drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00366 | DB00395 | 1,594 | 210 | [
"DDInter600",
"DDInter301"
] | Doxylamine | Carisoprodol | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Originally approved by the FDA in 1959 [FDA label], carisoprodol is a centrally acting muscle relaxant used in painful musculoskeletal conditions in conjunction with physical therapy and other medications . This drug is available by itself in an oral tablet or combined with aspirin, or in a fixed-dose combination with ... | Moderate | 1 | [
[
[
1594,
24,
210
]
],
[
[
1594,
24,
1050
],
[
1050,
40,
210
]
],
[
[
1594,
21,
28751
],
[
28751,
60,
210
]
],
[
[
1594,
74,
701
],
[
701,... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carisoprodol"
]
],
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meprobamate"
],
[... | Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Meprobamate and Meprobamate (Compound) resembles Carisoprodol (Compound)
Doxylamine (Compound) causes Convulsion (Side Effect) and Convulsion (Side Effect) is caused by Carisoprodol (Compound)
Doxylamine (Compound) resembles Clem... |
DB01344 | DB11093 | 1,231 | 636 | [
"DDInter1830",
"DDInter273"
] | Tolevamer | Calcium citrate | Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines. It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among others, H... | Calcium citrate is a salt typically used as a source of calcium in a variety of over the counter supplements. | Moderate | 1 | [
[
[
1231,
24,
636
]
],
[
[
1231,
24,
1482
],
[
1482,
24,
636
]
],
[
[
1231,
63,
1252
],
[
1252,
24,
636
]
],
[
[
1231,
25,
115
],
[
115,
... | [
[
[
"Tolevamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium citrate"
]
],
[
[
"Tolevamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digitoxin"
],
[
... | Tolevamer may cause a moderate interaction that could exacerbate diseases when taken with Digitoxin and Digitoxin may cause a moderate interaction that could exacerbate diseases when taken with Calcium citrate
Tolevamer may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin ... |
DB01611 | DB09078 | 1,487 | 1,228 | [
"DDInter893",
"DDInter1036"
] | Hydroxychloroquine | Lenvatinib | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Major | 2 | [
[
[
1487,
25,
1228
]
],
[
[
1487,
63,
112
],
[
112,
23,
1228
]
],
[
[
1487,
62,
1247
],
[
1247,
23,
1228
]
],
[
[
1487,
64,
1100
],
[
1100... | [
[
[
"Hydroxychloroquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lenvatinib"
]
],
[
[
"Hydroxychloroquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lenvatinib
Hydroxychloroquine may cause a minor interaction that can limit clinical effects when taken with Sul... |
DB00307 | DB11837 | 1,101 | 1,297 | [
"DDInter202",
"DDInter1351"
] | Bexarotene | Osilodrostat | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
1101,
24,
1297
]
],
[
[
1101,
24,
1135
],
[
1135,
23,
1297
]
],
[
[
1101,
24,
466
],
[
466,
62,
1297
]
],
[
[
1101,
23,
271
],
[
271,
... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
[
... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolu... |
DB00059 | DB00554 | 1,560 | 1,027 | [
"DDInter1404",
"DDInter1478"
] | Pegaspargase | Piroxicam | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. | Moderate | 1 | [
[
[
1560,
24,
1027
]
],
[
[
1560,
24,
1171
],
[
1171,
1,
1027
]
],
[
[
1560,
24,
959
],
[
959,
63,
1027
]
],
[
[
1560,
25,
976
],
[
976,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Piroxicam"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meloxicam"
],
[
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Meloxicam and Meloxicam (Compound) resembles Piroxicam (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could ... |
DB09036 | DB14881 | 812 | 180 | [
"DDInter1668",
"DDInter1329"
] | Siltuximab | Oliceridine | Siltuximab is a chimeric (human-mouse) monoclonal immunoglobulin G1-kappa antibody produced in a Chinese hamster ovary (CHO) cell line by recombinant DNA technology. Siltuximab prevents the binding of IL-6 to soluble and membrane-bound IL-6 receptors by forming high affinity complexes with human interleukin-6 (IL-6). I... | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Moderate | 1 | [
[
[
812,
24,
180
]
],
[
[
812,
63,
1184
],
[
1184,
24,
180
]
],
[
[
812,
64,
375
],
[
375,
24,
180
]
],
[
[
812,
25,
1259
],
[
1259,
... | [
[
[
"Siltuximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oliceridine"
]
],
[
[
"Siltuximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anakinra"
],
[
... | Siltuximab may cause a moderate interaction that could exacerbate diseases when taken with Anakinra and Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Oliceridine
Siltuximab may lead to a major life threatening interaction when taken with Certolizumab pegol and Certolizumab peg... |
DB00006 | DB01105 | 942 | 222 | [
"DDInter217",
"DDInter1665"
] | Bivalirudin | Sibutramine | Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important t... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
942,
24,
222
]
],
[
[
942,
25,
802
],
[
802,
63,
222
]
],
[
[
942,
24,
1027
],
[
1027,
24,
222
]
],
[
[
942,
25,
126
],
[
126,
2... | [
[
[
"Bivalirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Bivalirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tinzaparin"
],
[
"Tinzapa... | Bivalirudin may lead to a major life threatening interaction when taken with Tinzaparin and Tinzaparin may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Piroxicam and Piroxicam may cause... |
DB00574 | DB06754 | 121 | 707 | [
"DDInter717",
"DDInter471"
] | Fenfluramine | Danaparoid | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans . The active constituents are heparan, dermatan and , and they are isolated from the porcine intestinal mucosa [FDA Label]. Danaparoid possesses a potent antithrombic activity t... | Moderate | 1 | [
[
[
121,
24,
707
]
],
[
[
121,
25,
41
],
[
41,
63,
707
]
],
[
[
121,
25,
901
],
[
901,
24,
707
]
],
[
[
121,
64,
1100
],
[
1100,
24,... | [
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Danaparoid"
]
],
[
[
"Fenfluramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Levomilnacipran"
],
[
"L... | Fenfluramine may lead to a major life threatening interaction when taken with Levomilnacipran and Levomilnacipran may cause a moderate interaction that could exacerbate diseases when taken with Danaparoid
Fenfluramine may lead to a major life threatening interaction when taken with Milnacipran and Milnacipran may cause... |
DB00387 | DB00761 | 1,386 | 1,621 | [
"DDInter1528",
"DDInter1497"
] | Procyclidine | Potassium chloride | A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism. | A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of potassium p... | Major | 2 | [
[
[
1386,
25,
1621
]
],
[
[
1386,
40,
1105
],
[
1105,
25,
1621
]
],
[
[
1386,
24,
13
],
[
13,
25,
1621
]
],
[
[
1386,
24,
100
],
[
100,
... | [
[
[
"Procyclidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Potassium chloride"
]
],
[
[
"Procyclidine",
"{u} (Compound) resembles {v} (Compound)",
"Trihexyphenidyl"
],
[
"Trihexyphenidyl",
"{u} may lead to ... | Procyclidine (Compound) resembles Trihexyphenidyl (Compound) and Trihexyphenidyl may lead to a major life threatening interaction when taken with Potassium chloride
Procyclidine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may lead to a major life thr... |
DB06704 | DB09156 | 247 | 777 | [
"DDInter952",
"DDInter964"
] | Iobenguane (I-131) | Iopromide | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the flow path of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs. Although iopromide can... | Major | 2 | [
[
[
247,
25,
777
]
],
[
[
247,
64,
772
],
[
772,
24,
777
]
],
[
[
247,
24,
242
],
[
242,
63,
777
]
],
[
[
247,
76,
1523
],
[
1523,
2... | [
[
[
"Iobenguane",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iopromide"
]
],
[
[
"Iobenguane",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Carvedilol"
],
[
"Carvedilol",
"{u} ma... | Iobenguane may lead to a major life threatening interaction when taken with Iopromide
Iobenguane may lead to a major life threatening interaction when taken with Carvedilol and Carvedilol may cause a moderate interaction that could exacerbate diseases when taken with Iopromide
Iobenguane may cause a moderate interactio... |
DB00960 | DB06704 | 887 | 247 | [
"DDInter1471",
"DDInter952"
] | Pindolol | Iobenguane (I-131) | Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the earl... | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Major | 2 | [
[
[
887,
25,
247
]
],
[
[
887,
18,
8109
],
[
8109,
57,
247
]
],
[
[
887,
21,
28787
],
[
28787,
60,
247
]
],
[
[
887,
24,
820
],
[
820,
... | [
[
[
"Pindolol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iobenguane"
]
],
[
[
"Pindolol",
"{u} (Compound) downregulates {v} (Gene)",
"NVL"
],
[
"NVL",
"{u} (Gene) is downregulated by {v} (Compound)",
"I... | Pindolol may lead to a major life threatening interaction when taken with Iobenguane
Pindolol (Compound) downregulates NVL (Gene) and NVL (Gene) is downregulated by Iobenguane (Compound)
Pindolol (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Iobenguane (Compound)
Pindolol may caus... |
DB00334 | DB01156 | 867 | 593 | [
"DDInter1326",
"DDInter252"
] | Olanzapine | Bupropion | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Major | 2 | [
[
[
867,
25,
593
]
],
[
[
867,
6,
8374
],
[
8374,
45,
593
]
],
[
[
867,
10,
11621
],
[
11621,
49,
593
]
],
[
[
867,
7,
8953
],
[
8953,
... | [
[
[
"Olanzapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bupropion"
]
],
[
[
