drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00242 | DB12130 | 1,064 | 1,017 | [
"DDInter392",
"DDInter1094"
] | Cladribine | Lorlatinib | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
1064,
24,
1017
]
],
[
[
1064,
24,
1612
],
[
1612,
23,
1017
]
],
[
[
1064,
25,
1101
],
[
1101,
23,
1017
]
],
[
[
1064,
25,
175
],
[
175... | [
[
[
"Cladribine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Cladribine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
],
[
... | Cladribine may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir and Fostemsavir may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Cladribine may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause ... |
DB00224 | DB08865 | 215 | 1,593 | [
"DDInter917",
"DDInter448"
] | Indinavir | Crizotinib | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem] | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Major | 2 | [
[
[
215,
25,
1593
]
],
[
[
215,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
215,
18,
16641
],
[
16641,
57,
1593
]
],
[
[
215,
21,
28771
],
[
2877... | [
[
[
"Indinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
]
],
[
[
"Indinavir",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Crizotini... | Indinavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Indinavir (Compound) downregulates LYPLA1 (Gene) and LYPLA1 (Gene) is downregulated by Crizotinib (Compound)
Indinavir (Compound) causes Respiratory failure (Side Effect) and Respiratory failure (Side Effect) is caused by Crizo... |
DB00047 | DB00612 | 176 | 1,121 | [
"DDInter932",
"DDInter216"
] | Insulin glargine | Bisoprolol | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | Moderate | 1 | [
[
[
176,
24,
1121
]
],
[
[
176,
24,
819
],
[
819,
40,
1121
]
],
[
[
176,
24,
417
],
[
417,
23,
1121
]
],
[
[
176,
24,
1479
],
[
1479,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisoprolol"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acebutolol"
... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Acebutolol and Acebutolol (Compound) resembles Bisoprolol (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Sucralfate and Sucralfate may cause a minor interaction t... |
DB09075 | DB10344 | 498 | 992 | [
"DDInter621",
"DDInter818"
] | Edoxaban | Ginger | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Ginger allergenic extract is used in allergenic testing. | Moderate | 1 | [
[
[
498,
24,
992
]
],
[
[
498,
64,
1578
],
[
1578,
24,
992
]
],
[
[
498,
25,
1421
],
[
1421,
63,
992
]
],
[
[
498,
64,
1578
],
[
1578,
... | [
[
[
"Edoxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginger"
]
],
[
[
"Edoxaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lepirudin"
],
[
"Lepirudin",
"... | Edoxaban may lead to a major life threatening interaction when taken with Lepirudin and Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Ginger
Edoxaban may lead to a major life threatening interaction when taken with Betrixaban and Betrixaban may cause a moderate interaction th... |
DB00231 | DB00295 | 1,174 | 475 | [
"DDInter1761",
"DDInter1244"
] | Temazepam | Morphine | Temazepam, like many other similar and related benzodiazepines, acts as a gamma-aminobutyric acid (GABA) modulator and is capable of eliciting a variety of actions including sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action [A175207, A175210, F3718, F3721]. Although the chem... | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Major | 2 | [
[
[
1174,
25,
475
]
],
[
[
1174,
6,
3486
],
[
3486,
45,
475
]
],
[
[
1174,
21,
28784
],
[
28784,
60,
475
]
],
[
[
1174,
24,
820
],
[
820,
... | [
[
[
"Temazepam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Morphine"
]
],
[
[
"Temazepam",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",
"Morphine"
... | Temazepam (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Morphine (Compound)
Temazepam (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Morphine (Compound)
Temazepam may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine ... |
DB00899 | DB01233 | 411 | 1,311 | [
"DDInter1579",
"DDInter1197"
] | Remifentanil | Metoclopramide | Remifentanil (marketed by Abbott as Ultiva) is a potent ultra short-acting synthetic opioid given to patients during surgery for pain relief and adjunctive to an anaesthetic. Remifentanil is a specific mu-type-opioid receptor agonist which means it reduces sympathetic nervous system tone, and causes respiratory depress... | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Moderate | 1 | [
[
[
411,
24,
1311
]
],
[
[
411,
21,
28691
],
[
28691,
60,
1311
]
],
[
[
411,
24,
1383
],
[
1383,
63,
1311
]
],
[
[
411,
63,
662
],
[
662,
... | [
[
[
"Remifentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
]
],
[
[
"Remifentanil",
"{u} (Compound) causes {v} (Side Effect)",
"Somnolence"
],
[
"Somnolence",
"{u} (Side Effec... | Remifentanil (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Metoclopramide (Compound)
Remifentanil may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate and Sodium sulfate may cause a moderate interaction that could exacerbate diseases when ... |
DB00005 | DB06589 | 1,057 | 1,250 | [
"DDInter687",
"DDInter1400"
] | Etanercept | Pazopanib | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Major | 2 | [
[
[
1057,
25,
1250
]
],
[
[
1057,
24,
112
],
[
112,
23,
1250
]
],
[
[
1057,
24,
651
],
[
651,
24,
1250
]
],
[
[
1057,
25,
1419
],
[
1419,
... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pazopanib"
]
],
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
"Metronid... | Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pazopanib
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Fosphenytoin and F... |
DB00374 | DB00945 | 1,061 | 1,479 | [
"DDInter1852",
"DDInter20"
] | Treprostinil | Acetylsalicylic acid | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Moderate | 1 | [
[
[
1061,
24,
1479
]
],
[
[
1061,
24,
1338
],
[
1338,
24,
1479
]
],
[
[
1061,
6,
6017
],
[
6017,
45,
1479
]
],
[
[
1061,
7,
7720
],
[
7720... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
]
],
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meclofenamic ... | Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Meclofenamic acid and Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid
Treprostinil (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Acetylsalicy... |
DB11921 | DB14730 | 1,019 | 1,412 | [
"DDInter492",
"DDInter264"
] | Deflazacort | Calaspargase pegol | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
1019,
24,
1412
]
],
[
[
1019,
63,
1439
],
[
1439,
24,
1412
]
],
[
[
1019,
24,
159
],
[
159,
24,
1412
]
],
[
[
1019,
64,
593
],
[
593,
... | [
[
[
"Deflazacort",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Deflazacort",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ipilimumab"
]... | Deflazacort may cause a moderate interaction that could exacerbate diseases when taken with Ipilimumab and Ipilimumab may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Deflazacort may cause a moderate interaction that could exacerbate diseases when taken with Larotrectin... |
DB00497 | DB01575 | 828 | 1,054 | [
"DDInter1366",
"DDInter1005"
] | Oxycodone | Kaolin | Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.[Label] The f... | Kaolin is a layered silicate mineral. Kaolin is used in ceramics, medicine, coated paper, as a food additive, in toothpaste, as a light diffusing material in white incandescent light bulbs, and in cosmetics. Until the early 1990s it was the active substance of anti-diarrhoea medicine Kaopectate. | Moderate | 1 | [
[
[
828,
24,
1054
]
],
[
[
828,
24,
407
],
[
407,
63,
1054
]
],
[
[
828,
24,
85
],
[
85,
24,
1054
]
],
[
[
828,
64,
475
],
[
475,
24... | [
[
[
"Oxycodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Kaolin"
]
],
[
[
"Oxycodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
],
[
"Opium"... | Oxycodone may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause a moderate interaction that could exacerbate diseases when taken with Kaolin
Oxycodone may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine may cause a mod... |
DB00420 | DB00738 | 508 | 485 | [
"DDInter1532",
"DDInter1420"
] | Promazine | Pentamidine | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Moderate | 1 | [
[
[
508,
24,
485
]
],
[
[
508,
6,
8374
],
[
8374,
45,
485
]
],
[
[
508,
7,
7669
],
[
7669,
46,
485
]
],
[
[
508,
7,
8559
],
[
8559,
... | [
[
[
"Promazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentamidine"
]
],
[
[
"Promazine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Promazine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Pentamidine (Compound)
Promazine (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Pentamidine (Compound)
Promazine (Compound) upregulates HMGCR (Gene) and HMGCR (Gene) is downregulated by Pentamidine (Compound)
Promazine (Compo... |
DB00220 | DB01611 | 798 | 1,487 | [
"DDInter1276",
"DDInter893"
] | Nelfinavir | Hydroxychloroquine | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Moderate | 1 | [
[
[
798,
24,
1487
]
],
[
[
798,
6,
12523
],
[
12523,
45,
1487
]
],
[
[
798,
7,
2216
],
[
2216,
46,
1487
]
],
[
[
798,
21,
28658
],
[
28658... | [
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Nelfinavir",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Com... | Nelfinavir (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Hydroxychloroquine (Compound)
Nelfinavir (Compound) upregulates PAK1 (Gene) and PAK1 (Gene) is upregulated by Hydroxychloroquine (Compound)
Nelfinavir (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Hydroxychloroqui... |
DB00631 | DB08930 | 372 | 1,459 | [
"DDInter405",
"DDInter582"
