drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00115 | DB05351 | 227 | 101 | [
"DDInter451",
"DDInter519"
] | Cyanocobalamin | Dexlansoprazole | Cyanocobalamin (commonly known as Vitamin B12) is a highly complex, essential vitamin, owing its name to the fact that it contains the mineral, cobalt. This vitamin is produced naturally by bacteria, and is necessary for DNA synthesis and cellular energy production. Vitamin B12 has many forms, including the cyano-, met... | Dexlansoprazole is a new-generation proton pump inhibitor (PPI) used for the management of symptoms associated with gastroesophageal reflux disease (GERD) and erosive esophagitis. Dexlansoprazole is the R-enantiomer of , which is composed of a racemic mixture of the R- and S-enantiomers. Compared to the older generatio... | Minor | 0 | [
[
[
227,
23,
101
]
],
[
[
227,
6,
8300
],
[
8300,
45,
663
],
[
663,
25,
101
]
],
[
[
227,
6,
4182
],
[
4182,
46,
1213
],
[
1213,
25,
... | [
[
[
"Cyanocobalamin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dexlansoprazole"
]
],
[
[
"Cyanocobalamin",
"{u} (Compound) binds {v} (Gene)",
"MTHFR"
],
[
"MTHFR",
"{u} (Gene) is bound by {v} (Co... | Cyanocobalamin (Compound) binds MTHFR (Gene) and MTHFR (Gene) is bound by Methotrexate (Compound) and Methotrexate may lead to a major life threatening interaction when taken with Dexlansoprazole
Cyanocobalamin (Compound) binds CASP9 (Gene) and CASP9 (Gene) is upregulated by Dasatinib (Compound) and Dasatinib may lead ... |
DB06317 | DB14443 | 1,626 | 987 | [
"DDInter630",
"DDInter1931"
] | Elotuzumab | Vibrio cholerae CVD 103-HgR strain live antigen | Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family... | _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against _Vibrio cholerae_ serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by _Vibrio cholerae_, which is gram-negative bacteria. Two serogroups of _V. cholerae_, O1 and O139, ... | Moderate | 1 | [
[
[
1626,
24,
987
]
],
[
[
1626,
24,
1480
],
[
1480,
24,
987
]
],
[
[
1626,
63,
1488
],
[
1488,
24,
987
]
],
[
[
1626,
64,
581
],
[
581,
... | [
[
[
"Elotuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strain live antigen"
]
],
[
[
"Elotuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}... | Elotuzumab may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib and Ixazomib may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen
Elotuzumab may cause a moderate interaction that could exacerbate diseases when... |
DB00682 | DB09030 | 126 | 840 | [
"DDInter1951",
"DDInter1945"
] | Warfarin | Vorapaxar | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expr... | Major | 2 | [
[
[
126,
25,
840
]
],
[
[
126,
23,
944
],
[
944,
62,
840
]
],
[
[
126,
24,
765
],
[
765,
24,
840
]
],
[
[
126,
63,
1416
],
[
1416,
2... | [
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vorapaxar"
]
],
[
[
"Warfarin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile",
... | Warfarin may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Vorapaxar
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Hemin and Hemin may cause a mode... |
DB00352 | DB00570 | 482 | 147 | [
"DDInter1814",
"DDInter1936"
] | Tioguanine | Vinblastine | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Moderate | 1 | [
[
[
482,
24,
147
]
],
[
[
482,
24,
134
],
[
134,
24,
147
]
],
[
[
482,
5,
11555
],
[
11555,
44,
147
]
],
[
[
482,
21,
28658
],
[
28658,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinblastine"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinorelbine"
],
[
... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine
Tioguanine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Vinb... |
DB00285 | DB01611 | 1,100 | 1,487 | [
"DDInter1927",
"DDInter893"
] | Venlafaxine | Hydroxychloroquine | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Major | 2 | [
[
[
1100,
25,
1487
]
],
[
[
1100,
24,
1520
],
[
1520,
25,
1487
]
],
[
[
1100,
6,
12523
],
[
12523,
45,
1487
]
],
[
[
1100,
21,
28658
],
[
... | [
[
[
"Venlafaxine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
],
[
"... | Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Primaquine and Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Venlafaxine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Hydroxychloroquine (Compound)
Venlafaxine (Co... |
DB00619 | DB06700 | 1,419 | 643 | [
"DDInter909",
"DDInter511"
] | Imatinib | Desvenlafaxine | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of ad... | Moderate | 1 | [
[
[
1419,
24,
643
]
],
[
[
1419,
63,
1100
],
[
1100,
1,
643
]
],
[
[
1419,
6,
8374
],
[
8374,
45,
643
]
],
[
[
1419,
21,
28709
],
[
28709,... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desvenlafaxine"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venlafaxine"
],
[
... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine (Compound) resembles Desvenlafaxine (Compound)
Imatinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Desvenlafaxine (Compound)
Imatinib (Compound) causes Decreased appetite (Side Effect) ... |
DB09564 | DB14751 | 1,296 | 388 | [
"DDInter930",
"DDInter1132"
] | Insulin degludec | Mecasermin rinfabate | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Mecasermin rinfabate is approved for severe primary insulin-like growth factor (IGF) deficiency or in patients with GH gene deletion who have developed antibodies to growth hormone (GH). Mecasermin rinfabate is similar to in that both drugs contain recombinant DNA origin insulin-like growth factor 1 (IGF-1). Mecasermin... | Moderate | 1 | [
[
[
1296,
24,
388
]
],
[
[
1296,
24,
877
],
[
877,
24,
388
]
],
[
[
1296,
63,
959
],
[
959,
24,
388
]
],
[
[
1296,
24,
877
],
[
877,
... | [
[
[
"Insulin degludec",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mecasermin rinfabate"
]
],
[
[
"Insulin degludec",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Macim... | Insulin degludec may cause a moderate interaction that could exacerbate diseases when taken with Macimorelin and Macimorelin may cause a moderate interaction that could exacerbate diseases when taken with Mecasermin rinfabate
Insulin degludec may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00675 | DB00976 | 888 | 1,056 | [
"DDInter1744",
"DDInter1758"
] | Tamoxifen | Telithromycin | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Moderate | 1 | [
[
[
888,
24,
1056
]
],
[
[
888,
63,
1570
],
[
1570,
40,
1056
]
],
[
[
888,
6,
7950
],
[
7950,
45,
1056
]
],
[
[
888,
21,
29346
],
[
29346,... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telithromycin"
]
],
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],
[... | Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin (Compound) resembles Telithromycin (Compound)
Tamoxifen (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Telithromycin (Compound)
Tamoxifen (Compound) causes Upset stomach (Side Effect) an... |
DB00990 | DB09280 | 1,547 | 1,604 | [
"DDInter705",
"DDInter1101"
] | Exemestane | Lumacaftor | Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It irreversibly binds to the active site of the enzyme resulting in permanent inhibition. | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Moderate | 1 | [
[
[
1547,
24,
1604
]
],
[
[
1547,
63,
1438
],
[
1438,
24,
1604
]
],
[
[
1547,
1,
1573
],
[
1573,
24,
1604
]
],
[
[
1547,
24,
192
],
[
192,... | [
[
[
"Exemestane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lumacaftor"
]
],
[
[
"Exemestane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estradiol"
],
[
... | Exemestane may cause a moderate interaction that could exacerbate diseases when taken with Estradiol and Estradiol may cause a moderate interaction that could exacerbate diseases when taken with Lumacaftor
Exemestane (Compound) resembles Prednisone (Compound) and Prednisone may cause a moderate interaction that could e... |
DB00518 | DB01259 | 510 | 392 | [
"DDInter35",
"DDInter1024"
] | Albendazole | Lapatinib | A benzimidazole broad-spectrum anthelmintic structurally related to mebendazole that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38) | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
510,
24,
392
]
],
[
[
510,
6,
4973
],
[
4973,
45,
392
]
],
[
[
510,
7,
10780
],
[
10780,
46,
392
]
],
[
[
510,
18,
10643
],
[
10643,
... | [
[
[
"Albendazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Albendazole",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Albendazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lapatinib (Compound)
Albendazole (Compound) upregulates CCNB2 (Gene) and CCNB2 (Gene) is upregulated by Lapatinib (Compound)
Albendazole (Compound) downregulates EAPP (Gene) and EAPP (Gene) is upregulated by Lapatinib (Compound)
Albendazole (Compoun... |
DB00710 | DB09407 | 1,199 | 853 | [
"DDInter897",
"DDInter1114"
] | Ibandronate | Magnesium chloride | Ibandronate, or BM 21.0955, is a third generation, nitrogen containing bisphosphonate similar to [zoledronic acid], [minodronic acid], and [risedronic acid].[A203111,A203138] It is used to prevent and treat postmenopausal osteoporosis.[L13805,L13808] Ibandronate was first described in the literature in 1993 as a treatm... | Magnesium chloride salts are highly soluble in water and the hydrated form of magnesium chloride can be extracted from brine or sea water. | Moderate | 1 | [
[
[
1199,
24,
853
]
],
[
[
1199,
63,
544
],
[
544,
24,
853
]
],
[
[
1199,
24,
460
],
[
460,
63,
853
]
],
[
[
1199,
1,
1008
],
[
1008,
... | [
[
[
"Ibandronate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium chloride"
]
],
[
[
"Ibandronate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium sulfate... | Ibandronate may cause a moderate interaction that could exacerbate diseases when taken with Magnesium sulfate and Magnesium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Magnesium chloride
Ibandronate may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00283 | DB00902 | 701 | 104 | [
"DDInter395",