"Olanzapine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Bupropio... | Olanzapine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bupropion (Compound)
Olanzapine (Compound) palliates panic disorder (Disease) and panic disorder (Disease) is palliated by Bupropion (Compound)
Olanzapine (Compound) upregulates NNT (Gene) and NNT (Gene) is downregulated by Bupropion (Compound)
Ola... |
DB00444 | DB01610 | 63 | 248 | [
"DDInter1765",
"DDInter1912"
] | Teniposide | Valganciclovir | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases. | Moderate | 1 | [
[
[
63,
24,
248
]
],
[
[
63,
24,
563
],
[
563,
1,
248
]
],
[
[
63,
21,
29209
],
[
29209,
60,
248
]
],
[
[
63,
24,
1480
],
[
1480,
63... | [
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valganciclovir"
]
],
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ganciclovir"
],
... | Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Ganciclovir and Ganciclovir (Compound) resembles Valganciclovir (Compound)
Teniposide (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Valganciclovir (Compound)
Teniposide may cause a moderate inte... |
DB00451 | DB00615 | 542 | 690 | [
"DDInter1064",
"DDInter1589"
] | Levothyroxine | Rifabutin | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Moderate | 1 | [
[
[
542,
24,
690
]
],
[
[
542,
24,
463
],
[
463,
1,
690
]
],
[
[
542,
6,
8374
],
[
8374,
45,
690
]
],
[
[
542,
18,
2183
],
[
2183,
5... | [
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifabutin"
]
],
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifampicin"
],
... | Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Rifampicin and Rifampicin (Compound) resembles Rifabutin (Compound)
Levothyroxine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rifabutin (Compound)
Levothyroxine (Compound) downregulates CDC20 (Gene) and CDC20 ... |
DB00630 | DB01592 | 1,485 | 1,596 | [
"DDInter42",
"DDInter975"
] | Alendronic acid | Iron | Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label]. | A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletio... | Moderate | 1 | [
[
[
1485,
24,
1596
]
],
[
[
1485,
21,
29276
],
[
29276,
60,
1596
]
],
[
[
1485,
24,
1193
],
[
1193,
62,
1596
]
],
[
[
1485,
62,
752
],
[
7... | [
[
[
"Alendronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron"
]
],
[
[
"Alendronic acid",
"{u} (Compound) causes {v} (Side Effect)",
"Haemoglobin"
],
[
"Haemoglobin",
"{u} (Side Effect)... | Alendronic acid (Compound) causes Haemoglobin (Side Effect) and Haemoglobin (Side Effect) is caused by Iron (Compound)
Alendronic acid may cause a moderate interaction that could exacerbate diseases when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when take... |
DB00342 | DB00701 | 1,181 | 1,091 | [
"DDInter1770",
"DDInter90"
] | Terfenadine | Amprenavir | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Amprenavir is a protease inhibitor used to treat HIV infection. | Major | 2 | [
[
[
1181,
25,
1091
]
],
[
[
1181,
25,
34
],
[
34,
1,
1091
]
],
[
[
1181,
64,
600
],
[
600,
23,
1091
]
],
[
[
1181,
24,
1374
],
[
1374,
... | [
[
[
"Terfenadine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amprenavir"
]
],
[
[
"Terfenadine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fosamprenavir"
],
[
"Fosamprenavir",
... | Terfenadine may lead to a major life threatening interaction when taken with Fosamprenavir and Fosamprenavir (Compound) resembles Amprenavir (Compound)
Terfenadine may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may cause a minor interaction that can limit clinical effects w... |
DB00060 | DB06403 | 912 | 1,204 | [
"DDInter947",
"DDInter62"
] | Interferon beta-1a | Ambrisentan | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Ambrisentan is an orally active selective type A endothelin receptor antagonist indicated for the treatment of pulmonary arterial hypertension. It is approved in Europe, Canada and the United States for use as a single agent to improve exercise ability and delay clinical worsening. In addition, it is approved in the Un... | Moderate | 1 | [
[
[
912,
24,
1204
]
],
[
[
912,
24,
600
],
[
600,
23,
1204
]
],
[
[
912,
24,
868
],
[
868,
63,
1204
]
],
[
[
912,
24,
478
],
[
478,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ambrisentan"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazol... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a minor interaction that can limit clinical effects when taken with Ambrisentan
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Vemu... |
DB00030 | DB00176 | 1,685 | 529 | [
"DDInter934",
"DDInter770"
] | Insulin human | Fluvoxamine | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | Moderate | 1 | [
[
[
1685,
24,
529
]
],
[
[
1685,
24,
1424
],
[
1424,
62,
529
]
],
[
[
1685,
24,
1220
],
[
1220,
63,
529
]
],
[
[
1685,
24,
1466
],
[
1466,... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvoxamine"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinine"
],
... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinine may cause a minor interaction that can limit clinical effects when taken with Fluvoxamine
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexa... |
DB00701 | DB08895 | 1,091 | 976 | [
"DDInter90",
"DDInter1825"
] | Amprenavir | Tofacitinib | Amprenavir is a protease inhibitor used to treat HIV infection. | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
1091,
25,
976
]
],
[
[
1091,
24,
214
],
[
214,
63,
976
]
],
[
[
1091,
25,
982
],
[
982,
63,
976
]
],
[
[
1091,
23,
86
],
[
86,
2... | [
[
[
"Amprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
],
[
"Fostama... | Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib
Amprenavir may lead to a major life threatening interaction when taken with Ivosidenib and Ivosidenib may c... |
DB06203 | DB09564 | 1,002 | 1,296 | [
"DDInter51",
"DDInter930"
] | Alogliptin | Insulin degludec | Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25,... | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
1002,
24,
1296
]
],
[
[
1002,
62,
1103
],
[
1103,
23,
1296
]
],
[
[
1002,
63,
1411
],
[
1411,
24,
1296
]
],
[
[
1002,
24,
659
],
[
659... | [
[
[
"Alogliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Alogliptin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
],
... | Alogliptin may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Insulin degludec
Alogliptin may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tol... |
DB01131 | DB09276 | 1,243 | 381 | [
"DDInter1531",
"DDInter1682"
] | Proguanil | Sodium aurothiomalate | Proguanil is a prophylactic antimalarial drug, which works by stopping the malaria parasite, _Plasmodium falciparum_ and _Plasmodium vivax_, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite. | Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in active progressive rheumatoid arthritis and of little or no valu... | Major | 2 | [
[
[
1243,
25,
381
]
],
[
[
1243,
63,
929
],
[
929,
25,
381
]
],
[
[
1243,
63,
126
],
[
126,
24,
1683
],
[
1683,
24,
381
]
],
[
[
1243,
... | [
[
[
"Proguanil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sodium aurothiomalate"
]
],
[
[
"Proguanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pyrimethamine"
],
[
... | Proguanil may cause a moderate interaction that could exacerbate diseases when taken with Pyrimethamine and Pyrimethamine may lead to a major life threatening interaction when taken with Sodium aurothiomalate
Proguanil may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin... |
DB00046 | DB00881 | 1,179 | 954 | [
"DDInter940",
"DDInter1554"
] | Insulin lispro | Quinapril | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure.[L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta b... | Moderate | 1 | [
[
[
1179,
24,
954
]
],
[
[
1179,
24,
1638
],
[
1638,
1,
954
]
],
[
[
1179,
24,
1523
],
[
1523,
40,
954
]
],
[
[
1179,
24,
251
],
[
251,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinapril"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trandolapril"
],... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril and Trandolapril (Compound) resembles Quinapril (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol (Compound) resembles Quinapril (Co... |
DB00515 | DB06372 | 589 | 259 | [
"DDInter387",
"DDInter1594"
] | Cisplatin | Rilonacept | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
589,
24,
259
]
],
[
[
589,
63,
1461
],
[
1461,
23,
259
]
],
[
[
589,
24,
0
],
[
0,
24,
259
]
],
[
[
589,
24,
1330
],
[
1330,
63,... | [
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Rilonacept
Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Dactinomycin and Dactinomyc... |
DB04837 | DB06691 | 649 | 849 | [
"DDInter407",
"DDInter1155"
] | Clofedanol | Mepyramine | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
649,
24,
849
]
],
[
[
649,
1,
11775
],
[
11775,
40,
849
]
],
[
[
649,
40,
11244
],
[
11244,
1,
849
]
],
[
[
649,
63,
1594
],
[
1594,
... | [
[
[
"Clofedanol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Clofedanol",
"{u} (Compound) resembles {v} (Compound)",
"Chloropyramine"
],
[
"Chloropyramine",
"{u} (Compound) ... | Clofedanol (Compound) resembles Chloropyramine (Compound) and Chloropyramine (Compound) resembles Mepyramine (Compound)
Clofedanol (Compound) resembles Pheniramine (Compound) and Pheniramine (Compound) resembles Mepyramine (Compound)
Clofedanol may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00658 | DB01583 | 965 | 624 | [
"DDInter1663",
"DDInter1075"
