drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00687 | DB01050 | 870 | 848 | [
"DDInter747",
"DDInter900"
] | Fludrocortisone | Ibuprofen | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Moderate | 1 | [
[
[
870,
24,
848
]
],
[
[
870,
21,
29404
],
[
29404,
60,
848
]
],
[
[
870,
63,
362
],
[
362,
23,
848
]
],
[
[
870,
24,
286
],
[
286,
... | [
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
]
],
[
[
"Fludrocortisone",
"{u} (Compound) causes {v} (Side Effect)",
"Cataract"
],
[
"Cataract",
"{u} (Side Effect) ... | Fludrocortisone (Compound) causes Cataract (Side Effect) and Cataract (Side Effect) is caused by Ibuprofen (Compound)
Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin may cause a minor interaction that can limit clinical effects when taken with Ibup... |
DB00334 | DB00514 | 867 | 506 | [
"DDInter1326",
"DDInter527"
] | Olanzapine | Dextromethorphan | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Moderate | 1 | [
[
[
867,
24,
506
]
],
[
[
867,
6,
8374
],
[
8374,
45,
506
]
],
[
[
867,
63,
1324
],
[
1324,
24,
506
]
],
[
[
867,
24,
13
],
[
13,
24... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextromethorphan"
]
],
[
[
"Olanzapine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compo... | Olanzapine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dextromethorphan (Compound)
Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan
Ol... |
DB00196 | DB09074 | 600 | 1,362 | [
"DDInter743",
"DDInter1327"
] | Fluconazole | Olaparib | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Major | 2 | [
[
[
600,
25,
1362
]
],
[
[
600,
24,
627
],
[
627,
63,
1362
]
],
[
[
600,
24,
896
],
[
896,
24,
1362
]
],
[
[
600,
25,
576
],
[
576,
... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Olaparib"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bictegravir"
],
[
"Bictegrav... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Bictegravir and Bictegravir may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etopo... |
DB06704 | DB14711 | 247 | 779 | [
"DDInter952",
"DDInter1680"
] | Iobenguane (I-131) | Smallpox (Vaccinia) Vaccine, Live | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | The New York City Board of Health strain of _Vaccinia_ is a viral strain used as a component of some smallpox vaccinations. ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this strain. | Major | 2 | [
[
[
247,
25,
779
]
],
[
[
247,
7,
6952
],
[
6952,
46,
77
],
[
77,
25,
779
]
],
[
[
247,
18,
7359
],
[
7359,
57,
147
],
[
147,
25,
... | [
[
[
"Iobenguane",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Smallpox (Vaccinia) Vaccine, Live"
]
],
[
[
"Iobenguane",
"{u} (Compound) upregulates {v} (Gene)",
"MCOLN1"
],
[
"MCOLN1",
"{u} (Gene) is upregulated... | Iobenguane may lead to a major life threatening interaction when taken with Smallpox (Vaccinia) Vaccine, Live
Iobenguane (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Idarubicin (Compound) and Idarubicin may lead to a major life threatening interaction when taken with Smallpox (Vaccinia) Vacc... |
DB00279 | DB14491 | 1,152 | 428 | [
"DDInter1074",
"DDInter725"
] | Liothyronine | Ferrous fumarate | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | Used in treatment of iron deficiency anemia. | Moderate | 1 | [
[
[
1152,
24,
428
]
],
[
[
1152,
24,
379
],
[
379,
24,
428
]
],
[
[
1152,
1,
1191
],
[
1191,
24,
428
]
],
[
[
1152,
63,
837
],
[
837,
... | [
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous fumarate"
]
],
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rabeprazole"
... | Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Rabeprazole and Rabeprazole may cause a moderate interaction that could exacerbate diseases when taken with Ferrous fumarate
Liothyronine (Compound) resembles Levodopa (Compound) and Levodopa may cause a moderate interaction th... |
DB00023 | DB01015 | 305 | 1,247 | [
"DDInter127",
"DDInter1724"
] | Asparaginase Escherichia coli | Sulfamethoxazole | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps i... | Moderate | 1 | [
[
[
305,
24,
1247
]
],
[
[
305,
24,
1029
],
[
1029,
1,
1247
]
],
[
[
305,
25,
1011
],
[
1011,
62,
1247
]
],
[
[
305,
24,
484
],
[
484,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfamethoxazole"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken w... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Sulfisoxazole and Sulfisoxazole (Compound) resembles Sulfamethoxazole (Compound)
Asparaginase Escherichia coli may lead to a major life threatening interaction when taken with Fingolimod and Fingolimod may caus... |
DB00289 | DB00637 | 847 | 1,557 | [
"DDInter132",
"DDInter128"
] | Atomoxetine | Astemizole | Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD). Also known as the marketed product Strattera, atomoxetine is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve develop... | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Moderate | 1 | [
[
[
847,
24,
1557
]
],
[
[
847,
6,
8374
],
[
8374,
45,
1557
]
],
[
[
847,
40,
307
],
[
307,
62,
1557
]
],
[
[
847,
23,
112
],
[
112,
... | [
[
[
"Atomoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Astemizole"
]
],
[
[
"Atomoxetine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Atomoxetine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Astemizole (Compound)
Atomoxetine (Compound) resembles Modafinil (Compound) and Modafinil may cause a minor interaction that can limit clinical effects when taken with Astemizole
Atomoxetine may cause a minor interaction that can limit clinical ef... |
DB00552 | DB14444 | 1,238 | 151 | [
"DDInter1425",
"DDInter924"
] | Pentostatin | Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) | A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immuno... | Moderate | 1 | [
[
[
1238,
24,
151
]
],
[
[
1238,
63,
66
],
[
66,
24,
151
]
],
[
[
1238,
24,
869
],
[
869,
24,
151
]
],
[
[
1238,
25,
375
],
[
375,
2... | [
[
[
"Pentostatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)"
]
],
[
[
"Pentostatin",
"{u} may cause a moderate interaction that could... | Pentostatin may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Pentostatin may cause a moderate int... |
DB01118 | DB08904 | 33 | 375 | [
"DDInter76",
"DDInter342"
] | Amiodarone | Certolizumab pegol | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Moderate | 1 | [
[
[
33,
24,
375
]
],
[
[
33,
24,
1047
],
[
1047,
24,
375
]
],
[
[
33,
24,
1434
],
[
1434,
63,
375
]
],
[
[
33,
25,
1593
],
[
1593,
2... | [
[
[
"Amiodarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Amiodarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trastuzumab emtansi... | Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab emtansine and Trastuzumab emtansine may cause a moderate interaction that could exacerbate diseases when taken with Certolizumab pegol
Amiodarone may cause a moderate interaction that could exacerbate diseases when ta... |
DB08820 | DB12500 | 1,478 | 283 | [
"DDInter997",
"DDInter714"
] | Ivacaftor | Fedratinib | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Major | 2 | [
[
[
1478,
25,
283
]
],
[
[
1478,
23,
271
],
[
271,
23,
283
]
],
[
[
1478,
25,
351
],
[
351,
23,
283
]
],
[
[
1478,
64,
122
],
[
122,
... | [
[
[
"Ivacaftor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
]
],
[
[
"Ivacaftor",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mirabegron"
],
[
"Mirabegron",
... | Ivacaftor may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Ivacaftor may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause a mino... |
DB00227 | DB08901 | 1,463 | 1,468 | [
"DDInter1098",
"DDInter1492"
] | Lovastatin | Ponatinib | Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disea... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
1463,
24,
1468
]
],
[
[
1463,
24,
478
],
[
478,
24,
1468
]
],
[
[
1463,
6,
12523
],
[
12523,
45,
1468
]
],
[
[
1463,
7,
2493
],
[
2493... | [
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
... | Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Lovastatin (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Ponatinib (Compound)
Lovastatin (Compound) ... |
DB01045 | DB05239 | 463 | 866 | [
"DDInter1590",
"DDInter425"
] | Rifampicin | Cobimetinib | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Major | 2 | [
[
[
463,
25,
866
]
],
[
[
463,
25,
214
],
[
214,
63,
866
]
],
[
[
463,
63,
888
],
[
888,
24,
866
]
],
[
[
463,
24,
1069
],
[
1069,
6... | [
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobimetinib"
]
],
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fostamatinib"
],
[
"Fostamatinib",
"... | Rifampicin may lead to a major life threatening interaction when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Cobimetinib
Rifampicin may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen may cau... |
DB04855 | DB05294 | 540 | 1,069 | [
"DDInter602",
"DDInter1917"
] | Dronedarone | Vandetanib | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Major | 2 | [
[
[
540,
25,
1069
]
],
[
[
540,
63,
883
],
[
883,
40,
1069
]
],
[
[
540,
6,
1829
],
[
1829,
45,
1069
]
],
[
[
540,
21,
29343
],
[
29343,
... | [
[
[
"Dronedarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vandetanib"
]
],
[
[
"Dronedarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
"Gefitinib... | Dronedarone may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Vandetanib (Compound)
Dronedarone (Compound) binds ALB (Gene) and ALB (Gene) is bound by Vandetanib (Compound)
Dronedarone (Compound) causes Blood creatinine increased (Side Effect) a... |
