drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB08932 | DB09280 | 1,398 | 1,604 | [
"DDInter1111",
"DDInter1101"
] | Macitentan | Lumacaftor | Macitentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension. It was first approved by the FDA in 2013. Macitentan differs from its predecessor [bosentan] due to its lower risk of hepatotoxicity. | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Major | 2 | [
[
[
1398,
25,
1604
]
],
[
[
1398,
24,
159
],
[
159,
64,
1604
]
],
[
[
1398,
63,
478
],
[
478,
25,
1604
]
],
[
[
1398,
24,
951
],
[
951,
... | [
[
[
"Macitentan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lumacaftor"
]
],
[
[
"Macitentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
[
"Larotre... | Macitentan may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may lead to a major life threatening interaction when taken with Lumacaftor
Macitentan may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may le... |
DB00857 | DB01072 | 1,387 | 915 | [
"DDInter1768",
"DDInter129"
] | Terbinafine | Atazanavir | Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epox... | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Minor | 0 | [
[
[
1387,
23,
915
]
],
[
[
1387,
6,
6017
],
[
6017,
45,
915
]
],
[
[
1387,
21,
28678
],
[
28678,
60,
915
]
],
[
[
1387,
62,
1684
],
[
1684... | [
[
[
"Terbinafine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Atazanavir"
]
],
[
[
"Terbinafine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",... | Terbinafine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Atazanavir (Compound)
Terbinafine (Compound) causes Hepatocellular injury (Side Effect) and Hepatocellular injury (Side Effect) is caused by Atazanavir (Compound)
Terbinafine may cause a minor interaction that can limit clinical effects when taken... |
DB11837 | DB14723 | 1,297 | 159 | [
"DDInter1351",
"DDInter1026"
] | Osilodrostat | Larotrectinib | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
1297,
24,
159
]
],
[
[
1297,
62,
222
],
[
222,
23,
159
]
],
[
[
1297,
23,
907
],
[
907,
23,
159
]
],
[
[
1297,
63,
479
],
[
479,
... | [
[
[
"Osilodrostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Osilodrostat",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sibutramine"
],
... | Osilodrostat may cause a minor interaction that can limit clinical effects when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Osilodrostat may cause a minor interaction that can limit clinical effects when taken with Doravirine and Dor... |
DB00563 | DB00948 | 663 | 1,681 | [
"DDInter1174",
"DDInter1207"
] | Methotrexate | Mezlocillin | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Semisynthetic ampicillin-derived acylureido penicillin. It has been proposed for infections with certain anaerobes and may be useful in inner ear, bile, and CNS infections. | Major | 2 | [
[
[
663,
25,
1681
]
],
[
[
663,
64,
916
],
[
916,
1,
1681
]
],
[
[
663,
25,
514
],
[
514,
1,
1681
]
],
[
[
663,
24,
609
],
[
609,
62... | [
[
[
"Methotrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mezlocillin"
]
],
[
[
"Methotrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dicloxacillin"
],
[
"Dicloxacillin",
... | Methotrexate may lead to a major life threatening interaction when taken with Dicloxacillin and Dicloxacillin (Compound) resembles Mezlocillin (Compound)
Methotrexate may lead to a major life threatening interaction when taken with Benzylpenicillin and Benzylpenicillin (Compound) resembles Mezlocillin (Compound)
Methot... |
DB00758 | DB08899 | 1,347 | 129 | [
"DDInter413",
"DDInter649"
] | Clopidogrel | Enzalutamide | Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recen... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
1347,
24,
129
]
],
[
[
1347,
6,
8374
],
[
8374,
45,
129
]
],
[
[
1347,
21,
28703
],
[
28703,
60,
129
]
],
[
[
1347,
64,
529
],
[
529,
... | [
[
[
"Clopidogrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Clopidogrel",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Clopidogrel (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Clopidogrel (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Enzalutamide (Compound)
Clopidogrel may lead to a major life threatening interaction when taken with Fluvoxamine and Fluvoxamine m... |
DB01097 | DB14962 | 1,377 | 1,363 | [
"DDInter1033",
"DDInter1847"
] | Leflunomide | Trastuzumab deruxtecan | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Trastuzumab deruxtecan is a HER2-directed antibody attached to a topoisomerase inhibitor that is approved for use in certain types of treatment-resistant HER2-positive cancers. It is classified as an antibody-drug conjugate. The cleavable peptide linker used to bind the antibody and drug in this product distinguishes i... | Major | 2 | [
[
[
1377,
25,
1363
]
],
[
[
1377,
24,
1430
],
[
1430,
24,
1363
]
],
[
[
1377,
25,
384
],
[
384,
24,
1363
]
],
[
[
1377,
64,
599
],
[
599,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trastuzumab deruxtecan"
]
],
[
[
"Leflunomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
],
[
... | Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab deruxtecan
Leflunomide may lead to a major life threatening interaction when taken with Idelalisib and Ide... |
DB06637 | DB09074 | 1,109 | 1,362 | [
"DDInter468",
"DDInter1327"
] | Dalfampridine | Olaparib | Dalfampridine is a potassium channel blocker used to help multiple sclerosis patients walk. This is the first drug that was specifically approved to help with mobility in these patients. FDA approved on January 22, 2010. | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
1109,
24,
1362
]
],
[
[
1109,
24,
1619
],
[
1619,
63,
1362
]
],
[
[
1109,
63,
752
],
[
752,
24,
1362
]
],
[
[
1109,
64,
593
],
[
593,
... | [
[
[
"Dalfampridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Dalfampridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
],
[... | Dalfampridine may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Dalfampridine may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cime... |
DB01043 | DB01619 | 108 | 830 | [
"DDInter1146",
"DDInter1441"
] | Memantine | Phenindamine | Initially approved by the FDA in 2013, memantine is an N-methyl-D-aspartate (NMDA) receptor antagonist used in the management of Alzheimer's Disease (AD). It is different from many other Alzheimer's Disease medications, as it works by a different mechanism than the cholinesterase enzyme inhibitors normally employed in ... | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Moderate | 1 | [
[
[
108,
24,
830
]
],
[
[
108,
24,
537
],
[
537,
40,
830
]
],
[
[
108,
63,
1219
],
[
1219,
40,
830
]
],
[
[
108,
63,
13
],
[
13,
24,... | [
[
[
"Memantine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
]
],
[
[
"Memantine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
],
[
... | Memantine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) resembles Phenindamine (Compound)
Memantine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine and Azatadine (Compound) resembles Phenindamine (Compound)
Me... |
DB01309 | DB06335 | 1,254 | 761 | [
"DDInter933",
"DDInter1646"
] | Insulin glulisine | Saxagliptin | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
1254,
24,
761
]
],
[
[
1254,
62,
1103
],
[
1103,
23,
761
]
],
[
[
1254,
24,
1491
],
[
1491,
63,
761
]
],
[
[
1254,
63,
1577
],
[
1577,... | [
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Insulin glulisine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
... | Insulin glulisine may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Saxagliptin
Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Midostauri... |
DB00637 | DB00850 | 1,557 | 1,630 | [
"DDInter128",
"DDInter1432"
] | Astemizole | Perphenazine | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Moderate | 1 | [
[
[
1557,
24,
1630
]
],
[
[
1557,
63,
252
],
[
252,
40,
1630
]
],
[
[
1557,
24,
827
],
[
827,
40,
1630
]
],
[
[
1557,
25,
684
],
[
684,
... | [
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perphenazine"
]
],
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyzine"
],
[... | Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyzine and Hydroxyzine (Compound) resembles Perphenazine (Compound)
Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Trazodone and Trazodone (Compound) resembles Perphenazine (Compou... |
DB01246 | DB08883 | 820 | 1,597 | [
"DDInter45",
"DDInter1428"
] | Alimemazine | Perampanel | A phenothiazine derivative that is used as an antipruritic. | Perampanel is a noncompetitive AMPA glutamate receptor antagonist. It is marketed under the name Fycompa™ and is indicated as an adjunct in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures. The FDA label includes an important black-boxed warning ... | Moderate | 1 | [
[
[
820,
24,
1597
]
],
[
[
820,
63,
609
],
[
609,
23,
1597
]
],
[
[
820,
63,
100
],
[
100,
24,
1597
]
],
[
[
820,
40,
649
],
[
649,
... | [
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perampanel"
]
],
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
],
... | Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Perampanel
Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Bromphenirami... |
DB00529 | DB00889 | 789 | 1,133 | [
"DDInter779",
"DDInter840"
] | Foscarnet | Granisetron | An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV. | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Moderate | 1 | [
[
[
789,
24,
1133
]
],
[
[
789,
21,
28691
],
[
28691,
60,
1133
]
],
[
[
789,
23,
112
],
[
112,
62,
1133
]
],
[
[
789,
24,
1213
],
[
1213,
... | [
[
[
"Foscarnet",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Granisetron"
]
],
[
[
"Foscarnet",
"{u} (Compound) causes {v} (Side Effect)",
"Somnolence"
],
[
"Somnolence",
"{u} (Side Effect) is cau... | Foscarnet (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Granisetron (Compound)
Foscarnet may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Gran... |
