drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00938 | DB01367 | 455 | 1,163 | [
"DDInter1635",
"DDInter1572"
] | Salmeterol | Rasagiline | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases. | Moderate | 1 | [
[
[
455,
24,
1163
]
],
[
[
455,
21,
28714
],
[
28714,
60,
1163
]
],
[
[
455,
24,
1520
],
[
1520,
24,
1163
]
],
[
[
455,
63,
1445
],
[
1445... | [
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rasagiline"
]
],
[
[
"Salmeterol",
"{u} (Compound) causes {v} (Side Effect)",
"Asthenia"
],
[
"Asthenia",
"{u} (Side Effect) is caused... | Salmeterol (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Rasagiline (Compound)
Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Primaquine and Primaquine may cause a moderate interaction that could exacerbate diseases when taken with Rasagilin... |
DB00041 | DB00708 | 1,648 | 1,454 | [
"DDInter38",
"DDInter1718"
] | Aldesleukin | Sufentanil | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to w... | Moderate | 1 | [
[
[
1648,
24,
1454
]
],
[
[
1648,
24,
704
],
[
704,
40,
1454
]
],
[
[
1648,
24,
537
],
[
537,
63,
1454
]
],
[
[
1648,
24,
1419
],
[
1419,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sufentanil"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fentanyl"
],
[
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl (Compound) resembles Sufentanil (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine may cause a moderate interaction that could exa... |
DB01075 | DB01116 | 1,376 | 601 | [
"DDInter569",
"DDInter1872"
] | Diphenhydramine | Trimethaphan | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | A nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hypotension during surgery. | Moderate | 1 | [
[
[
1376,
24,
601
]
],
[
[
1376,
1,
11364
],
[
11364,
1,
601
]
],
[
[
1376,
40,
11286
],
[
11286,
1,
601
]
],
[
[
1376,
63,
357
],
[
357,
... | [
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimethaphan"
]
],
[
[
"Diphenhydramine",
"{u} (Compound) resembles {v} (Compound)",
"Alverine"
],
[
"Alverine",
"{u} (Compound) ... | Diphenhydramine (Compound) resembles Alverine (Compound) and Alverine (Compound) resembles Trimethaphan (Compound)
Diphenhydramine (Compound) resembles Diphenylpyraline (Compound) and Diphenylpyraline (Compound) resembles Trimethaphan (Compound)
Diphenhydramine may cause a moderate interaction that could exacerbate dis... |
DB00312 | DB14723 | 1,023 | 159 | [
"DDInter1423",
"DDInter1026"
] | Pentobarbital | Larotrectinib | A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Dr... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
1023,
24,
159
]
],
[
[
1023,
24,
222
],
[
222,
23,
159
]
],
[
[
1023,
24,
741
],
[
741,
24,
159
]
],
[
[
1023,
62,
608
],
[
608,
... | [
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]... | Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant a... |
DB00294 | DB01254 | 1,336 | 1,213 | [
"DDInter701",
"DDInter484"
] | Etonogestrel | Dasatinib | Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel. The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001. | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
1336,
24,
1213
]
],
[
[
1336,
6,
8374
],
[
8374,
45,
1213
]
],
[
[
1336,
21,
28882
],
[
28882,
60,
1213
]
],
[
[
1336,
24,
1619
],
[
1... | [
[
[
"Etonogestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Etonogestrel",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Etonogestrel (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dasatinib (Compound)
Etonogestrel (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Dasatinib (Compound)
Etonogestrel may cause a moderate interaction that could exacerbate diseas... |
DB01126 | DB01254 | 1,260 | 1,213 | [
"DDInter611",
"DDInter484"
] | Dutasteride | Dasatinib | Dutasteride is an oral synthetic 4-azasteroid commonly marketed under the trade name Avodart. It is a novel dual 5α-reductase inhibitor that works by blocking both isoforms of 5α-reductase enzymes in a potent, selective, and irreversible manner. Type I and II 5α-reductase enzymes convert testosterone into dihydrotestos... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
1260,
24,
1213
]
],
[
[
1260,
6,
8374
],
[
8374,
45,
1213
]
],
[
[
1260,
21,
28894
],
[
28894,
60,
1213
]
],
[
[
1260,
24,
1619
],
[
1... | [
[
[
"Dutasteride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Dutasteride",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Dutasteride (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dasatinib (Compound)
Dutasteride (Compound) causes Cardiac failure (Side Effect) and Cardiac failure (Side Effect) is caused by Dasatinib (Compound)
Dutasteride may cause a moderate interaction that could exacerbate diseases when taken with Rucapa... |
DB09038 | DB12035 | 1,450 | 943 | [
"DDInter636",
"DDInter1641"
] | Empagliflozin | Sarecycline | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Sarecycline is a semi-synthetic derivative of tetracycline that was initially discovered by Paratek Pharmaceuticals from Boston, MA but then licensed to Warner Chilcott of Rockaway, NJ in July of 2007 . After completing various phase-II and phase-III trials demonstrating its effectiveness in treating moderate to severe... | Moderate | 1 | [
[
[
1450,
24,
943
]
],
[
[
1450,
63,
850
],
[
850,
24,
943
]
],
[
[
1450,
24,
971
],
[
971,
63,
943
]
],
[
[
1450,
63,
850
],
[
850,
... | [
[
[
"Empagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarecycline"
]
],
[
[
"Empagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"... | Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin and Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Sarecycline
Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00928 | DB08868 | 1,426 | 1,011 | [
"DDInter148",
"DDInter737"
] | Azacitidine | Fingolimod | Azacitidine is a pyrimidine nucleoside analogue with anti-neoplastic activity. It differs from cytosine by the presence of nitrogen in the C5-position, key in its hypomethylating activity.[A1406,A1413,A1415] Two main mechanisms of action have been proposed for azacitidine. One of them is the induction of cytotoxicity. ... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
1426,
25,
1011
]
],
[
[
1426,
21,
28792
],
[
28792,
60,
1011
]
],
[
[
1426,
24,
748
],
[
748,
63,
1011
]
],
[
[
1426,
24,
1136
],
[
11... | [
[
[
"Azacitidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Azacitidine",
"{u} (Compound) causes {v} (Side Effect)",
"Gastrointestinal disorder"
],
[
"Gastrointestinal disorder",
"{u} (S... | Azacitidine (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Fingolimod (Compound)
Azacitidine may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine and Anthrax vaccine may cause a moderate interaction that could... |
DB00213 | DB01082 | 837 | 1,448 | [
"DDInter1388",
"DDInter1713"
] | Pantoprazole | Streptomycin | Pantoprazole is a first-generation proton pump inhibitor (PPI) used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zolling... | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | Moderate | 1 | [
[
[
837,
24,
1448
]
],
[
[
837,
21,
28882
],
[
28882,
60,
1448
]
],
[
[
837,
24,
361
],
[
361,
24,
1448
]
],
[
[
837,
1,
1215
],
[
1215,
... | [
[
[
"Pantoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Streptomycin"
]
],
[
[
"Pantoprazole",
"{u} (Compound) causes {v} (Side Effect)",
"Body temperature increased"
],
[
"Body temperature incr... | Pantoprazole (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Streptomycin (Compound)
Pantoprazole may cause a moderate interaction that could exacerbate diseases when taken with Neomycin and Neomycin may cause a moderate interaction that could exacerb... |
DB00358 | DB00381 | 1,010 | 376 | [
"DDInter1140",
"DDInter79"
] | Mefloquine | Amlodipine | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial... | Moderate | 1 | [
[
[
1010,
24,
376
]
],
[
[
1010,
63,
1428
],
[
1428,
1,
376
]
],
[
[
1010,
24,
409
],
[
409,
1,
376
]
],
[
[
1010,
24,
1081
],
[
1081,
... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amlodipine"
]
],
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isradipine"
],
[
... | Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradipine (Compound) resembles Amlodipine (Compound)
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Felodipine and Felodipine (Compound) resembles Amlodipine (Compound)
... |
DB01177 | DB11601 | 77 | 1,270 | [
"DDInter904",
"DDInter1889"
] | Idarubicin | Tuberculin purified protein derivative | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The diagnostic test is commonly referred to as the Mantoux test which serves to minimize the risk of transmission of infection with *Mycoba... | Moderate | 1 | [
[
[
77,
24,
1270
]
],
[
[
77,
64,
550
],
[
550,
24,
1270
]
],
[
[
77,
24,
1531
],
[
1531,
24,
1270
]
],
[
[
77,
63,
869
],
[
869,
24... | [
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protein derivative"
]
],
[
[
"Idarubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trastuzumab"
... | Idarubicin may lead to a major life threatening interaction when taken with Trastuzumab and Trastuzumab may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative
Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Canaki... |
DB06605 | DB14006 | 1,409 | 972 | [
"DDInter108",
"DDInter370"
] | Apixaban | Choline salicylate | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Choline salicylate is an anti-inflammatory pain reliever agent that is related to aspirin. It is used to decrease swelling and to treat mild-moderate pain. It is used to treat arthritis in both children and adults. This medicine can also be used for fever . Choline Salicylate is the choline salt of salicylic acid, used... | Moderate | 1 | [
