drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00196 | DB00280 | 600 | 494 | [
"DDInter743",
"DDInter575"
] | Fluconazole | Disopyramide | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Major | 2 | [
[
[
600,
25,
494
]
],
[
[
600,
24,
675
],
[
675,
40,
494
]
],
[
[
600,
25,
1301
],
[
1301,
40,
494
]
],
[
[
600,
25,
576
],
[
576,
1... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Disopyramide"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextropropoxyphene"
],
[
... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Dextropropoxyphene and Dextropropoxyphene (Compound) resembles Disopyramide (Compound)
Fluconazole may lead to a major life threatening interaction when taken with Levacetylmethadol and Levacetylmethadol (Compound) resembles Dis... |
DB00945 | DB01193 | 1,479 | 819 | [
"DDInter20",
"DDInter12"
] | Acetylsalicylic acid | Acebutolol | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. | Minor | 0 | [
[
[
1479,
23,
819
]
],
[
[
1479,
23,
887
],
[
887,
1,
819
]
],
[
[
1479,
62,
1121
],
[
1121,
1,
819
]
],
[
[
1479,
6,
4973
],
[
4973,
... | [
[
[
"Acetylsalicylic acid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Acebutolol"
]
],
[
[
"Acetylsalicylic acid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Pindolol"
... | Acetylsalicylic acid may cause a minor interaction that can limit clinical effects when taken with Pindolol and Pindolol (Compound) resembles Acebutolol (Compound)
Acetylsalicylic acid may cause a minor interaction that can limit clinical effects when taken with Bisoprolol and Bisoprolol (Compound) resembles Acebutolol... |
DB00399 | DB00798 | 963 | 1,132 | [
"DDInter1968",
"DDInter815"
] | Zoledronic acid | Gentamicin | Zoledronic acid, or CGP 42'446, is a third generation, nitrogen containing bisphosphonate similar to [ibandronic acid], [minodronic acid], and [risedronic acid]. Zoledronic acid is used to treat and prevent multiple forms of osteoporosis, hypercalcemia of malignancy, multiple myeloma, bone metastases from solid tumors,... | Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negat... | Moderate | 1 | [
[
[
963,
24,
1132
]
],
[
[
963,
21,
28703
],
[
28703,
60,
1132
]
],
[
[
963,
24,
361
],
[
361,
63,
1132
]
],
[
[
963,
24,
1555
],
[
1555,
... | [
[
[
"Zoledronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gentamicin"
]
],
[
[
"Zoledronic acid",
"{u} (Compound) causes {v} (Side Effect)",
"Pruritus"
],
[
"Pruritus",
"{u} (Side Effect)... | Zoledronic acid (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Gentamicin (Compound)
Zoledronic acid may cause a moderate interaction that could exacerbate diseases when taken with Neomycin and Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Gen... |
DB00197 | DB00317 | 1,324 | 883 | [
"DDInter1881",
"DDInter810"
] | Troglitazone | Gefitinib | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | Moderate | 1 | [
[
[
1324,
24,
883
]
],
[
[
1324,
24,
594
],
[
594,
40,
883
]
],
[
[
1324,
24,
1195
],
[
1195,
1,
883
]
],
[
[
1324,
24,
307
],
[
307,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
],
[
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Bosutinib and Bosutinib (Compound) resembles Gefitinib (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Erlotinib and Erlotinib (Compound) resembles Gefitinib (Compound)
Tr... |
DB00370 | DB00682 | 1,251 | 126 | [
"DDInter1230",
"DDInter1951"
] | Mirtazapine | Warfarin | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Moderate | 1 | [
[
[
1251,
24,
126
]
],
[
[
1251,
24,
1376
],
[
1376,
40,
126
]
],
[
[
1251,
6,
3486
],
[
3486,
45,
126
]
],
[
[
1251,
25,
1053
],
[
1053,
... | [
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
]
],
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
... | Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine (Compound) resembles Warfarin (Compound)
Mirtazapine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Warfarin (Compound)
Mirtazapine may lead to a major life threatening interacti... |
DB00673 | DB00701 | 723 | 1,091 | [
"DDInter112",
"DDInter90"
] | Aprepitant | Amprenavir | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Amprenavir is a protease inhibitor used to treat HIV infection. | Moderate | 1 | [
[
[
723,
24,
1091
]
],
[
[
723,
24,
34
],
[
34,
1,
1091
]
],
[
[
723,
6,
10215
],
[
10215,
45,
1091
]
],
[
[
723,
54,
19196
],
[
19196,
... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amprenavir"
]
],
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosamprenavir"
],
[... | Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Fosamprenavir and Fosamprenavir (Compound) resembles Amprenavir (Compound)
Aprepitant (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Amprenavir (Compound)
Aprepitant (Compound) is included by Cytochrome P450 3A4 I... |
DB00196 | DB01166 | 600 | 477 | [
"DDInter743",
"DDInter379"
] | Fluconazole | Cilostazol | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Major | 2 | [
[
[
600,
25,
477
]
],
[
[
600,
6,
8374
],
[
8374,
45,
477
]
],
[
[
600,
21,
30397
],
[
30397,
60,
477
]
],
[
[
600,
23,
801
],
[
801,
... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cilostazol"
]
],
[
[
"Fluconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Cilos... | Fluconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cilostazol (Compound)
Fluconazole (Compound) causes Drug eruption (Side Effect) and Drug eruption (Side Effect) is caused by Cilostazol (Compound)
Fluconazole may cause a minor interaction that can limit clinical effects when taken with Brivaracet... |
DB08871 | DB09570 | 36 | 1,480 | [
"DDInter666",
"DDInter1002"
] | Eribulin | Ixazomib | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Moderate | 1 | [
[
[
36,
24,
1480
]
],
[
[
36,
24,
987
],
[
987,
63,
1480
]
],
[
[
36,
63,
440
],
[
440,
24,
1480
]
],
[
[
36,
24,
810
],
[
810,
24,
... | [
[
[
"Eribulin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixazomib"
]
],
[
[
"Eribulin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strai... | Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen and Vibrio cholerae CVD 103-HgR strain live antigen may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib
Eribulin may cause a moderate interaction ... |
DB00994 | DB01181 | 361 | 1,532 | [
"DDInter1277",
"DDInter906"
] | Neomycin | Ifosfamide | Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as [framycetin], is the most active component of the complex and neomycin C is the isomer o... | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
361,
24,
1532
]
],
[
[
361,
21,
31264
],
[
31264,
60,
1532
]
],
[
[
361,
63,
1132
],
[
1132,
24,
1532
]
],
[
[
361,
24,
445
],
[
445,
... | [
[
[
"Neomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Neomycin",
"{u} (Compound) causes {v} (Side Effect)",
"Nephrotoxicity"
],
[
"Nephrotoxicity",
"{u} (Side Effect) i... | Neomycin (Compound) causes Nephrotoxicity (Side Effect) and Nephrotoxicity (Side Effect) is caused by Ifosfamide (Compound)
Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Gentamicin and Gentamicin may cause a moderate interaction that could exacerbate diseases when taken with I... |
DB00694 | DB11837 | 51 | 1,297 | [
"DDInter485",
"DDInter1351"
] | Daunorubicin | Osilodrostat | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
51,
24,
1297
]
],
[
[
51,
23,
112
],
[
112,
23,
1297
]
],
[
[
51,
24,
466
],
[
466,
62,
1297
]
],
[
[
51,
24,
1320
],
[
1320,
63... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Daunorubicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Daunorubicin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide ... |
DB00220 | DB08875 | 798 | 1,618 | [
"DDInter1276",
"DDInter262"
] | Nelfinavir | Cabozantinib | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
798,
25,
1618
]
],
[
[
798,
25,
1135
],
[
1135,
62,
1618
]
],
[
[
798,
24,
723
],
[
723,
24,
1618
]
],
[
[
798,
24,
384
],
[
384,
... | [
[
[
"Nelfinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Nelfinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} m... | Nelfinavir may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Nelfinavir may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a ... |
DB11979 | DB14881 | 1,320 | 180 | [
"DDInter625",
"DDInter1329"
] | Elagolix | Oliceridine | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Major | 2 | [
[
[
1320,
25,
180
]
],
[
[
1320,
63,
1094
],
[
1094,
24,
180
]
],
[
[
1320,
24,
484
],
[
484,
24,
180
]
],
[
[
1320,
63,
1040
],
[
1040,
... | [
[
[
"Elagolix",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Oliceridine"
]
],
[
[
"Elagolix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metreleptin"
],
[
"Metreleptin"... | Elagolix may cause a moderate interaction that could exacerbate diseases when taken with Metreleptin and Metreleptin may cause a moderate interaction that could exacerbate diseases when taken with Oliceridine
Elagolix may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and Entrec... |
DB01059 | DB11248 | 956 | 1,193 | [
"DDInter1313",
"DDInter1965"
] | Norfloxacin | Zinc gluconate | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA . It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration of common colds and wi... | Moderate | 1 | [
[
[
956,
24,
1193
]
],
[
[
956,
63,
1096
],
[
1096,
23,
1193
]
],
[
[
956,
24,
1596
],
[
1596,
23,
1193
]
],
[
[
956,
64,
167
],
[
167,
... | [
[
[
"Norfloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc gluconate"
]
],
[
[
"Norfloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolic acid"
... | Norfloxacin may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid and Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate
Norfloxacin may cause a moderate interaction that could exacerbate diseases when taken with Iro... |
DB04868 | DB06603 | 478 | 39 | [
"DDInter1293",
