drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00328 | DB00619 | 831 | 1,419 | [
"DDInter921",
"DDInter909"
] | Indomethacin | Imatinib | Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlor... | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Moderate | 1 | [
[
[
831,
24,
1419
]
],
[
[
831,
6,
4973
],
[
4973,
45,
1419
]
],
[
[
831,
21,
28762
],
[
28762,
60,
1419
]
],
[
[
831,
24,
222
],
[
222,
... | [
[
[
"Indomethacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
]
],
[
[
"Indomethacin",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",... | Indomethacin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Imatinib (Compound)
Indomethacin (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Imatinib (Compound)
Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibut... |
DB00207 | DB01259 | 1,570 | 392 | [
"DDInter157",
"DDInter1024"
] | Azithromycin | Lapatinib | Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It was initially approved by the FDA in 1991. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually tra... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
1570,
24,
392
]
],
[
[
1570,
6,
4973
],
[
4973,
45,
392
]
],
[
[
1570,
18,
5795
],
[
5795,
46,
392
]
],
[
[
1570,
21,
29429
],
[
29429... | [
[
[
"Azithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Azithromycin",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)"... | Azithromycin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lapatinib (Compound)
Azithromycin (Compound) downregulates PSMB8 (Gene) and PSMB8 (Gene) is upregulated by Lapatinib (Compound)
Azithromycin (Compound) causes Infestation NOS (Side Effect) and Infestation NOS (Side Effect) is caused by Lapatinib (C... |
DB04845 | DB10795 | 309 | 221 | [
"DDInter1001",
"DDInter1486"
] | Ixabepilone | Poliovirus type 1 antigen (formaldehyde inactivated) | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
309,
24,
221
]
],
[
[
309,
24,
36
],
[
36,
24,
221
]
],
[
[
309,
64,
581
],
[
581,
24,
221
]
],
[
[
309,
63,
599
],
[
599,
24,
... | [
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken w... | Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Eribulin and Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Ixabepilone may lead to a major life threatening interaction when taken w... |
DB00222 | DB00880 | 245 | 359 | [
"DDInter825",
"DDInter360"
] | Glimepiride | Chlorothiazide | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) | Moderate | 1 | [
[
[
245,
24,
359
]
],
[
[
245,
24,
1577
],
[
1577,
1,
359
]
],
[
[
245,
21,
28784
],
[
28784,
60,
359
]
],
[
[
245,
24,
126
],
[
126,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorothiazide"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroflumethiazide"
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Hydroflumethiazide and Hydroflumethiazide (Compound) resembles Chlorothiazide (Compound)
Glimepiride (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Chlorothiazide (Compound)
Glim... |
DB08827 | DB11691 | 990 | 1,499 | [
"DDInter1085",
"DDInter1258"
] | Lomitapide | Naldemedine | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Naldemedine is an opioid receptor antagonist [FDA Label]. It is a modified form of to which a side chain has been added to increase molecular weight and polar surface area resulting in restricted transport across the blood brain barrier. Naldemedine was approved in 2017 in both the US and Japan for the treatment of Opi... | Moderate | 1 | [
[
[
990,
24,
1499
]
],
[
[
990,
64,
723
],
[
723,
24,
1499
]
],
[
[
990,
24,
1670
],
[
1670,
24,
1499
]
],
[
[
990,
25,
1593
],
[
1593,
... | [
[
[
"Lomitapide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naldemedine"
]
],
[
[
"Lomitapide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Aprepitant"
],
[
"Aprepitan... | Lomitapide may lead to a major life threatening interaction when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Naldemedine
Lomitapide may cause a moderate interaction that could exacerbate diseases when taken with Eliglustat and Eliglustat may cause... |
DB00421 | DB01222 | 443 | 617 | [
"DDInter1707",
"DDInter246"
] | Spironolactone | Budesonide | Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were disco... | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Moderate | 1 | [
[
[
443,
24,
617
]
],
[
[
443,
24,
251
],
[
251,
1,
617
]
],
[
[
443,
1,
1581
],
[
1581,
1,
617
]
],
[
[
443,
6,
1899
],
[
1899,
45,... | [
[
[
"Spironolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Budesonide"
]
],
[
[
"Spironolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betamethasone"
... | Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone (Compound) resembles Budesonide (Compound)
Spironolactone (Compound) resembles Testolactone (Compound) and Testolactone (Compound) resembles Budesonide (Compound)
Spironolactone (Compound) bind... |
DB00470 | DB14723 | 530 | 159 | [
"DDInter601",
"DDInter1026"
] | Dronabinol | Larotrectinib | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
530,
24,
159
]
],
[
[
530,
24,
222
],
[
222,
23,
159
]
],
[
[
530,
63,
1230
],
[
1230,
23,
159
]
],
[
[
530,
24,
1375
],
[
1375,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Citalopram and Cit... |
DB01110 | DB12240 | 86 | 110 | [
"DDInter1209",
"DDInter1485"
] | Miconazole | Polatuzumab vedotin | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Polatuzumab vedotin is a CD79b-directed antibody-drug conjugate that delivers monomethyl auristatin E (MMAE), an anti-mitotic agent, to cancer cells. The drug consists of three components - a humanized immunoglobulin G1 (IgG1) monoclonal antibody specific for human CD79b (polatuzumab), MMAE, and protease-cleavable link... | Moderate | 1 | [