] | Sevelamer | Liotrix | Sevelamer is a phosphate binding drug used to prevent hyperphosphataemia in patients with chronic renal failure. It is marketed by Genzyme under the trade name Renagel. | Liotrix is a synthetically derived thyroid hormone replacement preparation. It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in a 4 to 1 ratio by weight. Liotrix was developed when it was believed that serum levels of both T4 and T3 were maintained by direct thyroidal s... | Moderate | 1 | [
[
[
965,
24,
624
]
],
[
[
965,
63,
1152
],
[
1152,
1,
624
]
],
[
[
965,
63,
542
],
[
542,
40,
624
]
],
[
[
965,
21,
28898
],
[
28898,
... | [
[
[
"Sevelamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liotrix"
]
],
[
[
"Sevelamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liothyronine"
],
[
... | Sevelamer may cause a moderate interaction that could exacerbate diseases when taken with Liothyronine and Liothyronine (Compound) resembles Liotrix (Compound)
Sevelamer may cause a moderate interaction that could exacerbate diseases when taken with Levothyroxine and Levothyroxine (Compound) resembles Liotrix (Compound... |
DB01364 | DB11827 | 22 | 433 | [
"DDInter650",
"DDInter669"
] | Ephedrine | Ertugliflozin | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
22,
24,
433
]
],
[
[
22,
63,
1121
],
[
1121,
24,
433
]
],
[
[
22,
74,
1466
],
[
1466,
24,
433
]
],
[
[
22,
40,
280
],
[
280,
24,... | [
[
[
"Ephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Ephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisoprolol"
],
[
... | Ephedrine may cause a moderate interaction that could exacerbate diseases when taken with Bisoprolol and Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Ephedrine (Compound) resembles Phenylpropanolamine (Compound) and Ephedrine may cause a moderate interaction t... |
DB06605 | DB12095 | 1,409 | 179 | [
"DDInter108",
"DDInter1760"
] | Apixaban | Telotristat ethyl | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Telotristat ethyl is a prodrug of telotristat that was approved by the FDA in March 2017 as Xermelo. It was previously referred to as telotristat etiprate, the hippurate salt form; however, the FDA recommends the use of the name of the neutral form rather than that of the salt.[A252937, A252942] Currently, telotristat ... | Moderate | 1 | [
[
[
1409,
24,
179
]
],
[
[
1409,
63,
79
],
[
79,
24,
179
]
],
[
[
1409,
24,
214
],
[
214,
24,
179
]
],
[
[
1409,
64,
1213
],
[
1213,
... | [
[
[
"Apixaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telotristat ethyl"
]
],
[
[
"Apixaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sorafenib"
],
[
... | Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Telotristat ethyl
Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fos... |
DB00491 | DB08869 | 127 | 162 | [
"DDInter1217",
"DDInter1773"
] | Miglitol | Tesamorelin | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | Tesamorelin is a stabilized synthetic peptide analogue of the hypothalamic peptide, Growth Hormone Releasing Hormone (GHRH) indicated for the reduction of excess abdominal fat in HIV-infected patients with lipodystrophy. Lipodystrophy is a metabolic condition characterized by insulin resistance, fat redistribution, and... | Moderate | 1 | [
[
[
127,
24,
162
]
],
[
[
127,
63,
245
],
[
245,
24,
162
]
],
[
[
127,
24,
1411
],
[
1411,
24,
162
]
],
[
[
127,
24,
1296
],
[
1296,
... | [
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tesamorelin"
]
],
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
[
... | Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Tesamorelin
Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbut... |
DB00264 | DB01240 | 88 | 885 | [
"DDInter1200",
"DDInter657"
] | Metoprolol | Epoprostenol | Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succi... | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Moderate | 1 | [
[
[
88,
24,
885
]
],
[
[
88,
24,
1061
],
[
1061,
1,
885
]
],
[
[
88,
21,
28936
],
[
28936,
60,
885
]
],
[
[
88,
24,
1512
],
[
1512,
... | [
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
]
],
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
... | Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil (Compound) resembles Epoprostenol (Compound)
Metoprolol (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Epoprostenol (Compound)
Metoprolol may cause a moder... |
DB00619 | DB12130 | 1,419 | 1,017 | [
"DDInter909",
"DDInter1094"
] | Imatinib | Lorlatinib | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
1419,
24,
1017
]
],
[
[
1419,
63,
608
],
[
608,
23,
1017
]
],
[
[
1419,
24,
1612
],
[
1612,
23,
1017
]
],
[
[
1419,
23,
271
],
[
271,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
"... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir and Fostemsavir m... |
DB00697 | DB01177 | 876 | 77 | [
"DDInter1821",
"DDInter904"
] | Tizanidine | Idarubicin | Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury. It may also be caused by musculoskeletal injury. Regardless of the cause, muscle spasticity can be an extremely painful and debili... | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Moderate | 1 | [
[
[
876,
24,
77
]
],
[
[
876,
18,
10780
],
[
10780,
57,
77
]
],
[
[
876,
21,
28931
],
[
28931,
60,
77
]
],
[
[
876,
23,
112
],
[
112,
... | [
[
[
"Tizanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idarubicin"
]
],
[
[
"Tizanidine",
"{u} (Compound) downregulates {v} (Gene)",
"CCNB2"
],
[
"CCNB2",
"{u} (Gene) is downregulated by {v... | Tizanidine (Compound) downregulates CCNB2 (Gene) and CCNB2 (Gene) is downregulated by Idarubicin (Compound)
Tizanidine (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Idarubicin (Compound)
Tizanidine may cause a minor interaction that can limit clinical effects when taken with Met... |
DB00502 | DB09020 | 1,300 | 28 | [
"DDInter853",
"DDInter212"
] | Haloperidol | Bisacodyl | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
1300,
24,
28
]
],
[
[
1300,
24,
662
],
[
662,
1,
28
]
],
[
[
1300,
63,
128
],
[
128,
40,
28
]
],
[
[
1300,
24,
272
],
[
272,
40,... | [
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
... | Haloperidol may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine (Compound) resembles Bisacodyl (Compound)
Haloperidol may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine and Dexbrompheniramine (Compound) resembles... |
DB00776 | DB06616 | 1,335 | 594 | [
"DDInter1360",
"DDInter224"
] | Oxcarbazepine | Bosutinib | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Moderate | 1 | [
[
[
1335,
24,
594
]
],
[
[
1335,
63,
883
],
[
883,
1,
594
]
],
[
[
1335,
6,
8374
],
[
8374,
45,
594
]
],
[
[
1335,
21,
29231
],
[
29231,
... | [
[
[
"Oxcarbazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
]
],
[
[
"Oxcarbazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
... | Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Bosutinib (Compound)
Oxcarbazepine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bosutinib (Compound)
Oxcarbazepine (Compound) causes Cardiac disorder (Side Effect) a... |
DB09122 | DB12141 | 1,613 | 971 | [
"DDInter1409",
"DDInter817"
] | Peginterferon beta-1a | Gilteritinib | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
1613,
24,
971
]
],
[
[
1613,
63,
1247
],
[
1247,
23,
971
]
],
[
[
1613,
63,
72
],
[
72,
24,
971
]
],
[
[
1613,
24,
242
],
[
242,
... | [
[
[
"Peginterferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Peginterferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sul... | Peginterferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Peginterferon beta-1a may cause a moderate interaction that could exacerbate diseases whe... |
DB00983 | DB01021 | 480 | 674 | [
"DDInter776",
"DDInter1861"
] | Formoterol | Trichlormethiazide | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830) | Moderate | 1 | [
[
[
480,
24,
674
]
],
[
[
480,
63,
1014
],
[
1014,
40,
674
]
],
[
[
480,
24,
178
],
[
178,
1,
674
]
],
[
[
480,
63,
455
],
[
455,
24... | [
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trichlormethiazide"
]
],
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzthiazide"
]... | Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Benzthiazide and Benzthiazide (Compound) resembles Trichlormethiazide (Compound)
Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Polythiazide and Polythiazide (Compound) resembles Trichl... |
DB00603 | DB00673 | 303 | 723 | [
"DDInter1137",
"DDInter112"
] | Medroxyprogesterone acetate | Aprepitant | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Moderate | 1 | [
[
[
303,
24,
723
]
],
[
[
303,
24,
875
],
[
875,
40,
723
]
],
[
[
303,
6,
8374
],
[
8374,
45,
723
]
],
[
[
303,
10,
11579
],
[
11579,
... | [
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases when taken with Fosaprepitant and Fosaprepitant (Compound) resembles Aprepitant (Compound)
Medroxyprogesterone acetate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Aprepitant (Compound)
Medroxyprogesterone acetat... |
DB00549 | DB00900 | 522 | 45 | [
"DDInter1955",
"DDInter544"
] | Zafirlukast | Didanosine | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-termi... | Moderate | 1 | [
[
[
522,
24,
45
]
],
[
[
522,
21,
28681
],
[
28681,
60,
45
]
],
[
[
522,
24,
36
],
[
36,
63,
45
]
],
[
[
522,
63,
491
],
[
491,
24,
... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Didanosine"
]
],
[
[
"Zafirlukast",
"{u} (Compound) causes {v} (Side Effect)",
"Hypersensitivity"
],
[
"Hypersensitivity",
"{u} (Side... | Zafirlukast (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Didanosine (Compound)
Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Eribulin and Eribulin may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00624 | DB09228 | 1,561 | 687 | [
"DDInter1775",
"DDInter437"