"DDInter1387"
] | Nilotinib | Panobinostat | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
478,
25,
39
]
],
[
[
478,
62,
1247
],
[
1247,
23,
39
]
],
[
[
478,
63,
211
],
[
211,
23,
39
]
],
[
[
478,
63,
912
],
[
912,
24,
... | [
[
[
"Nilotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Nilotinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"Sulfam... | Nilotinib may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine a... |
DB00215 | DB01166 | 1,230 | 477 | [
"DDInter388",
"DDInter379"
] | Citalopram | Cilostazol | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Moderate | 1 | [
[
[
1230,
24,
477
]
],
[
[
1230,
6,
8374
],
[
8374,
45,
477
]
],
[
[
1230,
18,
5587
],
[
5587,
57,
477
]
],
[
[
1230,
21,
28919
],
[
28919... | [
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
]
],
[
[
"Citalopram",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Citalopram (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cilostazol (Compound)
Citalopram (Compound) downregulates SCAND1 (Gene) and SCAND1 (Gene) is downregulated by Cilostazol (Compound)
Citalopram (Compound) causes Arthritis (Side Effect) and Arthritis (Side Effect) is caused by Cilostazol (Compound)
... |
DB00398 | DB00831 | 79 | 1,178 | [
"DDInter1702",
"DDInter1866"
] | Sorafenib | Trifluoperazine | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Moderate | 1 | [
[
[
79,
24,
1178
]
],
[
[
79,
64,
695
],
[
695,
40,
1178
]
],
[
[
79,
24,
9
],
[
9,
1,
1178
]
],
[
[
79,
24,
216
],
[
216,
40,
... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
]
],
[
[
"Sorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clozapine"
],
[
"Clozapin... | Sorafenib may lead to a major life threatening interaction when taken with Clozapine and Clozapine (Compound) resembles Trifluoperazine (Compound)
Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Methotrimeprazine and Methotrimeprazine (Compound) resembles Trifluoperazine (Compo... |
DB03128 | DB09076 | 140 | 1,116 | [
"DDInter18",
"DDInter1899"
] | Acetylcholine | Umeclidinium | A neurotransmitter. Acetylcholine in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. It is generally not used as an administered drug because it is broken ... | Umeclidinium is a long-acting muscarinic antagonist (LAMA) used as a maintenance treatment for symptoms of chronic obstructive pulmonary disease (COPD). COPD is a progressive obstructive lung disease characterized by shortness of breath, cough, sputum production, and chronically poor airflow with a forced expiratory vo... | Moderate | 1 | [
[
[
140,
24,
1116
]
],
[
[
140,
24,
849
],
[
849,
24,
1116
]
],
[
[
140,
63,
401
],
[
401,
24,
1116
]
],
[
[
140,
24,
103
],
[
103,
... | [
[
[
"Acetylcholine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Umeclidinium"
]
],
[
[
"Acetylcholine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
... | Acetylcholine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Umeclidinium
Acetylcholine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine ... |
DB00434 | DB00697 | 13 | 876 | [
"DDInter459",
"DDInter1821"
] | Cyproheptadine | Tizanidine | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury . It may also be caused by musculoskeletal injury . Regardless of the cause, muscle spasticity can be an extremely painful and debi... | Moderate | 1 | [
[
[
13,
24,
876
]
],
[
[
13,
24,
1617
],
[
1617,
1,
876
]
],
[
[
13,
10,
11610
],
[
11610,
49,
876
]
],
[
[
13,
18,
17695
],
[
17695,
... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tizanidine"
]
],
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apraclonidine"
... | Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Apraclonidine and Apraclonidine (Compound) resembles Tizanidine (Compound)
Cyproheptadine (Compound) palliates migraine (Disease) and migraine (Disease) is palliated by Tizanidine (Compound)
Cyproheptadine (Compound) downregu... |
DB00777 | DB01233 | 146 | 1,311 | [
"DDInter1537",
"DDInter1197"
] | Propiomazine | Metoclopramide | Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Struct... | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Major | 2 | [
[
[
146,
25,
1311
]
],
[
[
146,
6,
7992
],
[
7992,
45,
1311
]
],
[
[
146,
24,
1383
],
[
1383,
63,
1311
]
],
[
[
146,
63,
662
],
[
662,
... | [
[
[
"Propiomazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Metoclopramide"
]
],
[
[
"Propiomazine",
"{u} (Compound) binds {v} (Gene)",
"CHRM1"
],
[
"CHRM1",
"{u} (Gene) is bound by {v} (Compound)",
"M... | Propiomazine (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Metoclopramide (Compound)
Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate and Sodium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide
... |
DB00384 | DB11827 | 1,275 | 433 | [
"DDInter1859",
"DDInter669"
] | Triamterene | Ertugliflozin | Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side. Since it a... | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
1275,
24,
433
]
],
[
[
1275,
24,
251
],
[
251,
24,
433
]
],
[
[
1275,
63,
999
],
[
999,
24,
433
]
],
[
[
1275,
24,
1019
],
[
1019,
... | [
[
[
"Triamterene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Triamterene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betamethasone"
],
... | Triamterene may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Triamterene may cause a moderate interaction that could exacerbate diseases when taken with Thiethylpe... |
DB01278 | DB09098 | 1,021 | 98 | [
"DDInter1506",
"DDInter1700"
] | Pramlintide | Somatrem | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
1021,
24,
98
]
],
[
[
1021,
63,
168
],
[
168,
23,
98
]
],
[
[
1021,
63,
1573
],
[
1573,
24,
98
]
],
[
[
1021,
24,
34
],
[
34,
24... | [
[
[
"Pramlintide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Pramlintide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Pramlintide may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Somatrem
Pramlintide may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Predniso... |
DB01210 | DB08946 | 668 | 512 | [
"DDInter1050",
"DDInter962"
] | Levobunolol (ophthalmic) | Iopanoic acid | Levobunolol is a cyclic ketone that is 3,4-dihydronaphthalen-1-one substituted at position 5 by a 3-(tert-butylamino)-2-hydroxypropoxy group (the S-enantiomer). A non-selective beta-adrenergic antagonist used (as its hydrochloride salt) for treatment of glaucoma. It has a role as an antiglaucoma drug and a beta-adrener... | Iopanoic acid contains iodine and is useful as a contrast medium in cholecystography. | Moderate | 1 | [
[
[
668,
24,
512
]
],
[
[
668,
24,
1106
],
[
1106,
24,
512
]
],
[
[
668,
24,
777
],
[
777,
63,
512
]
],
[
[
668,
1,
699
],
[
699,
24... | [
[
[
"Levobunolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopanoic acid"
]
],
[
[
"Levobunolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gadofosveset trisodium... | Levobunolol may cause a moderate interaction that could exacerbate diseases when taken with Iopanoic acid
Levobunolol may cause a moderate interaction that could exacerbate diseases when taken with Gadofosveset trisodium and Gadofosveset trisodium may cause a moderate interaction that could exacerbate diseases when tak... |
DB00489 | DB00637 | 17 | 1,557 | [
"DDInter1704",
"DDInter128"
] | Sotalol | Astemizole | Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventric... | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Major | 2 | [
[
[
17,
25,
1557
]
],
[
[
17,
6,
3958
],
[
3958,
45,
1557
]
],
[
[
17,
23,
112
],
[
112,
62,
1557
]
],
[
[
17,
24,
770
],
[
770,
63,... | [
[
[
"Sotalol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Astemizole"
]
],
[
[
"Sotalol",
"{u} (Compound) binds {v} (Gene)",
"KCNH2"
],
[
"KCNH2",
"{u} (Gene) is bound by {v} (Compound)",
"Astemizole"
... | Sotalol (Compound) binds KCNH2 (Gene) and KCNH2 (Gene) is bound by Astemizole (Compound)
Sotalol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Astemizole
Sotalol may cause a mode... |
DB01176 | DB04844 | 537 | 843 | [
"DDInter453",
"DDInter1778"
] | Cyclizine | Tetrabenazine | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008. | Moderate | 1 | [
[
[
537,
24,
843
]
],
[
[
537,
63,
479
],
[
479,
40,
843
]
],
[
[
537,
7,
10439
],
[
10439,
46,
843
]
],
[
[
537,
21,
28698
],
[
28698,
... | [
[
[
"Cyclizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetrabenazine"
]
],
[
[
"Cyclizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
],
[
... | Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepezil (Compound) resembles Tetrabenazine (Compound)
Cyclizine (Compound) upregulates PROS1 (Gene) and PROS1 (Gene) is upregulated by Tetrabenazine (Compound)
Cyclizine (Compound) causes Insomnia (Side Effect) and... |
DB00819 | DB01249 | 471 | 258 | [
"DDInter15",
"DDInter958"
] | Acetazolamide | Iodixanol | One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its ... | Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents. | Moderate | 1 | [
[
[
471,
24,
258
]
],
[
[
471,
24,
497
],
[
497,
1,
258
]
],
[
[
471,
21,
28757
],
[
28757,
60,
258
]
],
[
[
471,
1,
997
],
[
997,
2... | [
[
[
"Acetazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodixanol"
]
],
[
[
"Acetazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iohexol"
],
[
... | Acetazolamide may cause a moderate interaction that could exacerbate diseases when taken with Iohexol and Iohexol (Compound) resembles Iodixanol (Compound)
Acetazolamide (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Iodixanol (Compound)
Acetazolamide (Compound) resembles Methazolami... |
DB01224 | DB01276 | 623 | 123 | [
"DDInter1553",
"DDInter706"
] | Quetiapine | Exenatide | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Moderate | 1 | [
[
[
623,
24,
123
]
],
[
[
623,
40,
867
],
[
867,
24,
123
]
],
[
[
623,
24,
1040
],
[
1040,
63,
123
]
],
[
[
623,
24,
820
],
[
820,
