drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00675 | DB06699 | 888 | 774 | [
"DDInter1744",
"DDInter493"
] | Tamoxifen | Degarelix | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Moderate | 1 | [
[
[
888,
24,
774
]
],
[
[
888,
63,
521
],
[
521,
1,
774
]
],
[
[
888,
21,
29232
],
[
29232,
60,
774
]
],
[
[
888,
23,
112
],
[
112,
... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Degarelix"
]
],
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Goserelin"
],
[
... | Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin (Compound) resembles Degarelix (Compound)
Tamoxifen (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Degarelix (Compound)
Tamoxifen may cause a minor interaction that can l... |
DB00794 | DB15091 | 759 | 676 | [
"DDInter1521",
"DDInter1901"
] | Primidone | Upadacitinib | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
759,
25,
676
]
],
[
[
759,
25,
283
],
[
283,
24,
676
]
],
[
[
759,
24,
1040
],
[
1040,
24,
676
]
],
[
[
759,
63,
723
],
[
723,
2... | [
[
[
"Primidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Primidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
],
[
"Fedratinib",
"{u} m... | Primidone may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Upadacitinib
Primidone may cause a moderate interaction that could exacerbate diseases when taken with Dabrafenib and Dabrafenib may cause ... |
DB00526 | DB00991 | 1,555 | 97 | [
"DDInter1355",
"DDInter1358"
] | Oxaliplatin | Oxaprozin | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. | Moderate | 1 | [
[
[
1555,
24,
97
]
],
[
[
1555,
24,
1274
],
[
1274,
24,
97
]
],
[
[
1555,
64,
576
],
[
576,
1,
97
]
],
[
[
1555,
24,
371
],
[
371,
4... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaprozin"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
],
[... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Oxaprozin
Oxaliplatin may lead to a major life threatening interaction when taken with Methadone and Methadone (Compou... |
DB00099 | DB01206 | 440 | 37 | [
"DDInter735",
"DDInter1086"
] | Filgrastim | Lomustine | Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the seq... | An alkylating agent of value against both hematologic malignancies and solid tumors. | Moderate | 1 | [
[
[
440,
24,
37
]
],
[
[
440,
24,
147
],
[
147,
23,
37
]
],
[
[
440,
24,
141
],
[
141,
24,
37
]
],
[
[
440,
24,
385
],
[
385,
63,
... | [
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomustine"
]
],
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinblastine"
],
[
... | Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine and Vinblastine may cause a minor interaction that can limit clinical effects when taken with Lomustine
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Floxuridine and Floxur... |
DB00422 | DB09082 | 895 | 659 | [
"DDInter1189",
"DDInter1934"
] | Methylphenidate | Vilanterol | Methylphenidate is a central nervous system stimulant used most commonly in the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and for narcolepsy. Also known as the marketed products Ritalin, Concerta, or Biphentin, methylphenidate is used with other treatment modalities (psychological, educational, cogni... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
895,
24,
659
]
],
[
[
895,
24,
1264
],
[
1264,
24,
659
]
],
[
[
895,
63,
1636
],
[
1636,
24,
659
]
],
[
[
895,
25,
1053
],
[
1053,
... | [
[
[
"Methylphenidate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Methylphenidate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
... | Methylphenidate may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol
Methylphenidate may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine and... |
DB06772 | DB11952 | 310 | 800 | [
"DDInter259",
"DDInter612"
] | Cabazitaxel | Duvelisib | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Moderate | 1 | [
[
[
310,
24,
800
]
],
[
[
310,
63,
467
],
[
467,
24,
800
]
],
[
[
310,
24,
1476
],
[
1476,
63,
800
]
],
[
[
310,
24,
578
],
[
578,
2... | [
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
]
],
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Simvastatin"
],
[
... | Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib
Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Bri... |
DB00400 | DB09049 | 353 | 1,135 | [
"DDInter843",
"DDInter1261"
] | Griseofulvin | Naloxegol | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Naloxegol, for "PEGylated naloxol" is a peripherally-selective opioid antagonist developed by AstraZeneca. It was approved by the FDA in September 2014 and is indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non‑cancer pain. The advantage of naloxegol over the opioid antag... | Moderate | 1 | [
[
[
353,
24,
1135
]
],
[
[
353,
24,
807
],
[
807,
23,
1135
]
],
[
[
353,
24,
971
],
[
971,
62,
1135
]
],
[
[
353,
63,
79
],
[
79,
23... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
]
],
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ulipristal"
],
[... | Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Ulipristal and Ulipristal may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib and Gil... |
DB00283 | DB00470 | 701 | 530 | [
"DDInter395",
"DDInter601"
] | Clemastine | Dronabinol | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Moderate | 1 | [
[
[
701,
24,
530
]
],
[
[
701,
24,
1614
],
[
1614,
40,
530
]
],
[
[
701,
6,
8374
],
[
8374,
45,
530
]
],
[
[
701,
21,
29118
],
[
29118,
... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
],
[
... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabilone (Compound) resembles Dronabinol (Compound)
Clemastine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dronabinol (Compound)
Clemastine (Compound) causes Tachycardia (Side Effect) and Tachycardia... |
DB00250 | DB15093 | 10 | 1,654 | [
"DDInter475",
"DDInter1698"
] | Dapsone | Somapacitan | A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of m... | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
10,
24,
1654
]
],
[
[
10,
63,
168
],
[
168,
23,
1654
]
],
[
[
10,
24,
351
],
[
351,
24,
1654
]
],
[
[
10,
63,
1324
],
[
1324,
24... | [
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
"... | Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Somapacitan
Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Ribociclib ma... |
DB00059 | DB01278 | 1,560 | 1,021 | [
"DDInter1404",
"DDInter1506"
] | Pegaspargase | Pramlintide | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Moderate | 1 | [
[
[
1560,
24,
1021
]
],
[
[
1560,
24,
1142
],
[
1142,
24,
1021
]
],
[
[
1560,
24,
1019
],
[
1019,
63,
1021
]
],
[
[
1560,
63,
1685
],
[
16... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pramlintide"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orlistat"
],
[... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Orlistat and Orlistat may cause a moderate interaction that could exacerbate diseases when taken with Pramlintide
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort and Defl... |
DB00563 | DB00987 | 663 | 1,224 | [
"DDInter1174",
"DDInter460"
] | Methotrexate | Cytarabine | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant p... | Moderate | 1 | [
[
[
663,
24,
1224
]
],
[
[
663,
5,
11555
],
[
11555,
44,
1224
]
],
[
[
663,
6,
14544
],
[
14544,
45,
1224
]
],
[
[
663,
7,
7720
],
[
7720,... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cytarabine"
]
],
[
[
"Methotrexate",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Di... | Methotrexate (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Cytarabine (Compound)
Methotrexate (Compound) binds ABCC10 (Gene) and ABCC10 (Gene) is bound by Cytarabine (Compound)
Methotrexate (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Cytarabine ... |
DB01244 | DB13142 | 762 | 841 | [
"DDInter192",
"DDInter274"
] | Bepridil | Calcium glubionate anhydrous | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Calcium glubionate (or glubionate calcium) is a mineral supplement to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets. | Moderate | 1 | [
[
[
762,
24,
841
]
],
[
[
762,
63,
1053
],
[
1053,
23,
255
],
[
255,
24,
841
]
],
[
[
762,
64,
77
],
[
77,
23,
255
],
[
255,
24,
8... | [
[
[
"Bepridil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium glubionate anhydrous"
]
],
[
[
"Bepridil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"... | Bepridil may cause a moderate interaction that could exacerbate diseases when taken with Procarbazine and Procarbazine may cause a minor interaction that can limit clinical effects when taken with Delafloxacin and Delafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Calcium glubi... |
DB00418 | DB00762 | 536 | 613 | [
"DDInter1650",
"DDInter973"
] | Secobarbital | Irinotecan | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Moderate | 1 | [
[
[
536,
24,
613
]
],
[
[
536,
21,
28658
],
[
28658,
60,
613
]
],
[
[
536,
24,
927
],
[
927,
63,
613
]
],
[
[
536,
23,
752
],
[
752,
... | [
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Irinotecan"
]
],
[
[
"Secobarbital",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Effect) is ca... | Secobarbital (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Irinotecan (Compound)
Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Iri... |
DB00078 | DB15035 | 1,172 | 503 | [
"DDInter898",
"DDInter1959"
