | DB12015 | 154 | 1,033 | [
"DDInter1104",
"DDInter53"
] | Lurasidone | Alpelisib | Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States. | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
154,
24,
1033
]
],
[
[
154,
63,
1254
],
[
1254,
24,
1033
]
],
[
[
154,
24,
1344
],
[
1344,
24,
1033
]
],
[
[
154,
25,
760
],
[
760,
... | [
[
[
"Lurasidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Lurasidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
],
... | Lurasidone may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine and Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Lurasidone may cause a moderate interaction that could exacerbate diseases when taken with Canaglif... |
DB00872 | DB06697 | 1,080 | 436 | [
"DDInter438",
"DDInter121"
] | Conivaptan | Artemether | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Artemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of <i>Plasmodium spp.</i> and may be used to treat infections caused by <i>P. falciparum</... | Major | 2 | [
[
[
1080,
25,
436
]
],
[
[
1080,
6,
8374
],
[
8374,
45,
436
]
],
[
[
1080,
25,
283
],
[
283,
63,
436
]
],
[
[
1080,
24,
1220
],
[
1220,
... | [
[
[
"Conivaptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Artemether"
]
],
[
[
"Conivaptan",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Artemet... | Conivaptan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Artemether (Compound)
Conivaptan may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Artemether
Conivaptan may cause a moderate i... |
DB00059 | DB00065 | 1,560 | 581 | [
"DDInter1404",
"DDInter923"
] | Pegaspargase | Infliximab | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions . Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory... | Major | 2 | [
[
[
1560,
25,
581
]
],
[
[
1560,
24,
221
],
[
221,
63,
581
]
],
[
[
1560,
24,
912
],
[
912,
24,
581
]
],
[
[
1560,
63,
1451
],
[
1451,
... | [
[
[
"Pegaspargase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Infliximab"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyd... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated) and Poliovirus type 1 antigen (formaldehyde inactivated) may cause a moderate interaction that could exacerbate diseases when taken with Infliximab
Pegaspargase may cause a m... |
DB00108 | DB00432 | 1,066 | 1,083 | [
"DDInter1268",
"DDInter1868"
] | Natalizumab | Trifluridine | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | Trifluridine is a fluorinated pyrimidine nucleoside that is structurally related to [idoxuridine] . It is an active antiviral agent in ophthalmic solutions used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus. It displays effective antiviral activit... | Major | 2 | [
[
[
1066,
25,
1083
]
],
[
[
1066,
25,
1238
],
[
1238,
1,
1083
]
],
[
[
1066,
25,
139
],
[
139,
63,
1083
]
],
[
[
1066,
24,
1367
],
[
1367,... | [
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trifluridine"
]
],
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pentostatin"
],
[
"Pentostatin",
... | Natalizumab may lead to a major life threatening interaction when taken with Pentostatin and Pentostatin (Compound) resembles Trifluridine (Compound)
Natalizumab may lead to a major life threatening interaction when taken with Zidovudine and Zidovudine may cause a moderate interaction that could exacerbate diseases whe... |
DB00986 | DB01246 | 1,192 | 820 | [
"DDInter834",
"DDInter45"
] | Glycopyrronium | Alimemazine | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
1192,
24,
820
]
],
[
[
1192,
24,
358
],
[
358,
24,
820
]
],
[
[
1192,
63,
104
],
[
104,
40,
820
]
],
[
[
1192,
63,
1405
],
[
1405,
... | [
[
[
"Glycopyrronium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Glycopyrronium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orphenadrine"
... | Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Methdila... |
DB00635 | DB06718 | 1,573 | 1,687 | [
"DDInter1515",
"DDInter1709"
] | Prednisone | Stanozolol | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Stanozolol is a synthetic anabolic steroid with therapeutic uses in treating hereditary angioedema. Stanozolol is derived from testosterone, and has been abused by several high profile professional athletes. | Moderate | 1 | [
[
[
1573,
24,
1687
]
],
[
[
1573,
35,
1546
],
[
1546,
1,
1687
]
],
[
[
1573,
63,
1561
],
[
1561,
40,
1687
]
],
[
[
1573,
24,
155
],
[
155,... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stanozolol"
]
],
[
[