] | Testosterone | Conestat alfa | Testosterone is a steroid sex hormone indicated to treat primary hypogonadism and hypogonadotropic hypogonadism.[L8983,L8935,L8938,L8986,L8989,L8992,L8995] Testosterone antagonizes the androgen receptor to induce gene expression that causes the growth and development of masculine sex organs and secondary sexual charact... | C1 Esterase Inhibitor (Recombinant) is a recombinant analogue of endogenous complement component-1 esterase inhibitor (rhC1INH), purified from the milk of transgenic rabbits. The primary function of endogenous C1INH is to regulate the activation of the complement and contact system pathways. It does this through inhibi... | Moderate | 1 | [
[
[
1561,
24,
687
]
],
[
[
1561,
1,
1026
],
[
1026,
24,
687
]
],
[
[
1561,
40,
1581
],
[
1581,
24,
687
]
],
[
[
1561,
25,
350
],
[
350,
... | [
[
[
"Testosterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Conestat alfa"
]
],
[
[
"Testosterone",
"{u} (Compound) resembles {v} (Compound)",
"Oxandrolone"
],
[
"Oxandrolone",
"{u} may cause ... | Testosterone (Compound) resembles Oxandrolone (Compound) and Oxandrolone may cause a moderate interaction that could exacerbate diseases when taken with Conestat alfa
Testosterone (Compound) resembles Testolactone (Compound) and Testolactone may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB01114 | DB04908 | 272 | 1,671 | [
"DDInter362",
"DDInter741"
] | Chlorpheniramine | Flibanserin | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder... | Moderate | 1 | [
[
[
272,
24,
1671
]
],
[
[
272,
24,
741
],
[
741,
63,
1671
]
],
[
[
272,
24,
830
],
[
830,
24,
1671
]
],
[
[
272,
74,
1594
],
[
1594,
... | [
[
[
"Chlorpheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flibanserin"
]
],
[
[
"Chlorpheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
... | Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant and Rolapitant may cause a moderate interaction that could exacerbate diseases when taken with Flibanserin
Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Pheninda... |
DB00514 | DB09034 | 506 | 1,313 | [
"DDInter527",
"DDInter1733"
] | Dextromethorphan | Suvorexant | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Suvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing wakefulness and arousal. It has been approved for the treatment of insomnia. | Moderate | 1 | [
[
[
506,
24,
1313
]
],
[
[
506,
24,
649
],
[
649,
24,
1313
]
],
[
[
506,
63,
530
],
[
530,
24,
1313
]
],
[
[
506,
24,
1609
],
[
1609,
... | [
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Suvorexant"
]
],
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
... | Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Suvorexant
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Dronabino... |
DB01254 | DB04932 | 1,213 | 1,564 | [
"DDInter484",
"DDInter491"
] | Dasatinib | Defibrotide | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Da... | Major | 2 | [
[
[
1213,
25,
1564
]
],
[
[
1213,
23,
539
],
[
539,
62,
1564
]
],
[
[
1213,
64,
914
],
[
914,
24,
1564
]
],
[
[
1213,
63,
1039
],
[
1039,
... | [
[
[
"Dasatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Defibrotide"
]
],
[
[
"Dasatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsicum",
... | Dasatinib may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Defibrotide
Dasatinib may lead to a major life threatening interaction when taken with Diflunisal and Diflunisal may cause a moderat... |
DB00480 | DB09061 | 1,668 | 1,627 | [
"DDInter1035",
"DDInter284"
] | Lenalidomide | Cannabidiol | Lenalidomide (previously referred to as CC-5013) is an immunomodulatory drug with potent antineoplastic, anti-angiogenic, and anti-inflammatory properties. It is a 4-amino-glutamyl analogue of [thalidomide] and like thalidomide, lenalidomide exists as a racemic mixture of the active S(-) and R(+) forms. However, lenali... | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
1668,
24,
1627
]
],
[
[
1668,
24,
384
],
[
384,
23,
1627
]
],
[
[
1668,
63,
597
],
[
597,
23,
1627
]
],
[
[
1668,
25,
888
],
[
888,
... | [
[
[
"Lenalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Lenalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
... | Lenalidomide may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a minor interaction that can limit clinical effects when taken with Cannabidiol
Lenalidomide may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol an... |
DB01244 | DB09268 | 762 | 1,662 | [
"DDInter192",
"DDInter1464"
] | Bepridil | Picosulfuric acid | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Major | 2 | [
[
[
762,
25,
1662
]
],
[
[
762,
25,
484
],
[
484,
63,
1662
]
],
[
[
762,
25,
1618
],
[
1618,
24,
1662
]
],
[
[
762,
64,
1555
],
[
1555,
... | [
[
[
"Bepridil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Bepridil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Entrectinib"
],
[
"Entrectinib",
"... | Bepridil may lead to a major life threatening interaction when taken with Entrectinib and Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Bepridil may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib may cause a mode... |
DB01415 | DB09268 | 1,521 | 1,662 | [
"DDInter331",
"DDInter1464"
] | Ceftibuten | Picosulfuric acid | Ceftibuten is a third-generation cephalosporin antibiotic that is orally-administered. It is typically used to treat acute bacterial exacerbations of chronic bronchitis (ABECB), acute bacterial otitis media, pharyngitis, and tonsilitis. | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
1521,
24,
1662
]
],
[
[
1521,
63,
597
],
[
597,
24,
1662
]
],
[
[
1521,
1,
1403
],
[
1403,
24,
1662
]
],
[
[
1521,
40,
778
],
[
778,
... | [
[
[
"Ceftibuten",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Ceftibuten",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphenicol"
... | Ceftibuten may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Ceftibuten (Compound) resembles Cefepime (Compound) and Cefepime may cause a moderate interacti... |
DB00290 | DB01165 | 329 | 1,539 | [
"DDInter219",
"DDInter1325"
] | Bleomycin | Ofloxacin | A complex of related glycopeptide antibiotics from <i>Streptomyces verticillus</i> consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin. | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Minor | 0 | [
[
[
329,
23,
1539
]
],
[
[
329,
23,
1467
],
[
1467,
1,
1539
]
],
[
[
329,
62,
1176
],
[
1176,
1,
1539
]
],
[
[
329,
23,
945
],
[
945,
... | [
[
[
"Bleomycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ofloxacin"
]
],
[
[
"Bleomycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Enoxacin"
],
[
"Enox... | Bleomycin may cause a minor interaction that can limit clinical effects when taken with Enoxacin and Enoxacin (Compound) resembles Ofloxacin (Compound)
Bleomycin may cause a minor interaction that can limit clinical effects when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Ofloxacin (Compound)
Bleomyci... |
DB00446 | DB04835 | 597 | 1,655 | [
"DDInter351",
"DDInter1125"
] | Chloramphenicol | Maraviroc | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Maraviroc (brand-named Selzentry, or Celsentri outside the U.S.) is a chemokine receptor antagonist drug developed by the drug company Pfizer that is designed to act against HIV by interfering with the interaction between HIV and CCR5. It was originally labelled as UK-427857 during development but was assigned the Mara... | Moderate | 1 | [
[
[
597,
24,
1655
]
],
[
[
597,
6,
8374
],
[
8374,
45,
1655
]
],
[
[
597,
21,
28792
],
[
28792,
60,
1655
]
],
[
[
597,
24,
372
],
[
372,
... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Maraviroc"
]
],
[
[
"Chloramphenicol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Co... | Chloramphenicol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Maraviroc (Compound)
Chloramphenicol (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Maraviroc (Compound)
Chloramphenicol may cause a moderate interaction that could exacerbate... |
DB00348 | DB11979 | 254 | 1,320 | [
"DDInter1300",
"DDInter625"
] | Nitisinone | Elagolix | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
254,
24,
1320
]
],
[
[
254,
24,
1297
],
[
1297,
24,
1320
]
],
[
[
254,
24,
484
],
[
484,
63,
1320
]
],
[
[
254,
63,
288
],
[
288,
... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
],
[
... | Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Osilodrostat and Osilodrostat may cause a moderate interaction that could exacerbate diseases when taken with Elagolix
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and Ent... |
DB01165 | DB01390 | 1,539 | 1,117 | [
"DDInter1325",
"DDInter1683"
] | Ofloxacin | Sodium bicarbonate | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions. | Moderate | 1 | [
[
[
1539,
24,
1117
]
],
[
[
1539,
21,
29093
],
[
29093,
60,
1117
]
],
[
[
1539,
25,
1220
],
[
1220,
23,
1117
]
],
[
[
1539,
64,
1573
],
[
... | [
[
[
"Ofloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium bicarbonate"
]
],
[
[
"Ofloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Fatigue"
],
[
"Fatigue",
"{u} (Side Effect) is ca... | Ofloxacin (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Sodium bicarbonate (Compound)
Ofloxacin may lead to a major life threatening interaction when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Sodium bicarbona... |
DB01069 | DB01148 | 401 | 1,128 | [
"DDInter1533",
"DDInter738"
] | Promethazine | Flavoxate | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | A drug that has been used in various urinary syndromes and as an antispasmodic. Its therapeutic usefulness and its mechanism of action are not clear. It may have local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a muscarinic antagonist. [PubChem] | Moderate | 1 | [