] | Ibritumomab tiuxetan | Zanubrutinib | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Major | 2 | [
[
[
1172,
25,
503
]
],
[
[
1172,
24,
222
],
[
222,
24,
503
]
],
[
[
1172,
63,
1257
],
[
1257,
24,
503
]
],
[
[
1172,
25,
676
],
[
676,
... | [
[
[
"Ibritumomab tiuxetan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
... | Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00390 | DB11828 | 1,252 | 1,406 | [
"DDInter554",
"DDInter1281"
] | Digoxin | Neratinib | Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also known as the _Digi... | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Moderate | 1 | [
[
[
1252,
24,
1406
]
],
[
[
1252,
25,
392
],
[
392,
24,
1406
]
],
[
[
1252,
23,
1475
],
[
1475,
24,
1406
]
],
[
[
1252,
24,
1456
],
[
1456... | [
[
[
"Digoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Neratinib"
]
],
[
[
"Digoxin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lapatinib"
],
[
"Lapatinib",
... | Digoxin may lead to a major life threatening interaction when taken with Lapatinib and Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Neratinib
Digoxin may cause a minor interaction that can limit clinical effects when taken with Sodium citrate and Sodium citrate may cause a m... |
DB10343 | DB12001 | 962 | 564 | [
"DDInter160",
"DDInter7"
] | Bacillus calmette-guerin substrain tice live antigen | Abemaciclib | Bacillus calmette-guerin substrain tice live antigen is a vaccine containing attenuated live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of *Mycobacterium bovis* for percutaneous use. It is administered to prevent the development of tuberculosis. | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Major | 2 | [
[
[
962,
25,
564
]
],
[
[
962,
64,
58
],
[
58,
24,
564
]
],
[
[
962,
25,
351
],
[
351,
24,
564
]
],
[
[
962,
25,
1476
],
[
1476,
63,... | [
[
[
"Bacillus calmette-guerin substrain tice live antigen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Abemaciclib"
]
],
[
[
"Bacillus calmette-guerin substrain tice live antigen",
"{u} may lead to a major life threatening interaction w... | Bacillus calmette-guerin substrain tice live antigen may lead to a major life threatening interaction when taken with Alefacept and Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Bacillus calmette-guerin substrain tice live antigen may lead to a major life threaten... |
DB00427 | DB00842 | 1,233 | 686 | [
"DDInter1879",
"DDInter1359"
] | Triprolidine | Oxazepam | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Oxazepam is an intermediate-acting, 3-hydroxybenzodiazepine used in the treatment of alcohol withdrawal and anxiety disorders. Oxazepam, like related 3-hydroxybenzodiazepine [lorazepam], is considered less susceptible to pharmacokinetic variability based on patient-specific factors (e.g. age, liver disease) - this feat... | Moderate | 1 | [
[
[
1233,
24,
686
]
],
[
[
1233,
63,
695
],
[
695,
40,
686
]
],
[
[
1233,
24,
1563
],
[
1563,
40,
686
]
],
[
[
1233,
24,
1119
],
[
1119,
... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxazepam"
]
],
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clozapine"
],
[
... | Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Clozapine and Clozapine (Compound) resembles Oxazepam (Compound)
Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Halazepam and Halazepam (Compound) resembles Oxazepam (Compound)
Trip... |
DB00414 | DB13007 | 590 | 1,060 | [
"DDInter16",
"DDInter642"
] | Acetohexamide | Enfortumab vedotin | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Enfortumab vedotin is an antibody-drug conjugate used in the treatment of patients with advanced, treatment-resistant urothelial cancers. It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting chemotherapeutic agent, monomethyl auristatin E (MMAE), joined by a protea... | Moderate | 1 | [
[
[
590,
24,
1060
]
],
[
[
590,
24,
1604
],
[
1604,
23,
1060
]
],
[
[
590,
24,
1281
],
[
1281,
24,
1060
]
],
[
[
590,
63,
1645
],
[
1645,
... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enfortumab vedotin"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lumacaftor"
... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Lumacaftor and Lumacaftor may cause a minor interaction that can limit clinical effects when taken with Enfortumab vedotin
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Linaglipt... |
DB00443 | DB00562 | 251 | 1,014 | [
"DDInter195",
"DDInter188"
] | Betamethasone | Benzthiazide | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used... | Moderate | 1 | [
[
[
251,
24,
1014
]
],
[
[
251,
24,
811
],
[
811,
40,
1014
]
],
[
[
251,
24,
674
],
[
674,
1,
1014
]
],
[
[
251,
63,
323
],
[
323,
4... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzthiazide"
]
],
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metolazone"
],
... | Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Metolazone and Metolazone (Compound) resembles Benzthiazide (Compound)
Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Trichlormethiazide and Trichlormethiazide (Compound) resemble... |
DB01149 | DB09030 | 851 | 840 | [
"DDInter1274",
"DDInter1945"
] | Nefazodone | Vorapaxar | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expr... | Major | 2 | [
[
[
851,
25,
840
]
],
[
[
851,
24,
885
],
[
885,
24,
840
]
],
[
[
851,
63,
714
],
[
714,
24,
840
]
],
[
[
851,
25,
1017
],
[
1017,
6... | [
[
[
"Nefazodone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vorapaxar"
]
],
[
[
"Nefazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
],
[
"Epoproste... | Nefazodone may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Vorapaxar
Nefazodone may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Ilopr... |
DB00046 | DB00288 | 1,179 | 1,103 | [
"DDInter940",
"DDInter63"
] | Insulin lispro | Amcinonide | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Amcinonide is a corticosteroid. | Minor | 0 | [
[
[
1179,
23,
1103
]
],
[
[
1179,
24,
175
],
[
175,
40,
1103
]
],
[
[
1179,
24,
870
],
[
870,
1,
1103
]
],
[
[
1179,
24,
5
],
[
5,
6... | [
[
[
"Insulin lispro",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Amcinonide (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resemble... |
DB00342 | DB01232 | 1,181 | 1,327 | [
"DDInter1770",
"DDInter1640"
] | Terfenadine | Saquinavir | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Major | 2 | [
[
[
1181,
25,
1327
]
],
[
[
1181,
64,
798
],
[
798,
40,
1327
]
],
[
[
1181,
25,
915
],
[
915,
40,
1327
]
],
[
[
1181,
23,
112
],
[
112,
... | [
[
[
"Terfenadine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Saquinavir"
]
],
[
[
"Terfenadine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nelfinavir"
],
[
"Nelfinavir",
"{u}... | Terfenadine may lead to a major life threatening interaction when taken with Nelfinavir and Nelfinavir (Compound) resembles Saquinavir (Compound)
Terfenadine may lead to a major life threatening interaction when taken with Atazanavir and Atazanavir (Compound) resembles Saquinavir (Compound)
Terfenadine may cause a mino... |
DB00495 | DB04845 | 139 | 309 | [
"DDInter1961",
"DDInter1001"
] | Zidovudine | Ixabepilone | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain... | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Moderate | 1 | [
[
[
139,
24,
309
]
],
[
[
139,
6,
8374
],
[
8374,
45,
309
]
],
[
[
139,
21,
28987
],
[
28987,
60,
309
]
],
[
[
139,
24,
60
],
[
60,
... | [
[
[
"Zidovudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
]
],
[
[
"Zidovudine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Zidovudine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ixabepilone (Compound)
Zidovudine (Compound) causes Chills (Side Effect) and Chills (Side Effect) is caused by Ixabepilone (Compound)
Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Capecitabine and Capeci... |
DB06043 | DB06168 | 1,644 | 1,531 | [
"DDInter1328",
"DDInter281"
] | Olaratumab | Canakinumab | Olaratumab (IMC-3G3) is a fully human IgG1 monoclonal antibody with antitumor activity that selectively binds the external domain of human platelet-derived growth factor receptor (PDGFR)-α with high affinity and blocks ligand binding. It is composed of two heavy chain molecule fragments and 2 light chain fragments. Stu... | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Moderate | 1 | [
[
[
1644,
24,
1531
]
],
[
[
1644,
24,
1270
],
[
1270,
63,
1531
]
],
[
[
1644,
63,
599
],
[
599,
24,
1531
]
],
[
[
1644,
64,
1066
],
[
1066... | [
[
[
"Olaratumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
]
],
[
[
"Olaratumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protei... | Olaratumab may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative and Tuberculin purified protein derivative may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab
Olaratumab may cause a moderate interaction that could ... |
DB00575 | DB11827 | 1,020 | 433 | [
"DDInter412",
"DDInter669"
] | Clonidine | Ertugliflozin | Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors. This activity is useful for the treatment of hypertension, severe pain, and ADHD.[L7237,L7240,L7243,L7246] Clonidine was granted FDA approval on 3 September 1974. | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
1020,
24,
433
]
],
[
[
1020,
24,
959
],
[
959,
24,
433
]
],
[
[
1020,
63,
251