] | Clofarabine | Dolutegravir | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Dolutegravir is an HIV-1 integrase inhibitor that blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI). The effect of this drug has no homology in human host cells, which gives it excellent tolerability and minimal toxicity. Dolutegravir was developed by ViiV Healthcare and ... | Moderate | 1 | [
[
[
372,
24,
1459
]
],
[
[
372,
21,
30631
],
[
30631,
60,
1459
]
],
[
[
372,
63,
1419
],
[
1419,
23,
1459
]
],
[
[
372,
24,
478
],
[
478,
... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dolutegravir"
]
],
[
[
"Clofarabine",
"{u} (Compound) causes {v} (Side Effect)",
"Rash generalised"
],
[
"Rash generalised",
"{u} (Si... | Clofarabine (Compound) causes Rash generalised (Side Effect) and Rash generalised (Side Effect) is caused by Dolutegravir (Compound)
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a minor interaction that can limit clinical effects when taken ... |
DB00047 | DB01364 | 176 | 22 | [
"DDInter932",
"DDInter650"
] | Insulin glargine | Ephedrine | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Moderate | 1 | [
[
[
176,
24,
22
]
],
[
[
176,
24,
1529
],
[
1529,
63,
22
]
],
[
[
176,
24,
280
],
[
280,
1,
22
]
],
[
[
176,
24,
1220
],
[
1220,
23,... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ephedrine"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metamfetamine"
... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Metamfetamine and Metamfetamine may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Meph... |
DB00076 | DB01100 | 1,352 | 1,568 | [
"DDInter555",
"DDInter1470"
] | Digoxin Immune Fab (Ovine) | Pimozide | Digoxin Immune Fab is a sheep antibody (26-10) FAB fragment from sheep immunized with the digoxin derivative Digoxindicarboxymethylamine. It is used as an antidote for overdose of digoxin. | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Major | 2 | [
[
[
1352,
25,
1568
]
],
[
[
1352,
25,
57
],
[
57,
64,
1568
]
],
[
[
1352,
24,
607
],
[
607,
6,
5289
],
[
5289,
45,
1568
]
],
[
[
1352,
... | [
[
[
"Digoxin Immune Fab (Ovine)",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pimozide"
]
],
[
[
"Digoxin Immune Fab (Ovine)",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
... | Digoxin Immune Fab (Ovine) may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may lead to a major life threatening interaction when taken with Pimozide
Digoxin Immune Fab (Ovine) may cause a moderate interaction that could exacerbate diseases when taken with Amisulpri... |
DB00549 | DB04938 | 522 | 1,423 | [
"DDInter1955",
"DDInter1353"
] | Zafirlukast | Ospemifene | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Ospemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. FDA approved on February 26, 2013. | Moderate | 1 | [
[
[
522,
24,
1423
]
],
[
[
522,
6,
6017
],
[
6017,
45,
1423
]
],
[
[
522,
24,
129
],
[
129,
63,
1423
]
],
[
[
522,
24,
478
],
[
478,
... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ospemifene"
]
],
[
[
"Zafirlukast",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)... | Zafirlukast (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Ospemifene (Compound)
Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Ospemifene
Zafirlukast ... |
DB00209 | DB01075 | 352 | 1,376 | [
"DDInter1886",
"DDInter569"
] | Trospium | Diphenhydramine | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
352,
24,
1376
]
],
[
[
352,
24,
128
],
[
128,
24,
1376
]
],
[
[
352,
40,
11286
],
[
11286,
1,
1376
]
],
[
[
352,
35,
357
],
[
357,
... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexbrompheniramine"
],... | Trospium may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine and Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Trospium (Compound) resembles Diphenylpyraline (Compound) and Diphenylpyraline (Compound) res... |
DB00836 | DB01166 | 543 | 477 | [
"DDInter1088",
"DDInter379"
] | Loperamide | Cilostazol | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Moderate | 1 | [
[
[
543,
24,
477
]
],
[
[
543,
6,
8374
],
[
8374,
45,
477
]
],
[
[
543,
18,
4303
],
[
4303,
57,
477
]
],
[
[
543,
21,
29340
],
[
29340,
... | [
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
]
],
[
[
"Loperamide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Loperamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cilostazol (Compound)
Loperamide (Compound) downregulates CLTB (Gene) and CLTB (Gene) is downregulated by Cilostazol (Compound)
Loperamide (Compound) causes Stevens-Johnson syndrome (Side Effect) and Stevens-Johnson syndrome (Side Effect) is caused... |
DB04908 | DB05812 | 1,671 | 1,374 | [
"DDInter741",
"DDInter8"
] | Flibanserin | Abiraterone | Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder... | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
1671,
24,
1374
]
],
[
[
1671,
23,
1135
],
[
1135,
62,
1374
]
],
[
[
1671,
25,
760
],
[
760,
62,
1374
]
],
[
[
1671,
24,
1409
],
[
1409... | [
[
[
"Flibanserin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Flibanserin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Flibanserin may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Abiraterone
Flibanserin may lead to a major life threatening interaction when taken with Cobicistat and Cobicistat may cause a m... |
DB01156 | DB09472 | 593 | 1,383 | [
"DDInter252",
"DDInter1693"
] | Bupropion | Sodium sulfate | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
593,
24,
1383
]
],
[
[
593,
63,
1252
],
[
1252,
23,
1383
]
],
[
[
593,
64,
678
],
[
678,
24,
1383
]
],
[
[
593,
25,
643
],
[
643,
... | [
[
[
"Bupropion",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Bupropion",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digoxin"
],
[
... | Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin may cause a minor interaction that can limit clinical effects when taken with Sodium sulfate
Bupropion may lead to a major life threatening interaction when taken with Oxamniquine and Oxamniquine may cause a mo... |
DB00289 | DB08880 | 847 | 1,510 | [
"DDInter132",
"DDInter1771"
] | Atomoxetine | Teriflunomide | Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD). Also known as the marketed product Strattera, atomoxetine is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve develop... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
847,
25,
1510
]
],
[
[
847,
24,
129
],
[
129,
63,
1510
]
],
[
[
847,
24,
752
],
[
752,
24,
1510
]
],
[
[
847,
23,
112
],
[
112,
... | [
[
[
"Atomoxetine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Atomoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
[
"Enz... | Atomoxetine may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide
Atomoxetine may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine a... |
DB00047 | DB01241 | 176 | 1,206 | [
"DDInter932",
"DDInter812"
] | Insulin glargine | Gemfibrozil | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Gemfibrozil is a fibric acid agent, similar to [clofibrate], used to treat Type IIb, IV, and V hyperlipidemias.[A185777,L8525] Gemfibrozil is not a first line treatment and is prescribed to patients who have not responded adequately to weight loss, diet, exercise, and other medications. Gemfibrozil was granted FDA appr... | Moderate | 1 | [
[
[
176,
24,
1206
]
],
[
[
176,
24,
1476
],
[
1476,
62,
1206
]
],
[
[
176,
24,
590
],
[
590,
24,
1206
]
],
[
[
176,
24,
1040
],
[
1040,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gemfibrozil"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a minor interaction that can limit clinical effects when taken with Gemfibrozil
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Acetohexam... |
DB00975 | DB06700 | 1,317 | 643 | [
"DDInter573",
"DDInter511"
] | Dipyridamole | Desvenlafaxine | A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752) | Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of ad... | Moderate | 1 | [
[
[
1317,
24,
643
]
],
[
[
1317,
63,
1100
],
[
1100,
1,
643
]
],
[
[
1317,
21,
28641
],
[
28641,
60,
643
]
],
[
[
1317,
25,
292
],
[
292,
... | [
[
[
"Dipyridamole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desvenlafaxine"
]
],
[
[
"Dipyridamole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venlafaxine"
],... | Dipyridamole may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine (Compound) resembles Desvenlafaxine (Compound)
Dipyridamole (Compound) causes Hot flush (Side Effect) and Hot flush (Side Effect) is caused by Desvenlafaxine (Compound)
Dipyridamole may lead to a maj... |
DB01162 | DB11827 | 195 | 433 | [
"DDInter1767",
"DDInter669"
] | Terazosin | Ertugliflozin | Terazosin is a quinazoline derivative alpha-1-selective adrenergic blocking agent indicated for benign prostatic hyperplasia and hypertension[FDA Label]. Terazosin blocks adrenaline's action on alpha-1 adrenergic receptors, causing relaxation of smooth muscle in blood vessels and the prostate. | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
195,
24,
433
]
],
[
[
195,
63,
251
],
[
251,
24,
433
]
],
[
[
195,
1,
472
],
[
472,
24,
433
]
],
[
[
195,
24,
820
],
[
820,
24,
... | [
[
[
"Terazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Terazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betamethasone"
],
... | Terazosin may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Terazosin (Compound) resembles Alfuzosin (Compound) and Alfuzosin may cause a moderate interaction that ... |
DB00496 | DB00572 | 194 | 85 | [
"DDInter480",
"DDInter136"
] | Darifenacin | Atropine | Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence. Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it should not be used in people with urinary retention. It is unknown if M3 receptor ... | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Moderate | 1 | [
