drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00774 | DB01156 | 1,577 | 593 | [
"DDInter889",
"DDInter252"
] | Hydroflumethiazide | Bupropion | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822) | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Moderate | 1 | [
[
[
1577,
24,
593
]
],
[
[
1577,
7,
12648
],
[
12648,
46,
593
]
],
[
[
1577,
18,
6718
],
[
6718,
57,
593
]
],
[
[
1577,
21,
29164
],
[
291... | [
[
[
"Hydroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bupropion"
]
],
[
[
"Hydroflumethiazide",
"{u} (Compound) upregulates {v} (Gene)",
"GPER1"
],
[
"GPER1",
"{u} (Gene) is upregu... | Hydroflumethiazide (Compound) upregulates GPER1 (Gene) and GPER1 (Gene) is upregulated by Bupropion (Compound)
Hydroflumethiazide (Compound) downregulates USP22 (Gene) and USP22 (Gene) is downregulated by Bupropion (Compound)
Hydroflumethiazide (Compound) causes Photosensitivity (Side Effect) and Photosensitivity (Side... |
DB00563 | DB01285 | 663 | 708 | [
"DDInter1174",
"DDInter445"
] | Methotrexate | Corticotropin | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Moderate | 1 | [
[
[
663,
24,
708
]
],
[
[
663,
23,
126
],
[
126,
24,
708
]
],
[
[
663,
24,
123
],
[
123,
24,
708
]
],
[
[
663,
63,
1014
],
[
1014,
2... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
]
],
[
[
"Methotrexate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Warfarin"
],
[... | Methotrexate may cause a minor interaction that can limit clinical effects when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Exenatide and Exenat... |
DB11921 | DB13074 | 1,019 | 877 | [
"DDInter492",
"DDInter1110"
] | Deflazacort | Macimorelin | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Moderate | 1 | [
[
[
1019,
24,
877
]
],
[
[
1019,
63,
1020
],
[
1020,
24,
877
]
],
[
[
1019,
64,
651
],
[
651,
24,
877
]
],
[
[
1019,
24,
1654
],
[
1654,
... | [
[
[
"Deflazacort",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Macimorelin"
]
],
[
[
"Deflazacort",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clonidine"
],
[
... | Deflazacort may cause a moderate interaction that could exacerbate diseases when taken with Clonidine and Clonidine may cause a moderate interaction that could exacerbate diseases when taken with Macimorelin
Deflazacort may lead to a major life threatening interaction when taken with Fosphenytoin and Fosphenytoin may c... |
DB00877 | DB14723 | 629 | 159 | [
"DDInter1678",
"DDInter1026"
] | Sirolimus | Larotrectinib | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
629,
24,
159
]
],
[
[
629,
24,
222
],
[
222,
23,
159
]
],
[
[
629,
23,
907
],
[
907,
23,
159
]
],
[
[
629,
63,
1230
],
[
1230,
2... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Sirolimus may cause a minor interaction that can limit clinical effects when taken with Doravirine and Doravir... |
DB11581 | DB11793 | 1,456 | 738 | [
"DDInter1926",
"DDInter1297"
] | Venetoclax | Niraparib | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process,. Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small lym... | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
1456,
24,
738
]
],
[
[
1456,
24,
466
],
[
466,
63,
738
]
],
[
[
1456,
63,
1213
],
[
1213,
24,
738
]
],
[
[
1456,
64,
759
],
[
759,
... | [
[
[
"Venetoclax",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Venetoclax",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
... | Venetoclax may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Venetoclax may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasa... |
DB00056 | DB01155 | 816 | 872 | [
"DDInter814",
"DDInter813"
] | Gemtuzumab ozogamicin | Gemifloxacin | Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from fermentation of Micromonospora echinospora ssp. calichensis. Gemtuzumab ozogamicin has approximately 50% of the antibody loaded with 4-6 moles calicheami... | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Minor | 0 | [
[
[
816,
23,
872
]
],
[
[
816,
23,
739
],
[
739,
1,
872
]
],
[
[
816,
23,
945
],
[
945,
40,
872
]
],
[
[
816,
24,
869
],
[
869,
23,
... | [
[
[
"Gemtuzumab ozogamicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Gemifloxacin"
]
],
[
[
"Gemtuzumab ozogamicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lomeflo... | Gemtuzumab ozogamicin may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gemifloxacin (Compound)
Gemtuzumab ozogamicin may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin and Sparfloxacin (Compound) rese... |
DB00661 | DB01218 | 122 | 1,493 | [
"DDInter1928",
"DDInter852"
] | Verapamil | Halofantrine | Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Major | 2 | [
[
[
122,
25,
1493
]
],
[
[
122,
6,
3486
],
[
3486,
45,
1493
]
],
[
[
122,
21,
28763
],
[
28763,
60,
1493
]
],
[
[
122,
24,
770
],
[
770,
... | [
[
[
"Verapamil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Halofantrine"
]
],
[
[
"Verapamil",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",
"Halofan... | Verapamil (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Halofantrine (Compound)
Verapamil (Compound) causes Chest pain (Side Effect) and Chest pain (Side Effect) is caused by Halofantrine (Compound)
Verapamil may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and ... |
DB00674 | DB06616 | 1,516 | 594 | [
"DDInter802",
"DDInter224"
] | Galantamine | Bosutinib | Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease. First characterized in the early 1950s, galantamine is a tertiary alkaloid that was extracted from botanical sour... | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Moderate | 1 | [
[
[
1516,
24,
594
]
],
[
[
1516,
6,
8374
],
[
8374,
45,
594
]
],
[
[
1516,
7,
10365
],
[
10365,
45,
594
]
],
[
[
1516,
7,
11074
],
[
11074... | [
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
]
],
[
[
"Galantamine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Galantamine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bosutinib (Compound)
Galantamine (Compound) upregulates STK10 (Gene) and STK10 (Gene) is bound by Bosutinib (Compound)
Galantamine (Compound) upregulates HERC6 (Gene) and HERC6 (Gene) is upregulated by Bosutinib (Compound)
Galantamine (Compound) d... |
DB00436 | DB00959 | 323 | 1,486 | [
"DDInter179",
"DDInter1191"
] | Bendroflumethiazide | Methylprednisolone | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810) | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Moderate | 1 | [
[
[
323,
24,
1486
]
],
[
[
323,
24,
175
],
[
175,
40,
1486
]
],
[
[
323,
24,
167
],
[
167,
1,
1486
]
],
[
[
323,
21,
28714
],
[
28714,
... | [
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"T... | Bendroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Bendroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Co... |
DB08882 | DB11718 | 1,281 | 927 | [
"DDInter1070",
"DDInter640"
] | Linagliptin | Encorafenib | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes. Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin w... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
1281,
24,
927
]
],
[
[
1281,
63,
216
],
[
216,
24,
927
]
],
[
[
1281,
24,
659
],
[
659,
24,
927
]
],
[
[
1281,
24,
1399
],
[
1399,
... | [
[
[
"Linagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Linagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpromazine"
],
... | Linagliptin may cause a moderate interaction that could exacerbate diseases when taken with Chlorpromazine and Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Linagliptin may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol... |
DB00675 | DB09080 | 888 | 144 | [
"DDInter1744",
"DDInter1331"
] | Tamoxifen | Olodaterol | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
888,
24,
144
]
],
[
[
888,
23,
1247
],
[
1247,
23,
144
]
],
[
[
888,
24,
956
],
[
956,
24,
144
]
],
[
[
888,
25,
371
],
[
371,
2... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Tamoxifen",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
... | Tamoxifen may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Olodaterol
Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Norfloxacin and... |
DB00176 | DB06754 | 529 | 707 | [
"DDInter770",
"DDInter471"
] | Fluvoxamine | Danaparoid | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans . The active constituents are heparan, dermatan and , and they are isolated from the porcine intestinal mucosa [FDA Label]. Danaparoid possesses a potent antithrombic activity t... | Moderate | 1 | [
[
[
529,
24,
707
]
],
[
[
529,
25,
121
],
[
121,
24,
707
]
],
[
[
529,
24,
235
],
[
235,
64,
707
]
],
[
[
529,
63,
1172
],
[
1172,
2... | [
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Danaparoid"
]
],
[
[
"Fluvoxamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fenfluramine"
],
[
"Fenflu... | Fluvoxamine may lead to a major life threatening interaction when taken with Fenfluramine and Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Danaparoid
Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Desirudin and Desirudin may le... |
DB04932 | DB10344 | 1,564 | 992 | [
"DDInter491",
"DDInter818"
] | Defibrotide | Ginger | Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Da... | Ginger allergenic extract is used in allergenic testing. | Moderate | 1 | [
[
[
1564,
24,
992
]
],
[
[
1564,
64,
1578
],
[
1578,
24,
992
]
],
[
[
1564,
25,
1421
],
[
1421,
63,
992
]
],
[
[
1564,
25,
802
],
[
802,
... | [
[
[
"Defibrotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginger"
]
],
[
[
"Defibrotide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lepirudin"
],
[
"Lepirudin",
... | Defibrotide may lead to a major life threatening interaction when taken with Lepirudin and Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Ginger
Defibrotide may lead to a major life threatening interaction when taken with Betrixaban and Betrixaban may cause a moderate interact... |
DB00108 | DB00163 | 1,066 | 1,461 | [
"DDInter1268",
"DDInter1943"
] | Natalizumab | Vitamin E | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Minor | 0 | [
[
[
1066,
23,
1461
]
],
[
[
1066,
25,
76
],
[
76,
62,
1461
]
],
[
[
1066,
64,
581
],
[
581,
23,
1461
]
],
[
[
1066,
25,
967
],
[
967,
... | [
[
[
"Natalizumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
]
],