"DDInter1168"
] | Clemastine | Methdilazine | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Moderate | 1 | [
[
[
701,
24,
104
]
],
[
[
701,
24,
13
],
[
13,
24,
104
]
],
[
[
701,
24,
820
],
[
820,
1,
104
]
],
[
[
701,
24,
537
],
[
537,
40,
... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine... |
DB00348 | DB01200 | 254 | 469 | [
"DDInter1300",
"DDInter243"
] | Nitisinone | Bromocriptine | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. It inhibits prolactin secretion and may be used to treat dysfunctions associated with hyperprolactinemia. Bromocriptine is also indicated for the management of signs and symptoms of Parkinsonian Syndrome, as well as t... | Moderate | 1 | [
[
[
254,
24,
469
]
],
[
[
254,
21,
28847
],
[
28847,
60,
469
]
],
[
[
254,
24,
888
],
[
888,
23,
469
]
],
[
[
254,
24,
530
],
[
530,
... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bromocriptine"
]
],
[
[
"Nitisinone",
"{u} (Compound) causes {v} (Side Effect)",
"Eye disorder"
],
[
"Eye disorder",
"{u} (Side Effect... | Nitisinone (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Bromocriptine (Compound)
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen may cause a minor interaction that can limit clinical effects when taken with Br... |
DB01227 | DB11978 | 1,301 | 124 | [
"DDInter1043",
"DDInter822"
] | Levacetylmethadol | Glasdegib | Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Major | 2 | [
[
[
1301,
25,
124
]
],
[
[
1301,
62,
112
],
[
112,
23,
124
]
],
[
[
1301,
64,
475
],
[
475,
24,
124
]
],
[
[
1301,
63,
688
],
[
688,
... | [
[
[
"Levacetylmethadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glasdegib"
]
],
[
[
"Levacetylmethadol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Levacetylmethadol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Levacetylmethadol may lead to a major life threatening interaction when taken with Morphine and Morphine... |
DB08865 | DB12161 | 1,593 | 730 | [
"DDInter448",
"DDInter512"
] | Crizotinib | Deutetrabenazine | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Deutetrabenazine is a novel, highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor indicated for the management of chorea associated with Huntington’s disease. It is a hexahydro-dimethoxybenzoquinolizine derivative and a deuterated . The presence of deuterium in deutetrabenazine increases the half-lives ... | Major | 2 | [
[
[
1593,
25,
730
]
],
[
[
1593,
63,
112
],
[
112,
23,
730
]
],
[
[
1593,
64,
322
],
[
322,
24,
730
]
],
[
[
1593,
63,
1559
],
[
1559,
... | [
[
[
"Crizotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deutetrabenazine"
]
],
[
[
"Crizotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
"M... | Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Deutetrabenazine
Crizotinib may lead to a major life threatening interaction when taken with Epirubicin and Epirubicin ... |
DB00902 | DB01618 | 104 | 776 | [
"DDInter1168",
"DDInter1239"
] | Methdilazine | Molindone | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to mo... | Moderate | 1 | [
[
[
104,
24,
776
]
],
[
[
104,
63,
100
],
[
100,
24,
776
]
],
[
[
104,
24,
1662
],
[
1662,
63,
776
]
],
[
[
104,
24,
272
],
[
272,
2... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Molindone"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
],
... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Molindone
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Picosulf... |
DB00196 | DB14761 | 600 | 242 | [
"DDInter743",
"DDInter1578"
] | Fluconazole | Remdesivir | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends o... | Moderate | 1 | [
[
[
600,
24,
242
]
],
[
[
600,
25,
467
],
[
467,
24,
242
]
],
[
[
600,
24,
1512
],
[
1512,
24,
242
]
],
[
[
600,
23,
1101
],
[
1101,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
]
],
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Simvastatin"
],
[
"Simvast... | Fluconazole may lead to a major life threatening interaction when taken with Simvastatin and Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may ca... |
DB10315 | DB12498 | 1,137 | 76 | [
"DDInter1127",
"DDInter1238"
] | Measles virus vaccine live attenuated | Mogamulizumab | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Mogamulizumab is a humanized monoclonal antibody (mAb) directed against CC chemokine receptor 4 (CCR4) for the treatment of Mycosis Fungoides (MF) and Sézary Syndrome (SS), the most common subtypes of cutaneous T-cell lymphoma. Cutaneous T-cell lymphomas occur when certain white blood cells, called T cells, become canc... | Major | 2 | [
[
[
1137,
25,
76
]
],
[
[
1137,
64,
1531
],
[
1531,
24,
76
]
],
[
[
1137,
25,
738
],
[
738,
24,
76
]
],
[
[
1137,
25,
676
],
[
676,
... | [
[
[
"Measles virus vaccine live attenuated",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mogamulizumab"
]
],
[
[
"Measles virus vaccine live attenuated",
"{u} may lead to a major life threatening interaction when taken with {v}",
"... | Measles virus vaccine live attenuated may lead to a major life threatening interaction when taken with Canakinumab and Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Mogamulizumab
Measles virus vaccine live attenuated may lead to a major life threatening interaction when tak... |
DB00284 | DB04575 | 1,647 | 35 | [
"DDInter11",
"DDInter1555"
] | Acarbose | Quinestrol | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | The 3-cyclopentyl ether of ethinyl estradiol. | Moderate | 1 | [
[
[
1647,
24,
35
]
],
[
[
1647,
24,
890
],
[
890,
1,
35
]
],
[
[
1647,
24,
984
],
[
984,
40,
35
]
],
[
[
1647,
24,
1021
],
[
1021,
2... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinestrol"
]
],
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mestranol"
],
[
"... | Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Mestranol and Mestranol (Compound) resembles Quinestrol (Compound)
Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Danazol and Danazol (Compound) resembles Quinestrol (Compound)
Acarbose may... |
DB06710 | DB11921 | 1,546 | 1,019 | [
"DDInter1193",
"DDInter492"
] | Methyltestosterone | Deflazacort | A synthetic anabolic steroid used for treating men with testosterone deficiency or similar androgen replacement therapies. Also, has antineoplastic properties and so has been used secondarily in women with advanced breast cancer. Methyltestosterone is a schedule III drug in the US. | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
1546,
24,
1019
]
],
[
[
1546,
40,
443
],
[
443,
24,
1019
]
],
[
[
1546,
63,
959
],
[
959,
24,
1019
]
],
[
[
1546,
1,
1026
],
[
1026,
... | [
[
[
"Methyltestosterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Methyltestosterone",
"{u} (Compound) resembles {v} (Compound)",
"Spironolactone"
],
[
"Spironolactone",
... | Methyltestosterone (Compound) resembles Spironolactone (Compound) and Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Methyltestosterone may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate... |
DB00209 | DB01233 | 352 | 1,311 | [
"DDInter1886",
"DDInter1197"
] | Trospium | Metoclopramide | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Moderate | 1 | [
[
[
352,
24,
1311
]
],
[
[
352,
24,
1401
],
[
1401,
24,
1311
]
],
[
[
352,
6,
12523
],
[
12523,
45,
1311
]
],
[
[
352,
21,
28691
],
[
2869... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
]
],
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procainamide"
],
[
... | Trospium may cause a moderate interaction that could exacerbate diseases when taken with Procainamide and Procainamide may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide
Trospium (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Metoclopramide (Compound)
Trospium (... |
DB01610 | DB08901 | 248 | 1,468 | [
"DDInter1912",
"DDInter1492"
] | Valganciclovir | Ponatinib | Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases. | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
248,
24,
1468
]
],
[
[
248,
24,
478
],
[
478,
24,
1468
]
],
[
[
248,
21,
29271
],
[
29271,
60,
1468
]
],
[
[
248,
63,
589
],
[
589,
... | [
[
[
"Valganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Valganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
... | Valganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Valganciclovir (Compound) causes Migraine (Side Effect) and Migraine (Side Effect) is caused by Ponatinib (Comp... |
DB11581 | DB11732 | 1,456 | 1,097 | [
"DDInter1926",
"DDInter1027"
] | Venetoclax | Lasmiditan | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process,. Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small lym... | Lasmiditan is an oral medication used in the termination of migraine headaches that was first approved for use in the United States in October 2019.[L9338,L9356] It was also approved by the European Commission on August 17, 2022. Traditionally, the triptan class of anti-migraine medications (e.g. [sumatriptan]) have se... | Moderate | 1 | [
[
[
1456,
24,
1097
]
],
[
[
1456,
63,
1181
],
[
1181,
24,
1097
]
],
[
[
1456,
24,
971
],
[
971,
63,
1097
]
],
[
[
1456,
64,
478
],
[
478,
... | [
[
[
"Venetoclax",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lasmiditan"
]
],
[
[
"Venetoclax",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Terfenadine"
],
[
... | Venetoclax may cause a moderate interaction that could exacerbate diseases when taken with Terfenadine and Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Lasmiditan
Venetoclax may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib and Gi... |
DB00736 | DB01592 | 660 | 1,596 | [
"DDInter676",
"DDInter975"
] | Esomeprazole | Iron | Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory... | A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletio... | Moderate | 1 | [
[
[
660,
24,
1596
]
],
[
[
660,
21,
29024
],
[
29024,
60,
1596
]
],
[
[
660,
63,
955
],
[
955,
23,
1596
]
],
[
[
660,
1,
1215
],
[
1215,
... | [
[
[
"Esomeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron"
]
],
[
[
"Esomeprazole",
"{u} (Compound) causes {v} (Side Effect)",
"Hypertension"
],
[
"Hypertension",
"{u} (Side Effect) is ... | Esomeprazole (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Iron (Compound)
Esomeprazole may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolate mofetil and Mycophenolate mofetil may cause a minor interaction that can limit clinical effects... |
DB00553 | DB00795 | 92 | 50 | [
"DDInter1177",
"DDInter1725"
] | Methoxsalen | Sulfasalazine | A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation. | Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down i... | Moderate | 1 | [
[
[
92,
24,
50
]
],
[
[
92,
63,
161
],
[
161,
1,
50
]
],
[
[
92,
7,
7273
],
[
7273,
46,
50
]
],
[
[
92,
63,
590
],
[
590,
24,
... | [
[
[
"Methoxsalen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfasalazine"
]
],
[
[
"Methoxsalen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfadiazine"
],
... | Methoxsalen may cause a moderate interaction that could exacerbate diseases when taken with Sulfadiazine and Sulfadiazine (Compound) resembles Sulfasalazine (Compound)
Methoxsalen (Compound) upregulates GPATCH8 (Gene) and GPATCH8 (Gene) is upregulated by Sulfasalazine (Compound)
Methoxsalen may cause a moderate interac... |
DB01234 | DB09237 | 1,220 | 1,586 | [
"DDInter513",
"DDInter1045"
] | Dexamethasone | Levamlodipine | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], an antihypertensive medication. Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. This medication was first marketed in Russia and India before being granted FDA approval. The names S-amlod... | Moderate | 1 | [
[
[
1220,
24,
1586
]
],
[
[
1220,
25,
466
],
[
466,
62,
1586
]
],
[
[
1220,
24,
578
],
[
578,
23,
1586
]
],
[
[
1220,
63,
1648
],
[
1648,
... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levamlodipine"
]
],
[
[
"Dexamethasone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Darolutamide"
],
[
... | Dexamethasone may lead to a major life threatening interaction when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Levamlodipine
Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor... |
DB00477 | DB09038 | 216 | 1,450 | [
"DDInter363",
"DDInter636"
] | Chlorpromazine | Empagliflozin | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
216,
24,
1450
]
],
[
[
216,
24,
485
],
[
485,
24,
1450
]
],
[
[
216,
24,
659
],
[
659,
63,
1450
]
],
[
[
216,
63,
1179
],
[
1179,
... | [
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentamidine"
... | Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine and Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Vilanter... |
DB00295 | DB01100 | 475 | 1,568 | [
"DDInter1244",
"DDInter1470"
] | Morphine | Pimozide | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Major | 2 | [
[
[
475,
25,
1568
]
],
[
[
475,
25,
78
],
[
78,
40,
1568
]
],
[
[
475,
6,
7940
],
[
7940,
45,
1568
]
],
[
[
475,
21,
29024
],
[
29024,
... | [
[
[
"Morphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pimozide"
]
],
[
[
"Morphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Droperidol"
],
[
"Droperidol",
"{u} (Compou... | Morphine may lead to a major life threatening interaction when taken with Droperidol and Droperidol (Compound) resembles Pimozide (Compound)
Morphine (Compound) binds OPRK1 (Gene) and OPRK1 (Gene) is bound by Pimozide (Compound)
Morphine (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is cau... |
DB01097 | DB06777 | 1,377 | 780 | [
"DDInter1033",
"DDInter348"
] | Leflunomide | Chenodeoxycholic acid | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Chenodeoxycholic acid (or Chenodiol) is an epimer of ursodeoxycholic acid (DB01586). Chenodeoxycholic acid is a bile acid naturally found in the body. It works by dissolving the cholesterol that makes gallstones and inhibiting production of cholesterol in the liver and absorption in the intestines, which helps to decre... | Major | 2 | [
[
[
1377,
25,
780
]
],
[
[
1377,
21,
29404
],
[
29404,
60,
780
]
],
[
[
1377,
24,
279
],
[
279,
24,
780
]
],
[
[
1377,
25,
384
],
[
384,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Chenodeoxycholic acid"
]
],
[
[
"Leflunomide",
"{u} (Compound) causes {v} (Side Effect)",
"Cataract"
],
[
"Cataract",
"{u} (Side Effect) is caused b... | Leflunomide (Compound) causes Cataract (Side Effect) and Cataract (Side Effect) is caused by Chenodeoxycholic acid (Compound)
Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Anisindione and Anisindione may cause a moderate interaction that could exacerbate diseases when taken... |
DB06663 | DB14730 | 1,154 | 1,412 | [
"DDInter1398",
"DDInter264"
] | Pasireotide | Calaspargase pegol | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
1154,
24,
1412
]
],
[
[
1154,
24,
159
],
[
159,
24,
1412
]
],
[
[
1154,
63,
5
],
[
5,
24,
1412
]
],
[
[
1154,
64,
322
],
[
322,
... | [
[
[
"Pasireotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Pasireotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
... | Pasireotide may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Pasireotide may cause a moderate interaction that could exacerbate diseases when taken with Lirag... |
DB04946 | DB06176 | 924 | 1,342 | [
"DDInter907",
"DDInter1616"
] | Iloperidone | Romidepsin | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Major | 2 | [
[
[
924,
25,
1342
]
],
[
[
924,
62,
112
],
[
112,
23,
1342
]
],
[
[
924,
64,
485
],
[
485,
24,
1342
]
],
[
[
924,
25,
1616
],
[
1616,
... | [
[
[
"Iloperidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Romidepsin"
]
],
[
[
"Iloperidone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Iloperidone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Romidepsin
Iloperidone may lead to a major life threatening interaction when taken with Pentamidine and Pentamidine may ... |
DB01210 | DB01362 | 668 | 497 | [
"DDInter1050",
"DDInter960"
] | Levobunolol (ophthalmic) | Iohexol | Levobunolol is a cyclic ketone that is 3,4-dihydronaphthalen-1-one substituted at position 5 by a 3-(tert-butylamino)-2-hydroxypropoxy group (the S-enantiomer). A non-selective beta-adrenergic antagonist used (as its hydrochloride salt) for treatment of glaucoma. It has a role as an antiglaucoma drug and a beta-adrener... | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Moderate | 1 | [
[
[
668,
24,
497
]
],
[
[
668,
24,
258
],
[
258,
40,
497
]
],
[
[
668,
21,
28681
],
[
28681,
60,
497
]
],
[
[
668,
24,
1013
],
[
1013,
... | [
[
[
"Levobunolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iohexol"
]
],
[
[
"Levobunolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodixanol"
],
[
... | Levobunolol may cause a moderate interaction that could exacerbate diseases when taken with Iohexol
Levobunolol may cause a moderate interaction that could exacerbate diseases when taken with Iodixanol and Iodixanol (Compound) resembles Iohexol (Compound)
Levobunolol (Compound) causes Hypersensitivity (Side Effect) and... |
DB01364 | DB01396 | 22 | 1,482 | [
"DDInter650",
"DDInter553"
] | Ephedrine | Digitoxin | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665) | Moderate | 1 | [
[
[
22,
24,
1482
]
],
[
[
22,
63,
1252
],
[
1252,
1,
1482
]
],
[
[
22,
18,
1954
],
[
1954,
57,
1482
]
],
[
[
22,
24,
1117
],
[
1117,
... | [
[
[
"Ephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digitoxin"
]
],
[
[
"Ephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digoxin"
],
[
"D... | Ephedrine may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin (Compound) resembles Digitoxin (Compound)
Ephedrine (Compound) downregulates COG2 (Gene) and COG2 (Gene) is downregulated by Digitoxin (Compound)
Ephedrine may cause a moderate interaction that could exacerbate... |
DB00795 | DB08880 | 50 | 1,510 | [
"DDInter1725",
"DDInter1771"
] | Sulfasalazine | Teriflunomide | Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down i... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
50,
25,
1510
]
],
[
[
50,
24,
1033
],
[
1033,
63,
1510
]
],
[
[
50,
63,
1144
],
[
1144,
24,
1510
]
],
[
[
50,
23,
697
],
[
697,
... | [
[
[
"Sulfasalazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Sulfasalazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
],
[
"Al... | Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and Alpelisib may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide
Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide an... |
DB01064 | DB11901 | 1,148 | 913 | [
"DDInter987",
"DDInter107"
] | Isoprenaline | Apalutamide | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
1148,
24,
913
]
],
[
[
1148,
63,
600
],
[
600,
24,
913
]
],
[
[
1148,
24,
1237
],
[
1237,
24,
913
]
],
[
[
1148,
25,
877
],
[
877,
... | [
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
],
... | Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine a... |
DB00040 | DB00960 | 27 | 887 | [
"DDInter827",
"DDInter1471"
] | Glucagon | Pindolol | Glucagon is a 29 amino acid hormone used as a diagnostic aid in radiologic exams to temporarily inhibit the movement of the gastrointestinal tract and to treat severe hypoglycemia.[L7634,L7637,L7640,L7643,L8519] Glucagon raises blood sugar through activation of hepatic glucagon receptors, stimulating glycogenolysis and... | Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the earl... | Minor | 0 | [
[
[
27,
23,
887
]
],
[
[
27,
23,
819
],
[
819,
40,
887
]
],
[
[
27,
23,
1121
],
[
1121,
1,
887
]
],
[
[
27,
23,
819
],
[
819,
40,
... | [
[
[
"Glucagon",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Pindolol"
]
],
[
[
"Glucagon",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Acebutolol"
],
[
"Acebu... | Glucagon may cause a minor interaction that can limit clinical effects when taken with Acebutolol and Acebutolol (Compound) resembles Pindolol (Compound)
Glucagon may cause a minor interaction that can limit clinical effects when taken with Bisoprolol and Bisoprolol (Compound) resembles Pindolol (Compound)