[
[
194,
24,
85
]
],
[
[
194,
63,
19
],
[
19,
24,
85
]
],
[
[
194,
6,
4304
],
[
4304,
45,
85
]
],
[
[
194,
54,
19228
],
[
19228,
15,... | [
[
[
"Darifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atropine"
]
],
[
[
"Darifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
[
... | Darifenacin may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Atropine
Darifenacin (Compound) binds CHRM2 (Gene) and CHRM2 (Gene) is bound by Atropine (Compound)
Darifenacin (Compoun... |
DB01220 | DB11828 | 1,088 | 1,406 | [
"DDInter1593",
"DDInter1281"
] | Rifaximin | Neratinib | Rifaximin is a semisynthetic, rifamycin-based non-systemic antibiotic, meaning that the drug will not pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics. It has multiple indications and is used in treatment of traveller's diarrhea caused by E. coli; reduc... | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Moderate | 1 | [
[
[
1088,
24,
1406
]
],
[
[
1088,
24,
1510
],
[
1510,
24,
1406
]
],
[
[
1088,
24,
971
],
[
971,
63,
1406
]
],
[
[
1088,
24,
1155
],
[
1155... | [
[
[
"Rifaximin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Neratinib"
]
],
[
[
"Rifaximin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Teriflunomide"
],
[
... | Rifaximin may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide and Teriflunomide may cause a moderate interaction that could exacerbate diseases when taken with Neratinib
Rifaximin may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib and G... |
DB00281 | DB08880 | 608 | 1,510 | [
"DDInter1066",
"DDInter1771"
] | Lidocaine | Teriflunomide | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anest... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Minor | 0 | [
[
[
608,
23,
1510
]
],
[
[
608,
23,
129
],
[
129,
63,
1510
]
],
[
[
608,
23,
697
],
[
697,
24,
1510
]
],
[
[
608,
24,
1580
],
[
1580,
... | [
[
[
"Lidocaine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Teriflunomide"
]
],
[
[
"Lidocaine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Enzalutamide"
],
[
... | Lidocaine may cause a minor interaction that can limit clinical effects when taken with Enzalutamide and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide
Lidocaine may cause a minor interaction that can limit clinical effects when taken with Phenobarbital and Ph... |
DB00620 | DB01136 | 175 | 772 | [
"DDInter1855",
"DDInter305"
] | Triamcinolone | Carvedilol | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Moderate | 1 | [
[
[
175,
24,
772
]
],
[
[
175,
6,
8374
],
[
8374,
45,
772
]
],
[
[
175,
21,
28997
],
[
28997,
60,
772
]
],
[
[
175,
23,
1283
],
[
1283,
... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carvedilol"
]
],
[
[
"Triamcinolone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compo... | Triamcinolone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Carvedilol (Compound)
Triamcinolone (Compound) causes Ill-defined disorder (Side Effect) and Ill-defined disorder (Side Effect) is caused by Carvedilol (Compound)
Triamcinolone may cause a minor interaction that can limit clinical effects when t... |
DB00745 | DB01142 | 307 | 1,264 | [
"DDInter1236",
"DDInter593"
] | Modafinil | Doxepin | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
307,
24,
1264
]
],
[
[
307,
1,
1335
],
[
1335,
24,
1264
]
],
[
[
307,
1,
11305
],
[
11305,
40,
1264
]
],
[
[
307,
1,
11244
],
[
11244,... | [
[
[
"Modafinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Modafinil",
"{u} (Compound) resembles {v} (Compound)",
"Oxcarbazepine"
],
[
"Oxcarbazepine",
"{u} may cause a modera... | Modafinil (Compound) resembles Oxcarbazepine (Compound) and Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Modafinil (Compound) resembles Phenindione (Compound) and Phenindione (Compound) resembles Doxepin (Compound)
Modafinil (Compound) resembles Pheniramine (Comp... |
DB00988 | DB01276 | 817 | 123 | [
"DDInter584",
"DDInter706"
] | Dopamine | Exenatide | One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action. | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Moderate | 1 | [
[
[
817,
24,
123
]
],
[
[
817,
40,
532
],
[
532,
24,
123
]
],
[
[
817,
24,
820
],
[
820,
24,
123
]
],
[
[
817,
63,
1685
],
[
1685,
2... | [
[
[
"Dopamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
]
],
[
[
"Dopamine",
"{u} (Compound) resembles {v} (Compound)",
"Dobutamine"
],
[
"Dobutamine",
"{u} may cause a moderate int... | Dopamine (Compound) resembles Dobutamine (Compound) and Dobutamine may cause a moderate interaction that could exacerbate diseases when taken with Exenatide
Dopamine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a moderate interaction that could ex... |
DB00206 | DB01285 | 1,245 | 708 | [
"DDInter1582",
"DDInter445"
] | Reserpine | Corticotropin | An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a rese... | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Moderate | 1 | [
[
[
1245,
24,
708
]
],
[
[
1245,
24,
1148
],
[
1148,
23,
708
]
],
[
[
1245,
24,
245
],
[
245,
24,
708
]
],
[
[
1245,
24,
1450
],
[
1450,
... | [
[
[
"Reserpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
]
],
[
[
"Reserpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
[... | Reserpine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a minor interaction that can limit clinical effects when taken with Corticotropin
Reserpine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Gl... |
DB01177 | DB01599 | 77 | 1,232 | [
"DDInter904",
"DDInter1523"
] | Idarubicin | Probucol | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993). | Moderate | 1 | [
[
[
77,
24,
1232
]
],
[
[
77,
62,
112
],
[
112,
23,
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]
],
[
[
77,
63,
1555
],
[
1555,
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]
],
[
[
77,
24,
927
],
[
927,
63... | [
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Probucol"
]
],
[
[
"Idarubicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Idarubicin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Probucol
Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxali... |
DB00065 | DB00631 | 581 | 372 | [
"DDInter923",
"DDInter405"
] | Infliximab | Clofarabine | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Major | 2 | [
[
[
581,
25,
372
]
],
[
[
581,
25,
1426
],
[
1426,
40,
372
]
],
[
[
581,
25,
1064
],
[
1064,
25,
372
]
],
[
[
581,
25,
329
],
[
329,
... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clofarabine"
]
],
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Azacitidine"
],
[
"Azacitidine",
"{u... | Infliximab may lead to a major life threatening interaction when taken with Azacitidine and Azacitidine (Compound) resembles Clofarabine (Compound)
Infliximab may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Clofa... |
DB05239 | DB09048 | 866 | 555 | [
"DDInter425",
"DDInter1284"
] | Cobimetinib | Netupitant | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Netupitant is an antiemitic drug approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy. Netupitant is a neurokinin 1 receptor antagonist. The combination drug i... | Major | 2 | [
[
[
866,
25,
555
]
],
[
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63,
1101
],
[
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23,
555
]
],
[
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866,
25,
283
],
[
283,
62,
555
]
],
[
[
866,
63,
1324
],
[
1324,
... | [
[
[
"Cobimetinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Netupitant"
]
],
[
[
"Cobimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
"Bexarote... | Cobimetinib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Netupitant
Cobimetinib may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause ... |
DB00294 | DB12500 | 1,336 | 283 | [
"DDInter701",
"DDInter714"
] | Etonogestrel | Fedratinib | Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel. The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001. | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
1336,
24,
283
]
],
[
[
1336,
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761
],
[
761,
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283
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[
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600
],
[
600,
24,
283
]
],
[
[
1336,
25,
1101
],
[
1101,
... | [
[
[
"Etonogestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Etonogestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
],
... | Etonogestrel may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin and Saxagliptin may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib
Etonogestrel may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and... |
DB01015 | DB06595 | 1,247 | 1,491 | [
"DDInter1724",
"DDInter1214"
] | Sulfamethoxazole | Midostaurin | Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps i... | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Minor | 0 | [
[
[
1247,
23,
1491
]
],
[
[
1247,
62,
112
],
[
112,
23,
1491
]
],
[
[
1247,
62,
888
],
[
888,
24,
1491
]
],
[
[
1247,
24,
1017
],
[
1017,
... | [
[
[
"Sulfamethoxazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Midostaurin"
]
],
[
[
"Sulfamethoxazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
... | Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Midostaurin
Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Tamoxife... |
DB00552 | DB08908 | 1,238 | 713 | [
"DDInter1425",
"DDInter564"
] | Pentostatin | Dimethyl fumarate | A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Moderate | 1 | [
[
[
1238,
24,
713
]
],
[
[
1238,
1,
1083
],
[
1083,
24,
713
]
],
[
[
1238,
24,
4
],
[
4,
24,
713
]
],
[
[
1238,
24,
270