DB00900 | DB08889 | 45 | 350 | [
"DDInter544",
"DDInter299"
] | Didanosine | Carfilzomib | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-termi... | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Moderate | 1 | [
[
[
45,
24,
350
]
],
[
[
45,
21,
28762
],
[
28762,
60,
350
]
],
[
[
45,
63,
482
],
[
482,
24,
350
]
],
[
[
45,
24,
310
],
[
310,
24,... | [
[
[
"Didanosine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carfilzomib"
]
],
[
[
"Didanosine",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is cause... | Didanosine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Carfilzomib (Compound)
Didanosine may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine and Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Carfilzo... |
DB06717 | DB11828 | 875 | 1,406 | [
"DDInter778",
"DDInter1281"
] | Fosaprepitant | Neratinib | Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment. | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Major | 2 | [
[
[
875,
25,
1406
]
],
[
[
875,
25,
1135
],
[
1135,
23,
1406
]
],
[
[
875,
63,
392
],
[
392,
24,
1406
]
],
[
[
875,
24,
1499
],
[
1499,
... | [
[
[
"Fosaprepitant",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Neratinib"
]
],
[
[
"Fosaprepitant",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u... | Fosaprepitant may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Neratinib
Fosaprepitant may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a... |
DB01142 | DB12332 | 1,264 | 1,619 | [
"DDInter593",
"DDInter1626"
] | Doxepin | Rucaparib | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
1264,
24,
1619
]
],
[
[
1264,
64,
222
],
[
222,
23,
1619
]
],
[
[
1264,
63,
307
],
[
307,
23,
1619
]
],
[
[
1264,
24,
271
],
[
271,
... | [
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Doxepin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
],
[
"Sibutramine",
... | Doxepin may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil may cause a minor i... |
DB10276 | DB11703 | 1,624 | 405 | [
"DDInter1623",
"DDInter9"
] | Rotavirus vaccine | Acalabrutinib | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Major | 2 | [
[
[
1624,
25,
405
]
],
[
[
1624,
64,
58
],
[
58,
24,
405
]
],
[
[
1624,
25,
1619
],
[
1619,
63,
405
]
],
[
[
1624,
64,
384
],
[
384,
... | [
[
[
"Rotavirus vaccine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Rotavirus vaccine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alefacept"
],
[
"Alefacept... | Rotavirus vaccine may lead to a major life threatening interaction when taken with Alefacept and Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Rotavirus vaccine may lead to a major life threatening interaction when taken with Rucaparib and Rucaparib may cause a ... |
DB06176 | DB06589 | 1,342 | 1,250 | [
"DDInter1616",
"DDInter1400"
] | Romidepsin | Pazopanib | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
1342,
24,
1250
]
],
[
[
1342,
62,
1247
],
[
1247,
23,
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]
],
[
[
1342,
63,
479
],
[
479,
23,
1250
]
],
[
[
1342,
63,
1630
],
[
1630... | [
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Romidepsin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[... | Romidepsin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Pazopanib
Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and ... |
DB00188 | DB00307 | 168 | 1,101 | [
"DDInter222",
"DDInter202"
] | Bortezomib | Bexarotene | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Minor | 0 | [
[
[
168,
23,
1101
]
],
[
[
168,
5,
11555
],
[
11555,
44,
1101
]
],
[
[
168,
6,
8374
],
[
8374,
45,
1101
]
],
[
[
168,
21,
28762
],
[
28762... | [
[
[
"Bortezomib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bexarotene"
]
],
[
[
"Bortezomib",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease)... | Bortezomib (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Bexarotene (Compound)
Bortezomib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bexarotene (Compound)
Bortezomib (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Bexarot... |
DB01098 | DB09121 | 14 | 1,328 | [
"DDInter1622",
"DDInter140"
] | Rosuvastatin | Aurothioglucose | Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin... | Aurothioglucose, also known as gold thioglucose, was formerly used to treat rheumatoid arthritis. Contemporary research on the effect of gold salts treatment began in 1935, primarily to reduce inflammation and to slow disease progression in patients with rheumatoid arthritis . The use of gold compounds has decreased si... | Moderate | 1 | [
[
[
14,
24,
1328
]
],
[
[
14,
63,
367
],
[
367,
24,
1328
]
],
[
[
14,
24,
310
],
[
310,
24,
1328
]
],
[
[
14,
24,
148
],
[
148,
63,
... | [
[
[
"Rosuvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aurothioglucose"
]
],
[
[
"Rosuvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Interferon alfacon... | Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with Interferon alfacon-1 and Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Aurothioglucose
Rosuvastatin may cause a moderate interaction that could exacerbate diseases when tak... |
DB00047 | DB14751 | 176 | 388 | [
"DDInter932",
"DDInter1132"
] | Insulin glargine | Mecasermin rinfabate | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Mecasermin rinfabate is approved for severe primary insulin-like growth factor (IGF) deficiency or in patients with GH gene deletion who have developed antibodies to growth hormone (GH). Mecasermin rinfabate is similar to in that both drugs contain recombinant DNA origin insulin-like growth factor 1 (IGF-1). Mecasermin... | Moderate | 1 | [
[
[
176,
24,
388
]
],
[
[
176,
24,
877
],
[
877,
24,
388
]
],
[
[
176,
24,
877
],
[
877,
63,
1179
],
[
1179,
24,
388
]
],
[
[
176,
2... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mecasermin rinfabate"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Macim... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Macimorelin and Macimorelin may cause a moderate interaction that could exacerbate diseases when taken with Mecasermin rinfabate
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00443 | DB11952 | 251 | 800 | [
"DDInter195",
"DDInter612"
] | Betamethasone | Duvelisib | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Moderate | 1 | [
[
[
251,
24,
800
]
],
[
[
251,
24,
663
],
[
663,
24,
800
]
],
[
[
251,
24,
270
],
[
270,
63,
800
]
],
[
[
251,
63,
66
],
[
66,
24,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
]
],
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
],
... | Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib
Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab ... |
DB00346 | DB11978 | 472 | 124 | [
"DDInter44",
"DDInter822"
] | Alfuzosin | Glasdegib | Benign prostatic hyperplasia (BPH) refers to a benign growth or hyperplasia of the prostate and leads to lower urinary tract symptoms in men, such as urgency, frequency and changes to urine flow. The prevalence of BPH is as high as 50%-60% for males in their 60's, and this prevalence increases to 80%-90% of those over ... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
472,
24,
124
]
],
[
[
472,
23,
112
],
[
112,
23,
124
]
],
[
[
472,
63,
475
],
[
475,
24,
124
]
],
[
[
472,
24,
79
],
[
79,
24,
... | [
[
[
"Alfuzosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Alfuzosin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Alfuzosin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Alfuzosin may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine ... |
DB01267 | DB11113 | 519 | 657 | [
"DDInter1381",
"DDInter307"
] | Paliperidone | Castor oil | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of , which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic... | Moderate | 1 | [
[
[
519,
24,
657
]
],
[
[
519,
24,
927
],
[
927,
63,
657
]
],
[
[
519,
24,
1491
],
[
1491,
24,
657
]
],
[
[
519,
25,
985
],
[
985,
2... | [
[
[
"Paliperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Castor oil"
]
],
[
[
"Paliperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
],
... | Paliperidone may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Castor oil
Paliperidone may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin and... |
DB00182 | DB00857 | 80 | 1,387 | [
"DDInter84",
"DDInter1768"
] | Amphetamine | Terbinafine | Amphetamine, a compound discovered over 100 years ago, is one of the more restricted controlled drugs. It was previously used for a large variety of conditions and this changed until this point where its use is highly restricted. Amphetamine, with the chemical formula alpha-methylphenethylamine, was discovered in 1910 ... | Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epox... | Moderate | 1 | [
[
[
80,
24,
1387
]
],
[
[
80,
6,
12523
],
[
12523,
45,
1387
]
],
[
[
80,
21,
28882
],
[
28882,
60,
1387
]
],
[
[
80,
24,
820
],
[
820,
... | [
[
[
"Amphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Terbinafine"
]
],
[
[
"Amphetamine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound... | Amphetamine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Terbinafine (Compound)
Amphetamine (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Terbinafine (Compound)
Amphetamine may cause a moderate interaction that could exacerbate disea... |
DB01048 | DB08870 | 764 | 850 | [
"DDInter1",
"DDInter228"
] | Abacavir | Brentuximab vedotin | Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. Chemically, it is a synthetic carbocyclic nucleoside and is the enantiomer with 1S, 4R absolute configuration on the cyclopentene ring. In vivo, abacavir sulfate dissociates to its free base, abacavir. | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
764,
24,
850
]
],
[
[
764,
63,
267
],
[
267,
24,
850
]
],
[
[
764,
24,
1142
],
[
1142,
24,
850
]
],
[
[
764,
24,
1618
],
[
1618,
... | [
[
[
"Abacavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Abacavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
],
... | Abacavir may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Abacavir may cause a moderate interaction that could exacerbate diseases when taken with Orlistat and Orl... |
DB00200 | DB09420 | 204 | 1,074 | [
"DDInter891",
"DDInter953"
] | Hydroxocobalamin | Iodide I-123 | Hydroxocobalamin, also known as vitamin B12a and hydroxycobalamin, is an injectable form of vitamin B 12 that has been used therapeutically to treat vitamin B 12 deficiency. It is also used in cyanide poisoning, Leber's optic atrophy, and toxic amblyopia. | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Moderate | 1 | [
[
[
204,
24,
1074
]
],
[
[
204,
21,
28741
],
[
28741,
60,
1413
],
[
1413,
24,
1074
]
],
[
[
204,
24,
57
],
[
57,
62,
1247
],
[
1247,
24,... | [
[
[
"Hydroxocobalamin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
]
],
[
[
"Hydroxocobalamin",
"{u} (Compound) causes {v} (Side Effect)",
"Agitation"
],
[
"Agitation",
"{u} (Side E... | Hydroxocobalamin (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Fexofenadine (Compound) and Fexofenadine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123
Hydroxocobalamin may cause a moderate interaction that could exacerbate diseases when ... |
DB00163 | DB00262 | 1,461 | 552 | [
"DDInter1943",
"DDInter302"
] | Vitamin E | Carmustine | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogen... | Moderate | 1 | [
[
[
1461,
24,
552
]
],
[
[
1461,
24,
377
],
[
377,
63,
552
]
],
[
[
1461,
62,
1184
],
[
1184,
24,
552
]
],
[
[
1461,
23,
1531
],
[
1531,
... | [
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carmustine"
]
],
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mitomycin"
],
[
... | Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Mitomycin and Mitomycin may cause a moderate interaction that could exacerbate diseases when taken with Carmustine
Vitamin E may cause a minor interaction that can limit clinical effects when taken with Anakinra and Anakinra may c... |
DB00635 | DB01064 | 1,573 | 1,148 | [
"DDInter1515",
"DDInter987"
] | Prednisone | Isoprenaline | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Minor | 0 | [
[
[
1573,
23,
1148
]
],
[
[
1573,
23,
480
],
[
480,
24,
1148
]
],
[
[
1573,
63,
1523
],
[
1523,
24,
1148
]
],
[
[
1573,
24,
887
],
[
887,
... | [
[
[
"Prednisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Isoprenaline"
]
],
[
[
"Prednisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Formoterol"
],
[
... | Prednisone may cause a minor interaction that can limit clinical effects when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetal... |
DB09143 | DB15093 | 313 | 1,654 | [
"DDInter1701",
"DDInter1698"
] | Sonidegib | Somapacitan | Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) developed as an anticancer agent by Novartis. It was FDA approved in 2015 for the treatment of basal cell carcinoma. | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
313,
24,
1654
]
],
[
[
313,
62,
1215
],
[
1215,
24,
1654
]
],
[
[
313,
25,
351
],
[
351,
24,
1654
]
],
[
[
313,
63,
1250
],
[
1250,
... | [
[
[
"Sonidegib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Sonidegib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lansoprazole"
],
[
... | Sonidegib may cause a minor interaction that can limit clinical effects when taken with Lansoprazole and Lansoprazole may cause a moderate interaction that could exacerbate diseases when taken with Somapacitan
Sonidegib may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause... |
DB00555 | DB00563 | 706 | 663 | [
"DDInter1020",
"DDInter1174"
] | Lamotrigine | Methotrexate | Lamotrigine is an antiepileptic drug belonging in the phenyltriazine class. It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. Lamotrigine is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. It... | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Minor | 0 | [
[
[
706,
23,
663
]
],
[
[
706,
6,
4973
],
[
4973,
45,
663
]
],
[
[
706,
21,
29215
],
[
29215,
60,
663
]
],
[
[
706,
24,
1487
],
[
1487,
... | [
[
[
"Lamotrigine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Methotrexate"
]
],
[
[
"Lamotrigine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",... | Lamotrigine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Methotrexate (Compound)
Lamotrigine (Compound) causes Ecchymosis (Side Effect) and Ecchymosis (Side Effect) is caused by Methotrexate (Compound)
Lamotrigine may cause a moderate interaction that could exacerbate diseases when taken with Hydroxychlor... |
DB01142 | DB01169 | 1,264 | 57 | [
"DDInter593",
"DDInter120"
] | Doxepin | Arsenic trioxide | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Major | 2 | [
[
[
1264,
25,
57
]
],
[
[
1264,
6,
8374
],
[
8374,
45,
57
]
],
[
[
1264,
62,
1247
],
[
1247,
23,
57
]
],
[
[
1264,
63,
480
],
[
480,
... | [
[
[
"Doxepin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
]
],
[
[
"Doxepin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Arsenic... | Doxepin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Arsenic trioxide (Compound)
Doxepin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Arsenic trioxide
Doxe... |
DB00384 | DB01168 | 1,275 | 1,053 | [
"DDInter1859",
"DDInter1526"
] | Triamterene | Procarbazine | Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side. Since it a... | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Moderate | 1 | [
[
[
1275,
24,
1053
]
],
[
[
1275,
24,
848
],
[
848,
40,
1053
]
],
[
[
1275,
21,
28762
],
[
28762,
60,
1053
]
],
[
[
1275,
24,
104
],
[
104... | [
[
[
"Triamterene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
]
],
[
[
"Triamterene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
],
[... | Triamterene may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen (Compound) resembles Procarbazine (Compound)
Triamterene (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Procarbazine (Compound)
Triamterene may cause a moderate interacti... |
DB00019 | DB14962 | 1,257 | 1,363 | [
"DDInter1405",
"DDInter1847"
] | Pegfilgrastim | Trastuzumab deruxtecan | Pegfilgrastim is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (G-CSF) analogue, [filgrastim]. The drug is approved for use to decrease the incidence of infection, as manifested by febrile neutropenia, in susceptible patients with with non-myeloid cancer receiving myelosuppressive anti... | Trastuzumab deruxtecan is a HER2-directed antibody attached to a topoisomerase inhibitor that is approved for use in certain types of treatment-resistant HER2-positive cancers. It is classified as an antibody-drug conjugate. The cleavable peptide linker used to bind the antibody and drug in this product distinguishes i... | Moderate | 1 | [
[
[
1257,
24,
1363
]
],
[
[
1257,
24,
384
],
[
384,
24,
1363
]
],
[
[
1257,
25,
1064
],
[
1064,
25,
1363
]
],
[
[
1257,
24,
384
],
[
384,
... | [
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trastuzumab deruxtecan"
]
],
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisi... | Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab deruxtecan
Pegfilgrastim may lead to a major life threatening interaction when taken with Cladribine and Cla... |
DB00851 | DB10795 | 611 | 221 | [
"DDInter463",
"DDInter1486"
] | Dacarbazine | Poliovirus type 1 antigen (formaldehyde inactivated) | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
611,
24,
221
]
],
[
[
611,
64,
581
],
[
581,
24,
221
]
],
[
[
611,
63,
599
],
[
599,
24,
221
]
],
[
[
611,
24,
384
],
[
384,
24,... | [
[
[
"Dacarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Dacarbazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Dacarbazine may lead to a major life threatening interaction when taken with Infliximab and Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Dacarbazine may cause a moderate interaction that could exacerbate diseases when tak... |
DB00182 | DB06704 | 80 | 247 | [
"DDInter84",
"DDInter952"
] | Amphetamine | Iobenguane (I-131) | Amphetamine, a compound discovered over 100 years ago, is one of the more restricted controlled drugs. It was previously used for a large variety of conditions and this changed until this point where its use is highly restricted. Amphetamine, with the chemical formula alpha-methylphenethylamine, was discovered in 1910 ... | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Major | 2 | [
[
[
80,
37,
247
]
],
[
[
80,
6,
7390
],
[
7390,
45,
247
]
],
[
[
80,
21,
28787
],
[
28787,
60,
247
]
],
[
[
80,
24,
820
],
[
820,
24... | [
[
[
"Amphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v}",
"Iobenguane"
]
],
[
[
"Amphetamine",
"{u} (Compound) binds {v} (Gene)",
"SLC6... | Amphetamine may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane and Amphetamine may lead to a major life threatening interaction when taken with Iobenguane
Amphetamine (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Iobenguane (Compound)
Amphetamine (Compound) causes ... |
DB00374 | DB00780 | 1,061 | 551 | [
"DDInter1852",
"DDInter1440"
] | Treprostinil | Phenelzine | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Phenelzine, with the formula β-phenylethylhydrazine, is a monoamine oxidase inhibiting antidepressant that is effective in the treatment of panic disorder and social anxiety disorder. It was developed by Parke Davis and originally FDA approved on June 9th, 1961. It is currently approved under prescription by the name o... | Moderate | 1 | [
[
[
1061,
24,
551
]
],
[
[
1061,
24,
1161
],
[
1161,
40,
551
]
],
[
[
1061,
7,
3478
],
[
3478,
57,
551
]
],
[
[
1061,
18,
8368
],
[
8368,
... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenelzine"
]
],
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Selegiline"
],
... | Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Selegiline and Selegiline (Compound) resembles Phenelzine (Compound)