2... | [
[
[
"Quetiapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
]
],
[
[
"Quetiapine",
"{u} (Compound) resembles {v} (Compound)",
"Olanzapine"
],
[
"Olanzapine",
"{u} may cause a moderate... | Quetiapine (Compound) resembles Olanzapine (Compound) and Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Exenatide
Quetiapine may cause a moderate interaction that could exacerbate diseases when taken with Dabrafenib and Dabrafenib may cause a moderate interaction that could ... |
DB01577 | DB06335 | 1,529 | 761 | [
"DDInter1161",
"DDInter1646"
] | Metamfetamine | Saxagliptin | Metamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug, and a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. It is a scheduled drug in most countries due to its high potentia... | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
1529,
24,
761
]
],
[
[
1529,
21,
28681
],
[
28681,
60,
761
]
],
[
[
1529,
63,
104
],
[
104,
24,
761
]
],
[
[
1529,
24,
1296
],
[
1296,... | [
[
[
"Metamfetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Metamfetamine",
"{u} (Compound) causes {v} (Side Effect)",
"Hypersensitivity"
],
[
"Hypersensitivity",
"{u} ... | Metamfetamine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Saxagliptin (Compound)
Metamfetamine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate disease... |
DB01072 | DB01166 | 915 | 477 | [
"DDInter129",
"DDInter379"
] | Atazanavir | Cilostazol | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Major | 2 | [
[
[
915,
25,
477
]
],
[
[
915,
6,
8374
],
[
8374,
45,
477
]
],
[
[
915,
21,
30397
],
[
30397,
60,
477
]
],
[
[
915,
63,
126
],
[
126,
... | [
[
[
"Atazanavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cilostazol"
]
],
[
[
"Atazanavir",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Cilosta... | Atazanavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cilostazol (Compound)
Atazanavir (Compound) causes Drug eruption (Side Effect) and Drug eruption (Side Effect) is caused by Cilostazol (Compound)
Atazanavir may cause a moderate interaction that could exacerbate diseases when taken with Warfarin an... |
DB00059 | DB14761 | 1,560 | 242 | [
"DDInter1404",
"DDInter1578"
] | Pegaspargase | Remdesivir | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends o... | Moderate | 1 | [
[
[
1560,
24,
242
]
],
[
[
1560,
24,
1130
],
[
1130,
24,
242
]
],
[
[
1560,
25,
1377
],
[
1377,
24,
242
]
],
[
[
1560,
63,
491
],
[
491,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitazone"
],
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Pioglitazone and Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir
Pegaspargase may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide ... |
DB00055 | DB00574 | 834 | 121 | [
"DDInter605",
"DDInter717"
] | Drotrecogin alfa | Fenfluramine | Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated th... | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Moderate | 1 | [
[
[
834,
24,
121
]
],
[
[
834,
25,
366
],
[
366,
24,
121
]
],
[
[
834,
25,
292
],
[
292,
63,
121
]
],
[
[
834,
64,
1432
],
[
1432,
2... | [
[
[
"Drotrecogin alfa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fenfluramine"
]
],
[
[
"Drotrecogin alfa",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eptifibatide"
],
[
... | Drotrecogin alfa may lead to a major life threatening interaction when taken with Eptifibatide and Eptifibatide may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine
Drotrecogin alfa may lead to a major life threatening interaction when taken with Regorafenib and Regorafenib may c... |
DB00290 | DB06168 | 329 | 1,531 | [
"DDInter219",
"DDInter281"
] | Bleomycin | Canakinumab | A complex of related glycopeptide antibiotics from <i>Streptomyces verticillus</i> consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin. | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Moderate | 1 | [
[
[
329,
24,
1531
]
],
[
[
329,
63,
1461
],
[
1461,
23,
1531
]
],
[
[
329,
24,
377
],
[
377,
24,
1531
]
],
[
[
329,
24,
1270
],
[
1270,
... | [
[
[
"Bleomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
]
],
[
[
"Bleomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Bleomycin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Canakinumab
Bleomycin may cause a moderate interaction that could exacerbate diseases when taken with Mitomycin and Mitomycin ma... |
DB01168 | DB10583 | 1,053 | 949 | [
"DDInter1526",
"DDInter415"
] | Procarbazine | Clostridium tetani toxoid antigen (formaldehyde inactivated) | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Moderate | 1 | [
[
[
1053,
24,
949
]
],
[
[
1053,
64,
1377
],
[
1377,
24,
949
]
],
[
[
1053,
63,
58
],
[
58,
24,
949
]
],
[
[
1053,
25,
1259
],
[
1259,
... | [
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formaldehyde inactivated)"
]
],
[
[
"Procarbazine",
"{u} may lead to a major life threatening interaction when taken with {... | Procarbazine may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated)
Procarbazine may cause a moderate interaction that could exacerbate disea... |
DB01175 | DB12010 | 318 | 214 | [
"DDInter672",
"DDInter785"
] | Escitalopram | Fostamatinib | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
318,
24,
214
]
],
[
[
318,
62,
723
],
[
723,
24,
214
]
],
[
[
318,
64,
51
],
[
51,
24,
214
]
],
[
[
318,
25,
1250
],
[
1250,
24,... | [
[
[
"Escitalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Escitalopram",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Aprepitant"
],
... | Escitalopram may cause a minor interaction that can limit clinical effects when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Escitalopram may lead to a major life threatening interaction when taken with Daunorubicin and Daunorubicin ma... |
DB00820 | DB09038 | 402 | 1,450 | [
"DDInter1736",
"DDInter636"
] | Tadalafil | Empagliflozin | Tadalafil is a selective phosphodiesterase-5 inhibitor that is used in the treatment of erectile dysfunction (ED), pulmonary arterial hypertension (PAH), and benign prostatic hypertrophy.[L39100, L39105] It was first approved in 2003 by the FDA for use in ED and later in 2009 for PAH. In contrast to other PDE5 inhibito... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
402,
24,
1450
]
],
[
[
402,
62,
1061
],
[
1061,
24,
1450
]
],
[
[
402,
23,
885
],
[
885,
24,
1450
]
],
[
[
402,
24,
1017
],
[
1017,
... | [
[
[
"Tadalafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Tadalafil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Treprostinil"
],
[
... | Tadalafil may cause a minor interaction that can limit clinical effects when taken with Treprostinil and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Tadalafil may cause a minor interaction that can limit clinical effects when taken with Epoprostenol and Epo... |
DB01036 | DB14723 | 211 | 159 | [
"DDInter1832",
"DDInter1026"
] | Tolterodine | Larotrectinib | Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence. Tolterodine acts on M2 and M3 subtypes of muscarinic receptors. | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
211,
24,
159
]
],
[
[
211,
23,
741
],
[
741,
24,
159
]
],
[
[
211,
24,
98
],
[
98,
24,
159
]
],
[
[
211,
63,
597
],
[
597,
24,
... | [
[
[
"Tolterodine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Tolterodine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Rolapitant"
],
[... | Tolterodine may cause a minor interaction that can limit clinical effects when taken with Rolapitant and Rolapitant may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib
Tolterodine may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somat... |
DB04855 | DB08916 | 540 | 26 | [
"DDInter602",
"DDInter32"
] | Dronedarone | Afatinib | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label]. For oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal grow... | Moderate | 1 | [
[
[
540,
24,
26
]
],
[
[
540,
63,
883
],
[
883,
40,
26
]
],
[
[
540,
6,
4973
],
[
4973,
45,
26
]
],
[
[
540,
21,
28809
],
[
28809,
6... | [
[
[
"Dronedarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Afatinib"
]
],
[
[
"Dronedarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
... | Dronedarone may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Afatinib (Compound)
Dronedarone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Afatinib (Compound)
Dronedarone (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Sid... |
DB00798 | DB01339 | 1,132 | 728 | [
"DDInter815",
"DDInter1922"
] | Gentamicin | Vecuronium | Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negat... | Monoquaternary homolog of pancuronium. A non-depolarizing neuromuscular blocking agent with shorter duration of action than pancuronium. Its lack of significant cardiovascular effects and lack of dependence on good kidney function for elimination as well as its short duration of action and easy reversibility provide ad... | Major | 2 | [
[
[
1132,
25,
728
]
],
[
[
1132,
64,
1610
],
[
1610,
1,
728
]
],
[
[
1132,
25,
1579
],
[
1579,
40,
728
]
],
[
[
1132,
21,
28766
],
[
28766... | [
[
[
"Gentamicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vecuronium"
]
],
[
[
"Gentamicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rocuronium"
],
[
"Rocuronium",
"{u} (... | Gentamicin may lead to a major life threatening interaction when taken with Rocuronium and Rocuronium (Compound) resembles Vecuronium (Compound)
Gentamicin may lead to a major life threatening interaction when taken with Pancuronium and Pancuronium (Compound) resembles Vecuronium (Compound)
Gentamicin (Compound) causes... |
DB01030 | DB13985 | 869 | 546 | [
"DDInter1835",
"DDInter1108"