],
[
270,
63... | [
[
[
"Pentostatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Pentostatin",
"{u} (Compound) resembles {v} (Compound)",
"Trifluridine"
],
[
"Trifluridine",
"{u} may ca... | Pentostatin (Compound) resembles Trifluridine (Compound) and Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Pentostatin may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate ... |
DB00348 | DB04868 | 254 | 478 | [
"DDInter1300",
"DDInter1293"
] | Nitisinone | Nilotinib | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Moderate | 1 | [
[
[
254,
24,
478
]
],
[
[
254,
21,
28762
],
[
28762,
60,
478
]
],
[
[
254,
24,
1247
],
[
1247,
23,
478
]
],
[
[
254,
23,
307
],
[
307,
... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]
],
[
[
"Nitisinone",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is caused ... | Nitisinone (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Nilotinib (Compound)
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with ... |
DB05679 | DB11988 | 1,683 | 270 | [
"DDInter1907",
"DDInter1321"
] | Ustekinumab | Ocrelizumab | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
1683,
24,
270
]
],
[
[
1683,
23,
1193
],
[
1193,
23,
270
]
],
[
[
1683,
62,
1461
],
[
1461,
23,
270
]
],
[
[
1683,
24,
1060
],
[
1060,... | [
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Ustekinumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
... | Ustekinumab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Ocrelizumab
Ustekinumab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vi... |
DB00405 | DB11732 | 128 | 1,097 | [
"DDInter517",
"DDInter1027"
] | Dexbrompheniramine | Lasmiditan | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Lasmiditan is an oral medication used in the termination of migraine headaches that was first approved for use in the United States in October 2019.[L9338,L9356] It was also approved by the European Commission on August 17, 2022. Traditionally, the triptan class of anti-migraine medications (e.g. [sumatriptan]) have se... | Moderate | 1 | [
[
[
128,
24,
1097
]
],
[
[
128,
63,
701
],
[
701,
24,
1097
]
],
[
[
128,
24,
1614
],
[
1614,
24,
1097
]
],
[
[
128,
74,
1594
],
[
1594,
... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lasmiditan"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Lasmiditan
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Nabil... |
DB01166 | DB15035 | 477 | 503 | [
"DDInter379",
"DDInter1959"
] | Cilostazol | Zanubrutinib | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Major | 2 | [
[
[
477,
25,
503
]
],
[
[
477,
25,
982
],
[
982,
24,
503
]
],
[
[
477,
63,
222
],
[
222,
24,
503
]
],
[
[
477,
24,
951
],
[
951,
24,... | [
[
[
"Cilostazol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Cilostazol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
],
[
"Ivosidenib",
"{u}... | Cilostazol may lead to a major life threatening interaction when taken with Ivosidenib and Ivosidenib may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may ca... |
DB06636 | DB09074 | 1,623 | 1,362 | [
"DDInter980",
"DDInter1327"
] | Isavuconazonium | Olaparib | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Major | 2 | [
[
[
1623,
25,
1362
]
],
[
[
1623,
63,
896
],
[
896,
24,
1362
]
],
[
[
1623,
25,
1478
],
[
1478,
24,
1362
]
],
[
[
1623,
24,
1619
],
[
1619... | [
[
[
"Isavuconazonium",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Olaparib"
]
],
[
[
"Isavuconazonium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
],
[
"Eto... | Isavuconazonium may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Isavuconazonium may lead to a major life threatening interaction when taken with Ivacaftor and Ivacaftor may ca... |
DB10343 | DB11569 | 962 | 1,093 | [
"DDInter160",
"DDInter1003"
] | Bacillus calmette-guerin substrain tice live antigen | Ixekizumab | Bacillus calmette-guerin substrain tice live antigen is a vaccine containing attenuated live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of *Mycobacterium bovis* for percutaneous use. It is administered to prevent the development of tuberculosis. | Ixekizumab is a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody (mAb) against interleukin-17A (IL-17A) and prevents it from interacting with the IL-17A receptor. As IL-17A is a pro-inflammatory cytokine involved in inflammation and immune responses, blocking its effect is beneficial for use in inflamma... | Major | 2 | [
[
[
962,
25,
1093
]
],
[
[
962,
64,
134
],
[
134,
24,
1093
]
],
[
[
962,
25,
270
],
[
270,
63,
1093
]
],
[
[
962,
64,
1057
],
[
1057,
... | [
[
[
"Bacillus calmette-guerin substrain tice live antigen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ixekizumab"
]
],
[
[
"Bacillus calmette-guerin substrain tice live antigen",
"{u} may lead to a major life threatening interaction wh... | Bacillus calmette-guerin substrain tice live antigen may lead to a major life threatening interaction when taken with Vinorelbine and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Ixekizumab
Bacillus calmette-guerin substrain tice live antigen may lead to a major life threa... |
DB00586 | DB00741 | 1,512 | 167 | [
"DDInter537",
"DDInter885"
] | Diclofenac | Hydrocortisone | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Moderate | 1 | [
[
[
1512,
24,
167
]
],
[
[
1512,
24,
312
],
[
312,
24,
167
]
],
[
[
1512,
24,
1220
],
[
1220,
40,
167
]
],
[
[
1512,
63,
443
],
[
443,
... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
]
],
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eplerenone"
],
... | Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Eplerenone and Eplerenone may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and... |
DB00294 | DB11767 | 1,336 | 1,583 | [
"DDInter701",
"DDInter1643"
] | Etonogestrel | Sarilumab | Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel. The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001. | Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approve... | Moderate | 1 | [
[
[
1336,
24,
1583
]
],
[
[
1336,
40,
890
],
[
890,
24,
1583
]
],
[
[
1336,
24,
1362
],
[
1362,
24,
1583
]
],
[
[
1336,
63,
58
],
[
58,
... | [
[
[
"Etonogestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarilumab"
]
],
[
[
"Etonogestrel",
"{u} (Compound) resembles {v} (Compound)",
"Mestranol"
],
[
"Mestranol",
"{u} may cause a modera... | Etonogestrel (Compound) resembles Mestranol (Compound) and Mestranol may cause a moderate interaction that could exacerbate diseases when taken with Sarilumab
Etonogestrel may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could ex... |
DB00745 | DB05239 | 307 | 866 | [
"DDInter1236",
"DDInter425"
] | Modafinil | Cobimetinib | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Major | 2 | [
[
[
307,
25,
866
]
],
[
[
307,
24,
214
],
[
214,
63,
866
]
],
[
[
307,
63,
1051
],
[
1051,
24,
866
]
],
[
[
307,
23,
1478
],
[
1478,
... | [
[
[
"Modafinil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobimetinib"
]
],
[
[
"Modafinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
],
[
"Fostamati... | Modafinil may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Cobimetinib
Modafinil may cause a moderate interaction that could exacerbate diseases when taken with Aminoglutethimide ... |
DB00207 | DB01229 | 1,570 | 973 | [
"DDInter157",
"DDInter1377"
] | Azithromycin | Paclitaxel | Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It was initially approved by the FDA in 1991. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually tra... | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Moderate | 1 | [
[
[
1570,
24,
973
]
],
[
[
1570,
6,
8374
],
[
8374,
45,
973
]
],
[
[
1570,
18,
7380
],
[
7380,
46,
973
]
],
[
[
1570,
18,
4677
],
[
4677,
... | [
[
[
"Azithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Azithromycin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Azithromycin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Paclitaxel (Compound)
Azithromycin (Compound) downregulates AKAP8L (Gene) and AKAP8L (Gene) is upregulated by Paclitaxel (Compound)
Azithromycin (Compound) downregulates RFC2 (Gene) and RFC2 (Gene) is downregulated by Paclitaxel (Compound)
Azithr... |
DB00594 | DB01284 | 863 | 1,042 | [
"DDInter68",
"DDInter1782"
] | Amiloride | Tetracosactide | A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions... | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Moderate | 1 | [
[
[
863,
24,
1042
]
],
[
[
863,
24,
123
],
[
123,
24,
1042
]
],
[
[
863,
24,
1450
],
[
1450,
63,
1042
]
],
[
[
863,
63,
1648
],
[
1648,
... | [
[
[
"Amiloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
]
],
[
[
"Amiloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
],
[
... | Amiloride may cause a moderate interaction that could exacerbate diseases when taken with Exenatide and Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Tetracosactide
Amiloride may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Emp... |
DB01041 | DB01042 | 770 | 1,307 | [
"DDInter1789",
"DDInter1144"
] | Thalidomide | Melphalan | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-con... | Major | 2 | [
[
[
770,
25,
1307
]
],
[
[
770,
24,
1191
],
[
1191,
1,
1307
]
],
[
[
770,
5,
11555
],
[
11555,
44,
1307
]
],
[
[
770,
21,
28766
],
[
28766... | [
[
[
"Thalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Melphalan"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levodopa"
],
[
"Levodopa",
... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Levodopa and Levodopa (Compound) resembles Melphalan (Compound)
Thalidomide (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Melphalan (Compound)
Thalidomide (Compound) causes Hypoten... |
DB06273 | DB10316 | 980 | 334 | [
"DDInter1824",
"DDInter1248"