[
[
1409,
24,
972
]
],
[
[
1409,
64,
553
],
[
553,
24,
972
]
],
[
[
1409,
63,
1039
],
[
1039,
24,
972
]
],
[
[
1409,
24,
1074
],
[
1074,
... | [
[
[
"Apixaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Choline salicylate"
]
],
[
[
"Apixaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fondaparinux"
],
[
"Fond... | Apixaban may lead to a major life threatening interaction when taken with Fondaparinux and Fondaparinux may cause a moderate interaction that could exacerbate diseases when taken with Choline salicylate
Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine and Dexfenfl... |
DB00317 | DB00701 | 883 | 1,091 | [
"DDInter810",
"DDInter90"
] | Gefitinib | Amprenavir | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | Amprenavir is a protease inhibitor used to treat HIV infection. | Moderate | 1 | [
[
[
883,
24,
1091
]
],
[
[
883,
24,
34
],
[
34,
1,
1091
]
],
[
[
883,
6,
4973
],
[
4973,
45,
1091
]
],
[
[
883,
21,
28810
],
[
28810,
... | [
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amprenavir"
]
],
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosamprenavir"
],
[
... | Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Fosamprenavir and Fosamprenavir (Compound) resembles Amprenavir (Compound)
Gefitinib (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Amprenavir (Compound)
Gefitinib (Compound) causes Gastrointestinal pain (Side Effect) ... |
DB01069 | DB01168 | 401 | 1,053 | [
"DDInter1533",
"DDInter1526"
] | Promethazine | Procarbazine | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Moderate | 1 | [
[
[
401,
24,
1053
]
],
[
[
401,
21,
28762
],
[
28762,
60,
1053
]
],
[
[
401,
64,
246
],
[
246,
23,
1053
]
],
[
[
401,
63,
739
],
[
739,
... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
]
],
[
[
"Promethazine",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is ... | Promethazine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Procarbazine (Compound)
Promethazine may lead to a major life threatening interaction when taken with Gatifloxacin and Gatifloxacin may cause a minor interaction that can limit clinical effects when taken with Procarbazine
Pro... |
DB08820 | DB11901 | 1,478 | 913 | [
"DDInter997",
"DDInter107"
] | Ivacaftor | Apalutamide | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Major | 2 | [
[
[
1478,
25,
913
]
],
[
[
1478,
63,
312
],
[
312,
23,
913
]
],
[
[
1478,
23,
271
],
[
271,
23,
913
]
],
[
[
1478,
24,
110
],
[
110,
... | [
[
[
"Ivacaftor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apalutamide"
]
],
[
[
"Ivacaftor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eplerenone"
],
[
"Eplerenone"... | Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Eplerenone and Eplerenone may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Ivacaftor may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron ... |
DB01157 | DB08827 | 304 | 990 | [
"DDInter1875",
"DDInter1085"
] | Trimetrexate | Lomitapide | A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against pneumocystis pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect. | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Major | 2 | [
[
[
304,
25,
990
]
],
[
[
304,
21,
28658
],
[
28658,
60,
990
]
],
[
[
304,
24,
1362
],
[
1362,
63,
990
]
],
[
[
304,
62,
752
],
[
752,
... | [
[
[
"Trimetrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomitapide"
]
],
[
[
"Trimetrexate",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Effect) is caused by {v} (Co... | Trimetrexate (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Lomitapide (Compound)
Trimetrexate may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Lomitapid... |
DB00857 | DB01238 | 1,387 | 673 | [
"DDInter1768",
"DDInter118"
] | Terbinafine | Aripiprazole | Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epox... | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Moderate | 1 | [
[
[
1387,
24,
673
]
],
[
[
1387,
63,
827
],
[
827,
40,
673
]
],
[
[
1387,
63,
1630
],
[
1630,
1,
673
]
],
[
[
1387,
6,
12523
],
[
12523,
... | [
[
[
"Terbinafine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aripiprazole"
]
],
[
[
"Terbinafine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trazodone"
],
[... | Terbinafine may cause a moderate interaction that could exacerbate diseases when taken with Trazodone and Trazodone (Compound) resembles Aripiprazole (Compound)
Terbinafine may cause a moderate interaction that could exacerbate diseases when taken with Perphenazine and Perphenazine (Compound) resembles Aripiprazole (Co... |
DB00307 | DB13928 | 1,101 | 1,385 | [
"DDInter202",
"DDInter1660"
] | Bexarotene | Semaglutide | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. Semaglutide was developed by Novo Nordisk and approved ... | Major | 2 | [
[
[
1101,
25,
1385
]
],
[
[
1101,
23,
839
],
[
839,
24,
1385
]
],
[
[
1101,
25,
637
],
[
637,
24,
1385
]
],
[
[
1101,
24,
891
],
[
891,
... | [
[
[
"Bexarotene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Semaglutide"
]
],
[
[
"Bexarotene",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Grepafloxacin"
],
[
"Grepaflo... | Bexarotene may cause a minor interaction that can limit clinical effects when taken with Grepafloxacin and Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide
Bexarotene may lead to a major life threatening interaction when taken with Asparaginase Erwinia chrysanthe... |
DB01076 | DB01611 | 700 | 1,487 | [
"DDInter133",
"DDInter893"
] | Atorvastatin | Hydroxychloroquine | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Moderate | 1 | [
[
[
700,
24,
1487
]
],
[
[
700,
6,
12523
],
[
12523,
45,
1487
]
],
[
[
700,
63,
663
],
[
663,
23,
1487
]
],
[
[
700,
63,
723
],
[
723,
... | [
[
[
"Atorvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Atorvastatin",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} ... | Atorvastatin (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Hydroxychloroquine (Compound)
Atorvastatin may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a minor interaction that can limit clinical effects when taken with Hydroxychloroqu... |
DB00656 | DB01177 | 827 | 77 | [
"DDInter1851",
"DDInter904"
] | Trazodone | Idarubicin | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Moderate | 1 | [
[
[
827,
24,
77
]
],
[
[
827,
6,
12523
],
[
12523,
45,
77
]
],
[
[
827,
21,
29170
],
[
29170,
60,
77
]
],
[
[
827,
23,
112
],
[
112,
... | [
[
[
"Trazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idarubicin"
]
],
[
[
"Trazodone",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
... | Trazodone (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Idarubicin (Compound)
Trazodone (Compound) causes Cardiac failure congestive (Side Effect) and Cardiac failure congestive (Side Effect) is caused by Idarubicin (Compound)
Trazodone may cause a minor interaction that can limit clinical effects when t... |
DB00945 | DB01136 | 1,479 | 772 | [
"DDInter20",
"DDInter305"
] | Acetylsalicylic acid | Carvedilol | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Minor | 0 | [
[
[
1479,
23,
772
]
],
[
[
1479,
6,
4973
],
[
4973,
45,
772
]
],
[
[
1479,
21,
28789
],
[
28789,
60,
772
]
],
[
[
1479,
24,
1283
],
[
1283... | [
[
[
"Acetylsalicylic acid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Carvedilol"
]
],
[
[
"Acetylsalicylic acid",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by ... | Acetylsalicylic acid (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Carvedilol (Compound)
Acetylsalicylic acid (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Carvedilol (Compound)
Acetylsalicylic acid may cause a moderate interaction that could exa... |
DB00662 | DB09118 | 717 | 1,580 | [
"DDInter1873",
"DDInter1711"
] | Trimethobenzamide | Stiripentol | Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against e... | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Moderate | 1 | [
[
[
717,
24,
1580
]
],
[
[
717,
24,
1532
],
[
1532,
24,
1580
]
],
[
[
717,
24,
1609
],
[
1609,
63,
1580
]
],
[
[
717,
63,
128
],
[
128,
... | [
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stiripentol"
]
],
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
... | Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol
Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Pentox... |
DB06282 | DB11823 | 516 | 858 | [
"DDInter1053",
"DDInter673"
] | Levocetirizine | Esketamine | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Major depressive disorder (MDD) is a significant cause of disability worldwide and the most common illness preceding suicide.[L5596,A175462] On March 5, 2019, the nasal spray drug, _esketamine_, also known as _Spravato_ (by Janssen Pharmaceuticals), was approved by the FDA for treatment-resistant major depression. Eske... | Moderate | 1 | [
[
[
516,
24,
858
]
],
[
[
516,
63,
272
],
[
272,
24,
858
]
],
[
[
516,
24,
849
],
[
849,
24,
858
]
],
[
[
516,
63,
272
],
[
272,
63,... | [
[
[
"Levocetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esketamine"
]
],
[
[
"Levocetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
... | Levocetirizine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Esketamine
Levocetirizine may cause a moderate interaction that could exacerbate diseases when taken with M... |
DB00622 | DB01041 | 1,081 | 770 | [
"DDInter1287",
"DDInter1789"
] | Nicardipine | Thalidomide | A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [Pub... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
1081,
24,
770
]
],
[
[
1081,
6,
6365
],
[
6365,
45,
770
]
],
[
[
1081,
21,
28789
],
[
28789,
60,
770
]
],
[
[
1081,
24,
849
],
[
849,
... | [
[
[
"Nicardipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Nicardipine",
"{u} (Compound) binds {v} (Gene)",
"CYP2E1"
],
[
"CYP2E1",
"{u} (Gene) is bound by {v} (Compound... | Nicardipine (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Thalidomide (Compound)
Nicardipine (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Thalidomide (Compound)
Nicardipine may cause a moderate interaction that could exacerbate diseases when t... |
DB01132 | DB02701 | 1,130 | 1,632 | [
"DDInter1472",
"DDInter1289"
] | Pioglitazone | Nicotinamide | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and pellagra. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake. | Moderate | 1 | [
[
[
1130,
24,
1632
]
],
[
[
1130,
63,
1236
],
[
1236,
23,
1632
]
],
[
[
1130,
24,
1254
],
[
1254,
24,
1632
]
],
[
[
1130,
63,
176
],
[
176... | [
[
[
"Pioglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nicotinamide"
]
],
[
[
"Pioglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbamazepine"
],... | Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Carbamazepine and Carbamazepine may cause a minor interaction that can limit clinical effects when taken with Nicotinamide
Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Insulin glu... |
DB00773 | DB10429 | 896 | 200 | [
"DDInter702",
"DDInter282"
] | Etoposide | Candida albicans | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Moderate | 1 | [
[
[
896,
24,
200
]
],
[
[
896,
24,
1683
],
[
1683,
24,
200
]
],
[
[
896,
25,
976
],
[
976,
24,
200
]
],
[
[
896,
63,
168
],
[
168,
2... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
]
],
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
],
... | Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans
Etoposide may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib ma... |
DB00543 | DB00604 | 87 | 1,425 | [
"DDInter82",
"DDInter385"
] | Amoxapine | Cisapride | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Major | 2 | [
[
[
87,
25,
1425
]
],
[
[
87,
25,
1311
],
[
1311,
1,
1425
]
],
[
[
87,
24,
717
],
[
717,
1,
1425
]
],
[
[
87,
6,
6962
],
[
6962,
45,... | [
[
[
"Amoxapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cisapride"
]
],
[
[
"Amoxapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Metoclopramide"
],
[
"Metoclopramide",
"... | Amoxapine may lead to a major life threatening interaction when taken with Metoclopramide and Metoclopramide (Compound) resembles Cisapride (Compound)
Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Trimethobenzamide and Trimethobenzamide (Compound) resembles Cisapride (Compoun... |
DB04845 | DB08868 | 309 | 1,011 | [
"DDInter1001",
"DDInter737"
] | Ixabepilone | Fingolimod | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
309,
25,
1011
]
],
[
[
309,
6,
8374
],
[
8374,
45,
1011
]
],
[
[
309,
21,
28792
],
[
28792,
60,
1011
]
],
[
[
309,
63,
112
],
[
112,
... | [
[
[
"Ixabepilone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Ixabepilone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Fingo... | Ixabepilone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fingolimod (Compound)
Ixabepilone (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Fingolimod (Compound)
Ixabepilone may cause a moderate interaction that could exacerbate diseases ... |
DB00681 | DB00687 | 1,287 | 870 | [
"DDInter85",
"DDInter747"
] | Amphotericin B | Fludrocortisone | Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphot... | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Moderate | 1 | [
[
[
1287,
24,
870
]
],
[
[
1287,
24,
1220
],
[
1220,
40,
870
]
],
[
[
1287,
63,
251
],
[
251,
40,
870
]
],
[
[
1287,
21,
28835
],
[
28835,... | [
[
[
"Amphotericin B",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
]
],
[
[
"Amphotericin B",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"... | Amphotericin B may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Fludrocortisone (Compound)
Amphotericin B may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone (Compound) resembl... |
DB00515 | DB01235 | 589 | 1,191 | [
"DDInter387",
"DDInter1054"
] | Cisplatin | Levodopa | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prev... | Moderate | 1 | [
[
[
589,
24,
1191
]
],
[
[
589,
24,
1307
],
[
1307,
40,
1191
]
],
[
[
589,
21,
28936
],
[
28936,
60,
1191
]
],
[
[
589,
63,
63
],
[
63,
... | [
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levodopa"
]
],
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Melphalan"
],
[
"... | Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Melphalan and Melphalan (Compound) resembles Levodopa (Compound)
Cisplatin (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Levodopa (Compound)
Cisplatin may cause a moderate interaction t... |
DB01320 | DB09564 | 651 | 1,296 | [
"DDInter783",
"DDInter930"
] | Fosphenytoin | Insulin degludec | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
651,
24,
1296
]
],
[
[
651,
63,
1411
],
[
1411,
24,
1296
]
],
[
[
651,
64,
1151
],
[
1151,
24,
1296
]
],
[
[
651,
24,
761
],
[
761,
... | [
[
[
"Fosphenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Fosphenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
... | Fosphenytoin may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Fosphenytoin may lead to a major life threatening interaction when taken with Sunitinib and Sunitinib ... |
DB01114 | DB01320 | 272 | 651 | [
"DDInter362",
"DDInter783"
] | Chlorpheniramine | Fosphenytoin | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Moderate | 1 | [
[
[
272,
24,
651
]
],
[
[
272,
63,
362
],
[
362,
1,
651
]
],
[
[
272,
6,
8374
],
[
8374,
45,
651
]
],
[
[
272,
21,
28691
],
[
28691,
... | [
[
[
"Chlorpheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Chlorpheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
... | Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Compound)
Chlorpheniramine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fosphenytoin (Compound)
Chlorpheniramine (Compound) causes Somnolence (Side ... |
DB01075 | DB11915 | 1,376 | 1,293 | [
"DDInter569",
"DDInter1909"
] | Diphenhydramine | Valbenazine | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Moderate | 1 | [
[
[
1376,
24,
1293
]
],
[
[
1376,
24,
516
],
[
516,
24,
1293
]
],
[
[
1376,
63,
401
],
[
401,
24,
1293
]
],
[
[
1376,
24,
283
],
[
283,
... | [
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valbenazine"
]
],
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
... | Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine and Levocetirizine may cause a moderate interaction that could exacerbate diseases when taken with Valbenazine
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Pr... |
DB00580 | DB14723 | 311 | 159 | [
"DDInter1910",
"DDInter1026"
] | Valdecoxib | Larotrectinib | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
311,
24,
159
]
],
[
[
311,
24,
267
],
[
267,
24,
159
]
],
[
[
311,
63,
912
],
[
912,
24,
159
]
],
[
[
311,
25,
629
],
[
629,
24,... | [
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
],
[... | Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib
Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Interferon beta-1a... |
DB08816 | DB14357 | 578 | 944 | [
"DDInter1802",
"DDInter347"
] | Ticagrelor | Chamomile | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Chamomile is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. | Minor | 0 | [
[
[
578,
23,
944
]
],
[
[
578,
63,
256
],
[
256,
23,
944
]
],
[
[
578,
64,
792
],
[
792,
23,
944
]
],
[
[
578,
25,
498
],
[
498,
23,... | [
[
[
"Ticagrelor",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
]
],
[
[
"Ticagrelor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prasugrel"
],
[
... | Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Prasugrel and Prasugrel may cause a minor interaction that can limit clinical effects when taken with Chamomile
Ticagrelor may lead to a major life threatening interaction when taken with Rivaroxaban and Rivaroxaban may cause a m... |
DB06674 | DB06810 | 908 | 397 | [
"DDInter837",
"DDInter1484"
] | Golimumab | Plicamycin | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Plicamycin is an antineoplastic antibiotic produced by Streptomyces plicatus. It has been used in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of hypercalcemia. The manufacturer discontinued plicamycin in 2000. | Major | 2 | [
[
[
908,
25,
397
]
],
[
[
908,
63,
597
],
[
597,
24,
397
]
],
[
[
908,
24,
151
],
[
151,
63,
397
]
],
[
[
908,
64,
248
],
[
248,
24,... | [
[
[
"Golimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Plicamycin"
]
],
[
[
"Golimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphenicol"
],
[
"Chloram... | Golimumab may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Plicamycin
Golimumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A v... |
DB00910 | DB01174 | 1,041 | 697 | [
"DDInter1394",
"DDInter1442"
] | Paricalcitol | Phenobarbital | Paricalcitol is a synthetic vitamin D analog. Paricalcitol has been used to reduce parathyroid hormone levels. Paricalcitol is indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure. | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Moderate | 1 | [
[
[
1041,
24,
697
]
],
[
[
1041,
63,
759
],
[
759,
1,
697
]
],
[
[
1041,
63,
536
],
[
536,
40,
697
]
],
[
[
1041,
6,
8374
],
[
8374,
... | [
[
[
"Paricalcitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenobarbital"
]
],
[
[
"Paricalcitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
],
... | Paricalcitol may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone (Compound) resembles Phenobarbital (Compound)
Paricalcitol may cause a moderate interaction that could exacerbate diseases when taken with Secobarbital and Secobarbital (Compound) resembles Phenobarbital... |