] | Topotecan | Lutetium Lu 177 dotatate | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | A 177Lu-labeled somatostatin analog peptide, Lutetium Lu 177 dotatate belongs to an emerging form of treatments called Peptide Receptor Radionuclide Therapy (PRRT), which involves targeting tumours with molecules carrying radioactive particles that bind to specific receptors expressed by the tumour. Lutetium Lu 177 dot... | Moderate | 1 | [
[
[
869,
24,
546
]
],
[
[
869,
63,
66
],
[
66,
24,
546
]
],
[
[
869,
24,
1683
],
[
1683,
24,
546
]
],
[
[
869,
64,
1555
],
[
1555,
2... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lutetium Lu 177 dotatate"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Efalizumab"
... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Lutetium Lu 177 dotatate
Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Ustekinum... |
DB00641 | DB08904 | 467 | 375 | [
"DDInter1675",
"DDInter342"
] | Simvastatin | Certolizumab pegol | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Moderate | 1 | [
[
[
467,
24,
375
]
],
[
[
467,
24,
231
],
[
231,
24,
375
]
],
[
[
467,
24,
1434
],
[
1434,
63,
375
]
],
[
[
467,
25,
1554
],
[
1554,
... | [
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stavudine"
],... | Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Stavudine and Stavudine may cause a moderate interaction that could exacerbate diseases when taken with Certolizumab pegol
Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Benznidazole ... |
DB01233 | DB11732 | 1,311 | 1,097 | [
"DDInter1197",
"DDInter1027"
] | Metoclopramide | Lasmiditan | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Lasmiditan is an oral medication used in the termination of migraine headaches that was first approved for use in the United States in October 2019.[L9338,L9356] It was also approved by the European Commission on August 17, 2022. Traditionally, the triptan class of anti-migraine medications (e.g. [sumatriptan]) have se... | Moderate | 1 | [
[
[
1311,
24,
1097
]
],
[
[
1311,
63,
701
],
[
701,
24,
1097
]
],
[
[
1311,
24,
478
],
[
478,
24,
1097
]
],
[
[
1311,
64,
999
],
[
999,
... | [
[
[
"Metoclopramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lasmiditan"
]
],
[
[
"Metoclopramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
... | Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Lasmiditan
Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and... |
DB00687 | DB01337 | 870 | 1,579 | [
"DDInter747",
"DDInter1385"
] | Fludrocortisone | Pancuronium | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | A bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent it is more potent than curare but has less effect on the circulatory system and on histamine release. | Moderate | 1 | [
[
[
870,
24,
1579
]
],
[
[
870,
24,
1610
],
[
1610,
1,
1579
]
],
[
[
870,
21,
28876
],
[
28876,
60,
1579
]
],
[
[
870,
1,
1573
],
[
1573,
... | [
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pancuronium"
]
],
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rocuronium"
... | Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Rocuronium and Rocuronium (Compound) resembles Pancuronium (Compound)
Fludrocortisone (Compound) causes Anaphylactoid reaction (Side Effect) and Anaphylactoid reaction (Side Effect) is caused by Pancuronium (Compound)
Fludro... |
DB00465 | DB13620 | 886 | 948 | [
"DDInter1010",
"DDInter1499"
] | Ketorolac | Potassium gluconate | Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, men... | Potassium gluconate is a salt of and is classified as a food additive by the FDA . It is also used as a potassium supplement . Potassium is an essential nutrient. It is the most abundant cation in the intracellular fluid, where it plays a key role in maintaining cell function . In dietary supplements, potassium is ofte... | Moderate | 1 | [
[
[
886,
24,
948
]
],
[
[
886,
25,
848
],
[
848,
24,
948
]
],
[
[
886,
1,
24
],
[
24,
24,
948
]
],
[
[
886,
25,
848
],
[
848,
63,
... | [
[
[
"Ketorolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Potassium gluconate"
]
],
[
[
"Ketorolac",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ibuprofen"
],
[
"Ibup... | Ketorolac may lead to a major life threatening interaction when taken with Ibuprofen and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Potassium gluconate
Ketorolac (Compound) resembles Tolmetin (Compound) and Tolmetin may cause a moderate interaction that could exacerbate di... |
DB06589 | DB14444 | 1,250 | 151 | [
"DDInter1400",
"DDInter924"
] | Pazopanib | Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immuno... | Moderate | 1 | [
[
[
1250,
24,
151
]
],
[
[
1250,
63,
66
],
[
66,
24,
151
]
],
[
[
1250,
24,
1619
],
[
1619,
24,
151
]
],
[
[
1250,
25,
375
],
[
375,
... | [
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)"
]
],
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exa... | Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Pazopanib may cause a moderate interac... |
DB00065 | DB11627 | 581 | 1,367 | [
"DDInter923",
"DDInter860"
] | Infliximab | Hepatitis B Vaccine (Recombinant) | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. Other causative agents are hepatitis A virus, and the non-A, n... | Moderate | 1 | [
[
[
581,
24,
1367
]
],
[
[
581,
25,
1083
],
[
1083,
24,
1367
]
],
[
[
581,
64,
1648
],
[
1648,
24,
1367
]
],
[
[
581,
25,
119
],
[
119,
... | [
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis B Vaccine (Recombinant)"
]
],
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trifluridine"
]... | Infliximab may lead to a major life threatening interaction when taken with Trifluridine and Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant)
Infliximab may lead to a major life threatening interaction when taken with Aldesleukin and Aldesleu... |
DB00333 | DB01619 | 576 | 830 | [
"DDInter1166",
"DDInter1441"
] | Methadone | Phenindamine | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Moderate | 1 | [
[
[
576,
24,
830
]
],
[
[
576,
24,
537
],
[
537,
40,
830
]
],
[
[
576,
24,
13
],
[
13,
24,
830
]
],
[
[
576,
24,
104
],
[
104,
1,
... | [
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
]
],
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
],
[
... | Methadone may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) resembles Phenindamine (Compound)
Methadone may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that... |
DB00280 | DB01128 | 494 | 918 | [
"DDInter575",
"DDInter204"
] | Disopyramide | Bicalutamide | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Major | 2 | [
[
[
494,
25,
918
]
],
[
[
494,
25,
129
],
[
129,
40,
918
]
],
[
[
494,
6,
8374
],
[
8374,
45,
918
]
],
[
[
494,
21,
28642
],
[
28642,
... | [
[
[
"Disopyramide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bicalutamide"
]
],
[
[
"Disopyramide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
],
[
"Enzalutamide",
... | Disopyramide may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide (Compound) resembles Bicalutamide (Compound)
Disopyramide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bicalutamide (Compound)
Disopyramide (Compound) causes Shock (Side Effect) and Shock (Side Ef... |
DB00381 | DB00789 | 376 | 1,431 | [
"DDInter79",
"DDInter796"
] | Amlodipine | Gadopentetic acid | Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial... | A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see pentetic acid), that is given to enhance the image in cranial and spinal MRIs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706) | Moderate | 1 | [
[
[
376,
24,
1431
]
],
[
[
376,
21,
28987
],
[
28987,
60,
1431
]
],
[
[
376,
40,
854
],
[
854,
24,
1431
]
],
[
[
376,
1,
1081
],
[
1081,
... | [
[
[
"Amlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gadopentetic acid"
]
],
[
[
"Amlodipine",
"{u} (Compound) causes {v} (Side Effect)",
"Chills"
],
[
"Chills",
"{u} (Side Effect) is cau... | Amlodipine (Compound) causes Chills (Side Effect) and Chills (Side Effect) is caused by Gadopentetic acid (Compound)
Amlodipine (Compound) resembles Nimodipine (Compound) and Nimodipine may cause a moderate interaction that could exacerbate diseases when taken with Gadopentetic acid
Amlodipine (Compound) resembles Nica... |
DB01452 | DB09472 | 993 | 1,383 | [
"DDInter532",
"DDInter1693"
] | Diamorphine | Sodium sulfate | Diamorphine (heroin) is a narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed) Internationally, diamorphine is ... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
993,
24,
1383
]
],
[
[
993,
63,
1311
],
[
1311,
24,
1383
]
],
[
[
993,
1,
421
],
[
421,
24,
1383
]
],
[
[
993,
62,
22
],
[
22,
2... | [
[
[
"Diamorphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Diamorphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
]... | Diamorphine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Diamorphine (Compound) resembles Hydromorphone (Compound) and Hydromorphone may cause a moderate in... |
DB00019 | DB09074 | 1,257 | 1,362 | [
"DDInter1405",
"DDInter1327"
] | Pegfilgrastim | Olaparib | Pegfilgrastim is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (G-CSF) analogue, [filgrastim]. The drug is approved for use to decrease the incidence of infection, as manifested by febrile neutropenia, in susceptible patients with with non-myeloid cancer receiving myelosuppressive anti... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
1257,
24,
1362
]
],
[
[
1257,
24,
896
],
[
896,
24,
1362
]
],
[
[
1257,
24,
385
],
[
385,
63,
1362
]
],
[
[
1257,
63,
491
],
[
491,
... | [
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
],
[... | Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Isatuximab and Isat... |
DB01169 | DB12825 | 57 | 1,375 | [
"DDInter120",
"DDInter1032"
] | Arsenic trioxide | Lefamulin | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Major | 2 | [
[
[
57,
25,
1375
]
],
[
[
57,
62,
112
],
[
112,
23,
1375
]
],
[
[
57,
24,
659
],
[
659,
24,
1375
]
],
[
[
57,
64,
870
],
[
870,
24,
... | [
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lefamulin"