DB00026 | DB00188 | 1,184 | 168 | [
"DDInter94",
"DDInter222"
] | Anakinra | Bortezomib | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Moderate | 1 | [
[
[
1184,
24,
168
]
],
[
[
1184,
24,
1307
],
[
1307,
62,
168
]
],
[
[
1184,
24,
33
],
[
33,
63,
168
]
],
[
[
1184,
24,
58
],
[
58,
2... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Melphalan"
],
[
"... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Melphalan and Melphalan may cause a minor interaction that can limit clinical effects when taken with Bortezomib
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Amiodarone and Amiodarone may... |
DB00033 | DB00307 | 342 | 1,101 | [
"DDInter949",
"DDInter202"
] | Interferon gamma-1b | Bexarotene | Human Interferon gamma-1b (140 residues), produced from E. coli. Production of Actimmune is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. Purification of the product is achieved by conventional column chromatography. The sequence ... | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Major | 2 | [
[
[
342,
25,
1101
]
],
[
[
342,
24,
597
],
[
597,
62,
1101
]
],
[
[
342,
24,
1253
],
[
1253,
24,
1101
]
],
[
[
342,
24,
322
],
[
322,
... | [
[
[
"Interferon gamma-1b",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
]
],
[
[
"Interferon gamma-1b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphenicol"
],
... | Interferon gamma-1b may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol may cause a minor interaction that can limit clinical effects when taken with Bexarotene
Interferon gamma-1b may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00697 | DB00757 | 876 | 1,166 | [
"DDInter1821",
"DDInter581"
] | Tizanidine | Dolasetron | Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury. It may also be caused by musculoskeletal injury. Regardless of the cause, muscle spasticity can be an extremely painful and debili... | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Major | 2 | [
[
[
876,
25,
1166
]
],
[
[
876,
63,
19
],
[
19,
40,
1166
]
],
[
[
876,
63,
85
],
[
85,
1,
1166
]
],
[
[
876,
21,
28803
],
[
28803,
6... | [
[
[
"Tizanidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dolasetron"
]
],
[
[
"Tizanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
[
"Hyoscyami... | Tizanidine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine (Compound) resembles Dolasetron (Compound)
Tizanidine may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine (Compound) resembles Dolasetron (Compound)
Ti... |
DB00341 | DB01041 | 1,242 | 770 | [
"DDInter343",
"DDInter1789"
] | Cetirizine | Thalidomide | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
1242,
24,
770
]
],
[
[
1242,
21,
28789
],
[
28789,
60,
770
]
],
[
[
1242,
24,
849
],
[
849,
63,
770
]
],
[
[
1242,
24,
1533
],
[
1533,... | [
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Cetirizine",
"{u} (Compound) causes {v} (Side Effect)",
"Loss of consciousness"
],
[
"Loss of consciousness",
"... | Cetirizine (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Thalidomide (Compound)
Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate disease... |
DB00938 | DB06176 | 455 | 1,342 | [
"DDInter1635",
"DDInter1616"
] | Salmeterol | Romidepsin | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Moderate | 1 | [
[
[
455,
24,
1342
]
],
[
[
455,
24,
956
],
[
956,
24,
1342
]
],
[
[
455,
63,
485
],
[
485,
24,
1342
]
],
[
[
455,
24,
1616
],
[
1616,
... | [
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romidepsin"
]
],
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norfloxacin"
],
[
... | Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Norfloxacin and Norfloxacin may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin
Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine and Pen... |
DB01192 | DB01233 | 560 | 1,311 | [
"DDInter1372",
"DDInter1197"
] | Oxymorphone | Metoclopramide | An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092). O... | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Moderate | 1 | [
[
[
560,
24,
1311
]
],
[
[
560,
6,
12523
],
[
12523,
45,
1311
]
],
[
[
560,
21,
28691
],
[
28691,
60,
1311
]
],
[
[
560,
24,
1383
],
[
138... | [
[
[
"Oxymorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
]
],
[
[
"Oxymorphone",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compo... | Oxymorphone (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Metoclopramide (Compound)
Oxymorphone (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Metoclopramide (Compound)
Oxymorphone may cause a moderate interaction that could exacerbate diseases when taken with Sodium... |
DB00365 | DB00563 | 839 | 663 | [
"DDInter842",
"DDInter1174"
] | Grepafloxacin | Methotrexate | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Moderate | 1 | [
[
[
839,
24,
663
]
],
[
[
839,
23,
328
],
[
328,
62,
663
]
],
[
[
839,
25,
126
],
[
126,
62,
663
]
],
[
[
839,
24,
1475
],
[
1475,
6... | [
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
]
],
[
[
"Grepafloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mercaptopurine"
]... | Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Mercaptopurine and Mercaptopurine may cause a minor interaction that can limit clinical effects when taken with Methotrexate
Grepafloxacin may lead to a major life threatening interaction when taken with Warfarin and Warfarin ma... |
DB00727 | DB09112 | 685 | 1,455 | [
"DDInter1304",
"DDInter1306"
] | Nitroglycerin | Nitrous acid | Nitroglycerin, also known as glyceryl trinitrate, is an organic nitrate and a vasodilating agent that was first discovered in 1847. Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure ex... | Nitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. There is also research to investigate its applica... | Major | 2 | [
[
[
685,
25,
1455
]
],
[
[
685,
24,
1450
],
[
1450,
24,
1455
]
],
[
[
685,
24,
433
],
[
433,
63,
1455
]
],
[
[
685,
63,
1061
],
[
1061,
... | [
[
[
"Nitroglycerin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nitrous acid"
]
],
[
[
"Nitroglycerin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
],
[
... | Nitroglycerin may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Nitrous acid
Nitroglycerin may cause a moderate interaction that could exacerbate diseases when taken with Ertugli... |
DB00938 | DB01599 | 455 | 1,232 | [
"DDInter1635",
"DDInter1523"
] | Salmeterol | Probucol | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993). | Moderate | 1 | [
[
[
455,
24,
1232
]
],
[
[
455,
63,
1555
],
[
1555,
24,
1232
]
],
[
[
455,
24,
927
],
[
927,
63,
1232
]
],
[
[
455,
24,
77
],
[
77,
... | [
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Probucol"
]
],
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin"
],
[
... | Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Probucol
Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encor... |
DB00400 | DB11703 | 353 | 405 | [
"DDInter843",
"DDInter9"
] | Griseofulvin | Acalabrutinib | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Moderate | 1 | [
[
[
353,
24,
405
]
],
[
[
353,
62,
1101
],
[
1101,
24,
405
]
],
[
[
353,
24,
951
],
[
951,
24,
405
]
],
[
[
353,
24,
1598
],
[
1598,
... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Griseofulvin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bexarotene"
],
... | Griseofulvin may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib and ... |
DB00554 | DB09030 | 1,027 | 840 | [
"DDInter1478",
"DDInter1945"
] | Piroxicam | Vorapaxar | A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. | Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expr... | Major | 2 | [
[
[
1027,
25,
840
]
],
[
[
1027,
24,
885
],
[
885,
24,
840
]
],
[
[
1027,
24,
1017
],
[
1017,
63,
840
]
],
[
[
1027,
63,
1061
],
[
1061,
... | [
[
[
"Piroxicam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vorapaxar"
]
],
[
[
"Piroxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
],
[
"Epoprosteno... | Piroxicam may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Vorapaxar
Piroxicam may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorla... |
DB00023 | DB01197 | 305 | 1,603 | [
"DDInter127",
"DDInter292"
] | Asparaginase Escherichia coli | Captopril | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment ... | Moderate | 1 | [
[
[
305,
24,
1603
]
],
[
[
305,
24,
610
],
[
610,
1,
1603
]
],
[
[
305,
24,
1179
],
[
1179,
24,
1603
]
],
[
[
305,
24,
1254
],
[
1254,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Captopril"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Enalapril and Enalapril (Compound) resembles Captopril (Compound)
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Insulin lispro and Insulin lispro ... |
DB09065 | DB13007 | 760 | 1,060 | [
"DDInter424",
"DDInter642"
] | Cobicistat | Enfortumab vedotin | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Enfortumab vedotin is an antibody-drug conjugate used in the treatment of patients with advanced, treatment-resistant urothelial cancers. It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting chemotherapeutic agent, monomethyl auristatin E (MMAE), joined by a protea... | Major | 2 | [
[
[
760,
25,
1060
]
],
[
[
760,
64,
129
],
[
129,
23,
1060
]
],
[
[
760,
25,
913
],
[
913,
23,
1060
]
],
[
[
760,
64,
1593
],
[
1593,
... | [
[
[
"Cobicistat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enfortumab vedotin"
]
],
[
[
"Cobicistat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
],
[
"Enzalutamide",
... | Cobicistat may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Enfortumab vedotin