Glucagon may... |
DB00261 | DB00945 | 702 | 1,479 | [
"DDInter93",
"DDInter20"
] | Anagrelide | Acetylsalicylic acid | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Moderate | 1 | [
[
[
702,
24,
1479
]
],
[
[
702,
24,
1338
],
[
1338,
24,
1479
]
],
[
[
702,
21,
28931
],
[
28931,
60,
1479
]
],
[
[
702,
63,
1684
],
[
1684... | [
[
[
"Anagrelide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
]
],
[
[
"Anagrelide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meclofenamic acid... | Anagrelide may cause a moderate interaction that could exacerbate diseases when taken with Meclofenamic acid and Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid
Anagrelide (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is ... |
DB01142 | DB12267 | 1,264 | 1,476 | [
"DDInter593",
"DDInter233"
] | Doxepin | Brigatinib | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
1264,
24,
1476
]
],
[
[
1264,
24,
1612
],
[
1612,
23,
1476
]
],
[
[
1264,
63,
918
],
[
918,
24,
1476
]
],
[
[
1264,
64,
33
],
[
33,
... | [
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
],
[
"... | Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir and Fostemsavir may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutami... |
DB00741 | DB01100 | 167 | 1,568 | [
"DDInter885",
"DDInter1470"
] | Hydrocortisone | Pimozide | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Major | 2 | [
[
[
167,
25,
1568
]
],
[
[
167,
64,
78
],
[
78,
40,
1568
]
],
[
[
167,
6,
7524
],
[
7524,
45,
1568
]
],
[
[
167,
7,
3163
],
[
3163,
... | [
[
[
"Hydrocortisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pimozide"
]
],
[
[
"Hydrocortisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Droperidol"
],
[
"Droperidol",
... | Hydrocortisone may lead to a major life threatening interaction when taken with Droperidol and Droperidol (Compound) resembles Pimozide (Compound)
Hydrocortisone (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Pimozide (Compound)
Hydrocortisone (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) is up... |
DB01285 | DB01357 | 708 | 890 | [
"DDInter445",
"DDInter1160"
] | Corticotropin | Mestranol | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | The 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives. | Moderate | 1 | [
[
[
708,
24,
890
]
],
[
[
708,
24,
35
],
[
35,
40,
890
]
],
[
[
708,
63,
380
],
[
380,
40,
890
]
],
[
[
708,
63,
559
],
[
559,
1,
... | [
[
[
"Corticotropin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mestranol"
]
],
[
[
"Corticotropin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinestrol"
],
... | Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Quinestrol and Quinestrol (Compound) resembles Mestranol (Compound)
Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Conjugated estrogens and Conjugated estrogens (Compound) resembl... |
DB00011 | DB00773 | 1,451 | 896 | [
"DDInter944",
"DDInter702"
] | Interferon alfa-n1 | Etoposide | Interferon alfa-n1 consists of purified, natural (n is for natural) alpha interferon subtypes, at least two of which are glycosylated. This differs from recombinant alpha interferons, which are individual non-glycosylated proteins produced from individual alpha interferon genes. | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Moderate | 1 | [
[
[
1451,
24,
896
]
],
[
[
1451,
24,
147
],
[
147,
23,
896
]
],
[
[
1451,
24,
700
],
[
700,
63,
896
]
],
[
[
1451,
25,
1477
],
[
1477,
... | [
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
]
],
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinblastine"... | Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine and Vinblastine may cause a minor interaction that can limit clinical effects when taken with Etoposide
Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Atorva... |
DB06616 | DB08901 | 594 | 1,468 | [
"DDInter224",
"DDInter1492"
] | Bosutinib | Ponatinib | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
594,
24,
1468
]
],
[
[
594,
63,
478
],
[
478,
24,
1468
]
],
[
[
594,
6,
5499
],
[
5499,
45,
1468
]
],
[
[
594,
6,
1972
],
[
1972,
... | [
[
[
"Bosutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Bosutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
... | Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Bosutinib (Compound) binds LYN (Gene) and LYN (Gene) is bound by Ponatinib (Compound)
Bosutinib (Compound) binds PRK... |
DB06822 | DB09420 | 802 | 1,074 | [
"DDInter1812",
"DDInter953"
] | Tinzaparin | Iodide I-123 | Tinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for h... | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Moderate | 1 | [
[
[
802,
24,
1074
]
],
[
[
802,
64,
500
],
[
500,
24,
1074
]
],
[
[
802,
24,
1004
],
[
1004,
63,
1074
]
],
[
[
802,
25,
1421
],
[
1421,
... | [
[
[
"Tinzaparin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
]
],
[
[
"Tinzaparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enoxaparin"
],
[
"Enoxapar... | Tinzaparin may lead to a major life threatening interaction when taken with Enoxaparin and Enoxaparin may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123
Tinzaparin may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate and Phenyl salic... |
DB00398 | DB12332 | 79 | 1,619 | [
"DDInter1702",
"DDInter1626"
] | Sorafenib | Rucaparib | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
79,
24,
1619
]
],
[
[
79,
24,
307
],
[
307,
23,
1619
]
],
[
[
79,
23,
112
],
[
112,
23,
1619
]
],
[
[
79,
24,
87
],
[
87,
24,
... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Modafinil"
],
[
... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Sorafenib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazol... |
DB00710 | DB00781 | 1,199 | 1,481 | [
"DDInter897",
"DDInter1489"
] | Ibandronate | Polymyxin B | Ibandronate, or BM 21.0955, is a third generation, nitrogen containing bisphosphonate similar to [zoledronic acid], [minodronic acid], and [risedronic acid].[A203111,A203138] It is used to prevent and treat postmenopausal osteoporosis.[L13805,L13808] Ibandronate was first described in the literature in 1993 as a treatm... | Polymyxin B was discovered in the 1940s. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic[A176426,FDA Label]. All gram-positive bacteria, fungi, and the gram... | Moderate | 1 | [
[
[
1199,
24,
1481
]
],
[
[
1199,
63,
1441
],
[
1441,
40,
1481
]
],
[
[
1199,
21,
28719
],
[
28719,
60,
1481
]
],
[
[
1199,
63,
91
],
[
91... | [
[
[
"Ibandronate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polymyxin B"
]
],
[
[
"Ibandronate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bacitracin"
],
[... | Ibandronate may cause a moderate interaction that could exacerbate diseases when taken with Bacitracin and Bacitracin (Compound) resembles Polymyxin B (Compound)
Ibandronate (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Polymyxin B (Compound)
Ibandronate may cause a moderate interaction that ... |
DB00748 | DB04843 | 662 | 1,511 | [
"DDInter297",
"DDInter1149"
] | Carbinoxamine | Mepenzolate | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ga... | Moderate | 1 | [
[
[
662,
24,
1511
]
],
[
[
662,
64,
675
],
[
675,
24,
1511
]
],
[
[
662,
24,
537
],
[
537,
24,
1511
]
],
[
[
662,
63,
194
],
[
194,
... | [
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
]
],
[
[
"Carbinoxamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dextropropoxyphene"
],
[
... | Carbinoxamine may lead to a major life threatening interaction when taken with Dextropropoxyphene and Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and... |
DB00373 | DB09134 | 461 | 1,552 | [
"DDInter1809",
"DDInter966"
] | Timolol | Ioversol | Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective ag... | Ioversol is a non-ionic compound with a tri-iodinated benzene ring used as a contrast dye in diagnostic procedures to visualize different types of organs and tissues. Iodine has a high atomic density, which gives it the ability to attenuate X-rays. The intravascular administration of iodine compounds, such as ioversol,... | Moderate | 1 | [
[
[
461,
24,
1552
]
],
[
[
461,
63,
1648
],
[
1648,
24,
1552
]
],
[
[
461,
24,
278
],
[
278,
63,
1552
]
],
[
[
461,
1,
729
],
[
729,
... | [
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioversol"
]
],
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
],
[
"Al... | Timolol may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Ioversol
Timolol may cause a moderate interaction that could exacerbate diseases when taken with Iopodic acid and Iopodic ac... |
DB09065 | DB12026 | 760 | 791 | [
"DDInter424",
"DDInter1950"
] | Cobicistat | Voxilaprevir | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Voxilaprevir is a Direct-Acting Antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most c... | Moderate | 1 | [
[
[
760,
24,
791
]
],
[
[
760,
25,
412
],
[
412,
24,
791
]
],
[
[
760,
63,
26
],
[
26,
24,
791
]
],
[
[
760,
64,
866
],
[
866,
24,
... | [
[
[
"Cobicistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Voxilaprevir"
]
],
[
[
"Cobicistat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eluxadoline"
],
[
"Eluxado... | Cobicistat may lead to a major life threatening interaction when taken with Eluxadoline and Eluxadoline may cause a moderate interaction that could exacerbate diseases when taken with Voxilaprevir
Cobicistat may cause a moderate interaction that could exacerbate diseases when taken with Afatinib and Afatinib may cause ... |
DB00372 | DB01080 | 999 | 855 | [
"DDInter1793",
"DDInter1933"
] | Thiethylperazine | Vigabatrin | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Vigabatrin is an analog of gamma-aminobutyric acid ([GABA]), the main inhibitory neurotransmitter in the central nervous system, used in the treatment of refractory seizures and infantile spasms. It irreversibly inhibits the enzyme responsible for GABA metabolism, thereby increasing levels of circulating GABA. Although... | Moderate | 1 | [