Treprostinil (Compound) upregulates RALA (Gene) and RALA (Gene) is downregulated by Phenelzine (Compound)
Treprostinil (Compound) downregulates DNTTIP2 (Gene)... |
DB00372 | DB01156 | 999 | 593 | [
"DDInter1793",
"DDInter252"
] | Thiethylperazine | Bupropion | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Major | 2 | [
[
[
999,
25,
593
]
],
[
[
999,
24,
211
],
[
211,
23,
593
]
],
[
[
999,
24,
1433
],
[
1433,
24,
593
]
],
[
[
999,
24,
1532
],
[
1532,
... | [
[
[
"Thiethylperazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bupropion"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolterodine"
],
[
... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine and Tolterodine may cause a minor interaction that can limit clinical effects when taken with Bupropion
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Doxazosin ... |
DB00033 | DB01030 | 342 | 869 | [
"DDInter949",
"DDInter1835"
] | Interferon gamma-1b | Topotecan | Human Interferon gamma-1b (140 residues), produced from E. coli. Production of Actimmune is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. Purification of the product is achieved by conventional column chromatography. The sequence ... | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Moderate | 1 | [
[
[
342,
24,
869
]
],
[
[
342,
24,
1430
],
[
1430,
63,
869
]
],
[
[
342,
24,
482
],
[
482,
24,
869
]
],
[
[
342,
25,
1064
],
[
1064,
... | [
[
[
"Interferon gamma-1b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Topotecan"
]
],
[
[
"Interferon gamma-1b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel... | Interferon gamma-1b may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Topotecan
Interferon gamma-1b may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00373 | DB06292 | 461 | 549 | [
"DDInter1809",
"DDInter474"
] | Timolol | Dapagliflozin | Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective ag... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
461,
24,
549
]
],
[
[
461,
24,
1344
],
[
1344,
40,
549
]
],
[
[
461,
6,
12523
],
[
12523,
45,
549
]
],
[
[
461,
21,
29222
],
[
29222,
... | [
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
[
... | Timolol may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Timolol (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Dapagliflozin (Compound)
Timolol (Compound) causes Hypoglycaemia (Side Effect) and Hy... |
DB01309 | DB08815 | 1,254 | 154 | [
"DDInter933",
"DDInter1104"
] | Insulin glulisine | Lurasidone | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States. | Moderate | 1 | [
[
[
1254,
24,
154
]
],
[
[
1254,
24,
1033
],
[
1033,
63,
154
]
],
[
[
1254,
24,
1446
],
[
1446,
24,
154
]
],
[
[
1254,
63,
959
],
[
959,
... | [
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurasidone"
]
],
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
... | Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and Alpelisib may cause a moderate interaction that could exacerbate diseases when taken with Lurasidone
Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Lanreotid... |
DB00637 | DB11915 | 1,557 | 1,293 | [
"DDInter128",
"DDInter1909"
] | Astemizole | Valbenazine | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Moderate | 1 | [
[
[
1557,
24,
1293
]
],
[
[
1557,
23,
112
],
[
112,
23,
1293
]
],
[
[
1557,
24,
710
],
[
710,
63,
1293
]
],
[
[
1557,
63,
521
],
[
521,
... | [
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valbenazine"
]
],
[
[
"Astemizole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Astemizole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Valbenazine
Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Binimetinib and Bi... |
DB00604 | DB01268 | 1,425 | 1,151 | [
"DDInter385",
"DDInter1731"
] | Cisapride | Sunitinib | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Major | 2 | [
[
[
1425,
25,
1151
]
],
[
[
1425,
40,
1311
],
[
1311,
1,
1151
]
],
[
[
1425,
6,
6799
],
[
6799,
45,
1151
]
],
[
[
1425,
18,
2801
],
[
2801... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sunitinib"
]
],
[
[
"Cisapride",
"{u} (Compound) resembles {v} (Compound)",
"Metoclopramide"
],
[
"Metoclopramide",
"{u} (Compound) resembles {v} (Com... | Cisapride (Compound) resembles Metoclopramide (Compound) and Metoclopramide (Compound) resembles Sunitinib (Compound)
Cisapride (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Sunitinib (Compound)
Cisapride (Compound) downregulates PUF60 (Gene) and PUF60 (Gene) is downregulated by Sunitinib (Compound)
Cisa... |
DB01050 | DB15035 | 848 | 503 | [
"DDInter900",
"DDInter1959"
] | Ibuprofen | Zanubrutinib | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Major | 2 | [
[
[
848,
25,
503
]
],
[
[
848,
24,
222
],
[
222,
24,
503
]
],
[
[
848,
63,
599
],
[
599,
24,
503
]
],
[
[
848,
62,
752
],
[
752,
24,... | [
[
[
"Ibuprofen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Ibuprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"Sibutrami... | Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab and Ale... |
DB00014 | DB01236 | 521 | 679 | [
"DDInter839",
"DDInter1664"
] | Goserelin | Sevoflurane | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 199... | Moderate | 1 | [
[
[
521,
24,
679
]
],
[
[
521,
24,
1262
],
[
1262,
40,
679
]
],
[
[
521,
21,
28751
],
[
28751,
60,
679
]
],
[
[
521,
23,
112
],
[
112,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sevoflurane"
]
],
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perflutren"
],
[
... | Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Perflutren and Perflutren (Compound) resembles Sevoflurane (Compound)
Goserelin (Compound) causes Convulsion (Side Effect) and Convulsion (Side Effect) is caused by Sevoflurane (Compound)
Goserelin may cause a minor interaction th... |
DB00307 | DB08827 | 1,101 | 990 | [
"DDInter202",
"DDInter1085"
] | Bexarotene | Lomitapide | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Major | 2 | [
[
[
1101,
25,
990
]
],
[
[
1101,
23,
1080
],
[
1080,
1,
990
]
],
[
[
1101,
6,
8374
],
[
8374,
45,
990
]
],
[
[
1101,
21,
28701
],
[
28701,... | [
[
[
"Bexarotene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomitapide"
]
],
[
[
"Bexarotene",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Conivaptan"
],
[
"Conivaptan",... | Bexarotene may cause a minor interaction that can limit clinical effects when taken with Conivaptan and Conivaptan (Compound) resembles Lomitapide (Compound)
Bexarotene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lomitapide (Compound)
Bexarotene (Compound) causes Discomfort (Side Effect) and Discomfort... |
DB00361 | DB00631 | 134 | 372 | [
"DDInter1939",
"DDInter405"
] | Vinorelbine | Clofarabine | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Moderate | 1 | [
[
[
134,
24,
372
]
],
[
[
134,
64,
1064
],
[
1064,
25,
372
]
],
[
[
134,
24,
1488
],
[
1488,
40,
372
]
],
[
[
134,
5,
11555
],
[
11555,
... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
]
],
[
[
"Vinorelbine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[
"Cladrib... | Vinorelbine may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Clofarabine
Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine and Fludarabine (Compound) resembles... |
DB00285 | DB11978 | 1,100 | 124 | [
"DDInter1927",
"DDInter822"
] | Venlafaxine | Glasdegib | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
1100,
24,
124
]
],
[
[
1100,
23,
112
],
[
112,
23,
124
]
],
[
[
1100,
24,
475
],
[
475,
24,
124
]
],
[
[
1100,
23,
752
],
[
752,
... | [
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Venlafaxine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Venlafaxine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morph... |
DB00855 | DB00903 | 213 | 1,680 | [
"DDInter72",
"DDInter686"
] | Aminolevulinic acid | Etacrynic acid | A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem] | A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as ... | Major | 2 | [
[
[
213,
25,
1680
]
],
[
[
213,
18,
3517
],
[
3517,
46,
1680
]
],
[
[
213,
7,
5998
],
[
5998,
46,
1680
]
],
[
[
213,
18,
7335
],
[
7335,
... | [
[
[
"Aminolevulinic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etacrynic acid"
]
],
[
[
"Aminolevulinic acid",
"{u} (Compound) downregulates {v} (Gene)",
"TXNRD1"
],
[
"TXNRD1",
"{u} (Gene) is upregulate... | Aminolevulinic acid (Compound) downregulates TXNRD1 (Gene) and TXNRD1 (Gene) is upregulated by Etacrynic acid (Compound)
Aminolevulinic acid (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Etacrynic acid (Compound)
Aminolevulinic acid (Compound) downregulates LIG1 (Gene) and LIG1 (Gene) is downre... |
DB08918 | DB09472 | 41 | 1,383 | [
"DDInter1059",
"DDInter1693"
] | Levomilnacipran | Sodium sulfate | Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake.[A261181, A38560] Levomilnacipran is the more active 1S,2R-enantiomer in the racemate [milnacipran].[A261181, L47956] Once administered, interc... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
41,
24,
1383
]
],
[
[
41,
64,
609
],
[
609,
24,
1383
]
],
[
[
41,
63,
1311
],
[
1311,
24,
1383
]
],
[
[
41,
1,
901
],
[
901,
24,... | [
[
[
"Levomilnacipran",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Levomilnacipran",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
],
[... | Levomilnacipran may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Levomilnacipran may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide... |
DB00704 | DB11986 | 267 | 484 | [
"DDInter1263",
"DDInter648"
] | Naltrexone | Entrectinib | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
267,
24,
484
]
],
[
[
267,
24,
1247
],
[
1247,
23,
484
]
],
[
[
267,
24,
998
],
[
998,
24,
484
]
],
[
[
267,
63,
322
],
[
322,
2... | [
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfamethoxazole"
],
... | Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Phenylbuta... |
DB00047 | DB00218 | 176 | 1,176 | [
"DDInter932",
"DDInter1247"
] | Insulin glargine | Moxifloxacin | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Major | 2 | [