],
[
251,
24,
433
]
],
[
[
1020,
1,
1084
],
[
1084,
... | [
[
[
"Clonidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Clonidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Clonidine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Clonidine may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Beta... |
DB00295 | DB00315 | 475 | 767 | [
"DDInter1244",
"DDInter1969"
] | Morphine | Zolmitriptan | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Zolmitriptan is a member of the triptan class of 5-hydroxytryptamine(5-HT)<sub>1B/1D/(1F)</sub> receptor agonists used to treat acute migraine.[A462, L12978] [Sumatriptan] was the first triptan to be developed, but had poor oral bioavailability and lipophilicity. This led to the development of second-generation triptan... | Moderate | 1 | [
[
[
475,
24,
767
]
],
[
[
475,
24,
1373
],
[
1373,
40,
767
]
],
[
[
475,
21,
28876
],
[
28876,
60,
767
]
],
[
[
475,
24,
752
],
[
752,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zolmitriptan"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Almotriptan"
],
[
... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Almotriptan and Almotriptan (Compound) resembles Zolmitriptan (Compound)
Morphine (Compound) causes Anaphylactoid reaction (Side Effect) and Anaphylactoid reaction (Side Effect) is caused by Zolmitriptan (Compound)
Morphine may cau... |
DB08912 | DB12941 | 1,040 | 466 | [
"DDInter462",
"DDInter481"
] | Dabrafenib | Darolutamide | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen receptor antagonists. Though prior treatment for prostate canc... | Moderate | 1 | [
[
[
1040,
24,
466
]
],
[
[
1040,
63,
1622
],
[
1622,
23,
466
]
],
[
[
1040,
24,
351
],
[
351,
23,
466
]
],
[
[
1040,
25,
283
],
[
283,
... | [
[
[
"Dabrafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
]
],
[
[
"Dabrafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Voriconazole"
],
... | Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Voriconazole and Voriconazole may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Ri... |
DB01045 | DB09291 | 463 | 741 | [
"DDInter1590",
"DDInter1615"
] | Rifampicin | Rolapitant | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Rolapitant is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and vomiting (CINV) in adults. Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated by Neurokinin-1 and its l... | Major | 2 | [
[
[
463,
25,
741
]
],
[
[
463,
25,
1135
],
[
1135,
23,
741
]
],
[
[
463,
25,
159
],
[
159,
63,
741
]
],
[
[
463,
25,
1496
],
[
1496,
... | [
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rolapitant"
]
],
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} may... | Rifampicin may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Rolapitant
Rifampicin may lead to a major life threatening interaction when taken with Larotrectinib and Larotrectinib may cause a moderate in... |
DB00773 | DB09074 | 896 | 1,362 | [
"DDInter702",
"DDInter1327"
] | Etoposide | Olaparib | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
896,
24,
1362
]
],
[
[
896,
24,
1683
],
[
1683,
24,
1362
]
],
[
[
896,
63,
139
],
[
139,
24,
1362
]
],
[
[
896,
24,
385
],
[
385,
... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
],
[
... | Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine and Zidovudi... |
DB00700 | DB00877 | 312 | 629 | [
"DDInter656",
"DDInter1678"
] | Eplerenone | Sirolimus | Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone c... | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Moderate | 1 | [
[
[
312,
24,
629
]
],
[
[
312,
6,
21998
],
[
21998,
45,
629
]
],
[
[
312,
18,
6718
],
[
6718,
57,
629
]
],
[
[
312,
21,
29203
],
[
29203,
... | [
[
[
"Eplerenone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
]
],
[
[
"Eplerenone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A7-CYP3A51P"
],
[
"CYP3A7-CYP3A51P",
"{u} (Gene) is bound by... | Eplerenone (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Sirolimus (Compound)
Eplerenone (Compound) downregulates USP22 (Gene) and USP22 (Gene) is downregulated by Sirolimus (Compound)
Eplerenone (Compound) causes Aspartate aminotransferase increased (Side Effect) and Aspartate aminotra... |
DB00999 | DB09080 | 504 | 144 | [
"DDInter883",
"DDInter1331"
] | Hydrochlorothiazide | Olodaterol | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
504,
24,
144
]
],
[
[
504,
63,
11
],
[
11,
24,
144
]
],
[
[
504,
25,
57
],
[
57,
24,
144
]
],
[
[
504,
62,
600
],
[
600,
24,
... | [
[
[
"Hydrochlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Hydrochlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Toremifen... | Hydrochlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Toremifene and Toremifene may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Hydrochlorothiazide may lead to a major life threatening interaction when taken with Arsenic trioxide a... |
DB05528 | DB12500 | 1,070 | 283 | [
"DDInter1228",
"DDInter714"
] | Mipomersen | Fedratinib | Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. M... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Major | 2 | [
[
[
1070,
25,
283
]
],
[
[
1070,
25,
351
],
[
351,
23,
283
]
],
[
[
1070,
64,
1419
],
[
1419,
24,
283
]
],
[
[
1070,
25,
971
],
[
971,
... | [
[
[
"Mipomersen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
]
],
[
[
"Mipomersen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
],
[
"Ribociclib",
"{u} m... | Mipomersen may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Mipomersen may lead to a major life threatening interaction when taken with Imatinib and Imatinib may cause a moderate interactio... |
DB00656 | DB01142 | 827 | 1,264 | [
"DDInter1851",
"DDInter593"
] | Trazodone | Doxepin | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Major | 2 | [
[
[
827,
25,
1264
]
],
[
[
827,
24,
401
],
[
401,
24,
1264
]
],
[
[
827,
63,
1594
],
[
1594,
24,
1264
]
],
[
[
827,
24,
649
],
[
649,
... | [
[
[
"Trazodone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Doxepin"
]
],
[
[
"Trazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
"Promethazine"... | Trazodone may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Trazodone may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylam... |
DB00685 | DB09322 | 1,299 | 1,114 | [
"DDInter1887",
"DDInter1966"
] | Trovafloxacin | Zinc sulfate | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Zinc sulfate is the inorganic compound with the formula ZnSO4 and historically known as "white vitriol". It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system. | Moderate | 1 | [
[
[
1299,
24,
1114
]
],
[
[
1299,
64,
251
],
[
251,
23,
1114
]
],
[
[
1299,
23,
1307
],
[
1307,
23,
1114
]
],
[
[
1299,
25,
891
],
[
891,
... | [
[
[
"Trovafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc sulfate"
]
],
[
[
"Trovafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betamethasone"
],
[
... | Trovafloxacin may lead to a major life threatening interaction when taken with Betamethasone and Betamethasone may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate
Trovafloxacin may cause a minor interaction that can limit clinical effects when taken with Melphalan and Melphalan ma... |
DB00601 | DB01114 | 453 | 272 | [
"DDInter1073",
"DDInter362"
] | Linezolid | Chlorpheniramine | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Moderate | 1 | [
[
[
453,
24,
272
]
],
[
[
453,
24,
849
],
[
849,
63,
272
]
],
[
[
453,
63,
128
],
[
128,
24,
272
]
],
[
[
453,
21,
28898
],
[
28898,
... | [
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
]
],
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
... | Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramin... |
DB00242 | DB11760 | 1,064 | 119 | [
"DDInter392",
"DDInter1742"
] | Cladribine | Talazoparib | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 and by the EMA in June 2019. It was app... | Major | 2 | [
[
[
1064,
25,
119
]
],
[
[
1064,
64,
66
],
[
66,
24,
119
]
],
[
[
1064,
24,
1129
],
[
1129,
63,
119
]
],
[
[
1064,
25,
713
],
[
713,
... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Talazoparib"
]
],
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Efalizumab"
],
[
"Efalizumab",
"{u} ... | Cladribine may lead to a major life threatening interaction when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Talazoparib
Cladribine may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strai... |
DB00738 | DB12141 | 485 | 971 | [
"DDInter1420",
"DDInter817"
] | Pentamidine | Gilteritinib | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
485,
24,
971
]
],
[
[
485,
23,
1247
],
[
1247,
23,
971
]
],
[
[
485,
24,
730
],
[
730,
63,
971
]
],
[
[
485,
63,
1100
],
[
1100,
... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Pentamidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Pentamidine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Deutetrab... |
DB01169 | DB01211 | 57 | 609 | [
"DDInter120",
"DDInter393"
] | Arsenic trioxide | Clarithromycin | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Major | 2 | [
[
[
57,
25,
609
]
],
[
[
57,
64,
1570
],
[
1570,
24,
609
]
],
[
[
57,
6,
4973
],
[
4973,
45,
609
]
],
[
[
57,
64,
600
],
[
600,
23,
... | [
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
]
],
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Azithromycin"