[
[
999,
24,
855
]
],
[
[
999,
24,
407
],
[
407,
63,
855
]
],
[
[
999,
24,
401
],
[
401,
24,
855
]
],
[
[
999,
25,
1311
],
[
1311,
6... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vigabatrin"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
],
... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause a moderate interaction that could exacerbate diseases when taken with Vigabatrin
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Pr... |
DB00649 | DB08901 | 231 | 1,468 | [
"DDInter1710",
"DDInter1492"
] | Stavudine | Ponatinib | A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
231,
24,
1468
]
],
[
[
231,
18,
5415
],
[
5415,
46,
1468
]
],
[
[
231,
18,
6351
],
[
6351,
57,
1468
]
],
[
[
231,
21,
28852
],
[
28852... | [
[
[
"Stavudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Stavudine",
"{u} (Compound) downregulates {v} (Gene)",
"UBQLN2"
],
[
"UBQLN2",
"{u} (Gene) is upregulated by {v} (... | Stavudine (Compound) downregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Ponatinib (Compound)
Stavudine (Compound) downregulates COTL1 (Gene) and COTL1 (Gene) is downregulated by Ponatinib (Compound)
Stavudine (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Ponatinib (Co... |
DB00242 | DB06448 | 1,064 | 171 | [
"DDInter392",
"DDInter1087"
] | Cladribine | Lonafarnib | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Moderate | 1 | [
[
[
1064,
24,
171
]
],
[
[
1064,
25,
63
],
[
63,
24,
171
]
],
[
[
1064,
64,
1351
],
[
1351,
24,
171
]
],
[
[
1064,
25,
310
],
[
310,
... | [
[
[
"Cladribine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lonafarnib"
]
],
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teniposide"
],
[
"Teniposide... | Cladribine may lead to a major life threatening interaction when taken with Teniposide and Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Lonafarnib
Cladribine may lead to a major life threatening interaction when taken with Flunisolide and Flunisolide may cause a moderate in... |
DB01105 | DB01579 | 222 | 341 | [
"DDInter1665",
"DDInter1439"
] | Sibutramine | Phendimetrazine | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Phendimetrazine is a weight loss medication. Phendimetrazine is chemically related to amphetamines and is a Schedule III drug under the Convention on Psychotropic Substances and in the US since 1970. | Major | 2 | [
[
[
222,
25,
341
]
],
[
[
222,
63,
499
],
[
499,
1,
341
]
],
[
[
222,
5,
11585
],
[
11585,
44,
341
]
],
[
[
222,
6,
2437
],
[
2437,
... | [
[
[
"Sibutramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phendimetrazine"
]
],
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phensuximide"
],
[
"P... | Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Phensuximide and Phensuximide (Compound) resembles Phendimetrazine (Compound)
Sibutramine (Compound) treats obesity (Disease) and obesity (Disease) is treated by Phendimetrazine (Compound)
Sibutramine (Compound) binds SLC6A3 (Ge... |
DB00106 | DB11718 | 618 | 927 | [
"DDInter4",
"DDInter640"
] | Abarelix | Encorafenib | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
618,
24,
927
]
],
[
[
618,
23,
112
],
[
112,
23,
927
]
],
[
[
618,
24,
720
],
[
720,
24,
927
]
],
[
[
618,
24,
1399
],
[
1399,
6... | [
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Abarelix",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Abarelix may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Encorafenib
Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil and Minera... |
DB04855 | DB09079 | 540 | 1,496 | [
"DDInter602",
"DDInter1296"
] | Dronedarone | Nintedanib | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Nintedanib is a small molecule kinase inhibitor used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC).[L8453,L8459] It was first approved for use in the United States in 2014. Within the spectrum of idiopathic pulmonary fibrosis trea... | Moderate | 1 | [
[
[
540,
24,
1496
]
],
[
[
540,
1,
33
],
[
33,
24,
1496
]
],
[
[
540,
64,
609
],
[
609,
24,
1496
]
],
[
[
540,
63,
267
],
[
267,
24,... | [
[
[
"Dronedarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nintedanib"
]
],
[
[
"Dronedarone",
"{u} (Compound) resembles {v} (Compound)",
"Amiodarone"
],
[
"Amiodarone",
"{u} may cause a moder... | Dronedarone (Compound) resembles Amiodarone (Compound) and Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib
Dronedarone may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exac... |
DB00331 | DB00685 | 1,645 | 1,299 | [
"DDInter1164",
"DDInter1887"
] | Metformin | Trovafloxacin | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Moderate | 1 | [
[
[
1645,
24,
1299
]
],
[
[
1645,
24,
872
],
[
872,
40,
1299
]
],
[
[
1645,
21,
29093
],
[
29093,
60,
1299
]
],
[
[
1645,
24,
848
],
[
848... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trovafloxacin"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gemifloxacin"
],
[... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Trovafloxacin (Compound)
Metformin (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Trovafloxacin (Compound)
Metformin may cause a moderate interacti... |
DB00348 | DB01015 | 254 | 1,247 | [
"DDInter1300",
"DDInter1724"
] | Nitisinone | Sulfamethoxazole | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps i... | Moderate | 1 | [
[
[
254,
24,
1247
]
],
[
[
254,
63,
10
],
[
10,
1,
1247
]
],
[
[
254,
21,
29455
],
[
29455,
60,
1247
]
],
[
[
254,
24,
129
],
[
129,
... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfamethoxazole"
]
],
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapsone"
],
[... | Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Dapsone and Dapsone (Compound) resembles Sulfamethoxazole (Compound)
Nitisinone (Compound) causes Agranulocytosis (Side Effect) and Agranulocytosis (Side Effect) is caused by Sulfamethoxazole (Compound)
Nitisinone may cause a mod... |
DB00696 | DB09074 | 826 | 1,362 | [
"DDInter665",
"DDInter1327"
] | Ergotamine | Olaparib | A vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders. | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
826,
24,
1362
]
],
[
[
826,
40,
588
],
[
588,
24,
1362
]
],
[
[
826,
24,
1478
],
[
1478,
24,
1362
]
],
[
[
826,
63,
353
],
[
353,
... | [
[
[
"Ergotamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Ergotamine",
"{u} (Compound) resembles {v} (Compound)",
"Methylergometrine"
],
[
"Methylergometrine",
"{u} may cau... | Ergotamine (Compound) resembles Methylergometrine (Compound) and Methylergometrine may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Ergotamine may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a moderate interaction ... |
DB00683 | DB09420 | 1,382 | 1,074 | [
"DDInter1212",
"DDInter953"
] | Midazolam | Iodide I-123 | Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called _benzodiazepines_. This drug is unique from others in this class due to its rapid onset of effects and short duration of action. Midazola... | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Moderate | 1 | [
[
[
1382,
24,
1074
]
],
[
[
1382,
24,
516
],
[
516,
24,
1074
]
],
[
[
1382,
1,
902
],
[
902,
24,
1074
]
],
[
[
1382,
62,
251
],
[
251,
... | [
[
[
"Midazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
]
],
[
[
"Midazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
],
... | Midazolam may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine and Levocetirizine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123
Midazolam (Compound) resembles Clobazam (Compound) and Clobazam may cause a moderate interaction that c... |
DB00738 | DB01159 | 485 | 419 | [
"DDInter1420",
"DDInter854"
] | Pentamidine | Halothane | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required... | Moderate | 1 | [
[
[
485,
24,
419
]
],
[
[
485,
6,
8374
],
[
8374,
45,
419
]
],
[
[
485,
23,
112
],
[
112,
23,
419
]
],
[
[
485,
25,
629
],
[
629,
24... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Halothane"
]
],
[
[
"Pentamidine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Pentamidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Halothane (Compound)
Pentamidine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Halothane
Pentamidine may ... |
DB08895 | DB11932 | 976 | 327 | [
"DDInter1825",
"DDInter3"
] | Tofacitinib | Abametapir (topical) | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Abametapir is a member of bipyridines. | Moderate | 1 | [
[
[
976,
24,
327
]
],
[
[
976,
64,
168
],
[
168,
24,
327
]
],
[
[
976,
24,
283
],
[
283,
63,
327
]
],
[
[
976,
63,
868
],
[
868,
24,... | [
[
[
"Tofacitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abametapir"
]
],
[
[
"Tofacitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bortezomib"
],
[
"Bortezom... | Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Tofacitinib may lead to a major life threatening interaction when taken with Bortezomib and Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Tofacitinib may cause a... |
DB00397 | DB01200 | 1,466 | 469 | [
"DDInter1458",
"DDInter243"
] | Phenylpropanolamine | Bromocriptine | Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. | Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. It inhibits prolactin secretion and may be used to treat dysfunctions associated with hyperprolactinemia. Bromocriptine is also indicated for the management of signs and symptoms of Parkinsonian Syndrome, as well as t... | Major | 2 | [
[
[
1466,
25,
469
]
],
[
[
1466,
64,
1131
],
[
1131,
1,
469
]
],
[
[
1466,
25,
826
],
[
826,
1,
469
]
],
[
[
1466,
6,
7950
],
[
7950,
... | [
[
[
"Phenylpropanolamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bromocriptine"
]
],
[
[
"Phenylpropanolamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methysergide"
],
[
"Me... | Phenylpropanolamine may lead to a major life threatening interaction when taken with Methysergide and Methysergide (Compound) resembles Bromocriptine (Compound)
