drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01222 | DB11652 | 617 | 1,155 | [
"DDInter246",
"DDInter1891"
] | Budesonide | Tucatinib | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Tucatinib is a kinase inhibitor drug used with [trastuzumab] and [capecitabine] in the treatment of unresectable or metastatic HER-2 positive breast cancer. It was developed by Seattle Genetics and approved by the FDA on April 17, 2020. Tucatinib is a promising new treatment for patients with metastatic breast cancer w... | Major | 2 | [
[
[
617,
25,
1155
]
],
[
[
617,
23,
659
],
[
659,
24,
1155
]
],
[
[
617,
64,
609
],
[
609,
24,
1155
]
],
[
[
617,
63,
522
],
[
522,
... | [
[
[
"Budesonide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tucatinib"
]
],
[
[
"Budesonide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vilanterol"
],
[
"Vilanterol",
... | Budesonide may cause a minor interaction that can limit clinical effects when taken with Vilanterol and Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Tucatinib
Budesonide may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin may c... |
DB08901 | DB11989 | 1,468 | 1,434 | [
"DDInter1492",
"DDInter183"
] | Ponatinib | Benznidazole | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Benznidazole was granted accelerated approval for the treatment of Chagas disease in children 2-12 years of age by the FDA on August 29, 2017. It is the first treatment made available in the United States for Chagas disease. | Moderate | 1 | [
[
[
1468,
24,
1434
]
],
[
[
1468,
63,
788
],
[
788,
24,
1434
]
],
[
[
1468,
25,
375
],
[
375,
24,
1434
]
],
[
[
1468,
24,
148
],
[
148,
... | [
[
[
"Ponatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benznidazole"
]
],
[
[
"Ponatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
],
[
... | Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Benznidazole
Ponatinib may lead to a major life threatening interaction when taken with Certolizumab pegol and Certolizu... |
DB00682 | DB01332 | 126 | 731 | [
"DDInter1951",
"DDInter332"
] | Warfarin | Ceftizoxime | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to b... | Moderate | 1 | [
[
[
126,
24,
731
]
],
[
[
126,
24,
1453
],
[
1453,
1,
731
]
],
[
[
126,
24,
1403
],
[
1403,
40,
731
]
],
[
[
126,
63,
1145
],
[
1145,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ceftizoxime"
]
],
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ceftriaxone"
],
[
... | Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Ceftriaxone and Ceftriaxone (Compound) resembles Ceftizoxime (Compound)
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Cefepime and Cefepime (Compound) resembles Ceftizoxime (Compound)
Warf... |
DB00446 | DB01067 | 597 | 959 | [
"DDInter351",
"DDInter826"
] | Chloramphenicol | Glipizide | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
597,
24,
959
]
],
[
[
597,
63,
245
],
[
245,
40,
959
]
],
[
[
597,
24,
1411
],
[
1411,
1,
959
]
],
[
[
597,
6,
8374
],
[
8374,
4... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
]... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizide... |
DB00366 | DB00382 | 1,594 | 62 | [
"DDInter600",
"DDInter1734"
] | Doxylamine | Tacrine | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market. | Moderate | 1 | [
[
[
1594,
24,
62
]
],
[
[
1594,
24,
1507
],
[
1507,
63,
62
]
],
[
[
1594,
40,
11
],
[
11,
63,
62
]
],
[
[
1594,
74,
701
],
[
701,
24... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tacrine"
]
],
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dicyclomine"
],
[
... | Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Dicyclomine and Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Tacrine
Doxylamine (Compound) resembles Toremifene (Compound) and Toremifene may cause a moderate interaction that could ... |
DB00204 | DB06176 | 228 | 1,342 | [
"DDInter580",
"DDInter1616"
] | Dofetilide | Romidepsin | Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter. | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Major | 2 | [
[
[
228,
25,
1342
]
],
[
[
228,
23,
112
],
[
112,
23,
1342
]
],
[
[
228,
25,
485
],
[
485,
24,
1342
]
],
[
[
228,
25,
1616
],
[
1616,
... | [
[
[
"Dofetilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Romidepsin"
]
],
[
[
"Dofetilide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronida... | Dofetilide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Romidepsin
Dofetilide may lead to a major life threatening interaction when taken with Pentamidine and Pentamidine may ca... |
DB00635 | DB01278 | 1,573 | 1,021 | [
"DDInter1515",
"DDInter1506"
] | Prednisone | Pramlintide | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Moderate | 1 | [
[
[
1573,
24,
1021
]
],
[
[
1573,
40,
1103
],
[
1103,
23,
1021
]
],
[
[
1573,
63,
1560
],
[
1560,
24,
1021
]
],
[
[
1573,
24,
1680
],
[
16... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pramlintide"
]
],
[
[
"Prednisone",
"{u} (Compound) resembles {v} (Compound)",
"Amcinonide"
],
[
"Amcinonide",
"{u} may cause a minor ... | Prednisone (Compound) resembles Amcinonide (Compound) and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Pramlintide
Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase and Pegaspargase may cause a moderate interaction that co... |
DB00446 | DB00480 | 597 | 1,668 | [
"DDInter351",
"DDInter1035"
] | Chloramphenicol | Lenalidomide | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Lenalidomide (previously referred to as CC-5013) is an immunomodulatory drug with potent antineoplastic, anti-angiogenic, and anti-inflammatory properties. It is a 4-amino-glutamyl analogue of [thalidomide] and like thalidomide, lenalidomide exists as a racemic mixture of the active S(-) and R(+) forms. However, lenali... | Moderate | 1 | [
[
[
597,
24,
1668
]
],
[
[
597,
24,
770
],
[
770,
40,
1668
]
],
[
[
597,
21,
28646
],
[
28646,
60,
1668
]
],
[
[
597,
24,
126
],
[
126,
... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lenalidomide"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and Thalidomide (Compound) resembles Lenalidomide (Compound)
Chloramphenicol (Compound) causes Unspecified disorder of skin and subcutaneous tissue (Side Effect) and Unspecified disorder of skin and subcutaneous ... |
DB01087 | DB09104 | 1,520 | 286 | [
"DDInter1520",
"DDInter1118"
] | Primaquine | Magnesium hydroxide | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
1520,
24,
286
]
],
[
[
1520,
24,
820
],
[
820,
23,
286
]
],
[
[
1520,
63,
401
],
[
401,
23,
286
]
],
[
[
1520,
24,
859
],
[
859,
... | [
[
[
"Primaquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Primaquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]... | Primaquine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Primaquine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine... |
DB00526 | DB09061 | 1,555 | 1,627 | [
"DDInter1355",
"DDInter284"
] | Oxaliplatin | Cannabidiol | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
1555,
24,
1627
]
],
[
[
1555,
24,
609
],
[
609,
23,
1627
]
],
[
[
1555,
63,
600
],
[
600,
23,
1627
]
],
[
[
1555,
25,
351
],
[
351,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
],
... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Cannabidiol
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole ... |
DB00631 | DB01045 | 372 | 463 | [
"DDInter405",
"DDInter1590"
] | Clofarabine | Rifampicin | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Moderate | 1 | [
[
[
372,
24,
463
]
],
[
[
372,
63,
1101
],
[
1101,
23,
463
]
],
[
[
372,
24,
1228
],
[
1228,
62,
463
]
],
[
[
372,
24,
1387
],
[
1387,
... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifampicin"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Rifampicin
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Lenvatinib and Lenvat... |
DB00092 | DB08901 | 58 | 1,468 | [
"DDInter40",
"DDInter1492"
] | Alefacept | Ponatinib | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
58,
24,
1468
]
],
[
[
58,
24,
478
],
[
478,
24,
1468
]
],
[
[
58,
24,
987
],
[
987,
63,
1468
]
],
[
[
58,
63,
599
],
[
599,
24,
... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-Hg... |
DB00563 | DB00697 | 663 | 876 | [
"DDInter1174",
"DDInter1821"
] | Methotrexate | Tizanidine | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury . It may also be caused by musculoskeletal injury . Regardless of the cause, muscle spasticity can be an extremely painful and debi... | Moderate | 1 | [
[
[
663,
24,
876
]
],
[
[
663,
5,
11594
],
[
11594,
49,
876
]
],
[
[
663,
18,
10780
],
[
10780,
57,
876
]
],
[
[
663,
21,
29054
],
[
29054... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tizanidine"
]
],
[
[
"Methotrexate",
"{u} (Compound) treats {v} (Disease)",
"multiple sclerosis"
],
[
"multiple sclerosis",
"{u} (Di... | Methotrexate (Compound) treats multiple sclerosis (Disease) and multiple sclerosis (Disease) is palliated by Tizanidine (Compound)
Methotrexate (Compound) downregulates CCNB2 (Gene) and CCNB2 (Gene) is downregulated by Tizanidine (Compound)
Methotrexate (Compound) causes Speech disorder (Side Effect) and Speech disorde... |
DB01033 | DB06674 | 328 | 908 | [
"DDInter1156",
"DDInter837"
] | Mercaptopurine | Golimumab | An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Major | 2 | [
[
[
328,
25,
908
]
],
[
[
328,
63,
1461
],
[
1461,
23,
908
]
],
[
[
328,
24,
200
],
[
200,
63,
908
]
],
[
[
328,
24,