],
[
"Azithro... | Arsenic trioxide may lead to a major life threatening interaction when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Arsenic trioxide (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clarithromycin (Compound)
Arsenic tri... |
DB12332 | DB14444 | 1,619 | 151 | [
"DDInter1626",
"DDInter924"
] | Rucaparib | Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immuno... | Moderate | 1 | [
[
[
1619,
24,
151
]
],
[
[
1619,
63,
66
],
[
66,
24,
151
]
],
[
[
1619,
64,
375
],
[
375,
24,
151
]
],
[
[
1619,
25,
676
],
[
676,
6... | [
[
[
"Rucaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)"
]
],
[
[
"Rucaparib",
"{u} may cause a moderate interaction that could exa... | Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Rucaparib may lead to a major life thr... |
DB00001 | DB08816 | 1,578 | 578 | [
"DDInter1037",
"DDInter1802"
] | Lepirudin | Ticagrelor | Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor.[L41539,L41569] Natural hirudin is an endogenous anticoagulant found in _Hirudo medicinalis_ leeches. Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence o... | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
1578,
24,
578
]
],
[
[
1578,
23,
297
],
[
297,
62,
578
]
],
[
[
1578,
25,
1172
],
[
1172,
24,
578
]
],
[
[
1578,
24,
1039
],
[
1039,
... | [
[
[
"Lepirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Lepirudin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clov... | Lepirudin may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Ticagrelor
Lepirudin may lead to a major life threatening interaction when taken with Ibritumomab tiuxetan and Ibritumomab tiuxetan may ca... |
DB01377 | DB12147 | 1,283 | 241 | [
"DDInter1119",
"DDInter661"
] | Magnesium oxide | Erdafitinib | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | In early April of 2019, the US FDA approved Janssen Pharmaceutical Companies' brand name Balversa (erdafitinib) as the first-ever fibroblast growth factor receptor (FGFR) kinase inhibitor indicated for patients with locally advanced or metastatic urothelial carcinoma, with susceptible FGFR3 or FGFR2 genetic alterations... | Major | 2 | [
[
[
1283,
25,
241
]
],
[
[
1283,
24,
478
],
[
478,
24,
241
]
],
[
[
1283,
63,
1195
],
[
1195,
24,
241
]
],
[
[
1283,
24,
286
],
[
286,
... | [
[
[
"Magnesium oxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Erdafitinib"
]
],
[
[
"Magnesium oxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
"... | Magnesium oxide may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Erdafitinib
Magnesium oxide may cause a moderate interaction that could exacerbate diseases when taken with Erlotinib an... |
DB00374 | DB09280 | 1,061 | 1,604 | [
"DDInter1852",
"DDInter1101"
] | Treprostinil | Lumacaftor | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Moderate | 1 | [
[
[
1061,
24,
1604
]
],
[
[
1061,
24,
1171
],
[
1171,
24,
1604
]
],
[
[
1061,
25,
292
],
[
292,
24,
1604
]
],
[
[
1061,
63,
1230
],
[
1230... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lumacaftor"
]
],
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meloxicam"
],
[... | Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Meloxicam and Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Lumacaftor
Treprostinil may lead to a major life threatening interaction when taken with Regorafenib and Regorafenib may ca... |
DB00530 | DB00745 | 1,195 | 307 | [
"DDInter667",
"DDInter1236"
] | Erlotinib | Modafinil | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Minor | 0 | [
[
[
1195,
23,
307
]
],
[
[
1195,
63,
362
],
[
362,
40,
307
]
],
[
[
1195,
24,
1236
],
[
1236,
40,
307
]
],
[
[
1195,
6,
7950
],
[
7950,
... | [
[
[
"Erlotinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
]
],
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
[
"P... | Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Modafinil (Compound)
Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Carbamazepine and Carbamazepine (Compound) resembles Modafinil (Compound)
... |
DB06176 | DB06603 | 1,342 | 39 | [
"DDInter1616",
"DDInter1387"
] | Romidepsin | Panobinostat | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
1342,
25,
39
]
],
[
[
1342,
62,
1247
],
[
1247,
23,
39
]
],
[
[
1342,
63,
479
],
[
479,
23,
39
]
],
[
[
1342,
63,
1257
],
[
1257,
... | [
[
[
"Romidepsin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Romidepsin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"Sulf... | Romidepsin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Donepezil a... |
DB00990 | DB01138 | 1,547 | 804 | [
"DDInter705",
"DDInter1726"
] | Exemestane | Sulfinpyrazone | Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It irreversibly binds to the active site of the enzyme resulting in permanent inhibition. | A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties. | Moderate | 1 | [
[
[
1547,
24,
804
]
],
[
[
1547,
63,
998
],
[
998,
1,
804
]
],
[
[
1547,
6,
8374
],
[
8374,
45,
804
]
],
[
[
1547,
63,
1101
],
[
1101,
... | [
[
[
"Exemestane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfinpyrazone"
]
],
[
[
"Exemestane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylbutazone"
],
... | Exemestane may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutazone and Phenylbutazone (Compound) resembles Sulfinpyrazone (Compound)
Exemestane (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sulfinpyrazone (Compound)
Exemestane may cause a moderate interaction that c... |
DB01001 | DB01364 | 688 | 22 | [
"DDInter1632",
"DDInter650"
] | Salbutamol | Ephedrine | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Moderate | 1 | [
[
[
688,
24,
22
]
],
[
[
688,
63,
80
],
[
80,
24,
22
]
],
[
[
688,
24,
1529
],
[
1529,
63,
22
]
],
[
[
688,
24,
280
],
[
280,
1,
... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ephedrine"
]
],
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amphetamine"
],
[
... | Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Amphetamine and Amphetamine may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine
Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Metamfetamine and Me... |
DB00295 | DB00986 | 475 | 1,192 | [
"DDInter1244",
"DDInter834"
] | Morphine | Glycopyrronium | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | Moderate | 1 | [
[
[
475,
24,
1192
]
],
[
[
475,
24,
1511
],
[
1511,
63,
1192
]
],
[
[
475,
24,
262
],
[
262,
24,
1192
]
],
[
[
475,
21,
29180
],
[
29180,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glycopyrronium"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
[
... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Clidinium and Clidi... |
DB01220 | DB11718 | 1,088 | 927 | [
"DDInter1593",
"DDInter640"
] | Rifaximin | Encorafenib | Rifaximin is a semisynthetic, rifamycin-based non-systemic antibiotic, meaning that the drug will not pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics. It has multiple indications and is used in treatment of traveller's diarrhea caused by E. coli; reduc... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
1088,
24,
927
]
],
[
[
1088,
24,
165
],
[
165,
24,
927
]
],
[
[
1088,
24,
484
],
[
484,
63,
927
]
],
[
[
1088,
63,
79
],
[
79,
2... | [
[
[
"Rifaximin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Rifaximin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolvaptan"
],
[
... | Rifaximin may cause a moderate interaction that could exacerbate diseases when taken with Tolvaptan and Tolvaptan may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Rifaximin may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and Entrecti... |
DB00619 | DB08820 | 1,419 | 1,478 | [
"DDInter909",
"DDInter997"
] | Imatinib | Ivacaftor | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Major | 2 | [
[
[
1419,
25,
1478
]
],
[
[
1419,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
1419,
21,
30495
],
[
30495,
60,
1478
]
],
[
[
1419,
23,
907
],
[
90... | [
[
[
"Imatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivacaftor"
]
],
[
[
"Imatinib",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Ivacaftor"
... | Imatinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Imatinib (Compound) causes Pleuritic pain (Side Effect) and Pleuritic pain (Side Effect) is caused by Ivacaftor (Compound)
Imatinib may cause a minor interaction that can limit clinical effects when taken with Doravirine and Dora... |
DB00622 | DB00945 | 1,081 | 1,479 | [
"DDInter1287",
"DDInter20"
] | Nicardipine | Acetylsalicylic acid | A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [Pub... | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Moderate | 1 | [
[
[
1081,
24,
1479
]
],
[
[
1081,
6,
10215
],
[
10215,
45,
1479
]
],
[
[
1081,
21,
29250
],
[
29250,
60,
1479
]
],
[
[
1081,
40,
409
],
[
... | [
[
[
"Nicardipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
]
],
[
[
"Nicardipine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v... | Nicardipine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Acetylsalicylic acid (Compound)
Nicardipine (Compound) causes Polyuria (Side Effect) and Polyuria (Side Effect) is caused by Acetylsalicylic acid (Compound)
Nicardipine (Compound) resembles Felodipine (Compound) and Felodipine may cause a modera... |
DB00872 | DB01234 | 1,080 | 1,220 | [
"DDInter438",
"DDInter513"