DB00532 | DB00620 | 208 | 175 | [
"DDInter1152",
"DDInter1855"
] | Mephenytoin | Triamcinolone | Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subuni... | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Moderate | 1 | [
[
[
208,
24,
175
]
],
[
[
208,
24,
1573
],
[
1573,
1,
175
]
],
[
[
208,
63,
251
],
[
251,
1,
175
]
],
[
[
208,
63,
1018
],
[
1018,
2... | [
[
[
"Mephenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
]
],
[
[
"Mephenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
],
... | Mephenytoin may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone (Compound) resembles Triamcinolone (Compound)
Mephenytoin may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone (Compound) resembles Triamcinolo... |
DB00065 | DB08885 | 581 | 363 | [
"DDInter923",
"DDInter33"
] | Infliximab | Aflibercept | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Aflibercept is a recombinant protein composed of the binding domains of two human vascular endothelial growth factor (VEGF) receptors, VEGFR1 and VEGFR2, fused with the Fc region of human immunoglobulin gamma 1 (IgG1). Structurally, Aflibercept is a dimeric glycoprotein with a protein molecular weight of 96.9 kilo Dalt... | Major | 2 | [
[
[
581,
25,
363
]
],
[
[
581,
25,
1531
],
[
1531,
24,
363
]
],
[
[
581,
24,
151
],
[
151,
63,
363
]
],
[
[
581,
24,
58
],
[
58,
24,... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Aflibercept"
]
],
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Canakinumab"
],
[
"Canakinumab",
"{u... | Infliximab may lead to a major life threatening interaction when taken with Canakinumab and Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Aflibercept
Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/... |
DB01041 | DB10989 | 770 | 496 | [
"DDInter1789",
"DDInter858"
] | Thalidomide | Hepatitis A Vaccine | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure. Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infectio... | Moderate | 1 | [
[
[
770,
24,
496
]
],
[
[
770,
24,
4
],
[
4,
24,
496
]
],
[
[
770,
64,
147
],
[
147,
24,
496
]
],
[
[
770,
24,
738
],
[
738,
63,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepe... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine
Thalidomide may lead to a major life threatening interaction when taken ... |
DB00569 | DB12364 | 553 | 1,421 | [
"DDInter775",
"DDInter200"
] | Fondaparinux | Betrixaban | Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in he... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Major | 2 | [
[
[
553,
25,
1421
]
],
[
[
553,
23,
297
],
[
297,
23,
1421
]
],
[
[
553,
23,
1631
],
[
1631,
62,
1421
]
],
[
[
553,
24,
992
],
[
992,
... | [
[
[
"Fondaparinux",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betrixaban"
]
],
[
[
"Fondaparinux",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clove",
... | Fondaparinux may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Betrixaban
Fondaparinux may cause a minor interaction that can limit clinical effects when taken with Turmeric and Turmeric may cause a... |
DB00959 | DB06674 | 1,486 | 908 | [
"DDInter1191",
"DDInter837"
] | Methylprednisolone | Golimumab | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Major | 2 | [
[
[
1486,
25,
908
]
],
[
[
1486,
23,
1193
],
[
1193,
62,
908
]
],
[
[
1486,
62,
1461
],
[
1461,
23,
908
]
],
[
[
1486,
24,
336
],
[
336,
... | [
[
[
"Methylprednisolone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Golimumab"
]
],
[
[
"Methylprednisolone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
... | Methylprednisolone may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Golimumab
Methylprednisolone may cause a minor interaction that can limit clinical effects when taken with Vita... |
DB00400 | DB09039 | 353 | 1,670 | [
"DDInter843",
"DDInter629"
] | Griseofulvin | Eliglustat | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Moderate | 1 | [
[
[
353,
24,
1670
]
],
[
[
353,
24,
479
],
[
479,
23,
1670
]
],
[
[
353,
24,
1135
],
[
1135,
62,
1670
]
],
[
[
353,
24,
1409
],
[
1409,
... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eliglustat"
]
],
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
],
[... | Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepezil may cause a minor interaction that can limit clinical effects when taken with Eliglustat
Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxeg... |
DB00333 | DB08881 | 576 | 868 | [
"DDInter1166",
"DDInter1925"
] | Methadone | Vemurafenib | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Major | 2 | [
[
[
576,
25,
868
]
],
[
[
576,
6,
8374
],
[
8374,
45,
868
]
],
[
[
576,
21,
28714
],
[
28714,
60,
868
]
],
[
[
576,
23,
112
],
[
112,
... | [
[
[
"Methadone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
]
],
[
[
"Methadone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Vemurafe... | Methadone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vemurafenib (Compound)
Methadone (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Vemurafenib (Compound)
Methadone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metron... |
DB00451 | DB06718 | 542 | 1,687 | [
"DDInter1064",
"DDInter1709"
] | Levothyroxine | Stanozolol | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Stanozolol is a synthetic anabolic steroid with therapeutic uses in treating hereditary angioedema. Stanozolol is derived from testosterone, and has been abused by several high profile professional athletes. | Moderate | 1 | [
[
[
542,
24,
1687
]
],
[
[
542,
24,
1546
],
[
1546,
1,
1687
]
],
[
[
542,
24,
1561
],
[
1561,
40,
1687
]
],
[
[
542,
7,
7273
],
[
7273,
... | [
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stanozolol"
]
],
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyltestosterone"
... | Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Methyltestosterone and Methyltestosterone (Compound) resembles Stanozolol (Compound)
Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Testosterone and Testosterone (Compound) resemb... |
DB00242 | DB15035 | 1,064 | 503 | [
"DDInter392",
"DDInter1959"
] | Cladribine | Zanubrutinib | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Major | 2 | [
[
[
1064,
25,
503
]
],
[
[
1064,
25,
810
],
[
810,
24,
503
]
],
[
[
1064,
64,
66
],
[
66,
24,
503
]
],
[
[
1064,
24,
869
],
[
869,
2... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Strontium chloride Sr-89"
],
[
"Strontium... | Cladribine may lead to a major life threatening interaction when taken with Strontium chloride Sr-89 and Strontium chloride Sr-89 may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Cladribine may lead to a major life threatening interaction when taken with Efalizumab and Efaliz... |
DB00106 | DB00543 | 618 | 87 | [
"DDInter4",
"DDInter82"
] | Abarelix | Amoxapine | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | Moderate | 1 | [
[
[
618,
24,
87
]
],
[
[
618,
24,
623
],
[
623,
40,
87
]
],
[
[
618,
25,
695
],
[
695,
40,
87
]
],
[
[
618,
24,
867
],
[
867,
1,
... | [
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amoxapine"
]
],
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quetiapine"
],
[
"... | Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Quetiapine and Quetiapine (Compound) resembles Amoxapine (Compound)
Abarelix may lead to a major life threatening interaction when taken with Clozapine and Clozapine (Compound) resembles Amoxapine (Compound)
Abarelix may cause a mo... |
DB00308 | DB00889 | 347 | 1,133 | [
"DDInter901",
"DDInter840"
] | Ibutilide | Granisetron | Ibutilide is a Class III antiarrhythmic agent available in intravenous formulations. It is indicated for the conversion of acute atrial flutter and recent onset atrial fibrillation to normal sinus rhythm (NSR). | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Major | 2 | [
[
[
347,
25,
1133
]
],
[
[
347,
21,
29024
],
[
29024,
60,
1133
]
],
[
[
347,
23,
112
],
[
112,
62,
1133
]
],
[
[
347,
25,
1213
],
[
1213,
... | [
[
[
"Ibutilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Granisetron"
]
],
[
[
"Ibutilide",
"{u} (Compound) causes {v} (Side Effect)",
"Hypertension"
],
[
"Hypertension",
"{u} (Side Effect) is caused by {v} ... | Ibutilide (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Granisetron (Compound)
Ibutilide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with ... |
DB00909 | DB01142 | 306 | 1,264 | [
"DDInter1971",
"DDInter593"
] | Zonisamide | Doxepin | Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. This... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Major | 2 | [
[
[
306,
25,
1264
]
],
[
[
306,
25,
401
],
[
401,
24,
1264
]
],
[
[
306,
64,
832
],
[
832,
24,
1264
]
],
[
[
306,
24,
649
],
[
649,
... | [
[
[
"Zonisamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Doxepin"
]
],
[
[
"Zonisamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Promethazine"
],
[
"Promethazine",
"{u} ... | Zonisamide may lead to a major life threatening interaction when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Zonisamide may lead to a major life threatening interaction when taken with Tripelennamine and Tripelennamine may cause a mode... |
DB00263 | DB00704 | 1,029 | 267 | [
"DDInter1727",
"DDInter1263"
] | Sulfisoxazole | Naltrexone | A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms. | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Moderate | 1 | [
[
[
1029,
24,
267
]
],
[
[
1029,
18,
6797
],
[
6797,
57,
267
]
],
[
[
1029,
24,
850
],
[
850,
63,
267
]
],
[
[
1029,
40,
698
],
[
698,
... | [
[
[
"Sulfisoxazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
]
],
[
[
"Sulfisoxazole",
"{u} (Compound) downregulates {v} (Gene)",