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mogamulizumab"
],
[
"Mogamuli... | Natalizumab may lead to a major life threatening interaction when taken with Mogamulizumab and Mogamulizumab may cause a minor interaction that can limit clinical effects when taken with Vitamin E
Natalizumab may lead to a major life threatening interaction when taken with Infliximab and Infliximab may cause a minor in... |
DB00005 | DB14811 | 1,057 | 385 | [
"DDInter687",
"DDInter979"
] | Etanercept | Isatuximab | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Isatuximab (formerly SAR650984) is a humanized, IgG1-derived monoclonal antibody (mAb) produced from a Chinese hamster ovary (CHO) cell line.[L12099,A191799] Structurally, isatuximab is comprised of two identical immunoglobulin kappa light chains and two identical immunoglobulin gamma heavy chains. It is a cytolytic an... | Major | 2 | [
[
[
1057,
25,
385
]
],
[
[
1057,
25,
1362
],
[
1362,
24,
385
]
],
[
[
1057,
24,
599
],
[
599,
24,
385
]
],
[
[
1057,
25,
908
],
[
908,
... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Isatuximab"
]
],
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Olaparib"
],
[
"Olaparib",
"{u} may c... | Etanercept may lead to a major life threatening interaction when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Isatuximab
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab and Alemtuzumab may cause a ... |
DB00401 | DB08868 | 84 | 1,011 | [
"DDInter1298",
"DDInter737"
] | Nisoldipine | Fingolimod | Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contractio... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Moderate | 1 | [
[
[
84,
24,
1011
]
],
[
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84,
6,
8374
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[
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45,
1011
]
],
[
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84,
21,
29271
],
[
29271,
60,
1011
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],
[
[
84,
23,
578
],
[
578,
... | [
[
[
"Nisoldipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fingolimod"
]
],
[
[
"Nisoldipine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Nisoldipine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fingolimod (Compound)
Nisoldipine (Compound) causes Migraine (Side Effect) and Migraine (Side Effect) is caused by Fingolimod (Compound)
Nisoldipine may cause a minor interaction that can limit clinical effects when taken with Ticagrelor and Ticag... |
DB00331 | DB08870 | 1,645 | 850 | [
"DDInter1164",
"DDInter228"
] | Metformin | Brentuximab vedotin | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
1645,
24,
850
]
],
[
[
1645,
24,
1338
],
[
1338,
24,
850
]
],
[
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1645,
24,
1033
],
[
1033,
63,
850
]
],
[
[
1645,
63,
245
],
[
245,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meclofenamic acid"
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Meclofenamic acid and Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Metformin may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00530 | DB00951 | 1,195 | 1,072 | [
"DDInter667",
"DDInter986"
] | Erlotinib | Isoniazid | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Moderate | 1 | [
[
[
1195,
24,
1072
]
],
[
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1195,
6,
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],
[
8374,
45,
1072
]
],
[
[
1195,
21,
28722
],
[
28722,
60,
1072
]
],
[
[
1195,
24,
115
],
[
11... | [
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoniazid"
]
],
[
[
"Erlotinib",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Erlotinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Isoniazid (Compound)
Erlotinib (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Isoniazid (Compound)
Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Aluminum hydroxide and Aluminu... |
DB09039 | DB14975 | 1,670 | 988 | [
"DDInter629",
"DDInter1949"
] | Eliglustat | Voxelotor | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Voxelotor is a novel hemoglobin S polymerization inhibitor for the treatment of sickle cell disease. This is a genetically inherited condition most prevalent in the Middle East, Africa, and certain parts of India. Sickle cell disease can lead to excruciating pain, stroke, infection, and various other complications aris... | Major | 2 | [
[
[
1670,
25,
988
]
],
[
[
1670,
63,
629
],
[
629,
24,
988
]
],
[
[
1670,
24,
971
],
[
971,
24,
988
]
],
[
[
1670,
64,
723
],
[
723,
... | [
[
[
"Eliglustat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Voxelotor"
]
],
[
[
"Eliglustat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
],
[
"Sirolimus",
... | Eliglustat may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Voxelotor
Eliglustat may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib and Gilteri... |
DB00208 | DB00586 | 1,018 | 1,512 | [
"DDInter1804",
"DDInter537"
] | Ticlopidine | Diclofenac | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Moderate | 1 | [
[
[
1018,
24,
1512
]
],
[
[
1018,
24,
1263
],
[
1263,
63,
1512
]
],
[
[
1018,
6,
8374
],
[
8374,
45,
1512
]
],
[
[
1018,
21,
28957
],
[
28... | [
[
[
"Ticlopidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenac"
]
],
[
[
"Ticlopidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bromfenac"
],
[
... | Ticlopidine may cause a moderate interaction that could exacerbate diseases when taken with Bromfenac and Bromfenac may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac
Ticlopidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Diclofenac (Compound)
Ticlopidine (Compo... |
DB00005 | DB12674 | 1,057 | 975 | [
"DDInter687",
"DDInter1105"
] | Etanercept | Lurbinectedin | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative of the marine-derived agent ecteinascidin ([trabectedin]), an anticancer agent fou... | Major | 2 | [
[
[
1057,
25,
975
]
],
[
[
1057,
25,
1488
],
[
1488,
24,
975
]
],
[
[
1057,
24,
522
],
[
522,
24,
975
]
],
[
[
1057,
25,
994
],
[
994,
... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lurbinectedin"
]
],
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fludarabine"
],
[
"Fludarabine",
"... | Etanercept may lead to a major life threatening interaction when taken with Fludarabine and Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Zafirlukast and Zafirlukast may... |
DB04951 | DB11963 | 187 | 1,045 | [
"DDInter1477",
"DDInter465"
] | Pirfenidone | Dacomitinib | Pirfenidone is a synthetic pyridone drug. It is an antifibrotic agent with anti-inflammatory and antioxidant properties that is used to treat idiopathic pulmonary fibrosis (IPF), which is a chronic, progressive form of interstitial pneumonia. While its mechanism of action is not yet fully understood, pirfenidone is pro... | Dacomitinib, designed as (2E)-N-16-4-(piperidin-1-yl) but-2-enamide, is an oral highly selective quinazalone part of the second-generation tyrosine kinase inhibitors which are characterized by the irreversible binding at the ATP domain of the epidermal growth factor receptor family kinase domains. Dacomitinib was devel... | Moderate | 1 | [
[
[
187,
24,
1045
]
],
[
[
187,
24,
384
],
[
384,
24,
1045
]
],
[
[
187,
63,
143
],
[
143,
24,
1045
]
],
[
[
187,
64,
529
],
[
529,
... | [
[
[
"Pirfenidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dacomitinib"
]
],
[
[
"Pirfenidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
[... | Pirfenidone may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Dacomitinib
Pirfenidone may cause a moderate interaction that could exacerbate diseases when taken with Mexiletine and Mex... |
DB01110 | DB06697 | 86 | 436 | [
"DDInter1209",
"DDInter121"
] | Miconazole | Artemether | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Artemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of <i>Plasmodium spp.</i> and may be used to treat infections caused by <i>P. falciparum</... | Moderate | 1 | [
[
[
86,
24,
436
]
],
[
[
86,
6,
12523
],
[
12523,
45,
436
]
],
[
[
86,
24,
1678
],
[
1678,
63,
436
]
],
[
[
86,
63,
1336
],
[
1336,
... | [
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Artemether"
]
],
[
[
"Miconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",... | Miconazole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Artemether (Compound)
Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Lesinurad and Lesinurad may cause a moderate interaction that could exacerbate diseases when taken with Artemether
Miconazole may cause... |
DB00197 | DB00619 | 1,324 | 1,419 | [
"DDInter1881",
"DDInter909"
] | Troglitazone | Imatinib | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Moderate | 1 | [
[
[
1324,
24,
1419
]
],
[
[
1324,
23,
1459
],
[
1459,
62,
1419
]
],
[
[
1324,
24,
907
],
[
907,
62,
1419
]
],
[
[
1324,
23,
1101
],
[
1101... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
]
],
[
[
"Troglitazone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dolutegravir"
],
[
... | Troglitazone may cause a minor interaction that can limit clinical effects when taken with Dolutegravir and Dolutegravir may cause a minor interaction that can limit clinical effects when taken with Imatinib
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Doravirine and Dora... |
DB01319 | DB08816 | 34 | 578 | [
"DDInter777",
"DDInter1802"
] | Fosamprenavir | Ticagrelor | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
34,
24,
578
]
],
[
[
34,
6,
8374
],
[
8374,
45,
578
]
],
[
[
34,
21,
28646
],
[
28646,
60,
578
]
],
[
[
34,
25,
1135
],
[
1135,
... | [
[
[
"Fosamprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Fosamprenavir",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compo... | Fosamprenavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ticagrelor (Compound)
Fosamprenavir (Compound) causes Unspecified disorder of skin and subcutaneous tissue (Side Effect) and Unspecified disorder of skin and subcutaneous tissue (Side Effect) is caused by Ticagrelor (Compound)
Fosamprenavir may ... |
DB00365 | DB09020 | 839 | 28 | [
"DDInter842",
"DDInter212"
] | Grepafloxacin | Bisacodyl | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
839,
24,
28
]
],
[
[
839,
25,
823
],
[
823,