[
[
401,
24,
1128
]
],
[
[
401,
6,
7992
],
[
7992,
45,
1128
]
],
[
[
401,
21,
28769
],
[
28769,
60,
1128
]
],
[
[
401,
24,
537
],
[
537,
... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flavoxate"
]
],
[
[
"Promethazine",
"{u} (Compound) binds {v} (Gene)",
"CHRM1"
],
[
"CHRM1",
"{u} (Gene) is bound by {v} (Compound)"... | Promethazine (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Flavoxate (Compound)
Promethazine (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Flavoxate (Compound)
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Cyc... |
DB00907 | DB11124 | 290 | 209 | [
"DDInter427",
"DDInter1560"
] | Cocaine (topical) | Racepinephrine | Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts. | Racepinephrine is a racemic mixture consisting of d- and l- enantiomers. Epinephrine is a non-selective α- and β-adrenergic receptor agonist. It is a bronchodilator used in the temporary relief of mild symptoms of intermittent asthma including wheezing, tightness of chest and shortness of breath. It is an active ingred... | Major | 2 | [
[
[
290,
25,
209
]
],
[
[
290,
25,
688
],
[
688,
24,
209
]
],
[
[
290,
64,
1674
],
[
1674,
24,
209
]
],
[
[
290,
25,
688
],
[
688,
2... | [
[
[
"Cocaine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Racepinephrine"
]
],
[
[
"Cocaine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Salbutamol"
],
[
"Salbutamol",
"{u} may... | Cocaine may lead to a major life threatening interaction when taken with Racepinephrine
Cocaine may lead to a major life threatening interaction when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Racepinephrine
Cocaine may lead to a major life threa... |
DB01045 | DB11581 | 463 | 1,456 | [
"DDInter1590",
"DDInter1926"
] | Rifampicin | Venetoclax | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Major | 2 | [
[
[
463,
25,
1456
]
],
[
[
463,
25,
1135
],
[
1135,
23,
1456
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],
[
[
463,
25,
1476
],
[
1476,
63,
1456
]
],
[
[
463,
63,
1413
],
[
1413,
... | [
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Venetoclax"
]
],
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} may... | Rifampicin may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Venetoclax
Rifampicin may lead to a major life threatening interaction when taken with Brigatinib and Brigatinib may cause a moderate interact... |
DB00284 | DB00388 | 1,647 | 1,636 | [
"DDInter11",
"DDInter1453"
] | Acarbose | Phenylephrine | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939. | Moderate | 1 | [
[
[
1647,
24,
1636
]
],
[
[
1647,
24,
874
],
[
874,
40,
1636
]
],
[
[
1647,
24,
1148
],
[
1148,
63,
1636
]
],
[
[
1647,
21,
28734
],
[
287... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylephrine"
]
],
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
],
[
... | Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine (Compound) resembles Phenylephrine (Compound)
Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that ... |
DB01132 | DB11921 | 1,130 | 1,019 | [
"DDInter1472",
"DDInter492"
] | Pioglitazone | Deflazacort | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
1130,
24,
1019
]
],
[
[
1130,
63,
1072
],
[
1072,
23,
1019
]
],
[
[
1130,
24,
192
],
[
192,
24,
1019
]
],
[
[
1130,
63,
359
],
[
359,
... | [
[
[
"Pioglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Pioglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoniazid"
],
... | Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Isoniazid and Isoniazid may cause a minor interaction that can limit clinical effects when taken with Deflazacort
Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Esterified estrogens... |
DB00564 | DB06674 | 1,236 | 908 | [
"DDInter293",
"DDInter837"
] | Carbamazepine | Golimumab | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Moderate | 1 | [
[
[
1236,
24,
908
]
],
[
[
1236,
24,
1487
],
[
1487,
24,
908
]
],
[
[
1236,
40,
362
],
[
362,
24,
908
]
],
[
[
1236,
62,
608
],
[
608,
... | [
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Golimumab"
]
],
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
... | Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Hydroxychloroquine and Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Golimumab
Carbamazepine (Compound) resembles Phenytoin (Compound) and Phenytoin may cause a moderate int... |
DB00193 | DB00981 | 534 | 1,528 | [
"DDInter1841",
"DDInter1462"
] | Tramadol | Physostigmine | Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatmen... | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | Major | 2 | [
[
[
534,
25,
1528
]
],
[
[
534,
21,
28751
],
[
28751,
60,
1528
]
],
[
[
534,
24,
1511
],
[
1511,
63,
1528
]
],
[
[
534,
24,
543
],
[
543,
... | [
[
[
"Tramadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Physostigmine"
]
],
[
[
"Tramadol",
"{u} (Compound) causes {v} (Side Effect)",
"Convulsion"
],
[
"Convulsion",
"{u} (Side Effect) is caused by {v} (Com... | Tramadol (Compound) causes Convulsion (Side Effect) and Convulsion (Side Effect) is caused by Physostigmine (Compound)
Tramadol may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Phys... |
DB00030 | DB14509 | 1,685 | 1,399 | [
"DDInter934",
"DDInter1081"
] | Insulin human | Lithium carbonate | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Moderate | 1 | [
[
[
1685,
24,
1399
]
],
[
[
1685,
24,
964
],
[
964,
23,
1399
]
],
[
[
1685,
24,
1385
],
[
1385,
24,
1399
]
],
[
[
1685,
23,
274
],
[
274,
... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxycycline"
... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Doxycycline and Doxycycline may cause a minor interaction that can limit clinical effects when taken with Lithium carbonate
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Semaglut... |
DB00794 | DB11130 | 759 | 407 | [
"DDInter1521",
"DDInter1344"
] | Primidone | Opium | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
759,
24,
407
]
],
[
[
759,
63,
662
],
[
662,
24,
407
]
],
[
[
759,
25,
976
],
[
976,
24,
407
]
],
[
[
759,
24,
104
],
[
104,
24,... | [
[
[
"Primidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Primidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
[
... | Primidone may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Primidone may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may cause... |
DB00363 | DB06663 | 695 | 1,154 | [
"DDInter419",
"DDInter1398"
] | Clozapine | Pasireotide | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
695,
25,
1154
]
],
[
[
695,
23,
112
],
[
112,
23,
1154
]
],
[
[
695,
24,
1385
],
[
1385,
63,
1154
]
],
[
[
695,
25,
663
],
[
663,
... | [
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Clozapine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidaz... | Clozapine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pasireotide
Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide and Sema... |
DB00791 | DB08895 | 132 | 976 | [
"DDInter1902",
"DDInter1825"
] | Uracil mustard | Tofacitinib | Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage. | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
132,
25,
976
]
],
[
[
132,
63,
1461
],
[
1461,
23,
976
]
],
[
[
132,
24,
496
],
[
496,
63,
976
]
],
[
[
132,
24,
1430
],
[
1430,
... | [
[
[
"Uracil mustard",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Uracil mustard",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vi... | Uracil mustard may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Tofacitinib
Uracil mustard may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vacc... |
DB00104 | DB01118 | 966 | 33 | [
"DDInter1323",
"DDInter76"
] | Octreotide | Amiodarone | Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may... | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Moderate | 1 | [
[
[
966,
24,
33
]
],
[
[
966,
24,
540
],
[
540,
1,
33
]
],
[
[
966,
21,
28779
],
[
28779,
60,
33
]
],
[
[
966,
23,
466
],
[
466,
62,... | [
[
[
"Octreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiodarone"
]
],
[
[
"Octreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronedarone"
],
[
... | Octreotide may cause a moderate interaction that could exacerbate diseases when taken with Dronedarone and Dronedarone (Compound) resembles Amiodarone (Compound)
Octreotide (Compound) causes Dry mouth (Side Effect) and Dry mouth (Side Effect) is caused by Amiodarone (Compound)
Octreotide may cause a minor interaction t... |
DB00679 | DB01087 | 684 | 1,520 | [
"DDInter1796",
"DDInter1520"
] | Thioridazine | Primaquine | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Major | 2 | [
[
[
684,
25,
1520
]
],
[
[
684,
25,
1487
],
[
1487,
64,
1520
]
],
[
[
684,
6,
12523
],
[
12523,
45,
1520
]
],
[
[
684,
21,
28722
],
[
2872... | [
[
[
"Thioridazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Primaquine"
]
],
[
[
"Thioridazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
],
[
"Hydroxychloro... | Thioridazine may lead to a major life threatening interaction when taken with Hydroxychloroquine and Hydroxychloroquine may lead to a major life threatening interaction when taken with Primaquine
Thioridazine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Primaquine (Compound)
Thioridazine (Compound) caus... |
DB00196 | DB00543 | 600 | 87 | [
"DDInter743",
"DDInter82"
] | Fluconazole | Amoxapine | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | Moderate | 1 | [
[
[
600,
24,
87
]
],
[
[
600,
24,
623
],
[
623,
40,
87
]
],
[
[
600,
25,
695
],
[
695,
40,
87
]
],
[
[
600,
24,
867
],