"CYCS"
],
[
"CYCS",
"{u} (Gene) is downregulated b... | Sulfisoxazole (Compound) downregulates CYCS (Gene) and CYCS (Gene) is downregulated by Naltrexone (Compound)
Sulfisoxazole may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin and Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when take... |
DB00497 | DB11979 | 828 | 1,320 | [
"DDInter1366",
"DDInter625"
] | Oxycodone | Elagolix | Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.[Label] The f... | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Major | 2 | [
[
[
828,
25,
1320
]
],
[
[
828,
24,
1297
],
[
1297,
24,
1320
]
],
[
[
828,
25,
129
],
[
129,
24,
1320
]
],
[
[
828,
64,
597
],
[
597,
... | [
[
[
"Oxycodone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Elagolix"
]
],
[
[
"Oxycodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
],
[
"Osilodrostat... | Oxycodone may cause a moderate interaction that could exacerbate diseases when taken with Osilodrostat and Osilodrostat may cause a moderate interaction that could exacerbate diseases when taken with Elagolix
Oxycodone may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide may ca... |
DB00810 | DB09272 | 456 | 412 | [
"DDInter211",
"DDInter632"
] | Biperiden | Eluxadoline | A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine. | Eluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D). The mu-, kappa-, and delta-opioid receptors mediate endogenous and exogenous opioid response in the central nervous system ... | Moderate | 1 | [
[
[
456,
24,
412
]
],
[
[
456,
63,
1594
],
[
1594,
24,
412
]
],
[
[
456,
1,
1105
],
[
1105,
24,
412
]
],
[
[
456,
24,
543
],
[
543,
... | [
[
[
"Biperiden",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eluxadoline"
]
],
[
[
"Biperiden",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[
... | Biperiden may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Eluxadoline
Biperiden (Compound) resembles Trihexyphenidyl (Compound) and Trihexyphenidyl may cause a moderate interaction t... |
DB00295 | DB00321 | 475 | 21 | [
"DDInter1244",
"DDInter78"
] | Morphine | Amitriptyline | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Moderate | 1 | [
[
[
475,
24,
21
]
],
[
[
475,
24,
649
],
[
649,
63,
21
]
],
[
[
475,
24,
1237
],
[
1237,
40,
21
]
],
[
[
475,
24,
1164
],
[
1164,
1,... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amitriptyline"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],
[
... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Amitriptyline
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomi... |
DB06402 | DB06663 | 1,079 | 1,154 | [
"DDInter1756",
"DDInter1398"
] | Telavancin | Pasireotide | Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria. MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and skin and sub... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
1079,
25,
1154
]
],
[
[
1079,
21,
28658
],
[
28658,
60,
1154
]
],
[
[
1079,
62,
112
],
[
112,
23,
1154
]
],
[
[
1079,
24,
1662
],
[
16... | [
[
[
"Telavancin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Telavancin",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Effect) is caused by {v} (Compo... | Telavancin (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Pasireotide (Compound)
Telavancin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pasire... |
DB00364 | DB00467 | 417 | 1,467 | [
"DDInter1717",
"DDInter644"
] | Sucralfate | Enoxacin | Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia. It is considered a _cytoprotective agent_, protect... | A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. | Moderate | 1 | [
[
[
417,
24,
1467
]
],
[
[
417,
24,
1539
],
[
1539,
40,
1467
]
],
[
[
417,
24,
1299
],
[
1299,
1,
1467
]
],
[
[
417,
63,
1176
],
[
1176,
... | [
[
[
"Sucralfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enoxacin"
]
],
[
[
"Sucralfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ofloxacin"
],
[
... | Sucralfate may cause a moderate interaction that could exacerbate diseases when taken with Ofloxacin and Ofloxacin (Compound) resembles Enoxacin (Compound)
Sucralfate may cause a moderate interaction that could exacerbate diseases when taken with Trovafloxacin and Trovafloxacin (Compound) resembles Enoxacin (Compound)
... |
DB00865 | DB08907 | 939 | 1,344 | [
"DDInter187",
"DDInter280"
] | Benzphetamine | Canagliflozin | A sympathomimetic agent with properties similar to dextroamphetamine. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222) | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
939,
24,
1344
]
],
[
[
939,
24,
549
],
[
549,
1,
1344
]
],
[
[
939,
6,
8374
],
[
8374,
45,
1344
]
],
[
[
939,
21,
28681
],
[
28681,
... | [
[
[
"Benzphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Benzphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
... | Benzphetamine may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Benzphetamine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Canagliflozin (Compound)
Benzphetamine (Compound) causes Hypersensitivity... |
DB00443 | DB00461 | 251 | 598 | [
"DDInter195",
"DDInter1254"
] | Betamethasone | Nabumetone | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a de... | Moderate | 1 | [
[
[
251,
24,
598
]
],
[
[
251,
6,
7720
],
[
7720,
45,
598
]
],
[
[
251,
5,
11577
],
[
11577,
49,
598
]
],
[
[
251,
18,
3106
],
[
3106,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabumetone"
]
],
[
[
"Betamethasone",
"{u} (Compound) binds {v} (Gene)",
"PTGS2"
],
[
"PTGS2",
"{u} (Gene) is bound by {v} (Compoun... | Betamethasone (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Nabumetone (Compound)
Betamethasone (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is palliated by Nabumetone (Compound)
Betamethasone (Compound) downregulates DNAJA3 (Gene) and DNAJA3 (Gene) is downregulated b... |
DB01261 | DB09098 | 170 | 98 | [
"DDInter1679",
"DDInter1700"
] | Sitagliptin | Somatrem | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
170,
24,
98
]
],
[
[
170,
63,
168
],
[
168,
23,
98
]
],
[
[
170,
24,
1671
],
[
1671,
24,
98
]
],
[
[
170,
63,
1573
],
[
1573,
24... | [
[
[
"Sitagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Sitagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Somatrem
Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Flibanserin and Flibans... |
DB00532 | DB01611 | 208 | 1,487 | [
"DDInter1152",
"DDInter893"
] | Mephenytoin | Hydroxychloroquine | Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subuni... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Moderate | 1 | [
[
[
208,
24,
1487
]
],
[
[
208,
24,
663
],
[
663,
23,
1487
]
],
[
[
208,
62,
168
],
[
168,
24,
1487
]
],
[
[
208,
63,
597
],
[
597,
... | [
[
[
"Mephenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Mephenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
... | Mephenytoin may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a minor interaction that can limit clinical effects when taken with Hydroxychloroquine
Mephenytoin may cause a minor interaction that can limit clinical effects when taken with Bortezomib ... |
DB01236 | DB08881 | 679 | 868 | [
"DDInter1664",
"DDInter1925"
] | Sevoflurane | Vemurafenib | Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 199... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Major | 2 | [
[
[
679,
25,
868
]
],
[
[
679,
6,
8374
],
[
8374,
45,
868
]
],
[
[
679,
21,
28714
],
[
28714,
60,
868
]
],
[
[
679,
62,
112
],
[
112,
... | [
[
[
"Sevoflurane",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
]
],
[
[
"Sevoflurane",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Vemu... | Sevoflurane (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vemurafenib (Compound)
Sevoflurane (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Vemurafenib (Compound)
Sevoflurane may cause a minor interaction that can limit clinical effects when taken with Metronidazole and ... |
DB04953 | DB09020 | 495 | 28 | [
"DDInter708",
"DDInter212"
] | Ezogabine | Bisacodyl | Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients wi... | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
495,
24,
28
]
],
[
[
495,
63,
662
],
[
662,
1,
28
]
],
[
[
495,
63,
128
],
[
128,
40,
28
]
],
[
[
495,
21,
28666
],
[
28666,
60,... | [
[
[
"Ezogabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Ezogabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
[
... | Ezogabine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine (Compound) resembles Bisacodyl (Compound)
Ezogabine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine and Dexbrompheniramine (Compound) resembles Bis... |
DB06674 | DB14444 | 908 | 151 | [
"DDInter837",
"DDInter924"
] | Golimumab | Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immuno... | Moderate | 1 | [
[
[
908,
24,
151
]
],
[
[
908,
63,
66
],
[
66,
24,
151
]
],
[
[
908,
64,
134
],
[
134,
24,
151
]
],
[
[
908,
25,
1619
],
[
1619,
24,... | [
[
[
"Golimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)"
]
],
[
[
"Golimumab",
"{u} may cause a moderate interaction that could exa... | Golimumab may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Golimumab may lead to a major life thr... |
DB00279 | DB06707 | 1,152 | 584 | [
"DDInter1074",
"DDInter1060"
] | Liothyronine | Levonordefrin | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | Levonordefrin acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry. | Moderate | 1 | [
[
[
1152,
24,
584
]
],
[
[
1152,
1,
1191
],
[
1191,
40,
584
]
],
[
[
1152,
24,
817
],
[
817,
40,
584
]
],
[
[
1152,
63,
73
],
[
73,
... | [
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levonordefrin"
]
],
[
[
"Liothyronine",
"{u} (Compound) resembles {v} (Compound)",
"Levodopa"