] | Conivaptan | Dexamethasone | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
1080,
24,
1220
]
],
[
[
1080,
63,
870
],
[
870,
1,
1220
]
],
[
[
1080,
64,
175
],
[
175,
40,
1220
]
],
[
[
1080,
25,
617
],
[
617,
... | [
[
[
"Conivaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Conivaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
],
... | Conivaptan may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Conivaptan may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone (Compound) resembles Dexamethasone (Com... |
DB00015 | DB00775 | 582 | 1,226 | [
"DDInter1585",
"DDInter1818"
] | Reteplase | Tirofiban | Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids p... | Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation. | Major | 2 | [
[
[
582,
25,
1226
]
],
[
[
582,
23,
539
],
[
539,
62,
1226
]
],
[
[
582,
24,
714
],
[
714,
63,
1226
]
],
[
[
582,
24,
940
],
[
940,
... | [
[
[
"Reteplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tirofiban"
]
],
[
[
"Reteplase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsicum",
... | Reteplase may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Tirofiban
Reteplase may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may cause ... |
DB00092 | DB00290 | 58 | 329 | [
"DDInter40",
"DDInter219"
] | Alefacept | Bleomycin | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | A complex of related glycopeptide antibiotics from <i>Streptomyces verticillus</i> consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin. | Moderate | 1 | [
[
[
58,
24,
329
]
],
[
[
58,
24,
372
],
[
372,
63,
329
]
],
[
[
58,
24,
362
],
[
362,
24,
329
]
],
[
[
58,
63,
1184
],
[
1184,
24,
... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bleomycin"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
],
[
... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Bleomycin
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoi... |
DB00563 | DB00681 | 663 | 1,287 | [
"DDInter1174",
"DDInter85"
] | Methotrexate | Amphotericin B | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphot... | Moderate | 1 | [
[
[
663,
24,
1287
]
],
[
[
663,
21,
28930
],
[
28930,
60,
1287
]
],
[
[
663,
24,
1622
],
[
1622,
23,
1287
]
],
[
[
663,
63,
600
],
[
600,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amphotericin B"
]
],
[
[
"Methotrexate",
"{u} (Compound) causes {v} (Side Effect)",
"Depressed level of consciousness"
],
[
"Depressed lev... | Methotrexate (Compound) causes Depressed level of consciousness (Side Effect) and Depressed level of consciousness (Side Effect) is caused by Amphotericin B (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Voriconazole and Voriconazole may cause a minor interaction... |
DB00697 | DB04837 | 876 | 649 | [
"DDInter1821",
"DDInter407"
] | Tizanidine | Clofedanol | Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury. It may also be caused by musculoskeletal injury. Regardless of the cause, muscle spasticity can be an extremely painful and debili... | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
876,
24,
649
]
],
[
[
876,
24,
1376
],
[
1376,
24,
649
]
],
[
[
876,
24,
832
],
[
832,
40,
649
]
],
[
[
876,
63,
701
],
[
701,
2... | [
[
[
"Tizanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Tizanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
... | Tizanidine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Tizanidine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennam... |
DB00055 | DB00975 | 834 | 1,317 | [
"DDInter605",
"DDInter573"
] | Drotrecogin alfa | Dipyridamole | Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated th... | A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752) | Major | 2 | [
[
[
834,
25,
1317
]
],
[
[
834,
23,
944
],
[
944,
62,
1317
]
],
[
[
834,
25,
1496
],
[
1496,
63,
1317
]
],
[
[
834,
24,
318
],
[
318,
... | [
[
[
"Drotrecogin alfa",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dipyridamole"
]
],
[
[
"Drotrecogin alfa",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
... | Drotrecogin alfa may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Dipyridamole
Drotrecogin alfa may lead to a major life threatening interaction when taken with Nintedanib and Nintedanib ma... |
DB01211 | DB09472 | 609 | 1,383 | [
"DDInter393",
"DDInter1693"
] | Clarithromycin | Sodium sulfate | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
609,
24,
1383
]
],
[
[
609,
24,
1482
],
[
1482,
23,
1383
]
],
[
[
609,
64,
1252
],
[
1252,
23,
1383
]
],
[
[
609,
63,
521
],
[
521,
... | [
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digitoxin"
... | Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Digitoxin and Digitoxin may cause a minor interaction that can limit clinical effects when taken with Sodium sulfate
Clarithromycin may lead to a major life threatening interaction when taken with Digoxin and Digoxin may caus... |
DB00501 | DB00598 | 752 | 1,523 | [
"DDInter380",
"DDInter1013"
] | Cimetidine | Labetalol | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture. Labetalol is formulated as an injection or tablets to treat hypertension.[L7727,L7730] Labetalol was granted FDA approval on 1 August 1984. | Moderate | 1 | [
[
[
752,
24,
1523
]
],
[
[
752,
24,
532
],
[
532,
1,
1523
]
],
[
[
752,
23,
935
],
[
935,
1,
1523
]
],
[
[
752,
23,
1274
],
[
1274,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Labetalol"
]
],
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dobutamine"
],
[
... | Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Dobutamine and Dobutamine (Compound) resembles Labetalol (Compound)
Cimetidine may cause a minor interaction that can limit clinical effects when taken with Ketoprofen and Ketoprofen (Compound) resembles Labetalol (Compound)
Cime... |
DB00275 | DB00959 | 217 | 1,486 | [
"DDInter1330",
"DDInter1191"
] | Olmesartan | Methylprednisolone | Olmesartan belongs to the angiotensin II receptor blocker (ARB) family of drugs, which also includes [telmisartan], [candesartan], [losartan], [valsartan], and [irbesartan]. ARBs selectively bind to angiotensin receptor 1 (AT1) and prevent the protein angiotensin II from binding and exerting its hypertensive effects, w... | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Moderate | 1 | [
[
[
217,
24,
1486
]
],
[
[
217,
24,
175
],
[
175,
40,
1486
]
],
[
[
217,
24,
167
],
[
167,
1,
1486
]
],
[
[
217,
21,
28997
],
[
28997,
... | [
[
[
"Olmesartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Olmesartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
... | Olmesartan may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Olmesartan may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles ... |
DB00490 | DB01612 | 946 | 1,637 | [
"DDInter254",
"DDInter92"
] | Buspirone | Amyl Nitrite | Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class, buspirone is a serotonin 5-HT<sub>1A</sub> receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic dr... | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Moderate | 1 | [
[
[
946,
24,
1637
]
],
[
[
946,
64,
475
],
[
475,
24,
1637
]
],
[
[
946,
24,
401
],
[
401,
24,
1637
]
],
[
[
946,
25,
1053
],
[
1053,
... | [
[
[
"Buspirone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Buspirone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Morphine"
],
[
"Morphine",
... | Buspirone may lead to a major life threatening interaction when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Buspirone may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause ... |
DB00041 | DB00675 | 1,648 | 888 | [
"DDInter38",
"DDInter1744"
] | Aldesleukin | Tamoxifen | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Moderate | 1 | [
[
[
1648,
24,
888
]
],
[
[
1648,
24,
675
],
[
675,
25,
888
]
],
[
[
1648,
24,
358
],
[
358,
40,
888
]
],
[
[
1648,
24,
1376
],
[
1376,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tamoxifen"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextropropoxyphene"
],... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Dextropropoxyphene and Dextropropoxyphene may lead to a major life threatening interaction when taken with Tamoxifen
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Or... |
DB00106 | DB01238 | 618 | 673 | [
"DDInter4",
"DDInter118"
] | Abarelix | Aripiprazole | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Moderate | 1 | [
[
[
618,
24,
673
]
],
[
[
618,
24,
827
],
[
827,
40,
673
]
],
[
[
618,
24,
1630
],
[
1630,
1,
673
]
],
[
[
618,
23,
112
],
[
112,
23... | [
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aripiprazole"
]
],
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trazodone"
],
[
... | Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Trazodone and Trazodone (Compound) resembles Aripiprazole (Compound)
Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Perphenazine and Perphenazine (Compound) resembles Aripiprazole (Compound... |
DB00637 | DB05294 | 1,557 | 1,069 | [
"DDInter128",
"DDInter1917"
] | Astemizole | Vandetanib | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Major | 2 | [
[
[
1557,
25,
1069
]
],
[
[
1557,
6,
8374
],
[
8374,
45,
1069
]
],
[
[
1557,
23,
1247
],
[
1247,
23,
1069
]
],
[
[
1557,
24,
659
],
[
659,... | [
[
[
"Astemizole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vandetanib"
]
],
[
[