[
[
86,
24,
110
]
],
[
[
86,
24,
129
],
[
129,
23,
110
]
],
[
[
86,
63,
467
],
[
467,
24,
110
]
],
[
[
86,
24,
578
],
[
578,
24,
... | [
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polatuzumab vedotin"
]
],
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
... | Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Polatuzumab vedotin
Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Simvastati... |
DB00814 | DB08912 | 1,171 | 1,040 | [
"DDInter1143",
"DDInter462"
] | Meloxicam | Dabrafenib | Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is ... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
1171,
24,
1040
]
],
[
[
1171,
6,
3486
],
[
3486,
45,
1040
]
],
[
[
1171,
21,
28900
],
[
28900,
60,
1040
]
],
[
[
1171,
63,
870
],
[
87... | [
[
[
"Meloxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Meloxicam",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",
... | Meloxicam (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Dabrafenib (Compound)
Meloxicam (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Dabrafenib (Compound)
Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortis... |
DB00738 | DB08875 | 485 | 1,618 | [
"DDInter1420",
"DDInter262"
] | Pentamidine | Cabozantinib | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
485,
25,
1618
]
],
[
[
485,
23,
112
],
[
112,
23,
1618
]
],
[
[
485,
24,
1032
],
[
1032,
63,
1618
]
],
[
[
485,
24,
480
],
[
480,
... | [
[
[
"Pentamidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Pentamidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metro... | Pentamidine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Levosalbutamol ... |
DB01067 | DB06335 | 959 | 761 | [
"DDInter826",
"DDInter1646"
] | Glipizide | Saxagliptin | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
959,
24,
761
]
],
[
[
959,
6,
8374
],
[
8374,
45,
761
]
],
[
[
959,
21,
28722
],
[
28722,
60,
761
]
],
[
[
959,
62,
1103
],
[
1103,
... | [
[
[
"Glipizide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Glipizide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Glipizide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Saxagliptin (Compound)
Glipizide (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Saxagliptin (Compound)
Glipizide may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide ma... |
DB01142 | DB08822 | 1,264 | 911 | [
"DDInter593",
"DDInter156"
] | Doxepin | Azilsartan medoxomil | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Azilsartan medoxomil is a prodrug that is broken down to azilsartan, which belongs in the angiotensin-receptor blocking (ARB) drug class. It is a selective AT1 subtype angiotensin II receptor antagonist. Azilsartan medoxomil is a relatively recently-developed antihypertensive drug that was first approved by the FDA in ... | Moderate | 1 | [
[
[
1264,
24,
911
]
],
[
[
1264,
63,
217
],
[
217,
1,
911
]
],
[
[
1264,
21,
28880
],
[
28880,
60,
911
]
],
[
[
1264,
63,
999
],
[
999,
... | [
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azilsartan medoxomil"
]
],
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olmesartan"
],
... | Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Olmesartan and Olmesartan (Compound) resembles Azilsartan medoxomil (Compound)
Doxepin (Compound) causes Angiopathy (Side Effect) and Angiopathy (Side Effect) is caused by Azilsartan medoxomil (Compound)
Doxepin may cause a moderate... |
DB00471 | DB01015 | 201 | 1,247 | [
"DDInter1242",
"DDInter1724"
] | Montelukast | Sulfamethoxazole | Montelukast was first approved for clinical use by the US FDA in 1998 as Merck's brand name Singulair. The medication is a member of the leukotriene receptor antagonist (LTRA) category of drugs.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Although capable of demonstrating effectiveness, the use of such LTRAs like montel... | Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps i... | Moderate | 1 | [
[
[
201,
24,
1247
]
],
[
[
201,
63,
161
],
[
161,
1,
1247
]
],
[
[
201,
6,
3486
],
[
3486,
45,
1247
]
],
[
[
201,
21,
29293
],
[
29293,
... | [
[
[
"Montelukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfamethoxazole"
]
],
[
[
"Montelukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfadiazine"
]... | Montelukast may cause a moderate interaction that could exacerbate diseases when taken with Sulfadiazine and Sulfadiazine (Compound) resembles Sulfamethoxazole (Compound)
Montelukast (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Sulfamethoxazole (Compound)
Montelukast (Compound) causes Leukocytoclastic v... |
DB01105 | DB01367 | 222 | 1,163 | [
"DDInter1665",
"DDInter1572"
] | Sibutramine | Rasagiline | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases. | Major | 2 | [
[
[
222,
25,
1163
]
],
[
[
222,
21,
28714
],
[
28714,
60,
1163
]
],
[
[
222,
63,
590
],
[
590,
24,
1163
]
],
[
[
222,
64,
1466
],
[
1466,
... | [
[
[
"Sibutramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rasagiline"
]
],
[
[
"Sibutramine",
"{u} (Compound) causes {v} (Side Effect)",
"Asthenia"
],
[
"Asthenia",
"{u} (Side Effect) is caused by {v} (Comp... | Sibutramine (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Rasagiline (Compound)
Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with R... |
DB00888 | DB14711 | 1,001 | 779 | [
"DDInter1133",
"DDInter1680"
] | Mechlorethamine | Smallpox (Vaccinia) Vaccine, Live | A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. The FDA granted marketing approval f... | The New York City Board of Health strain of _Vaccinia_ is a viral strain used as a component of some smallpox vaccinations. ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this strain. | Major | 2 | [