1136
],
[
1136,
... | [
[
[
"Mercaptopurine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Golimumab"
]
],
[
[
"Mercaptopurine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vita... | Mercaptopurine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Golimumab
Mercaptopurine may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans a... |
DB01081 | DB08883 | 1,688 | 1,597 | [
"DDInter571",
"DDInter1428"
] | Diphenoxylate | Perampanel | A meperidine congener used as an antidiarrheal, usually in combination with atropine. At high doses, it acts like morphine. Its unesterified metabolite difenoxin has similar properties and is used similarly. It has little or no analgesic activity. This medication is classified as a Schedule V under the Controlled Subst... | Perampanel is a noncompetitive AMPA glutamate receptor antagonist. It is marketed under the name Fycompa™ and is indicated as an adjunct in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures. The FDA label includes an important black-boxed warning ... | Moderate | 1 | [
[
[
1688,
24,
1597
]
],
[
[
1688,
24,
649
],
[
649,
24,
1597
]
],
[
[
1688,
63,
128
],
[
128,
24,
1597
]
],
[
[
1688,
40,
1118
],
[
1118,
... | [
[
[
"Diphenoxylate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perampanel"
]
],
[
[
"Diphenoxylate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],
... | Diphenoxylate may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Perampanel
Diphenoxylate may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniram... |
DB00214 | DB06655 | 1,028 | 5 | [
"DDInter1836",
"DDInter1077"
] | Torasemide | Liraglutide | Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993. | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Moderate | 1 | [
[
[
1028,
24,
5
]
],
[
[
1028,
24,
870
],
[
870,
24,
5
]
],
[
[
1028,
63,
176
],
[
176,
24,
5
]
],
[
[
1028,
24,
1019
],
[
1019,
63,... | [
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liraglutide"
]
],
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
],
... | Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Liraglutide
Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Insulin gl... |
DB00773 | DB00987 | 896 | 1,224 | [
"DDInter702",
"DDInter460"
] | Etoposide | Cytarabine | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant p... | Moderate | 1 | [
[
[
896,
24,
1224
]
],
[
[
896,
5,
11555
],
[
11555,
44,
1224
]
],
[
[
896,
6,
14544
],
[
14544,
45,
1224
]
],
[
[
896,
7,
7806
],
[
7806,... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cytarabine"
]
],
[
[
"Etoposide",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease)... | Etoposide (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Cytarabine (Compound)
Etoposide (Compound) binds ABCC10 (Gene) and ABCC10 (Gene) is bound by Cytarabine (Compound)
Etoposide (Compound) upregulates INPP1 (Gene) and INPP1 (Gene) is upregulated by Cytarabine (Compound... |
DB11003 | DB12332 | 748 | 1,619 | [
"DDInter100",
"DDInter1626"
] | Anthrax vaccine | Rucaparib | Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsula... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
748,
24,
1619
]
],
[
[
748,
63,
259
],
[
259,
24,
1619
]
],
[
[
748,
24,
1019
],
[
1019,
24,
1619
]
],
[
[
748,
24,
1259
],
[
1259,
... | [
[
[
"Anthrax vaccine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Anthrax vaccine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
],... | Anthrax vaccine may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib
Anthrax vaccine may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort ... |
DB00552 | DB09498 | 1,238 | 810 | [
"DDInter1425",
"DDInter1715"
] | Pentostatin | Strontium chloride Sr-89 | A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Moderate | 1 | [
[
[
1238,
24,
810
]
],
[
[
1238,
63,
1555
],
[
1555,
24,
810
]
],
[
[
1238,
24,
1224
],
[
1224,
24,
810
]
],
[
[
1238,
74,
141
],
[
141,
... | [
[
[
"Pentostatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Strontium chloride Sr-89"
]
],
[
[
"Pentostatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin... | Pentostatin may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89
Pentostatin may cause a moderate interaction that could exacerbate diseases when taken with Cyt... |
DB00008 | DB01095 | 491 | 671 | [
"DDInter1407",
"DDInter769"
] | Peginterferon alfa-2a | Fluvastatin | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin belongs to a class of medications called statins and is used to r... | Moderate | 1 | [
[
[
491,
24,
671
]
],
[
[
491,
24,
788
],
[
788,
40,
671
]
],
[
[
491,
24,
14
],
[
14,
63,
671
]
],
[
[
491,
24,
126
],
[
126,
23,
... | [
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
]
],
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pita... | Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin (Compound) resembles Fluvastatin (Compound)
Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin and Rosuvastatin may cause a ... |
DB00358 | DB15093 | 1,010 | 1,654 | [
"DDInter1140",
"DDInter1698"
] | Mefloquine | Somapacitan | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
1010,
24,
1654
]
],
[
[
1010,
63,
608
],
[
608,
23,
1654
]
],
[
[
1010,
25,
351
],
[
351,
24,
1654
]
],
[
[
1010,
24,
1250
],
[
1250,
... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
... | Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Somapacitan
Mefloquine may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause a m... |
DB00682 | DB09420 | 126 | 1,074 | [
"DDInter1951",
"DDInter953"
] | Warfarin | Iodide I-123 | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Moderate | 1 | [
[
[
126,
24,
1074
]
],
[
[
126,
64,
161
],
[
161,
24,
1074
]
],
[
[
126,
25,
500
],
[
500,
24,
1074
]
],
[
[
126,
24,
1004
],
[
1004,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
]
],
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sulfadiazine"
],
[
"Sulfadiazi... | Warfarin may lead to a major life threatening interaction when taken with Sulfadiazine and Sulfadiazine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123
Warfarin may lead to a major life threatening interaction when taken with Enoxaparin and Enoxaparin may cause a moderate in... |
DB00364 | DB01344 | 417 | 1,231 | [
"DDInter1717",
"DDInter1830"
] | Sucralfate | Tolevamer | Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia. It is considered a _cytoprotective agent_, protect... | Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines. It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among others, H... | Moderate | 1 | [
[
[
417,
24,
1231
]
],
[
[
417,
62,
1152
],
[
1152,
24,
1231
]
],
[
[
417,
23,
542
],
[
542,
24,
1231
]
],
[
[
417,
24,
1252
],
[
1252,
... | [
[
[
"Sucralfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolevamer"
]
],
[
[
"Sucralfate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Liothyronine"
],
[
... | Sucralfate may cause a minor interaction that can limit clinical effects when taken with Liothyronine and Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Tolevamer
Sucralfate may cause a minor interaction that can limit clinical effects when taken with Levothyroxine and Levo... |
DB00446 | DB09276 | 597 | 381 | [
"DDInter351",
"DDInter1682"
] | Chloramphenicol | Sodium aurothiomalate | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in active progressive rheumatoid arthritis and of little or no valu... | Moderate | 1 | [
[
[
597,
24,
381
]
],
[
[
597,
24,
1683
],
[
1683,
24,
381
]
],
[
[
597,
63,
491
],
[
491,
24,
381
]
],
[
[
597,
24,
1480
],
[
1480,
... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium aurothiomalate"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Usteki... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Sodium aurothiomalate
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00180 | DB01211 | 1,351 | 609 | [
"DDInter750",
"DDInter393"
] | Flunisolide (nasal) | Clarithromycin | Flunisolide can cause developmental toxicity and female reproductive toxicity according to state or federal government labeling requirements. | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
1351,
24,
609
]
],
[
[
1351,
6,
8374
],
[
8374,
45,
609
]
],
[
[
1351,
18,
8733
],
[
8733,
57,
609
]
],
[
[
1351,
21,
28662
],
[
28662... | [
[
[
"Flunisolide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Flunisolide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compo... | Flunisolide may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Flunisolide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Clarithromycin (Compound)
Flunisolide (Compound) downregulates PHGDH (Gene) and PHGDH (Gene) is downregulated by Clarithromycin (Compound)
F... |
DB00372 | DB00601 | 999 | 453 | [
"DDInter1793",
"DDInter1073"
] | Thiethylperazine | Linezolid | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Moderate | 1 | [
[
[
999,
24,
453
]
],
[
[
999,
24,
272
],
[
272,
63,
453
]
],
[
[
999,
24,
1233
],
[
1233,
24,
453
]
],
[
[
999,
63,
1214
],
[
1214,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linezolid"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Linezolid
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB06655 | DB11255 | 5 | 1,371 | [
"DDInter1077",
"DDInter374"