"Prednisone",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken w... | Prednisone (Compound) resembles Methyltestosterone (Compound) and Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Methyltestosterone and Methyltestosterone (Compound) resembles Stanozolol (Compound)
Prednisone may cause a moderate interaction that could exacerbate diseases whe... |
DB00476 | DB06605 | 109 | 1,409 | [
"DDInter608",
"DDInter108"
] | Duloxetine | Apixaban | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Moderate | 1 | [
[
[
109,
24,
1409
]
],
[
[
109,
6,
7950
],
[
7950,
45,
1409
]
],
[
[
109,
21,
29666
],
[
29666,
60,
1409
]
],
[
[
109,
25,
1670
],
[
1670,... | [
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apixaban"
]
],
[
[
"Duloxetine",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
... | Duloxetine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Apixaban (Compound)
Duloxetine (Compound) causes Melaena (Side Effect) and Melaena (Side Effect) is caused by Apixaban (Compound)
Duloxetine may lead to a major life threatening interaction when taken with Eliglustat and Eliglustat may cause a mode... |
DB01116 | DB01142 | 601 | 1,264 | [
"DDInter1872",
"DDInter593"
] | Trimethaphan | Doxepin | A nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hypotension during surgery. | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
601,
24,
1264
]
],
[
[
601,
63,
401
],
[
401,
24,
1264
]
],
[
[
601,
40,
939
],
[
939,
24,
1264
]
],
[
[
601,
24,
407
],
[
407,
... | [
[
[
"Trimethaphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Trimethaphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[... | Trimethaphan may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Trimethaphan (Compound) resembles Benzphetamine (Compound) and Benzphetamine may cause a moderate interaction... |
DB00413 | DB00792 | 1,346 | 832 | [
"DDInter1505",
"DDInter1878"
] | Pramipexole | Tripelennamine | Pramipexole is a drug used to treat the symptoms of Parkinson's Disease (PD). It is a _non-ergot dopamine agonist_ drug that is efficacious in treating various Parkinson's symptoms such as tremor, rigidity, and bradykinesia (slow movement). It was first approved by the FDA in 1997. Parkinson's Disease is one of the mos... | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Moderate | 1 | [
[
[
1346,
24,
832
]
],
[
[
1346,
24,
100
],
[
100,
63,
832
]
],
[
[
1346,
24,
649
],
[
649,
1,
832
]
],
[
[
1346,
63,
1594
],
[
1594,
... | [
[
[
"Pramipexole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
]
],
[
[
"Pramipexole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
... | Pramipexole may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine
Pramipexole may cause a moderate interaction that could exacerbate diseases when taken with Clofe... |
DB01125 | DB06206 | 279 | 1,268 | [
"DDInter98",
"DDInter1719"
] | Anisindione | Sugammadex | Anisindione is a synthetic anticoagulant and an indanedione derivative. Its anticoagulant action is mediated through the inhibition of the vitamin K-mediated gamma-carboxylation of precursor proteins that are critical in forming the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagu... | Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery. Rocuronium bromide and vecuronium bromide are neuromuscular blocking medications that cause temporary paralysis and are especially useful for general ane... | Moderate | 1 | [
[
[
279,
24,
1268
]
],
[
[
279,
63,
11
],
[
11,
24,
1268
]
],
[
[
279,
64,
291
],
[
291,
24,
1268
]
],
[
[
279,
25,
1409
],
[
1409,
... | [
[
[
"Anisindione",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sugammadex"
]
],
[
[
"Anisindione",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Toremifene"
],
[
... | Anisindione may cause a moderate interaction that could exacerbate diseases when taken with Toremifene and Toremifene may cause a moderate interaction that could exacerbate diseases when taken with Sugammadex
Anisindione may lead to a major life threatening interaction when taken with Argatroban and Argatroban may caus... |
DB06282 | DB09420 | 516 | 1,074 | [
"DDInter1053",
"DDInter953"
] | Levocetirizine | Iodide I-123 | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Moderate | 1 | [
[
[
516,
24,
1074
]
],
[
[
516,
24,
849
],
[
849,
24,
1074
]
],
[
[
516,
63,
902
],
[
902,
24,
1074
]
],
[
[
516,
24,
1399
],
[
1399,
... | [
[
[
"Levocetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
]
],
[
[
"Levocetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]... | Levocetirizine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123