"Astemizole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Vandeta... | Astemizole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vandetanib (Compound)
Astemizole may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Vandetanib
Astemizole... |
DB01118 | DB08865 | 33 | 1,593 | [
"DDInter76",
"DDInter448"
] | Amiodarone | Crizotinib | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Major | 2 | [
[
[
33,
25,
1593
]
],
[
[
33,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
33,
7,
7260
],
[
7260,
46,
1593
]
],
[
[
33,
54,
19133
],
[
19133,
... | [
[
[
"Amiodarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
]
],
[
[
"Amiodarone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Crizoti... | Amiodarone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Amiodarone (Compound) upregulates MVD (Gene) and MVD (Gene) is upregulated by Crizotinib (Compound)
Amiodarone (Compound) is included by P-Glycoprotein Inhibitors (Pharmacologic Class) and P-Glycoprotein Inhibitors (Pharmacolo... |
DB00820 | DB11730 | 402 | 351 | [
"DDInter1736",
"DDInter1588"
] | Tadalafil | Ribociclib | Tadalafil is a selective phosphodiesterase-5 inhibitor that is used in the treatment of erectile dysfunction (ED), pulmonary arterial hypertension (PAH), and benign prostatic hypertrophy.[L39100, L39105] It was first approved in 2003 by the FDA for use in ED and later in 2009 for PAH. In contrast to other PDE5 inhibito... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
402,
24,
351
]
],
[
[
402,
24,
283
],
[
283,
62,
351
]
],
[
[
402,
24,
951
],
[
951,
24,
351
]
],
[
[
402,
63,
1324
],
[
1324,
2... | [
[
[
"Tadalafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Tadalafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
],
[
... | Tadalafil may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Tadalafil may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib and Palbocicl... |
DB00798 | DB00994 | 1,132 | 361 | [
"DDInter815",
"DDInter1277"
] | Gentamicin | Neomycin | Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negat... | Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as [framycetin], is the most active component of the complex and neomycin C is the isomer o... | Moderate | 1 | [
[
[
1132,
24,
361
]
],
[
[
1132,
40,
138
],
[
138,
1,
361
]
],
[
[
1132,
40,
11405
],
[
11405,
40,
361
]
],
[
[
1132,
54,
19175
],
[
19175... | [
[
[
"Gentamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Neomycin"
]
],
[
[
"Gentamicin",
"{u} (Compound) resembles {v} (Compound)",
"Tobramycin"
],
[
"Tobramycin",
"{u} (Compound) resembles ... | Gentamicin (Compound) resembles Tobramycin (Compound) and Tobramycin (Compound) resembles Neomycin (Compound)
Gentamicin (Compound) resembles Arbekacin (Compound) and Arbekacin (Compound) resembles Neomycin (Compound)
Gentamicin (Compound) is included by Aminoglycosides (Pharmacologic Class) and Aminoglycosides (Pharma... |
DB00470 | DB01173 | 530 | 358 | [
"DDInter601",
"DDInter1349"
] | Dronabinol | Orphenadrine | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm. | Moderate | 1 | [
[
[
530,
24,
358
]
],
[
[
530,
24,
272
],
[
272,
24,
358
]
],
[
[
530,
24,
820
],
[
820,
63,
358
]
],
[
[
530,
24,
758
],
[
758,
40,... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orphenadrine"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
],
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Alimema... |
DB00621 | DB00912 | 1,026 | 473 | [
"DDInter1357",
"DDInter1581"
] | Oxandrolone | Repaglinide | A synthetic hormone with anabolic and androgenic properties. | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Moderate | 1 | [
[
[
1026,
24,
473
]
],
[
[
1026,
21,
28845
],
[
28845,
60,
473
]
],
[
[
1026,
63,
1512
],
[
1512,
24,
473
]
],
[
[
1026,
40,
155
],
[
155,... | [
[
[
"Oxandrolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
]
],
[
[
"Oxandrolone",
"{u} (Compound) causes {v} (Side Effect)",
"Oedema"
],
[
"Oedema",
"{u} (Side Effect) is caused ... | Oxandrolone (Compound) causes Oedema (Side Effect) and Oedema (Side Effect) is caused by Repaglinide (Compound)
Oxandrolone may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Repaglinid... |
DB00361 | DB11988 | 134 | 270 | [
"DDInter1939",
"DDInter1321"
] | Vinorelbine | Ocrelizumab | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
134,
24,
270
]
],
[
[
134,
63,
1461
],
[
1461,
23,
270
]
],
[
[
134,
24,
1060
],
[
1060,
63,
270
]
],
[
[
134,
24,
1491
],
[
1491,
... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ocrelizumab
Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Enfortumab vedotin and... |
DB01309 | DB12015 | 1,254 | 1,033 | [
"DDInter933",
"DDInter53"
] | Insulin glulisine | Alpelisib | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
1254,
24,
1033
]
],
[
[
1254,
24,
154
],
[
154,
24,
1033
]
],
[
[
1254,
63,
772
],
[
772,
24,
1033
]
],
[
[
1254,
24,
1385
],
[
1385,
... | [
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurasidone"
... | Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Lurasidone and Lurasidone may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Carvedil... |
DB00792 | DB00934 | 832 | 413 | [
"DDInter1878",
"DDInter1124"
] | Tripelennamine | Maprotiline | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Moderate | 1 | [
[
[
832,
24,
413
]
],
[
[
832,
63,
1302
],
[
1302,
40,
413
]
],
[
[
832,
1,
293
],
[
293,
40,
413
]
],
[
[
832,
40,
11233
],
[
11233,
... | [
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Maprotiline"
]
],
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Protriptyline"
... | Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Protriptyline and Protriptyline (Compound) resembles Maprotiline (Compound)
Tripelennamine (Compound) resembles Imipramine (Compound) and Imipramine (Compound) resembles Maprotiline (Compound)
Tripelennamine (Compound) resemb... |
DB00835 | DB08897 | 100 | 1,429 | [
"DDInter245",
"DDInter22"
] | Brompheniramine | Aclidinium | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Aclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease (COPD). It has a much higher propensity to bind to muscarinic receptors than nicotinic receptors. FDA approved on July 24, 2012. | Moderate | 1 | [
[
[
100,
24,
1429
]
],
[
[
100,
63,
352
],
[
352,
24,
1429
]
],
[
[
100,
24,
1511
],
[
1511,
24,
1429
]
],
[
[
100,
6,
4304
],
[
4304,
... | [
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aclidinium"
]
],
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trospium"
],
... | Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Trospium and Trospium may cause a moderate interaction that could exacerbate diseases when taken with Aclidinium
Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and... |
DB01221 | DB11130 | 1,190 | 407 | [
"DDInter1007",
"DDInter1344"
] | Ketamine | Opium | Ketamine is an NMDA receptor antagonist with a potent anesthetic effect. It was developed in 1963 as a replacement for phencyclidine (PCP) by Calvin Stevens at Parke Davis Laboratories. It started being used for veterinary purposes in Belgium and in 1964 was proven that compared to PCP, it produced minor hallucinogenic... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
1190,
24,
407
]
],
[
[
1190,
63,
662
],
[
662,
24,
407
]
],
[
[
1190,
24,
849
],
[
849,
24,
407
]
],
[
[
1190,
24,
1609
],
[
1609,
... | [
[
[
"Ketamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Ketamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
[
"C... | Ketamine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Ketamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramin... |
DB00557 | DB12332 | 252 | 1,619 | [
"DDInter895",
"DDInter1626"
] | Hydroxyzine | Rucaparib | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
252,
24,
1619
]
],
[
[
252,
24,
222
],
[
222,
23,
1619
]
],
[
[
252,
23,
112
],
[
112,
23,
1619
]
],
[
[
252,
24,
1662
],
[
1662,
... | [
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Hydroxyzine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metr... |
DB00262 | DB00827 | 552 | 646 | [
"DDInter302",
"DDInter383"
] | Carmustine | Cinoxacin | A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogen... | Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections. | Minor | 0 | [
[
[
552,
23,
646
]
],
[
[
552,
21,
28691
],
[
28691,
60,
646
]
],
[
[
552,
24,
77
],
[
77,
62,
646
]
],
[
[
552,
24,
322
],
[
322,
2... | [
[
[
"Carmustine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cinoxacin"
]
],
[
[
"Carmustine",
"{u} (Compound) causes {v} (Side Effect)",
"Somnolence"
],
[
"Somnolence",
"{u} (Side Effect) is cause... | Carmustine (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Cinoxacin (Compound)
Carmustine may cause a moderate interaction that could exacerbate diseases when taken with Idarubicin and Idarubicin may cause a minor interaction that can limit clinical effects when taken with Cinoxaci... |
DB00377 | DB12245 | 1,494 | 823 | [
"DDInter1382",
"DDInter1863"
] | Palonosetron | Triclabendazole | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
1494,
24,
823
]
],
[
[
1494,
23,
1247
],
[
1247,
23,
823
]
],
[
[
1494,
24,
1612
],
[
1612,
24,
823
]
],
[
[
1494,
63,
1010
],
[
1010,... | [
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Palonosetron",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