] | Tocilizumab | Mumps virus strain B level jeryl lynn live antigen | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
980,
25,
334
]
],
[
[
980,
64,
1057
],
[
1057,
25,
334
]
],
[
[
980,
25,
908
],
[
908,
25,
334
]
],
[
[
980,
24,
310
],
[
310,
2... | [
[
[
"Tocilizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Tocilizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
... | Tocilizumab may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Mumps virus strain B level jeryl lynn live antigen
Tocilizumab may lead to a major life threatening interaction when taken with Golimumab and Golimumab ... |
DB00444 | DB10429 | 63 | 200 | [
"DDInter1765",
"DDInter282"
] | Teniposide | Candida albicans | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Moderate | 1 | [
[
[
63,
24,
200
]
],
[
[
63,
24,
1683
],
[
1683,
24,
200
]
],
[
[
63,
25,
976
],
[
976,
24,
200
]
],
[
[
63,
63,
168
],
[
168,
24,
... | [
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
]
],
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
],
... | Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans
Teniposide may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib ... |
DB01390 | DB04868 | 1,117 | 478 | [
"DDInter1683",
"DDInter1293"
] | Sodium bicarbonate | Nilotinib | Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions. | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Moderate | 1 | [
[
[
1117,
24,
478
]
],
[
[
1117,
23,
1468
],
[
1468,
63,
478
]
],
[
[
1117,
21,
28963
],
[
28963,
60,
478
]
],
[
[
1117,
25,
1459
],
[
145... | [
[
[
"Sodium bicarbonate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]
],
[
[
"Sodium bicarbonate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ponatinib"
... | Sodium bicarbonate may cause a minor interaction that can limit clinical effects when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib
Sodium bicarbonate (Compound) causes Anxiety (Side Effect) and Anxiety (Side Effect) is caused by Nilotinib (... |
DB00581 | DB01599 | 355 | 1,232 | [
"DDInter1018",
"DDInter1523"
] | Lactulose | Probucol | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993). | Moderate | 1 | [
[
[
355,
24,
1232
]
],
[
[
355,
63,
1555
],
[
1555,
24,
1232
]
],
[
[
355,
24,
927
],
[
927,
63,
1232
]
],
[
[
355,
24,
485
],
[
485,
... | [
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Probucol"
]
],
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin"
],
[
... | Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Probucol
Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encoraf... |
DB06603 | DB08873 | 39 | 74 | [
"DDInter1387",
"DDInter221"
] | Panobinostat | Boceprevir | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Boceprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in... | Major | 2 | [
[
[
39,
25,
74
]
],
[
[
39,
64,
1374
],
[
1374,
23,
74
]
],
[
[
39,
64,
51
],
[
51,
24,
74
]
],
[
[
39,
63,
86
],
[
86,
24,
74... | [
[
[
"Panobinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Boceprevir"
]
],
[
[
"Panobinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Abiraterone"
],
[
"Abiraterone",
... | Panobinostat may lead to a major life threatening interaction when taken with Abiraterone and Abiraterone may cause a minor interaction that can limit clinical effects when taken with Boceprevir
Panobinostat may lead to a major life threatening interaction when taken with Daunorubicin and Daunorubicin may cause a moder... |
DB00515 | DB00827 | 589 | 646 | [
"DDInter387",
"DDInter383"
] | Cisplatin | Cinoxacin | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections. | Minor | 0 | [
[
[
589,
23,
646
]
],
[
[
589,
21,
28722
],
[
28722,
60,
646
]
],
[
[
589,
24,
77
],
[
77,
62,
646
]
],
[
[
589,
63,
322
],
[
322,
2... | [
[
[
"Cisplatin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cinoxacin"
]
],
[
[
"Cisplatin",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused by {v} (... | Cisplatin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Cinoxacin (Compound)
Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Idarubicin and Idarubicin may cause a minor interaction that can limit clinical effects when taken with Cinoxacin
Cisplati... |
DB01101 | DB01320 | 60 | 651 | [
"DDInter285",
"DDInter783"
] | Capecitabine | Fosphenytoin | Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Moderate | 1 | [
[
[
60,
24,
651
]
],
[
[
60,
63,
362
],
[
362,
1,
651
]
],
[
[
60,
6,
6017
],
[
6017,
45,
651
]
],
[
[
60,
21,
29028
],
[
29028,
60,... | [
[
[
"Capecitabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Capecitabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
... | Capecitabine may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Compound)
Capecitabine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Fosphenytoin (Compound)
Capecitabine (Compound) causes Encephalopathy (Side Effect) ... |
DB00814 | DB11095 | 1,171 | 235 | [
"DDInter1143",
"DDInter505"
] | Meloxicam | Desirudin | Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is ... | Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three dis... | Major | 2 | [
[
[
1171,
25,
235
]
],
[
[
1171,
24,
578
],
[
578,
24,
235
]
],
[
[
1171,
24,
738
],
[
738,
63,
235
]
],
[
[
1171,
63,
121
],
[
121,
... | [
[
[
"Meloxicam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Desirudin"
]
],
[
[
"Meloxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
],
[
"Ticagrelor",
... | Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Desirudin
Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib ... |
DB01075 | DB15982 | 1,376 | 1,339 | [
"DDInter569",
"DDInter193"
] | Diphenhydramine | Berotralstat | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat ... | Moderate | 1 | [
[
[
1376,
24,
1339
]
],
[
[
1376,
24,
222
],
[
222,
23,
1339
]
],
[
[
1376,
40,
11
],
[
11,
24,
1339
]
],
[
[
1376,
35,
1264
],
[
1264,
... | [
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Berotralstat"
]
],
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
... | Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Berotralstat
Diphenhydramine (Compound) resembles Toremifene (Compound) and Toremifene may cause a moderate interactio... |
DB01064 | DB01193 | 1,148 | 819 | [
"DDInter987",
"DDInter12"
] | Isoprenaline | Acebutolol | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. | Moderate | 1 | [
[
[
1148,
24,
819
]
],
[
[
1148,
63,
887
],
[
887,
1,
819
]
],
[
[
1148,
6,
3576
],
[
3576,
45,
819
]
],
[
[
1148,
21,
28762
],
[
28762,
... | [
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acebutolol"
]
],
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pindolol"
],
[
... | Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Pindolol and Pindolol (Compound) resembles Acebutolol (Compound)
Isoprenaline (Compound) binds ADRB2 (Gene) and ADRB2 (Gene) is bound by Acebutolol (Compound)
Isoprenaline (Compound) causes Headache (Side Effect) and Headache (... |
DB01607 | DB09420 | 1,390 | 1,074 | [
"DDInter1803",
"DDInter953"
] | Ticarcillin | Iodide I-123 | An antibiotic derived from penicillin similar to carbenicillin in action. | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Moderate | 1 | [
[
[
1390,
24,
1074
]
],
[
[
1390,
40,
339
],
[
339,
24,
1074
]
],
[
[
1390,
63,
126
],
[
126,
24,
1074
]
],
[
[
1390,
1,
790
],
[
790,
... | [
[
[
"Ticarcillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
]
],
[
[
"Ticarcillin",
"{u} (Compound) resembles {v} (Compound)",
"Bacampicillin"
],
[
"Bacampicillin",
"{u} may cause... | Ticarcillin (Compound) resembles Bacampicillin (Compound) and Bacampicillin may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123
Ticarcillin may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate interaction that... |
DB01185 | DB01284 | 155 | 1,042 | [
"DDInter759",
"DDInter1782"
] | Fluoxymesterone | Tetracosactide | An anabolic steroid that has been used in the treatment of male hypogonadism, delayed puberty in males, and in the treatment of breast neoplasms in women. | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Moderate | 1 | [
[
[
155,
24,
1042
]
],
[
[
155,
1,
1561
],
[
1561,
24,
1042
]
],
[
[
155,
63,
1144
],
[
1144,
24,
1042
]
],
[
[
155,
1,
1687
],
[
1687,
... | [
[
[
"Fluoxymesterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
]
],
[
[
"Fluoxymesterone",
"{u} (Compound) resembles {v} (Compound)",
"Testosterone"
],
[
"Testosterone",
"{u} m... | Fluoxymesterone (Compound) resembles Testosterone (Compound) and Testosterone may cause a moderate interaction that could exacerbate diseases when taken with Tetracosactide
Fluoxymesterone may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide may cause a moderate in... |
DB00367 | DB00491 | 566 | 127 | [
"DDInter1061",
"DDInter1217"
] | Levonorgestrel | Miglitol | Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of ... | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | Moderate | 1 | [
[
[
566,
24,
127
]
],
[
[
566,
21,
29180
],
[
29180,
60,
127
]
],
[
[
566,
1,
984
],
[
984,
63,
127
]
],
[
[
566,
40,
989
],
[
989,
... | [
[
[
"Levonorgestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miglitol"
]
],
[
[
"Levonorgestrel",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal distension"
],
[
"Abdominal distension",
... | Levonorgestrel (Compound) causes Abdominal distension (Side Effect) and Abdominal distension (Side Effect) is caused by Miglitol (Compound)
Levonorgestrel (Compound) resembles Danazol (Compound) and Danazol may cause a moderate interaction that could exacerbate diseases when taken with Miglitol
Levonorgestrel (Compound... |
DB06228 | DB15035 | 792 | 503 | [
"DDInter1609",
"DDInter1959"
] | Rivaroxaban | Zanubrutinib | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Major | 2 | [