Cobicistat may lead to a major life threatening interaction when taken with Apalutamide and Apalutamide may cause a m... |
DB00656 | DB01611 | 827 | 1,487 | [
"DDInter1851",
"DDInter893"
] | Trazodone | Hydroxychloroquine | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Major | 2 | [
[
[
827,
25,
1487
]
],
[
[
827,
24,
1520
],
[
1520,
25,
1487
]
],
[
[
827,
6,
12523
],
[
12523,
45,
1487
]
],
[
[
827,
21,
28658
],
[
2865... | [
[
[
"Trazodone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Trazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
],
[
"Prim... | Trazodone may cause a moderate interaction that could exacerbate diseases when taken with Primaquine and Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Trazodone (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Hydroxychloroquine (Compound)
Trazodone (Compound... |
DB00353 | DB09065 | 588 | 760 | [
"DDInter1187",
"DDInter424"
] | Methylergometrine | Cobicistat | A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed) | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Major | 2 | [
[
[
588,
25,
760
]
],
[
[
588,
63,
1101
],
[
1101,
23,
760
]
],
[
[
588,
24,
1374
],
[
1374,
23,
760
]
],
[
[
588,
24,
723
],
[
723,
... | [
[
[
"Methylergometrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobicistat"
]
],
[
[
"Methylergometrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Methylergometrine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Methylergometrine may cause a moderate interaction that could exacerbate diseases when taken with Abiratero... |
DB00451 | DB06723 | 542 | 115 | [
"DDInter1064",
"DDInter58"
] | Levothyroxine | Aluminum hydroxide | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | Moderate | 1 | [
[
[
542,
24,
115
]
],
[
[
542,
21,
28882
],
[
28882,
60,
115
]
],
[
[
542,
24,
1482
],
[
1482,
23,
115
]
],
[
[
542,
63,
1252
],
[
1252,
... | [
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aluminum hydroxide"
]
],
[
[
"Levothyroxine",
"{u} (Compound) causes {v} (Side Effect)",
"Body temperature increased"
],
[
"Body temperat... | Levothyroxine (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Aluminum hydroxide (Compound)
Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Digitoxin and Digitoxin may cause a minor interaction that can li... |
DB01619 | DB11732 | 830 | 1,097 | [
"DDInter1441",
"DDInter1027"
] | Phenindamine | Lasmiditan | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Lasmiditan is an oral medication used in the termination of migraine headaches that was first approved for use in the United States in October 2019.[L9338,L9356] It was also approved by the European Commission on August 17, 2022. Traditionally, the triptan class of anti-migraine medications (e.g. [sumatriptan]) have se... | Moderate | 1 | [
[
[
830,
24,
1097
]
],
[
[
830,
63,
701
],
[
701,
24,
1097
]
],
[
[
830,
24,
407
],
[
407,
24,
1097
]
],
[
[
830,
1,
537
],
[
537,
2... | [
[
[
"Phenindamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lasmiditan"
]
],
[
[
"Phenindamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
... | Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Lasmiditan
Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium m... |
DB01234 | DB09020 | 1,220 | 28 | [
"DDInter513",
"DDInter212"
] | Dexamethasone | Bisacodyl | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
1220,
24,
28
]
],
[
[
1220,
18,
20113
],
[
20113,
46,
28
]
],
[
[
1220,
7,
3724
],
[
3724,
46,
28
]
],
[
[
1220,
6,
9842
],
[
9842,
... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Dexamethasone",
"{u} (Compound) downregulates {v} (Gene)",
"IER3"
],
[
"IER3",
"{u} (Gene) is upregulated by {... | Dexamethasone (Compound) downregulates IER3 (Gene) and IER3 (Gene) is upregulated by Bisacodyl (Compound)
Dexamethasone (Compound) upregulates CDK5R1 (Gene) and CDK5R1 (Gene) is upregulated by Bisacodyl (Compound)
Dexamethasone (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is upregulated by Bisacodyl (Compound)
Dexa... |
DB00220 | DB00637 | 798 | 1,557 | [
"DDInter1276",
"DDInter128"
] | Nelfinavir | Astemizole | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Major | 2 | [
[
[
798,
25,
1557
]
],
[
[
798,
6,
21998
],
[
21998,
45,
1557
]
],
[
[
798,
18,
5833
],
[
5833,
46,
1557
]
],
[
[
798,
7,
7669
],
[
7669,
... | [
[
[
"Nelfinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Astemizole"
]
],
[
[
"Nelfinavir",
"{u} (Compound) binds {v} (Gene)",
"CYP3A7-CYP3A51P"
],
[
"CYP3A7-CYP3A51P",
"{u} (Gene) is bound by {v} (Compound... | Nelfinavir (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Astemizole (Compound)
Nelfinavir (Compound) downregulates ACAT2 (Gene) and ACAT2 (Gene) is upregulated by Astemizole (Compound)
Nelfinavir (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Astemizole (Compound... |
DB00218 | DB00631 | 1,176 | 372 | [
"DDInter1247",
"DDInter405"
] | Moxifloxacin | Clofarabine | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Moderate | 1 | [
[
[
1176,
24,
372
]
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[
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1176,
23,
1488
],
[
1488,
40,
372
]
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[
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6,
3199
],
[
3199,
57,
372
]
],
[
[
1176,
21,
28903
],
[
28903... | [
[
[
"Moxifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
]
],
[
[
"Moxifloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Fludarabine"
],
... | Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Fludarabine and Fludarabine (Compound) resembles Clofarabine (Compound)
Moxifloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is downregulated by Clofarabine (Compound)
Moxifloxacin (Compound) causes Dry skin (Side Effect) ... |
DB00867 | DB08868 | 1,052 | 1,011 | [
"DDInter1606",
"DDInter737"
] | Ritodrine | Fingolimod | Adrenergic beta-agonist used to control premature labor. | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Moderate | 1 | [
[
[
1052,
24,
1011
]
],
[
[
1052,
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[
144,
63,
1011
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[
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35,
480
],
[
480,
24,
1011
]
],
[
[
1052,
24,
455
],
[
455,
... | [
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fingolimod"
]
],
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
],
[
... | Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol and Olodaterol may cause a moderate interaction that could exacerbate diseases when taken with Fingolimod
Ritodrine (Compound) resembles Formoterol (Compound) and Ritodrine may cause a moderate interaction that could ex... |
DB01132 | DB09061 | 1,130 | 1,627 | [
"DDInter1472",
"DDInter284"
] | Pioglitazone | Cannabidiol | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
1130,
24,
1627
]
],
[
[
1130,
63,
723
],
[
723,
23,
1627
]
],
[
[
1130,
24,
609
],
[
609,
23,
1627
]
],
[
[
1130,
24,
351
],
[
351,
... | [
[
[
"Pioglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Pioglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
... | Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a minor interaction that can limit clinical effects when taken with Cannabidiol
Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and... |
DB00539 | DB09104 | 11 | 286 | [
"DDInter1837",
"DDInter1118"
] | Toremifene | Magnesium hydroxide | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
11,
24,
286
]
],
[
[
11,
25,
820
],
[
820,
23,
286
]
],
[
[
11,
63,
752
],
[
752,
23,
286
]
],
[
[
11,
24,
1559
],
[
1559,
23,
... | [
[
[
"Toremifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alimemazine"
],
[
"... | Toremifene may lead to a major life threatening interaction when taken with Alimemazine and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Toremifene may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cimetidine m... |
DB00884 | DB00945 | 1,008 | 1,479 | [
"DDInter1604",
"DDInter20"
] | Risedronic acid | Acetylsalicylic acid | Risedronic acid is a third generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label]. | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Moderate | 1 | [
[
[
1008,
24,
1479
]
],
[
[
1008,
6,
7720
],
[
7720,
45,
1479
]
],
[
[
1008,
21,
28931
],
[
28931,
60,
1479
]
],
[
[
1008,
24,
1283
],
[
1... | [
[
[
"Risedronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
]
],
[
[
"Risedronic acid",
"{u} (Compound) binds {v} (Gene)",
"PTGS2"
],
[
"PTGS2",
"{u} (Gene) is bound b... | Risedronic acid (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Acetylsalicylic acid (Compound)
Risedronic acid (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Acetylsalicylic acid (Compound)
Risedronic acid may cause a moderate interaction that could exacerbate disease... |
DB00060 | DB06273 | 912 | 980 | [
"DDInter947",
"DDInter1824"
] | Interferon beta-1a | Tocilizumab | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Moderate | 1 | [
[
[
912,
24,
980
]
],
[
[
912,
25,
139
],
[
139,
24,
980
]
],
[
[
912,
24,
975
],
[
975,
63,
980
]
],
[
[
912,
24,
1031
],
[
1031,
2... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocilizumab"
]
],
[
[
"Interferon beta-1a",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zidovudine"
],
[
... | Interferon beta-1a may lead to a major life threatening interaction when taken with Zidovudine and Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Tocilizumab