]
],
[
[
"Arsenic trioxide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Arsenic trioxide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lefamulin
Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Vilanter... |
DB00252 | DB06674 | 362 | 908 | [
"DDInter1460",
"DDInter837"
] | Phenytoin | Golimumab | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Moderate | 1 | [
[
[
362,
24,
908
]
],
[
[
362,
1,
697
],
[
697,
24,
908
]
],
[
[
362,
24,
458
],
[
458,
24,
908
]
],
[
[
362,
23,
608
],
[
608,
24,
... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Golimumab"
]
],
[
[
"Phenytoin",
"{u} (Compound) resembles {v} (Compound)",
"Phenobarbital"
],
[
"Phenobarbital",
"{u} may cause a mode... | Phenytoin (Compound) resembles Phenobarbital (Compound) and Phenobarbital may cause a moderate interaction that could exacerbate diseases when taken with Golimumab
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Tinidazole and Tinidazole may cause a moderate interaction that co... |
DB00446 | DB01166 | 597 | 477 | [
"DDInter351",
"DDInter379"
] | Chloramphenicol | Cilostazol | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Moderate | 1 | [
[
[
597,
24,
477
]
],
[
[
597,
6,
8374
],
[
8374,
45,
477
]
],
[
[
597,
7,
3727
],
[
3727,
46,
477
]
],
[
[
597,
21,
28658
],
[
28658,
... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
]
],
[
[
"Chloramphenicol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (C... | Chloramphenicol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cilostazol (Compound)
Chloramphenicol (Compound) upregulates MAL (Gene) and MAL (Gene) is upregulated by Cilostazol (Compound)
Chloramphenicol (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Cilostazol (Compoun... |
DB01041 | DB01589 | 770 | 481 | [
"DDInter1789",
"DDInter1552"
] | Thalidomide | Quazepam | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Quazepam is a trifluoroethyl benzodiazepine derivative. It was first approved in the US in 1985 and is used as a hypnotic for the treatment of insomnia. It appears to be unique amongst other benzodiazepine derivatives in its relatively high affinity for sleep-promoting α1 subunit-containing GABA<sub>A</sub> receptors a... | Moderate | 1 | [
[
[
770,
24,
481
]
],
[
[
770,
63,
1216
],
[
1216,
1,
481
]
],
[
[
770,
24,
1418
],
[
1418,
1,
481
]
],
[
[
770,
63,
905
],
[
905,
4... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quazepam"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurazepam"
],
[
... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Flurazepam and Flurazepam (Compound) resembles Quazepam (Compound)
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Estazolam and Estazolam (Compound) resembles Quazepam (Compound)
Thal... |
DB00209 | DB00536 | 352 | 1,225 | [
"DDInter1886",
"DDInter848"
] | Trospium | Guanidine | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatmen... | Moderate | 1 | [
[
[
352,
24,
1225
]
],
[
[
352,
21,
28787
],
[
28787,
60,
1225
]
],
[
[
352,
24,
1511
],
[
1511,
63,
1225
]
],
[
[
352,
35,
1192
],
[
1192... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Guanidine"
]
],
[
[
"Trospium",
"{u} (Compound) causes {v} (Side Effect)",
"Dermatitis"
],
[
"Dermatitis",
"{u} (Side Effect) is caused ... | Trospium (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Guanidine (Compound)
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Guanidin... |
DB01381 | DB04932 | 958 | 1,564 | [
"DDInter819",
"DDInter491"
] | Ginkgo biloba | Defibrotide | _Ginkgo biloba_ extract contains a group of terpene lactones (notably, ginkgolides and diterpenes) and ginkgo flavone glycosides (notably, ginkgetin, bilobetin, and sciadopitysin) that have antioxidant and vasoactive properties. Most of the studies that investigate the effect of _ginkgo biloba_ use the standardized ext... | Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Da... | Moderate | 1 | [
[
[
958,
24,
1564
]
],
[
[
958,
63,
1039
],
[
1039,
24,
1564
]
],
[
[
958,
63,
1347
],
[
1347,
25,
1564
]
],
[
[
958,
24,
802
],
[
802,
... | [
[
[
"Ginkgo biloba",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Defibrotide"
]
],
[
[
"Ginkgo biloba",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexfenfluramine"
... | Ginkgo biloba may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine and Dexfenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Defibrotide
Ginkgo biloba may cause a moderate interaction that could exacerbate diseases when taken with Clop... |
DB00215 | DB00341 | 1,230 | 1,242 | [
"DDInter388",
"DDInter343"
] | Citalopram | Cetirizine | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms , . One of the most common uses for this drug is for a condition called _alle... | Moderate | 1 | [
[
[
1230,
24,
1242
]
],
[
[
1230,
24,
537
],
[
537,
63,
1242
]
],
[
[
1230,
6,
10104
],
[
10104,
45,
1242
]
],
[
[
1230,
21,
29323
],
[
29... | [
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cetirizine"
]
],
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
],
[
... | Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine
Citalopram (Compound) binds HRH1 (Gene) and HRH1 (Gene) is bound by Cetirizine (Compound)
Citalopram (Compound) ca... |
DB00900 | DB01229 | 45 | 973 | [
"DDInter544",
"DDInter1378"
] | Didanosine | Paclitaxel (protein-bound) | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-termi... | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Moderate | 1 | [
[
[
45,
24,
973
]
],
[
[
45,
24,
310
],
[
310,
63,
973
]
],
[
[
45,
7,
4456
],
[
4456,
46,
973
]
],
[
[
45,
6,
4071
],
[
4071,
57,
... | [
[
[
"Didanosine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Didanosine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Didanosine may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Didanosine may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Didanosi... |
DB00295 | DB00327 | 475 | 421 | [
"DDInter1244",
"DDInter890"
] | Morphine | Hydromorphone | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of [morphine] that has been available clinically since 1920. Structurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 a... | Major | 2 | [
[
[
475,
25,
421
]
],
[
[
475,
40,
11240
],
[
11240,
1,
421
]
],
[
[
475,
25,
828
],
[
828,
40,
421
]
],
[
[
475,
1,
1235
],
[
1235,
... | [
[
[
"Morphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydromorphone"
]
],
[
[
"Morphine",
"{u} (Compound) resembles {v} (Compound)",
"Ethylmorphine"
],
[
"Ethylmorphine",
"{u} (Compound) resembles {v} (Com... | Morphine (Compound) resembles Ethylmorphine (Compound) and Ethylmorphine (Compound) resembles Hydromorphone (Compound)
Morphine may lead to a major life threatening interaction when taken with Oxycodone and Oxycodone (Compound) resembles Hydromorphone (Compound)
Morphine (Compound) resembles Hydrocodone (Compound) and ... |
DB01142 | DB01357 | 1,264 | 890 | [
"DDInter593",
"DDInter1160"
] | Doxepin | Mestranol | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | The 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives. | Minor | 0 | [
[
[
1264,
23,
890
]
],
[
[
1264,
23,
35
],
[
35,
40,
890
]
],
[
[
1264,
62,
380
],
[
380,
40,
890
]
],
[
[
1264,
62,
559
],
[
559,
1... | [
[
[
"Doxepin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mestranol"
]
],
[
[
"Doxepin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Quinestrol"
],
[
"Quines... | Doxepin may cause a minor interaction that can limit clinical effects when taken with Quinestrol and Quinestrol (Compound) resembles Mestranol (Compound)
Doxepin may cause a minor interaction that can limit clinical effects when taken with Conjugated estrogens and Conjugated estrogens (Compound) resembles Mestranol (Co... |
DB00363 | DB00731 | 695 | 1,144 | [
"DDInter419",
"DDInter1269"
] | Clozapine | Nateglinide | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Moderate | 1 | [
[
[
695,
24,
1144
]
],
[
[
695,
64,
168
],
[
168,
24,
1144
]
],
[
[
695,
6,
6017
],
[
6017,
45,
1144
]
],
[
[
695,
24,
609
],
[
609,
... | [
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
]
],
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bortezomib"
],
[
"Bortezomib"... | Clozapine may lead to a major life threatening interaction when taken with Bortezomib and Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide
Clozapine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Nateglinide (Compound)
Clozapine may cause a moderate in... |
DB00593 | DB12500 | 1,464 | 283 | [
"DDInter695",
"DDInter714"
] | Ethosuximide | Fedratinib | An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures. | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
1464,
24,
283
]
],
[
[
1464,
24,
351
],
[
351,
23,
283
]
],
[
[
1464,
24,
1419
],
[
1419,
24,
283
]
],
[
[
1464,
63,
600
],
[
600,
... | [
[
[
"Ethosuximide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Ethosuximide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
],
... | Ethosuximide may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Ribociclib may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Ethosuximide may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatin... |
DB01591 | DB11110 | 667 | 603 | [
"DDInter1696",
"DDInter1115"
] | Solifenacin | Magnesium citrate | Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004. | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
667,
24,
603
]
],
[
[
667,
64,
57
],
[
57,
24,
603
]
],
[
[
667,
24,
1616
],
[
1616,
24,
603
]
],
[
[
667,
63,
1151
],
[
1151,
2... | [
[
[
"Solifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Solifenacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
[
... | Solifenacin may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Solifenacin may cause a moderate interaction that could exacerbate diseases when taken with Histrelin and H... |