Phenylpropanolamine may lead to a major life threatening interaction when taken with Ergotamine and Ergotamine (Compound) resembles Bromocriptine (Compound)
Ph... |
DB08816 | DB08820 | 578 | 1,478 | [
"DDInter1802",
"DDInter997"
] | Ticagrelor | Ivacaftor | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
578,
24,
1478
]
],
[
[
578,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
578,
54,
19146
],
[
19146,
15,
1478
]
],
[
[
578,
21,
28762
],
[
2876... | [
[
[
"Ticagrelor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Ticagrelor",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Ticagrelor (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Ticagrelor (Compound) is included by Cytochrome P450 3A4 Inhibitors (Pharmacologic Class) and Cytochrome P450 3A4 Inhibitors (Pharmacologic Class) includes Ivacaftor (Compound)
Ticagrelor (Compound) causes Headache (Side Effect... |
DB01181 | DB14783 | 1,532 | 287 | [
"DDInter906",
"DDInter574"
] | Ifosfamide | Diroximel fumarate | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
1532,
24,
287
]
],
[
[
1532,
63,
995
],
[
995,
24,
287
]
],
[
[
1532,
24,
270
],
[
270,
24,
287
]
],
[
[
1532,
74,
450
],
[
450,
... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyurea"
],... | Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyurea and Hydroxyurea may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab... |
DB00889 | DB02959 | 1,133 | 871 | [
"DDInter840",
"DDInter1362"
] | Granisetron | Oxitriptan | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | 5-Hydroxytryptophan (5-HTP), also known as oxitriptan (INN), is a naturally occurring amino acid and metabolic intermediate in the synthesis of serotonin and melatonin. 5-HTP is sold over-the-counter in the United Kingdom, United States and Canada as a dietary supplement for use as an antidepressant, appetite suppressa... | Major | 2 | [
[
[
1133,
25,
871
]
],
[
[
1133,
63,
475
],
[
475,
24,
871
]
],
[
[
1133,
25,
1053
],
[
1053,
25,
871
]
],
[
[
1133,
64,
121
],
[
121,
... | [
[
[
"Granisetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Oxitriptan"
]
],
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Morphine"
],
[
"Morphine",... | Granisetron may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Oxitriptan
Granisetron may lead to a major life threatening interaction when taken with Procarbazine and Procarbazine may lead... |
DB00762 | DB08895 | 613 | 976 | [
"DDInter973",
"DDInter1825"
] | Irinotecan | Tofacitinib | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
613,
25,
976
]
],
[
[
613,
63,
307
],
[
307,
23,
976
]
],
[
[
613,
24,
214
],
[
214,
63,
976
]
],
[
[
613,
24,
86
],
[
86,
24,
... | [
[
[
"Irinotecan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Modafinil"
],
[
"Modafinil"... | Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Tofacitinib
Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostama... |
DB00283 | DB03128 | 701 | 140 | [
"DDInter395",
"DDInter18"
] | Clemastine | Acetylcholine | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | A neurotransmitter. Acetylcholine in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. It is generally not used as an administered drug because it is broken ... | Moderate | 1 | [
[
[
701,
24,
140
]
],
[
[
701,
24,
1376
],
[
1376,
24,
140
]
],
[
[
701,
63,
352
],
[
352,
24,
140
]
],
[
[
701,
35,
1594
],
[
1594,
... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylcholine"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Acetylcholine
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Trospium... |
DB01069 | DB01176 | 401 | 537 | [
"DDInter1533",
"DDInter453"
] | Promethazine | Cyclizine | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Moderate | 1 | [
[
[
401,
24,
537
]
],
[
[
401,
24,
1511
],
[
1511,
63,
537
]
],
[
[
401,
63,
1242
],
[
1242,
24,
537
]
],
[
[
401,
63,
104
],
[
104,
... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
]
],
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
... | Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and C... |
DB00314 | DB01250 | 894 | 712 | [
"DDInter288",
"DDInter1334"
] | Capreomycin | Olsalazine | Cyclic peptide antibiotic similar to viomycin. It is produced by Streptomyces capreolus. | Olsalazine is an aminosalicylate and a prodrug of [mesalamine] (5-aminosalicylic acid, 5-ASA). It was first developed for delivering mesalamine to the colon without the use of [sulfapyridine]. Olsalazine comprises two mesalamine molecules joined by an azo bridge, which is cleaved in the colon. Olsalazine is an anti-inf... | Moderate | 1 | [
[
[
894,
24,
712
]
],
[
[
894,
24,
50
],
[
50,
40,
712
]
],
[
[
894,
25,
416
],
[
416,
24,
712
]
],
[
[
894,
24,
91
],
[
91,
24,
... | [
[
[
"Capreomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olsalazine"
]
],
[
[
"Capreomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfasalazine"
],
... | Capreomycin may cause a moderate interaction that could exacerbate diseases when taken with Sulfasalazine and Sulfasalazine (Compound) resembles Olsalazine (Compound)
Capreomycin may lead to a major life threatening interaction when taken with Kanamycin and Kanamycin may cause a moderate interaction that could exacerba... |
DB00078 | DB06209 | 1,172 | 256 | [
"DDInter898",
"DDInter1508"
] | Ibritumomab tiuxetan | Prasugrel | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversib... | Major | 2 | [
[
[
1172,
25,
256
]
],
[
[
1172,
23,
944
],
[
944,
62,
256
]
],
[
[
1172,
24,
901
],
[
901,
24,
256
]
],
[
[
1172,
24,
1427
],
[
1427,
... | [
[
[
"Ibritumomab tiuxetan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prasugrel"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
... | Ibritumomab tiuxetan may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Prasugrel
Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseases when taken with Milnacip... |
DB11718 | DB11915 | 927 | 1,293 | [
"DDInter640",
"DDInter1909"
] | Encorafenib | Valbenazine | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Moderate | 1 | [
[
[
927,
24,
1293
]
],
[
[
927,
62,
112
],
[
112,
23,
1293
]
],
[
[
927,
63,
521
],
[
521,
24,
1293
]
],
[
[
927,
25,
283
],
[
283,
... | [
[
[
"Encorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valbenazine"
]
],
[
[
"Encorafenib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Encorafenib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Valbenazine
Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Go... |
DB00023 | DB00414 | 305 | 590 | [
"DDInter127",
"DDInter16"
] | Asparaginase Escherichia coli | Acetohexamide | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Moderate | 1 | [
[
[
305,
24,
590
]
],
[
[
305,
24,
1551
],
[
1551,
62,
590
]
],
[
[
305,
24,
651
],
[
651,
63,
590
]
],
[
[
305,
24,
168
],
[
168,
2... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetohexamide"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Methyldopa and Methyldopa may cause a minor interaction that can limit clinical effects when taken with Acetohexamide
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate disease... |
DB00446 | DB00851 | 597 | 611 | [
"DDInter351",
"DDInter463"
] | Chloramphenicol | Dacarbazine | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | Moderate | 1 | [
[
[
597,
24,
611
]
],
[
[
597,
63,
141
],
[
141,
24,
611
]
],
[
[
597,
24,
850
],
[
850,
63,
611
]
],
[
[
597,
24,
896
],
[
896,
24,... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dacarbazine"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Floxuridine"
... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Floxuridine and Floxuridine may cause a moderate interaction that could exacerbate diseases when taken with Dacarbazine
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Brentuxi... |
DB00104 | DB01035 | 966 | 1,401 | [
"DDInter1323",
"DDInter1524"
] | Octreotide | Procainamide | Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may... | A derivative of procaine with less CNS action. | Moderate | 1 | [
[
[
966,
24,
1401
]
],
[
[
966,
21,
28658
],
[
28658,
60,
1401
]
],
[
[
966,
24,
1645
],
[
1645,
24,
1401
]
],
[
[
966,
24,
484
],
[
484,
... | [
[
[
"Octreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procainamide"
]
],
[
[
"Octreotide",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Effect) is caus... | Octreotide (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Procainamide (Compound)
Octreotide may cause a moderate interaction that could exacerbate diseases when taken with Metformin and Metformin may cause a moderate interaction that could exacerbate diseases when taken with Procainam... |
DB01190 | DB01226 | 568 | 1,319 | [
"DDInter398",
"DDInter1235"
] | Clindamycin | Mivacurium | Clindamycin is a semi-synthetic lincosamide antibiotic used in the treatment of a variety of serious infections due to susceptible microorganisms[L11599,L11596] as well as topically for acne vulgaris. It has a relatively narrow spectrum of activity that includes anaerobic bacteria as well as gram-positive cocci and bac... | Mivacurium is a bisbenzylisoquinolinium based neuromuscular blocker or muscle relaxant. It binds competitively to cholinergic receptors on the motor end-plate to antagonize the action of acetylcholine, resulting in a block of neuromuscular transmission. | Moderate | 1 | [
[
[
568,
24,
1319
]
],
[
[
568,
63,
648
],
[
648,
1,
1319
]
],
[
[
568,
21,
28921
],
[
28921,
60,
1319
]
],
[
[
568,
63,
1132
],
[
1132,
... | [
[
[
"Clindamycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mivacurium"
]
],
[
[
"Clindamycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxacurium"
],
[
... | Clindamycin may cause a moderate interaction that could exacerbate diseases when taken with Doxacurium and Doxacurium (Compound) resembles Mivacurium (Compound)
Clindamycin (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Mivacurium (Compound)