[
[
1001,
25,
779
]
],
[
[
1001,
64,
1064
],
[
1064,
25,
779
]
],
[
[
1001,
25,
1377
],
[
1377,
25,
779
]
],
[
[
1001,
63,
147
],
[
147,
... | [
[
[
"Mechlorethamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Smallpox (Vaccinia) Vaccine, Live"
]
],
[
[
"Mechlorethamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[... | Mechlorethamine may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Smallpox (Vaccinia) Vaccine, Live
Mechlorethamine may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may l... |
DB11828 | DB11952 | 1,406 | 800 | [
"DDInter1281",
"DDInter612"
] | Neratinib | Duvelisib | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Major | 2 | [
[
[
1406,
25,
800
]
],
[
[
1406,
63,
663
],
[
663,
24,
800
]
],
[
[
1406,
64,
1419
],
[
1419,
24,
800
]
],
[
[
1406,
25,
1017
],
[
1017,
... | [
[
[
"Neratinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Duvelisib"
]
],
[
[
"Neratinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
],
[
"Methotrexat... | Neratinib may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib
Neratinib may lead to a major life threatening interaction when taken with Imatinib and Imatinib may cause a m... |
DB05273 | DB08895 | 507 | 976 | [
"DDInter1638",
"DDInter1825"
] | Samarium (153Sm) lexidronam | Tofacitinib | Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.Samarium ... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
507,
25,
976
]
],
[
[
507,
63,
563
],
[
563,
24,
976
]
],
[
[
507,
25,
652
],
[
652,
64,
976
]
],
[
[
507,
64,
1555
],
[
1555,
2... | [
[
[
"Samarium (153Sm) lexidronam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Samarium (153Sm) lexidronam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gancicl... | Samarium (153Sm) lexidronam may cause a moderate interaction that could exacerbate diseases when taken with Ganciclovir and Ganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib
Samarium (153Sm) lexidronam may lead to a major life threatening interaction when taken with... |
DB01156 | DB12095 | 593 | 179 | [
"DDInter252",
"DDInter1760"
] | Bupropion | Telotristat ethyl | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Telotristat ethyl is a prodrug of telotristat that was approved by the FDA in March 2017 as Xermelo. It was previously referred to as telotristat etiprate, the hippurate salt form; however, the FDA recommends the use of the name of the neutral form rather than that of the salt.[A252937, A252942] Currently, telotristat ... | Moderate | 1 | [
[
[
593,
24,
179
]
],
[
[
593,
24,
1593
],
[
1593,
24,
179
]
],
[
[
593,
64,
175
],
[
175,
24,
179
]
],
[
[
593,
25,
129
],
[
129,
2... | [
[
[
"Bupropion",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telotristat ethyl"
]
],
[
[
"Bupropion",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
],
... | Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Telotristat ethyl
Bupropion may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone... |
DB06448 | DB12130 | 171 | 1,017 | [
"DDInter1087",
"DDInter1094"
] | Lonafarnib | Lorlatinib | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Major | 2 | [
[
[
171,
25,
1017
]
],
[
[
171,
63,
608
],
[
608,
23,
1017
]
],
[
[
171,
64,
175
],
[
175,
24,
1017
]
],
[
[
171,
25,
976
],
[
976,
... | [
[
[
"Lonafarnib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lorlatinib"
]
],
[
[
"Lonafarnib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
"Lidocaine",... | Lonafarnib may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Lonafarnib may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone may caus... |
DB00254 | DB09481 | 964 | 460 | [
"DDInter598",
"DDInter1113"
] | Doxycycline | Magnesium carbonate | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Moderate | 1 | [
[
[
964,
24,
460
]
],
[
[
964,
24,
1252
],
[
1252,
23,
460
]
],
[
[
964,
40,
1620
],
[
1620,
24,
460
]
],
[
[
964,
24,
955
],
[
955,
... | [
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digoxin"
],
... | Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Doxycycline (Compound) resembles Tetracycline (Compound) and Tetracycline may cause a moderate interaction tha... |
DB00662 | DB05541 | 717 | 801 | [
"DDInter1873",
"DDInter239"
] | Trimethobenzamide | Brivaracetam | Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against e... | Brivaracetam is a racetam derivative of levetiracetam used in the treatment of partial-onset seizures. Brivaracetam binds SV2A with 20 times higher affinity than levetiracetam . It is available under the brand name Briviact made by UCB. Briviact received FDA approval on February 19, 2016 . | Moderate | 1 | [
[
[
717,
24,
801
]
],
[
[
717,
63,
475
],
[
475,
24,
801
]
],
[
[
717,
24,
100
],
[
100,
24,
801
]
],
[
[
717,
24,
407
],
[
407,
63,... | [
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brivaracetam"
]
],
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Morphine"
... | Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Brivaracetam
Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Brompheni... |
DB01018 | DB01142 | 1,364 | 1,264 | [
"DDInter847",
"DDInter593"
] | Guanfacine | Doxepin | Guanfacine, or BS 100-141,[A189838,A189841] is a selective alpha-A2 adrenergic receptor agonist initially indicated for the treatment of hypertension but is now indicated as an extended release tablet for the treatment of ADHD. Guanfacine was first described in the literature in 1974. Guanfacine was granted FDA approva... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
1364,
24,
1264
]
],
[