] | Liraglutide | Chromium picolinate | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Chromium picolinate has a chemical formula CrPic3 and reddish-pink color. It is a coordination complex consisting of chromium(III) and picolinic acid. Chromium picolinate is used as a nutritional supplement for optimal insulin function in patients with Type 2 diabetes or promotion of weight loss. Chromium ions are show... | Moderate | 1 | [
[
[
5,
24,
1371
]
],
[
[
5,
63,
245
],
[
245,
24,
1371
]
],
[
[
5,
24,
1296
],
[
1296,
24,
1371
]
],
[
[
5,
63,
245
],
[
245,
24,
... | [
[
[
"Liraglutide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chromium picolinate"
]
],
[
[
"Liraglutide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
... | Liraglutide may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Chromium picolinate
Liraglutide may cause a moderate interaction that could exacerbate diseases when taken with Insulin ... |
DB00358 | DB00420 | 1,010 | 508 | [
"DDInter1140",
"DDInter1532"
] | Mefloquine | Promazine | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | Moderate | 1 | [
[
[
1010,
24,
508
]
],
[
[
1010,
24,
1264
],
[
1264,
63,
508
]
],
[
[
1010,
24,
1630
],
[
1630,
1,
508
]
],
[
[
1010,
24,
1236
],
[
1236,
... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promazine"
]
],
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promazine
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Perphenazine and Perphenazin... |
DB06700 | DB11095 | 643 | 235 | [
"DDInter511",
"DDInter505"
] | Desvenlafaxine | Desirudin | Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of ad... | Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three dis... | Moderate | 1 | [
[
[
643,
24,
235
]
],
[
[
643,
40,
1100
],
[
1100,
24,
235
]
],
[
[
643,
24,
578
],
[
578,
24,
235
]
],
[
[
643,
63,
885
],
[
885,
2... | [
[
[
"Desvenlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desirudin"
]
],
[
[
"Desvenlafaxine",
"{u} (Compound) resembles {v} (Compound)",
"Venlafaxine"
],
[
"Venlafaxine",
"{u} may cause ... | Desvenlafaxine (Compound) resembles Venlafaxine (Compound) and Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Desirudin
Desvenlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a moderate interaction t... |
DB00861 | DB11703 | 914 | 405 | [
"DDInter551",
"DDInter9"
] | Diflunisal | Acalabrutinib | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Major | 2 | [
[
[
914,
25,
405
]
],
[
[
914,
23,
1384
],
[
1384,
24,
405
]
],
[
[
914,
63,
121
],
[
121,
24,
405
]
],
[
[
914,
24,
1017
],
[
1017,
... | [
[
[
"Diflunisal",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Diflunisal",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magaldrate"
],
[
"Magaldrat... | Diflunisal may cause a minor interaction that can limit clinical effects when taken with Magaldrate and Magaldrate may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine and Fen... |
DB01067 | DB06663 | 959 | 1,154 | [
"DDInter826",
"DDInter1398"
] | Glipizide | Pasireotide | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Moderate | 1 | [
[
[
959,
24,
1154
]
],
[
[
959,
63,
966
],
[
966,
40,
1154
]
],
[
[
959,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
959,
63,
1247
],
[
1247,
... | [
[
[
"Glipizide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pasireotide"
]
],
[
[
"Glipizide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Octreotide"
],
[
... | Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Octreotide and Octreotide (Compound) resembles Pasireotide (Compound)
Glipizide (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Glipizide may cause a moderate int... |
DB00529 | DB09330 | 789 | 985 | [
"DDInter779",
"DDInter1352"
] | Foscarnet | Osimertinib | An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV. | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Major | 2 | [
[
[
789,
25,
985
]
],
[
[
789,
23,
112
],
[
112,
23,
985
]
],
[
[
789,
24,
480
],
[
480,
24,
985
]
],
[
[
789,
24,
657
],
[
657,
63,... | [
[
[
"Foscarnet",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osimertinib"
]
],
[
[
"Foscarnet",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidaz... | Foscarnet may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Foscarnet may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formo... |
DB00673 | DB09049 | 723 | 1,135 | [
"DDInter112",
"DDInter1261"
] | Aprepitant | Naloxegol | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Naloxegol, for "PEGylated naloxol" is a peripherally-selective opioid antagonist developed by AstraZeneca. It was approved by the FDA in September 2014 and is indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non‑cancer pain. The advantage of naloxegol over the opioid antag... | Major | 2 | [
[
[
723,
25,
1135
]
],
[
[
723,
23,
807
],
[
807,
23,
1135
]
],
[
[
723,
24,
33
],
[
33,
23,
1135
]
],
[
[
723,
25,
1406
],
[
1406,
... | [
[
[
"Aprepitant",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
]
],
[
[
"Aprepitant",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ulipristal"
],
[
"Ulipristal",
... | Aprepitant may cause a minor interaction that can limit clinical effects when taken with Ulipristal and Ulipristal may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Amiodarone and Amiodarone ... |
DB00845 | DB08881 | 1,490 | 868 | [
"DDInter406",
"DDInter1925"
] | Clofazimine | Vemurafenib | Clofazimine is a highly lipophilic antimicrobial riminophenazine dye used in combination with other agents, such as [dapsone], for the treatment of leprosy. It was originally described in 1957 and was the prototypical riminophenazine dye - a bright-red dye that, in its clinical use, results in long-lasting discoloratio... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Major | 2 | [
[
[
1490,
25,
868
]
],
[
[
1490,
6,
8374
],
[
8374,
45,
868
]
],
[
[
1490,
7,
6717
],
[
6717,
46,
868
]
],
[
[
1490,
18,
16974
],
[
16974,... | [
[
[
"Clofazimine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
]
],
[
[
"Clofazimine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Vemu... | Clofazimine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vemurafenib (Compound)
Clofazimine (Compound) upregulates HERPUD1 (Gene) and HERPUD1 (Gene) is upregulated by Vemurafenib (Compound)
Clofazimine (Compound) downregulates TUBB6 (Gene) and TUBB6 (Gene) is downregulated by Vemurafenib (Compound)
Clof... |
DB01320 | DB06372 | 651 | 259 | [
"DDInter783",
"DDInter1594"
] | Fosphenytoin | Rilonacept | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
651,
24,
259
]
],
[
[
651,
24,
1619
],
[
1619,
63,
259
]
],
[
[
651,
25,
1456
],
[
1456,
63,
259
]
],
[
[
651,
63,
1573
],
[
1573,
... | [
[
[
"Fosphenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Fosphenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
],
[... | Fosphenytoin may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept
Fosphenytoin may lead to a major life threatening interaction when taken with Venetoclax and Venetoclax may caus... |
DB00468 | DB01036 | 1,424 | 211 | [
"DDInter1557",
"DDInter1832"
] | Quinine | Tolterodine | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence. Tolterodine acts on M2 and M3 subtypes of muscarinic receptors. | Minor | 0 | [
[
[
1424,
23,
211
]
],
[
[
1424,
24,
573
],
[
573,
40,
211
]
],
[
[
1424,
64,
494
],
[
494,
40,
211
]
],
[
[
1424,
63,
847
],
[
847,
... | [
[
[
"Quinine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Tolterodine"
]
],
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fesoterodine"
],
[
"... | Quinine may cause a moderate interaction that could exacerbate diseases when taken with Fesoterodine and Fesoterodine (Compound) resembles Tolterodine (Compound)
Quinine may lead to a major life threatening interaction when taken with Disopyramide and Disopyramide (Compound) resembles Tolterodine (Compound)
Quinine may... |
DB00759 | DB13257 | 1,620 | 260 | [
"DDInter1783",
"DDInter727"
] | Tetracycline | Ferrous sulfate anhydrous | Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some e... | Iron deficiency anemia is a large public health concern worldwide, especially in young children, infants, and women of childbearing age. This type of anemia occurs when iron intake, iron stores, and iron loss do not adequately support the formation of erythrocytes, also known as red blood cells. Ferrous sulfate is a sy... | Moderate | 1 | [
[
[
1620,
24,
260
]
],
[
[
1620,
24,
1114
],
[
1114,
23,
260
]
],
[
[
1620,
24,
489
],
[
489,
24,
260
]
],
[
[
1620,
1,
1545
],
[
1545,
... | [
[
[
"Tetracycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous sulfate anhydrous"
]
],
[
[
"Tetracycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc sul... | Tetracycline may cause a moderate interaction that could exacerbate diseases when taken with Zinc sulfate and Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Ferrous sulfate anhydrous
Tetracycline may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00500 | DB00563 | 24 | 663 | [
"DDInter1831",
"DDInter1174"
] | Tolmetin | Methotrexate | A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin. | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Major | 2 | [
[
[
24,
25,
663
]
],
[
[
24,
10,
11591
],
[
11591,
44,
663
]
],
[
[
24,
6,
10612
],
[
10612,
45,
663
]
],
[
[
24,
6,
7720
],
[
7720,
... | [
[
[
"Tolmetin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methotrexate"
]
],
[
[
"Tolmetin",
"{u} (Compound) palliates {v} (Disease)",
"ankylosing spondylitis"
],
[
"ankylosing spondylitis",