DB01088 | DB10897 | 714 | 539 | [
"DDInter908",
"DDInter291"
] | Iloprost | Capsicum | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Capsicum (Chili pepper) allergenic extract is used in allergenic testing. | Minor | 0 | [
[
[
714,
23,
539
]
],
[
[
714,
63,
702
],
[
702,
23,
539
]
],
[
[
714,
64,
553
],
[
553,
23,
539
]
],
[
[
714,
24,
578
],
[
578,
23,... | [
[
[
"Iloprost",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
]
],
[
[
"Iloprost",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anagrelide"
],
[
"Ana... | Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Anagrelide and Anagrelide may cause a minor interaction that can limit clinical effects when taken with Capsicum
Iloprost may lead to a major life threatening interaction when taken with Fondaparinux and Fondaparinux may cause a mi... |
DB01097 | DB12141 | 1,377 | 971 | [
"DDInter1033",
"DDInter817"
] | Leflunomide | Gilteritinib | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Major | 2 | [
[
[
1377,
25,
971
]
],
[
[
1377,
63,
112
],
[
112,
23,
971
]
],
[
[
1377,
25,
72
],
[
72,
24,
971
]
],
[
[
1377,
64,
700
],
[
700,
2... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gilteritinib"
]
],
[
[
"Leflunomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
"Met... | Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Leflunomide may lead to a major life threatening interaction when taken with Eltrombopag and Eltrombopag ... |
DB00536 | DB00572 | 1,225 | 85 | [
"DDInter848",
"DDInter136"
] | Guanidine | Atropine | A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatmen... | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Moderate | 1 | [
[
[
1225,
24,
85
]
],
[
[
1225,
63,
19
],
[
19,
24,
85
]
],
[
[
1225,
21,
28722
],
[
28722,
60,
85
]
],
[
[
1225,
24,
1511
],
[
1511,
... | [
[
[
"Guanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atropine"
]
],
[
[
"Guanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
[
... | Guanidine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Atropine
Guanidine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Atropine (Compound)
Guanid... |
DB09237 | DB11348 | 1,586 | 1,065 | [
"DDInter1045",
"DDInter279"
] | Levamlodipine | Calcium Phosphate | Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], an antihypertensive medication. Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. This medication was first marketed in Russia and India before being granted FDA approval. The names S-amlod... | Calcium phosphate is typically available as an over the counter supplement, antacid, or as an added ingredient in some toothpastes [FDA Label] . | Moderate | 1 | [
[
[
1586,
24,
1065
]
],
[
[
1586,
63,
803
],
[
803,
24,
943
],
[
943,
63,
1065
]
],
[
[
1586,
63,
803
],
[
803,
63,
1014
],
[
1014,
24,
... | [
[
[
"Levamlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium Phosphate"
]
],
[
[
"Levamlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium chlori... | Levamlodipine may cause a moderate interaction that could exacerbate diseases when taken with Calcium chloride and Calcium chloride may cause a moderate interaction that could exacerbate diseases when taken with Sarecycline and Sarecycline may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB05239 | DB10315 | 866 | 1,137 | [
"DDInter425",
"DDInter1127"
] | Cobimetinib | Measles virus vaccine live attenuated | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
866,
25,
1137
]
],
[
[
866,
64,
581
],
[
581,
25,
1137
]
],
[
[
866,
25,
384
],
[
384,
25,
1137
]
],
[
[
866,
63,
1101
],
[
1101,
... | [
[
[
"Cobimetinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Cobimetinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Infliximab"
],
[
... | Cobimetinib may lead to a major life threatening interaction when taken with Infliximab and Infliximab may lead to a major life threatening interaction when taken with Measles virus vaccine live attenuated
Cobimetinib may lead to a major life threatening interaction when taken with Idelalisib and Idelalisib may lead to... |
DB00603 | DB14730 | 303 | 1,412 | [
"DDInter1137",
"DDInter264"
] | Medroxyprogesterone acetate | Calaspargase pegol | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
303,
24,
1412
]
],
[
[
303,
24,
159
],
[
159,
24,
1412
]
],
[
[
303,
64,
640
],
[
640,
24,
1412
]
],
[
[
303,
63,
1647
],
[
1647,
... | [
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken wit... | Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Medroxyprogesterone acetate may lead to a major life threatening interaction when... |
DB00092 | DB12159 | 58 | 12 | [
"DDInter40",
"DDInter609"
] | Alefacept | Dupilumab | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Dupilumab is a fully human monoclonal antibody of the immunoglobulin G4 subclass that binds to the interleukin-4 (IL-4) receptor, inhibiting the receptor signaling pathways. As an interleukin-4 receptor alpha antagonist, dupilumab inhibits the signaling of pro-inflammatory cytokines, called interleukins (IL), that indu... | Moderate | 1 | [
[
[
58,
24,
12
]
],
[
[
58,
23,
1461
],
[
1461,
23,
12
]
],
[
[
58,
63,
599
],
[
599,
24,
12
]
],
[
[
58,
24,
1136
],
[
1136,
24,
... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dupilumab"
]
],
[
[
"Alefacept",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
"V... | Alefacept may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Dupilumab
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab and Alemtuzumab ma... |
DB00798 | DB05260 | 1,132 | 1,329 | [
"DDInter815",
"DDInter804"
] | Gentamicin | Gallium nitrate | Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negat... | Gallium nitrate is a nitrate salt of , a heavy metal that has been used as a diagnostic agent. Gallium nitrate is reported to possess antiresorptive and hypocalcemic effects on bone. GANITE, a product of gallium nitrate previously used to treat cancer-related hypercalcemia, was discontinued from marketing in the US for... | Major | 2 | [
[
[
1132,
25,
1329
]
],
[
[
1132,
21,
29035
],
[
29035,
60,
1329
]
],
[
[
1132,
63,
1555
],
[
1555,
24,
1329
]
],
[
[
1132,
24,
712
],
[
7... | [
[
[
"Gentamicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gallium nitrate"
]
],
[
[
"Gentamicin",
"{u} (Compound) causes {v} (Side Effect)",
"Hearing impaired"
],
[
"Hearing impaired",
"{u} (Side Effect) is ... | Gentamicin (Compound) causes Hearing impaired (Side Effect) and Hearing impaired (Side Effect) is caused by Gallium nitrate (Compound)
Gentamicin may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may cause a moderate interaction that could exacerbate diseases wh... |
DB00863 | DB11703 | 1,194 | 405 | [
"DDInter1568",
"DDInter9"
] | Ranitidine | Acalabrutinib | Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as [cimetidine] and [famotidine]. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.[A176759,L10818]... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Moderate | 1 | [
[
[
1194,
24,
405
]
],
[
[
1194,
23,
1384
],
[
1384,
24,
405
]
],
[
[
1194,
24,
478
],
[
478,
24,
405
]
],
[
[
1194,
25,
1250
],
[
1250,
... | [
[
[
"Ranitidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Ranitidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magaldrate"
],
[
... | Ranitidine may cause a minor interaction that can limit clinical effects when taken with Magaldrate and Magaldrate may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Ranitidine may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Niloti... |
DB01319 | DB08870 | 34 | 850 | [
"DDInter777",
"DDInter228"
] | Fosamprenavir | Brentuximab vedotin | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
34,
24,
850
]
],
[
[
34,
63,
1142
],
[
1142,
24,
850
]
],
[
[
34,
64,
134
],
[
134,
24,
850
]
],
[
[
34,
25,
1468
],
[
1468,
63,... | [
[
[
"Fosamprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Fosamprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orlistat"
... | Fosamprenavir may cause a moderate interaction that could exacerbate diseases when taken with Orlistat and Orlistat may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Fosamprenavir may lead to a major life threatening interaction when taken with Vinorelbine and Vinorelbi... |
DB06212 | DB08901 | 165 | 1,468 | [
"DDInter1833",
"DDInter1492"
] | Tolvaptan | Ponatinib | Tolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009. | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
165,
24,
1468
]
],
[
[
165,
63,
478
],
[
478,
24,
1468
]
],
[
[
165,
6,
4973
],
[
4973,
45,
1468
]
],
[
[
165,
21,
28883
],
[
28883,
... | [
[
[
"Tolvaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Tolvaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
... | Tolvaptan may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Tolvaptan (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Ponatinib (Compound)
Tolvaptan (Compound) cause... |
DB00196 | DB08865 | 600 | 1,593 | [
"DDInter743",
"DDInter448"
] | Fluconazole | Crizotinib | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Major | 2 | [
[
[
600,
25,
1593
]
],
[
[
600,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
600,
18,
7436
],
[
7436,
46,
1593
]
],
[
[
600,
7,
7885
],
[
7885,
... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
]
],
[
[
"Fluconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Crizo... | Fluconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Fluconazole (Compound) downregulates WFS1 (Gene) and WFS1 (Gene) is upregulated by Crizotinib (Compound)
Fluconazole (Compound) upregulates MELK (Gene) and MELK (Gene) is downregulated by Crizotinib (Compound)
Fluconazole (Co... |
DB00073 | DB10583 | 1,394 | 949 | [
"DDInter1608",
"DDInter415"