[
1364,
24,
401
],
[
401,
24,
1264
]
],
[
[
1364,
24,
649
],
[
649,
63,
1264
]
],
[
[
1364,
6,
6017
],
[
6017,
... | [
[
[
"Guanfacine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Guanfacine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
... | Guanfacine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Guanfacine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofe... |
DB00651 | DB09278 | 746 | 852 | [
"DDInter613",
"DDInter24"
] | Dyphylline | Activated charcoal | Dyphylline is a theophylline derivative with broncho- and vasodilator properties. It is typically used in the management of asthma, cardiac dyspnea, and bronchitis. | Activated charcoal, or activated carbon, is an amorphous form of carbon prepared from incomplete combustion of carbonaceous organic matter. It is activated by an oxidizing gas flow at high temperature passed over its surface to make a fine network of pores, producing a material with large surface area and high affinity... | Moderate | 1 | [
[
[
746,
24,
852
]
],
[
[
746,
40,
1031
],
[
1031,
24,
852
]
],
[
[
746,
64,
17
],
[
17,
24,
852
]
],
[
[
746,
40,
1031
],
[
1031,
2... | [
[
[
"Dyphylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Activated charcoal"
]
],
[
[
"Dyphylline",
"{u} (Compound) resembles {v} (Compound)",
"Theophylline"
],
[
"Theophylline",
"{u} may cau... | Dyphylline (Compound) resembles Theophylline (Compound) and Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Activated charcoal
Dyphylline may lead to a major life threatening interaction when taken with Sotalol and Sotalol may cause a moderate interaction that could exacerba... |
DB00312 | DB08865 | 1,023 | 1,593 | [
"DDInter1423",
"DDInter448"
] | Pentobarbital | Crizotinib | A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Dr... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Moderate | 1 | [
[
[
1023,
24,
1593
]
],
[
[
1023,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
1023,
18,
4729
],
[
4729,
57,
1593
]
],
[
[
1023,
21,
28771
],
[
28... | [
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
]
],
[
[
"Pentobarbital",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compo... | Pentobarbital (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Pentobarbital (Compound) downregulates EBNA1BP2 (Gene) and EBNA1BP2 (Gene) is downregulated by Crizotinib (Compound)
Pentobarbital (Compound) causes Respiratory failure (Side Effect) and Respiratory failure (Side Effect) is... |
DB00808 | DB00816 | 1,605 | 1,674 | [
"DDInter916",
"DDInter1346"
] | Indapamide | Orciprenaline | The most significant modifiable risk factor for cardiovascular disease and the most prominent contributor to all-cause mortality is hypertension. Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts an estimated 25% of adults globally. Treatment for hypertension should include a n... | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Moderate | 1 | [
[
[
1605,
24,
1674
]
],
[
[
1605,
21,
28921
],
[
28921,
60,
1674
]
],
[
[
1605,
63,
251
],
[
251,
23,
1674
]
],
[
[
1605,
24,
891
],
[
891... | [
[
[
"Indapamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orciprenaline"
]
],
[
[
"Indapamide",
"{u} (Compound) causes {v} (Side Effect)",
"Dizziness"
],
[
"Dizziness",
"{u} (Side Effect) is c... | Indapamide (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Orciprenaline (Compound)
Indapamide may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone may cause a minor interaction that can limit clinical effects when taken with ... |
DB00261 | DB14357 | 702 | 944 | [
"DDInter93",
"DDInter347"
] | Anagrelide | Chamomile | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Chamomile is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. | Minor | 0 | [
[
[
702,
23,
944
]
],
[
[
702,
25,
256
],
[
256,
23,
944
]
],
[
[
702,
64,
366
],
[
366,
23,
944
]
],
[
[
702,
24,
1061
],
[
1061,
2... | [
[
[
"Anagrelide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
]
],
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prasugrel"
],
[
"Prasugrel",
... | Anagrelide may lead to a major life threatening interaction when taken with Prasugrel and Prasugrel may cause a minor interaction that can limit clinical effects when taken with Chamomile
Anagrelide may lead to a major life threatening interaction when taken with Eptifibatide and Eptifibatide may cause a minor interact... |
DB01181 | DB04896 | 1,532 | 901 | [
"DDInter906",
"DDInter1220"
] | Ifosfamide | Milnacipran | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Milnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment of depression [F3928, F3934, A175786, A175951]. Furthermore, in 2009 the US FDA approved milnacipran for the a... | Moderate | 1 | [
[
[
1532,
24,
901
]
],
[
[
1532,
24,
41
],
[
41,
1,
901
]
],
[
[
1532,
63,
1349
],
[
1349,
40,
901
]
],
[
[
1532,
21,
28723
],
[
28723,
... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milnacipran"
]
],
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
],
... | Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran and Levomilnacipran (Compound) resembles Milnacipran (Compound)
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Meperidine and Meperidine (Compound) resembles Milnacipran... |
DB00363 | DB00851 | 695 | 611 | [
"DDInter419",
"DDInter463"
] | Clozapine | Dacarbazine | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | Major | 2 | [
[
[
695,
25,
611
]
],
[
[
695,
6,
7950
],
[
7950,
45,
611
]
],
[
[
695,
64,
141
],
[
141,
24,
611
]
],
[
[
695,
25,
850
],
[
850,
63... | [
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dacarbazine"
]
],
[
[
"Clozapine",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