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin and L... |
DB00687 | DB11988 | 870 | 270 | [
"DDInter747",
"DDInter1321"
] | Fludrocortisone | Ocrelizumab | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
870,
24,
270
]
],
[
[
870,
24,
713
],
[
713,
24,
270
]
],
[
[
870,
1,
175
],
[
175,
24,
270
]
],
[
[
870,
24,
287
],
[
287,
63,
... | [
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarat... | Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate and Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab
Fludrocortisone (Compound) resembles Triamcinolone (Compound) and Triamcinolone may cause a ... |
DB04844 | DB11718 | 843 | 927 | [
"DDInter1778",
"DDInter640"
] | Tetrabenazine | Encorafenib | A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008. | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
843,
24,
927
]
],
[
[
843,
62,
112
],
[
112,
23,
927
]
],
[
[
843,
24,
720
],
[
720,
24,
927
]
],
[
[
843,
63,
1520
],
[
1520,
2... | [
[
[
"Tetrabenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Tetrabenazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Tetrabenazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Encorafenib
Tetrabenazine may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil ... |
DB00554 | DB00620 | 1,027 | 175 | [
"DDInter1478",
"DDInter1855"
] | Piroxicam | Triamcinolone | A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Moderate | 1 | [
[
[
1027,
24,
175
]
],
[
[
1027,
24,
1573
],
[
1573,
1,
175
]
],
[
[
1027,
24,
617
],
[
617,
40,
175
]
],
[
[
1027,
63,
251
],
[
251,
... | [
[
[
"Piroxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
]
],
[
[
"Piroxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
],
[
... | Piroxicam may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone (Compound) resembles Triamcinolone (Compound)
Piroxicam may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and Budesonide (Compound) resembles Triamcinolone (Compou... |
DB00215 | DB00662 | 1,230 | 717 | [
"DDInter388",
"DDInter1873"
] | Citalopram | Trimethobenzamide | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against e... | Moderate | 1 | [
[
[
1230,
24,
717
]
],
[
[
1230,
25,
1425
],
[
1425,
40,
717
]
],
[
[
1230,
21,
29648
],
[
29648,
60,
717
]
],
[
[
1230,
24,
1594
],
[
159... | [
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimethobenzamide"
]
],
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cisapride"
],
[
"Cisa... | Citalopram may lead to a major life threatening interaction when taken with Cisapride and Cisapride (Compound) resembles Trimethobenzamide (Compound)
Citalopram (Compound) causes Disorientation (Side Effect) and Disorientation (Side Effect) is caused by Trimethobenzamide (Compound)
Citalopram may cause a moderate inter... |
DB01129 | DB09143 | 379 | 313 | [
"DDInter1559",
"DDInter1701"
] | Rabeprazole | Sonidegib | Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion. | Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) developed as an anticancer agent by Novartis. It was FDA approved in 2015 for the treatment of basal cell carcinoma. | Minor | 0 | [
[
[
379,
23,
313
]
],
[
[
379,
40,
837
],
[
837,
23,
313
]
],
[
[
379,
1,
1215
],
[
1215,
23,
313
]
],
[
[
379,
24,
478
],
[
478,
24... | [
[
[
"Rabeprazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sonidegib"
]
],
[
[
"Rabeprazole",
"{u} (Compound) resembles {v} (Compound)",
"Pantoprazole"
],
[
"Pantoprazole",
"{u} may cause a mino... | Rabeprazole (Compound) resembles Pantoprazole (Compound) and Pantoprazole may cause a minor interaction that can limit clinical effects when taken with Sonidegib
Rabeprazole (Compound) resembles Lansoprazole (Compound) and Lansoprazole may cause a minor interaction that can limit clinical effects when taken with Sonide... |
DB00321 | DB01075 | 21 | 1,376 | [
"DDInter78",
"DDInter569"
] | Amitriptyline | Diphenhydramine | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
21,
35,
1376
]
],
[
[
21,
24,
649
],
[
649,
63,
1376
]
],
[
[
21,
25,
11
],
[
11,
1,
1376
]
],
[
[
21,
24,
128
],
[
128,
24,
... | [
[
[
"Amitriptyline",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases w... | Amitriptyline (Compound) resembles Diphenhydramine (Compound) and
Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Amitriptyline may lead to a major life... |
DB00976 | DB11967 | 1,056 | 710 | [
"DDInter1758",
"DDInter210"
] | Telithromycin | Binimetinib | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Binimetinib, also known as _Mektovi_, is a potent and selective oral mitogen-activated protein kinase 1/2 (MEK 1/2) inhibitor which is combined with [Encorafenib].[A34275,L3335] On June 27, 2018, the Food and Drug Administration approved the combination of [Encorafenib] and binimetinib (BRAFTOVI and MEKTOVI, from Array... | Moderate | 1 | [
[
[
1056,
24,
710
]
],
[
[
1056,
25,
1593
],
[
1593,
24,
710
]
],
[
[
1056,
64,
1557
],
[
1557,
24,
710
]
],
[
[
1056,
63,
883
],
[
883,
... | [
[
[
"Telithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Binimetinib"
]
],
[
[
"Telithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
],
[
"Cri... | Telithromycin may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Binimetinib
Telithromycin may lead to a major life threatening interaction when taken with Astemizole and Astemizole may cause a modera... |
DB00604 | DB06448 | 1,425 | 171 | [
"DDInter385",
"DDInter1087"
] | Cisapride | Lonafarnib | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Major | 2 | [
[
[
1425,
25,
171
]
],
[
[
1425,
25,
888
],
[
888,
24,
171
]
],
[
[
1425,
23,
112
],
[
112,
24,
171
]
],
[
[
1425,
64,
1424
],
[
1424,
... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lonafarnib"
]
],
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tamoxifen"
],
[
"Tamoxifen",
"{u} may c... | Cisapride may lead to a major life threatening interaction when taken with Tamoxifen and Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Lonafarnib
Cisapride may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause ... |
DB00514 | DB01118 | 506 | 33 | [
"DDInter527",
"DDInter76"
] | Dextromethorphan | Amiodarone | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Moderate | 1 | [
[
[
506,
24,
33
]
],
[
[
506,
24,
540
],
[
540,
1,
33
]
],
[
[
506,
6,
3486
],
[
3486,
45,
33
]
],
[
[
506,
7,
5727
],
[
5727,
46,
... | [
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiodarone"
]
],
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronedarone"
... | Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Dronedarone and Dronedarone (Compound) resembles Amiodarone (Compound)
Dextromethorphan (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Amiodarone (Compound)
Dextromethorphan (Compound) upregulates AGR2 (Gene) ... |
DB00289 | DB01075 | 847 | 1,376 | [
"DDInter132",
"DDInter569"
] | Atomoxetine | Diphenhydramine | Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD). Also known as the marketed product Strattera, atomoxetine is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve develop... | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
847,
24,
1376
]
],
[
[
847,
40,
649
],
[
649,
63,
1376
]
],
[
[
847,
25,
11
],
[
11,
1,
1376
]
],
[
[
847,
40,
11314
],
[
11314,
... | [
[
[
"Atomoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Atomoxetine",
"{u} (Compound) resembles {v} (Compound)",
"Clofedanol"
],
[
"Clofedanol",
"{u} may cause a ... | Atomoxetine (Compound) resembles Clofedanol (Compound) and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Atomoxetine may lead to a major life threatening interaction when taken with Toremifene and Toremifene (Compound) resembles Diphenhydramine (Compound)
Ato... |
DB00361 | DB04865 | 134 | 4 | [
"DDInter1939",
"DDInter1335"
] | Vinorelbine | Omacetaxine mepesuccinate | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
134,
24,
4
]
],
[
[
134,
7,
2025
],
[
2025,
46,
4
]
],
[
[
134,
18,
3891
],
[
3891,
46,
4
]
],
[
[
134,
18,
10488
],
[
10488,
57... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Vinorelbine",
"{u} (Compound) upregulates {v} (Gene)",
"ETS1"
],
[
"ETS1",
"{u} (Gene) is upregu... | Vinorelbine (Compound) upregulates ETS1 (Gene) and ETS1 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Vinorelbine (Compound) downregulates KAT6A (Gene) and KAT6A (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Vinorelbine (Compound) downregulates B4GAT1 (Gene) and B4GAT1 (Gene) is downregu... |
DB00877 | DB11003 | 629 | 748 | [
"DDInter1678",
"DDInter100"
] | Sirolimus | Anthrax vaccine | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsula... | Moderate | 1 | [
[
[
629,
24,
748
]
],
[
[
629,
63,
896
],
[
896,
24,
748
]
],
[
[
629,
25,
676
],
[
676,
63,
748
]
],
[
[
629,
24,
1683
],
[
1683,
2... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
],
[
... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine
Sirolimus may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib may c... |
DB00330 | DB00563 | 238 | 663 | [
"DDInter689",
"DDInter1174"
] | Ethambutol | Methotrexate | Ethambutol is a bacteriostatic agent indicated alongside medications such as [isoniazid], [rifampin], and [pyrazinamide] in the treatment of pulmonary tuberculosis. Ethambutol was first described in the literature in 1961. It was developed out of a need for therapies active against isoniazid resistant strains of _Mycob... | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Moderate | 1 | [
[
[
238,
24,
663
]
],
[
[
238,
21,
28681
],
[
28681,
60,
663
]
],
[
[
238,
24,
1487
],
[
1487,