],
[
"Levodopa",
"{u} (Compound) resem... | Liothyronine (Compound) resembles Levodopa (Compound) and Levodopa (Compound) resembles Levonordefrin (Compound)
Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Dopamine and Dopamine (Compound) resembles Levonordefrin (Compound)
Liothyronine may cause a moderate interaction ... |
DB00631 | DB06168 | 372 | 1,531 | [
"DDInter405",
"DDInter281"
] | Clofarabine | Canakinumab | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Moderate | 1 | [
[
[
372,
24,
1531
]
],
[
[
372,
63,
1461
],
[
1461,
23,
1531
]
],
[
[
372,
63,
377
],
[
377,
24,
1531
]
],
[
[
372,
24,
1270
],
[
1270,
... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Canakinumab
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Mitomycin and Mitomyci... |
DB06700 | DB08824 | 643 | 591 | [
"DDInter511",
"DDInter959"
] | Desvenlafaxine | Ioflupane I-123 | Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of ad... | Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes. | Moderate | 1 | [
[
[
643,
24,
591
]
],
[
[
643,
21,
29305
],
[
29305,
60,
591
]
],
[
[
643,
63,
401
],
[
401,
24,
591
]
],
[
[
643,
40,
1100
],
[
1100,
... | [
[
[
"Desvenlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioflupane I-123"
]
],
[
[
"Desvenlafaxine",
"{u} (Compound) causes {v} (Side Effect)",
"Dysgeusia"
],
[
"Dysgeusia",
"{u} (Side Ef... | Desvenlafaxine (Compound) causes Dysgeusia (Side Effect) and Dysgeusia (Side Effect) is caused by Ioflupane I-123 (Compound)
Desvenlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when t... |
DB06699 | DB12245 | 774 | 823 | [
"DDInter493",
"DDInter1863"
] | Degarelix | Triclabendazole | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
774,
24,
823
]
],
[
[
774,
62,
1247
],
[
1247,
23,
823
]
],
[
[
774,
24,
1612
],
[
1612,
24,
823
]
],
[
[
774,
63,
1010
],
[
1010,
... | [
[
[
"Degarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Degarelix",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Degarelix may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Degarelix may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavi... |
DB00976 | DB00983 | 1,056 | 480 | [
"DDInter1758",
"DDInter776"
] | Telithromycin | Formoterol | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Moderate | 1 | [
[
[
1056,
24,
480
]
],
[
[
1056,
24,
1148
],
[
1148,
63,
480
]
],
[
[
1056,
6,
12523
],
[
12523,
45,
480
]
],
[
[
1056,
21,
28963
],
[
289... | [
[
[
"Telithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
]
],
[
[
"Telithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
... | Telithromycin may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Formoterol
Telithromycin (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Formoterol (Compound)
Telithro... |
DB00224 | DB01410 | 215 | 423 | [
"DDInter917",
"DDInter376"
] | Indinavir | Ciclesonide (nasal) | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem] | Ciclesonide is an organic molecular entity. | Moderate | 1 | [
[
[
215,
24,
423
]
],
[
[
215,
24,
1573
],
[
1573,
1,
423
]
],
[
[
215,
63,
1351
],
[
1351,
40,
423
]
],
[
[
215,
25,
1486
],
[
1486,
... | [
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ciclesonide"
]
],
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
],
[
... | Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Ciclesonide
Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone (Compound) resembles Ciclesonide (Compound)
Indinavir may cause a moderate interaction that could exac... |
DB00827 | DB13749 | 646 | 1,473 | [
"DDInter383",
"DDInter1116"
] | Cinoxacin | Magnesium gluconate | Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections. | Magnesium gluconate is a magnesium salt of gluconate. It demonstrates the highest oral bioavailability of magnesium salts and is used as a mineral supplement. Magnesium is ubiquitous in the human body, and is naturally present in many foods, added to other food products, available as a dietary supplement and used as an... | Moderate | 1 | [
[
[
646,
24,
1473
]
],
[
[
646,
63,
544
],
[
544,
24,
1473
]
],
[
[
646,
24,
853
],
[
853,
24,
1473
]
],
[
[
646,
63,
544
],
[
544,
... | [
[
[
"Cinoxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium gluconate"
]
],
[
[
"Cinoxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium sulfate"
... | Cinoxacin may cause a moderate interaction that could exacerbate diseases when taken with Magnesium sulfate and Magnesium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Magnesium gluconate
Cinoxacin may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00872 | DB12364 | 1,080 | 1,421 | [
"DDInter438",
"DDInter200"
] | Conivaptan | Betrixaban | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Major | 2 | [
[
[
1080,
25,
1421
]
],
[
[
1080,
25,
1017
],
[
1017,
24,
1421
]
],
[
[
1080,
24,
1151
],
[
1151,
24,
1421
]
],
[
[
1080,
1,
990
],
[
990,... | [
[
[
"Conivaptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betrixaban"
]
],
[
[
"Conivaptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lorlatinib"
],
[
"Lorlatinib",
"{u} m... | Conivaptan may lead to a major life threatening interaction when taken with Lorlatinib and Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Conivaptan may cause a moderate interaction that could exacerbate diseases when taken with Sunitinib and Sunitinib may cause a ... |
DB00586 | DB09237 | 1,512 | 1,586 | [
"DDInter537",
"DDInter1045"
] | Diclofenac | Levamlodipine | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], an antihypertensive medication. Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. This medication was first marketed in Russia and India before being granted FDA approval. The names S-amlod... | Moderate | 1 | [
[
[
1512,
24,
1586
]
],
[
[
1512,
24,
578
],
[
578,
23,
1586
]
],
[
[
1512,
24,
870
],
[
870,
24,
1586
]
],
[
[
1512,
63,
251
],
[
251,
... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levamlodipine"
]
],
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
],
[... | Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a minor interaction that can limit clinical effects when taken with Levamlodipine
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and ... |
DB00376 | DB01409 | 1,105 | 1,415 | [
"DDInter1870",
"DDInter1815"
] | Trihexyphenidyl | Tiotropium | Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced extrapyramidal disorders.[L31773,L31778] Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity. Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is n... | Tiotropium is a long-acting, antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma.[A180163,L7084,L7087,L7090,L7093] Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and bronchodilation.[A180163,L7084,L... | Moderate | 1 | [
[
[
1105,
24,
1415
]
],
[
[
1105,
6,
4304
],
[
4304,
45,
1415
]
],
[
[
1105,
21,
28680
],
[
28680,
60,
1415
]
],
[
[
1105,
63,
1594
],
[
1... | [
[
[
"Trihexyphenidyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tiotropium"
]
],
[
[
"Trihexyphenidyl",
"{u} (Compound) binds {v} (Gene)",
"CHRM2"
],
[
"CHRM2",
"{u} (Gene) is bound by {v} (Com... | Trihexyphenidyl (Compound) binds CHRM2 (Gene) and CHRM2 (Gene) is bound by Tiotropium (Compound)
Trihexyphenidyl (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Tiotropium (Compound)
Trihexyphenidyl may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and D... |
DB00843 | DB08820 | 479 | 1,478 | [
"DDInter583",
"DDInter997"
] | Donepezil | Ivacaftor | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Minor | 0 | [
[
[
479,
23,
1478
]
],
[
[
479,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
479,
21,
29221
],
[
29221,
60,
1478
]
],
[
[
479,
63,
543
],
[
543,
... | [
[
[
"Donepezil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ivacaftor"
]
],
[
[
"Donepezil",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Donepezil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Donepezil (Compound) causes Infestation (Side Effect) and Infestation (Side Effect) is caused by Ivacaftor (Compound)
Donepezil may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Loper... |
DB00205 | DB01390 | 929 | 1,117 | [
"DDInter1550",
"DDInter1683"
] | Pyrimethamine | Sodium bicarbonate | One of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis. | Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions. | Moderate | 1 | [
[
[
929,
24,
1117
]
],
[
[
929,
21,
28778
],
[
28778,
60,
1117
]
],
[
[
929,
24,
663
],
[
663,
23,
1117
]
],
[
[
929,
24,
1243
],
[
1243,
... | [
[
[
"Pyrimethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium bicarbonate"
]
],
[
[
"Pyrimethamine",
"{u} (Compound) causes {v} (Side Effect)",
"Anaphylactic shock"
],
[
"Anaphylactic shock",
... | Pyrimethamine (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Sodium bicarbonate (Compound)
Pyrimethamine may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a minor interaction that can limit clinic... |
DB00991 | DB06603 | 97 | 39 | [
"DDInter1358",
"DDInter1387"
] | Oxaprozin | Panobinostat | Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
97,
25,
39
]
],
[
[
97,
63,
912
],
[
912,
24,
39
]
],
[
[
97,
24,
578
],
[
578,
63,
39
]
],
[
[
97,
62,
1559
],
[
1559,
24,
... | [
[
[
"Oxaprozin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Oxaprozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Interferon beta-1a"
],
[
"In... | Oxaprozin may cause a moderate interaction that could exacerbate diseases when taken with Interferon beta-1a and Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Panobinostat
Oxaprozin may cause a moderate interaction that could exacerbate diseases when taken with Ticag... |
DB00408 | DB00747 | 1,408 | 1,442 | [