[
[
792,
25,
503
]
],
[
[
792,
24,
982
],
[
982,
24,
503
]
],
[
[
792,
63,
222
],
[
222,
24,
503
]
],
[
[
792,
25,
39
],
[
39,
25,
... | [
[
[
"Rivaroxaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivosidenib"
],
[
"Ivosid... | Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Ivosidenib and Ivosidenib may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and S... |
DB08912 | DB11932 | 1,040 | 327 | [
"DDInter462",
"DDInter3"
] | Dabrafenib | Abametapir (topical) | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Abametapir is a member of bipyridines. | Moderate | 1 | [
[
[
1040,
24,
327
]
],
[
[
1040,
25,
124
],
[
124,
63,
327
]
],
[
[
1040,
62,
168
],
[
168,
24,
327
]
],
[
[
1040,
63,
292
],
[
292,
... | [
[
[
"Dabrafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abametapir"
]
],
[
[
"Dabrafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glasdegib"
],
[
"Glasdegib",... | Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Dabrafenib may lead to a major life threatening interaction when taken with Glasdegib and Glasdegib may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Dabrafenib may cause a mino... |
DB00290 | DB00363 | 329 | 695 | [
"DDInter219",
"DDInter419"
] | Bleomycin | Clozapine | A complex of related glycopeptide antibiotics from <i>Streptomyces verticillus</i> consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin. | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Major | 2 | [
[
[
329,
25,
695
]
],
[
[
329,
24,
1001
],
[
1001,
64,
695
]
],
[
[
329,
63,
552
],
[
552,
25,
695
]
],
[
[
329,
24,
141
],
[
141,
2... | [
[
[
"Bleomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clozapine"
]
],
[
[
"Bleomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mechlorethamine"
],
[
"Mechlore... | Bleomycin may cause a moderate interaction that could exacerbate diseases when taken with Mechlorethamine and Mechlorethamine may lead to a major life threatening interaction when taken with Clozapine
Bleomycin may cause a moderate interaction that could exacerbate diseases when taken with Carmustine and Carmustine may... |
DB00106 | DB05294 | 618 | 1,069 | [
"DDInter4",
"DDInter1917"
] | Abarelix | Vandetanib | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Major | 2 | [
[
[
618,
25,
1069
]
],
[
[
618,
23,
1247
],
[
1247,
23,
1069
]
],
[
[
618,
24,
659
],
[
659,
63,
1069
]
],
[
[
618,
24,
688
],
[
688,
... | [
[
[
"Abarelix",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vandetanib"
]
],
[
[
"Abarelix",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"Sulfametho... | Abarelix may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Vandetanib
Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vi... |
DB00682 | DB01603 | 126 | 1,366 | [
"DDInter1951",
"DDInter1195"
] | Warfarin | Meticillin | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | One of the penicillins which is resistant to penicillinase but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection. | Moderate | 1 | [
[
[
126,
24,
1366
]
],
[
[
126,
63,
790
],
[
790,
40,
1366
]
],
[
[
126,
24,
950
],
[
950,
40,
1366
]
],
[
[
126,
64,
916
],
[
916,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meticillin"
]
],
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Piperacillin"
],
[
... | Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Piperacillin and Piperacillin (Compound) resembles Meticillin (Compound)
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Cloxacillin and Cloxacillin (Compound) resembles Meticillin (Compound... |
DB00207 | DB00581 | 1,570 | 355 | [
"DDInter157",
"DDInter1018"
] | Azithromycin | Lactulose | Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It was initially approved by the FDA in 1991. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually tra... | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Moderate | 1 | [
[
[
1570,
24,
355
]
],
[
[
1570,
21,
28722
],
[
28722,
60,
355
]
],
[
[
1570,
24,
115
],
[
115,
62,
355
]
],
[
[
1570,
24,
79
],
[
79,
... | [
[
[
"Azithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lactulose"
]
],
[
[
"Azithromycin",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused ... | Azithromycin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Lactulose (Compound)
Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Aluminum hydroxide and Aluminum hydroxide may cause a minor interaction that can limit clinical effects when taken w... |
DB00969 | DB11730 | 2 | 351 | [
"DDInter52",
"DDInter1588"
] | Alosetron | Ribociclib | Alosetron is a 5-HT3 antagonist used only for the management of severe diarrhoea-predominant irritable bowel syndrome (IBS) in women. Alosetron has an antagonist action on the 5-HT3 receptors and thus may modulate serotonin-sensitive gastrointestinal (GI) processes. Alosetron was voluntarily withdrawn from the US marke... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
2,
24,
351
]
],
[
[
2,
24,
875
],
[
875,
24,
351
]
],
[
[
2,
24,
1033
],
[
1033,
63,
351
]
],
[
[
2,
64,
529
],
[
529,
24,
... | [
[
[
"Alosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Alosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosaprepitant"
],
[
... | Alosetron may cause a moderate interaction that could exacerbate diseases when taken with Fosaprepitant and Fosaprepitant may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib
Alosetron may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and Alp... |
DB00620 | DB12825 | 175 | 1,375 | [
"DDInter1855",
"DDInter1032"
] | Triamcinolone | Lefamulin | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Moderate | 1 | [
[
[
175,
24,
1375
]
],
[
[
175,
24,
159
],
[
159,
63,
1375
]
],
[
[
175,
25,
976
],
[
976,
24,
1375
]
],
[
[
175,
63,
1101
],
[
1101,
... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
]
],
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
... | Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin
Triamcinolone may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitin... |
DB00241 | DB08899 | 288 | 129 | [
"DDInter257",
"DDInter649"
] | Butalbital | Enzalutamide | Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervou... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
288,
24,
129
]
],
[
[
288,
24,
112
],
[
112,
23,
129
]
],
[
[
288,
23,
608
],
[
608,
23,
129
]
],
[
[
288,
24,
79
],
[
79,
24,
... | [
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Enzalutamide
Butalbital may cause a minor interaction that can limit clinical effects when taken with Lidocaine and Lid... |
DB00095 | DB00619 | 66 | 1,419 | [
"DDInter623",
"DDInter909"
] | Efalizumab | Imatinib | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Moderate | 1 | [
[
[
66,
24,
1419
]
],
[
[
66,
24,
1101
],
[
1101,
23,
1419
]
],
[
[
66,
24,
309
],
[
309,
63,
1419
]
],
[
[
66,
63,
599
],
[
599,
24... | [
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
]
],
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Imatinib
Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixabepilo... |
DB01249 | DB12615 | 258 | 1,381 | [
"DDInter958",
"DDInter1482"
] | Iodixanol | Plazomicin | Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents. | Developed by Achaogen biopharmaceuticals, plazomicin is a next-generation aminoglycoside synthetically derived from . The structure of plazomicin was established via appending hydroxylaminobutyric acid to at position 1 and 2-hydroxyethyl group at position 6' . It was designed to evade all clinically relevant aminoglyco... | Major | 2 | [
[
[
258,
25,
1381
]
],
[
[
258,
64,
416
],
[
416,
24,
1381
]
],
[
[
258,
25,
712
],
[
712,
24,
1381
]
],
[
[
258,
64,
1441
],
[
1441,
... | [
[
[
"Iodixanol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Plazomicin"
]
],
[
[
"Iodixanol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Kanamycin"
],
[
"Kanamycin",
"{u} may c... | Iodixanol may lead to a major life threatening interaction when taken with Kanamycin and Kanamycin may cause a moderate interaction that could exacerbate diseases when taken with Plazomicin
Iodixanol may lead to a major life threatening interaction when taken with Olsalazine and Olsalazine may cause a moderate interact... |
DB00468 | DB06207 | 1,424 | 910 | [
"DDInter1557",
"DDInter1667"
] | Quinine | Silodosin | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Silodosin is a selective antagonist of alpha(α)-1 adrenergic receptors that binds to the α<sub>1A</sub> subtype with the highest affinity. α1-adrenergic receptors regulate smooth muscle tone in the bladder neck, prostate, and prostatic urethra: the α<sub>1A</sub> subtype accounts for approximately 75% of α1-adrenocepto... | Moderate | 1 | [
[
[
1424,
24,
910
]
],
[
[
1424,
6,
8374
],
[
8374,
45,
910
]
],
[
[
1424,
21,
28921
],
[
28921,
60,
910
]
],
[
[
1424,
63,
353
],
[
353,
... | [
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Silodosin"
]
],
[
[
"Quinine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Quinine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Silodosin (Compound)
Quinine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Silodosin (Compound)
Quinine may cause a moderate interaction that could exacerbate diseases when taken with Griseofulvin and Griseofulvin ... |
DB00264 | DB00364 | 88 | 417 | [
"DDInter1200",
"DDInter1717"
] | Metoprolol | Sucralfate | Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succi... | Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia . It is considered a _cytoprotective agent_, protec... | Minor | 0 | [
[
[
88,
23,
417
]
],
[
[
88,
21,
28882
],
[
28882,
60,
417
]
],
[
[
88,
40,
17
],
[
17,
62,
417
]
],
[
[
88,
1,
819
],
[
819,
62,
... | [
[
[