[
867,
1,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amoxapine"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quetiapine"
],
[
... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Quetiapine and Quetiapine (Compound) resembles Amoxapine (Compound)
Fluconazole may lead to a major life threatening interaction when taken with Clozapine and Clozapine (Compound) resembles Amoxapine (Compound)
Fluconazole may c... |
DB00468 | DB00850 | 1,424 | 1,630 | [
"DDInter1557",
"DDInter1432"
] | Quinine | Perphenazine | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Moderate | 1 | [
[
[
1424,
24,
1630
]
],
[
[
1424,
24,
252
],
[
252,
40,
1630
]
],
[
[
1424,
63,
508
],
[
508,
40,
1630
]
],
[
[
1424,
25,
684
],
[
684,
... | [
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perphenazine"
]
],
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyzine"
],
[
... | Quinine may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyzine and Hydroxyzine (Compound) resembles Perphenazine (Compound)
Quinine may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine (Compound) resembles Perphenazine (Compound)
Qu... |
DB01100 | DB09065 | 1,568 | 760 | [
"DDInter1470",
"DDInter424"
] | Pimozide | Cobicistat | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Major | 2 | [
[
[
1568,
25,
760
]
],
[
[
1568,
25,
1374
],
[
1374,
23,
760
]
],
[
[
1568,
64,
723
],
[
723,
24,
760
]
],
[
[
1568,
25,
868
],
[
868,
... | [
[
[
"Pimozide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobicistat"
]
],
[
[
"Pimozide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Abiraterone"
],
[
"Abiraterone",
"{u} may... | Pimozide may lead to a major life threatening interaction when taken with Abiraterone and Abiraterone may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Pimozide may lead to a major life threatening interaction when taken with Aprepitant and Aprepitant may cause a moderate interact... |
DB09054 | DB11730 | 384 | 351 | [
"DDInter905",
"DDInter1588"
] | Idelalisib | Ribociclib | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
384,
25,
351
]
],
[
[
384,
62,
271
],
[
271,
23,
351
]
],
[
[
384,
24,
466
],
[
466,
62,
351
]
],
[
[
384,
63,
1247
],
[
1247,
2... | [
[
[
"Idelalisib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Idelalisib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mirabegron"
],
[
"Mirabegron",... | Idelalisib may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Daroluta... |
DB00041 | DB01073 | 1,648 | 1,488 | [
"DDInter38",
"DDInter745"
] | Aldesleukin | Fludarabine | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Moderate | 1 | [
[
[
1648,
24,
1488
]
],
[
[
1648,
24,
372
],
[
372,
1,
1488
]
],
[
[
1648,
23,
839
],
[
839,
23,
1488
]
],
[
[
1648,
23,
1539
],
[
1539,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
],
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine (Compound) resembles Fludarabine (Compound)
Aldesleukin may cause a minor interaction that can limit clinical effects when taken with Grepafloxacin and Grepafloxacin may cause a minor interaction that... |
DB00860 | DB08822 | 891 | 911 | [
"DDInter1513",
"DDInter156"
] | Prednisolone | Azilsartan medoxomil | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Azilsartan medoxomil is a prodrug that is broken down to azilsartan, which belongs in the angiotensin-receptor blocking (ARB) drug class. It is a selective AT1 subtype angiotensin II receptor antagonist. Azilsartan medoxomil is a relatively recently-developed antihypertensive drug that was first approved by the FDA in ... | Moderate | 1 | [
[
[
891,
24,
911
]
],
[
[
891,
63,
217
],
[
217,
1,
911
]
],
[
[
891,
21,
29081
],
[
29081,
60,
911
]
],
[
[
891,
24,
1450
],
[
1450,
... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azilsartan medoxomil"
]
],
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olmesartan"
... | Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Olmesartan and Olmesartan (Compound) resembles Azilsartan medoxomil (Compound)
Prednisolone (Compound) causes Angioedema (Side Effect) and Angioedema (Side Effect) is caused by Azilsartan medoxomil (Compound)
Prednisolone may c... |
DB00741 | DB11943 | 167 | 255 | [
"DDInter885",
"DDInter495"
] | Hydrocortisone | Delafloxacin | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in t... | Major | 2 | [
[
[
167,
25,
255
]
],
[
[
167,
63,
1648
],
[
1648,
23,
255
]
],
[
[
167,
23,
1283
],
[
1283,
24,
255
]
],
[
[
167,
63,
1512
],
[
1512,
... | [
[
[
"Hydrocortisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Delafloxacin"
]
],
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
],
[
... | Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a minor interaction that can limit clinical effects when taken with Delafloxacin
Hydrocortisone may cause a minor interaction that can limit clinical effects when taken with Magnesium oxi... |
DB06212 | DB09054 | 165 | 384 | [
"DDInter1833",
"DDInter905"
] | Tolvaptan | Idelalisib | Tolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009. | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Major | 2 | [
[
[
165,
25,
384
]
],
[
[
165,
24,
1618
],
[
1618,
24,
384
]
],
[
[
165,
63,
305
],
[
305,
24,
384
]
],
[
[
165,
23,
466
],
[
466,
6... | [
[
[
"Tolvaptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idelalisib"
]
],
[
[
"Tolvaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabozantinib"
],
[
"Cabozantin... | Tolvaptan may cause a moderate interaction that could exacerbate diseases when taken with Cabozantinib and Cabozantinib may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Tolvaptan may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escher... |
DB00261 | DB01225 | 702 | 500 | [
"DDInter93",
"DDInter645"
] | Anagrelide | Enoxaparin | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies. Enoxaparin markedly reduces the inc... | Major | 2 | [
[
[
702,
25,
500
]
],
[
[
702,
21,
29173
],
[
29173,
60,
500
]
],
[
[
702,
23,
297
],
[
297,
62,
500
]
],
[
[
702,
64,
1230
],
[
1230,
... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enoxaparin"
]
],
[
[
"Anagrelide",
"{u} (Compound) causes {v} (Side Effect)",
"Oedema peripheral"
],
[
"Oedema peripheral",
"{u} (Side Effect) is cau... | Anagrelide (Compound) causes Oedema peripheral (Side Effect) and Oedema peripheral (Side Effect) is caused by Enoxaparin (Compound)
Anagrelide may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Enoxa... |
DB01059 | DB11827 | 956 | 433 | [
"DDInter1313",
"DDInter669"
] | Norfloxacin | Ertugliflozin | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
956,
24,
433
]
],
[
[
956,
25,
959
],
[
959,
24,
433
]
],
[
[
956,
63,
521
],
[
521,
24,
433
]
],
[
[
956,
64,
251
],
[
251,
24,... | [
[
[
"Norfloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Norfloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glipizide"
],
[
"Glipiz... | Norfloxacin may lead to a major life threatening interaction when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Norfloxacin may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin may cause... |
DB00342 | DB01254 | 1,181 | 1,213 | [
"DDInter1770",
"DDInter484"
] | Terfenadine | Dasatinib | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
1181,
24,
1213
]
],
[
[
1181,
23,
1247
],
[
1247,
23,
1213
]
],
[
[
1181,
24,
479
],
[
479,
23,
1213
]
],
[
[
1181,
24,
1133
],
[
1133... | [
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Terfenadine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Terfenadine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Dasatinib
Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Donepezil an... |
DB00218 | DB00653 | 1,176 | 544 | [
"DDInter1247",
"DDInter1120"
] | Moxifloxacin | Magnesium sulfate | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions... | Moderate | 1 | [
[
[
1176,
24,
544
]
],
[
[
1176,
21,
28766
],
[
28766,
60,
544
]
],
[
[
1176,
24,
1473
],
[
1473,
63,
544
]
],
[
[
1176,
25,
175
],
[
175,... | [
[
[
"Moxifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium sulfate"
]
],
[
[
"Moxifloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Hypotension"
],
[
"Hypotension",
"{u} (Side ... | Moxifloxacin (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Magnesium sulfate (Compound)
Moxifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Magnesium gluconate and Magnesium gluconate may cause a moderate interaction that could exacerbate... |
DB00472 | DB11095 | 758 | 235 | [
"DDInter758",
"DDInter505"
] | Fluoxetine | Desirudin | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three dis... | Moderate | 1 | [
[
[
758,
24,
235
]
],
[
[
758,
24,
1151
],
[
1151,
24,
235
]
],
[
[
758,
1,
109
],
[
109,
24,
235
]
],
[
[
758,
25,
121
],
[
121,
24... | [
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desirudin"
]
],
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
],
[
... | Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Sunitinib and Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Desirudin
Fluoxetine (Compound) resembles Duloxetine (Compound) and Duloxetine may cause a moderate interaction that could ex... |
DB00307 | DB00889 | 1,101 | 1,133 | [
"DDInter202",
"DDInter840"
] | Bexarotene | Granisetron | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Moderate | 1 | [
[
[
1101,
24,
1133
]
],
[
[
1101,
6,
8374
],
[
8374,
45,
1133
]
],
[
[
1101,
21,
29282
],
[
29282,
60,
1133
]
],
[
[
1101,
23,
697
],
[
69... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Granisetron"
]
],
[
[
"Bexarotene",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Bexarotene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Granisetron (Compound)