"{u} (Disease) is ... | Tolmetin (Compound) palliates ankylosing spondylitis (Disease) and ankylosing spondylitis (Disease) is treated by Methotrexate (Compound)
Tolmetin (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Methotrexate (Compound)
Tolmetin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Methotrexate... |
DB00283 | DB00356 | 701 | 1,315 | [
"DDInter395",
"DDInter366"
] | Clemastine | Chlorzoxazone | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202) | Moderate | 1 | [
[
[
701,
24,
1315
]
],
[
[
701,
6,
8374
],
[
8374,
45,
1315
]
],
[
[
701,
21,
28757
],
[
28757,
60,
1315
]
],
[
[
701,
35,
1242
],
[
1242,... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorzoxazone"
]
],
[
[
"Clemastine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Clemastine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Chlorzoxazone (Compound)
Clemastine (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Chlorzoxazone (Compound)
Clemastine (Compound) resembles Cetirizine (Compound) and Clemastine may cause a moderate interaction th... |
DB00934 | DB01128 | 413 | 918 | [
"DDInter1124",
"DDInter204"
] | Maprotiline | Bicalutamide | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Moderate | 1 | [
[
[
413,
24,
918
]
],
[
[
413,
24,
129
],
[
129,
40,
918
]
],
[
[
413,
6,
12523
],
[
12523,
45,
918
]
],
[
[
413,
18,
16974
],
[
16974,
... | [
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
]
],
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
... | Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide (Compound) resembles Bicalutamide (Compound)
Maprotiline (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Bicalutamide (Compound)
Maprotiline (Compound) downregulates TUBB6 (Gene) and TU... |
DB00719 | DB00761 | 1,219 | 1,621 | [
"DDInter149",
"DDInter1497"
] | Azatadine | Potassium chloride | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of potassium p... | Major | 2 | [
[
[
1219,
25,
1621
]
],
[
[
1219,
63,
1105
],
[
1105,
25,
1621
]
],
[
[
1219,
24,
667
],
[
667,
64,
1621
]
],
[
[
1219,
74,
1408
],
[
1408... | [
[
[
"Azatadine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Potassium chloride"
]
],
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trihexyphenidyl"
],
[
... | Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Trihexyphenidyl and Trihexyphenidyl may lead to a major life threatening interaction when taken with Potassium chloride
Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Solifenacin and Soli... |
DB00675 | DB06788 | 888 | 1,616 | [
"DDInter1744",
"DDInter864"
] | Tamoxifen | Histrelin | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Moderate | 1 | [
[
[
888,
24,
1616
]
],
[
[
888,
23,
112
],
[
112,
23,
1616
]
],
[
[
888,
24,
1664
],
[
1664,
24,
1616
]
],
[
[
888,
63,
1251
],
[
1251,
... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histrelin"
]
],
[
[
"Tamoxifen",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Tamoxifen may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risper... |
DB00352 | DB10315 | 482 | 1,137 | [
"DDInter1814",
"DDInter1127"
] | Tioguanine | Measles virus vaccine live attenuated | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
482,
25,
1137
]
],
[
[
482,
64,
581
],
[
581,
25,
1137
]
],
[
[
482,
24,
384
],
[
384,
25,
1137
]
],
[
[
482,
63,
1101
],
[
1101,
... | [
[
[
"Tioguanine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Tioguanine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Infliximab"
],
[
... | Tioguanine may lead to a major life threatening interaction when taken with Infliximab and Infliximab may lead to a major life threatening interaction when taken with Measles virus vaccine live attenuated
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisi... |
DB00960 | DB09156 | 887 | 777 | [
"DDInter1471",
"DDInter964"
] | Pindolol | Iopromide | Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the earl... | Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the flow path of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs. Although iopromide can... | Moderate | 1 | [
[
[
887,
24,
777
]
],
[
[
887,
40,
726
],
[
726,
24,
777
]
],
[
[
887,
24,
1013
],
[
1013,
63,
777
]
],
[
[
887,
63,
1648
],
[
1648,
... | [
[
[
"Pindolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopromide"
]
],
[
[
"Pindolol",
"{u} (Compound) resembles {v} (Compound)",
"Betaxolol"
],
[
"Betaxolol",
"{u} may cause a moderate inter... | Pindolol (Compound) resembles Betaxolol (Compound) and Betaxolol may cause a moderate interaction that could exacerbate diseases when taken with Iopromide
Pindolol may cause a moderate interaction that could exacerbate diseases when taken with Tyropanoic acid and Tyropanoic acid may cause a moderate interaction that co... |
DB08881 | DB09118 | 868 | 1,580 | [
"DDInter1925",
"DDInter1711"
] | Vemurafenib | Stiripentol | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Moderate | 1 | [
[
[
868,
24,
1580
]
],
[
[
868,
24,
466
],
[
466,
62,
1580
]
],
[
[
868,
63,
1409
],
[
1409,
24,
1580
]
],
[
[
868,
62,
168
],
[
168,
... | [
[
[
"Vemurafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stiripentol"
]
],
[
[
"Vemurafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
... | Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Stiripentol
Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Apixaban and Api... |
DB00851 | DB01155 | 611 | 872 | [
"DDInter463",
"DDInter813"
] | Dacarbazine | Gemifloxacin | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Minor | 0 | [
[
[
611,
23,
872
]
],
[
[
611,
23,
739
],
[
739,
1,
872
]
],
[
[
611,
62,
1299
],
[
1299,
1,
872
]
],
[
[
611,
23,
945
],
[
945,
40,... | [
[
[
"Dacarbazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Gemifloxacin"
]
],
[
[
"Dacarbazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lomefloxacin"
],
[
... | Dacarbazine may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gemifloxacin (Compound)
Dacarbazine may cause a minor interaction that can limit clinical effects when taken with Trovafloxacin and Trovafloxacin (Compound) resembles Gemifloxacin... |
DB00679 | DB09039 | 684 | 1,670 | [
"DDInter1796",
"DDInter629"
] | Thioridazine | Eliglustat | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Major | 2 | [
[
[
684,
25,
1670
]
],
[
[
684,
64,
121
],
[
121,
24,
1670
]
],
[
[
684,
24,
187
],
[
187,
24,
1670
]
],
[
[
684,
25,
594
],
[
594,
... | [
[
[
"Thioridazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eliglustat"
]
],
[
[
"Thioridazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fenfluramine"
],
[
"Fenfluramine",
... | Thioridazine may lead to a major life threatening interaction when taken with Fenfluramine and Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Eliglustat
Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with Pirfenidone and Pirfenidone ... |
DB00959 | DB01211 | 1,486 | 609 | [
"DDInter1191",
"DDInter393"
] | Methylprednisolone | Clarithromycin | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Major | 2 | [
[
[
1486,
25,
609
]
],
[
[
1486,
6,
4973
],
[
4973,
45,
609
]
],
[
[
1486,
7,
8155
],
[
8155,
46,
609
]
],
[
[
1486,
21,
28759
],
[
28759,... | [
[
[
"Methylprednisolone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
]
],
[
[
"Methylprednisolone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound... | Methylprednisolone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clarithromycin (Compound)
Methylprednisolone (Compound) upregulates ABCC5 (Gene) and ABCC5 (Gene) is upregulated by Clarithromycin (Compound)
Methylprednisolone (Compound) causes Connective tissue disorder (Side Effect) and Connective tissue ... |
DB00408 | DB01105 | 1,408 | 222 | [
"DDInter1099",
"DDInter1665"
] | Loxapine | Sibutramine | An antipsychotic agent used in schizophrenia. [PubChem] | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
1408,
24,
222
]
],
[
[
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[
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45,
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[
[
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21,
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],
[
29356,
60,
222
]
],
[
[
1408,
63,
128
],
[
128,
... | [
[
[
"Loxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Loxapine",
"{u} (Compound) binds {v} (Gene)",
"SLC6A4"
],
[
"SLC6A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Loxapine (Compound) binds SLC6A4 (Gene) and SLC6A4 (Gene) is bound by Sibutramine (Compound)
Loxapine (Compound) causes Salivary hypersecretion (Side Effect) and Salivary hypersecretion (Side Effect) is caused by Sibutramine (Compound)
Loxapine may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00374 | DB11827 | 1,061 | 433 | [
"DDInter1852",
"DDInter669"
] | Treprostinil | Ertugliflozin | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
1061,
24,
433
]
],
[
[
1061,
24,
1020
],
[
1020,
24,
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]
],
[
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1061,
63,
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],
[
217,
24,
433
]
],
[
[
1061,
35,
699
],
[
699,
... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clonidine"
],
... | Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Clonidine and Clonidine may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Olmesartan and O... |