63,
28
]
],
[
[
839,
25,
870
],
[
870,
24,
28
]
],
[
[
839,
64,
702
],
[
702,
24,
... | [
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Triclabendazole"
],
[
"... | Grepafloxacin may lead to a major life threatening interaction when taken with Triclabendazole and Triclabendazole may cause a moderate interaction that could exacerbate diseases when taken with Bisacodyl
Grepafloxacin may lead to a major life threatening interaction when taken with Fludrocortisone and Fludrocortisone ... |
DB00445 | DB05273 | 322 | 507 | [
"DDInter655",
"DDInter1638"
] | Epirubicin | Samarium (153Sm) lexidronam | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.Samarium ... | Major | 2 | [
[
[
322,
25,
507
]
],
[
[
322,
24,
789
],
[
789,
24,
507
]
],
[
[
322,
24,
270
],
[
270,
63,
507
]
],
[
[
322,
63,
1101
],
[
1101,
2... | [
[
[
"Epirubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Samarium (153Sm) lexidronam"
]
],
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Foscarnet"
],
[
... | Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Foscarnet and Foscarnet may cause a moderate interaction that could exacerbate diseases when taken with Samarium (153Sm) lexidronam
Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Ocreli... |
DB08864 | DB12267 | 786 | 1,476 | [
"DDInter1595",
"DDInter233"
] | Rilpivirine | Brigatinib | Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients. It is a diarylpyrimidine derivative. The internal conformational flexibility of rilpivirine and the plasticity of it interacting binding site gives it a very high potenc... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
786,
24,
1476
]
],
[
[
786,
24,
951
],
[
951,
24,
1476
]
],
[
[
786,
63,
918
],
[
918,
24,
1476
]
],
[
[
786,
64,
379
],
[
379,
... | [
[
[
"Rilpivirine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Rilpivirine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
],
[... | Rilpivirine may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib and Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib
Rilpivirine may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and ... |
DB01073 | DB10315 | 1,488 | 1,137 | [
"DDInter745",
"DDInter1127"
] | Fludarabine | Measles virus vaccine live attenuated | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
1488,
25,
1137
]
],
[
[
1488,
64,
581
],
[
581,
25,
1137
]
],
[
[
1488,
24,
384
],
[
384,
25,
1137
]
],
[
[
1488,
63,
1184
],
[
1184,
... | [
[
[
"Fludarabine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Fludarabine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Infliximab"
],
[
... | Fludarabine may lead to a major life threatening interaction when taken with Infliximab and Infliximab may lead to a major life threatening interaction when taken with Measles virus vaccine live attenuated
Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelali... |
DB05239 | DB09280 | 866 | 1,604 | [
"DDInter425",
"DDInter1101"
] | Cobimetinib | Lumacaftor | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Major | 2 | [
[
[
866,
25,
1604
]
],
[
[
866,
63,
522
],
[
522,
24,
1604
]
],
[
[
866,
24,
1468
],
[
1468,
24,
1604
]
],
[
[
866,
64,
307
],
[
307,
... | [
[
[
"Cobimetinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lumacaftor"
]
],
[
[
"Cobimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zafirlukast"
],
[
"Zafirlu... | Cobimetinib may cause a moderate interaction that could exacerbate diseases when taken with Zafirlukast and Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Lumacaftor
Cobimetinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib and Pon... |
DB00712 | DB15035 | 1,274 | 503 | [
"DDInter764",
"DDInter1959"
] | Flurbiprofen (ophthalmic) | Zanubrutinib | Flurbiprofen can cause developmental toxicity and female reproductive toxicity according to state or federal government labeling requirements. | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Moderate | 1 | [
[
[
1274,
37,
503
]
],
[
[
1274,
24,
222
],
[
222,
24,
503
]
],
[
[
1274,
63,
121
],
[
121,
24,
503
]
],
[
[
1274,
62,
752
],
[
752,
... | [
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that... | Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib and Flurbiprofen may lead to a major life threatening interaction when taken with Zanubrutinib
Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramin... |
DB01211 | DB06626 | 609 | 263 | [
"DDInter393",
"DDInter147"
] | Clarithromycin | Axitinib | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | Major | 2 | [
[
[
609,
25,
263
]
],
[
[
609,
63,
1215
],
[
1215,
23,
263
]
],
[
[
609,
62,
660
],
[
660,
23,
263
]
],
[
[
609,
24,
101
],
[
101,
2... | [
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Axitinib"
]
],
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lansoprazole"
],
[
"La... | Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Lansoprazole and Lansoprazole may cause a minor interaction that can limit clinical effects when taken with Axitinib
Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Esomeprazole an... |
DB01087 | DB06699 | 1,520 | 774 | [
"DDInter1520",
"DDInter493"
] | Primaquine | Degarelix | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Moderate | 1 | [
[
[
1520,
24,
774
]
],
[
[
1520,
63,
521
],
[
521,
1,
774
]
],
[
[
1520,
21,
28722
],
[
28722,
60,
774
]
],
[
[
1520,
62,
112
],
[
112,
... | [
[
[
"Primaquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Degarelix"
]
],
[
[
"Primaquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Goserelin"
],
[
... | Primaquine may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin (Compound) resembles Degarelix (Compound)
Primaquine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Degarelix (Compound)
Primaquine may cause a minor interaction that can limi... |
DB11691 | DB11978 | 1,499 | 124 | [
"DDInter1258",
"DDInter822"
] | Naldemedine | Glasdegib | Naldemedine is an opioid receptor antagonist [FDA Label]. It is a modified form of to which a side chain has been added to increase molecular weight and polar surface area resulting in restricted transport across the blood brain barrier. Naldemedine was approved in 2017 in both the US and Japan for the treatment of Opi... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
1499,
24,
124
]
],
[
[
1499,
63,
1135
],
[
1135,
23,
124
]
],
[
[
1499,
63,
79
],
[
79,
24,
124
]
],
[
[
1499,
24,
1339
],
[
1339,
... | [
[
[
"Naldemedine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Naldemedine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
[
... | Naldemedine may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Naldemedine may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib ... |
DB01036 | DB12267 | 211 | 1,476 | [
"DDInter1832",
"DDInter233"
] | Tolterodine | Brigatinib | Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence. Tolterodine acts on M2 and M3 subtypes of muscarinic receptors. | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
211,
24,
1476
]
],
[
[
211,
63,
629
],
[
629,
24,
1476
]
],
[
[
211,
24,
918
],
[
918,
24,
1476
]
],
[
[
211,
62,
883
],
[
883,
... | [
[
[
"Tolterodine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Tolterodine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
],
[
... | Tolterodine may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib
Tolterodine may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bica... |
DB00916 | DB01118 | 112 | 33 | [
"DDInter1202",
"DDInter76"
] | Metronidazole | Amiodarone | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Moderate | 1 | [
[
[
112,
24,
33
]
],
[
[
112,
23,
540
],
[
540,
1,
33
]
],
[
[
112,
6,
3486
],
[
3486,
45,
33
]
],
[
[
112,
21,
28779
],
[
28779,
60... | [
[
[
"Metronidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiodarone"
]
],
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dronedarone"
],
... | Metronidazole may cause a minor interaction that can limit clinical effects when taken with Dronedarone and Dronedarone (Compound) resembles Amiodarone (Compound)
Metronidazole (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Amiodarone (Compound)
Metronidazole (Compound) causes Dry mouth (Side Effect) and ... |
DB05528 | DB12001 | 1,070 | 564 | [
"DDInter1228",
"DDInter7"
] | Mipomersen | Abemaciclib | Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. M... | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Major | 2 | [
[
[
1070,
25,
564
]
],
[
[
1070,
25,
868
],
[
868,
24,
564
]
],
[
[
1070,
64,
392
],
[
392,
24,
564
]
],
[
[
1070,
25,
159
],
[
159,
... | [
[
[
"Mipomersen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Abemaciclib"
]
],
[
[
"Mipomersen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
],
[
"Vemurafenib",
"{u... | Mipomersen may lead to a major life threatening interaction when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Mipomersen may lead to a major life threatening interaction when taken with Lapatinib and Lapatinib may cause a moderate int... |
DB00431 | DB01381 | 1,503 | 958 | [
"DDInter1072",
"DDInter819"
] | Lindane | Ginkgo biloba | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | _Ginkgo biloba_ extract contains a group of terpene lactones (notably, ginkgolides and diterpenes) and ginkgo flavone glycosides (notably, ginkgetin, bilobetin, and sciadopitysin) that have antioxidant and vasoactive properties. Most of the studies that investigate the effect of _ginkgo biloba_ use the standardized ext... | Moderate | 1 | [
[
[
1503,
24,
958
]
],
[
[
1503,
63,
1010
],
[
1010,
24,
958
]
],
[
[
1503,
24,
121
],
[
121,
24,
958
]
],
[
[
1503,
24,
129
],
[
129,
... | [
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginkgo biloba"
]
],
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mefloquine"
],
[
... | Lindane may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine and Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Ginkgo biloba
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine and Fenflur... |
DB01023 | DB01088 | 409 | 714 | [
"DDInter716",
"DDInter908"
] | Felodipine | Iloprost | Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte... | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Moderate | 1 | [
[
[
409,
24,
714
]
],
[
[
409,
63,
1479