[
[
176,
25,
1176
]
],
[
[
176,
25,
945
],
[
945,
40,
1176
]
],
[
[
176,
24,
549
],
[
549,
63,
1176
]
],
[
[
176,
63,
305
],
[
305,
... | [
[
[
"Insulin glargine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Moxifloxacin"
]
],
[
[
"Insulin glargine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sparfloxacin"
],
[
"Sparfloxa... | Insulin glargine may lead to a major life threatening interaction when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Moxifloxacin (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin may cause a moderate interaction t... |
DB00033 | DB08908 | 342 | 713 | [
"DDInter949",
"DDInter564"
] | Interferon gamma-1b | Dimethyl fumarate | Human Interferon gamma-1b (140 residues), produced from E. coli. Production of Actimmune is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. Purification of the product is achieved by conventional column chromatography. The sequence ... | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Moderate | 1 | [
[
[
342,
24,
713
]
],
[
[
342,
24,
4
],
[
4,
24,
713
]
],
[
[
342,
24,
270
],
[
270,
63,
713
]
],
[
[
342,
63,
305
],
[
305,
24,
... | [
[
[
"Interferon gamma-1b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Interferon gamma-1b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Om... | Interferon gamma-1b may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Interferon gamma-1b may cause a moderate interaction that could ex... |
DB01284 | DB04861 | 1,042 | 1,592 | [
"DDInter1782",
"DDInter1271"
] | Tetracosactide | Nebivolol | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than [atenolol], [propranolol], or [pindolol]. Nebivolol and... | Moderate | 1 | [
[
[
1042,
24,
1592
]
],
[
[
1042,
24,
286
],
[
286,
62,
1592
]
],
[
[
1042,
24,
1450
],
[
1450,
63,
1592
]
],
[
[
1042,
63,
1685
],
[
1685... | [
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nebivolol"
]
],
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"... | Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide and Magnesium hydroxide may cause a minor interaction that can limit clinical effects when taken with Nebivolol
Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00991 | DB11793 | 97 | 738 | [
"DDInter1358",
"DDInter1297"
] | Oxaprozin | Niraparib | Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
97,
24,
738
]
],
[
[
97,
25,
1213
],
[
1213,
24,
738
]
],
[
[
97,
64,
663
],
[
663,
24,
738
]
],
[
[
97,
63,
1578
],
[
1578,
24,... | [
[
[
"Oxaprozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Oxaprozin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
],
[
"Dasatinib",
... | Oxaprozin may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Oxaprozin may lead to a major life threatening interaction when taken with Methotrexate and Methotrexate may cause a moderate inter... |
DB00549 | DB08867 | 522 | 807 | [
"DDInter1955",
"DDInter1897"
] | Zafirlukast | Ulipristal | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Ulipristal is a selective progesterone receptor modulator used for the purposes of emergency contraception (Ella) and for the treatment of uterine fibroids (Fibristal). It is a derivative of 19-norprogesterone and has both antagonistic and partial agonist activity at the progesterone receptor. It also binds to glucocor... | Minor | 0 | [
[
[
522,
23,
807
]
],
[
[
522,
24,
723
],
[
723,
23,
807
]
],
[
[
522,
24,
1017
],
[
1017,
63,
807
]
],
[
[
522,
24,
478
],
[
478,
2... | [
[
[
"Zafirlukast",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ulipristal"
]
],
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[
... | Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a minor interaction that can limit clinical effects when taken with Ulipristal
Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlat... |
DB00197 | DB08886 | 1,324 | 637 | [
"DDInter1881",
"DDInter126"
] | Troglitazone | Asparaginase Erwinia chrysanthemi | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Asparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-aspar... | Moderate | 1 | [
[
[
1324,
24,
637
]
],
[
[
1324,
24,
392
],
[
392,
24,
637
]
],
[
[
1324,
24,
159
],
[
159,
63,
637
]
],
[
[
1324,
63,
912
],
[
912,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Erwinia chrysanthemi"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Erwinia chrysanthemi
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken w... |
DB01182 | DB08875 | 371 | 1,618 | [
"DDInter1534",
"DDInter262"
] | Propafenone | Cabozantinib | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
371,
25,
1618
]
],
[
[
371,
62,
112
],
[
112,
23,
1618
]
],
[
[
371,
63,
723
],
[
723,
24,
1618
]
],
[
[
371,
24,
384
],
[
384,
... | [
[
[
"Propafenone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Propafenone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metro... | Propafenone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Propafenone may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and ... |
DB00515 | DB00529 | 589 | 789 | [
"DDInter387",
"DDInter779"
] | Cisplatin | Foscarnet | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV. | Moderate | 1 | [
[
[
589,
24,
789
]
],
[
[
589,
21,
29785
],
[
29785,
60,
789
]
],
[
[
589,
24,
112
],
[
112,
62,
789
]
],
[
[
589,
24,
1573
],
[
1573,
... | [
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Foscarnet"
]
],
[
[
"Cisplatin",
"{u} (Compound) causes {v} (Side Effect)",
"Abscess"
],
[
"Abscess",
"{u} (Side Effect) is caused by {... | Cisplatin (Compound) causes Abscess (Side Effect) and Abscess (Side Effect) is caused by Foscarnet (Compound)
Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Foscarnet
... |
DB00662 | DB00697 | 717 | 876 | [
"DDInter1873",
"DDInter1821"
] | Trimethobenzamide | Tizanidine | Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against e... | Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury . It may also be caused by musculoskeletal injury . Regardless of the cause, muscle spasticity can be an extremely painful and debi... | Moderate | 1 | [
[
[
717,
24,
876
]
],
[
[
717,
24,
1617
],
[
1617,
1,
876
]
],
[
[
717,
63,
1020
],
[
1020,
1,
876
]
],
[
[
717,
21,
28826
],
[
28826,
... | [
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tizanidine"
]
],
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apraclonidine... | Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Apraclonidine and Apraclonidine (Compound) resembles Tizanidine (Compound)
Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Clonidine and Clonidine (Compound) resembles Tiza... |
DB00570 | DB06317 | 147 | 1,626 | [
"DDInter1936",
"DDInter630"
] | Vinblastine | Elotuzumab | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family... | Moderate | 1 | [
[
[
147,
24,
1626
]
],
[
[
147,
24,
973
],
[
973,
24,
1626
]
],
[
[
147,
63,
1463
],
[
1463,
24,
1626
]
],
[
[
147,
24,
200
],
[
200,
... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elotuzumab"
]
],
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
],
[
... | Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Elotuzumab
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Lovastatin and Lova... |
DB00207 | DB01169 | 1,570 | 57 | [
"DDInter157",
"DDInter120"
] | Azithromycin | Arsenic trioxide | Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It was initially approved by the FDA in 1991. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually tra... | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Major | 2 | [
[
[
1570,
25,
57
]
],
[
[
1570,
6,
8374
],
[
8374,
45,
57
]
],
[
[
1570,
23,
112
],
[
112,
23,
57
]
],
[
[
1570,
24,
603
],
[
603,
6... | [
[
[
"Azithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
]
],
[
[
"Azithromycin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Azithromycin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Arsenic trioxide (Compound)
Azithromycin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Arsenic trioxide
... |
DB00902 | DB00903 | 104 | 1,680 | [
"DDInter1168",
"DDInter686"
] | Methdilazine | Etacrynic acid | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as ... | Moderate | 1 | [
[
[
104,
24,
1680
]
],
[
[
104,
24,
1021
],
[
1021,
63,
1680
]
],
[
[
104,
25,
593
],
[
593,
63,
1680
]
],
[
[
104,
40,
820
],
[
820,
... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etacrynic acid"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pramlintide"
],... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Pramlintide and Pramlintide may cause a moderate interaction that could exacerbate diseases when taken with Etacrynic acid
Methdilazine may lead to a major life threatening interaction when taken with Bupropion and Bupropion ma... |
DB00619 | DB08913 | 1,419 | 1,186 | [
"DDInter909",
"DDInter1561"
] | Imatinib | Radium Ra 223 dichloride | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Radium Ra 223 Dichloride is a radiopharmaceutical containing the radioisotope radium-223 that emits short range but high linear energy alpha particles. As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas of high bone turnover as seen in bone metastases. It was first ap... | Moderate | 1 | [
[
[
1419,
24,
1186
]
],
[
[
1419,
21,
28722
],
[
28722,
60,
1186
]
],
[
[
1419,
24,
37
],
[
37,
24,
1186
]
],
[
[
1419,
63,
134
],
[
134,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Radium Ra 223 dichloride"
]
],
[
[
"Imatinib",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is ... | Imatinib (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Radium Ra 223 dichloride (Compound)
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Lomustine and Lomustine may cause a moderate interaction that could exacerbate diseases when taken with Radiu... |
DB00357 | DB06207 | 1,051 | 910 | [
"DDInter71",
"DDInter1667"