Levocetirizine may cause a moderate interaction that could exacerbate diseases when taken with Clobazam an... |
DB00697 | DB01069 | 876 | 401 | [
"DDInter1821",
"DDInter1533"
] | Tizanidine | Promethazine | Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury. It may also be caused by musculoskeletal injury. Regardless of the cause, muscle spasticity can be an extremely painful and debili... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
876,
24,
401
]
],
[
[
876,
24,
1264
],
[
1264,
63,
401
]
],
[
[
876,
24,
104
],
[
104,
24,
401
]
],
[
[
876,
21,
28775
],
[
28775,
... | [
[
[
"Tizanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Tizanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Tizanidine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Tizanidine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdila... |
DB01285 | DB10276 | 708 | 1,624 | [
"DDInter445",
"DDInter1623"
] | Corticotropin | Rotavirus vaccine | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Major | 2 | [
[
[
708,
25,
1624
]
],
[
[
708,
63,
1648
],
[
1648,
25,
1624
]
],
[
[
708,
25,
375
],
[
375,
25,
1624
]
],
[
[
708,
24,
270
],
[
270,
... | [
[
[
"Corticotropin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Corticotropin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
],
[
... | Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may lead to a major life threatening interaction when taken with Rotavirus vaccine
Corticotropin may lead to a major life threatening interaction when taken with Certolizumab pegol and Certolizumab ... |
DB01097 | DB01211 | 1,377 | 609 | [
"DDInter1033",
"DDInter393"
] | Leflunomide | Clarithromycin | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Major | 2 | [
[
[
1377,
25,
609
]
],
[
[
1377,
64,
1570
],
[
1570,
24,
609
]
],
[
[
1377,
6,
7950
],
[
7950,
45,
609
]
],
[
[
1377,
18,
18226
],
[
18226... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
]
],
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Azithromycin"
],
[
"Azithromycin",
... | Leflunomide may lead to a major life threatening interaction when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Leflunomide (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Clarithromycin (Compound)
Leflunomide (Compou... |
DB00214 | DB01075 | 1,028 | 1,376 | [
"DDInter1836",
"DDInter569"
] | Torasemide | Diphenhydramine | Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993. | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
1028,
24,
1376
]
],
[
[
1028,
24,
11
],
[
11,
1,
1376
]
],
[
[
1028,
24,
401
],
[
401,
24,
1376
]
],
[
[
1028,
24,
888
],
[
888,
... | [
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Toremifene"
],
... | Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Toremifene and Toremifene (Compound) resembles Diphenhydramine (Compound)
Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction t... |
DB00328 | DB01050 | 831 | 848 | [
"DDInter921",
"DDInter900"
] | Indomethacin | Ibuprofen | Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlor... | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Moderate | 1 | [
[
[
831,
24,
848
]
],
[
[
831,
40,
734
],
[
734,
1,
848
]
],
[
[
831,
6,
1829
],
[
1829,
45,
848
]
],
[
[
831,
10,
11666
],
[
11666,
... | [
[
[
"Indomethacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
]
],
[
[
"Indomethacin",
"{u} (Compound) resembles {v} (Compound)",
"Naproxen"
],
[
"Naproxen",
"{u} (Compound) resembles... | Indomethacin (Compound) resembles Naproxen (Compound) and Naproxen (Compound) resembles Ibuprofen (Compound)
Indomethacin (Compound) binds ALB (Gene) and ALB (Gene) is bound by Ibuprofen (Compound)
Indomethacin (Compound) palliates osteoarthritis (Disease) and osteoarthritis (Disease) is palliated by Ibuprofen (Compoun... |
DB00465 | DB09133 | 886 | 1,527 | [
"DDInter1010",
"DDInter965"
] | Ketorolac | Iothalamic acid | Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, men... | Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent. | Major | 2 | [
[
[
886,
25,
1527
]
],
[
[
886,
24,
91
],
[
91,
25,
1527
]
],
[
[
886,
25,
1512
],
[
1512,
25,
1527
]
],
[
[
886,
1,
24
],
[
24,
25,... | [
[
[
"Ketorolac",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iothalamic acid"
]
],
[
[
"Ketorolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vancomycin"
],
[
"Vancomy... | Ketorolac may cause a moderate interaction that could exacerbate diseases when taken with Vancomycin and Vancomycin may lead to a major life threatening interaction when taken with Iothalamic acid