],
[
1479,
24,
714
]
],
[
[
409,
24,
1450
],
[
1450,
63,
714
]
],
[
[
409,
24,
848
],
[
848,
... | [
[
[
"Felodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
]
],
[
[
"Felodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
],
... | Felodipine may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Iloprost
Felodipine may cause a moderate interaction that could exacerbate diseases when taken with Emp... |
DB00486 | DB11632 | 1,614 | 580 | [
"DDInter1253",
"DDInter1343"
] | Nabilone | Opicapone | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Opicapone is a potent, reversible, and peripherally-acting third-generation inhibitor of catechol-o-methyltransferase (COMT), an enzyme involved in the breakdown of various catecholamines including dopamine.[A36938, A203048] Many patients with Parkinson’s disease treated with levodopa plus a dopa decarboxylase (DDC) in... | Moderate | 1 | [
[
[
1614,
24,
580
]
],
[
[
1614,
24,
104
],
[
104,
24,
580
]
],
[
[
1614,
63,
999
],
[
999,
24,
580
]
],
[
[
1614,
40,
530
],
[
530,
... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opicapone"
]
],
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
[
... | Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Opicapone
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine and T... |
DB00877 | DB06688 | 629 | 1,430 | [
"DDInter1678",
"DDInter1677"
] | Sirolimus | Sipuleucel-T | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Moderate | 1 | [
[
[
629,
24,
1430
]
],
[
[
629,
63,
175
],
[
175,
24,
1430
]
],
[
[
629,
25,
676
],
[
676,
63,
1430
]
],
[
[
629,
24,
1531
],
[
1531,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],
[... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T
Sirolimus may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib ... |
DB00945 | DB01138 | 1,479 | 804 | [
"DDInter20",
"DDInter1726"
] | Acetylsalicylic acid | Sulfinpyrazone | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties. | Moderate | 1 | [
[
[
1479,
24,
804
]
],
[
[
1479,
63,
998
],
[
998,
1,
804
]
],
[
[
1479,
6,
3486
],
[
3486,
45,
804
]
],
[
[
1479,
63,
1144
],
[
1144,
... | [
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfinpyrazone"
]
],
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phe... | Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutazone and Phenylbutazone (Compound) resembles Sulfinpyrazone (Compound)
Acetylsalicylic acid (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Sulfinpyrazone (Compound)
Acetylsalicylic acid may cause... |
DB00526 | DB00556 | 1,555 | 1,262 | [
"DDInter1355",
"DDInter1429"
] | Oxaliplatin | Perflutren | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultras... | Moderate | 1 | [
[
[
1555,
24,
1262
]
],
[
[
1555,
24,
679
],
[
679,
1,
1262
]
],
[
[
1555,
24,
112
],
[
112,
62,
1262
]
],
[
[
1555,
24,
355
],
[
355,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perflutren"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sevoflurane"
],
[... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Sevoflurane and Sevoflurane (Compound) resembles Perflutren (Compound)
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction tha... |
DB09263 | DB14491 | 1,436 | 428 | [
"DDInter1399",
"DDInter725"
] | Patiromer | Ferrous fumarate | Patiromer is a powder for suspension in water for oral administration, approved in the U.S. as Veltassa in October, 2015. Patiromer is supplied as patiromer sorbitex calcium which consists of the active moiety, patiromer, a non-absorbed potassium-binding polymer, and a calcium-sorbitol counterion. Each gram of patirome... | Used in treatment of iron deficiency anemia. | Moderate | 1 | [
[
[
1436,
24,
428
]
],
[
[
1436,
24,
1193
],
[
1193,
23,
428
]
],
[
[
1436,
63,
379
],
[
379,
24,
428
]
],
[
[
1436,
64,
1384
],
[
1384,
... | [
[
[
"Patiromer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous fumarate"
]
],
[
[
"Patiromer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc gluconate"
],
... | Patiromer may cause a moderate interaction that could exacerbate diseases when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Ferrous fumarate
Patiromer may cause a moderate interaction that could exacerbate diseases when taken with Rabeprazole... |
DB00818 | DB12015 | 898 | 1,033 | [
"DDInter1538",
"DDInter53"
] | Propofol | Alpelisib | Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associate... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
898,
24,
1033
]
],
[
[
898,
63,
322
],
[
322,
24,
1033
]
],
[
[
898,
24,
1342
],
[
1342,
24,
1033
]
],
[
[
898,
24,
982
],
[
982,
... | [
[
[
"Propofol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Propofol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
],
[
"... | Propofol may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Propofol may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin and Romidepsin ... |
DB00795 | DB09473 | 50 | 884 | [
"DDInter1725",
"DDInter918"
] | Sulfasalazine | Indium In-111 oxyquinoline | Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down i... | Indium In 111 oxyquinoline (oxine) is a diagnostic radiopharmaceutical intended for radiolabeling of autologous leukocytes. It is composed of a 3:1 saturated complex of In-111 isotope and oxyquinoline. Indium-111 decays by isomeric transition and electron capture to cadmium-111, emitting a gamma ray that can be detecte... | Moderate | 1 | [
[
[
50,
24,
884
]
],
[
[
50,
24,
1448
],
[
1448,
24,
884
]
],
[
[
50,
63,
1441
],
[
1441,
24,
884
]
],
[
[
50,
24,
1448
],
[
1448,
6... | [
[
[
"Sulfasalazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indium In-111 oxyquinoline"
]
],
[
[
"Sulfasalazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Strep... | Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Streptomycin and Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with Indium In-111 oxyquinoline
Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken ... |
DB01041 | DB04575 | 770 | 35 | [
"DDInter1789",
"DDInter1555"
] | Thalidomide | Quinestrol | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | The 3-cyclopentyl ether of ethinyl estradiol. | Major | 2 | [
[
[
770,
25,
35
]
],
[
[
770,
25,
890
],
[
890,
1,
35
]
],
[
[
770,
64,
559
],
[
559,
1,
35
]
],
[
[
770,
25,
177
],
[
177,
40,
... | [
[
[
"Thalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Quinestrol"
]
],
[
[
"Thalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mestranol"
],
[
"Mestranol",
"{u} (... | Thalidomide may lead to a major life threatening interaction when taken with Mestranol and Mestranol (Compound) resembles Quinestrol (Compound)
Thalidomide may lead to a major life threatening interaction when taken with Estrone and Estrone (Compound) resembles Quinestrol (Compound)
Thalidomide may lead to a major life... |
DB00662 | DB01069 | 717 | 401 | [
"DDInter1873",
"DDInter1533"
] | Trimethobenzamide | Promethazine | Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against e... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
717,
24,
401
]
],
[
[
717,
24,
146
],
[
146,
24,
401
]
],
[
[
717,
24,
1264
],
[
1264,
63,
401
]
],
[
[
717,
63,
1236
],
[
1236,
... | [
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propiomazin... | Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Propiomazine and Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with D... |
DB00440 | DB01132 | 1,548 | 1,130 | [
"DDInter1874",
"DDInter1472"
] | Trimethoprim | Pioglitazone | Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it prevents the synthesis of bacterial DNA and ultimately continued bacterial survival. Trimethoprim is often used in comb... | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Moderate | 1 | [
[
[
1548,
24,
1130
]
],
[
[
1548,
6,
6017
],
[
6017,
45,
1130
]
],
[
[
1548,
21,
28778
],
[
28778,
60,
1130
]
],
[
[
1548,
24,
1604
],
[
1... | [
[
[
"Trimethoprim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitazone"
]
],
[
[
"Trimethoprim",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compo... | Trimethoprim (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Pioglitazone (Compound)
Trimethoprim (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Pioglitazone (Compound)
Trimethoprim may cause a moderate interaction that could exacerbate diseases when ta... |
DB00372 | DB01591 | 999 | 667 | [
"DDInter1793",
"DDInter1696"
] | Thiethylperazine | Solifenacin | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004. | Moderate | 1 | [
[
[
999,
24,
667
]
],
[
[
999,
24,
1123
],
[
1123,
24,
667
]
],
[
[
999,
24,
407
],
[
407,
63,
667
]
],
[
[
999,
63,
352
],
[
352,
2... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Solifenacin"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propantheline"... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Propantheline and Propantheline may cause a moderate interaction that could exacerbate diseases when taken with Solifenacin
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Op... |
DB00196 | DB01110 | 600 | 86 | [
"DDInter743",
"DDInter1209"
] | Fluconazole | Miconazole | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Moderate | 1 | [
[
[
600,
24,
86
]
],
[
[
600,
6,
10215
],
[
10215,
45,
86
]
],
[
[
600,
54,
19182
],
[
19182,
15,
86
]
],
[
[
600,
21,
29122
],
[
29122,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miconazole"
]
],
[
[
"Fluconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compoun... | Fluconazole (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Miconazole (Compound)
Fluconazole (Compound) is included by Azoles (Pharmacologic Class) and Azoles (Pharmacologic Class) includes Miconazole (Compound)
Fluconazole (Compound) causes Mediastinal disorder (Side Effect) and Mediastinal disorder (S... |
DB00009 | DB00758 | 1,271 | 1,347 | [
"DDInter56",
"DDInter413"
] | Alteplase | Clopidogrel | Alteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent. It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots. In the absence of fibrin, the alteplase-mediated conversion of plasminogen is limited, thanks to the high affinity between alteplas... | Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recen... | Moderate | 1 | [
[
[
1271,
24,
1347
]
],
[
[
1271,
24,