"Metoprolol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sucralfate"
]
],
[
[
"Metoprolol",
"{u} (Compound) causes {v} (Side Effect)",
"Body temperature increased"
],
[
"Body temperature increased",
... | Metoprolol (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Sucralfate (Compound)
Metoprolol (Compound) resembles Sotalol (Compound) and Sotalol may cause a minor interaction that can limit clinical effects when taken with Sucralfate
Metoprolol (Compou... |
DB00845 | DB11110 | 1,490 | 603 | [
"DDInter406",
"DDInter1115"
] | Clofazimine | Magnesium citrate | Clofazimine is a highly lipophilic antimicrobial riminophenazine dye used in combination with other agents, such as [dapsone], for the treatment of leprosy. It was originally described in 1957 and was the prototypical riminophenazine dye - a bright-red dye that, in its clinical use, results in long-lasting discoloratio... | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
1490,
24,
603
]
],
[
[
1490,
25,
57
],
[
57,
24,
603
]
],
[
[
1490,
24,
1616
],
[
1616,
24,
603
]
],
[
[
1490,
24,
484
],
[
484,
... | [
[
[
"Clofazimine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Clofazimine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
[
... | Clofazimine may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Clofazimine may cause a moderate interaction that could exacerbate diseases when taken with Histrelin and H... |
DB00673 | DB12674 | 723 | 975 | [
"DDInter112",
"DDInter1105"
] | Aprepitant | Lurbinectedin | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative of the marine-derived agent ecteinascidin ([trabectedin]), an anticancer agent fou... | Major | 2 | [
[
[
723,
25,
975
]
],
[
[
723,
24,
159
],
[
159,
63,
975
]
],
[
[
723,
24,
98
],
[
98,
24,
975
]
],
[
[
723,
63,
147
],
[
147,
24,
... | [
[
[
"Aprepitant",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lurbinectedin"
]
],
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
[
"Laro... | Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin
Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and... |
DB00816 | DB06262 | 1,674 | 1,354 | [
"DDInter1346",
"DDInter606"
] | Orciprenaline | Droxidopa | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Droxidopa is a precursor of noradrenaline that is used in the treatment of Parkinsonism. It is approved for use in Japan and is currently in trials in the U.S. The racaemic form (dl-threo-3,4-dihydroxyphenylserine) has also been used, and has been investigated in the treatment of orthostatic hypotension. There is a def... | Moderate | 1 | [
[
[
1674,
24,
1354
]
],
[
[
1674,
63,
874
],
[
874,
24,
1354
]
],
[
[
1674,
24,
584
],
[
584,
40,
1354
]
],
[
[
1674,
35,
1148
],
[
1148,
... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Droxidopa"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
],
... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Droxidopa
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Levonordefrin ... |
DB00327 | DB00719 | 421 | 1,219 | [
"DDInter890",
"DDInter149"
] | Hydromorphone | Azatadine | Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of [morphine] that has been available clinically since 1920. Structurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 a... | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Moderate | 1 | [
[
[
421,
24,
1219
]
],
[
[
421,
24,
13
],
[
13,
24,
1219
]
],
[
[
421,
24,
830
],
[
830,
1,
1219
]
],
[
[
421,
6,
8374
],
[
8374,
45... | [
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azatadine"
]
],
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],... | Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Pheninda... |
DB00762 | DB08912 | 613 | 1,040 | [
"DDInter973",
"DDInter462"
] | Irinotecan | Dabrafenib | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
613,
24,
1040
]
],
[
[
613,
6,
4973
],
[
4973,
45,
1040
]
],
[
[
613,
7,
2969
],
[
2969,
46,
1040
]
],
[
[
613,
18,
10351
],
[
10351,
... | [
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Irinotecan",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Irinotecan (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dabrafenib (Compound)
Irinotecan (Compound) upregulates CDKN1A (Gene) and CDKN1A (Gene) is upregulated by Dabrafenib (Compound)
Irinotecan (Compound) downregulates ATF6 (Gene) and ATF6 (Gene) is upregulated by Dabrafenib (Compound)
Irinotecan (Compou... |
DB01278 | DB01309 | 1,021 | 1,254 | [
"DDInter1506",
"DDInter933"
] | Pramlintide | Insulin glulisine | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
1021,
24,
1254
]
],
[
[
1021,
62,
1103
],
[
1103,
23,
1254
]
],
[
[
1021,
24,
1033
],
[
1033,
63,
1254
]
],
[
[
1021,
63,
167
],
[
167... | [
[
[
"Pramlintide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Pramlintide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
],
... | Pramlintide may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Insulin glulisine
Pramlintide may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and Al... |
DB00673 | DB06212 | 723 | 165 | [
"DDInter112",
"DDInter1833"
] | Aprepitant | Tolvaptan | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Tolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009. | Moderate | 1 | [
[
[
723,
24,
165
]
],
[
[
723,
24,
1080
],
[
1080,
1,
165
]
],
[
[
723,
63,
522
],
[
522,
1,
165
]
],
[
[
723,
6,
8374
],
[
8374,
45... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolvaptan"
]
],
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Conivaptan"
],
[
... | Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Conivaptan and Conivaptan (Compound) resembles Tolvaptan (Compound)
Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Zafirlukast and Zafirlukast (Compound) resembles Tolvaptan (Compound)
... |
DB00434 | DB01075 | 13 | 1,376 | [
"DDInter459",
"DDInter569"
] | Cyproheptadine | Diphenhydramine | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
13,
24,
1376
]
],
[
[
13,
24,
649
],
[
649,
63,
1376
]
],
[
[
13,
63,
128
],
[
128,
24,
1376
]
],
[
[
13,
24,
832
],
[
832,
24,
... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
... | Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Dexbromp... |
DB00443 | DB08912 | 251 | 1,040 | [
"DDInter195",
"DDInter462"
] | Betamethasone | Dabrafenib | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
251,
24,
1040
]
],
[
[
251,
7,
8922
],
[
8922,
45,
1040
]
],
[
[
251,
6,
4973
],
[
4973,
45,
1040
]
],
[
[
251,
7,
18182
],
[
18182,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Betamethasone",
"{u} (Compound) upregulates {v} (Gene)",
"SIK1"
],
[
"SIK1",
"{u} (Gene) is bound by {v} (Com... | Betamethasone (Compound) upregulates SIK1 (Gene) and SIK1 (Gene) is bound by Dabrafenib (Compound)
Betamethasone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dabrafenib (Compound)
Betamethasone (Compound) upregulates PECR (Gene) and PECR (Gene) is upregulated by Dabrafenib (Compound)
Betamethasone (Compou... |
DB00280 | DB08881 | 494 | 868 | [
"DDInter575",
"DDInter1925"
] | Disopyramide | Vemurafenib | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Major | 2 | [
[
[
494,
25,
868
]
],
[
[
494,
6,
8374
],
[
8374,
45,
868
]
],
[
[
494,
21,
28714
],
[
28714,
60,
868
]
],
[
[
494,
40,
211
],
[
211,
... | [
[
[
"Disopyramide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
]
],
[
[
"Disopyramide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Ve... | Disopyramide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vemurafenib (Compound)
Disopyramide (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Vemurafenib (Compound)
Disopyramide (Compound) resembles Tolterodine (Compound) and Tolterodine may cause a minor interaction tha... |
DB00252 | DB12364 | 362 | 1,421 | [
"DDInter1460",
"DDInter200"
] | Phenytoin | Betrixaban | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Moderate | 1 | [
[
[
362,
24,
1421
]
],
[
[
362,
25,
1513
],
[
1513,
24,
1421
]
],
[
[
362,
1,
759
],
[
759,
24,
1421
]
],
[
[
362,
24,
1320
],
[
1320,
... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betrixaban"
]
],
[
[
"Phenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apremilast"
],
[
"Apremilast",... | Phenytoin may lead to a major life threatening interaction when taken with Apremilast and Apremilast may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Phenytoin (Compound) resembles Primidone (Compound) and Primidone may cause a moderate interaction that could exacerbate disease... |
DB00692 | DB01142 | 274 | 1,264 | [
"DDInter1448",
"DDInter593"
] | Phentolamine | Doxepin | Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
274,
24,
1264
]
],
[
[
274,
63,
508
],
[
508,
24,
1264
]
],
[
[
274,
24,
401
],
[
401,
24,
1264
]
],
[
[
274,
6,
5299
],
[
5299,
... | [
[
[
"Phentolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Phentolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promazine"
],
[
... | Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Prome... |
DB00427 | DB00810 | 1,233 | 456 | [
"DDInter1879",
"DDInter211"
] | Triprolidine | Biperiden | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine. | Moderate | 1 | [
[
[
1233,
24,
456
]
],
[
[
1233,
63,
1105
],
[
1105,
40,
456
]
],
[
[
1233,
1,
11268
],
[
11268,
40,
456
]
],
[
[
1233,
6,
12523
],
[
1252... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Biperiden"
]
],
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trihexyphenidyl"
],
... | Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Trihexyphenidyl and Trihexyphenidyl (Compound) resembles Biperiden (Compound)
Triprolidine (Compound) resembles Cloperastine (Compound) and Cloperastine (Compound) resembles Biperiden (Compound)
Triprolidine (Compound) binds CY... |
DB00314 | DB01276 | 894 | 123 | [