Ketorolac may lead to a major life threatening interaction when taken with Diclofenac and Diclofenac may lead to a major li... |
DB00726 | DB00816 | 1,164 | 1,674 | [
"DDInter1876",
"DDInter1346"
] | Trimipramine | Orciprenaline | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Moderate | 1 | [
[
[
1164,
24,
1674
]
],
[
[
1164,
64,
874
],
[
874,
24,
1674
]
],
[
[
1164,
21,
28921
],
[
28921,
60,
1674
]
],
[
[
1164,
24,
959
],
[
959... | [
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orciprenaline"
]
],
[
[
"Trimipramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Epinephrine"
],
[
"Ep... | Trimipramine may lead to a major life threatening interaction when taken with Epinephrine and Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Orciprenaline
Trimipramine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Orciprenaline (Compound)... |
DB00970 | DB06372 | 0 | 259 | [
"DDInter466",
"DDInter1594"
] | Dactinomycin | Rilonacept | A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also d... | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
0,
24,
259
]
],
[
[
0,
63,
1461
],
[
1461,
23,
259
]
],
[
[
0,
24,
37
],
[
37,
24,
259
]
],
[
[
0,
24,
1330
],
[
1330,
63,
... | [
[
[
"Dactinomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Dactinomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[... | Dactinomycin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Rilonacept
Dactinomycin may cause a moderate interaction that could exacerbate diseases when taken with Lomustine and Lomusti... |
DB00835 | DB01618 | 100 | 776 | [
"DDInter245",
"DDInter1239"
] | Brompheniramine | Molindone | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to mo... | Moderate | 1 | [
[
[
100,
24,
776
]
],
[
[
100,
6,
7992
],
[
7992,
45,
776
]
],
[
[
100,
63,
1442
],
[
1442,
24,
776
]
],
[
[
100,
35,
272
],
[
272,
... | [
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Molindone"
]
],
[
[
"Brompheniramine",
"{u} (Compound) binds {v} (Gene)",
"CHRM1"
],
[
"CHRM1",
"{u} (Gene) is bound by {v} (Comp... | Brompheniramine (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Molindone (Compound)
Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Scopolamine and Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Molindone
Bromphenir... |
DB00736 | DB00758 | 660 | 1,347 | [
"DDInter676",
"DDInter413"
] | Esomeprazole | Clopidogrel | Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory... | Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recen... | Major | 2 | [
[
[
660,
25,
1347
]
],
[
[
660,
6,
10215
],
[
10215,
45,
1347
]
],
[
[
660,
21,
29402
],
[
29402,
60,
1347
]
],
[
[
660,
63,
1028
],
[
102... | [
[
[
"Esomeprazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clopidogrel"
]
],
[
[
"Esomeprazole",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compound)",
"... | Esomeprazole (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Clopidogrel (Compound)
Esomeprazole (Compound) causes Hepatobiliary disease (Side Effect) and Hepatobiliary disease (Side Effect) is caused by Clopidogrel (Compound)
Esomeprazole may cause a moderate interaction that could exacerbate diseases w... |
DB00382 | DB00539 | 62 | 11 | [
"DDInter1734",
"DDInter1837"
] | Tacrine | Toremifene | A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market. | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Moderate | 1 | [
[
[
62,
24,
11
]
],
[
[
62,
63,
1594
],
[
1594,
40,
11
]
],
[
[
62,
24,
1376
],
[
1376,
40,
11
]
],
[
[
62,
24,
112
],
[
112,
62,
... | [
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Toremifene"
]
],
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[
"D... | Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine (Compound) resembles Toremifene (Compound)
Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine (Compound) resembles Toremifene (Compou... |
DB00026 | DB12267 | 1,184 | 1,476 | [
"DDInter94",
"DDInter233"
] | Anakinra | Brigatinib | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
1184,
24,
1476
]
],
[
[
1184,
24,
168
],
[
168,
23,
1476
]
],
[
[
1184,
24,
629
],
[
629,
24,
1476
]
],
[
[
1184,
24,
180
],
[
180,
... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus may... |
DB00395 | DB01612 | 210 | 1,637 | [
"DDInter301",
"DDInter92"
] | Carisoprodol | Amyl Nitrite | Originally approved by the FDA in 1959 [FDA label], carisoprodol is a centrally acting muscle relaxant used in painful musculoskeletal conditions in conjunction with physical therapy and other medications. This drug is available by itself in an oral tablet or combined with aspirin, or in a fixed-dose combination with b... | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Moderate | 1 | [