DB05239 | DB13179 | 866 | 68 | [
"DDInter425",
"DDInter1882"
] | Cobimetinib | Troleandomycin | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | A macrolide antibiotic that is similar to erythromycin. | Major | 2 | [
[
[
866,
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[
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],
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],
[
[
866,
63,
267
],
[
267,
24... | [
[
[
"Cobimetinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Troleandomycin"
]
],
[
[
"Cobimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
"Bexa... | Cobimetinib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Troleandomycin
Cobimetinib may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and A... |
DB00275 | DB00372 | 217 | 999 | [
"DDInter1330",
"DDInter1793"
] | Olmesartan | Thiethylperazine | Olmesartan belongs to the angiotensin II receptor blocker (ARB) family of drugs, which also includes [telmisartan], [candesartan], [losartan], [valsartan], and [irbesartan]. ARBs selectively bind to angiotensin receptor 1 (AT1) and prevent the protein angiotensin II from binding and exerting its hypertensive effects, w... | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Moderate | 1 | [
[
[
217,
24,
999
]
],
[
[
217,
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],
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63,
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[
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217,
1,
911
],
[
911,
63,
999
]
],
[
[
217,
24,
475
],
[
475,
24... | [
[
[
"Olmesartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thiethylperazine"
]
],
[
[
"Olmesartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
],
... | Olmesartan may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine
Olmesartan (Compound) resembles Azilsartan medoxomil (Compound) and Azilsartan medoxomil may cause a moderate ... |
DB00059 | DB00912 | 1,560 | 473 | [
"DDInter1404",
"DDInter1581"
] | Pegaspargase | Repaglinide | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Moderate | 1 | [
[
[
1560,
24,
473
]
],
[
[
1560,
24,
1026
],
[
1026,
24,
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]
],
[
[
1560,
24,
540
],
[
540,
63,
473
]
],
[
[
1560,
25,
695
],
[
695,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxandrolone"
],
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Oxandrolone and Oxandrolone may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Dronedarone an... |
DB01001 | DB09268 | 688 | 1,662 | [
"DDInter1632",
"DDInter1464"
] | Salbutamol | Picosulfuric acid | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
688,
24,
1662
]
],
[
[
688,
63,
1252
],
[
1252,
23,
1662
]
],
[
[
688,
63,
1164
],
[
1164,
24,
1662
]
],
[
[
688,
24,
484
],
[
484,
... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digoxin"
],
... | Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin may cause a minor interaction that can limit clinical effects when taken with Picosulfuric acid
Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimi... |
DB00501 | DB05239 | 752 | 866 | [
"DDInter380",
"DDInter425"
] | Cimetidine | Cobimetinib | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Moderate | 1 | [
[
[
752,
24,
866
]
],
[
[
752,
24,
214
],
[
214,
63,
866
]
],
[
[
752,
25,
888
],
[
888,
24,
866
]
],
[
[
752,
24,
33
],
[
33,
24,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobimetinib"
]
],
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
],
[... | Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Cobimetinib
Cimetidine may lead to a major life threatening interaction when taken with Tamoxifen and Tamoxifen may cau... |
DB00468 | DB12161 | 1,424 | 730 | [
"DDInter1557",
"DDInter512"
] | Quinine | Deutetrabenazine | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Deutetrabenazine is a novel, highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor indicated for the management of chorea associated with Huntington’s disease. It is a hexahydro-dimethoxybenzoquinolizine derivative and a deuterated . The presence of deuterium in deutetrabenazine increases the half-lives ... | Moderate | 1 | [
[
[
1424,
24,
730
]
],
[
[
1424,
23,
112
],
[
112,
23,
730
]
],
[
[
1424,
63,
322
],
[
322,
24,
730
]
],
[
[
1424,
24,
1559
],
[
1559,
... | [
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deutetrabenazine"
]
],
[
[
"Quinine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Quinine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Deutetrabenazine
Quinine may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epir... |
DB00491 | DB00978 | 127 | 739 | [
"DDInter1217",
"DDInter1084"
] | Miglitol | Lomefloxacin | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Moderate | 1 | [
[
[
127,
24,
739
]
],
[
[
127,
24,
945
],
[
945,
40,
739
]
],
[
[
127,
25,
246
],
[
246,
40,
739
]
],
[
[
127,
63,
1176
],
[
1176,
1... | [
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomefloxacin"
]
],
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sparfloxacin"
],
[
... | Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Lomefloxacin (Compound)
Miglitol may lead to a major life threatening interaction when taken with Gatifloxacin and Gatifloxacin (Compound) resembles Lomefloxacin (Compound)
Miglito... |
DB06414 | DB09039 | 655 | 1,670 | [
"DDInter703",
"DDInter629"
] | Etravirine | Eliglustat | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Moderate | 1 | [
[
[
655,
24,
1670
]
],
[
[
655,
24,
1135
],
[
1135,
62,
1670
]
],
[
[
655,
24,
1409
],
[
1409,
24,
1670
]
],
[
[
655,
63,
187
],
[
187,
... | [
[
[
"Etravirine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eliglustat"
]
],
[
[
"Etravirine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
[
... | Etravirine may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Eliglustat
Etravirine may cause a moderate interaction that could exacerbate diseases when taken with Apixaban and Apixaban may... |
DB00723 | DB09080 | 1,240 | 144 | [
"DDInter1176",
"DDInter1331"
] | Methoxamine | Olodaterol | An alpha-adrenergic agonist that causes prolonged peripheral vasoconstriction. It has little if any direct effect on the central nervous system. | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
1240,
24,
144
]
],
[
[
1240,
63,
1048
],
[
1048,
24,
144
]
],
[
[
1240,
1,
1290
],
[
1290,
24,
144
]
],
[
[
1240,
25,
1264
],
[
1264,
... | [
[
[
"Methoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Methoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxapram"
],
[
... | Methoxamine may cause a moderate interaction that could exacerbate diseases when taken with Doxapram and Doxapram may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Methoxamine (Compound) resembles Midodrine (Compound) and Midodrine may cause a moderate interaction that could exa... |
DB08865 | DB11560 | 1,593 | 1,678 | [
"DDInter448",
"DDInter1038"
] | Crizotinib | Lesinurad | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Lesinurad is an oral uric acid transporter 1 (URAT1) inhibitor indicated for the treatment of hyperuricemia associated with gout. It reduces serum uric acid concentration through the inhibition of URAT1, an enzyme responsible for reuptake of uric acid from the renal tubule, and OAT4, another uric acid transporter assoc... | Moderate | 1 | [
[
[
1593,
24,
1678
]
],
[
[
1593,
23,
466
],
[
466,
63,
1678
]
],
[
[
1593,
64,
1374
],
[
1374,
24,
1678
]
],
[
[
1593,
63,
522
],
[
522,
... | [
[
[
"Crizotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lesinurad"
]
],
[
[
"Crizotinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
],
[
... | Crizotinib may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause a moderate interaction that could exacerbate diseases when taken with Lesinurad
Crizotinib may lead to a major life threatening interaction when taken with Abiraterone and Abiraterone may cau... |
DB01278 | DB06595 | 1,021 | 1,491 | [
"DDInter1506",
"DDInter1214"
] | Pramlintide | Midostaurin | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
1021,
24,
1491
]
],
[
[
1021,
63,
1148
],
[
1148,
24,
1491
]
],
[
[
1021,
24,
1399
],
[
1399,
63,
1491
]
],
[
[
1021,
24,
1254
],
[
12... | [
[
[
"Pramlintide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Pramlintide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
... | Pramlintide may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin
Pramlintide may cause a moderate interaction that could exacerbate diseases when taken with Lithium carbon... |
DB00697 | DB06595 | 876 | 1,491 | [
"DDInter1821",
"DDInter1214"
] | Tizanidine | Midostaurin | Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury. It may also be caused by musculoskeletal injury. Regardless of the cause, muscle spasticity can be an extremely painful and debili... | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
876,
24,
1491
]
],
[
[
876,
23,
112
],
[
112,
23,
1491
]
],
[
[
876,
63,
888
],
[
888,
24,
1491
]
],
[
[
876,
24,
1342
],
[
1342,
... | [
[
[
"Tizanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Tizanidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Tizanidine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Midostaurin
Tizanidine may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamo... |
DB01268 | DB08865 | 1,151 | 1,593 | [
"DDInter1731",