] | Aminoglutethimide | Silodosin | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Silodosin is a selective antagonist of alpha(α)-1 adrenergic receptors that binds to the α<sub>1A</sub> subtype with the highest affinity. α1-adrenergic receptors regulate smooth muscle tone in the bladder neck, prostate, and prostatic urethra: the α<sub>1A</sub> subtype accounts for approximately 75% of α1-adrenocepto... | Moderate | 1 | [
[
[
1051,
24,
910
]
],
[
[
1051,
6,
8374
],
[
8374,
45,
910
]
],
[
[
1051,
21,
28921
],
[
28921,
60,
910
]
],
[
[
1051,
24,
1220
],
[
1220... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Silodosin"
]
],
[
[
"Aminoglutethimide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v}... | Aminoglutethimide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Silodosin (Compound)
Aminoglutethimide (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Silodosin (Compound)
Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00247 | DB09073 | 1,131 | 951 | [
"DDInter1194",
"DDInter1379"
] | Methysergide | Palbociclib | An ergot derivative that is a congener of lysergic acid diethylamide. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize sero... | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Moderate | 1 | [
[
[
1131,
24,
951
]
],
[
[
1131,
24,
1476
],
[
1476,
63,
951
]
],
[
[
1131,
63,
600
],
[
600,
24,
951
]
],
[
[
1131,
24,
578
],
[
578,
... | [
[
[
"Methysergide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
]
],
[
[
"Methysergide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
],
... | Methysergide may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib
Methysergide may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and ... |
DB00347 | DB06282 | 917 | 516 | [
"DDInter1871",
"DDInter1053"
] | Trimethadione | Levocetirizine | An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378) | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
917,
24,
516
]
],
[
[
917,
63,
701
],
[
701,
24,
516
]
],
[
[
917,
24,
1614
],
[
1614,
24,
516
]
],
[
[
917,
24,
407
],
[
407,
6... | [
[
[
"Trimethadione",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Trimethadione",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
]... | Trimethadione may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine
Trimethadione may cause a moderate interaction that could exacerbate diseases when taken with Nabilone an... |
DB06168 | DB14409 | 1,531 | 1,129 | [
"DDInter281",
"DDInter867"
] | Canakinumab | Human adenovirus e serotype 4 strain cl-68578 antigen | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
1531,
24,
1129
]
],
[
[
1531,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
1531,
63,
1683
],
[
1683,
24,
1129
]
],
[
[
1531,
24,
1456
],
[
14... | [
[
[
"Canakinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Canakinumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Canakinumab may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Canakinumab may cause a moderate interaction that could exacerbate diseases when ta... |
DB00332 | DB00792 | 1,089 | 832 | [
"DDInter970",
"DDInter1878"
] | Ipratropium | Tripelennamine | Ipratropium is a quaternary ammonium derivative of [atropine] that acts as an anticholinergic agent. It is commonly administered through inhalation which allows producing a local effect without presenting a significant systemic absorption. Ipratropium as a therapeutic agent was developed by Boehringer Ingelheim and its... | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Moderate | 1 | [
[
[
1089,
24,
832
]
],
[
[
1089,
24,
100
],
[
100,
63,
832
]
],
[
[
1089,
24,
508
],
[
508,
1,
832
]
],
[
[
1089,
24,
1594
],
[
1594,
... | [
[
[
"Ipratropium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
]
],
[
[
"Ipratropium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
... | Ipratropium may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine
Ipratropium may cause a moderate interaction that could exacerbate diseases when taken with Proma... |
DB01028 | DB01250 | 1,332 | 712 | [
"DDInter1179",
"DDInter1334"
] | Methoxyflurane | Olsalazine | An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with nitrous oxide to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular... | Olsalazine is an aminosalicylate and a prodrug of [mesalamine] (5-aminosalicylic acid, 5-ASA). It was first developed for delivering mesalamine to the colon without the use of [sulfapyridine]. Olsalazine comprises two mesalamine molecules joined by an azo bridge, which is cleaved in the colon. Olsalazine is an anti-inf... | Moderate | 1 | [
[
[
1332,
24,
712
]
],
[
[
1332,
63,
50
],
[
50,
40,
712
]
],
[
[
1332,
63,
485
],
[
485,
24,
712
]
],
[
[
1332,
24,
1272
],
[
1272,
... | [
[
[
"Methoxyflurane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olsalazine"
]
],
[
[
"Methoxyflurane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfasalazine"
... | Methoxyflurane may cause a moderate interaction that could exacerbate diseases when taken with Sulfasalazine and Sulfasalazine (Compound) resembles Olsalazine (Compound)
Methoxyflurane may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine and Pentamidine may cause a moderate intera... |
DB00408 | DB00427 | 1,408 | 1,233 | [
"DDInter1099",
"DDInter1879"
] | Loxapine | Triprolidine | An antipsychotic agent used in schizophrenia. [PubChem] | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Moderate | 1 | [
[
[
1408,
24,
1233
]
],
[
[
1408,
6,
10104
],
[
10104,
45,
1233
]
],
[
[
1408,
24,
262
],
[
262,
63,
1233
]
],
[
[
1408,
1,
523
],
[
523,
... | [
[
[
"Loxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triprolidine"
]
],
[
[
"Loxapine",
"{u} (Compound) binds {v} (Gene)",
"HRH1"
],
[
"HRH1",
"{u} (Gene) is bound by {v} (Compound)",
... | Loxapine (Compound) binds HRH1 (Gene) and HRH1 (Gene) is bound by Triprolidine (Compound)
Loxapine may cause a moderate interaction that could exacerbate diseases when taken with Clidinium and Clidinium may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine
Loxapine (Compound) rese... |
DB00586 | DB08896 | 1,512 | 292 | [
"DDInter537",
"DDInter1576"
] | Diclofenac | Regorafenib | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Major | 2 | [
[
[
1512,
25,
292
]
],
[
[
1512,
6,
6017
],
[
6017,
45,
292
]
],
[
[
1512,
21,
28890
],
[
28890,
60,
292
]
],
[
[
1512,
24,
643
],
[
643,
... | [
[
[
"Diclofenac",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Regorafenib"
]
],
[
[
"Diclofenac",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
"Regora... | Diclofenac (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Regorafenib (Compound)
Diclofenac (Compound) causes Myocardial infarction (Side Effect) and Myocardial infarction (Side Effect) is caused by Regorafenib (Compound)
Diclofenac may cause a moderate interaction that could exacerbate diseases when take... |
DB05316 | DB09078 | 749 | 1,228 | [
"DDInter1467",
"DDInter1036"
] | Pimavanserin | Lenvatinib | Pimavanserin is an atypical antipsychotic indicated for the treatment of psychiatric disorders. Although the exact mechanism of action is unknown, it is thought that pimavanserin interacts with the serotonin receptors, particularly the 5-HT<sub>2A</sub> and HT<sub>2C</sub> receptors. Unlike other atypical antipsychotic... | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Moderate | 1 | [
[
[
749,
24,
1228
]
],
[
[
749,
62,
112
],
[
112,
23,
1228
]
],
[
[
749,
64,
609
],
[
609,
24,
1228
]
],
[
[
749,
63,
1264
],
[
1264,
... | [
[
[
"Pimavanserin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lenvatinib"
]
],
[
[
"Pimavanserin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Pimavanserin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lenvatinib
Pimavanserin may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromy... |
DB00916 | DB01211 | 112 | 609 | [
"DDInter1202",
"DDInter393"
] | Metronidazole | Clarithromycin | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Minor | 0 | [
[
[
112,
23,
609
]
],
[
[
112,
62,
1570
],
[
1570,
24,
609
]
],
[
[
112,
6,
8374
],
[
8374,
45,
609
]
],
[
[
112,
21,
28759
],
[
28759,
... | [
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clarithromycin"
]
],
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Azithromycin"
],
... | Metronidazole may cause a minor interaction that can limit clinical effects when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Metronidazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Clarithromycin (Compound)
Me... |
DB00443 | DB14550 | 251 | 821 | [
"DDInter195",
"DDInter803"
] | Betamethasone | Gallium chloride Ga-67 | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Gallium chloride Ga-67 is the chloride salt of a gallium radioisotope which is typically complexed with [sodium citrate] to generate [gallium citrate Ga 67], which can be used to image certain cancers and inflammatory lesions. | Moderate | 1 | [
[
[
251,
24,
821
]
],
[
[
251,
24,
663
],
[
663,
24,
821
]
],
[
[
251,
1,
1220
],
[
1220,
24,
821
]
],
[
[
251,
40,
167
],
[
167,
24... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gallium chloride Ga-67"
]
],
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrex... | Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Gallium chloride Ga-67
Betamethasone (Compound) resembles Dexamethasone (Compound) and Dexamethasone may cause a mod... |
DB00241 | DB00427 | 288 | 1,233 | [
"DDInter257",
"DDInter1879"
] | Butalbital | Triprolidine | Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervou... | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Moderate | 1 | [
[
[
288,
24,
1233
]
],
[
[
288,
1,
536
],
[
536,
24,
1233
]
],
[
[
288,
24,
104
],
[
104,
63,
1233
]
],
[
[
288,
40,
1023
],
[
1023,
... | [
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triprolidine"
]
],
[
[
"Butalbital",
"{u} (Compound) resembles {v} (Compound)",
"Secobarbital"
],
[
"Secobarbital",
"{u} may cause a m... | Butalbital (Compound) resembles Secobarbital (Compound) and Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine
Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction ... |
DB00197 | DB01132 | 1,324 | 1,130 | [
"DDInter1881",
"DDInter1472"
] | Troglitazone | Pioglitazone | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Moderate | 1 | [
[
[
1324,
24,
1130
]
],
[
[
1324,
62,
333
],
[
333,
23,
1130
]
],
[
[
1324,
24,
566
],
[
566,
23,
1130
]
],
[
[
1324,
24,
517
],
[
517,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitazone"
]
],
[
[
"Troglitazone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lipoic acid"
],
... | Troglitazone may cause a minor interaction that can limit clinical effects when taken with Lipoic acid and Lipoic acid may cause a minor interaction that can limit clinical effects when taken with Pioglitazone
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Levonorgestrel an... |
DB00656 | DB12332 | 827 | 1,619 | [
"DDInter1851",
"DDInter1626"
] | Trazodone | Rucaparib | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
827,
24,
1619
]
],
[
[
827,
25,
222
],
[
222,
23,
1619
]
],
[
[
827,
23,
112
],
[
112,
23,
1619
]
],
[
[
827,
24,
1662
],
[
1662,
... | [
[
[
"Trazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Trazodone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
],
[
"Sibutramine"... | Trazodone may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Trazodone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause... |
DB00015 | DB06228 | 582 | 792 | [
"DDInter1585",
"DDInter1609"
] | Reteplase | Rivaroxaban | Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids p... | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Major | 2 | [
[
[
582,
25,
792
]
],
[
[
582,
23,
944
],
[
944,
62,
792
]
],
[
[
582,
24,
901
],
[
901,
24,
792
]
],
[
[
582,
24,
738
],
[
738,
63,... | [
[
[
"Reteplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Reteplase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile",
... | Reteplase may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Rivaroxaban
Reteplase may cause a moderate interaction that could exacerbate diseases when taken with Milnacipran and Milnacipran ... |
DB00674 | DB01268 | 1,516 | 1,151 | [
"DDInter802",
"DDInter1731"
] | Galantamine | Sunitinib | Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease. First characterized in the early 1950s, galantamine is a tertiary alkaloid that was extracted from botanical sour... | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Moderate | 1 | [
[
[
1516,
24,
1151
]
],
[
[
1516,
7,
10365
],
[
10365,
45,
1151
]
],
[
[
1516,
6,
8374
],
[
8374,
45,
1151
]
],
[
[
1516,
18,
15501
],
[
1... | [
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
]
],
[
[
"Galantamine",
"{u} (Compound) upregulates {v} (Gene)",
"STK10"
],
[
"STK10",
"{u} (Gene) is bound by {v} (Compou... | Galantamine (Compound) upregulates STK10 (Gene) and STK10 (Gene) is bound by Sunitinib (Compound)
Galantamine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sunitinib (Compound)
Galantamine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Sunitinib (Compound)
Galantamine (Compo... |
DB00445 | DB14568 | 322 | 982 | [
"DDInter655",
"DDInter1000"
] | Epirubicin | Ivosidenib | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
322,
25,
982
]
],
[
[
322,
23,
112
],
[
112,
23,
982
]
],
[
[
322,
63,
168
],
[
168,
23,
982
]
],
[
[
322,
25,
976
],
[
976,
24,... | [
[
[
"Epirubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Epirubicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronida... | Epirubicin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bort... |
DB00241 | DB01070 | 288 | 1,098 | [
"DDInter257",
"DDInter558"
] | Butalbital | Dihydrotachysterol | Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervou... | A vitamin D that can be regarded as a reduction product of vitamin D2. | Moderate | 1 | [
[
[
288,
24,
1098
]
],
[
[
288,
63,
386
],
[
386,
25,
1098
]
],
[
[
288,
24,
1041
],
[
1041,
25,
1098
]
],
[
[
288,
1,
536
],
[
536,
... | [
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dihydrotachysterol"
]
],
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cholecalciferol"
... | Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Cholecalciferol and Cholecalciferol may lead to a major life threatening interaction when taken with Dihydrotachysterol
Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Paricalcitol and P... |
DB00495 | DB12332 | 139 | 1,619 | [
"DDInter1961",
"DDInter1626"
] | Zidovudine | Rucaparib | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
139,
24,
1619
]
],
[
[
139,
24,
259
],
[
259,
24,
1619
]
],
[
[
139,
63,
58
],
[
58,
24,
1619
]
],
[
[
139,
64,
1101
],
[
1101,
... | [
[
[
"Zidovudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Zidovudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
],
[
... | Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib
Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacep... |
DB12035 | DB12332 | 943 | 1,619 | [
"DDInter1641",
"DDInter1626"
] | Sarecycline | Rucaparib | Sarecycline is a semi-synthetic derivative of tetracycline that was initially discovered by Paratek Pharmaceuticals from Boston, MA but then licensed to Warner Chilcott of Rockaway, NJ in July of 2007. After completing various phase-II and phase-III trials demonstrating its effectiveness in treating moderate to severe ... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
943,
24,
1619
]
],
[
[
943,
62,
1135
],
[
1135,
23,
1619
]
],
[
[
943,
63,
309
],
[
309,
24,
1619
]
],
[
[
943,
24,
159
],
[
159,
... | [
[
[
"Sarecycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Sarecycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Sarecycline may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Sarecycline may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixabepilon... |
DB00810 | DB01278 | 456 | 1,021 | [
"DDInter211",
"DDInter1506"
] | Biperiden | Pramlintide | A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine. | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Moderate | 1 | [
[
[
456,
24,
1021
]
],
[
[
456,
63,
1507
],
[
1507,
24,
1021
]
],
[
[
456,
1,
1105
],
[
1105,
24,
1021
]
],
[
[
456,
24,
543
],
[
543,
... | [
[
[
"Biperiden",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pramlintide"
]
],
[
[
"Biperiden",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dicyclomine"
],
[
... | Biperiden may cause a moderate interaction that could exacerbate diseases when taken with Dicyclomine and Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Pramlintide
Biperiden (Compound) resembles Trihexyphenidyl (Compound) and Trihexyphenidyl may cause a moderate interaction... |
DB00047 | DB09038 | 176 | 1,450 | [
"DDInter932",
"DDInter636"
] | Insulin glargine | Empagliflozin | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
176,
24,
1450
]
],
[
[
176,
23,
1103
],
[
1103,
23,
1450
]
],
[
[
176,
24,
461
],
[
461,
24,
1450
]
],
[
[
176,
24,
659
],
[
659,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Insulin glargine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
... | Insulin glargine may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Empagliflozin
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Timolol an... |
DB00814 | DB13074 | 1,171 | 877 | [
"DDInter1143",
"DDInter1110"
] | Meloxicam | Macimorelin | Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is ... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Moderate | 1 | [
[
[
1171,
24,
877
]
],
[
[
1171,
24,
1479
],
[
1479,
24,
877
]
],
[
[
1171,
1,
1027
],
[
1027,
24,
877
]
],
[
[
1171,
63,
251
],
[
251,
... | [
[
[
"Meloxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Macimorelin"
]
],
[
[
"Meloxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
],... | Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Macimorelin
Meloxicam (Compound) resembles Piroxicam (Compound) and Piroxicam may cause a moderate inter... |
DB00662 | DB01320 | 717 | 651 | [
"DDInter1873",
"DDInter783"
] | Trimethobenzamide | Fosphenytoin | Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against e... | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Moderate | 1 | [
[
[
717,
24,
651
]
],
[
[
717,
63,
362
],
[
362,
1,
651
]
],
[
[
717,
21,
28691
],
[
28691,
60,
651
]
],
[
[
717,
24,
1264
],
[
1264,
... | [
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
... | Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Compound)
Trimethobenzamide (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Fosphenytoin (Compound)
Trimethobenzamide may caus... |
DB00282 | DB00795 | 641 | 50 | [
"DDInter1383",
"DDInter1725"
] | Pamidronic acid | Sulfasalazine | Pamidronic acid is a second generation, nitrogen containing bisphosphonate similar to [neridronic acid] and [alendronic acid]. Pamidronic acid was first described in the literature in 1977. The second generation bisphosphonates are less common as third generation bisphosphonates, such as [ibandronic acid], [zoledronic ... | Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down i... | Moderate | 1 | [
[
[
641,
24,
50
]
],
[
[
641,
24,
712
],
[
712,
1,
50
]
],
[
[
641,
24,
1481
],
[
1481,
24,
50
]
],
[
[
641,
24,
1272
],
[
1272,
63,... | [
[
[
"Pamidronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfasalazine"
]
],
[
[
"Pamidronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olsalazine"
... | Pamidronic acid may cause a moderate interaction that could exacerbate diseases when taken with Olsalazine and Olsalazine (Compound) resembles Sulfasalazine (Compound)
Pamidronic acid may cause a moderate interaction that could exacerbate diseases when taken with Polymyxin B and Polymyxin B may cause a moderate interac... |
DB00182 | DB09241 | 80 | 1,629 | [
"DDInter84",
"DDInter1186"