[
[
210,
24,
1637
]
],
[
[
210,
64,
475
],
[
475,
24,
1637
]
],
[
[
210,
24,
401
],
[
401,
24,
1637
]
],
[
[
210,
24,
407
],
[
407,
... | [
[
[
"Carisoprodol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Carisoprodol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Morphine"
],
[
"Morphi... | Carisoprodol may lead to a major life threatening interaction when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Carisoprodol may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may ... |
DB00448 | DB01269 | 1,215 | 38 | [
"DDInter1022",
"DDInter1386"
] | Lansoprazole | Panitumumab | Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole. It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux ... | Panitumumab (ABX-EGF) is a recombinant human IgG2 monoclonal antibody that binds specifically to the human epidermal growth factor receptor (EGFR). This drug is an antineoplastic agent. Panitumumab was granted FDA approval on 27 September 2006. | Moderate | 1 | [
[
[
1215,
24,
38
]
],
[
[
1215,
40,
660
],
[
660,
24,
38
]
],
[
[
1215,
40,
660
],
[
660,
1,
379
],
[
379,
24,
38
]
],
[
[
1215,
40,... | [
[
[
"Lansoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Panitumumab"
]
],
[
[
"Lansoprazole",
"{u} (Compound) resembles {v} (Compound)",
"Esomeprazole"
],
[
"Esomeprazole",
"{u} may cause ... | Lansoprazole (Compound) resembles Esomeprazole (Compound) and Esomeprazole may cause a moderate interaction that could exacerbate diseases when taken with Panitumumab
Lansoprazole (Compound) resembles Esomeprazole (Compound) and Esomeprazole (Compound) resembles Rabeprazole (Compound) and Rabeprazole may cause a modera... |
DB00054 | DB05578 | 1,432 | 330 | [
"DDInter6",
"DDInter1566"
] | Abciximab | Ramucirumab | Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (αv... | Ramucirumab is a human monoclonal antibody (IgG1) against vascular endothelial growth factor receptor 2 (VEGFR2), a type II trans-membrane tyrosine kinase receptor expressed on endothelial cells. By binding to VEGFR2, ramucirumab prevents binding of its ligands (VEGF-A, VEGF-C, and VEGF-D), thereby preventing VEGF-stim... | Major | 2 | [
[
[
1432,
25,
330
]
],
[
[
1432,
24,
41
],
[
41,
63,
330
]
],
[
[
1432,
24,
901
],
[
901,
24,
330
]
],
[
[
1432,
25,
1317
],
[
1317,
... | [
[
[
"Abciximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ramucirumab"
]
],
[
[
"Abciximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
],
[
"Levomi... | Abciximab may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran and Levomilnacipran may cause a moderate interaction that could exacerbate diseases when taken with Ramucirumab
Abciximab may cause a moderate interaction that could exacerbate diseases when taken with Milnacipran ... |
DB00948 | DB01082 | 1,681 | 1,448 | [
"DDInter1207",
"DDInter1713"
] | Mezlocillin | Streptomycin | Semisynthetic ampicillin-derived acylureido penicillin. It has been proposed for infections with certain anaerobes and may be useful in inner ear, bile, and CNS infections. | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | Moderate | 1 | [
[
[
1681,
24,
1448
]
],
[
[
1681,
40,
1323
],
[
1323,
63,
1448
]
],
[
[
1681,
24,
1662
],
[
1662,
63,
1448
]
],
[
[
1681,
40,
790
],
[
790... | [
[
[
"Mezlocillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Streptomycin"
]
],
[
[
"Mezlocillin",
"{u} (Compound) resembles {v} (Compound)",
"Cefonicid"
],
[
"Cefonicid",
"{u} may cause a moder... | Mezlocillin (Compound) resembles Cefonicid (Compound) and Cefonicid may cause a moderate interaction that could exacerbate diseases when taken with Streptomycin
Mezlocillin may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid and Picosulfuric acid may cause a moderate intera... |
DB00046 | DB01197 | 1,179 | 1,603 | [
"DDInter940",
"DDInter292"
] | Insulin lispro | Captopril | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment ... | Moderate | 1 | [
[
[
1179,
24,
1603
]
],
[
[
1179,
24,
610
],
[
610,
1,
1603
]
],
[
[
1179,
24,
1019
],
[
1019,
63,
1603
]
],
[
[
1179,
24,
959
],
[
959,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Captopril"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enalapril"
],
... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Enalapril and Enalapril (Compound) resembles Captopril (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort and Deflazacort may cause a moderate interaction tha... |