"DDInter448"
] | Sunitinib | Crizotinib | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Major | 2 | [
[
[
1151,
25,
1593
]
],
[
[
1151,
6,
2978
],
[
2978,
45,
1593
]
],
[
[
1151,
6,
8305
],
[
8305,
46,
1593
]
],
[
[
1151,
7,
6886
],
[
6886,... | [
[
[
"Sunitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
]
],
[
[
"Sunitinib",
"{u} (Compound) binds {v} (Gene)",
"MAP3K12"
],
[
"MAP3K12",
"{u} (Gene) is bound by {v} (Compound)",
"Crizoti... | Sunitinib (Compound) binds MAP3K12 (Gene) and MAP3K12 (Gene) is bound by Crizotinib (Compound)
Sunitinib (Compound) binds TLK2 (Gene) and TLK2 (Gene) is upregulated by Crizotinib (Compound)
Sunitinib (Compound) upregulates MSMO1 (Gene) and MSMO1 (Gene) is upregulated by Crizotinib (Compound)
Sunitinib (Compound) downre... |
DB01229 | DB11979 | 973 | 1,320 | [
"DDInter1378",
"DDInter625"
] | Paclitaxel (protein-bound) | Elagolix | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
973,
24,
1320
]
],
[
[
973,
63,
168
],
[
168,
23,
1320
]
],
[
[
973,
63,
79
],
[
79,
24,
1320
]
],
[
[
973,
24,
129
],
[
129,
24... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Elagolix
Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Elagolix
Paclitaxel may c... |
DB00206 | DB01168 | 1,245 | 1,053 | [
"DDInter1582",
"DDInter1526"
] | Reserpine | Procarbazine | An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a rese... | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Moderate | 1 | [
[
[
1245,
24,
1053
]
],
[
[
1245,
21,
28762
],
[
28762,
60,
1053
]
],
[
[
1245,
24,
104
],
[
104,
24,
1053
]
],
[
[
1245,
63,
1648
],
[
16... | [
[
[
"Reserpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
]
],
[
[
"Reserpine",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is caused... | Reserpine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Procarbazine (Compound)
Reserpine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Proca... |
DB01001 | DB01324 | 688 | 178 | [
"DDInter1632",
"DDInter1490"
] | Salbutamol | Polythiazide | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Moderate | 1 | [
[
[
688,
24,
178
]
],
[
[
688,
24,
674
],
[
674,
40,
178
]
],
[
[
688,
63,
504
],
[
504,
40,
178
]
],
[
[
688,
21,
28835
],
[
28835,
... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polythiazide"
]
],
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trichlormethiazide"
]... | Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Trichlormethiazide and Trichlormethiazide (Compound) resembles Polythiazide (Compound)
Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Hydrochlorothiazide and Hydrochlorothiazide (Compou... |
DB06704 | DB10276 | 247 | 1,624 | [
"DDInter952",
"DDInter1623"
] | Iobenguane (I-131) | Rotavirus vaccine | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Major | 2 | [
[
[
247,
25,
1624
]
],
[
[
247,
7,
6952
],
[
6952,
46,
77
],
[
77,
25,
1624
]
],
[
[
247,
18,
7359
],
[
7359,
57,
147
],
[
147,
25,
... | [
[
[
"Iobenguane",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Iobenguane",
"{u} (Compound) upregulates {v} (Gene)",
"MCOLN1"
],
[
"MCOLN1",
"{u} (Gene) is upregulated by {v} (Compoun... | Iobenguane may lead to a major life threatening interaction when taken with Rotavirus vaccine
Iobenguane (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Idarubicin (Compound) and Idarubicin may lead to a major life threatening interaction when taken with Rotavirus vaccine
Iobenguane (Compound) ... |
DB01041 | DB01098 | 770 | 14 | [
"DDInter1789",
"DDInter1622"
] | Thalidomide | Rosuvastatin | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin... | Moderate | 1 | [
[
[
770,
24,
14
]
],
[
[
770,
24,
671
],
[
671,
24,
14
]
],
[
[
770,
6,
7524
],
[
7524,
45,
14
]
],
[
[
770,
7,
3163
],
[
3163,
46,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rosuvastatin"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
],
... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin
Thalidomide (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Rosuvastatin (Compound)
Thalidomid... |
DB00065 | DB09115 | 581 | 505 | [
"DDInter923",
"DDInter559"
] | Infliximab | Diiodohydroxyquinoline | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Diiodohydroxyquinoline, also known as uidoquinol and iodoquinol, is a quinoline derivative that can be used in the treatment of amoebiasis. The exact mechanism of action is unknown. Iodoquinol is not currently available in any FDA-approved products. | Moderate | 1 | [
[
[
581,
24,
505
]
],
[
[
581,
24,
1593
],
[
1593,
24,
505
]
],
[
[
581,
25,
908
],
[
908,
24,
505
]
],
[
[
581,
24,
1434
],
[
1434,
... | [
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diiodohydroxyquinoline"
]
],
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
... | Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Diiodohydroxyquinoline
Infliximab may lead to a major life threatening interaction when taken with Golimumab and Golimumab ... |
DB00063 | DB00991 | 366 | 97 | [
"DDInter659",
"DDInter1358"
] | Eptifibatide | Oxaprozin | Synthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation. Derived from venom of the Southeastern pygmy rattlesnake (Sistrurus miliarus barbouri), eptifibatide is a cyclic heptapeptide that belongs to the class of arginin-glycin-aspartat-mimetics. | Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. | Moderate | 1 | [
[
[
366,
24,
97
]
],
[
[
366,
24,
1274
],
[
1274,
24,
97
]
],
[
[
366,
24,
998
],
[
998,
1,
97
]
],
[
[
366,
25,
936
],
[
936,
63,
... | [
[
[
"Eptifibatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaprozin"
]
],
[
[
"Eptifibatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
],
... | Eptifibatide may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Oxaprozin
Eptifibatide may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutazone... |
DB00026 | DB14762 | 1,184 | 994 | [
"DDInter94",
"DDInter1602"
] | Anakinra | Risankizumab | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Risankizumab is a fully humanized IgG1 monoclonal antibody (mAb) directed against interleukin 23 (IL-23). It gained its first global approval in Japan in March 2019, followed by approval in Canada, the US, and Europe in April 2019. Risankizumab is used to treat plaque psoriasis, psoriatic arthritis, and Crohn's disease... | Moderate | 1 | [
[
[
1184,
24,
994
]
],
[
[
1184,
23,
1114
],
[
1114,
23,
994
]
],
[
[
1184,
24,
4
],
[
4,
24,
994
]
],
[
[
1184,
24,
287
],
[
287,
6... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risankizumab"
]
],
[
[
"Anakinra",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc sulfate"
],
[
... | Anakinra may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Risankizumab
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccina... |
DB01124 | DB06414 | 1,411 | 655 | [
"DDInter1828",
"DDInter703"
] | Tolbutamide | Etravirine | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Moderate | 1 | [
[
[
1411,
24,
655
]
],
[
[
1411,
6,
6017
],
[
6017,
45,
655
]
],
[
[
1411,
21,
28680
],
[
28680,
60,
655
]
],
[
[
1411,
63,
1101
],
[
1101... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
]
],
[
[
"Tolbutamide",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)... | Tolbutamide (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Etravirine (Compound)
Tolbutamide (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Etravirine (Compound)
Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene ... |
DB01124 | DB01320 | 1,411 | 651 | [
"DDInter1828",
"DDInter783"
] | Tolbutamide | Fosphenytoin | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Moderate | 1 | [
[
[
1411,
24,
651
]
],
[
[
1411,
63,
362
],
[
362,
1,
651
]
],
[
[
1411,
6,
6017
],
[
6017,
45,
651
]
],
[
[
1411,
21,
28784
],
[
28784,
... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
[... | Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Compound)
Tolbutamide (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Fosphenytoin (Compound)
Tolbutamide (Compound) causes Thrombocytopenia (Side Effect) a... |
DB00675 | DB11853 | 888 | 230 | [
"DDInter1744",
"DDInter1577"
] | Tamoxifen | Relugolix | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Relugolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist used in the treatment of several hormone-responsive conditions. It was first approved in Japan in 2019, under the brand name Relumina, for the symptomatic treatment of uterine fibroids, and more recently by the United States' FDA in 2020, under th... | Moderate | 1 | [
[
[
888,
24,
230
]
],
[
[
888,
24,
129
],
[
129,
23,
230
]
],
[
[
888,
23,
112
],
[
112,
23,
230
]
],
[
[
888,
63,
1101
],
[
1101,
2... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Relugolix"
]
],
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
[
... | Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Relugolix
Tamoxifen may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metron... |
DB00023 | DB09389 | 305 | 517 | [
"DDInter127",
"DDInter1315"
] | Asparaginase Escherichia coli | Norgestrel | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Norgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantiomer ([levonorgestrel]) is biologically active. | Moderate | 1 | [
[
[
305,
24,
517
]
],
[
[
305,
24,
1130
],
[
1130,
23,
517
]
],
[
[
305,
24,
52
],
[
52,
24,
517
]
],
[
[
305,
24,
159
],
[
159,