"Dacarbaz... | Clozapine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Dacarbazine (Compound)
Clozapine may lead to a major life threatening interaction when taken with Floxuridine and Floxuridine may cause a moderate interaction that could exacerbate diseases when taken with Dacarbazine
Clozapine may lead to a major l... |
DB01030 | DB04908 | 869 | 1,671 | [
"DDInter1835",
"DDInter741"
] | Topotecan | Flibanserin | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder... | Moderate | 1 | [
[
[
869,
24,
1671
]
],
[
[
869,
63,
168
],
[
168,
23,
1671
]
],
[
[
869,
24,
741
],
[
741,
63,
1671
]
],
[
[
869,
63,
51
],
[
51,
24... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flibanserin"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Flibanserin
Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant and Rolapitan... |
DB00377 | DB14881 | 1,494 | 180 | [
"DDInter1382",
"DDInter1329"
] | Palonosetron | Oliceridine | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Major | 2 | [
[
[
1494,
25,
180
]
],
[
[
1494,
23,
112
],
[
112,
23,
180
]
],
[
[
1494,
24,
401
],
[
401,
24,
180
]
],
[
[
1494,
63,
618
],
[
618,
... | [
[
[
"Palonosetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Oliceridine"
]
],
[
[
"Palonosetron",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metr... | Palonosetron may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Oliceridine
Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Promethazine a... |
DB04854 | DB09054 | 1,291 | 384 | [
"DDInter713",
"DDInter905"
] | Febuxostat | Idelalisib | Febuxostat is a non-purine xanthine oxidase (XO) inhibitor. In early 2008, febuxostat was granted marketing authorization by the European Commission for the treatment of chronic hyperuricemia and gout. In the following year, the FDA for approved febuxostat for use in the chronic management of hyperuricemia in adult pat... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
1291,
24,
384
]
],
[
[
1291,
64,
328
],
[
328,
24,
384
]
],
[
[
1291,
63,
305
],
[
305,
24,
384
]
],
[
[
1291,
24,
850
],
[
850,
... | [
[
[
"Febuxostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Febuxostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mercaptopurine"
],
[
"Mercap... | Febuxostat may lead to a major life threatening interaction when taken with Mercaptopurine and Mercaptopurine may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Febuxostat may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia col... |
DB00834 | DB01142 | 932 | 1,264 | [
"DDInter1215",
"DDInter593"
] | Mifepristone | Doxepin | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Major | 2 | [
[
[
932,
25,
1264
]
],
[
[
932,
25,
401
],
[
401,
24,
1264
]
],
[
[
932,
6,
4973
],
[
4973,
45,
1264
]
],
[
[
932,
21,
29226
],
[
29226,
... | [
[
[
"Mifepristone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Doxepin"
]
],
[
[
"Mifepristone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Promethazine"
],
[
"Promethazine",
"... | Mifepristone may lead to a major life threatening interaction when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Mifepristone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Doxepin (Compound)
Mifepristone (Compound) causes Si... |
DB00146 | DB01174 | 160 | 697 | [
"DDInter265",
"DDInter1442"
] | Calcifediol | Phenobarbital | The major circulating metabolite of vitamin D3 (cholecalciferol). It is produced in the liver and is the best indicator of the body's vitamin D stores. It is effective in the treatment of rickets and osteomalacia, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties. | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Moderate | 1 | [
[
[
160,
24,
697
]
],
[
[
160,
24,
759
],
[
759,
1,
697
]
],
[
[
160,
24,
536
],
[
536,
40,
697
]
],
[
[
160,
25,
1098
],
[
1098,
24... | [
[
[
"Calcifediol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenobarbital"
]
],
[
[
"Calcifediol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
],
... | Calcifediol may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone (Compound) resembles Phenobarbital (Compound)
Calcifediol may cause a moderate interaction that could exacerbate diseases when taken with Secobarbital and Secobarbital (Compound) resembles Phenobarbital (... |
DB09075 | DB12141 | 498 | 971 | [
"DDInter621",
"DDInter817"
] | Edoxaban | Gilteritinib | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Major | 2 | [
[
[
498,
25,
971
]
],
[
[
498,
25,
1097
],
[
1097,
24,
971
]
],
[
[
498,
63,
1100
],
[
1100,
24,
971
]
],
[
[
498,
64,
1409
],
[
1409,
... | [
[
[
"Edoxaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gilteritinib"
]
],
[
[
"Edoxaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lasmiditan"
],
[
"Lasmiditan",
"{u} may... | Edoxaban may lead to a major life threatening interaction when taken with Lasmiditan and Lasmiditan may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib
Edoxaban may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine may cause ... |
DB06273 | DB14881 | 980 | 180 | [
"DDInter1824",
"DDInter1329"
] | Tocilizumab | Oliceridine | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Moderate | 1 | [
[
[
980,
24,
180
]
],
[
[
980,
63,
112
],
[
112,
23,
180
]
],
[
[
980,
64,
1184
],
[
1184,
24,
180
]
],
[
[
980,
24,
36
],
[
36,
24,... | [
[
[
"Tocilizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oliceridine"
]
],
[
[
"Tocilizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Tocilizumab may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Oliceridine
Tocilizumab may lead to a major life threatening interaction when taken with Anakinra and Anakinra may cau... |