62,
663
]
],
[
[
238,
24,
589
],
[
589,
... | [
[
[
"Ethambutol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
]
],
[
[
"Ethambutol",
"{u} (Compound) causes {v} (Side Effect)",
"Hypersensitivity"
],
[
"Hypersensitivity",
"{u} (Side... | Ethambutol (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Methotrexate (Compound)
Ethambutol may cause a moderate interaction that could exacerbate diseases when taken with Hydroxychloroquine and Hydroxychloroquine may cause a minor interaction that can limit clinical e... |
DB00598 | DB00983 | 1,523 | 480 | [
"DDInter1013",
"DDInter776"
] | Labetalol | Formoterol | Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture. Labetalol is formulated as an injection or tablets to treat hypertension.[L7727,L7730] Labetalol was granted FDA approval on 1 August 1984. | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Major | 2 | [
[
[
1523,
25,
480
]
],
[
[
1523,
24,
1148
],
[
1148,
63,
480
]
],
[
[
1523,
40,
11540
],
[
11540,
40,
480
]
],
[
[
1523,
40,
1188
],
[
118... | [
[
[
"Labetalol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Formoterol"
]
],
[
[
"Labetalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
[
"Isoprenali... | Labetalol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Formoterol
Labetalol (Compound) resembles Fenoterol (Compound) and Fenoterol (Compound) resembles Formoterol (Compound)
... |
DB00414 | DB09038 | 590 | 1,450 | [
"DDInter16",
"DDInter636"
] | Acetohexamide | Empagliflozin | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
590,
24,
1450
]
],
[
[
590,
62,
1103
],
[
1103,
23,
1450
]
],
[
[
590,
63,
461
],
[
461,
24,
1450
]
],
[
[
590,
24,
485
],
[
485,
... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Acetohexamide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
],
... | Acetohexamide may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Empagliflozin
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Timolol and Timo... |
DB01259 | DB06228 | 392 | 792 | [
"DDInter1024",
"DDInter1609"
] | Lapatinib | Rivaroxaban | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Moderate | 1 | [
[
[
392,
24,
792
]
],
[
[
392,
6,
4973
],
[
4973,
45,
792
]
],
[
[
392,
18,
4602
],
[
4602,
57,
792
]
],
[
[
392,
21,
28703
],
[
28703,
... | [
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Lapatinib",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Lapatinib (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Rivaroxaban (Compound)
Lapatinib (Compound) downregulates SUPV3L1 (Gene) and SUPV3L1 (Gene) is downregulated by Rivaroxaban (Compound)
Lapatinib (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Rivaroxaban (Compound)
La... |
DB00762 | DB09118 | 613 | 1,580 | [
"DDInter973",
"DDInter1711"
] | Irinotecan | Stiripentol | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Moderate | 1 | [
[
[
613,
24,
1580
]
],
[
[
613,
24,
466
],
[
466,
62,
1580
]
],
[
[
613,
24,
283
],
[
283,
63,
1580
]
],
[
[
613,
24,
98
],
[
98,
24... | [
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stiripentol"
]
],
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[... | Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Stiripentol
Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fed... |
DB00047 | DB00363 | 176 | 695 | [
"DDInter932",
"DDInter419"
] | Insulin glargine | Clozapine | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Moderate | 1 | [
[
[
176,
24,
695
]
],
[
[
176,
24,
1178
],
[
1178,
1,
695
]
],
[
[
176,
24,
623
],
[
623,
40,
695
]
],
[
[
176,
23,
274
],
[
274,
63... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clozapine"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Clozapine (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Quetiapine and Quetiapine (Compound) resembles C... |
DB00710 | DB01099 | 1,199 | 1,272 | [
"DDInter897",
"DDInter744"
] | Ibandronate | Flucytosine | Ibandronate, or BM 21.0955, is a third generation, nitrogen containing bisphosphonate similar to [zoledronic acid], [minodronic acid], and [risedronic acid].[A203111,A203138] It is used to prevent and treat postmenopausal osteoporosis.[L13805,L13808] Ibandronate was first described in the literature in 1993 as a treatm... | A fluorinated cytosine analog that is used as an antifungal agent. | Moderate | 1 | [
[
[
1199,
24,
1272
]
],
[
[
1199,
21,
28787
],
[
28787,
60,
1272
]
],
[
[
1199,
24,
485
],
[
485,
24,
1272
]
],
[
[
1199,
63,
1441
],
[
14... | [
[
[
"Ibandronate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flucytosine"
]
],
[
[
"Ibandronate",
"{u} (Compound) causes {v} (Side Effect)",
"Dermatitis"
],
[
"Dermatitis",
"{u} (Side Effect) is... | Ibandronate (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Flucytosine (Compound)
Ibandronate may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine and Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00350 | DB09038 | 1,214 | 1,450 | [
"DDInter1226",
"DDInter636"
] | Minoxidil | Empagliflozin | A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure. | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
1214,
24,
1450
]
],
[
[
1214,
24,
1061
],
[
1061,
24,
1450
]
],
[
[
1214,
24,
1455
],
[
1455,
63,
1450
]
],
[
[
1214,
23,
402
],
[
402... | [
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
[... | Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Nitrous acid and... |
DB05381 | DB09488 | 172 | 103 | [
"DDInter863",
"DDInter23"
] | Histamine | Acrivastine | A depressor amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter. | Acrivastine is a triprolidine analog antihistamine indicated for the treatment of allergies and hay fever. As an H1 receptor antagonist, it functions by blocking the action of histamine at this receptor thereby preventing the symptoms associated with histamine release such as pruritis, vasodilation, hypotension, edema,... | Moderate | 1 | [
[
[
172,
24,
103
]
],
[
[
172,
63,
413
],
[
413,
24,
103
]
],
[
[
172,
24,
849
],
[
849,
24,
103
]
],
[
[
172,
24,
337
],
[
337,
63,... | [
[
[
"Histamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acrivastine"
]
],
[
[
"Histamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Maprotiline"
],
[
... | Histamine may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline and Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Acrivastine
Histamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyr... |
DB00531 | DB01033 | 450 | 328 | [
"DDInter456",
"DDInter1156"
] | Cyclophosphamide | Mercaptopurine | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. | Moderate | 1 | [
[
[
450,
24,
328
]
],
[
[
450,
21,
28681
],
[
28681,
60,
328
]
],
[
[
450,
23,
1299
],
[
1299,
23,
328
]
],
[
[
450,
23,
945
],
[
945,
... | [
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mercaptopurine"
]
],
[
[
"Cyclophosphamide",
"{u} (Compound) causes {v} (Side Effect)",
"Hypersensitivity"
],
[
"Hypersensitivity",
... | Cyclophosphamide (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Mercaptopurine (Compound)
Cyclophosphamide may cause a minor interaction that can limit clinical effects when taken with Trovafloxacin and Trovafloxacin may cause a minor interaction that can limit clinical... |
DB06016 | DB08899 | 1,508 | 129 | [
"DDInter300",
"DDInter649"
] | Cariprazine | Enzalutamide | Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary. It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT<sub>1A</sub> receptors and as an antagonist at serotonin 5-HT<sub>2A</sub> receptors. Cariprazine has been investigated in... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
1508,
24,
129
]
],
[
[
1508,
63,
918
],
[
918,
1,
129
]
],
[
[
1508,
24,
1320
],
[
1320,
63,
129
]
],
[
[
1508,
63,
959
],
[
959,
... | [
[
[
"Cariprazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Cariprazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
],
... | Cariprazine may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Cariprazine may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elagolix may cause a moderate interaction that c... |
DB08911 | DB12147 | 1,556 | 241 | [
"DDInter1842",
"DDInter661"
] | Trametinib | Erdafitinib | Trametinib is an orally bioavailable mitogen-activated extracellular signal-regulated kinase 1 (MEK1) and MEK2 inhibitor.[A258298,A258293] It was first approved by the FDA in May 2013 for the treatment of melanoma. It was later approved by Health Canada on July 18, 2013 and by the European Commission on June 30, 2014. ... | In early April of 2019, the US FDA approved Janssen Pharmaceutical Companies' brand name Balversa (erdafitinib) as the first-ever fibroblast growth factor receptor (FGFR) kinase inhibitor indicated for patients with locally advanced or metastatic urothelial carcinoma, with susceptible FGFR3 or FGFR2 genetic alterations... | Moderate | 1 | [
[
[
1556,
24,
241
]
],
[
[
1556,
24,
384
],
[
384,
24,
241
]
],
[
[
1556,
24,
913
],
[
913,
25,
241
]
],
[
[
1556,
63,
129
],
[
129,
... | [
[
[
"Trametinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Erdafitinib"
]
],
[
[
"Trametinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
[
... | Trametinib may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Erdafitinib
Trametinib may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide and Apal... |
DB00290 | DB00978 | 329 | 739 | [
"DDInter219",
"DDInter1084"
] | Bleomycin | Lomefloxacin | A complex of related glycopeptide antibiotics from <i>Streptomyces verticillus</i> consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin. | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Minor | 0 | [