63,... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norgestrel"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Pioglitazone and Pioglitazone may cause a minor interaction that can limit clinical effects when taken with Norgestrel
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseas... |
DB06077 | DB06210 | 879 | 72 | [
"DDInter1102",
"DDInter631"
] | Lumateperone | Eltrombopag | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelet... | Moderate | 1 | [
[
[
879,
24,
72
]
],
[
[
879,
25,
384
],
[
384,
63,
72
]
],
[
[
879,
24,
1619
],
[
1619,
63,
72
]
],
[
[
879,
64,
1419
],
[
1419,
24... | [
[
[
"Lumateperone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eltrombopag"
]
],
[
[
"Lumateperone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idelalisib"
],
[
"Idela... | Lumateperone may lead to a major life threatening interaction when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Eltrombopag
Lumateperone may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may cau... |
DB00619 | DB01096 | 1,419 | 678 | [
"DDInter909",
"DDInter1356"
] | Imatinib | Oxamniquine | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martidale, The Ex... | Moderate | 1 | [
[
[
1419,
24,
678
]
],
[
[
1419,
6,
12523
],
[
12523,
45,
678
]
],
[
[
1419,
24,
211
],
[
211,
23,
678
]
],
[
[
1419,
23,
479
],
[
479,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxamniquine"
]
],
[
[
"Imatinib",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
... | Imatinib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Oxamniquine (Compound)
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine and Tolterodine may cause a minor interaction that can limit clinical effects when taken with Oxamniquine
Imatinib may cause a... |
DB00446 | DB00532 | 597 | 208 | [
"DDInter351",
"DDInter1152"
] | Chloramphenicol | Mephenytoin | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subuni... | Moderate | 1 | [
[
[
597,
24,
208
]
],
[
[
597,
63,
168
],
[
168,
23,
208
]
],
[
[
597,
24,
1096
],
[
1096,
62,
208
]
],
[
[
597,
24,
908
],
[
908,
6... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mephenytoin"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Mephenytoin
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic... |
DB00615 | DB13074 | 690 | 877 | [
"DDInter1589",
"DDInter1110"
] | Rifabutin | Macimorelin | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Moderate | 1 | [
[
[
690,
24,
877
]
],
[
[
690,
24,
112
],
[
112,
23,
877
]
],
[
[
690,
24,
1320
],
[
1320,
24,
877
]
],
[
[
690,
25,
1019
],
[
1019,
... | [
[
[
"Rifabutin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Macimorelin"
]
],
[
[
"Rifabutin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elago... |
DB00196 | DB08868 | 600 | 1,011 | [
"DDInter743",
"DDInter737"
] | Fluconazole | Fingolimod | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
600,
25,
1011
]
],
[
[
600,
6,
8374
],
[
8374,
45,
1011
]
],
[
[
600,
21,
28792
],
[
28792,
60,
1011
]
],
[
[
600,
23,
1247
],
[
1247,... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Fluconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Fingo... | Fluconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fingolimod (Compound)
Fluconazole (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Fingolimod (Compound)
Fluconazole may cause a minor interaction that can limit clinical effects wh... |
DB05773 | DB08827 | 1,047 | 990 | [
"DDInter1848",
"DDInter1085"
] | Trastuzumab emtansine | Lomitapide | Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent, DM1. T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-mic... | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Major | 2 | [
[
[
1047,
25,
990
]
],
[
[
1047,
63,
1080
],
[
1080,
1,
990
]
],
[
[
1047,
25,
1409
],
[
1409,
24,
990
]
],
[
[
1047,
63,
973
],
[
973,
... | [
[
[
"Trastuzumab emtansine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomitapide"
]
],
[
[
"Trastuzumab emtansine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Conivaptan"
],
... | Trastuzumab emtansine may cause a moderate interaction that could exacerbate diseases when taken with Conivaptan and Conivaptan (Compound) resembles Lomitapide (Compound)
Trastuzumab emtansine may lead to a major life threatening interaction when taken with Apixaban and Apixaban may cause a moderate interaction that co... |
DB00845 | DB01254 | 1,490 | 1,213 | [
"DDInter406",
"DDInter484"
] | Clofazimine | Dasatinib | Clofazimine is a highly lipophilic antimicrobial riminophenazine dye used in combination with other agents, such as [dapsone], for the treatment of leprosy. It was originally described in 1957 and was the prototypical riminophenazine dye - a bright-red dye that, in its clinical use, results in long-lasting discoloratio... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
1490,
24,
1213
]
],
[
[
1490,
6,
4973
],
[
4973,
45,
1213
]
],
[
[
1490,
18,
16974
],
[
16974,
57,
1213
]
],
[
[
1490,
21,
28882
],
[
... | [
[
[
"Clofazimine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Clofazimine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Clofazimine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dasatinib (Compound)
Clofazimine (Compound) downregulates TUBB6 (Gene) and TUBB6 (Gene) is downregulated by Dasatinib (Compound)
Clofazimine (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is c... |
DB00549 | DB08860 | 522 | 788 | [
"DDInter1955",
"DDInter1479"
] | Zafirlukast | Pitavastatin | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the statin class of medications. By inhibiting the endogenous production of cholesterol within the liver, statins lower abnormal cholesterol and lipid levels and ultimately reduce the risk of cardiovascular disease. More sp... | Moderate | 1 | [
[
[
522,
24,
788
]
],
[
[
522,
24,
671
],
[
671,
1,
788
]
],
[
[
522,
24,
700
],
[
700,
40,
788
]
],
[
[
522,
6,
17404
],
[
17404,
4... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
]
],
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
],
... | Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin (Compound) resembles Pitavastatin (Compound)
Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Atorvastatin and Atorvastatin (Compound) resembles Pitavastatin... |
DB01324 | DB09112 | 178 | 1,455 | [
"DDInter1490",
"DDInter1306"
] | Polythiazide | Nitrous acid | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Nitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. There is also research to investigate its applica... | Moderate | 1 | [
[
[
178,
24,
1455
]
],
[
[
178,
1,
674
],
[
674,
24,
1455
]
],
[
[
178,
24,
1450
],
[
1450,
24,
1455
]
],
[
[
178,
63,
885
],
[
885,
... | [
[
[
"Polythiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nitrous acid"
]
],
[
[
"Polythiazide",
"{u} (Compound) resembles {v} (Compound)",
"Trichlormethiazide"
],
[
"Trichlormethiazide",
"{... | Polythiazide (Compound) resembles Trichlormethiazide (Compound) and Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with Nitrous acid
Polythiazide may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may cause a mod... |
DB01181 | DB06700 | 1,532 | 643 | [
"DDInter906",
"DDInter511"
] | Ifosfamide | Desvenlafaxine | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of ad... | Moderate | 1 | [
[
[
1532,
24,
643
]
],
[
[
1532,
63,
1100
],
[
1100,
1,
643
]
],
[
[
1532,
6,
8374
],
[
8374,
45,
643
]
],
[
[
1532,
21,
28709
],
[
28709,... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desvenlafaxine"
]
],
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venlafaxine"
],
... | Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine (Compound) resembles Desvenlafaxine (Compound)
Ifosfamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Desvenlafaxine (Compound)
Ifosfamide (Compound) causes Decreased appetite (Side Ef... |
DB00099 | DB06810 | 440 | 397 | [
"DDInter735",
"DDInter1484"
] | Filgrastim | Plicamycin | Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the seq... | Plicamycin is an antineoplastic antibiotic produced by Streptomyces plicatus. It has been used in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of hypercalcemia. The manufacturer discontinued plicamycin in 2000. | Moderate | 1 | [
[
[
440,
24,
397
]
],
[
[
440,
24,
384
],
[
384,
63,
397
]
],
[
[
440,
24,
869
],
[
869,
24,
397
]
],
[
[
440,
63,
599
],
[
599,
24,... | [
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Plicamycin"
]
],
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
[
... | Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Plicamycin
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Topotecan and Topotec... |
DB00005 | DB06186 | 1,057 | 1,439 | [
"DDInter687",
"DDInter969"
] | Etanercept | Ipilimumab | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes.[A35065,A35080,L12126] Ipilimumab was developed by Bristol-Myers Squibb and Medarex. Ipilimumab was granted FDA approva... | Moderate | 1 | [
[
[
1057,
24,
1439
]
],
[
[
1057,
25,
617
],
[
617,
24,
1439
]
],
[
[
1057,
25,
1060
],
[
1060,
63,
1439
]
],
[
[
1057,
24,
268
],
[
268,
... | [
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ipilimumab"
]
],
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Budesonide"
],
[
"Budesonide... | Etanercept may lead to a major life threatening interaction when taken with Budesonide and Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Ipilimumab