] | Amphetamine | Methylene blue | Amphetamine, a compound discovered over 100 years ago, is one of the more restricted controlled drugs. It was previously used for a large variety of conditions and this changed until this point where its use is highly restricted. Amphetamine, with the chemical formula alpha-methylphenethylamine, was discovered in 1910 ... | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Major | 2 | [
[
[
80,
25,
1629
]
],
[
[
80,
24,
1148
],
[
1148,
24,
1629
]
],
[
[
80,
40,
73
],
[
73,
25,
1629
]
],
[
[
80,
24,
1445
],
[
1445,
25... | [
[
[
"Amphetamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylene blue"
]
],
[
[
"Amphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
[
"Is... | Amphetamine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Amphetamine (Compound) resembles Phentermine (Compound) and Phentermine may lead to a major life threat... |
DB00333 | DB01246 | 576 | 820 | [
"DDInter1166",
"DDInter45"
] | Methadone | Alimemazine | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | A phenothiazine derivative that is used as an antipruritic. | Major | 2 | [
[
[
576,
36,
820
]
],
[
[
576,
1,
358
],
[
358,
24,
820
]
],
[
[
576,
24,
104
],
[
104,
40,
820
]
],
[
[
576,
36,
401
],
[
401,
24,
... | [
[
[
"Methadone",
"{u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v}",
"Alimemazine"
]
],
[
[
"Methadone",
"{u} (Compound) resembles {v} (Compound)",
"Orphenadrine"
],
[
"Orphenadrine"... | Methadone (Compound) resembles Alimemazine (Compound) and
Methadone (Compound) resembles Orphenadrine (Compound) and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Methadone may cause a moderate interaction that could exacerbate diseases when taken with Methdila... |
DB00218 | DB00675 | 1,176 | 888 | [
"DDInter1247",
"DDInter1744"
] | Moxifloxacin | Tamoxifen | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Major | 2 | [
[
[
1176,
25,
888
]
],
[
[
1176,
24,
543
],
[
543,
63,
888
]
],
[
[
1176,
21,
29152
],
[
29152,
60,
888
]
],
[
[
1176,
23,
112
],
[
112,
... | [
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tamoxifen"
]
],
[
[
"Moxifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loperamide"
],
[
"Loperam... | Moxifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen
Moxifloxacin (Compound) causes Thirst (Side Effect) and Thirst (Side Effect) is caused by Tamoxifen (Compound)
... |
DB00620 | DB00861 | 175 | 914 | [
"DDInter1855",
"DDInter551"
] | Triamcinolone | Diflunisal | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | Moderate | 1 | [
[
[
175,
24,
914
]
],
[
[
175,
6,
7720
],
[
7720,
45,
914
]
],
[
[
175,
5,
11577
],
[
11577,
49,
914
]
],
[
[
175,
18,
1918
],
[
1918,
... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diflunisal"
]
],
[
[
"Triamcinolone",
"{u} (Compound) binds {v} (Gene)",
"PTGS2"
],
[
"PTGS2",
"{u} (Gene) is bound by {v} (Compoun... | Triamcinolone (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Diflunisal (Compound)
Triamcinolone (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is palliated by Diflunisal (Compound)
Triamcinolone (Compound) downregulates PCNA (Gene) and PCNA (Gene) is downregulated by Di... |
DB00250 | DB06186 | 10 | 1,439 | [
"DDInter475",
"DDInter969"
] | Dapsone | Ipilimumab | A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of m... | Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes.[A35065,A35080,L12126] Ipilimumab was developed by Bristol-Myers Squibb and Medarex. Ipilimumab was granted FDA approva... | Moderate | 1 | [
[
[
10,
24,
1439
]
],
[
[
10,
24,
1060
],
[
1060,
63,
1439
]
],
[
[
10,
63,
268
],
[
268,
24,
1439
]
],
[
[
10,
24,
671
],
[
671,
24... | [
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ipilimumab"
]
],
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enfortumab vedotin"
],
[
... | Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Enfortumab vedotin and Enfortumab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Ipilimumab
Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Peginterfer... |
DB00278 | DB00580 | 291 | 311 | [
"DDInter117",
"DDInter1910"
] | Argatroban | Valdecoxib | Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant sh... | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Moderate | 1 | [
[
[
291,
24,
311
]
],
[
[
291,
64,
366
],
[
366,
24,
311
]
],
[
[
291,
25,
500
],
[
500,
63,
311
]
],
[
[
291,
24,
1512
],
[
1512,
6... | [
[
[
"Argatroban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valdecoxib"
]
],
[
[
"Argatroban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eptifibatide"
],
[
"Eptifiba... | Argatroban may lead to a major life threatening interaction when taken with Eptifibatide and Eptifibatide may cause a moderate interaction that could exacerbate diseases when taken with Valdecoxib
Argatroban may lead to a major life threatening interaction when taken with Enoxaparin and Enoxaparin may cause a moderate ... |
DB00582 | DB01216 | 1,622 | 284 | [
"DDInter1946",
"DDInter736"
] | Voriconazole | Finasteride | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Finasteride is a synthetic 4-azasteroid compound and specific inhibitor of steroid Type II 5α-reductase, which is an intracellular enzyme that converts the androgen testosterone into 5α-dihydrotestosterone (DHT). It works in a similar fashion as [dutasteride], which is another 5-alpha-reductase inhibitor, by exerting a... | Moderate | 1 | [
[
[
1622,
24,
284
]
],
[
[
1622,
6,
6799
],
[
6799,
45,
284
]
],
[
[
1622,
21,
29247
],
[
29247,
60,
284
]
],
[
[
1622,
24,
98
],
[
98,
... | [
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Finasteride"
]
],
[
[
"Voriconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A7"
],
[
"CYP3A7",
"{u} (Gene) is bound by {v} (Compou... | Voriconazole (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Finasteride (Compound)
Voriconazole (Compound) causes Pharyngitis (Side Effect) and Pharyngitis (Side Effect) is caused by Finasteride (Compound)
Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Somatre... |
DB00327 | DB01041 | 421 | 770 | [
"DDInter890",
"DDInter1789"
] | Hydromorphone | Thalidomide | Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of [morphine] that has been available clinically since 1920. Structurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 a... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
421,
24,
770
]
],
[
[
421,
6,
10522
],
[
10522,
45,
770
]
],
[
[
421,
21,
28789
],
[
28789,
60,
770
]
],
[
[
421,
24,
849
],
[
849,
... | [
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Hydromorphone",
"{u} (Compound) binds {v} (Gene)",
"PTGS1"
],
[
"PTGS1",
"{u} (Gene) is bound by {v} (Compou... | Hydromorphone (Compound) binds PTGS1 (Gene) and PTGS1 (Gene) is bound by Thalidomide (Compound)
Hydromorphone (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Thalidomide (Compound)
Hydromorphone may cause a moderate interaction that could exacerbate diseases wh... |
DB00206 | DB00668 | 1,245 | 874 | [
"DDInter1582",
"DDInter652"
] | Reserpine | Epinephrine | An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a rese... | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Moderate | 1 | [
[
[
1245,
24,
874
]
],
[
[
1245,
24,
1636
],
[
1636,
1,
874
]
],
[
[
1245,
24,
1148
],
[
1148,
63,
874
]
],
[
[
1245,
6,
10715
],
[
10715,... | [
[
[
"Reserpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
]
],
[
[
"Reserpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylephrine"
],
[
... | Reserpine may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine and Phenylephrine (Compound) resembles Epinephrine (Compound)
Reserpine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction t... |
DB00719 | DB00909 | 1,219 | 306 | [
"DDInter149",
"DDInter1971"
] | Azatadine | Zonisamide | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. This... | Major | 2 | [
[
[
1219,
25,
306
]
],
[
[
1219,
6,
8374
],
[
8374,
45,
306
]
],
[
[
1219,
24,
1609
],
[
1609,
63,
306
]
],
[
[
1219,
63,
717
],
[
717,
... | [
[
[
"Azatadine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zonisamide"
]
],
[
[
"Azatadine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Zonisamid... | Azatadine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Zonisamide (Compound)
Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine and Pentoxyverine may cause a moderate interaction that could exacerbate diseases when taken with Zonisamide
Azatadine may ... |
DB00108 | DB06674 | 1,066 | 908 | [
"DDInter1268",
"DDInter837"
] | Natalizumab | Golimumab | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Major | 2 | [
[
[
1066,
25,
908
]
],
[
[
1066,
23,
1193
],
[
1193,
62,
908
]
],
[
[
1066,
23,
1461
],
[
1461,
23,
908
]
],
[
[
1066,
64,
268
],
[
268,
... | [
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Golimumab"
]
],
[
[
"Natalizumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Zinc gl... | Natalizumab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Golimumab
Natalizumab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vita... |
DB01381 | DB09075 | 958 | 498 | [
"DDInter819",
"DDInter621"
] | Ginkgo biloba | Edoxaban | _Ginkgo biloba_ extract contains a group of terpene lactones (notably, ginkgolides and diterpenes) and ginkgo flavone glycosides (notably, ginkgetin, bilobetin, and sciadopitysin) that have antioxidant and vasoactive properties. Most of the studies that investigate the effect of _ginkgo biloba_ use the standardized ext... | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Moderate | 1 | [
[
[
958,
24,
498
]
],
[
[
958,
63,
222
],
[
222,
24,
498
]
],
[
[
958,
24,
129
],
[
129,
24,
498
]
],
[
[
958,
24,
913
],
[
913,
63,... | [
[
[
"Ginkgo biloba",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Edoxaban"
]
],
[
[
"Ginkgo biloba",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
... | Ginkgo biloba may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Edoxaban
Ginkgo biloba may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide an... |
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