[
[
329,
23,
739
]
],
[
[
329,
23,
945
],
[
945,
40,
739
]
],
[
[
329,
62,
1176
],
[
1176,
1,
739
]
],
[
[
329,
23,
1299
],
[
1299,
... | [
[
[
"Bleomycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lomefloxacin"
]
],
[
[
"Bleomycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sparfloxacin"
],
[
... | Bleomycin may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Lomefloxacin (Compound)
Bleomycin may cause a minor interaction that can limit clinical effects when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Lomefloxacin (Comp... |
DB00881 | DB09146 | 954 | 489 | [
"DDInter1554",
"DDInter978"
] | Quinapril | Iron sucrose | Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure.[L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta b... | Iron sucrose (sucroferric oxyhydroxide or iron saccharate) is used as a source of iron in patients with iron deficiency anemia with chronic kidney disease (CKD), including those who are undergoing dialysis (hemodialysis or peritoneal) and those who do not require dialysis. Due to less side effects than iron dextran, ir... | Moderate | 1 | [
[
[
954,
24,
489
]
],
[
[
954,
40,
1058
],
[
1058,
24,
489
]
],
[
[
954,
63,
542
],
[
542,
24,
489
]
],
[
[
954,
24,
1669
],
[
1669,
... | [
[
[
"Quinapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron sucrose"
]
],
[
[
"Quinapril",
"{u} (Compound) resembles {v} (Compound)",
"Moexipril"
],
[
"Moexipril",
"{u} may cause a moderate ... | Quinapril (Compound) resembles Moexipril (Compound) and Moexipril may cause a moderate interaction that could exacerbate diseases when taken with Iron sucrose
Quinapril may cause a moderate interaction that could exacerbate diseases when taken with Levothyroxine and Levothyroxine may cause a moderate interaction that c... |
DB00431 | DB01142 | 1,503 | 1,264 | [
"DDInter1072",
"DDInter593"
] | Lindane | Doxepin | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
1503,
24,
1264
]
],
[
[
1503,
63,
508
],
[
508,
24,
1264
]
],
[
[
1503,
24,
401
],
[
401,
24,
1264
]
],
[
[
1503,
24,
1405
],
[
1405,
... | [
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promazine"
],
[
"Proma... | Lindane may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine ma... |
DB01018 | DB09280 | 1,364 | 1,604 | [
"DDInter847",
"DDInter1101"
] | Guanfacine | Lumacaftor | Guanfacine, or BS 100-141,[A189838,A189841] is a selective alpha-A2 adrenergic receptor agonist initially indicated for the treatment of hypertension but is now indicated as an extended release tablet for the treatment of ADHD. Guanfacine was first described in the literature in 1974. Guanfacine was granted FDA approva... | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Major | 2 | [
[
[
1364,
25,
1604
]
],
[
[
1364,
63,
1061
],
[
1061,
24,
1604
]
],
[
[
1364,
24,
1069
],
[
1069,
24,
1604
]
],
[
[
1364,
24,
971
],
[
971... | [
[
[
"Guanfacine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lumacaftor"
]
],
[
[
"Guanfacine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
[
"Treprost... | Guanfacine may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Lumacaftor
Guanfacine may cause a moderate interaction that could exacerbate diseases when taken with Vandetanib and Va... |
DB00603 | DB06206 | 303 | 1,268 | [
"DDInter1137",
"DDInter1719"
] | Medroxyprogesterone acetate | Sugammadex | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery. Rocuronium bromide and vecuronium bromide are neuromuscular blocking medications that cause temporary paralysis and are especially useful for general ane... | Major | 2 | [
[
[
303,
25,
1268
]
],
[
[
303,
63,
1647
],
[
1647,
23,
279
],
[
279,
24,
1268
]
],
[
[
303,
24,
913
],
[
913,
63,
279
],
[
279,
24,
... | [
[
[
"Medroxyprogesterone acetate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sugammadex"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acarbose... | Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose may cause a minor interaction that can limit clinical effects when taken with Anisindione and Anisindione may cause a moderate interaction that could exacerbate diseases when taken with Suga... |
DB00333 | DB05679 | 576 | 1,683 | [
"DDInter1166",
"DDInter1907"
] | Methadone | Ustekinumab | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Moderate | 1 | [
[
[
576,
24,
1683
]
],
[
[
576,
24,
1362
],
[
1362,
63,
1683
]
],
[
[
576,
25,
1250
],
[
1250,
63,
1683
]
],
[
[
576,
25,
1053
],
[
1053,
... | [
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]
],
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[
... | Methadone may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab
Methadone may lead to a major life threatening interaction when taken with Pazopanib and Pazopanib may cause a moder... |
DB00635 | DB01162 | 1,573 | 195 | [
"DDInter1515",
"DDInter1767"
] | Prednisone | Terazosin | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Terazosin is a quinazoline derivative alpha-1-selective adrenergic blocking agent indicated for benign prostatic hyperplasia and hypertension[FDA Label]. Terazosin blocks adrenaline's action on alpha-1 adrenergic receptors, causing relaxation of smooth muscle in blood vessels and the prostate. | Moderate | 1 | [
[
[
1573,
24,
195
]
],
[
[
1573,
63,
1205
],
[
1205,
40,
195
]
],
[
[
1573,
6,
4973
],
[
4973,
45,
195
]
],
[
[
1573,
21,
28882
],
[
28882... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Terazosin"
]
],
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prazosin"
],
[
... | Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Prazosin and Prazosin (Compound) resembles Terazosin (Compound)
Prednisone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Terazosin (Compound)
Prednisone (Compound) causes Body temperature increased (Side Effect) and ... |
DB00307 | DB00530 | 1,101 | 1,195 | [
"DDInter202",
"DDInter667"
] | Bexarotene | Erlotinib | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | Moderate | 1 | [
[
[
1101,
24,
1195
]
],
[
[
1101,
24,
883
],
[
883,
40,
1195
]
],
[
[
1101,
6,
8374
],
[
8374,
45,
1195
]
],
[
[
1101,
21,
28759
],
[
2875... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Erlotinib"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Erlotinib (Compound)
Bexarotene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Erlotinib (Compound)
Bexarotene (Compound) causes Connective tissue disorder (Side Effect) ... |
DB00357 | DB08893 | 1,051 | 271 | [
"DDInter71",
"DDInter1229"
] | Aminoglutethimide | Mirabegron | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Mirabegron is a sympathomimetic beta-3 adrenergic receptor agonist used to relax the smooth muscle of the bladder in the treatment of urinary frequency and incontinence. It is unique amongst overactive bladder treatment options in that, unlike other treatments such as [solifenacin] and [darifenacin], it lacks significa... | Minor | 0 | [
[
[
1051,
23,
271
]
],
[
[
1051,
6,
8374
],
[
8374,
45,
271
]
],
[
[
1051,
21,
29232
],
[
29232,
60,
271
]
],
[
[
1051,
24,
129
],
[
129,
... | [
[
[
"Aminoglutethimide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mirabegron"
]
],
[
[
"Aminoglutethimide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} ... | Aminoglutethimide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Mirabegron (Compound)
Aminoglutethimide (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Mirabegron (Compound)
Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00218 | DB11113 | 1,176 | 657 | [
"DDInter1247",
"DDInter307"
] | Moxifloxacin | Castor oil | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of , which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic... | Moderate | 1 | [
[
[
1176,
24,
657
]
],
[
[
1176,
25,
927
],
[
927,
63,
657
]
],
[
[
1176,
25,
1491
],
[
1491,
24,
657
]
],
[
[
1176,
1,
739
],
[
739,
... | [
[
[
"Moxifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Castor oil"
]
],
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
],
[
"Encor... | Moxifloxacin may lead to a major life threatening interaction when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Castor oil
Moxifloxacin may lead to a major life threatening interaction when taken with Midostaurin and Midostaurin may cause a moder... |
DB04908 | DB08882 | 1,671 | 1,281 | [
"DDInter741",
"DDInter1070"
] | Flibanserin | Linagliptin | Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder... | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
1671,
24,
1281
]
],
[
[
1671,
24,
1320
],
[
1320,
63,
1281
]
],
[
[
1671,
24,
868
],
[
868,
24,
1281
]
],
[
[
1671,
63,
629
],
[
629,
... | [
[
[
"Flibanserin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Flibanserin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
],
[
... | Flibanserin may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elagolix may cause a moderate interaction that could exacerbate diseases when taken with Linagliptin
Flibanserin may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vemura... |
DB00026 | DB08826 | 1,184 | 1,292 | [
"DDInter94",
"DDInter489"
] | Anakinra | Deferiprone | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Major | 2 | [
[
[
1184,
25,
1292
]
],
[
[
1184,
23,
1193
],
[
1193,
63,
1292
]
],
[
[
1184,
24,
482
],
[
482,
25,
1292
]
],
[
[
1184,
24,
1619
],
[
1619... | [
[
[
"Anakinra",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deferiprone"
]
],
[
[