Etanercept may lead to a major life threatening interaction when taken with Enfortumab vedotin and Enfortumab vedotin may cause... |
DB00468 | DB00472 | 1,424 | 758 | [
"DDInter1557",
"DDInter758"
] | Quinine | Fluoxetine | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Moderate | 1 | [
[
[
1424,
24,
758
]
],
[
[
1424,
63,
847
],
[
847,
1,
758
]
],
[
[
1424,
24,
109
],
[
109,
40,
758
]
],
[
[
1424,
6,
12523
],
[
12523,
... | [
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxetine"
]
],
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atomoxetine"
],
[
"... | Quinine may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine (Compound) resembles Fluoxetine (Compound)
Quinine may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxetine (Compound) resembles Fluoxetine (Compound)
Quin... |
DB01001 | DB11057 | 688 | 720 | [
"DDInter1632",
"DDInter1223"
] | Salbutamol | Mineral oil | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
688,
24,
720
]
],
[
[
688,
24,
927
],
[
927,
63,
720
]
],
[
[
688,
62,
175
],
[
175,
24,
720
]
],
[
[
688,
24,
1151
],
[
1151,
2... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
],
[
... | Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Salbutamol may cause a minor interaction that can limit clinical effects when taken with Triamcinolone and Tr... |
DB00382 | DB01075 | 62 | 1,376 | [
"DDInter1734",
"DDInter569"
] | Tacrine | Diphenhydramine | A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market. | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
62,
24,
1376
]
],
[
[
62,
24,
11
],
[
11,
1,
1376
]
],
[
[
62,
24,
128
],
[
128,
24,
1376
]
],
[
[
62,
63,
1594
],
[
1594,
24,
... | [
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Toremifene"
],
[
... | Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Toremifene and Toremifene (Compound) resembles Diphenhydramine (Compound)
Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine and Dexbrompheniramine may cause a moderate interac... |
DB00352 | DB12141 | 482 | 971 | [
"DDInter1814",
"DDInter817"
] | Tioguanine | Gilteritinib | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
482,
24,
971
]
],
[
[
482,
24,
1247
],
[
1247,
23,
971
]
],
[
[
482,
24,
72
],
[
72,
24,
971
]
],
[
[
482,
63,
847
],
[
847,
24,... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfamethoxazole"
],
... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Eltrombop... |
DB01406 | DB12141 | 984 | 971 | [
"DDInter472",
"DDInter817"
] | Danazol | Gilteritinib | A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
984,
24,
971
]
],
[
[
984,
25,
1135
],
[
1135,
23,
971
]
],
[
[
984,
63,
1645
],
[
1645,
24,
971
]
],
[
[
984,
24,
1297
],
[
1297,
... | [
[
[
"Danazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Danazol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
... | Danazol may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Danazol may cause a moderate interaction that could exacerbate diseases when taken with Metformin and Metformin may cause a moderate... |
DB00831 | DB06691 | 1,178 | 849 | [
"DDInter1866",
"DDInter1155"
] | Trifluoperazine | Mepyramine | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
1178,
24,
849
]
],
[
[
1178,
63,
1594
],
[
1594,
24,
849
]
],
[
[
1178,
24,
272
],
[
272,
24,
849
]
],
[
[
1178,
6,
10104
],
[
10104,
... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
]... | Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Chlorphenir... |
DB01764 | DB06772 | 805 | 310 | [
"DDInter469",
"DDInter259"
] | Dalfopristin | Cabazitaxel | Dalfopristin is a combination of two antibiotics (Dalfopristin and quinupristin) used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. It is not effective against Enterococcus faecalis infections. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome ... | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Moderate | 1 | [
[
[
805,
24,
310
]
],
[
[
805,
63,
973
],
[
973,
24,
310
]
],
[
[
805,
6,
8374
],
[
8374,
45,
310
]
],
[
[
805,
24,
351
],
[
351,
63... | [
[
[
"Dalfopristin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
]
],
[
[
"Dalfopristin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
],
... | Dalfopristin may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel
Dalfopristin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cabazitaxel (Compound)
Dalfopristin... |
DB00928 | DB11601 | 1,426 | 1,270 | [
"DDInter148",
"DDInter1889"
] | Azacitidine | Tuberculin purified protein derivative | Azacitidine is a pyrimidine nucleoside analogue with anti-neoplastic activity. It differs from cytosine by the presence of nitrogen in the C5-position, key in its hypomethylating activity.[A1406,A1413,A1415] Two main mechanisms of action have been proposed for azacitidine. One of them is the induction of cytotoxicity. ... | Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The diagnostic test is commonly referred to as the Mantoux test which serves to minimize the risk of transmission of infection with *Mycoba... | Moderate | 1 | [
[
[
1426,
24,
1270
]
],
[
[
1426,
24,
1531
],
[
1531,
24,
1270
]
],
[
[
1426,
64,
1064
],
[
1064,
24,
1270
]
],
[
[
1426,
63,
599
],
[
599... | [
[
[
"Azacitidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protein derivative"
]
],
[
[
"Azacitidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Azacitidine may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab and Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative
Azacitidine may lead to a major life threatening interaction when taken with Clad... |
DB00023 | DB00749 | 305 | 59 | [
"DDInter127",
"DDInter699"
] | Asparaginase Escherichia coli | Etodolac | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. | Moderate | 1 | [
[
[
305,
24,
59
]
],
[
[
305,
24,
372
],
[
372,
24,
59
]
],
[
[
305,
24,
848
],
[
848,
63,
59
]
],
[
[
305,
25,
976
],
[
976,
63,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etodolac"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}"... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Etodolac
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases... |
DB00333 | DB00572 | 576 | 85 | [
"DDInter1166",
"DDInter136"
] | Methadone | Atropine | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Moderate | 1 | [
[
[
576,
24,
85
]
],
[
[
576,
24,
19
],
[
19,
24,
85
]
],
[
[
576,
25,
1166
],
[
1166,
40,
85
]
],
[
[
576,
6,
7950
],
[
7950,
45,
... | [
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atropine"
]
],
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
[
... | Methadone may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Atropine
Methadone may lead to a major life threatening interaction when taken with Dolasetron and Dolasetron (Compound) r... |
DB00981 | DB11363 | 1,528 | 1,276 | [
"DDInter1462",
"DDInter39"
] | Physostigmine | Alectinib | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase. It is specifically used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein-like 4) fusion protein that causes prol... | Moderate | 1 | [
[
[
1528,
24,
1276
]
],
[
[
1528,
24,
819
],
[
819,
24,
1276
]
],
[
[
1528,
63,
190
],
[
190,
24,
1276
]
],
[
[
1528,
24,
1476
],
[
1476,
... | [
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alectinib"
]
],
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acebutolol"
],
... | Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Acebutolol and Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Alectinib
Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Succinylcholine ... |
DB09074 | DB15328 | 1,362 | 829 | [
"DDInter1327",
"DDInter1896"
] | Olaparib | Ubrogepant | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Ubrogepant is indicated for the acute treatment of migraine headaches with or without aura in adults. It was approved by the FDA on December 23, 2019, and is the first oral calcitonin gene-related peptide (CGRP) receptor antagonist approved for the acute treatment of migraine. Several oral small molecule CGRP receptor ... | Moderate | 1 | [
[
[
1362,
24,
829
]
],
[
[
1362,
63,
1468
],
[
1468,
24,
829
]
],
[
[
1362,
64,
1593
],
[
1593,
24,
829
]
],
[
[
1362,
24,
484
],
[
484,
... | [
[
[
"Olaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ubrogepant"
]
],
[
[
"Olaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
],
[
"... | Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Ubrogepant
Olaparib may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a mode... |
DB00635 | DB01122 | 1,573 | 158 | [
"DDInter1515",
"DDInter61"
] | Prednisone | Ambenonium | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Ambenonium is a cholinesterase inhibitor. It is used in the management of myasthenia gravis. | Moderate | 1 | [
[
[
1573,
24,
158
]
],
[
[
1573,
40,
870
],
[
870,
24,
158
]
],
[
[
1573,
25,
1011
],
[
1011,
63,
158
]
],
[
[
1573,
25,
770
],
[
770,
... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ambenonium"
]
],
[
[
"Prednisone",
"{u} (Compound) resembles {v} (Compound)",
"Fludrocortisone"
],
[
"Fludrocortisone",
"{u} may cause... | Prednisone (Compound) resembles Fludrocortisone (Compound) and Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Ambenonium
Prednisone may lead to a major life threatening interaction when taken with Fingolimod and Fingolimod may cause a moderate interaction that could exac... |
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