DB00549 | DB08871 | 522 | 36 | [
"DDInter1955",
"DDInter666"
] | Zafirlukast | Eribulin | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
522,
24,
36
]
],
[
[
522,
63,
1463
],
[
1463,
24,
36
]
],
[
[
522,
24,
1488
],
[
1488,
24,
36
]
],
[
[
522,
23,
479
],
[
479,
24... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lovastatin"
],
[
... | Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Lovastatin and Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine and Fluda... |
DB00382 | DB01001 | 62 | 688 | [
"DDInter1734",
"DDInter1632"
] | Tacrine | Salbutamol | A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market. | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Moderate | 1 | [
[
[
62,
24,
688
]
],
[
[
62,
24,
112
],
[
112,
23,
688
]
],
[
[
62,
24,
543
],
[
543,
24,
688
]
],
[
[
62,
24,
1069
],
[
1069,
63,
... | [
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
]
],
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Salbutamol
Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Loperami... |
DB00086 | DB06605 | 1,167 | 1,409 | [
"DDInter1712",
"DDInter108"
] | Streptokinase | Apixaban | Streptokinase, is a sterile, purified preparation of a bacterial protein elaborated by group C (beta) -hemolytic streptococci. | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Major | 2 | [
[
[
1167,
25,
1409
]
],
[
[
1167,
23,
539
],
[
539,
62,
1409
]
],
[
[
1167,
24,
109
],
[
109,
24,
1409
]
],
[
[
1167,
24,
41
],
[
41,
... | [
[
[
"Streptokinase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apixaban"
]
],
[
[
"Streptokinase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsicum",... | Streptokinase may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Apixaban
Streptokinase may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxetine... |
DB00454 | DB01612 | 1,349 | 1,637 | [
"DDInter1150",
"DDInter92"
] | Meperidine | Amyl Nitrite | A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration. | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Moderate | 1 | [
[
[
1349,
24,
1637
]
],
[
[
1349,
64,
475
],
[
475,
24,
1637
]
],
[
[
1349,
24,
401
],
[
401,
24,
1637
]
],
[
[
1349,
25,
593
],
[
593,
... | [
[
[
"Meperidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Meperidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Morphine"
],
[
"Morphine",... | Meperidine may lead to a major life threatening interaction when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Meperidine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may caus... |
DB00399 | DB00994 | 963 | 361 | [
"DDInter1968",
"DDInter1277"
] | Zoledronic acid | Neomycin | Zoledronic acid, or CGP 42'446, is a third generation, nitrogen containing bisphosphonate similar to [ibandronic acid], [minodronic acid], and [risedronic acid]. Zoledronic acid is used to treat and prevent multiple forms of osteoporosis, hypercalcemia of malignancy, multiple myeloma, bone metastases from solid tumors,... | Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as [framycetin], is the most active component of the complex and neomycin C is the isomer o... | Moderate | 1 | [
[
[
963,
24,
361
]
],
[
[
963,
21,
28722
],
[
28722,
60,
361
]
],
[
[
963,
24,
1132
],
[
1132,
24,
361
]
],
[
[
963,
40,
1485
],
[
1485,
... | [
[
[
"Zoledronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Neomycin"
]
],
[
[
"Zoledronic acid",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is ca... | Zoledronic acid (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Neomycin (Compound)
Zoledronic acid may cause a moderate interaction that could exacerbate diseases when taken with Gentamicin and Gentamicin may cause a moderate interaction that could exacerbate diseases when taken with Neomy... |
DB00795 | DB06402 | 50 | 1,079 | [
"DDInter1725",
"DDInter1756"
] | Sulfasalazine | Telavancin | Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down i... | Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria. MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and skin and sub... | Moderate | 1 | [
[
[
50,
24,
1079
]
],
[
[
50,
63,
91
],
[
91,
1,
1079
]
],
[
[
50,
24,
124
],
[
124,
63,
1079
]
],
[
[
50,
63,
485
],
[
485,
24,
... | [
[
[
"Sulfasalazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telavancin"
]
],
[
[
"Sulfasalazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vancomycin"
],
... | Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Vancomycin and Vancomycin (Compound) resembles Telavancin (Compound)
Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Glasdegib and Glasdegib may cause a moderate interaction that c... |
DB00242 | DB00959 | 1,064 | 1,486 | [
"DDInter392",
"DDInter1191"
] | Cladribine | Methylprednisolone | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Major | 2 | [
[
[
1064,
25,
1486
]
],
[
[
1064,
25,
175
],
[
175,
40,
1486
]
],
[
[
1064,
25,
167
],
[
167,
1,
1486
]
],
[
[
1064,
64,
1351
],
[
1351,
... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Triamcinolone"
],
[
"Triamcinolone"... | Cladribine may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Cladribine may lead to a major life threatening interaction when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Methylprednisolone (Compound)
... |
DB01136 | DB06292 | 772 | 549 | [
"DDInter305",
"DDInter474"
] | Carvedilol | Dapagliflozin | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
772,
24,
549
]
],
[
[
772,
24,
1344
],
[
1344,
40,
549
]
],
[
[
772,
6,
9842
],
[
9842,
45,
549
]
],
[
[
772,
21,
29222
],
[
29222,
... | [
[
[
"Carvedilol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Carvedilol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