"Anakinra",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Zinc glucon... | Anakinra may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a moderate interaction that could exacerbate diseases when taken with Deferiprone
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine and Tio... |
DB08827 | DB09122 | 990 | 1,613 | [
"DDInter1085",
"DDInter1409"
] | Lomitapide | Peginterferon beta-1a | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Major | 2 | [
[
[
990,
25,
1613
]
],
[
[
990,
64,
600
],
[
600,
24,
1613
]
],
[
[
990,
25,
292
],
[
292,
24,
1613
]
],
[
[
990,
25,
351
],
[
351,
... | [
[
[
"Lomitapide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Lomitapide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fluconazole"
],
[
"Fluconazole",... | Lomitapide may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Lomitapide may lead to a major life threatening interaction when taken with Regorafenib and Regorafenib may cause ... |
DB00543 | DB00889 | 87 | 1,133 | [
"DDInter82",
"DDInter840"
] | Amoxapine | Granisetron | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Major | 2 | [
[
[
87,
25,
1133
]
],
[
[
87,
63,
19
],
[
19,
40,
1133
]
],
[
[
87,
24,
85
],
[
85,
1,
1133
]
],
[
[
87,
6,
17589
],
[
17589,
45,
... | [
[
[
"Amoxapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Granisetron"
]
],
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
[
"Hyoscyamin... | Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine (Compound) resembles Granisetron (Compound)
Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine (Compound) resembles Granisetron (Compound)
Am... |
DB00047 | DB01069 | 176 | 401 | [
"DDInter932",
"DDInter1533"
] | Insulin glargine | Promethazine | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
176,
24,
401
]
],
[
[
176,
24,
146
],
[
146,
24,
401
]
],
[
[
176,
24,
820
],
[
820,
63,
401
]
],
[
[
176,
24,
1247
],
[
1247,
2... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propiomazine"... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Propiomazine and Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Ali... |
DB00377 | DB01403 | 1,494 | 9 | [
"DDInter1382",
"DDInter1175"
] | Palonosetron | Methotrimeprazine | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Moderate | 1 | [
[
[
1494,
24,
9
]
],
[
[
1494,
24,
1178
],
[
1178,
40,
9
]
],
[
[
1494,
25,
1164
],
[
1164,
1,
9
]
],
[
[
1494,
25,
684
],
[
684,
40... | [
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrimeprazine"
]
],
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"... | Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Methotrimeprazine (Compound)
Palonosetron may lead to a major life threatening interaction when taken with Trimipramine and Trimipramine (Compound) resembles Methotrimepr... |
DB00352 | DB04855 | 482 | 540 | [
"DDInter1814",
"DDInter602"
] | Tioguanine | Dronedarone | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Moderate | 1 | [
[
[
482,
24,
540
]
],
[
[
482,
24,
33
],
[
33,
40,
540
]
],
[
[
482,
21,
28722
],
[
28722,
60,
540
]
],
[
[
482,
24,
896
],
[
896,
2... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronedarone"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiodarone"
],
[
... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Amiodarone and Amiodarone (Compound) resembles Dronedarone (Compound)
Tioguanine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Dronedarone (Compound)
Tioguanine may cause a moderate interaction that... |
DB00261 | DB00489 | 702 | 17 | [
"DDInter93",
"DDInter1704"
] | Anagrelide | Sotalol | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventric... | Major | 2 | [
[
[
702,
25,
17
]
],
[
[
702,
25,
347
],
[
347,
40,
17
]
],
[
[
702,
21,
28719
],
[
28719,
60,
17
]
],
[
[
702,
23,
417
],
[
417,
23... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sotalol"
]
],
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ibutilide"
],
[
"Ibutilide",
"{u} (Compo... | Anagrelide may lead to a major life threatening interaction when taken with Ibutilide and Ibutilide (Compound) resembles Sotalol (Compound)
Anagrelide (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Sotalol (Compound)
Anagrelide may cause a minor interaction that can limit clinical effects when... |
DB00500 | DB09030 | 24 | 840 | [
"DDInter1831",
"DDInter1945"
] | Tolmetin | Vorapaxar | A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin. | Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expr... | Major | 2 | [
[
[
24,
25,
840
]
],
[
[
24,
24,
885
],
[
885,
24,
840
]
],
[
[
24,
63,
1061
],
[
1061,
24,
840
]
],
[
[
24,
24,
738
],
[
738,
63,
... | [
[
[
"Tolmetin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vorapaxar"
]
],
[
[
"Tolmetin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
],
[
"Epoprostenol"... | Tolmetin may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Vorapaxar
Tolmetin may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Trepr... |
DB00982 | DB08870 | 1,517 | 850 | [
"DDInter991",
"DDInter228"
] | Isotretinoin | Brentuximab vedotin | Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.[Label] It was most widely marketed under the brand name Accutane, which has since been discontinued. Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
1517,
24,
850
]
],
[
[
1517,
63,
267
],
[
267,
24,
850
]
],
[
[
1517,
24,
1033
],
[
1033,
63,
850
]
],
[
[
1517,
25,
943
],
[
943,
... | [
[
[
"Isotretinoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Isotretinoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
... | Isotretinoin may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Isotretinoin may cause a moderate interaction that could exacerbate diseases when taken with Alpelisi... |
DB00188 | DB13007 | 168 | 1,060 | [
"DDInter222",
"DDInter642"
] | Bortezomib | Enfortumab vedotin | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Enfortumab vedotin is an antibody-drug conjugate used in the treatment of patients with advanced, treatment-resistant urothelial cancers. It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting chemotherapeutic agent, monomethyl auristatin E (MMAE), joined by a protea... | Moderate | 1 | [
[
[
168,
24,
1060
]
],
[
[
168,
25,
1604
],
[
1604,
23,
1060
]
],
[
[
168,
24,
590
],
[
590,
24,
1060
]
],
[
[
168,
63,
58
],
[
58,
... | [
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enfortumab vedotin"
]
],
[
[
"Bortezomib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lumacaftor"
],
[
"Lu... | Bortezomib may lead to a major life threatening interaction when taken with Lumacaftor and Lumacaftor may cause a minor interaction that can limit clinical effects when taken with Enfortumab vedotin
Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and Acetohexamid... |
DB00559 | DB11703 | 152 | 405 | [
"DDInter223",
"DDInter9"
] | Bosentan | Acalabrutinib | Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure. | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Moderate | 1 | [
[
[
152,
24,
405
]
],
[
[
152,
63,
1324
],
[
1324,
24,
405
]
],
[
[
152,
62,
1101
],
[
1101,
24,
405
]
],
[
[
152,
24,
951
],
[
951,
... | [
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troglitazone"
],
[
... | Bosentan may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Bosentan may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexar... |
DB00701 | DB11691 | 1,091 | 1,499 | [
"DDInter90",
"DDInter1258"
] | Amprenavir | Naldemedine | Amprenavir is a protease inhibitor used to treat HIV infection. | Naldemedine is an opioid receptor antagonist [FDA Label]. It is a modified form of to which a side chain has been added to increase molecular weight and polar surface area resulting in restricted transport across the blood brain barrier. Naldemedine was approved in 2017 in both the US and Japan for the treatment of Opi... | Moderate | 1 | [
[
[
1091,
24,
1499
]
],
[
[
1091,
63,
723
],
[
723,
24,
1499
]
],
[
[
1091,
25,
1670
],
[
1670,
24,
1499
]
],
[
[
1091,
25,
1406
],
[
1406... | [
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naldemedine"
]
],
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[
... | Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Naldemedine
Amprenavir may lead to a major life threatening interaction when taken with Eliglustat and Eliglustat may cause... |
DB00867 | DB01166 | 1,052 | 477 | [
"DDInter1606",
"DDInter379"
] | Ritodrine | Cilostazol | Adrenergic beta-agonist used to control premature labor. | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Moderate | 1 | [
[
[
1052,
24,
477
]
],
[
[
1052,
7,
3422
],
[
3422,
46,
477
]
],
[
[
1052,
63,
888
],
[
888,
24,
477
]
],
[
[
1052,
24,
1133
],
[
1133,
... | [
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
]
],
[
[
"Ritodrine",
"{u} (Compound) upregulates {v} (Gene)",
"SATB1"
],
[
"SATB1",
"{u} (Gene) is upregulated by {v} (Com... | Ritodrine (Compound) upregulates SATB1 (Gene) and SATB1 (Gene) is upregulated by Cilostazol (Compound)
Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Cilostazol
Ritodrine ma... |
DB00792 | DB11130 | 832 | 407 | [
"DDInter1878",
"DDInter1344"
] | Tripelennamine | Opium | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
832,
24,
407
]
],
[
[
832,
63,
558
],
[
558,
24,
407
]
],
[
[
832,
24,
1190
],
[
1190,
24,
407
]
],
[
[
832,
74,
662
],
[
662,
2... | [
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zolpidem"
],
[
... | Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Zolpidem and Zolpidem may cause a moderate interaction that could exacerbate diseases when taken with Opium
Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Ketamine and Ketamine ... |
DB00196 | DB00218 | 600 | 1,176 | [
"DDInter743",
"DDInter1247"
] | Fluconazole | Moxifloxacin | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Major | 2 | [
[
[
600,
25,
1176
]
],
[
[
600,
25,
945
],
[
945,
40,
1176
]
],
[
[
600,
24,
956
],
[
956,
40,
1176
]
],
[
[
600,
21,
28759
],
[
28759,
... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Moxifloxacin"
]
],
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sparfloxacin"
],
[
"Sparfloxacin",
... | Fluconazole may lead to a major life threatening interaction when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Moxifloxacin (Compound)
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Norfloxacin and Norfloxacin (Compound) resembles Moxifloxacin (Compound)
Flu... |
DB00574 | DB06822 | 121 | 802 | [
"DDInter717",
"DDInter1812"
] | Fenfluramine | Tinzaparin | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Tinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for h... | Moderate | 1 | [
[
[
121,
24,
802
]
],
[
[
121,
25,
222
],
[
222,
24,
802
]
],
[
[
121,
64,
758
],
[
758,
24,
802
]
],
[
[
121,
25,
1427
],
[
1427,
6... | [
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tinzaparin"
]
],
[
[
"Fenfluramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
],
[
"Sibut... | Fenfluramine may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Tinzaparin
Fenfluramine may lead to a major life threatening interaction when taken with Fluoxetine and Fluoxetine may cause a moderat... |
DB01088 | DB11703 | 714 | 405 | [
"DDInter908",
"DDInter9"
] | Iloprost | Acalabrutinib | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Major | 2 | [
[
[
714,
25,
405
]
],
[
[
714,
63,
383
],
[
383,
24,
405
]
],
[
[
714,
24,
643
],
[
643,
24,
405
]
],
[
[
714,
24,
738
],
[
738,
63,... | [
[
[
"Iloprost",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Iloprost",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentosan polysulfate"
],
[
"P... | Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Pentosan polysulfate and Pentosan polysulfate may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Iloprost may cause a moderate interaction that could exacerbate diseases when taken with De... |
DB00005 | DB14444 | 1,057 | 151 | [
"DDInter687",
"DDInter924"
] | Etanercept | Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immuno... | Moderate | 1 | [
[
[
1057,
24,
151
]
],
[
[
1057,
24,
66
],
[
66,
24,
151
]
],
[
[
1057,
25,
134
],
[
134,
24,
151
]
],
[
[
1057,
25,
994
],
[
994,
6... | [
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)"
]
],
[
[
"Etanercept",
"{u} may cause a moderate interaction that could e... | Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Etanercept may lead to a major life t... |
DB01100 | DB06603 | 1,568 | 39 | [
"DDInter1470",
"DDInter1387"
] | Pimozide | Panobinostat | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
1568,
25,
39
]
],
[
[
1568,
62,
112
],
[
112,
23,
39
]
],
[
[
1568,
63,
912
],
[
912,
24,
39
]
],
[
[
1568,
24,
272
],
[
272,
24... | [
[
[
"Pimozide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Pimozide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidazo... | Pimozide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Pimozide may cause a moderate interaction that could exacerbate diseases when taken with Interferon beta-1a an... |
DB00816 | DB01159 | 1,674 | 419 | [
"DDInter1346",
"DDInter854"
] | Orciprenaline | Halothane | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required... | Moderate | 1 | [
[
[
1674,
24,
419
]
],
[
[
1674,
24,
774
],
[
774,
63,
419
]
],
[
[
1674,
35,
1148
],
[
1148,
24,
419
]
],
[
[
1674,
24,
1264
],
[
1264,
... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Halothane"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Degarelix"
],
... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Degarelix and Degarelix may cause a moderate interaction that could exacerbate diseases when taken with Halothane
Orciprenaline (Compound) resembles Isoprenaline (Compound) and Orciprenaline may cause a moderate interaction th... |
DB00405 | DB00981 | 128 | 1,528 | [
"DDInter517",
"DDInter1462"
] | Dexbrompheniramine | Physostigmine | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | Moderate | 1 | [
[
[
128,
24,
1528
]
],
[
[
128,
24,
508
],
[
508,
24,
1528
]
],
[
[
128,
24,
1511
],
[
1511,
63,
1528
]
],
[
[
128,
63,
1386
],
[
1386,
... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Physostigmine"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promazin... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Physostigmine
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Mepe... |
DB09268 | DB11642 | 1,662 | 938 | [
"DDInter1464",
"DDInter1480"
] | Picosulfuric acid | Pitolisant | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Moderate | 1 | [
[
[
1662,
24,
938
]
],
[
[
1662,
63,
112
],
[
112,
23,
938
]
],
[
[
1662,
63,
600
],
[
600,
24,
938
]
],
[
[
1662,
64,
1181
],
[
1181,
... | [
[
[
"Picosulfuric acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitolisant"
]
],
[
[
"Picosulfuric acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole... | Picosulfuric acid may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pitolisant
Picosulfuric acid may cause a moderate interaction that could exacerbate diseases when taken with Flu... |
DB01240 | DB06237 | 885 | 438 | [
"DDInter657",
"DDInter141"
] | Epoprostenol | Avanafil | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Avanafil is a phosphodiesterase-5 (PDE5) inhibitor used in the treatment of erectile dysfunction. In comparison with other drugs of the same class, it shows greater selectivity for PDE5 over PDE6 than both [sildenafil] and [vardenafil] but less selectivity than [tadalafil], suggesting a relatively lower risk of visual ... | Moderate | 1 | [
[
[
885,
24,
438
]
],
[
[
885,
21,
29118
],
[
29118,
60,
438
]
],
[
[
885,
24,
549
],
[
549,
63,
438
]
],
[
[
885,
63,
1214
],
[
1214,
... | [
[
[
"Epoprostenol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Avanafil"
]
],
[
[
"Epoprostenol",
"{u} (Compound) causes {v} (Side Effect)",
"Tachycardia"
],
[
"Tachycardia",
"{u} (Side Effect) i... | Epoprostenol (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Avanafil (Compound)
Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin may cause a moderate interaction that could exacerbate diseases when taken ... |
DB01033 | DB01155 | 328 | 872 | [
"DDInter1156",
"DDInter813"
] | Mercaptopurine | Gemifloxacin | An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Minor | 0 | [
[
[
328,
23,
872
]
],
[
[
328,
62,
739
],
[
739,
1,
872
]
],
[
[
328,
23,
956
],
[
956,
1,
872
]
],
[
[
328,
23,
945
],
[
945,
40,
... | [
[
[
"Mercaptopurine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Gemifloxacin"
]
],
[
[
"Mercaptopurine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lomefloxacin"
],
... | Mercaptopurine may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gemifloxacin (Compound)
Mercaptopurine may cause a minor interaction that can limit clinical effects when taken with Norfloxacin and Norfloxacin (Compound) resembles Gemifloxac... |
DB00704 | DB01320 | 267 | 651 | [
"DDInter1263",
"DDInter783"
] | Naltrexone | Fosphenytoin | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Moderate | 1 | [
[
[
267,
24,
651
]
],
[
[
267,
63,
362
],
[
362,
1,
651
]
],
[
[
267,
24,
998
],
[
998,
1,
651
]
],
[
[
267,
21,
29360
],
[
29360,
6... | [
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
[
... | Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Compound)
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutazone and Phenylbutazone (Compound) resembles Fosphenytoin (... |
DB00745 | DB06605 | 307 | 1,409 | [
"DDInter1236",
"DDInter108"
] | Modafinil | Apixaban | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Minor | 0 | [
[
[
307,
23,
1409
]
],
[
[
307,
6,
10215
],
[
10215,
45,
1409
]
],
[
[
307,
21,
29061
],
[
29061,
60,
1409
]
],
[
[
307,
24,
1670
],
[
167... | [
[
[
"Modafinil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Apixaban"
]
],
[
[
"Modafinil",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compound)",
... | Modafinil (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Apixaban (Compound)
Modafinil (Compound) causes Gamma-glutamyltransferase increased (Side Effect) and Gamma-glutamyltransferase increased (Side Effect) is caused by Apixaban (Compound)
Modafinil may cause a moderate interaction that could exacerba... |
DB01344 | DB01377 | 1,231 | 1,283 | [
"DDInter1830",
"DDInter1119"
] | Tolevamer | Magnesium oxide | Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines. It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among others, H... | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Major | 2 | [
[
[
1231,
25,
1283
]
],
[
[
1231,
63,
684
],
[
684,
23,
1283
]
],
[
[
1231,
24,
1482
],
[
1482,
62,
1283
]
],
[
[
1231,
25,
286
],
[
286,
... | [
[
[
"Tolevamer",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Magnesium oxide"
]
],
[
[
"Tolevamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thioridazine"
],
[
"Thior... | Tolevamer may cause a moderate interaction that could exacerbate diseases when taken with Thioridazine and Thioridazine may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
Tolevamer may cause a moderate interaction that could exacerbate diseases when taken with Digitoxin and Di... |
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