... | Palonosetron may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Fost... |
DB00284 | DB00816 | 1,647 | 1,674 | [
"DDInter11",
"DDInter1346"
] | Acarbose | Orciprenaline | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Moderate | 1 | [
[
[
1647,
24,
1674
]
],
[
[
1647,
24,
874
],
[
874,
24,
1674
]
],
[
[
1647,
21,
28845
],
[
28845,
60,
1674
]
],
[
[
1647,
24,
251
],
[
251... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orciprenaline"
]
],
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
],
[
... | Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Orciprenaline
Acarbose (Compound) causes Oedema (Side Effect) and Oedema (Side Effect) is caused by Orciprenaline (Compound... |
DB00468 | DB01169 | 1,424 | 57 | [
"DDInter1557",
"DDInter120"
] | Quinine | Arsenic trioxide | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Major | 2 | [
[
[
1424,
25,
57
]
],
[
[
1424,
6,
8374
],
[
8374,
45,
57
]
],
[
[
1424,
23,
1247
],
[
1247,
23,
57
]
],
[
[
1424,
24,
603
],
[
603,
... | [
[
[
"Quinine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
]
],
[
[
"Quinine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Arsenic... | Quinine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Arsenic trioxide (Compound)
Quinine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Arsenic trioxide
Quin... |
DB00502 | DB08912 | 1,300 | 1,040 | [
"DDInter853",
"DDInter462"
] | Haloperidol | Dabrafenib | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
1300,
24,
1040
]
],
[
[
1300,
6,
4973
],
[
4973,
45,
1040
]
],
[
[
1300,
18,
2183
],
[
2183,
57,
1040
]
],
[
[
1300,
21,
28779
],
[
28... | [
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Haloperidol",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",... | Haloperidol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dabrafenib (Compound)
Haloperidol (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Dabrafenib (Compound)
Haloperidol (Compound) causes Dry mouth (Side Effect) and Dry mouth (Side Effect) is caused by Dabrafenib (Compound)
H... |
DB05294 | DB09082 | 1,069 | 659 | [
"DDInter1917",
"DDInter1934"
] | Vandetanib | Vilanterol | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
1069,
24,
659
]
],
[
[
1069,
63,
1220
],
[
1220,
23,
659
]
],
[
[
1069,
64,
1570
],
[
1570,
24,
659
]
],
[
[
1069,
25,
927
],
[
927,
... | [
[
[
"Vandetanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Vandetanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
[... | Vandetanib may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Vandetanib may lead to a major life threatening interaction when taken with Azithromycin and Azithromycin ma... |
DB00686 | DB11703 | 383 | 405 | [
"DDInter1424",
"DDInter9"
] | Pentosan polysulfate | Acalabrutinib | Pentosan polysulfate is a sulfated pentosyl polysaccharide with heparin-like properties. | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Moderate | 1 | [
[
[
383,
24,
405
]
],
[
[
383,
24,
765
],
[
765,
24,
405
]
],
[
[
383,
63,
126
],
[
126,
25,
405
]
],
[
[
383,
24,
802
],
[
802,
25,... | [
[
[
"Pentosan polysulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Pentosan polysulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hemi... | Pentosan polysulfate may cause a moderate interaction that could exacerbate diseases when taken with Hemin and Hemin may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Pentosan polysulfate may cause a moderate interaction that could exacerbate diseases when taken with Warfarin... |
DB00635 | DB14444 | 1,573 | 151 | [
"DDInter1515",
"DDInter924"
] | Prednisone | Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immuno... | Moderate | 1 | [
[
[
1573,
24,
151
]
],
[
[
1573,
63,
66
],
[
66,
24,
151
]
],
[
[
1573,
24,
1619
],
[
1619,
24,
151
]
],
[
[
1573,
1,
175
],
[
175,
... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)"
]
],
[
[
"Prednisone",
"{u} may cause a moderate interaction that could e... | Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Prednisone may cause a moderate inter... |
DB00059 | DB00439 | 1,560 | 289 | [
"DDInter1404",
"DDInter341"
] | Pegaspargase | Cerivastatin | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | On August 8, 2001 the U.S. Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew Baycol from the U.S. market, due to reports of fatal rhabdomyolysis, a severe adverse reaction from this cholesterol-lowering (lipid-lowering) product. It has also been withdrawn from the Cana... | Moderate | 1 | [
[
[
1560,
24,
289
]
],
[
[
1560,
24,
384
],
[
384,
63,
289
]
],
[
[
1560,
24,
912
],
[
912,
24,
289
]
],
[
[
1560,
25,
908
],
[
908,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cerivastatin"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Cerivastatin
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Interferon beta... |
DB01149 | DB06626 | 851 | 263 | [
"DDInter1274",
"DDInter147"
] | Nefazodone | Axitinib | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | Major | 2 | [
[
[
851,
25,
263
]
],
[
[
851,
63,
1215
],
[
1215,
23,
263
]
],
[
[
851,
63,
322
],
[
322,
24,
263
]
],
[
[
851,
25,
392
],
[
392,
2... | [
[
[
"Nefazodone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Axitinib"
]
],
[
[
"Nefazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lansoprazole"
],
[
"Lansoprazo... | Nefazodone may cause a moderate interaction that could exacerbate diseases when taken with Lansoprazole and Lansoprazole may cause a minor interaction that can limit clinical effects when taken with Axitinib
Nefazodone may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirub... |
DB00295 | DB01162 | 475 | 195 | [
"DDInter1244",
"DDInter1767"
] | Morphine | Terazosin | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Terazosin is a quinazoline derivative alpha-1-selective adrenergic blocking agent indicated for benign prostatic hyperplasia and hypertension[FDA Label]. Terazosin blocks adrenaline's action on alpha-1 adrenergic receptors, causing relaxation of smooth muscle in blood vessels and the prostate. | Moderate | 1 | [
[
[
475,
24,
195
]
],
[
[
475,
24,
1205
],
[
1205,
40,
195
]
],
[
[
475,
6,
4973
],
[
4973,
45,
195
]
],
[
[
475,
21,
28743
],
[
28743,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Terazosin"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prazosin"
],
[
"Pr... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Prazosin and Prazosin (Compound) resembles Terazosin (Compound)
Morphine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Terazosin (Compound)
Morphine (Compound) causes Atrial fibrillation (Side Effect) and Atrial fibril... |
DB00069 | DB00641 | 367 | 467 | [
"DDInter946",
"DDInter1675"
] | Interferon alfacon-1 | Simvastatin | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Moderate | 1 | [
[
[
367,
24,
467
]
],
[
[
367,
24,
279
],
[
279,
62,
467
]
],
[
[
367,
24,
110
],
[
110,
63,
467
]
],
[
[
367,
25,
72
],
[
72,
63,
... | [
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Simvastatin"
]
],
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anisin... | Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Anisindione and Anisindione may cause a minor interaction that can limit clinical effects when taken with Simvastatin
Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB01612 | DB06016 | 1,637 | 1,508 | [
"DDInter92",
"DDInter300"
] | Amyl Nitrite | Cariprazine | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary. It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT<sub>1A</sub> receptors and as an antagonist at serotonin 5-HT<sub>2A</sub> receptors. Cariprazine has been investigated in... | Moderate | 1 | [
[
[
1637,
24,
1508
]
],
[
[
1637,
24,
1450
],
[
1450,
63,
1508
]
],
[
[
1637,
63,
1614
],
[
1614,
24,
1508
]
],
[
[
1637,
63,
475
],
[
475... | [
[
[
"Amyl Nitrite",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cariprazine"
]
],
[
[
"Amyl Nitrite",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
],
... | Amyl Nitrite may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Cariprazine
Amyl Nitrite may cause a moderate interaction that could exacerbate diseases when taken with Nabilone a... |
DB06186 | DB14730 | 1,439 | 1,412 | [
"DDInter969",
"DDInter264"
] | Ipilimumab | Calaspargase pegol | Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes.[A35065,A35080,L12126] Ipilimumab was developed by Bristol-Myers Squibb and Medarex. Ipilimumab was granted FDA approva... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
1439,
24,
1412
]
],
[
[
1439,
25,
792
],
[
792,
24,
1412
]
],
[
[
1439,
64,
553
],
[
553,
24,
1412
]
],
[
[
1439,
63,
322
],
[
322,
... | [
[
[
"Ipilimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Ipilimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rivaroxaban"
],
[
"R... | Ipilimumab may lead to a major life threatening interaction when taken with Rivaroxaban and Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Ipilimumab may lead to a major life threatening interaction when taken with Fondaparinux and Fondaparinux may cause a... |
DB01268 | DB09564 | 1,151 | 1,296 | [
"DDInter1731",
"DDInter930"
] | Sunitinib | Insulin degludec | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
1151,
24,
1296
]
],
[
[
1151,
64,
17
],
[
17,
24,
1296
]
],
[
[
1151,
63,
1411
],
[
1411,
24,
1296
]