Clindamycin may cause a moderate interacti... |
DB00685 | DB11248 | 1,299 | 1,193 | [
"DDInter1887",
"DDInter1965"
] | Trovafloxacin | Zinc gluconate | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA . It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration of common colds and wi... | Moderate | 1 | [
[
[
1299,
24,
1193
]
],
[
[
1299,
24,
1096
],
[
1096,
23,
1193
]
],
[
[
1299,
25,
167
],
[
167,
23,
1193
]
],
[
[
1299,
23,
1307
],
[
1307... | [
[
[
"Trovafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc gluconate"
]
],
[
[
"Trovafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolic acid... | Trovafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid and Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate
Trovafloxacin may lead to a major life threatening interaction when taken with Hydrocortisone... |
DB00065 | DB15699 | 581 | 652 | [
"DDInter923",
"DDInter232"
] | Infliximab | Brexucabtagene autoleucel | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Mantle cell lymphoma is a heterogeneous sub-category of non-Hodgkin's lymphoma that can be classified as either an aggressive nodal or an indolent leukemic non-nodal variant. Despite the introduction of Bruton's tyrosine kinase (BTK) inhibitors such as [ibrutinib] and [acalabrutinib], the prognosis for MCL patients rem... | Major | 2 | [
[
[
581,
25,
652
]
],
[
[
581,
25,
259
],
[
259,
24,
652
]
],
[
[
581,
24,
1430
],
[
1430,
24,
652
]
],
[
[
581,
64,
1184
],
[
1184,
... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brexucabtagene autoleucel"
]
],
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rilonacept"
],
[
"Rilonacept... | Infliximab may lead to a major life threatening interaction when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Brexucabtagene autoleucel
Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipu... |
DB11796 | DB11837 | 1,612 | 1,297 | [
"DDInter786",
"DDInter1351"
] | Fostemsavir | Osilodrostat | Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor. It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir prevents the first step in the... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
1612,
24,
1297
]
],
[
[
1612,
62,
112
],
[
112,
23,
1297
]
],
[
[
1612,
23,
1320
],
[
1320,
63,
1297
]
],
[
[
1612,
62,
353
],
[
353,
... | [
[
[
"Fostemsavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Fostemsavir",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Fostemsavir may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Fostemsavir may cause a minor interaction that can limit clinical effects when taken with Elagolix and Elag... |
DB00619 | DB01244 | 1,419 | 762 | [
"DDInter909",
"DDInter192"
] | Imatinib | Bepridil | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Moderate | 1 | [
[
[
1419,
24,
762
]
],
[
[
1419,
25,
704
],
[
704,
1,
762
]
],
[
[
1419,
6,
12523
],
[
12523,
45,
762
]
],
[
[
1419,
21,
28698
],
[
28698,... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bepridil"
]
],
[
[
"Imatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fentanyl"
],
[
"Fentanyl",
"... | Imatinib may lead to a major life threatening interaction when taken with Fentanyl and Fentanyl (Compound) resembles Bepridil (Compound)
Imatinib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Bepridil (Compound)
Imatinib (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Bep... |
DB00641 | DB08880 | 467 | 1,510 | [
"DDInter1675",
"DDInter1771"
] | Simvastatin | Teriflunomide | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
467,
25,
1510
]
],
[
[
467,
24,
129
],
[
129,
63,
1510
]
],
[
[
467,
24,
1191
],
[
1191,
24,
1510
]
],
[
[
467,
63,
10
],
[
10,
... | [
[
[
"Simvastatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
[
"Enz... | Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide
Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Levodopa and... |
DB01036 | DB12130 | 211 | 1,017 | [
"DDInter1832",
"DDInter1094"
] | Tolterodine | Lorlatinib | Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence. Tolterodine acts on M2 and M3 subtypes of muscarinic receptors. | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
211,
24,
1017
]
],
[
[
211,
63,
126
],
[
126,
24,
1017
]
],
[
[
211,
23,
1493
],
[
1493,
24,
1017
]
],
[
[
211,
62,
1387
],
[
1387,
... | [
[
[
"Tolterodine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Tolterodine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
],
[
... | Tolterodine may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib
Tolterodine may cause a minor interaction that can limit clinical effects when taken with Halofantrine and Halofant... |
DB00911 | DB12240 | 458 | 110 | [
"DDInter1811",
"DDInter1485"
] | Tinidazole | Polatuzumab vedotin | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | Polatuzumab vedotin is a CD79b-directed antibody-drug conjugate that delivers monomethyl auristatin E (MMAE), an anti-mitotic agent, to cancer cells. The drug consists of three components - a humanized immunoglobulin G1 (IgG1) monoclonal antibody specific for human CD79b (polatuzumab), MMAE, and protease-cleavable link... | Moderate | 1 | [
[
[
458,
24,
110
]
],
[
[
458,
24,
129
],
[
129,
23,
110
]
],
[
[
458,
63,
467
],
[
467,
24,
110
]
],
[
[
458,
24,
980
],
[
980,
24,... | [
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polatuzumab vedotin"
]
],
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
... | Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Polatuzumab vedotin
Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Simvastati... |
DB01118 | DB08881 | 33 | 868 | [
"DDInter76",
"DDInter1925"
] | Amiodarone | Vemurafenib | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Major | 2 | [
[
[
33,
25,
868
]
],
[
[
33,
6,
8374
],
[
8374,
45,
868
]
],
[
[
33,
7,
2703
],
[
2703,
46,
868
]
],
[
[
33,
54,
19133
],
[
19133,
1... | [
[
[
"Amiodarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
]
],
[
[
"Amiodarone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Vemura... | Amiodarone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vemurafenib (Compound)
Amiodarone (Compound) upregulates IKZF1 (Gene) and IKZF1 (Gene) is upregulated by Vemurafenib (Compound)
Amiodarone (Compound) is included by P-Glycoprotein Inhibitors (Pharmacologic Class) and P-Glycoprotein Inhibitors (Phar... |
DB00363 | DB00518 | 695 | 510 | [
"DDInter419",
"DDInter35"
] | Clozapine | Albendazole | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | A benzimidazole broad-spectrum anthelmintic structurally related to mebendazole that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38) | Major | 2 | [
[
[
695,
25,
510
]
],
[
[
695,
6,
4973
],
[
4973,
45,
510
]
],
[
[
695,
24,
752
],
[
752,
23,
510
]
],
[
[
695,
25,
484
],
[
484,
63... | [
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Albendazole"
]
],
[
[
"Clozapine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Albendazol... | Clozapine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Albendazole (Compound)
Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Albendazole
Clozapine may lead to ... |
DB01041 | DB11627 | 770 | 1,367 | [
"DDInter1789",
"DDInter860"
] | Thalidomide | Hepatitis B Vaccine (Recombinant) | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. Other causative agents are hepatitis A virus, and the non-A, n... | Moderate | 1 | [
[
[
770,
24,
1367
]
],
[
[
770,
64,
1648
],
[
1648,
24,
1367
]
],
[
[
770,
24,
1480
],
[
1480,
24,
1367
]
],
[
[
770,
25,
1019
],
[
1019,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis B Vaccine (Recombinant)"
]
],
[
[
"Thalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Aldesleukin"
... | Thalidomide may lead to a major life threatening interaction when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant)
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib ... |
DB00619 | DB14568 | 1,419 | 982 | [
"DDInter909",
"DDInter1000"
] | Imatinib | Ivosidenib | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
1419,
25,
982
]
],
[
[
1419,
23,
271
],
[
271,
23,
982
]
],
[
[
1419,
62,
1101
],
[
1101,
23,
982
]
],
[
[
1419,
63,
608
],
[
608,
... | [
[
[
"Imatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Imatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mirabegron"
],
[
"Mirabegron",
... | Imatinib may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Imatinib may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexarotene may c... |
DB00086 | DB01009 | 1,167 | 935 | [
"DDInter1712",
"DDInter1009"
] | Streptokinase | Ketoprofen | Streptokinase, is a sterile, purified preparation of a bacterial protein elaborated by group C (beta) -hemolytic streptococci. | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Moderate | 1 | [
[
[
1167,
24,
935
]
],
[
[
1167,
24,
1274
],
[
1274,
24,
935
]
],
[
[
1167,
24,
886
],
[
886,
1,
935
]
],
[
[
1167,
25,
1046
],
[
1046,
... | [
[
[
"Streptokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
]
],
[
[
"Streptokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
],
... | Streptokinase may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen
Streptokinase may cause a moderate interaction that could exacerbate diseases when taken with Ketorolac a... |
DB00835 | DB09061 | 100 | 1,627 | [
"DDInter245",
"DDInter284"
] | Brompheniramine | Cannabidiol | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
100,
24,
1627
]
],
[
[
100,
63,
1594
],
[
1594,
24,
1627
]
],
[
[
100,
74,
662
],
[
662,
24,
1627
]
],
[
[
100,
24,
516
],
[
516,
... | [
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
... | Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol
Brompheniramine (Compound) resembles Carbinoxamine (Compound) and Brompheniramine may cause a moderate int... |
DB00867 | DB11978 | 1,052 | 124 | [
"DDInter1606",
"DDInter822"
] | Ritodrine | Glasdegib | Adrenergic beta-agonist used to control premature labor. | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