DB04865 | DB05273 | 4 | 507 | [
"DDInter1335",
"DDInter1638"
] | Omacetaxine mepesuccinate | Samarium (153Sm) lexidronam | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.Samarium ... | Major | 2 | [
[
[
4,
25,
507
]
],
[
[
4,
63,
248
],
[
248,
24,
507
]
],
[
[
4,
24,
270
],
[
270,
63,
507
]
],
[
[
4,
63,
196
],
[
196,
25,
5... | [
[
[
"Omacetaxine mepesuccinate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Samarium (153Sm) lexidronam"
]
],
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Valganciclovir and Valganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Samarium (153Sm) lexidronam
Omacetaxine mepesuccinate may cause a moderate interaction that could ex... |
DB00812 | DB11986 | 998 | 484 | [
"DDInter1451",
"DDInter648"
] | Phenylbutazone | Entrectinib | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
998,
24,
484
]
],
[
[
998,
24,
466
],
[
466,
62,
484
]
],
[
[
998,
24,
1135
],
[
1135,
23,
484
]
],
[
[
998,
24,
1662
],
[
1662,
... | [
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
... | Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol ... |
DB00682 | DB06209 | 126 | 256 | [
"DDInter1951",
"DDInter1508"
] | Warfarin | Prasugrel | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversib... | Major | 2 | [
[
[
126,
25,
256
]
],
[
[
126,
6,
10215
],
[
10215,
45,
256
]
],
[
[
126,
23,
944
],
[
944,
62,
256
]
],
[
[
126,
24,
101
],
[
101,
... | [
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prasugrel"
]
],
[
[
"Warfarin",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compound)",
"Prasugrel"... | Warfarin (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Prasugrel (Compound)
Warfarin may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Prasugrel
Warfarin may cause a moderat... |
DB00348 | DB00731 | 254 | 1,144 | [
"DDInter1300",
"DDInter1269"
] | Nitisinone | Nateglinide | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Moderate | 1 | [
[
[
254,
24,
1144
]
],
[
[
254,
21,
29222
],
[
29222,
60,
1144
]
],
[
[
254,
24,
804
],
[
804,
62,
1144
]
],
[
[
254,
24,
1051
],
[
1051,
... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
]
],
[
[
"Nitisinone",
"{u} (Compound) causes {v} (Side Effect)",
"Hypoglycaemia"
],
[
"Hypoglycaemia",
"{u} (Side Effect... | Nitisinone (Compound) causes Hypoglycaemia (Side Effect) and Hypoglycaemia (Side Effect) is caused by Nateglinide (Compound)
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Sulfinpyrazone and Sulfinpyrazone may cause a minor interaction that can limit clinical effects when tak... |
DB00436 | DB09082 | 323 | 659 | [
"DDInter179",
"DDInter1934"
] | Bendroflumethiazide | Vilanterol | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810) | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
323,
24,
659
]
],
[
[
323,
24,
1220
],
[
1220,
23,
659
]
],
[
[
323,
63,
218
],
[
218,
23,
659
]
],
[
[
323,
24,
1296
],
[
1296,
... | [
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexametha... | Bendroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Bendroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with... |
DB01211 | DB12364 | 609 | 1,421 | [
"DDInter393",
"DDInter200"
] | Clarithromycin | Betrixaban | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Major | 2 | [
[
[
609,
25,
1421
]
],
[
[
609,
62,
1091
],
[
1091,
24,
1421
]
],
[
[
609,
25,
1017
],
[
1017,
24,
1421
]
],
[
[
609,
63,
529
],
[
529,
... | [
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betrixaban"
]
],
[
[
"Clarithromycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amprenavir"
],
[
"Ampr... | Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Amprenavir and Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Clarithromycin may lead to a major life threatening interaction when taken with Lorlatinib and Lorlatinib may ... |
DB00861 | DB04932 | 914 | 1,564 | [
"DDInter551",
"DDInter491"
] | Diflunisal | Defibrotide | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Da... | Moderate | 1 | [
[
[
914,
24,
1564
]
],
[
[
914,
24,
1039
],
[
1039,
24,
1564
]
],
[
[
914,
24,
738
],
[
738,
63,
1564
]
],
[
[
914,
63,
121
],
[
121,
... | [
[
[
"Diflunisal",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Defibrotide"
]
],
[
[
"Diflunisal",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexfenfluramine"
],
... | Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine and Dexfenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Defibrotide
Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Niraparib ... |
DB01238 | DB12245 | 673 | 823 | [
"DDInter118",
"DDInter1863"
] | Aripiprazole | Triclabendazole | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
673,
24,
823
]
],
[
[
673,
62,
112
],
[
112,
23,
823
]
],
[
[
673,
63,
1010
],
[
1010,
24,
823
]
],
[
[
673,
24,
1151
],
[
1151,
... | [
[
[
"Aripiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Aripiprazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
]... | Aripiprazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Aripiprazole may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine... |
DB00780 | DB00912 | 551 | 473 | [
"DDInter1440",
"DDInter1581"
] | Phenelzine | Repaglinide | Phenelzine, with the formula β-phenylethylhydrazine, is a monoamine oxidase inhibiting antidepressant that is effective in the treatment of panic disorder and social anxiety disorder. It was developed by Parke Davis and originally FDA approved on June 9th, 1961. It is currently approved under prescription by the name o... | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Moderate | 1 | [
[
[
551,
24,
473
]
],
[
[
551,
6,
3486
],
[
3486,
45,
473
]
],
[
[
551,
21,
28757
],
[
28757,
60,
473
]
],
[
[
551,
64,
73
],
[
73,
... | [
[
[
"Phenelzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
]
],
[
[
"Phenelzine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)"... | Phenelzine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Repaglinide (Compound)
Phenelzine (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Repaglinide (Compound)
Phenelzine may lead to a major life threatening interaction when taken with Phentermine and Phentermine may ... |
DB12130 | DB12364 | 1,017 | 1,421 | [
"DDInter1094",
"DDInter200"
] | Lorlatinib | Betrixaban | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Moderate | 1 | [
[
[
1017,
24,
1421
]
],
[
[
1017,
63,
1091
],
[
1091,
24,
1421
]
],
[
[
1017,
64,
759
],
[
759,
24,
1421
]
],
[
[
1017,
25,
1476
],
[
1476... | [
[
[
"Lorlatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betrixaban"
]
],
[
[
"Lorlatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amprenavir"
],
[
... | Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Amprenavir and Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Lorlatinib may lead to a major life threatening interaction when taken with Primidone and Primidone may cause a ... |
DB00352 | DB01263 | 482 | 859 | [
"DDInter1814",
"DDInter1494"
] | Tioguanine | Posaconazole | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Moderate | 1 | [
[
[
482,
24,
859
]
],
[
[
482,
21,
28935
],
[
28935,
60,
859
]
],
[
[
482,
63,
1101
],
[
1101,
23,
859
]
],
[
[
482,
24,
850
],
[
850,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Posaconazole"
]
],
[
[
"Tioguanine",
"{u} (Compound) causes {v} (Side Effect)",
"Hyperbilirubinaemia"
],
[
"Hyperbilirubinaemia",
"{u}... | Tioguanine (Compound) causes Hyperbilirubinaemia (Side Effect) and Hyperbilirubinaemia (Side Effect) is caused by Posaconazole (Compound)
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects whe... |
DB06589 | DB12825 | 1,250 | 1,375 | [
"DDInter1400",
"DDInter1032"
] | Pazopanib | Lefamulin | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Major | 2 | [
[
[
1250,
25,
1375
]
],
[
[
1250,
62,
112
],
[
112,
23,
1375
]
],
[
[
1250,
24,
159
],
[
159,
63,
1375
]
],
[
[
1250,
25,
976
],
[
976,
... | [
[
[
"Pazopanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lefamulin"
]
],
[
[
"Pazopanib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidazol... | Pazopanib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lefamulin
Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Laro... |
DB00046 | DB01044 | 1,179 | 246 | [
"DDInter940",
"DDInter809"
] | Insulin lispro | Gatifloxacin | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Major | 2 | [
[
[
1179,
25,
246
]
],
[
[
1179,
25,
739
],
[
739,
1,
246
]
],
[
[
1179,
25,
945
],
[
945,
40,
246
]
],
[
[
1179,
24,
1479
],
[
1479,
... | [
[
[
"Insulin lispro",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gatifloxacin"
]
],
[
[
"Insulin lispro",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomefloxacin"
],
[
"Lomefloxacin"... | Insulin lispro may lead to a major life threatening interaction when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gatifloxacin (Compound)
Insulin lispro may lead to a major life threatening interaction when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Gatifloxacin (Compound)