1018
],
[
1018,
25,
1347
]
],
[
[
1271,
23,
539
],
[
539,
62,
1347
]
],
[
[
1271,
24,
958
],
[
958,
... | [
[
[
"Alteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clopidogrel"
]
],
[
[
"Alteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticlopidine"
],
[
... | Alteplase may cause a moderate interaction that could exacerbate diseases when taken with Ticlopidine and Ticlopidine may lead to a major life threatening interaction when taken with Clopidogrel
Alteplase may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a min... |
DB00673 | DB06595 | 723 | 1,491 | [
"DDInter112",
"DDInter1214"
] | Aprepitant | Midostaurin | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
723,
24,
1491
]
],
[
[
723,
25,
1135
],
[
1135,
62,
1491
]
],
[
[
723,
24,
761
],
[
761,
24,
1491
]
],
[
[
723,
63,
289
],
[
289,
... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Aprepitant",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol"... | Aprepitant may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Midostaurin
Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin and Saxagliptin may cause a... |
DB00795 | DB12615 | 50 | 1,381 | [
"DDInter1725",
"DDInter1482"
] | Sulfasalazine | Plazomicin | Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down i... | Developed by Achaogen biopharmaceuticals, plazomicin is a next-generation aminoglycoside synthetically derived from . The structure of plazomicin was established via appending hydroxylaminobutyric acid to at position 1 and 2-hydroxyethyl group at position 6' . It was designed to evade all clinically relevant aminoglyco... | Moderate | 1 | [
[
[
50,
24,
1381
]
],
[
[
50,
24,
416
],
[
416,
24,
1381
]
],
[
[
50,
40,
712
],
[
712,
24,
1381
]
],
[
[
50,
63,
91
],
[
91,
24,
... | [
[
[
"Sulfasalazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Plazomicin"
]
],
[
[
"Sulfasalazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Kanamycin"
],
... | Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Kanamycin and Kanamycin may cause a moderate interaction that could exacerbate diseases when taken with Plazomicin
Sulfasalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that c... |
DB00791 | DB10989 | 132 | 496 | [
"DDInter1902",
"DDInter858"
] | Uracil mustard | Hepatitis A Vaccine | Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage. | Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure. Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infectio... | Moderate | 1 | [
[
[
132,
24,
496
]
],
[
[
132,
24,
4
],
[
4,
24,
496
]
],
[
[
132,
24,
738
],
[
738,
63,
496
]
],
[
[
132,
25,
976
],
[
976,
24,
... | [
[
[
"Uracil mustard",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
]
],
[
[
"Uracil mustard",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxin... | Uracil mustard may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine
Uracil mustard may cause a moderate interaction that could exacerbate... |
DB01030 | DB09330 | 869 | 985 | [
"DDInter1835",
"DDInter1352"
] | Topotecan | Osimertinib | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Moderate | 1 | [
[
[
869,
24,
985
]
],
[
[
869,
63,
168
],
[
168,
23,
985
]
],
[
[
869,
63,
134
],
[
134,
24,
985
]
],
[
[
869,
62,
1684
],
[
1684,
2... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osimertinib"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelb... |
DB01232 | DB09073 | 1,327 | 951 | [
"DDInter1640",
"DDInter1379"
] | Saquinavir | Palbociclib | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Major | 2 | [
[
[
1327,
25,
951
]
],
[
[
1327,
25,
1476
],
[
1476,
63,
951
]
],
[
[
1327,
24,
1033
],
[
1033,
63,
951
]
],
[
[
1327,
64,
467
],
[
467,
... | [
[
[
"Saquinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Palbociclib"
]
],
[
[
"Saquinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brigatinib"
],
[
"Brigatinib",
"{u} ... | Saquinavir may lead to a major life threatening interaction when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib
Saquinavir may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and Alpelisib may cause a... |
DB00321 | DB08868 | 21 | 1,011 | [
"DDInter78",
"DDInter737"
] | Amitriptyline | Fingolimod | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
21,
25,
1011
]
],
[
[
21,
10,
11594
],
[
11594,
44,
1011
]
],
[
[
21,
6,
12523
],
[
12523,
45,
1011
]
],
[
[
21,
21,
28859
],
[
28859,... | [
[
[
"Amitriptyline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Amitriptyline",
"{u} (Compound) palliates {v} (Disease)",
"multiple sclerosis"
],
[
"multiple sclerosis",
"{u} (Disease) is ... | Amitriptyline (Compound) palliates multiple sclerosis (Disease) and multiple sclerosis (Disease) is treated by Fingolimod (Compound)
Amitriptyline (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Fingolimod (Compound)
Amitriptyline (Compound) causes Atrioventricular block (Side Effect) and Atrioventricular ... |
DB00398 | DB00420 | 79 | 508 | [
"DDInter1702",
"DDInter1532"
] | Sorafenib | Promazine | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | Moderate | 1 | [
[
[
79,
24,
508
]
],
[
[
79,
24,
1264
],
[
1264,
63,
508
]
],
[
[
79,
24,
1630
],
[
1630,
1,
508
]
],
[
[
79,
24,
1236
],
[
1236,
40... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promazine"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
"D... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promazine
Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Perphenazine and Perphenazine ... |
DB00448 | DB01112 | 1,215 | 665 | [
"DDInter1022",
"DDInter335"
] | Lansoprazole | Cefuroxime | Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole. It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux ... | Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus. | Moderate | 1 | [
[
[
1215,
24,
665
]
],
[
[
1215,
24,
1462
],
[
1462,
1,
665
]
],
[
[
1215,
21,
28784
],
[
28784,
60,
665
]
],
[
[
1215,
24,
1448
],
[
1448... | [
[
[
"Lansoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefuroxime"
]
],
[
[
"Lansoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefditoren"
],
... | Lansoprazole may cause a moderate interaction that could exacerbate diseases when taken with Cefditoren and Cefditoren (Compound) resembles Cefuroxime (Compound)
Lansoprazole (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Cefuroxime (Compound)
Lansoprazole may cause a m... |
DB00661 | DB06691 | 122 | 849 | [
"DDInter1928",
"DDInter1155"
] | Verapamil | Mepyramine | Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
122,
24,
849
]
],
[
[
122,
6,
12523
],
[
12523,
45,
849
]
],
[
[
122,
24,
770
],
[
770,
24,
849
]
],
[
[
122,
63,
1648
],
[
1648,
... | [
[
[
"Verapamil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Verapamil",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
... | Verapamil (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Mepyramine (Compound)
Verapamil may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Verapamil may caus... |
DB00688 | DB09104 | 955 | 286 | [
"DDInter1251",
"DDInter1118"
] | Mycophenolate mofetil | Magnesium hydroxide | Mycophenolate mofetil, also known as MMF or CellCept, is a prodrug of mycophenolic acid, and classified as a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). This drug is an immunosuppressant combined with drugs such as [Cyclosporine] and corticosteroids to prevent organ rejection after hepatic, ren... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
955,
24,
286
]
],
[
[
955,
24,
1283
],
[
1283,
24,
286
]
],
[
[
955,
63,
1572
],
[
1572,
24,
286
]
],
[
[
955,
1,
1096
],
[
1096,
... | [
[
[
"Mycophenolate mofetil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Mycophenolate mofetil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Mycophenolate mofetil may cause a moderate interaction that could exacerbate diseases when taken with Magnesium oxide and Magnesium oxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide
Mycophenolate mofetil may cause a moderate interaction that could exacerbate disea... |
DB00220 | DB00877 | 798 | 629 | [
"DDInter1276",
"DDInter1678"
] | Nelfinavir | Sirolimus | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Major | 2 | [
[
[
798,
25,
629
]
],
[
[
798,
6,
4973
],
[
4973,
45,
629
]
],
[
[
798,
7,
7374
],
[
7374,
46,
629
]
],
[
[
798,
7,
8733
],
[
8733,
... | [
[
[
"Nelfinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sirolimus"
]
],
[
[
"Nelfinavir",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Sirolimus"... | Nelfinavir (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sirolimus (Compound)
Nelfinavir (Compound) upregulates NUCB2 (Gene) and NUCB2 (Gene) is upregulated by Sirolimus (Compound)
Nelfinavir (Compound) upregulates PHGDH (Gene) and PHGDH (Gene) is downregulated by Sirolimus (Compound)
Nelfinavir (Compound)... |
DB00641 | DB08871 | 467 | 36 | [
"DDInter1675",
"DDInter666"
] | Simvastatin | Eribulin | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
467,
24,
36
]
],
[
[
467,
18,
16974
],
[
16974,
45,
36
]
],
[
[
467,
25,
122
],
[
122,
23,
36
]
],
[
[
467,
74,
1463
],
[
1463,
... | [
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Simvastatin",
"{u} (Compound) downregulates {v} (Gene)",
"TUBB6"
],
[
"TUBB6",
"{u} (Gene) is bound by {v} (Compo... | Simvastatin (Compound) downregulates TUBB6 (Gene) and TUBB6 (Gene) is bound by Eribulin (Compound)
Simvastatin may lead to a major life threatening interaction when taken with Verapamil and Verapamil may cause a minor interaction that can limit clinical effects when taken with Eribulin
Simvastatin (Compound) resembles ... |
DB01032 | DB08875 | 824 | 1,618 | [
"DDInter1522",
"DDInter262"
] | Probenecid | Cabozantinib | The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy. | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Moderate | 1 | [
[
[
824,
24,
1618
]
],
[
[
824,
1,
1401
],
[
1401,
25,
1618
]
],
[
[
824,
62,
1512
],
[
1512,
25,
1618
]
],
[
[
824,
23,
848
],
[
848,
... | [
[
[
"Probenecid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabozantinib"
]
],
[
[
"Probenecid",
"{u} (Compound) resembles {v} (Compound)",
"Procainamide"
],
[
"Procainamide",
"{u} may lead to a... | Probenecid (Compound) resembles Procainamide (Compound) and Procainamide may lead to a major life threatening interaction when taken with Cabozantinib