"DDInter288",
"DDInter706"
] | Capreomycin | Exenatide | Cyclic peptide antibiotic similar to viomycin. It is produced by Streptomyces capreolus. | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Moderate | 1 | [
[
[
894,
24,
123
]
],
[
[
894,
24,
708
],
[
708,
63,
123
]
],
[
[
894,
24,
1573
],
[
1573,
24,
123
]
],
[
[
894,
25,
361
],
[
361,
2... | [
[
[
"Capreomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
]
],
[
[
"Capreomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
],
... | Capreomycin may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin and Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Exenatide
Capreomycin may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and... |
DB00348 | DB01232 | 254 | 1,327 | [
"DDInter1300",
"DDInter1640"
] | Nitisinone | Saquinavir | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Moderate | 1 | [
[
[
254,
24,
1327
]
],
[
[
254,
63,
798
],
[
798,
40,
1327
]
],
[
[
254,
24,
915
],
[
915,
40,
1327
]
],
[
[
254,
21,
28691
],
[
28691,
... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saquinavir"
]
],
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nelfinavir"
],
[
... | Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Nelfinavir and Nelfinavir (Compound) resembles Saquinavir (Compound)
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Atazanavir and Atazanavir (Compound) resembles Saquinavir (Compound)
... |
DB06212 | DB08870 | 165 | 850 | [
"DDInter1833",
"DDInter228"
] | Tolvaptan | Brentuximab vedotin | Tolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009. | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
165,
24,
850
]
],
[
[
165,
63,
896
],
[
896,
24,
850
]
],
[
[
165,
24,
1033
],
[
1033,
63,
850
]
],
[
[
165,
64,
609
],
[
609,
2... | [
[
[
"Tolvaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Tolvaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
],
... | Tolvaptan may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Tolvaptan may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and Al... |
DB00405 | DB00906 | 128 | 1,567 | [
"DDInter517",
"DDInter1801"
] | Dexbrompheniramine | Tiagabine | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Tiagabine is an anti-convulsive medication. It is also used in the treatment for panic disorder as are a few other anticonvulsants. Though the exact mechanism by which tiagabine exerts its effect on the human body is unknown, it does appear to operate as a selective GABA reuptake inhibitor. | Moderate | 1 | [
[
[
128,
24,
1567
]
],
[
[
128,
24,
530
],
[
530,
24,
1567
]
],
[
[
128,
24,
537
],
[
537,
63,
1567
]
],
[
[
128,
74,
1594
],
[
1594,
... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tiagabine"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Tiagabine
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Cycliz... |
DB06699 | DB11113 | 774 | 657 | [
"DDInter493",
"DDInter307"
] | Degarelix | Castor oil | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of , which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic... | Moderate | 1 | [
[
[
774,
24,
657
]
],
[
[
774,
63,
1079
],
[
1079,
24,
657
]
],
[
[
774,
24,
927
],
[
927,
63,
657
]
],
[
[
774,
64,
540
],
[
540,
2... | [
[
[
"Degarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Castor oil"
]
],
[
[
"Degarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telavancin"
],
[
... | Degarelix may cause a moderate interaction that could exacerbate diseases when taken with Telavancin and Telavancin may cause a moderate interaction that could exacerbate diseases when taken with Castor oil
Degarelix may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encoraf... |
DB00204 | DB06788 | 228 | 1,616 | [
"DDInter580",
"DDInter864"
] | Dofetilide | Histrelin | Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter. | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Major | 2 | [
[
[
228,
25,
1616
]
],
[
[
228,
23,
112
],
[
112,
23,
1616
]
],
[
[
228,
25,
1342
],
[
1342,
24,
1616
]
],
[
[
228,
24,
603
],
[
603,
... | [
[
[
"Dofetilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Histrelin"
]
],
[
[
"Dofetilide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidaz... | Dofetilide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Dofetilide may lead to a major life threatening interaction when taken with Romidepsin and Romidepsin may cause... |
DB00055 | DB00261 | 834 | 702 | [
"DDInter605",
"DDInter93"
] | Drotrecogin alfa | Anagrelide | Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated th... | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Major | 2 | [
[
[
834,
25,
702
]
],
[
[
834,
23,
539
],
[
539,
62,
702
]
],
[
[
834,
25,
935
],
[
935,
63,
702
]
],
[
[
834,
24,
109
],
[
109,
63,... | [
[
[
"Drotrecogin alfa",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Anagrelide"
]
],
[
[
"Drotrecogin alfa",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Ca... | Drotrecogin alfa may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Anagrelide
Drotrecogin alfa may lead to a major life threatening interaction when taken with Ketoprofen and Ketoprofen may ca... |
DB00381 | DB00877 | 376 | 629 | [
"DDInter79",
"DDInter1678"
] | Amlodipine | Sirolimus | Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial... | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Moderate | 1 | [
[
[
376,
24,
629
]
],
[
[
376,
6,
4973
],
[
4973,
45,
629
]
],
[
[
376,
7,
2620
],
[
2620,
46,
629
]
],
[
[
376,
18,
17017
],
[
17017,
... | [
[
[
"Amlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
]
],
[
[
"Amlodipine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Amlodipine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sirolimus (Compound)
Amlodipine (Compound) upregulates CCNG2 (Gene) and CCNG2 (Gene) is upregulated by Sirolimus (Compound)
Amlodipine (Compound) downregulates CD320 (Gene) and CD320 (Gene) is downregulated by Sirolimus (Compound)
Amlodipine (Compoun... |
DB01396 | DB11158 | 1,482 | 1,452 | [
"DDInter553",
"DDInter1401"
] | Digitoxin | Pectin | A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665) | Pectin is a heteropolysaccharide commercially derived from the cell wall of higher plants. It is composed of partially methylated polygalacturonic acid units linked in the positions 1-4. The carboxylic group of the constituents of pectin can exist in the form of esters, free acids, ammonium, potassium or sodium salts o... | Moderate | 1 | [
[
[
1482,
24,
1452
]
],
[
[
1482,
40,
1252
],
[
1252,
24,
1452
]
],
[
[
1482,
6,
4973
],
[
4973,
45,
681
],
[
681,
24,
1452
]
],
[
[
1482,... | [
[
[
"Digitoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pectin"
]
],
[
[
"Digitoxin",
"{u} (Compound) resembles {v} (Compound)",
"Digoxin"
],
[
"Digoxin",
"{u} may cause a moderate interactio... | Digitoxin (Compound) resembles Digoxin (Compound) and Digoxin may cause a moderate interaction that could exacerbate diseases when taken with Pectin
Digitoxin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Pravastatin (Compound) and Pravastatin may cause a moderate interaction that could exacerbate diseases... |
DB00470 | DB01136 | 530 | 772 | [
"DDInter601",
"DDInter305"
] | Dronabinol | Carvedilol | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Moderate | 1 | [
[
[
530,
24,
772
]
],
[
[
530,
6,
9842
],
[
9842,
45,
772
]
],
[
[
530,
21,
28734
],
[
28734,
60,
772
]
],
[
[
530,
63,
475
],
[
475,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carvedilol"
]
],
[
[
"Dronabinol",
"{u} (Compound) binds {v} (Gene)",
"CYP1A1"
],
[
"CYP1A1",
"{u} (Gene) is bound by {v} (Compound)",... | Dronabinol (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Carvedilol (Compound)
Dronabinol (Compound) causes Immune system disorder (Side Effect) and Immune system disorder (Side Effect) is caused by Carvedilol (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when take... |
DB00502 | DB01064 | 1,300 | 1,148 | [
"DDInter853",
"DDInter987"
] | Haloperidol | Isoprenaline | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Major | 2 | [
[
[
1300,
25,
1148
]
],
[
[
1300,
24,
480
],
[
480,
24,
1148
]
],
[
[
1300,
6,
9842
],
[
9842,
45,
1148
]
],
[
[
1300,
18,
2183
],
[
2183,... | [
[
[
"Haloperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Isoprenaline"
]
],
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
[
"Formot... | Haloperidol may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Haloperidol (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Isoprenaline (Compound)
Haloperidol ... |
DB00388 | DB00780 | 1,636 | 551 | [
"DDInter1453",
"DDInter1440"
] | Phenylephrine | Phenelzine | Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939. | Phenelzine, with the formula β-phenylethylhydrazine, is a monoamine oxidase inhibiting antidepressant that is effective in the treatment of panic disorder and social anxiety disorder. It was developed by Parke Davis and originally FDA approved on June 9th, 1961. It is currently approved under prescription by the name o... | Major | 2 | [
[
[
1636,
25,
551
]
],
[
[
1636,
25,
1161
],
[
1161,
40,
551
]
],
[
[
1636,
24,
633
],
[
633,
40,
551
]
],
[
[
1636,
63,
73
],
[
73,
... | [
[
[
"Phenylephrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phenelzine"
]
],
[
[
"Phenylephrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Selegiline"
],
[
"Selegiline",
... | Phenylephrine may lead to a major life threatening interaction when taken with Selegiline and Selegiline (Compound) resembles Phenelzine (Compound)
Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Lisdexamfetamine and Lisdexamfetamine (Compound) resembles Phenelzine (Compoun... |
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