Bexarotene (Compound) causes Arrhythmia (Side Effect) and Arrhythmia (Side Effect) is caused by Granisetron (Compound)
Bexarotene may cause a minor interaction that can limit clinical effects when taken with Phenobarbital and... |
DB00242 | DB00717 | 1,064 | 1,197 | [
"DDInter392",
"DDInter1312"
] | Cladribine | Norethisterone | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins. It is further classified as a second-generation progestin, along with [levonorgestrel] and its derivatives, and is the active form of several other progestins including [no... | Moderate | 1 | [
[
[
1064,
24,
1197
]
],
[
[
1064,
25,
167
],
[
167,
1,
1197
]
],
[
[
1064,
24,
566
],
[
566,
40,
1197
]
],
[
[
1064,
7,
9187
],
[
9187,
... | [
[
[
"Cladribine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norethisterone"
]
],
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydrocortisone"
],
[
"Hy... | Cladribine may lead to a major life threatening interaction when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Norethisterone (Compound)
Cladribine may cause a moderate interaction that could exacerbate diseases when taken with Levonorgestrel and Levonorgestrel (Compound) resembles Norethisterone (C... |
DB00196 | DB06717 | 600 | 875 | [
"DDInter743",
"DDInter778"
] | Fluconazole | Fosaprepitant | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment. | Moderate | 1 | [
[
[
600,
24,
875
]
],
[
[
600,
24,
723
],
[
723,
1,
875
]
],
[
[
600,
21,
29340
],
[
29340,
60,
875
]
],
[
[
600,
23,
222
],
[
222,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosaprepitant"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant (Compound) resembles Fosaprepitant (Compound)
Fluconazole (Compound) causes Stevens-Johnson syndrome (Side Effect) and Stevens-Johnson syndrome (Side Effect) is caused by Fosaprepitant (Compound)
Flucon... |
DB00215 | DB01128 | 1,230 | 918 | [
"DDInter388",
"DDInter204"
] | Citalopram | Bicalutamide | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Major | 2 | [
[
[
1230,
25,
918
]
],
[
[
1230,
25,
129
],
[
129,
40,
918
]
],
[
[
1230,
6,
8374
],
[
8374,
45,
918
]
],
[
[
1230,
21,
29666
],
[
29666,
... | [
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bicalutamide"
]
],
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
],
[
"Enzalutamide",
... | Citalopram may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide (Compound) resembles Bicalutamide (Compound)
Citalopram (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bicalutamide (Compound)
Citalopram (Compound) causes Melaena (Side Effect) and Melaena (Side Effe... |
DB00056 | DB00092 | 816 | 58 | [
"DDInter814",
"DDInter40"
] | Gemtuzumab ozogamicin | Alefacept | Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from fermentation of Micromonospora echinospora ssp. calichensis. Gemtuzumab ozogamicin has approximately 50% of the antibody loaded with 4-6 moles calicheami... | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Moderate | 1 | [
[
[
816,
24,
58
]
],
[
[
816,
24,
384
],
[
384,
63,
58
]
],
[
[
816,
24,
599
],
[
599,
24,
58
]
],
[
[
816,
63,
305
],
[
305,
24,
... | [
[
[
"Gemtuzumab ozogamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alefacept"
]
],
[
[
"Gemtuzumab ozogamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelal... | Gemtuzumab ozogamicin may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Alefacept
Gemtuzumab ozogamicin may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00902 | DB01175 | 104 | 318 | [
"DDInter1168",
"DDInter672"
] | Methdilazine | Escitalopram | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Moderate | 1 | [
[
[
104,
24,
318
]
],
[
[
104,
63,
1230
],
[
1230,
1,
318
]
],
[
[
104,
6,
10104
],
[
10104,
45,
318
]
],
[
[
104,
63,
1419
],
[
1419,
... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Escitalopram"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Citalopram"
],
... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Citalopram and Citalopram (Compound) resembles Escitalopram (Compound)
Methdilazine (Compound) binds HRH1 (Gene) and HRH1 (Gene) is bound by Escitalopram (Compound)
Methdilazine may cause a moderate interaction that could exace... |
DB06589 | DB13139 | 1,250 | 1,032 | [
"DDInter1400",
"DDInter1063"
] | Pazopanib | Levosalbutamol | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). [Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective ... | Moderate | 1 | [
[
[
1250,
24,
1032
]
],
[
[
1250,
63,
1220
],
[
1220,
23,
1032
]
],
[
[
1250,
25,
1618
],
[
1618,
24,
1032
]
],
[
[
1250,
24,
124
],
[
124... | [
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levosalbutamol"
]
],
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
... | Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Levosalbutamol
Pazopanib may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib ... |
DB00776 | DB09278 | 1,335 | 852 | [
"DDInter1360",
"DDInter24"
] | Oxcarbazepine | Activated charcoal | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Activated charcoal, or activated carbon, is an amorphous form of carbon prepared from incomplete combustion of carbonaceous organic matter. It is activated by an oxidizing gas flow at high temperature passed over its surface to make a fine network of pores, producing a material with large surface area and high affinity... | Moderate | 1 | [
[
[
1335,
24,
852
]
],
[
[
1335,
40,
21
],
[
21,
24,
852
]
],
[
[
1335,
24,
1411
],
[
1411,
24,
852
]
],
[
[
1335,
63,
999
],
[
999,
... | [
[
[
"Oxcarbazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Activated charcoal"
]
],
[
[
"Oxcarbazepine",
"{u} (Compound) resembles {v} (Compound)",
"Amitriptyline"
],
[
"Amitriptyline",
"{u}... | Oxcarbazepine (Compound) resembles Amitriptyline (Compound) and Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Activated charcoal
Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate ... |
DB00808 | DB09472 | 1,605 | 1,383 | [
"DDInter916",
"DDInter1693"
] | Indapamide | Sodium sulfate | The most significant modifiable risk factor for cardiovascular disease and the most prominent contributor to all-cause mortality is hypertension. Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts an estimated 25% of adults globally. Treatment for hypertension should include a n... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
1605,
24,
1383
]
],
[
[
1605,
24,
104
],
[
104,
24,
1383
]
],
[
[
1605,
63,
475
],
[
475,
24,
1383
]
],
[
[
1605,
24,
407
],
[
407,
... | [
[
[
"Indapamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Indapamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
... | Indapamide may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Indapamide may cause a moderate interaction that could exacerbate diseases when taken with Morphine and ... |
DB01611 | DB11110 | 1,487 | 603 | [
"DDInter893",
"DDInter1115"
] | Hydroxychloroquine | Magnesium citrate | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
1487,
24,
603
]
],
[
[
1487,
64,
57
],
[
57,
24,
603
]
],
[
[
1487,
24,
1616
],
[
1616,
24,
603
]
],
[
[
1487,
25,
484
],
[
484,
... | [
[
[
"Hydroxychloroquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Hydroxychloroquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
... | Hydroxychloroquine may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with H... |
DB00598 | DB09038 | 1,523 | 1,450 | [
"DDInter1013",
"DDInter636"
] | Labetalol | Empagliflozin | Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture. Labetalol is formulated as an injection or tablets to treat hypertension.[L7727,L7730] Labetalol was granted FDA approval on 1 August 1984. | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
1523,
24,
1450
]
],
[
[
1523,
25,
659
],
[
659,
63,
1450
]
],
[
[
1523,
63,
1061
],
[
1061,
24,
1450
]
],
[
[
1523,
24,
1486
],
[
1486... | [
[
[
"Labetalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Labetalol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vilanterol"
],
[
"Vilantero... | Labetalol may lead to a major life threatening interaction when taken with Vilanterol and Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Labetalol may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may c... |
DB00277 | DB13179 | 1,031 | 68 | [
"DDInter1791",
"DDInter1882"
] | Theophylline | Troleandomycin | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | A macrolide antibiotic that is similar to erythromycin. | Moderate | 1 | [
[
[
1031,
24,
68
]
],
[
[
1031,
24,
1662
],
[
1662,
24,
68
]
],
[
[
1031,
63,
912
],
[
912,
24,
68
]
],
[
[
1031,
23,
1096
],
[
1096,
... | [
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troleandomycin"
]
],
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
... | Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid and Picosulfuric acid may cause a moderate interaction that could exacerbate diseases when taken with Troleandomycin
Theophylline may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00398 | DB00812 | 79 | 998 | [
"DDInter1702",
"DDInter1451"
] | Sorafenib | Phenylbutazone | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Moderate | 1 | [
[
[
79,
24,
998
]
],
[
[
79,
64,
576
],
[
576,
1,
998
]
],
[
[
79,
24,
804
],
[
804,
40,
998
]
],
[
[
79,
24,
307
],
[
307,
1,
... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylbutazone"
]
],
[
[
"Sorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methadone"
],
[
"Methadone... | Sorafenib may lead to a major life threatening interaction when taken with Methadone and Methadone (Compound) resembles Phenylbutazone (Compound)
Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Sulfinpyrazone and Sulfinpyrazone (Compound) resembles Phenylbutazone (Compound)
Sor... |
DB01157 | DB14409 | 304 | 1,129 | [
"DDInter1875",
"DDInter867"
] | Trimetrexate | Human adenovirus e serotype 4 strain cl-68578 antigen | A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against pneumocystis pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect. | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
304,
24,
1129
]
],
[
[
304,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
304,
24,
1683
],
[
1683,
24,
1129
]
],
[
[
304,
63,
372
],
[
372,
... | [
[
[
"Trimetrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Trimetrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Trimetrexate may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Trimetrexate may cause a moderate interaction that could exacerbate diseases when ... |
DB00277 | DB01222 | 1,031 | 617 | [
"DDInter1791",
"DDInter246"
] | Theophylline | Budesonide | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Moderate | 1 | [
[
[
1031,
24,
617
]
],
[
[
1031,
24,
251
],
[
251,
1,
617
]
],
[
[
1031,
5,
11649
],
[
11649,
44,
617
]
],
[
[
1031,
6,
8374
],
[
8374,
... | [
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Budesonide"
]
],
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betamethasone"
],
... | Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone (Compound) resembles Budesonide (Compound)
Theophylline (Compound) treats asthma (Disease) and asthma (Disease) is treated by Budesonide (Compound)
Theophylline (Compound) binds CYP3A4 (Gene) and... |
DB01097 | DB10429 | 1,377 | 200 | [
"DDInter1033",
"DDInter282"
] | Leflunomide | Candida albicans | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Moderate | 1 | [
[
[
1377,
24,
200
]
],
[
[
1377,
64,
1096
],
[
1096,
24,
200
]
],
[
[
1377,
25,
1683
],
[
1683,
24,
200
]
],
[
[
1377,
25,
1019
],
[
1019,... | [
[
[
"Leflunomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
]
],
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mycophenolic acid"
],
[
... | Leflunomide may lead to a major life threatening interaction when taken with Mycophenolic acid and Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans
Leflunomide may lead to a major life threatening interaction when taken with Ustekinumab and Ustekinumab m... |
DB00686 | DB06603 | 383 | 39 | [
"DDInter1424",
"DDInter1387"
] | Pentosan polysulfate | Panobinostat | Pentosan polysulfate is a sulfated pentosyl polysaccharide with heparin-like properties. | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Moderate | 1 | [
[
[
383,
24,
39
]
],
[
[
383,
24,
578
],
[
578,
63,
39
]
],
[
[
383,
24,
765
],
[
765,
24,
39
]
],
[
[
383,
24,
1409
],
[
1409,
64,
... | [
[
[
"Pentosan polysulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Panobinostat"
]
],
[
[
"Pentosan polysulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticag... | Pentosan polysulfate may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Panobinostat
Pentosan polysulfate may cause a moderate interaction that could exacerbate diseases when taken with... |
DB01367 | DB08880 | 1,163 | 1,510 | [
"DDInter1572",
"DDInter1771"
] | Rasagiline | Teriflunomide | Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases. | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Moderate | 1 | [
[
[
1163,
24,
1510
]
],
[
[
1163,
63,
1144
],
[
1144,
24,
1510
]
],
[
[
1163,
24,
985
],
[
985,
64,
1510
]
],
[
[
1163,
64,
593
],
[
593,
... | [
[
[
"Rasagiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Teriflunomide"
]
],
[
[
"Rasagiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
],
... | Rasagiline may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide
Rasagiline may cause a moderate interaction that could exacerbate diseases when taken with Osimertinib and ... |
DB00445 | DB12001 | 322 | 564 | [
"DDInter655",
"DDInter7"
] | Epirubicin | Abemaciclib | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Moderate | 1 | [
[
[
322,
24,
564
]
],
[
[
322,
25,
868
],
[
868,
24,
564
]
],
[
[
322,
24,
748
],
[
748,
24,
564
]
],
[
[
322,
63,
58
],
[
58,
24,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abemaciclib"
]
],
[
[
"Epirubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
],
[
"Vemurafe... | Epirubicin may lead to a major life threatening interaction when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine and Anthrax vacci... |
DB01211 | DB11799 | 609 | 627 | [
"DDInter393",
"DDInter205"
] | Clarithromycin | Bictegravir | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Bictegravir is a recently approved investigational drug that has been used in trials studying the treatment of HIV-1 and HIV-2 infection. It has been approved for HIV-1 monotherapy combined with 2 other antiretrovirals in a single tablet. | Moderate | 1 | [
[
[
609,
24,
627
]
],
[
[
609,
25,
1362
],
[
1362,
24,
627
]
],
[
[
609,
62,
600
],
[
600,
24,
627
]
],
[
[
609,
24,
466
],
[
466,
6... | [
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bictegravir"
]
],
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Olaparib"
],
[
"Ola... | Clarithromycin may lead to a major life threatening interaction when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Bictegravir
Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Fluconazole and Fluconazole may c... |
DB00685 | DB00851 | 1,299 | 611 | [
"DDInter1887",
"DDInter463"
] | Trovafloxacin | Dacarbazine | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | Minor | 0 | [
[
[
1299,
23,
611
]
],
[
[
1299,
1,
739
],
[
739,
62,
611
]
],
[
[
1299,
1,
1467
],
[
1467,
23,
611
]
],
[
[
1299,
62,
141
],
[
141,
... | [
[
[
"Trovafloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dacarbazine"
]
],
[
[
"Trovafloxacin",
"{u} (Compound) resembles {v} (Compound)",
"Lomefloxacin"
],
[
"Lomefloxacin",
"{u} may cause ... | Trovafloxacin (Compound) resembles Lomefloxacin (Compound) and Lomefloxacin may cause a minor interaction that can limit clinical effects when taken with Dacarbazine
Trovafloxacin (Compound) resembles Enoxacin (Compound) and Enoxacin may cause a minor interaction that can limit clinical effects when taken with Dacarbaz... |
DB08868 | DB11988 | 1,011 | 270 | [
"DDInter737",
"DDInter1321"
] | Fingolimod | Ocrelizumab | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Major | 2 | [
[
[
1011,
25,
270
]
],
[
[
1011,
25,
1060
],
[
1060,
63,
270
]
],
[
[
1011,
64,
134
],
[
134,
24,
270
]
],
[
[
1011,
25,
1019
],
[
1019,
... | [
[
[
"Fingolimod",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Fingolimod",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enfortumab vedotin"
],
[
"Enfortumab vedot... | Fingolimod may lead to a major life threatening interaction when taken with Enfortumab vedotin and Enfortumab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab
Fingolimod may lead to a major life threatening interaction when taken with Vinorelbine and Vinorelbine may ca... |
DB00501 | DB11986 | 752 | 484 | [
"DDInter380",
"DDInter648"
] | Cimetidine | Entrectinib | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
752,
24,
484
]
],
[
[
752,
23,
271
],
[
271,
23,
484
]
],
[
[
752,
23,
466
],
[
466,
62,
484
]
],
[
[
752,
23,
510
],
[
510,
24,... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Cimetidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mirabegron"
],
[
... | Cimetidine may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Cimetidine may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutam... |
DB01359 | DB09082 | 729 | 659 | [
"DDInter1417",
"DDInter1934"
] | Penbutolol | Vilanterol | Penbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergic receptors, since it is a sympathomimetric drug. Penbutolol also demonstrates high... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Major | 2 | [
[
[
729,
25,
659
]
],
[
[
729,
63,
1220
],
[
1220,
23,
659
]
],
[
[
729,
24,
1296
],
[
1296,
63,
659
]
],
[
[
729,
24,
1450
],
[
1450,
... | [
[
[
"Penbutolol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vilanterol"
]
],
[
[
"Penbutolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
[
"Dexamet... | Penbutolol may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Penbutolol may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec ... |
DB00470 | DB00790 | 530 | 664 | [
"DDInter601",
"DDInter1431"
] | Dronabinol | Perindopril | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible fo... | Moderate | 1 | [
[
[
530,
24,
664
]
],
[
[
530,
24,
1638
],
[
1638,
1,
664
]
],
[
[
530,
24,
954
],
[
954,
40,
664
]
],
[
[
530,
6,
4973
],
[
4973,
4... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perindopril"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trandolapril"
],
[... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril and Trandolapril (Compound) resembles Perindopril (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril (Compound) resembles Perindopril (Compou... |
DB00041 | DB01284 | 1,648 | 1,042 | [
"DDInter38",
"DDInter1782"
] | Aldesleukin | Tetracosactide | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Moderate | 1 | [
[
[
1648,
24,
1042
]
],
[
[
1648,
24,
1023
],
[
1023,
24,
1042
]
],
[
[
1648,
24,
1683
],
[
1683,
63,
1042
]
],
[
[
1648,
25,
1137
],
[
11... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentobarbital"
],... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Pentobarbital and Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Tetracosactide
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Ustekinum... |
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