1052,
24,
124
]
],
[
[
1052,
63,
79
],
[
79,
24,
124
]
],
[
[
1052,
24,
688
],
[
688,
24,
124
]
],
[
[
1052,
35,
480
],
[
480,
2... | [
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sorafenib"
],
[
... | Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Glasdegib
Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol ... |
DB00688 | DB11248 | 955 | 1,193 | [
"DDInter1251",
"DDInter1965"
] | Mycophenolate mofetil | Zinc gluconate | Mycophenolate mofetil, also known as MMF or CellCept, is a prodrug of mycophenolic acid, and classified as a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). This drug is an immunosuppressant combined with drugs such as [Cyclosporine] and corticosteroids to prevent organ rejection after hepatic, ren... | Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA . It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration of common colds and wi... | Minor | 0 | [
[
[
955,
23,
1193
]
],
[
[
955,
1,
1096
],
[
1096,
23,
1193
]
],
[
[
955,
24,
1531
],
[
1531,
23,
1193
]
],
[
[
955,
23,
1596
],
[
1596,
... | [
[
[
"Mycophenolate mofetil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
]
],
[
[
"Mycophenolate mofetil",
"{u} (Compound) resembles {v} (Compound)",
"Mycophenolic acid"
],
[
"Mycophenolic... | Mycophenolate mofetil (Compound) resembles Mycophenolic acid (Compound) and Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate
Mycophenolate mofetil may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab and Canakinumab may... |
DB01406 | DB08820 | 984 | 1,478 | [
"DDInter472",
"DDInter997"
] | Danazol | Ivacaftor | A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
984,
24,
1478
]
],
[
[
984,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
984,
21,
30495
],
[
30495,
60,
1478
]
],
[
[
984,
25,
1135
],
[
1135,... | [
[
[
"Danazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Danazol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Danazol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Danazol (Compound) causes Pleuritic pain (Side Effect) and Pleuritic pain (Side Effect) is caused by Ivacaftor (Compound)
Danazol may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a... |
DB01211 | DB08882 | 609 | 1,281 | [
"DDInter393",
"DDInter1070"
] | Clarithromycin | Linagliptin | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
609,
24,
1281
]
],
[
[
609,
24,
1002
],
[
1002,
1,
1281
]
],
[
[
609,
6,
8374
],
[
8374,
45,
1281
]
],
[
[
609,
21,
29081
],
[
29081,
... | [
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
],... | Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Clarithromycin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Linagliptin (Compound)
Clarithromycin (Compound) causes Angioedema (Side Effect... |
DB00622 | DB00687 | 1,081 | 870 | [
"DDInter1287",
"DDInter747"
] | Nicardipine | Fludrocortisone | A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [Pub... | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Moderate | 1 | [
[
[
1081,
24,
870
]
],
[
[
1081,
24,
1220
],
[
1220,
40,
870
]
],
[
[
1081,
63,
251
],
[
251,
40,
870
]
],
[
[
1081,
21,
28936
],
[
28936,... | [
[
[
"Nicardipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
]
],
[
[
"Nicardipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]... | Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Fludrocortisone (Compound)
Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone (Compound) resembles Flu... |
DB00850 | DB01075 | 1,630 | 1,376 | [
"DDInter1432",
"DDInter569"
] | Perphenazine | Diphenhydramine | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
1630,
24,
1376
]
],
[
[
1630,
24,
649
],
[
649,
63,
1376
]
],
[
[
1630,
64,
11
],
[
11,
1,
1376
]
],
[
[
1630,
63,
128
],
[
128,
... | [
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],... | Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Perphenazine may lead to a major life threatening interaction when taken with Toremifene and Toremifene (... |
DB11691 | DB12147 | 1,499 | 241 | [
"DDInter1258",
"DDInter661"
] | Naldemedine | Erdafitinib | Naldemedine is an opioid receptor antagonist [FDA Label]. It is a modified form of to which a side chain has been added to increase molecular weight and polar surface area resulting in restricted transport across the blood brain barrier. Naldemedine was approved in 2017 in both the US and Japan for the treatment of Opi... | In early April of 2019, the US FDA approved Janssen Pharmaceutical Companies' brand name Balversa (erdafitinib) as the first-ever fibroblast growth factor receptor (FGFR) kinase inhibitor indicated for patients with locally advanced or metastatic urothelial carcinoma, with susceptible FGFR3 or FGFR2 genetic alterations... | Moderate | 1 | [
[
[
1499,
24,
241
]
],
[
[
1499,
63,
1456
],
[
1456,
24,
241
]
],
[
[
1499,
24,
1619
],
[
1619,
63,
241
]
],
[
[
1499,
63,
1220
],
[
1220,... | [
[
[
"Naldemedine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Erdafitinib"
]
],
[
[
"Naldemedine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venetoclax"
],
[... | Naldemedine may cause a moderate interaction that could exacerbate diseases when taken with Venetoclax and Venetoclax may cause a moderate interaction that could exacerbate diseases when taken with Erdafitinib
Naldemedine may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Ruca... |
DB00960 | DB08895 | 887 | 976 | [
"DDInter1471",
"DDInter1825"
] | Pindolol | Tofacitinib | Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the earl... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Moderate | 1 | [
[
[
887,
24,
976
]
],
[
[
887,
24,
407
],
[
407,
63,
976
]
],
[
[
887,
63,
475
],
[
475,
24,
976
]
],
[
[
887,
1,
699
],
[
699,
24,
... | [
[
[
"Pindolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib"
]
],
[
[
"Pindolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
],
[
"Opi... | Pindolol may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib
Pindolol may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may cause a ... |
DB00365 | DB01166 | 839 | 477 | [
"DDInter842",
"DDInter379"
] | Grepafloxacin | Cilostazol | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Major | 2 | [
[
[
839,
25,
477
]
],
[
[
839,
23,
112
],
[
112,
23,
477
]
],
[
[
839,
25,
126
],
[
126,
23,
477
]
],
[
[
839,
25,
888
],
[
888,
24,... | [
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cilostazol"
]
],
[
[
"Grepafloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Met... | Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cilostazol
Grepafloxacin may lead to a major life threatening interaction when taken with Warfarin and Warfarin may ca... |
DB00289 | DB11718 | 847 | 927 | [
"DDInter132",
"DDInter640"
] | Atomoxetine | Encorafenib | Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD). Also known as the marketed product Strattera, atomoxetine is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve develop... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
847,
24,
927
]
],
[
[
847,
23,
112
],
[
112,
23,
927
]
],
[
[
847,
24,
720
],
[
720,
24,
927
]
],
[
[
847,
23,
1264
],
[
1264,
2... | [
[
[
"Atomoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Atomoxetine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Atomoxetine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Encorafenib
Atomoxetine may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil and ... |
DB00607 | DB06626 | 1,249 | 263 | [
"DDInter1256",
"DDInter147"
] | Nafcillin | Axitinib | A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be u... | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | Major | 2 | [
[
[
1249,
25,
263
]
],
[
[
1249,
24,
392
],
[
392,
24,
263
]
],
[
[
1249,
24,
1593
],
[
1593,
63,
263
]
],
[
[
1249,
62,
1101
],
[
1101,
... | [
[
[
"Nafcillin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Axitinib"
]
],
[
[
"Nafcillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
],
[
"Lapatinib",
... | Nafcillin may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Axitinib
Nafcillin may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib m... |
DB00594 | DB13620 | 863 | 948 | [
"DDInter68",
"DDInter1499"
] | Amiloride | Potassium gluconate | A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions... | Potassium gluconate is a salt of and is classified as a food additive by the FDA . It is also used as a potassium supplement . Potassium is an essential nutrient. It is the most abundant cation in the intracellular fluid, where it plays a key role in maintaining cell function . In dietary supplements, potassium is ofte... | Major | 2 | [
[
[
863,
25,
948
]
],
[
[
863,
24,
848
],
[
848,
24,
948
]
],
[
[
863,
63,
1512
],
[
1512,
24,
948
]
],
[
[
863,
24,
848
],
[
848,
6... | [
[
[
"Amiloride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Potassium gluconate"
]
],
[
[
"Amiloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
],
[
"Ibup... | Amiloride may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Potassium gluconate
Amiloride may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and D... |
DB00777 | DB01276 | 146 | 123 | [
"DDInter1537",
"DDInter706"
] | Propiomazine | Exenatide | Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Struct... | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Moderate | 1 | [
[
[
146,
24,
123
]
],
[
[
146,
40,
820
],
[
820,
24,
123
]
],
[
[
146,
24,
222
],
[
222,
24,
123
]
],
[
[
146,
24,
1254
],
[
1254,
6... | [
[
[
"Propiomazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
]
],
[
[
"Propiomazine",
"{u} (Compound) resembles {v} (Compound)",
"Alimemazine"
],
[
"Alimemazine",
"{u} may cause a mo... | Propiomazine (Compound) resembles Alimemazine (Compound) and Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Exenatide
Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction tha... |
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