... | Carvedilol may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Carvedilol (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Dapagliflozin (Compound)
Carvedilol (Compound) causes Hypoglycaemia (Side Effec... |
DB01005 | DB11817 | 995 | 1,259 | [
"DDInter894",
"DDInter165"
] | Hydroxyurea | Baricitinib | Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, h... | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Major | 2 | [
[
[
995,
25,
1259
]
],
[
[
995,
63,
1461
],
[
1461,
23,
1259
]
],
[
[
995,
24,
949
],
[
949,
24,
1259
]
],
[
[
995,
63,
563
],
[
563,
... | [
[
[
"Hydroxyurea",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Baricitinib"
]
],
[
[
"Hydroxyurea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin ... | Hydroxyurea may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Baricitinib
Hydroxyurea may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani tox... |
DB00420 | DB12245 | 508 | 823 | [
"DDInter1532",
"DDInter1863"
] | Promazine | Triclabendazole | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
508,
24,
823
]
],
[
[
508,
23,
112
],
[
112,
23,
823
]
],
[
[
508,
63,
1010
],
[
1010,
24,
823
]
],
[
[
508,
24,
28
],
[
28,
24,... | [
[
[
"Promazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Promazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Promazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Promazine may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine and M... |
DB00072 | DB08904 | 550 | 375 | [
"DDInter1846",
"DDInter342"
] | Trastuzumab | Certolizumab pegol | Produced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth factor receptor protein (HER2). It is used as a treatment of human epidermal growth ... | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Major | 2 | [
[
[
550,
25,
375
]
],
[
[
550,
24,
200
],
[
200,
63,
375
]
],
[
[
550,
24,
66
],
[
66,
24,
375
]
],
[
[
550,
25,
1066
],
[
1066,
25,... | [
[
[
"Trastuzumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Trastuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
],
[
... | Trastuzumab may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans and Candida albicans may cause a moderate interaction that could exacerbate diseases when taken with Certolizumab pegol
Trastuzumab may cause a moderate interaction that could exacerbate diseases when taken with... |
DB11003 | DB14004 | 748 | 398 | [
"DDInter100",
"DDInter1806"
] | Anthrax vaccine | Tildrakizumab | Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsula... | Tildrakizumab is a high-affinity, humanized, IgG1 κ antibody targeting interleukin 23 p19 that shows promise in the evolution of treatment strategy in chronic plaque psoriasis . The Food and Drug Administration (FDA) approved ILUMYA (tildrakizumab-asmn) for the treatment of adults with moderate-to-severe plaque psorias... | Moderate | 1 | [
[
[
748,
24,
398
]
],
[
[
748,
63,
58
],
[
58,
24,
398
]
],
[
[
748,
24,
270
],
[
270,
24,
398
]
],
[
[
748,
63,
375
],
[
375,
25,
... | [
[
[
"Anthrax vaccine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tildrakizumab"
]
],
[
[
"Anthrax vaccine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alefacept"
... | Anthrax vaccine may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Tildrakizumab
Anthrax vaccine may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizuma... |
DB00209 | DB11130 | 352 | 407 | [
"DDInter1886",
"DDInter1344"
] | Trospium | Opium | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
352,
24,
407
]
],
[
[
352,
24,
662
],
[
662,
24,
407
]
],
[
[
352,
23,
685
],
[
685,
24,
407
]
],
[
[
352,
24,
1536
],
[
1536,
6... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
[
"C... | Trospium may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Trospium may cause a minor interaction that can limit clinical effects when taken with Nitroglycerin and Nitrogly... |
DB00224 | DB06292 | 215 | 549 | [
"DDInter917",
"DDInter474"
] | Indinavir | Dapagliflozin | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem] | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
215,
24,
549
]
],
[
[
215,
24,
1344
],
[
1344,
40,
549
]
],
[
[
215,
6,
8374
],
[
8374,
45,
549
]
],
[
[
215,
21,
28882
],
[
28882,
... | [
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
... | Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Indinavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dapagliflozin (Compound)
Indinavir (Compound) causes Body temperature increased (... |
DB00696 | DB01017 | 826 | 1,669 | [
"DDInter665",
"DDInter1224"
] | Ergotamine | Minocycline | A vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders. | Minocycline was first described in the literacture in 1966. It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria. Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetr... | Moderate | 1 | [
[
[
826,
24,
1669
]
],
[
[
826,
63,
1572
],
[
1572,
1,
1669
]
],
[
[
826,
63,
1545
],
[
1545,
40,
1669
]
],
[
[
826,
24,
1620
],
[
1620,
... | [
[
[
"Ergotamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Minocycline"
]
],
[
[
"Ergotamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Demeclocycline"
],
... | Ergotamine may cause a moderate interaction that could exacerbate diseases when taken with Demeclocycline and Demeclocycline (Compound) resembles Minocycline (Compound)
Ergotamine may cause a moderate interaction that could exacerbate diseases when taken with Oxytetracycline and Oxytetracycline (Compound) resembles Min... |
DB00635 | DB01263 | 1,573 | 859 | [
"DDInter1515",
"DDInter1494"
] | Prednisone | Posaconazole | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Moderate | 1 | [