"DDInter1099",
"DDInter1647"
] | Loxapine | Scopolamine | An antipsychotic agent used in schizophrenia. [PubChem] | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | Moderate | 1 | [
[
[
1408,
24,
1442
]
],
[
[
1408,
24,
19
],
[
19,
24,
1442
]
],
[
[
1408,
63,
1089
],
[
1089,
24,
1442
]
],
[
[
1408,
6,
7420
],
[
7420,
... | [
[
[
"Loxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Scopolamine"
]
],
[
[
"Loxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
[
... | Loxapine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Scopolamine
Loxapine may cause a moderate interaction that could exacerbate diseases when taken with Ipratropium and Ipratr... |
DB11718 | DB14575 | 927 | 733 | [
"DDInter640",
"DDInter674"
] | Encorafenib | Eslicarbazepine | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Eslicarbazepine is an anti-epileptic medication available commercially as [eslicarbazepine acetate]. | Moderate | 1 | [
[
[
927,
24,
733
]
],
[
[
927,
63,
1101
],
[
1101,
23,
733
]
],
[
[
927,
63,
1264
],
[
1264,
24,
733
]
],
[
[
927,
25,
351
],
[
351,
... | [
[
[
"Encorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eslicarbazepine"
]
],
[
[
"Encorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
... | Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Eslicarbazepine
Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxe... |
DB00030 | DB00224 | 1,685 | 215 | [
"DDInter934",
"DDInter917"
] | Insulin human | Indinavir | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem] | Moderate | 1 | [
[
[
1685,
24,
215
]
],
[
[
1685,
24,
798
],
[
798,
1,
215
]
],
[
[
1685,
24,
303
],
[
303,
62,
215
]
],
[
[
1685,
24,
1151
],
[
1151,
... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indinavir"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nelfinavir"
],
... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Nelfinavir and Nelfinavir (Compound) resembles Indinavir (Compound)
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Medroxyprogesterone acetate and Medroxyprogesterone acetate may ... |
DB01611 | DB12245 | 1,487 | 823 | [
"DDInter893",
"DDInter1863"
] | Hydroxychloroquine | Triclabendazole | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Major | 2 | [
[
[
1487,
25,
823
]
],
[
[
1487,
62,
1247
],
[
1247,
23,
823
]
],
[
[
1487,
63,
112
],
[
112,
23,
823
]
],
[
[
1487,
25,
1612
],
[
1612,
... | [
[
[
"Hydroxychloroquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Triclabendazole"
]
],
[
[
"Hydroxychloroquine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
]... | Hydroxychloroquine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when tak... |
DB00963 | DB01099 | 1,263 | 1,272 | [
"DDInter241",
"DDInter744"
] | Bromfenac | Flucytosine | Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool f... | A fluorinated cytosine analog that is used as an antifungal agent. | Moderate | 1 | [
[
[
1263,
24,
1272
]
],
[
[
1263,
7,
6952
],
[
6952,
46,
1272
]
],
[
[
1263,
21,
28762
],
[
28762,
60,
1272
]
],
[
[
1263,
24,
1448
],
[
1... | [
[
[
"Bromfenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flucytosine"
]
],
[
[
"Bromfenac",
"{u} (Compound) upregulates {v} (Gene)",
"MCOLN1"
],
[
"MCOLN1",
"{u} (Gene) is upregulated by {v} (... | Bromfenac (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Flucytosine (Compound)
Bromfenac (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Flucytosine (Compound)
Bromfenac may cause a moderate interaction that could exacerbate diseases when taken with Streptomyc... |
DB01110 | DB04845 | 86 | 309 | [
"DDInter1209",
"DDInter1001"
] | Miconazole | Ixabepilone | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Moderate | 1 | [
[
[
86,
24,
309
]
],
[
[
86,
6,
8374
],
[
8374,
45,
309
]
],
[
[
86,
21,
28987
],
[
28987,
60,
309
]
],
[
[
86,
62,
307
],
[
307,
23... | [
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
]
],
[
[
"Miconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Miconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ixabepilone (Compound)
Miconazole (Compound) causes Chills (Side Effect) and Chills (Side Effect) is caused by Ixabepilone (Compound)
Miconazole may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil m... |
DB01169 | DB09020 | 57 | 28 | [
"DDInter120",
"DDInter212"
] | Arsenic trioxide | Bisacodyl | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
57,
24,
28
]
],
[
[
57,
6,
9842
],
[
9842,
46,
28
]
],
[
[
57,
64,
739
],
[
739,
24,
28
]
],
[
[
57,
25,
540
],
[
540,
24,
... | [
[
[
"Arsenic trioxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Arsenic trioxide",
"{u} (Compound) binds {v} (Gene)",
"CYP1A1"
],
[
"CYP1A1",
"{u} (Gene) is upregulated by... | Arsenic trioxide (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is upregulated by Bisacodyl (Compound)
Arsenic trioxide may lead to a major life threatening interaction when taken with Lomefloxacin and Lomefloxacin may cause a moderate interaction that could exacerbate diseases when taken with Bisacodyl
Arsenic triox... |
DB00850 | DB01142 | 1,630 | 1,264 | [
"DDInter1432",
"DDInter593"
] | Perphenazine | Doxepin | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
1630,
24,
1264
]
],
[
[
1630,
1,
508
],
[
508,
24,
1264
]
],
[
[
1630,
40,
225
],
[
225,
1,
1264
]
],
[
[
1630,
35,
401
],
[
401,
... | [
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Perphenazine",
"{u} (Compound) resembles {v} (Compound)",
"Promazine"
],
[
"Promazine",
"{u} may cause a moderate... | Perphenazine (Compound) resembles Promazine (Compound) and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Perphenazine (Compound) resembles Thiothixene (Compound) and Thiothixene (Compound) resembles Doxepin (Compound)
Perphenazine (Compound) resembles Promethazine (Co... |
DB00006 | DB00533 | 942 | 1,416 | [
"DDInter217",
"DDInter1613"
] | Bivalirudin | Rofecoxib | Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important t... | Rofecoxib is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras. Rofecoxib is a solid. This compound belongs to the stilbenes. These are organic compounds containing a 1,2-diphenylethylene m... | Moderate | 1 | [
[
[
942,
24,
1416
]
],
[
[
942,
25,
1409
],
[
1409,
63,
1416
]
],
[
[
942,
64,
1578
],
[
1578,
24,
1416
]
],
[
[
942,
25,
20
],
[
20,
... | [
[
[
"Bivalirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rofecoxib"
]
],
[
[
"Bivalirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apixaban"
],
[
"Apixaban",
... | Bivalirudin may lead to a major life threatening interaction when taken with Apixaban and Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Rofecoxib
Bivalirudin may lead to a major life threatening interaction when taken with Lepirudin and Lepirudin may cause a moderate interacti... |
DB01132 | DB01234 | 1,130 | 1,220 | [
"DDInter1472",
"DDInter513"
] | Pioglitazone | Dexamethasone | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
1130,
24,
1220
]
],
[
[
1130,
63,
870
],
[
870,
1,
1220
]
],
[
[
1130,
63,
175
],
[
175,
40,
1220
]
],
[
[
1130,
62,
1103
],
[
1103,
... | [
[
[
"Pioglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Pioglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
... | Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles... |
DB05239 | DB11718 | 866 | 927 | [
"DDInter425",
"DDInter640"
] | Cobimetinib | Encorafenib | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
866,
24,
927
]
],
[
[
866,
63,
495
],
[
495,
24,
927
]
],
[
[
866,
24,
165
],
[
165,
24,
927
]
],
[
[
866,
24,
484
],
[
484,
63,... | [
[
[
"Cobimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Cobimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ezogabine"
],
[
... | Cobimetinib may cause a moderate interaction that could exacerbate diseases when taken with Ezogabine and Ezogabine may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Cobimetinib may cause a moderate interaction that could exacerbate diseases when taken with Tolvaptan and Tolvap... |
DB00213 | DB00279 | 837 | 1,152 | [
"DDInter1388",
"DDInter1074"
] | Pantoprazole | Liothyronine | Pantoprazole is a first-generation proton pump inhibitor (PPI) used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zolling... | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | Moderate | 1 | [
[
[
837,
24,
1152
]
],
[
[
837,
24,
624
],
[
624,
40,
1152
]
],
[
[
837,
6,
4973
],
[
4973,
45,
1152
]
],
[
[
837,
21,
29118
],
[
29118,
... | [
[
[
"Pantoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liothyronine"
]
],
[
[
"Pantoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liotrix"
],
[... | Pantoprazole may cause a moderate interaction that could exacerbate diseases when taken with Liotrix and Liotrix (Compound) resembles Liothyronine (Compound)
Pantoprazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Liothyronine (Compound)
Pantoprazole (Compound) causes Tachycardia (Side Effect) and Tachy... |
DB00535 | DB01592 | 1,145 | 1,596 | [
"DDInter315",
"DDInter975"
] | Cefdinir | Iron | Cefdinir, also known as Omnicef, is a semi-synthetic, broad-spectrum antibiotic belonging to the third generation of the cephalosporin class. It has been proven to be effective for the treatment of common bacterial infections in the ear, sinus, throat, lungs, and skin. Cefdinir was approved by the FDA in 1997 to treat ... | A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletio... | Moderate | 1 | [
[
[
1145,
24,
1596
]
],
[
[
1145,
21,
29276
],
[
29276,
60,
1596
]
],
[
[
1145,
24,
1096
],
[
1096,
23,
1596
]
],
[
[
1145,
24,
1384
],
[
... | [
[
[
"Cefdinir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron"
]
],
[
[
"Cefdinir",
"{u} (Compound) causes {v} (Side Effect)",
"Haemoglobin"
],
[