Insulin li... |
DB00519 | DB01261 | 1,638 | 170 | [
"DDInter1843",
"DDInter1679"
] | Trandolapril | Sitagliptin | Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiote... | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
1638,
24,
170
]
],
[
[
1638,
21,
28850
],
[
28850,
60,
170
]
],
[
[
1638,
24,
708
],
[
708,
63,
170
]
],
[
[
1638,
63,
1179
],
[
1179,... | [
[
[
"Trandolapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Trandolapril",
"{u} (Compound) causes {v} (Side Effect)",
"Back pain"
],
[
"Back pain",
"{u} (Side Effect) is... | Trandolapril (Compound) causes Back pain (Side Effect) and Back pain (Side Effect) is caused by Sitagliptin (Compound)
Trandolapril may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin and Corticotropin may cause a moderate interaction that could exacerbate diseases when taken w... |
DB01611 | DB09293 | 1,487 | 116 | [
"DDInter893",
"DDInter954"
] | Hydroxychloroquine | Iodide I-131 | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
1487,
24,
116
]
],
[
[
1487,
64,
1493
],
[
1493,
24,
116
]
],
[
[
1487,
24,
1434
],
[
1434,
63,
116
]
],
[
[
1487,
62,
1247
],
[
1247,... | [
[
[
"Hydroxychloroquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Hydroxychloroquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Halofantrine"
],
... | Hydroxychloroquine may lead to a major life threatening interaction when taken with Halofantrine and Halofantrine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Benznidazole a... |
DB00501 | DB01224 | 752 | 623 | [
"DDInter380",
"DDInter1553"
] | Cimetidine | Quetiapine | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Minor | 0 | [
[
[
752,
23,
623
]
],
[
[
752,
63,
695
],
[
695,
1,
623
]
],
[
[
752,
24,
87
],
[
87,
1,
623
]
],
[
[
752,
23,
252
],
[
252,
1,
... | [
[
[
"Cimetidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Quetiapine"
]
],
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clozapine"
],
[
... | Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Clozapine and Clozapine (Compound) resembles Quetiapine (Compound)
Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Amoxapine and Amoxapine (Compound) resembles Quetiapine (Compound)
Cime... |
DB00543 | DB06694 | 87 | 31 | [
"DDInter82",
"DDInter1952"
] | Amoxapine | Xylometazoline (nasal) | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | Xylometazoline is an alkylbenzene. | Moderate | 1 | [
[
[
87,
24,
31
]
],
[
[
87,
6,
5214
],
[
5214,
45,
31
]
],
[
[
87,
24,
144
],
[
144,
63,
31
]
],
[
[
87,
24,
1148
],
[
1148,
24,
... | [
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Xylometazoline"
]
],
[
[
"Amoxapine",
"{u} (Compound) binds {v} (Gene)",
"ADRA1A"
],
[
"ADRA1A",
"{u} (Gene) is bound by {v} (Compound)... | Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Xylometazoline
Amoxapine (Compound) binds ADRA1A (Gene) and ADRA1A (Gene) is bound by Xylometazoline (Compound)
Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol and Olodaterol ma... |
DB06700 | DB08896 | 643 | 292 | [
"DDInter511",
"DDInter1576"
] | Desvenlafaxine | Regorafenib | Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of ad... | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Moderate | 1 | [
[
[
643,
24,
292
]
],
[
[
643,
6,
8374
],
[
8374,
45,
292
]
],
[
[
643,
21,
28890
],
[
28890,
60,
292
]
],
[
[
643,
64,
121
],
[
121,
... | [
[
[
"Desvenlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Regorafenib"
]
],
[
[
"Desvenlafaxine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Co... | Desvenlafaxine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Regorafenib (Compound)
Desvenlafaxine (Compound) causes Myocardial infarction (Side Effect) and Myocardial infarction (Side Effect) is caused by Regorafenib (Compound)
Desvenlafaxine may lead to a major life threatening interaction when taken w... |
DB00041 | DB01088 | 1,648 | 714 | [
"DDInter38",
"DDInter908"
] | Aldesleukin | Iloprost | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Moderate | 1 | [
[
[
1648,
24,
714
]
],
[
[
1648,
24,
1638
],
[
1638,
24,
714
]
],
[
[
1648,
24,
601
],
[
601,
63,
714
]
],
[
[
1648,
24,
4
],
[
4,
6... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trandolapril"
],
[
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril and Trandolapril may cause a moderate interaction that could exacerbate diseases when taken with Iloprost
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Trimethaphan and ... |
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