],
[
[
1151,
24,
659
],
[
659,
... | [
[
[
"Sunitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Sunitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sotalol"
],
[
"Sotalol",... | Sunitinib may lead to a major life threatening interaction when taken with Sotalol and Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause ... |
DB09036 | DB14783 | 812 | 287 | [
"DDInter1668",
"DDInter574"
] | Siltuximab | Diroximel fumarate | Siltuximab is a chimeric (human-mouse) monoclonal immunoglobulin G1-kappa antibody produced in a Chinese hamster ovary (CHO) cell line by recombinant DNA technology. Siltuximab prevents the binding of IL-6 to soluble and membrane-bound IL-6 receptors by forming high affinity complexes with human interleukin-6 (IL-6). I... | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
812,
24,
287
]
],
[
[
812,
63,
599
],
[
599,
24,
287
]
],
[
[
812,
24,
270
],
[
270,
24,
287
]
],
[
[
812,
64,
1510
],
[
1510,
2... | [
[
[
"Siltuximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Siltuximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alemtuzumab"
],... | Siltuximab may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab and Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Siltuximab may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab... |
DB00748 | DB01619 | 662 | 830 | [
"DDInter297",
"DDInter1441"
] | Carbinoxamine | Phenindamine | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Moderate | 1 | [
[
[
662,
24,
830
]
],
[
[
662,
63,
1251
],
[
1251,
1,
830
]
],
[
[
662,
24,
537
],
[
537,
40,
830
]
],
[
[
662,
63,
1219
],
[
1219,
... | [
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
]
],
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mirtazapine"
],... | Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Mirtazapine and Mirtazapine (Compound) resembles Phenindamine (Compound)
Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) resembles Phenindamine (... |
DB00031 | DB06605 | 20 | 1,409 | [
"DDInter1764",
"DDInter108"
] | Tenecteplase | Apixaban | Tenecteplase is a tissue plasminogen activator (tPA) developed from modifications of natural human tPA complementary DNA (cDNA). It is a 527 amino acid with a substitution of threonine 103 with asparagine and substitution of asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at ... | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Major | 2 | [
[
[
20,
25,
1409
]
],
[
[
20,
23,
539
],
[
539,
62,
1409
]
],
[
[
20,
24,
109
],
[
109,
24,
1409
]
],
[
[
20,
24,
41
],
[
41,
63,
... | [
[
[
"Tenecteplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apixaban"
]
],
[
[
"Tenecteplase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsicum",
... | Tenecteplase may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Apixaban
Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxetine m... |
DB00305 | DB00531 | 377 | 450 | [
"DDInter1232",
"DDInter456"
] | Mitomycin | Cyclophosphamide | Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of _Streptomyces caespitosus_.[L12867,A193419] It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations, RNA and protein synthesis) by cross-linking the complementary strands of th... | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | Moderate | 1 | [
[
[
377,
24,
450
]
],
[
[
377,
24,
1001
],
[
1001,
40,
450
]
],
[
[
377,
6,
4973
],
[
4973,
45,
450
]
],
[
[
377,
7,
5818
],
[
5818,
... | [
[
[
"Mitomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclophosphamide"
]
],
[
[
"Mitomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mechlorethamine"
],... | Mitomycin may cause a moderate interaction that could exacerbate diseases when taken with Mechlorethamine and Mechlorethamine (Compound) resembles Cyclophosphamide (Compound)
Mitomycin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Cyclophosphamide (Compound)
Mitomycin (Compound) upregulates ATP6V0B (Gene) ... |
DB01004 | DB01254 | 563 | 1,213 | [
"DDInter806",
"DDInter484"
] | Ganciclovir | Dasatinib | An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections. | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
563,
24,
1213
]
],
[
[
563,
7,
14690
],
[
14690,
46,
1213
]
],
[
[
563,
18,
10375
],
[
10375,
57,
1213
]
],
[
[
563,
21,
28882
],
[
28... | [
[
[
"Ganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Ganciclovir",
"{u} (Compound) upregulates {v} (Gene)",
"ABHD6"
],
[
"ABHD6",
"{u} (Gene) is upregulated by {v} (... | Ganciclovir (Compound) upregulates ABHD6 (Gene) and ABHD6 (Gene) is upregulated by Dasatinib (Compound)
Ganciclovir (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Dasatinib (Compound)
Ganciclovir (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Sid... |
DB00087 | DB00446 | 599 | 597 | [
"DDInter41",
"DDInter351"
] | Alemtuzumab | Chloramphenicol | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Moderate | 1 | [
[
[
599,
24,
597
]
],
[
[
599,
24,
1101
],
[
1101,
23,
597
]
],
[
[
599,
24,
450
],
[
450,
62,
597
]
],
[
[
599,
24,
1626
],
[
1626,
... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphenicol"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Chloramphenicol
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Cyclophosphamide... |
DB06700 | DB09472 | 643 | 1,383 | [
"DDInter511",
"DDInter1693"
] | Desvenlafaxine | Sodium sulfate | Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of ad... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
643,
24,
1383
]
],
[
[
643,
63,
1311
],
[
1311,
24,
1383
]
],
[
[
643,
64,
1466
],
[
1466,
24,
1383
]
],
[
[
643,
24,
1618
],
[
1618,
... | [
[
[
"Desvenlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Desvenlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"... | Desvenlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Desvenlafaxine may lead to a major life threatening interaction when taken with Phenylpropanolam... |
DB00390 | DB01001 | 1,252 | 688 | [
"DDInter554",
"DDInter1632"
] | Digoxin | Salbutamol | Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also known as the _Digi... | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Moderate | 1 | [
[
[
1252,
24,
688
]
],
[
[
1252,
24,
874
],
[
874,
24,
688
]
],
[
[
1252,
63,
1636
],
[
1636,
24,
688
]
],
[
[
1252,
24,
1148
],
[
1148,
... | [
[
[
"Digoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
]
],
[
[
"Digoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
],
[
"... | Digoxin may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Digoxin may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine and Phenyle... |
DB00658 | DB00827 | 965 | 646 | [
"DDInter1663",
"DDInter383"
] | Sevelamer | Cinoxacin | Sevelamer is a phosphate binding drug used to prevent hyperphosphataemia in patients with chronic renal failure. It is marketed by Genzyme under the trade name Renagel. | Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections. | Moderate | 1 | [
[
[
965,
24,
646
]
],
[
[
965,
21,
28722
],
[
28722,
60,
646
]
],
[
[
965,
24,
1096
],
[
1096,
63,
646
]
],
[
[
965,
21,
28722
],
[
28722,... | [
[
[
"Sevelamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cinoxacin"
]
],
[
[
"Sevelamer",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused by {v}... | Sevelamer (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Cinoxacin (Compound)
Sevelamer may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid and Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Ci... |
DB01253 | DB08912 | 628 | 1,040 | [
"DDInter664",
"DDInter462"
] | Ergometrine | Dabrafenib | An ergot alkaloid with uterine and vascular smooth muscle contractile properties. | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
628,
24,
1040
]
],
[
[
628,
6,
4973
],
[
4973,
45,
1040
]
],
[
[
628,
7,
3727
],
[
3727,
46,
1040
]
],
[
[
628,
18,
2999
],
[
2999,
... | [
[
[
"Ergometrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Ergometrine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",... | Ergometrine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dabrafenib (Compound)
Ergometrine (Compound) upregulates MAL (Gene) and MAL (Gene) is upregulated by Dabrafenib (Compound)
Ergometrine (Compound) downregulates PTPRK (Gene) and PTPRK (Gene) is upregulated by Dabrafenib (Compound)
Ergometrine (Compou... |
DB04844 | DB09291 | 843 | 741 | [
"DDInter1778",
"DDInter1615"
] | Tetrabenazine | Rolapitant | A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008. | Rolapitant is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and vomiting (CINV) in adults. Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated by Neurokinin-1 and its l... | Moderate | 1 | [
[
[
843,
24,
741
]
],
[
[
843,
1,
479
],
[
479,
23,
741
]
],
[
[
843,
63,
506
],
[
506,
24,
741
]
],
[
[
843,
64,
401
],
[
401,
24,
... | [
[
[
"Tetrabenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
]
],
[
[
"Tetrabenazine",
"{u} (Compound) resembles {v} (Compound)",
"Donepezil"
],
[
"Donepezil",
"{u} may cause a min... | Tetrabenazine (Compound) resembles Donepezil (Compound) and Donepezil may cause a minor interaction that can limit clinical effects when taken with Rolapitant
Tetrabenazine may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan and Dextromethorphan may cause a moderate interact... |
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