"Haemoglobin",
"{u} (Side Effect) is caused by ... | Cefdinir (Compound) causes Haemoglobin (Side Effect) and Haemoglobin (Side Effect) is caused by Iron (Compound)
Cefdinir may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid and Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with I... |
DB06317 | DB12240 | 1,626 | 110 | [
"DDInter630",
"DDInter1485"
] | Elotuzumab | Polatuzumab vedotin | Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family... | Polatuzumab vedotin is a CD79b-directed antibody-drug conjugate that delivers monomethyl auristatin E (MMAE), an anti-mitotic agent, to cancer cells. The drug consists of three components - a humanized immunoglobulin G1 (IgG1) monoclonal antibody specific for human CD79b (polatuzumab), MMAE, and protease-cleavable link... | Moderate | 1 | [
[
[
1626,
24,
110
]
],
[
[
1626,
63,
467
],
[
467,
24,
110
]
],
[
[
1626,
24,
1593
],
[
1593,
24,
110
]
],
[
[
1626,
24,
148
],
[
148,
... | [
[
[
"Elotuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polatuzumab vedotin"
]
],
[
[
"Elotuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Simvastatin"
]... | Elotuzumab may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Polatuzumab vedotin
Elotuzumab may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib... |
DB00377 | DB01182 | 1,494 | 371 | [
"DDInter1382",
"DDInter1534"
] | Palonosetron | Propafenone | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. | Moderate | 1 | [
[
[
1494,
24,
371
]
],
[
[
1494,
63,
847
],
[
847,
1,
371
]
],
[
[
1494,
25,
704
],
[
704,
1,
371
]
],
[
[
1494,
24,
675
],
[
675,
4... | [
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propafenone"
]
],
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atomoxetine"
],
... | Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine (Compound) resembles Propafenone (Compound)
Palonosetron may lead to a major life threatening interaction when taken with Fentanyl and Fentanyl (Compound) resembles Propafenone (Compound)
Palonosetro... |
DB00026 | DB10276 | 1,184 | 1,624 | [
"DDInter94",
"DDInter1623"
] | Anakinra | Rotavirus vaccine | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Major | 2 | [
[
[
1184,
25,
1624
]
],
[
[
1184,
24,
617
],
[
617,
24,
1624
]
],
[
[
1184,
24,
552
],
[
552,
25,
1624
]
],
[
[
1184,
25,
1583
],
[
1583,
... | [
[
[
"Anakinra",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Budesonide"
],
[
"Budeson... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Rotavirus vaccine
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Carmustine and Car... |
DB00812 | DB08899 | 998 | 129 | [
"DDInter1451",
"DDInter649"
] | Phenylbutazone | Enzalutamide | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
998,
24,
129
]
],
[
[
998,
6,
8374
],
[
8374,
45,
129
]
],
[
[
998,
62,
608
],
[
608,
23,
129
]
],
[
[
998,
25,
1510
],
[
1510,
... | [
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Phenylbutazone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (C... | Phenylbutazone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Phenylbutazone may cause a minor interaction that can limit clinical effects when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Enzalutamide
Phenylbutazo... |
DB08908 | DB15719 | 713 | 487 | [
"DDInter564",
"DDInter171"
] | Dimethyl fumarate | Belantamab mafodotin | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Belantamab mafodotin, or GSK2857916, is an afucosylated monoclonal antibody that targets B cell maturation antigen conjugated to the microtubule disrupter monomethyl auristatin-F (MMAF). Belantamab mafodotin was granted FDA accelerated approval on 5 August 2020 for the treatment of multiple myeloma; however, its manufa... | Moderate | 1 | [
[
[
713,
24,
487
]
],
[
[
713,
63,
259
],
[
259,
24,
487
]
],
[
[
713,
24,
1362
],
[
1362,
24,
487
]
],
[
[
713,
64,
976
],
[
976,
2... | [
[
[
"Dimethyl fumarate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Belantamab mafodotin"
]
],
[
[
"Dimethyl fumarate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ril... | Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Belantamab mafodotin
Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00987 | DB01177 | 1,224 | 77 | [
"DDInter461",
"DDInter904"
] | Cytarabine (liposomal) | Idarubicin | Cytarabine can cause developmental toxicity according to an independent committee of scientific and health experts. | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Moderate | 1 | [
[
[
1224,
24,
77
]
],
[
[
1224,
5,
11555
],
[
11555,
44,
77
]
],
[
[
1224,
7,
5057
],
[
5057,
46,
77
]
],
[
[
1224,
18,
8527
],
[
8527,
... | [
[
[
"Cytarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idarubicin"
]
],
[
[
"Cytarabine",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Diseas... | Cytarabine may cause a moderate interaction that could exacerbate diseases when taken with Idarubicin
Cytarabine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Idarubicin (Compound)
Cytarabine (Compound) upregulates IL1B (Gene) and IL1B (Gene) is upregulated by Idarubicin ... |
DB00850 | DB01156 | 1,630 | 593 | [
"DDInter1432",
"DDInter252"
] | Perphenazine | Bupropion | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Major | 2 | [
[
[
1630,
25,
593
]
],
[
[
1630,
6,
3486
],
[
3486,
45,
593
]
],
[
[
1630,
18,
7359
],
[
7359,
57,
593
]
],
[
[
1630,
21,
29087
],
[
29087... | [
[
[
"Perphenazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bupropion"
]
],
[
[
"Perphenazine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",
"Bupr... | Perphenazine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Bupropion (Compound)
Perphenazine (Compound) downregulates TXNDC9 (Gene) and TXNDC9 (Gene) is downregulated by Bupropion (Compound)
Perphenazine (Compound) causes Amenorrhoea (Side Effect) and Amenorrhoea (Side Effect) is caused by Bupropion (Com... |
DB00743 | DB01229 | 808 | 973 | [
"DDInter792",
"DDInter1378"
] | Gadobenic acid | Paclitaxel (protein-bound) | Gadobenic acid, usually available in the salt form gadobenate dimeglumine, is a linear MRI gadolinium-based contrast agent (GBCA) used primarily for MR imaging of the liver. It differs from other GBCAs due to the benzene ring that confers weak protein binding, thus leading to an increased R1 and R2 relaxivity. As gadob... | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Moderate | 1 | [
[
[
808,
24,
973
]
],
[
[
808,
21,
29267
],
[
29267,
60,
973
]
],
[
[
808,
63,
134
],
[
134,
24,
973
]
],
[
[
808,
24,
772
],
[
772,
... | [
[
[
"Gadobenic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Gadobenic acid",
"{u} (Compound) causes {v} (Side Effect)",
"Alanine aminotransferase increased"
],
[
"Alanine ami... | Gadobenic acid may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Gadobenic acid (Compound) causes Alanine aminotransferase increased (Side Effect) and Alanine aminotransferase increased (Side Effect) is caused by Paclitaxel (Compound)
Gadobenic acid may cause a moderate interact... |
DB08815 | DB09330 | 154 | 985 | [
"DDInter1104",
"DDInter1352"
] | Lurasidone | Osimertinib | Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States. | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Moderate | 1 | [
[
[
154,
24,
985
]
],
[
[
154,
24,
1478
],
[
1478,
24,
985
]
],
[
[
154,
24,
1033
],
[
1033,
63,
985
]
],
[
[
154,
63,
597
],
[
597,
... | [
[
[
"Lurasidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osimertinib"
]
],
[
[
"Lurasidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
],
[
... | Lurasidone may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Osimertinib
Lurasidone may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and Alpelisi... |
DB00831 | DB01001 | 1,178 | 688 | [
"DDInter1866",
"DDInter1632"
] | Trifluoperazine | Salbutamol | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Moderate | 1 | [
[
[
1178,
24,
688
]
],
[
[
1178,
63,
874
],
[
874,
24,
688
]
],
[
[
1178,
24,
455
],
[
455,
24,
688
]
],
[
[
1178,
24,
1148
],
[
1148,
... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
]
],
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
... | Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Salmetero... |
DB00586 | DB11901 | 1,512 | 913 | [
"DDInter537",
"DDInter107"
] | Diclofenac | Apalutamide | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
1512,
24,
913
]
],
[
[
1512,
24,
312
],
[
312,
23,
913
]
],
[
[
1512,
25,
279
],
[
279,
24,
913
]
],
[
[
1512,
63,
600
],
[
600,
... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eplerenone"
],
[
... | Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Eplerenone and Eplerenone may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Diclofenac may lead to a major life threatening interaction when taken with Anisindione and Anisindione may cause... |
DB01168 | DB01427 | 1,053 | 1,111 | [
"DDInter1526",
"DDInter91"
] | Procarbazine | Amrinone | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Amrinone (or inamrinone) is a type 3 pyridine phosphodiesterase inhibitor. It is used in the treatment of congestive heart failure. | Moderate | 1 | [
[
[
1053,
24,
1111
]
],
[
[
1053,
63,
444
],
[
444,
1,
1111
]
],
[
[
1053,
21,
28762
],
[
28762,
60,
444
],
[
444,
1,
1111
]
],
[
[
1053,
... | [
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amrinone"
]
],
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milrinone"
],
[
... | Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Milrinone and Milrinone (Compound) resembles Amrinone (Compound)
Procarbazine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Milrinone (Compound) and Milrinone (Compound) resembles Amrinone (Co... |
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