] | Rituximab | Clostridium tetani toxoid antigen (formaldehyde inactivated) | Rituximab is a genetically engineered chimeric murine/human monoclonal antibody directed against the CD20 antigen found on the surface of normal and malignant B lymphocytes. The antibody is an IgG1 kappa immunoglobulin containing murine light and heavy-chain variable region sequences and human constant region sequences... | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Moderate | 1 | [
[
[
1394,
24,
949
]
],
[
[
1394,
25,
1377
],
[
1377,
24,
949
]
],
[
[
1394,
24,
58
],
[
58,
24,
949
]
],
[
[
1394,
25,
1259
],
[
1259,
... | [
[
[
"Rituximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formaldehyde inactivated)"
]
],
[
[
"Rituximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Rituximab may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated)
Rituximab may cause a moderate interaction that could exacerbate diseases wh... |
DB00434 | DB00915 | 13 | 1,170 | [
"DDInter459",
"DDInter60"
] | Cyproheptadine | Amantadine | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesi... | Moderate | 1 | [
[
[
13,
24,
1170
]
],
[
[
13,
6,
2250
],
[
2250,
45,
1170
]
],
[
[
13,
7,
7273
],
[
7273,
46,
1170
]
],
[
[
13,
21,
28662
],
[
28662,
... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amantadine"
]
],
[
[
"Cyproheptadine",
"{u} (Compound) binds {v} (Gene)",
"DRD2"
],
[
"DRD2",
"{u} (Gene) is bound by {v} (Compoun... | Cyproheptadine (Compound) binds DRD2 (Gene) and DRD2 (Gene) is bound by Amantadine (Compound)
Cyproheptadine (Compound) upregulates GPATCH8 (Gene) and GPATCH8 (Gene) is upregulated by Amantadine (Compound)
Cyproheptadine (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Amantadine (Compound)
... |
DB01168 | DB01208 | 1,053 | 945 | [
"DDInter1526",
"DDInter1705"
] | Procarbazine | Sparfloxacin | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Minor | 0 | [
[
[
1053,
23,
945
]
],
[
[
1053,
62,
739
],
[
739,
1,
945
]
],
[
[
1053,
21,
28787
],
[
28787,
60,
945
]
],
[
[
1053,
63,
869
],
[
869,
... | [
[
[
"Procarbazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sparfloxacin"
]
],
[
[
"Procarbazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lomefloxacin"
],
... | Procarbazine may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Sparfloxacin (Compound)
Procarbazine (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Sparfloxacin (Compound)
Procarbazine may cause a moderat... |
DB00241 | DB00916 | 288 | 112 | [
"DDInter257",
"DDInter1202"
] | Butalbital | Metronidazole | Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervou... | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Moderate | 1 | [
[
[
288,
24,
112
]
],
[
[
288,
24,
458
],
[
458,
40,
112
]
],
[
[
288,
23,
752
],
[
752,
23,
112
]
],
[
[
288,
24,
11
],
[
11,
23,
... | [
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
]
],
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tinidazole"
],
[... | Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Tinidazole and Tinidazole (Compound) resembles Metronidazole (Compound)
Butalbital may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidine may cause a minor interaction that can lim... |
DB00526 | DB09472 | 1,555 | 1,383 | [
"DDInter1355",
"DDInter1693"
] | Oxaliplatin | Sodium sulfate | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
1555,
24,
1383
]
],
[
[
1555,
24,
609
],
[
609,
24,
1383
]
],
[
[
1555,
63,
521
],
[
521,
24,
1383
]
],
[
[
1555,
24,
1612
],
[
1612,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Goserel... |
DB00305 | DB04865 | 377 | 4 | [
"DDInter1232",
"DDInter1335"
] | Mitomycin | Omacetaxine mepesuccinate | Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of _Streptomyces caespitosus_.[L12867,A193419] It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations, RNA and protein synthesis) by cross-linking the complementary strands of th... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
377,
24,
4
]
],
[
[
377,
7,
14560
],
[
14560,
46,
4
]
],
[
[
377,
18,
10351
],
[
10351,
46,
4
]
],
[
[
377,
18,
6579
],
[
6579,
... | [
[
[
"Mitomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Mitomycin",
"{u} (Compound) upregulates {v} (Gene)",
"STAP2"
],
[
"STAP2",
"{u} (Gene) is upregula... | Mitomycin (Compound) upregulates STAP2 (Gene) and STAP2 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Mitomycin (Compound) downregulates ATF6 (Gene) and ATF6 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Mitomycin (Compound) downregulates TBC1D16 (Gene) and TBC1D16 (Gene) is downregulate... |
DB06595 | DB11915 | 1,491 | 1,293 | [
"DDInter1214",
"DDInter1909"
] | Midostaurin | Valbenazine | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Moderate | 1 | [
[
[
1491,
24,
1293
]
],
[
[
1491,
62,
112
],
[
112,
23,
1293
]
],
[
[
1491,
24,
710
],
[
710,
63,
1293
]
],
[
[
1491,
63,
521
],
[
521,
... | [
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valbenazine"
]
],
[
[
"Midostaurin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Midostaurin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Valbenazine
Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Binimetinib and ... |
DB01105 | DB14975 | 222 | 988 | [
"DDInter1665",
"DDInter1949"
] | Sibutramine | Voxelotor | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Voxelotor is a novel hemoglobin S polymerization inhibitor for the treatment of sickle cell disease. This is a genetically inherited condition most prevalent in the Middle East, Africa, and certain parts of India. Sickle cell disease can lead to excruciating pain, stroke, infection, and various other complications aris... | Minor | 0 | [
[
[
222,
23,
988
]
],
[
[
222,
63,
629
],
[
629,
24,
988
]
],
[
[
222,
24,
792
],
[
792,
24,
988
]
],
[
[
222,
62,
723
],
[
723,
24,... | [
[
[
"Sibutramine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Voxelotor"
]
],
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
],
[
... | Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Voxelotor
Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Rivaroxaban and Rivaro... |
DB00220 | DB01222 | 798 | 617 | [
"DDInter1276",
"DDInter246"
] | Nelfinavir | Budesonide | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Major | 2 | [
[
[
798,
25,
617
]
],
[
[
798,
63,
1351
],
[
1351,
1,
617
]
],
[
[
798,
24,
251
],
[
251,
1,
617
]
],
[
[
798,
25,
175
],
[
175,
1,
... | [
[
[
"Nelfinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Budesonide"
]
],
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flunisolide"
],
[
"Flunisoli... | Nelfinavir may cause a moderate interaction that could exacerbate diseases when taken with Flunisolide and Flunisolide (Compound) resembles Budesonide (Compound)
Nelfinavir may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone (Compound) resembles Budesonide (Co... |
DB00073 | DB00495 | 1,394 | 139 | [
"DDInter1608",
"DDInter1961"
] | Rituximab | Zidovudine | Rituximab is a genetically engineered chimeric murine/human monoclonal antibody directed against the CD20 antigen found on the surface of normal and malignant B lymphocytes. The antibody is an IgG1 kappa immunoglobulin containing murine light and heavy-chain variable region sequences and human constant region sequences... | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain... | Moderate | 1 | [
[
[
1394,
24,
139
]
],
[
[
1394,
24,
810
],
[
810,
63,
139
]
],
[
[
1394,
25,
980
],
[
980,
63,
139
]
],
[
[
1394,
24,
599
],
[
599,
... | [
[
[
"Rituximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zidovudine"
]
],
[
[
"Rituximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Strontium chloride Sr-89"
... | Rituximab may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89 and Strontium chloride Sr-89 may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine
Rituximab may lead to a major life threatening interaction when taken with Tocilizuma... |
DB00286 | DB00687 | 380 | 870 | [
"DDInter440",
"DDInter747"
] | Conjugated estrogens (topical) | Fludrocortisone | Estrone sodium sulfate is a steroid sulfate and an organic sodium salt. It is functionally related to an estrone. | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Moderate | 1 | [
[
[
380,
24,
870
]
],
[
[
380,
24,
1220
],
[
1220,
40,
870
]
],
[
[
380,
21,
28835
],
[
28835,
60,
870
]
],
[
[
380,
24,
1040
],
[
1040,
... | [
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
]
],
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"De... | Conjugated estrogens may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone
Conjugated estrogens may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Fludrocortisone (Compound)
Conjugated estrogens (... |
DB00363 | DB09074 | 695 | 1,362 | [
"DDInter419",
"DDInter1327"
] | Clozapine | Olaparib | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Major | 2 | [
[
[
695,
25,
1362
]
],
[
[
695,
25,
896
],
[
896,
24,
1362
]
],
[
[
695,
64,
552
],
[
552,
24,
1362
]
],
[
[
695,
62,
1684
],
[
1684,
... | [
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Olaparib"
]
],
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etoposide"
],
[
"Etoposide",
"{u} may cau... | Clozapine may lead to a major life threatening interaction when taken with Etoposide and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Clozapine may lead to a major life threatening interaction when taken with Carmustine and Carmustine may cause a moderate interactio... |
DB00047 | DB01224 | 176 | 623 | [
"DDInter932",
"DDInter1553"
] | Insulin glargine | Quetiapine | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Moderate | 1 | [
[
[
176,
24,
623
]
],
[
[
176,
24,
695
],
[
695,
1,
623
]
],
[
[
176,
24,
170
],
[
170,
63,
623
]
],
[
[
176,
24,
1130
],
[
1130,
24... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quetiapine"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clozapine"
... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Clozapine and Clozapine (Compound) resembles Quetiapine (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may cause a moderate interactio... |
DB00231 | DB01181 | 1,174 | 1,532 | [
"DDInter1761",
"DDInter906"
] | Temazepam | Ifosfamide | Temazepam, like many other similar and related benzodiazepines, acts as a gamma-aminobutyric acid (GABA) modulator and is capable of eliciting a variety of actions including sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action [A175207, A175210, F3718, F3721]. Although the chem... | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
1174,
24,
1532
]
],
[
[
1174,
6,
3486
],
[
3486,
45,
1532
]
],
[
[
1174,
21,
28956
],
[
28956,
60,
1532
]
],
[
[
1174,
63,
1648
],
[
1... | [
[
[
"Temazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Temazepam",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",
... | Temazepam (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Ifosfamide (Compound)
Temazepam (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Ifosfamide (Compound)
Temazepam may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and ... |
DB00069 | DB05273 | 367 | 507 | [
"DDInter946",
"DDInter1638"
] | Interferon alfacon-1 | Samarium (153Sm) lexidronam | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.Samarium ... | Major | 2 | [
[
[
367,
25,
507
]
],
[
[
367,
24,
248
],
[
248,
24,
507
]
],
[
[
367,
24,
270
],
[
270,
63,
507
]
],
[
[
367,
25,
1101
],
[
1101,
2... | [
[
[
"Interferon alfacon-1",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Samarium (153Sm) lexidronam"
]
],
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valga... | Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Valganciclovir and Valganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Samarium (153Sm) lexidronam
Interferon alfacon-1 may cause a moderate interaction that could exacerbate d... |
DB00536 | DB00981 | 1,225 | 1,528 | [
"DDInter848",
"DDInter1462"
] | Guanidine | Physostigmine | A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatmen... | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | Moderate | 1 | [
[
[
1225,
24,
1528
]
],
[
[
1225,
21,
28722
],
[
28722,
60,
1528
]
],
[
[
1225,
24,
1511
],
[
1511,
63,
1528
]
],
[
[
1225,
24,
262
],
[
2... | [
[
[
"Guanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Physostigmine"
]
],
[
[
"Guanidine",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused by... | Guanidine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Physostigmine (Compound)
Guanidine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Physostigm... |
DB00443 | DB00619 | 251 | 1,419 | [
"DDInter195",
"DDInter909"
] | Betamethasone | Imatinib | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Moderate | 1 | [
[
[
251,
24,
1419
]
],
[
[
251,
5,
11555
],
[
11555,
44,
1419
]
],
[
[
251,
6,
4973
],
[
4973,
45,
1419
]
],
[
[
251,
7,
3727
],
[
3727,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
]
],
[
[
"Betamethasone",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Di... | Betamethasone (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Imatinib (Compound)
Betamethasone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Imatinib (Compound)
Betamethasone (Compound) upregulates MAL (Gene) and MAL (Gene) is upregulated by Imatinib (Compound... |
DB00734 | DB09045 | 1,664 | 52 | [
"DDInter1605",
"DDInter607"
] | Risperidone | Dulaglutide | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and exercise in the management of 2 diabetes (T2DM). Dulaglutide was initially approved by the FDA... | Moderate | 1 | [
[
[
1664,
24,
52
]
],
[
[
1664,
24,
170
],
[
170,
23,
52
]
],
[
[
1664,
24,
609
],
[
609,
24,
52
]
],
[
[
1664,
63,
870
],
[
870,
24... | [
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dulaglutide"
]
],
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
],
... | Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may cause a minor interaction that can limit clinical effects when taken with Dulaglutide
Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and... |
DB00631 | DB01320 | 372 | 651 | [
"DDInter405",
"DDInter783"
] | Clofarabine | Fosphenytoin | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Moderate | 1 | [
[
[
372,
24,
651
]
],
[
[
372,
63,
362
],
[
362,
1,
651
]
],
[
[
372,
24,
998
],
[
998,
1,
651
]
],
[
[
372,
21,
28691
],
[
28691,
6... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
[... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Compound)
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutazone and Phenylbutazone (Compound) resembles Fosphenytoin... |
DB00810 | DB04843 | 456 | 1,511 | [
"DDInter211",
"DDInter1149"
] | Biperiden | Mepenzolate | A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine. | Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ga... | Moderate | 1 | [
[
[
456,
24,
1511
]
],
[
[
456,
24,
537
],
[
537,
24,
1511
]
],
[
[
456,
63,
262
],
[
262,
24,
1511
]
],
[
[
456,
24,
649
],
[
649,
... | [
[
[
"Biperiden",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
]
],
[
[
"Biperiden",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
],
[
... | Biperiden may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Biperiden may cause a moderate interaction that could exacerbate diseases when taken with Clidinium and Clidinium ... |
DB00635 | DB01001 | 1,573 | 688 | [
"DDInter1515",
"DDInter1632"
] | Prednisone | Salbutamol | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Minor | 0 | [
[
[
1573,
23,
688
]
],
[
[
1573,
23,
455
],
[
455,
24,
688
]
],
[
[
1573,
23,
1148
],
[
1148,
63,
688
]
],
[
[
1573,
5,
11649
],
[
11649,
... | [
[
[
"Prednisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Salbutamol"
]
],
[
[
"Prednisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Salmeterol"
],
[
... | Prednisone may cause a minor interaction that can limit clinical effects when taken with Salmeterol and Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Prednisone may cause a minor interaction that can limit clinical effects when taken with Isoprenaline and Isoprena... |
DB05679 | DB15965 | 1,683 | 1,330 | [
"DDInter1907",
"DDInter1270"
] | Ustekinumab | Naxitamab | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Naxitamab (humanized 3F8, hu3F8) is an IgG1 monoclonal antibody directed against the oncofetal differentiation antigen GD2 disialoganglioside.[L24454,A224604] Normally expressed during fetal development and in mature neurons, pain fibers, and skin cells, GD2 constitutes a highly efficient target in the treatment of neu... | Moderate | 1 | [
[
[
1683,
24,
1330
]
],
[
[
1683,
23,
1193
],
[
1193,
23,
1330
]
],
[
[
1683,
63,
1532
],
[
1532,
24,
1330
]
],
[
[
1683,
24,
259
],
[
259... | [
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naxitamab"
]
],
[
[
"Ustekinumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[... | Ustekinumab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Naxitamab
Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and I... |
DB00341 | DB01202 | 1,242 | 1,435 | [
"DDInter343",
"DDInter1046"
] | Cetirizine | Levetiracetam | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders. It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs).[L8606,L8600,L8615] Levetiracetam poss... | Moderate | 1 | [
[
[
1242,
24,
1435
]
],
[
[
1242,
21,
28769
],
[
28769,
60,
1435
]
],
[
[
1242,
74,
701
],
[
701,
24,
1435
]
],
[
[
1242,
63,
475
],
[
475... | [
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levetiracetam"
]
],
[
[
"Cetirizine",
"{u} (Compound) causes {v} (Side Effect)",
"Feeling abnormal"
],
[
"Feeling abnormal",
"{u} (Sid... | Cetirizine (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Levetiracetam (Compound)
Cetirizine (Compound) resembles Clemastine (Compound) and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a ... |
DB00065 | DB00515 | 581 | 589 | [
"DDInter923",
"DDInter387"
] | Infliximab | Cisplatin | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Major | 2 | [
[
[
581,
25,
589
]
],
[
[
581,
24,
949
],
[
949,
63,
589
]
],
[
[
581,
25,
1468
],
[
1468,
63,
589
]
],
[
[
581,
24,
58
],
[
58,
24,... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cisplatin"
]
],
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formalde... | Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated) and Clostridium tetani toxoid antigen (formaldehyde inactivated) may cause a moderate interaction that could exacerbate diseases when taken with Cisplatin
Infliximab ma... |
DB00307 | DB06589 | 1,101 | 1,250 | [
"DDInter202",
"DDInter1400"
] | Bexarotene | Pazopanib | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
1101,
24,
1250
]
],
[
[
1101,
6,
8374
],
[
8374,
45,
1250
]
],
[
[
1101,
21,
29203
],
[
29203,
60,
1250
]
],
[
[
1101,
24,
307
],
[
30... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Bexarotene",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Bexarotene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Pazopanib (Compound)
Bexarotene (Compound) causes Aspartate aminotransferase increased (Side Effect) and Aspartate aminotransferase increased (Side Effect) is caused by Pazopanib (Compound)
Bexarotene may cause a moderate interaction that could exa... |
DB00014 | DB13074 | 521 | 877 | [
"DDInter839",
"DDInter1110"
] | Goserelin | Macimorelin | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Major | 2 | [
[
[
521,
25,
877
]
],
[
[
521,
23,
112
],
[
112,
23,
877
]
],
[
[
521,
24,
673
],
[
673,
24,
877
]
],
[
[
521,
24,
485
],
[
485,
25,... | [
[
[
"Goserelin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Macimorelin"
]
],
[
[
"Goserelin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidaz... | Goserelin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Aripiprazole and Ari... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.