Probenecid may cause a minor interaction that can limit clinical effects when taken with Diclofenac and Diclofenac may lead to a major life threatening interaction when ... |
DB01362 | DB01403 | 497 | 9 | [
"DDInter960",
"DDInter1175"
] | Iohexol | Methotrimeprazine | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Major | 2 | [
[
[
497,
25,
9
]
],
[
[
497,
64,
1178
],
[
1178,
40,
9
]
],
[
[
497,
64,
1164
],
[
1164,
1,
9
]
],
[
[
497,
64,
401
],
[
401,
24,
... | [
[
[
"Iohexol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methotrimeprazine"
]
],
[
[
"Iohexol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trifluoperazine"
],
[
"Trifluoperazine",
... | Iohexol may lead to a major life threatening interaction when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Methotrimeprazine (Compound)
Iohexol may lead to a major life threatening interaction when taken with Trimipramine and Trimipramine (Compound) resembles Methotrimeprazine (Compound)
Iohexol ... |
DB00022 | DB00526 | 268 | 1,555 | [
"DDInter1408",
"DDInter1355"
] | Peginterferon alfa-2b | Oxaliplatin | Peginterferon alfa-2b is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Moderate | 1 | [
[
[
268,
24,
1555
]
],
[
[
268,
24,
810
],
[
810,
63,
1555
]
],
[
[
268,
24,
289
],
[
289,
24,
1555
]
],
[
[
268,
63,
1257
],
[
1257,
... | [
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin"
]
],
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stro... | Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89 and Strontium chloride Sr-89 may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin
Peginterferon alfa-2b may cause a moderate interaction that could exacer... |
DB11569 | DB11601 | 1,093 | 1,270 | [
"DDInter1003",
"DDInter1889"
] | Ixekizumab | Tuberculin purified protein derivative | Ixekizumab is a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody (mAb) against interleukin-17A (IL-17A) and prevents it from interacting with the IL-17A receptor. As IL-17A is a pro-inflammatory cytokine involved in inflammation and immune responses, blocking its effect is beneficial for use in inflamma... | Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The diagnostic test is commonly referred to as the Mantoux test which serves to minimize the risk of transmission of infection with *Mycoba... | Moderate | 1 | [
[
[
1093,
24,
1270
]
],
[
[
1093,
63,
1531
],
[
1531,
24,
1270
]
],
[
[
1093,
64,
1064
],
[
1064,
24,
1270
]
],
[
[
1093,
24,
1456
],
[
14... | [
[
[
"Ixekizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protein derivative"
]
],
[
[
"Ixekizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Ixekizumab may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab and Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative
Ixekizumab may lead to a major life threatening interaction when taken with Cladri... |
DB01035 | DB06791 | 1,401 | 1,446 | [
"DDInter1524",
"DDInter1021"
] | Procainamide | Lanreotide | A derivative of procaine with less CNS action. | Lanreotide is a drug employed in the management of acromegaly (a hormonal condition caused by excess growth hormone) in addition to symptoms caused by neuroendocrine tumors, especially carcinoid syndrome. This drug is a long-acting analog of the drug somatostatin, a growth hormone inhibitor. Lanreotide is manufactured ... | Moderate | 1 | [
[
[
1401,
24,
1446
]
],
[
[
1401,
25,
971
],
[
971,
63,
1446
]
],
[
[
1401,
74,
608
],
[
608,
24,
1446
]
],
[
[
1401,
63,
1645
],
[
1645,
... | [
[
[
"Procainamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lanreotide"
]
],
[
[
"Procainamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gilteritinib"
],
[
"Gilt... | Procainamide may lead to a major life threatening interaction when taken with Gilteritinib and Gilteritinib may cause a moderate interaction that could exacerbate diseases when taken with Lanreotide
Procainamide (Compound) resembles Lidocaine (Compound) and Procainamide may cause a moderate interaction that could exace... |
DB00641 | DB12825 | 467 | 1,375 | [
"DDInter1675",
"DDInter1032"
] | Simvastatin | Lefamulin | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Moderate | 1 | [
[
[
467,
24,
1375
]
],
[
[
467,
24,
112
],
[
112,
23,
1375
]
],
[
[
467,
24,
159
],
[
159,
63,
1375
]
],
[
[
467,
24,
309
],
[
309,
... | [
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
]
],
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lefamulin
Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib an... |
DB00317 | DB14723 | 883 | 159 | [
"DDInter810",
"DDInter1026"
] | Gefitinib | Larotrectinib | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
883,
24,
159
]
],
[
[
883,
23,
479
],
[
479,
23,
159
]
],
[
[
883,
24,
1375
],
[
1375,
24,
159
]
],
[
[
883,
23,
307
],
[
307,
2... | [
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Gefitinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Donepezil"
],
[
... | Gefitinib may cause a minor interaction that can limit clinical effects when taken with Donepezil and Donepezil may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin and Lefamulin ma... |
DB00620 | DB13139 | 175 | 1,032 | [
"DDInter1855",
"DDInter1063"
] | Triamcinolone | Levosalbutamol | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). [Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective ... | Minor | 0 | [
[
[
175,
23,
1032
]
],
[
[
175,
40,
218
],
[
218,
23,
1032
]
],
[
[
175,
1,
617
],
[
617,
23,
1032
]
],
[
[
175,
23,
659
],
[
659,
2... | [
[
[
"Triamcinolone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Levosalbutamol"
]
],
[
[
"Triamcinolone",
"{u} (Compound) resembles {v} (Compound)",
"Beclomethasone dipropionate"
],
[
"Beclomethasone dip... | Triamcinolone (Compound) resembles Beclomethasone dipropionate (Compound) and Beclomethasone dipropionate may cause a minor interaction that can limit clinical effects when taken with Levosalbutamol
Triamcinolone (Compound) resembles Budesonide (Compound) and Budesonide may cause a minor interaction that can limit clin... |
DB00290 | DB00552 | 329 | 1,238 | [
"DDInter219",
"DDInter1425"
] | Bleomycin | Pentostatin | A complex of related glycopeptide antibiotics from <i>Streptomyces verticillus</i> consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin. | A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | Moderate | 1 | [
[
[
329,
24,
1238
]
],
[
[
329,
5,
11555
],
[
11555,
44,
1238
]
],
[
[
329,
21,
28769
],
[
28769,
60,
1238
]
],
[
[
329,
23,
1467
],
[
146... | [
[
[
"Bleomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentostatin"
]
],
[
[
"Bleomycin",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease... | Bleomycin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Pentostatin (Compound)
Bleomycin (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Pentostatin (Compound)
Bleomycin may cause a minor interaction that can limit clinical... |
DB00046 | DB00717 | 1,179 | 1,197 | [
"DDInter940",
"DDInter1312"
] | Insulin lispro | Norethisterone | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins. It is further classified as a second-generation progestin, along with [levonorgestrel] and its derivatives, and is the active form of several other progestins including [no... | Moderate | 1 | [
[
[
1179,
24,
1197
]
],
[
[
1179,
24,
155
],
[
155,
1,
1197
]
],
[
[
1179,
24,
1687
],
[
1687,
40,
1197
]
],
[
[
1179,
24,
1130
],
[
1130,... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norethisterone"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxymesterone... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Fluoxymesterone and Fluoxymesterone (Compound) resembles Norethisterone (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Stanozolol and Stanozolol (Compound) resembles ... |
DB01589 | DB09293 | 481 | 116 | [
"DDInter1552",
"DDInter954"
] | Quazepam | Iodide I-131 | Quazepam is a trifluoroethyl benzodiazepine derivative. It was first approved in the US in 1985 and is used as a hypnotic for the treatment of insomnia. It appears to be unique amongst other benzodiazepine derivatives in its relatively high affinity for sleep-promoting α1 subunit-containing GABA<sub>A</sub> receptors a... | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
481,
24,
116
]
],
[
[
481,
63,
701
],
[
701,
24,
116
]
],
[
[
481,
24,
516
],
[
516,
24,
116
]
],
[
[
481,
40,
1418
],
[
1418,
2... | [
[
[
"Quazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Quazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
[
... | Quazepam may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Quazepam may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine and Levo... |
DB00285 | DB00852 | 1,100 | 1,445 | [
"DDInter1927",
"DDInter1545"
] | Venlafaxine | Pseudoephedrine | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseud... | Moderate | 1 | [
[
[
1100,
24,
1445
]
],
[
[
1100,
64,
73
],
[
73,
24,
1445
]
],
[
[
1100,
24,
22
],
[
22,
40,
1445
]
],
[
[
1100,
6,
7390
],
[
7390,
... | [
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pseudoephedrine"
]
],
[
[
"Venlafaxine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phentermine"
],
[
"Ph... | Venlafaxine may lead to a major life threatening interaction when taken with Phentermine and Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine
Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine and Ephedrine (Co... |
DB00222 | DB00451 | 245 | 542 | [
"DDInter825",
"DDInter1064"
] | Glimepiride | Levothyroxine | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Moderate | 1 | [
[
[
245,
24,
542
]
],
[
[
245,
24,
624
],
[
624,
1,
542
]
],
[
[
245,
21,
29222
],
[
29222,
60,
542
]
],
[
[
245,
24,
752
],
[
752,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levothyroxine"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liotrix"
],
[
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Liotrix and Liotrix (Compound) resembles Levothyroxine (Compound)
Glimepiride (Compound) causes Hypoglycaemia (Side Effect) and Hypoglycaemia (Side Effect) is caused by Levothyroxine (Compound)
Glimepiride may cause a moderate i... |
DB00727 | DB00747 | 685 | 1,442 | [
"DDInter1304",
"DDInter1647"
] | Nitroglycerin | Scopolamine | Nitroglycerin, also known as glyceryl trinitrate, is an organic nitrate and a vasodilating agent that was first discovered in 1847. Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure ex... | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | Minor | 0 | [
[
[
685,
23,
1442
]
],
[
[
685,
62,
19
],
[
19,
24,
1442
]
],
[
[
685,
21,
28766
],
[
28766,
60,
1442
]
],
[
[
685,
24,
1264
],
[
1264,
... | [
[
[
"Nitroglycerin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Scopolamine"
]
],
[
[
"Nitroglycerin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyoscyamine"
],
... | Nitroglycerin may cause a minor interaction that can limit clinical effects when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Scopolamine
Nitroglycerin (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Scopola... |
DB00331 | DB09263 | 1,645 | 1,436 | [
"DDInter1164",
"DDInter1399"
] | Metformin | Patiromer | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Patiromer is a powder for suspension in water for oral administration, approved in the U.S. as Veltassa in October, 2015. Patiromer is supplied as patiromer sorbitex calcium which consists of the active moiety, patiromer, a non-absorbed potassium-binding polymer, and a calcium-sorbitol counterion. Each gram of patirome... | Moderate | 1 | [
[
[
1645,
24,
1436
]
],
[
[
1645,
24,
708
],
[
708,
24,
1436
]
],
[
[
1645,
24,
1019
],
[
1019,
63,
1436
]
],
[
[
1645,
63,
1152
],
[
1152... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Patiromer"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
],
[
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin and Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Patiromer
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort and De... |
DB01064 | DB11124 | 1,148 | 209 | [
"DDInter987",
"DDInter1560"
] | Isoprenaline | Racepinephrine | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Racepinephrine is a racemic mixture consisting of d- and l- enantiomers. Epinephrine is a non-selective α- and β-adrenergic receptor agonist. It is a bronchodilator used in the temporary relief of mild symptoms of intermittent asthma including wheezing, tightness of chest and shortness of breath. It is an active ingred... | Moderate | 1 | [
[
[
1148,
24,
209
]
],
[
[
1148,
23,
1042
],
[
1042,
23,
209
]
],
[
[
1148,
62,
1573
],
[
1573,
23,
209
]
],
[
[
1148,
63,
688
],
[
688,
... | [
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Racepinephrine"
]
],
[
[
"Isoprenaline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Tetracosactide"
]... | Isoprenaline may cause a minor interaction that can limit clinical effects when taken with Tetracosactide and Tetracosactide may cause a minor interaction that can limit clinical effects when taken with Racepinephrine
Isoprenaline may cause a minor interaction that can limit clinical effects when taken with Prednisone ... |
DB00741 | DB09098 | 167 | 98 | [
"DDInter885",
"DDInter1700"
] | Hydrocortisone | Somatrem | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
167,
24,
98
]
],
[
[
167,
24,
336
],
[
336,
24,
98
]
],
[
[
167,
24,
159
],
[
159,
63,
98
]
],
[
[
167,
1,
1573
],
[
1573,
24,
... | [
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nifedipine"
],
... | Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Nifedipine and Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Somatrem
Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib a... |
DB01087 | DB01246 | 1,520 | 820 | [
"DDInter1520",
"DDInter45"
] | Primaquine | Alimemazine | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
1520,
24,
820
]
],
[
[
1520,
63,
401
],
[
401,
24,
820
]
],
[
[
1520,
63,
675
],
[
675,
25,
820
]
],
[
[
1520,
63,
508
],
[
508,
... | [
[
[
"Primaquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Primaquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[... | Primaquine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Primaquine may cause a moderate interaction that could exacerbate diseases when taken with Dextropropoxyphe... |
DB00108 | DB01030 | 1,066 | 869 | [
"DDInter1268",
"DDInter1835"
] | Natalizumab | Topotecan | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Major | 2 | [
[
[
1066,
25,
869
]
],
[
[
1066,
25,
613
],
[
613,
24,
869
]
],
[
[
1066,
25,
310
],
[
310,
63,
869
]
],
[
[
1066,
24,
1270
],
[
1270,
... | [
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Topotecan"
]
],
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Irinotecan"
],
[
"Irinotecan",
"{u} ... | Natalizumab may lead to a major life threatening interaction when taken with Irinotecan and Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Topotecan
Natalizumab may lead to a major life threatening interaction when taken with Cabazitaxel and Cabazitaxel may cause a moderate i... |
DB05351 | DB11963 | 101 | 1,045 | [
"DDInter519",
"DDInter465"
] | Dexlansoprazole | Dacomitinib | Dexlansoprazole is a new-generation proton pump inhibitor (PPI) used for the management of symptoms associated with gastroesophageal reflux disease (GERD) and erosive esophagitis. Dexlansoprazole is the R-enantiomer of, which is composed of a racemic mixture of the R- and S-enantiomers. Compared to the older generation... | Dacomitinib, designed as (2E)-N-16-4-(piperidin-1-yl) but-2-enamide, is an oral highly selective quinazalone part of the second-generation tyrosine kinase inhibitors which are characterized by the irreversible binding at the ATP domain of the epidermal growth factor receptor family kinase domains. Dacomitinib was devel... | Major | 2 | [
[
[
101,
25,
1045
]
],
[
[
101,
63,
80
],
[
80,
24,
1045
]
],
[
[
101,
62,
109
],
[
109,
24,
1045
]
],
[
[
101,
63,
80
],
[
80,
25,
... | [
[
[
"Dexlansoprazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dacomitinib"
]
],
[
[
"Dexlansoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amphetamine"
],
[
... | Dexlansoprazole may cause a moderate interaction that could exacerbate diseases when taken with Amphetamine and Amphetamine may cause a moderate interaction that could exacerbate diseases when taken with Dacomitinib
Dexlansoprazole may cause a minor interaction that can limit clinical effects when taken with Duloxetine... |
DB00333 | DB01166 | 576 | 477 | [
"DDInter1166",
"DDInter379"
] | Methadone | Cilostazol | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Major | 2 | [
[
[
576,
25,
477
]
],
[
[
576,
6,
8374
],
[
8374,
45,
477
]
],
[
[
576,
21,
28892
],
[
28892,
60,
477
]
],
[
[
576,
23,
112
],
[
112,
... | [
[
[
"Methadone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cilostazol"
]
],
[
[
"Methadone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Cilostazo... | Methadone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cilostazol (Compound)
Methadone (Compound) causes Cardiac arrest (Side Effect) and Cardiac arrest (Side Effect) is caused by Cilostazol (Compound)
Methadone may cause a minor interaction that can limit clinical effects when taken with Metronidazole ... |
DB00397 | DB01579 | 1,466 | 341 | [
"DDInter1458",
"DDInter1439"
] | Phenylpropanolamine | Phendimetrazine | Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. | Phendimetrazine is a weight loss medication. Phendimetrazine is chemically related to amphetamines and is a Schedule III drug under the Convention on Psychotropic Substances and in the US since 1970. | Major | 2 | [
[
[
1466,
25,
341
]
],
[
[
1466,
1,
111
],
[
111,
1,
341
]
],
[
[
1466,
5,
11585
],
[
11585,
44,
341
]
],
[
[
1466,
6,
2437
],
[
2437,
... | [
[
[
"Phenylpropanolamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phendimetrazine"
]
],
[
[
"Phenylpropanolamine",
"{u} (Compound) resembles {v} (Compound)",
"Tranylcypromine"
],
[
"Tranylcypromine",
"{u} (... | Phenylpropanolamine (Compound) resembles Tranylcypromine (Compound) and Tranylcypromine (Compound) resembles Phendimetrazine (Compound)
Phenylpropanolamine (Compound) treats obesity (Disease) and obesity (Disease) is treated by Phendimetrazine (Compound)
Phenylpropanolamine (Compound) binds SLC6A3 (Gene) and SLC6A3 (Ge... |
DB10276 | DB11817 | 1,624 | 1,259 | [
"DDInter1623",
"DDInter165"
] | Rotavirus vaccine | Baricitinib | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Major | 2 | [
[
[
1624,
25,
1259
]
],
[
[
1624,
64,
384
],
[
384,
25,
1259
]
],
[
[
1624,
25,
1619
],
[
1619,
64,
1259
]
],
[
[
1624,
25,
351
],
[
351,
... | [
[
[
"Rotavirus vaccine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Baricitinib"
]
],
[
[
"Rotavirus vaccine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idelalisib"
],
[
"Idelalisib... | Rotavirus vaccine may lead to a major life threatening interaction when taken with Idelalisib and Idelalisib may lead to a major life threatening interaction when taken with Baricitinib
Rotavirus vaccine may lead to a major life threatening interaction when taken with Rucaparib and Rucaparib may lead to a major life th... |
DB00983 | DB14881 | 480 | 180 | [
"DDInter776",
"DDInter1329"
] | Formoterol | Oliceridine | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Moderate | 1 | [
[
[
480,
24,
180
]
],
[
[
480,
24,
401
],
[
401,
24,
180
]
],
[
[
480,
63,
618
],
[
618,
24,
180
]
],
[
[
480,
63,
702
],
[
702,
25,... | [
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oliceridine"
]
],
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[... | Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Oliceridine
Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Abarelix and Aba... |
DB00215 | DB05578 | 1,230 | 330 | [
"DDInter388",
"DDInter1566"
] | Citalopram | Ramucirumab | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Ramucirumab is a human monoclonal antibody (IgG1) against vascular endothelial growth factor receptor 2 (VEGFR2), a type II trans-membrane tyrosine kinase receptor expressed on endothelial cells. By binding to VEGFR2, ramucirumab prevents binding of its ligands (VEGF-A, VEGF-C, and VEGF-D), thereby preventing VEGF-stim... | Moderate | 1 | [
[
[
1230,
24,
330
]
],
[
[
1230,
23,
384
],
[
384,
63,
330
]
],
[
[
1230,
1,
318
],
[
318,
24,
330
]
],
[
[
1230,
25,
222
],
[
222,
... | [
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ramucirumab"
]
],
[
[
"Citalopram",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Idelalisib"
],
[
... | Citalopram may cause a minor interaction that can limit clinical effects when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Ramucirumab
Citalopram (Compound) resembles Escitalopram (Compound) and Es
Citalopram may lead to a major life threatening in... |
DB00809 | DB00981 | 526 | 1,528 | [
"DDInter1885",
"DDInter1463"
] | Tropicamide (ophthalmic) | Physostigmine (ophthalmic) | Tropicamide is a member of acetamides. | Physostigmine is a carbamate ester and an indole alkaloid. It has a role as a miotic, an EC 3.1.1.8 (cholinesterase) inhibitor and an antidote to curare poisoning. | Moderate | 1 | [
[
[
526,
24,
1528
]
],
[
[
526,
21,
28658
],
[
28658,
60,
1528
]
],
[
[
526,
1,
832
],
[
832,
24,
1528
]
],
[
[
526,
40,
1376
],
[
1376,
... | [
[
[
"Tropicamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Physostigmine"
]
],
[
[
"Tropicamide",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Effect) is c... | Tropicamide may cause a moderate interaction that could exacerbate diseases when taken with Physostigmine
Tropicamide (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Physostigmine (Compound)
Tropicamide (Compound) resembles Tripelennamine (Compound) and Tripelennamine may cause a modera... |
DB00612 | DB09340 | 1,121 | 1,013 | [
"DDInter216",
"DDInter1895"
] | Bisoprolol | Tyropanoic acid | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | Tyropanoic acid is a radiocontrast agent used in cholecystography, the X-ray diagnosis of gallstones under the trade names include Bilopaque, Lumopaque, Tyropaque, and Bilopac. The molecule contains three heavy iodine atoms which obstruct X-rays in the same way as the calcium in bones, which results in a visible image ... | Moderate | 1 | [
[
[
1121,
24,
1013
]
],
[
[
1121,
24,
777
],
[
777,
24,
1013
]
],
[
[
1121,
1,
819
],
[
819,
24,
1013
]
],
[
[
1121,
40,
726
],
[
726,
... | [
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tyropanoic acid"
]
],
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopromide"
],
... | Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Iopromide and Iopromide may cause a moderate interaction that could exacerbate diseases when taken with Tyropanoic acid
Bisoprolol (Compound) resembles Acebutolol (Compound) and Acebutolol may cause a moderate interaction that co... |
DB00682 | DB00863 | 126 | 1,194 | [
"DDInter1951",
"DDInter1568"
] | Warfarin | Ranitidine | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as [cimetidine] and [famotidine]. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.[A176759,L10818]... | Moderate | 1 | [
[
[
126,
24,
1194
]
],
[
[
126,
6,
8374
],
[
8374,
45,
1194
]
],
[
[
126,
25,
59
],
[
59,
23,
1194
]
],
[
[
126,
63,
798
],
[
798,
2... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ranitidine"
]
],
[
[
"Warfarin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Warfarin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ranitidine (Compound)
Warfarin may lead to a major life threatening interaction when taken with Etodolac and Etodolac may cause a minor interaction that can limit clinical effects when taken with Ranitidine
Warfarin may cause a moderate interaction t... |
DB00357 | DB06589 | 1,051 | 1,250 | [
"DDInter71",
"DDInter1400"
] | Aminoglutethimide | Pazopanib | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
1051,
24,
1250
]
],
[
[
1051,
6,
7950
],
[
7950,
45,
1250
]
],
[
[
1051,
18,
5795
],
[
5795,
46,
1250
]
],
[
[
1051,
21,
28658
],
[
28... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Aminoglutethimide",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v}... | Aminoglutethimide (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Pazopanib (Compound)
Aminoglutethimide (Compound) downregulates PSMB8 (Gene) and PSMB8 (Gene) is upregulated by Pazopanib (Compound)
Aminoglutethimide (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Pazopanib... |
DB00697 | DB00787 | 876 | 387 | [
"DDInter1821",
"DDInter25"
] | Tizanidine | Acyclovir | Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury. It may also be caused by musculoskeletal injury. Regardless of the cause, muscle spasticity can be an extremely painful and debili... | Acyclovir is a nucleotide analog antiviral used to treat herpes simplex, _Varicella zoster_, herpes zoster, herpes labialis, and acute herpetic keratitis[L7303,L7315,L7318,L7321,L7324,L7327]. Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young a... | Major | 2 | [
[
[
876,
25,
387
]
],
[
[
876,
18,
6718
],
[
6718,
57,
387
]
],
[
[
876,
21,
29118
],
[
29118,
60,
387
]
],
[
[
876,
63,
372
],
[
372,
... | [
[
[
"Tizanidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acyclovir"
]
],
[
[
"Tizanidine",
"{u} (Compound) downregulates {v} (Gene)",
"USP22"
],
[
"USP22",
"{u} (Gene) is downregulated by {v} (Compound)",
... | Tizanidine (Compound) downregulates USP22 (Gene) and USP22 (Gene) is downregulated by Acyclovir (Compound)
Tizanidine (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Acyclovir (Compound)
Tizanidine may cause a moderate interaction that could exacerbate diseases when taken with Clo... |
DB00207 | DB00641 | 1,570 | 467 | [
"DDInter157",
"DDInter1675"
] | Azithromycin | Simvastatin | Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It was initially approved by the FDA in 1991. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually tra... | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Moderate | 1 | [
[
[
1570,
24,
467
]
],
[
[
1570,
6,
8374
],
[
8374,
45,
467
]
],
[
[
1570,
7,
7638
],
[
7638,
46,
467
]
],
[
[
1570,
18,
9205
],
[
9205,
... | [
[
[
"Azithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Simvastatin"
]
],
[
[
"Azithromycin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compou... | Azithromycin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Simvastatin (Compound)
Azithromycin (Compound) upregulates DENND2D (Gene) and DENND2D (Gene) is upregulated by Simvastatin (Compound)
Azithromycin (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is downregulated by Simvastatin (Compound)
A... |
DB00420 | DB01124 | 508 | 1,411 | [
"DDInter1532",
"DDInter1828"
] | Promazine | Tolbutamide | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
508,
24,
1411
]
],
[
[
508,
24,
959
],
[
959,
40,
1411
]
],
[
[
508,
63,
245
],
[
245,
40,
1411
]
],
[
[
508,
6,
10215
],
[
10215,
... | [
[
[
"Promazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Promazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Promazine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Promazine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Tolbutamide (Compound)
... |
DB01148 | DB01278 | 1,128 | 1,021 | [
"DDInter738",
"DDInter1506"
] | Flavoxate | Pramlintide | A drug that has been used in various urinary syndromes and as an antispasmodic. Its therapeutic usefulness and its mechanism of action are not clear. It may have local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a muscarinic antagonist. [PubChem] | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Moderate | 1 | [
[
[
1128,
24,
1021
]
],
[
[
1128,
63,
1507
],
[
1507,
24,
1021
]
],
[
[
1128,
24,
820
],
[
820,
24,
1021
]
],
[
[
1128,
24,
1511
],
[
1511... | [
[
[
"Flavoxate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pramlintide"
]
],
[
[
"Flavoxate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dicyclomine"
],
[
... | Flavoxate may cause a moderate interaction that could exacerbate diseases when taken with Dicyclomine and Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Pramlintide
Flavoxate may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alim... |
DB00242 | DB06176 | 1,064 | 1,342 | [
"DDInter392",
"DDInter1616"
] | Cladribine | Romidepsin | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Major | 2 | [
[
[
1064,
25,
1342
]
],
[
[
1064,
24,
336
],
[
336,
24,
1342
]
],
[
[
1064,
25,
485
],
[
485,
24,
1342
]
],
[
[
1064,
25,
1491
],
[
1491,
... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Romidepsin"
]
],
[
[
"Cladribine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nifedipine"
],
[
"Nifedipine... | Cladribine may cause a moderate interaction that could exacerbate diseases when taken with Nifedipine and Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin
Cladribine may lead to a major life threatening interaction when taken with Pentamidine and Pentamidine may caus... |
DB00439 | DB08912 | 289 | 1,040 | [
"DDInter341",
"DDInter462"
] | Cerivastatin | Dabrafenib | On August 8, 2001 the U.S. Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew Baycol from the U.S. market, due to reports of fatal rhabdomyolysis, a severe adverse reaction from this cholesterol-lowering (lipid-lowering) product. It has also been withdrawn from the Cana... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
289,
24,
1040
]
],
[
[
289,
63,
168
],
[
168,
23,
1040
]
],
[
[
289,
24,
478
],
[
478,
24,
1040
]
],
[
[
289,
24,
466
],
[
466,
... | [
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
... | Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Dabrafenib
Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilot... |
DB00630 | DB01268 | 1,485 | 1,151 | [
"DDInter42",
"DDInter1731"
] | Alendronic acid | Sunitinib | Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label]. | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Moderate | 1 | [
[
[
1485,
24,
1151
]
],
[
[
1485,
6,
7960
],
[
7960,
46,
1151
]
],
[
[
1485,
21,
28868
],
[
28868,
60,
1151
]
],
[
[
1485,
24,
603
],
[
60... | [
[
[
"Alendronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
]
],
[
[
"Alendronic acid",
"{u} (Compound) binds {v} (Gene)",
"FDPS"
],
[
"FDPS",
"{u} (Gene) is upregulated by {v} (... | Alendronic acid (Compound) binds FDPS (Gene) and FDPS (Gene) is upregulated by Sunitinib (Compound)
Alendronic acid (Compound) causes Stomatitis (Side Effect) and Stomatitis (Side Effect) is caused by Sunitinib (Compound)
Alendronic acid may cause a moderate interaction that could exacerbate diseases when taken with Ma... |
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