[
[
1573,
24,
859
]
],
[
[
1573,
6,
4973
],
[
4973,
45,
859
]
],
[
[
1573,
21,
28762
],
[
28762,
60,
859
]
],
[
[
1573,
63,
1101
],
[
1101... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Posaconazole"
]
],
[
[
"Prednisone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",... | Prednisone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Posaconazole (Compound)
Prednisone (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Posaconazole (Compound)
Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexa... |
DB00722 | DB01246 | 743 | 820 | [
"DDInter1079",
"DDInter45"
] | Lisinopril | Alimemazine | Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction.[L8384,L8387,L8390] Lisinopril and [captopril] are the only ACEIs that are not prodrugs. It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldos... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
743,
24,
820
]
],
[
[
743,
24,
104
],
[
104,
40,
820
]
],
[
[
743,
24,
401
],
[
401,
24,
820
]
],
[
[
743,
21,
28662
],
[
28662,
... | [
[
[
"Lisinopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Lisinopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
[... | Lisinopril may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (Compound)
Lisinopril may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction t... |
DB00704 | DB12001 | 267 | 564 | [
"DDInter1263",
"DDInter7"
] | Naltrexone | Abemaciclib | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Moderate | 1 | [
[
[
267,
24,
564
]
],
[
[
267,
24,
868
],
[
868,
24,
564
]
],
[
[
267,
63,
600
],
[
600,
24,
564
]
],
[
[
267,
24,
242
],
[
242,
63,... | [
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abemaciclib"
]
],
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
],
[
... | Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fl... |
DB00818 | DB09330 | 898 | 985 | [
"DDInter1538",
"DDInter1352"
] | Propofol | Osimertinib | Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associate... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Moderate | 1 | [
[
[
898,
24,
985
]
],
[
[
898,
23,
112
],
[
112,
23,
985
]
],
[
[
898,
24,
480
],
[
480,
24,
985
]
],
[
[
898,
24,
657
],
[
657,
63,... | [
[
[
"Propofol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osimertinib"
]
],
[
[
"Propofol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Propofol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Propofol may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formote... |
DB00413 | DB08824 | 1,346 | 591 | [
"DDInter1505",
"DDInter959"
] | Pramipexole | Ioflupane I-123 | Pramipexole is a drug used to treat the symptoms of Parkinson's Disease (PD). It is a _non-ergot dopamine agonist_ drug that is efficacious in treating various Parkinson's symptoms such as tremor, rigidity, and bradykinesia (slow movement). It was first approved by the FDA in 1997. Parkinson's Disease is one of the mos... | Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes. | Moderate | 1 | [
[
[
1346,
24,
591
]
],
[
[
1346,
21,
29305
],
[
29305,
60,
591
]
],
[
[
1346,
24,
401
],
[
401,
24,
591
]
],
[
[
1346,
63,
999
],
[
999,
... | [
[
[
"Pramipexole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioflupane I-123"
]
],
[
[
"Pramipexole",
"{u} (Compound) causes {v} (Side Effect)",
"Dysgeusia"
],
[
"Dysgeusia",
"{u} (Side Effect) ... | Pramipexole (Compound) causes Dysgeusia (Side Effect) and Dysgeusia (Side Effect) is caused by Ioflupane I-123 (Compound)
Pramipexole may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00242 | DB10276 | 1,064 | 1,624 | [
"DDInter392",
"DDInter1623"
] | Cladribine | Rotavirus vaccine | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Major | 2 | [
[
[
1064,
25,
1624
]
],
[
[
1064,
25,
617
],
[
617,
24,
1624
]
],
[
[
1064,
25,
552
],
[
552,
25,
1624
]
],
[
[
1064,
64,
1648
],
[
1648,
... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Budesonide"
],
[
"Budesonide",
... | Cladribine may lead to a major life threatening interaction when taken with Budesonide and Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Rotavirus vaccine
Cladribine may lead to a major life threatening interaction when taken with Carmustine and Carmustine may lead to a majo... |
DB00907 | DB01255 | 290 | 633 | [
"DDInter427",
"DDInter1078"
] | Cocaine (topical) | Lisdexamfetamine | Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts. | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Major | 2 | [
[
[
290,
25,
633
]
],
[
[
290,
64,
551
],
[
551,
1,
633
]
],
[
[
290,
64,
80
],
[
80,
40,
633
]
],
[
[
290,
25,
1529
],
[
1529,
1,
... | [
[
[
"Cocaine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lisdexamfetamine"
]
],
[
[
"Cocaine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phenelzine"
],
[
"Phenelzine",
"{u} (... | Cocaine may lead to a major life threatening interaction when taken with Lisdexamfetamine
Cocaine may lead to a major life threatening interaction when taken with Phenelzine and Phenelzine (Compound) resembles Lisdexamfetamine (Compound)
Cocaine may lead to a major life threatening interaction when taken with Amphetami... |
DB00472 | DB11703 | 758 | 405 | [
"DDInter758",
"DDInter9"
] | Fluoxetine | Acalabrutinib | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Moderate | 1 | [
[
[
758,
24,
405
]
],
[
[
758,
25,
982
],
[
982,
63,
405
]
],
[
[
758,
24,
1297
],
[
1297,
63,
405
]
],
[
[
758,
24,
918
],
[
918,
2... | [
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Fluoxetine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
],
[
"Ivoside... | Fluoxetine may lead to a major life threatening interaction when taken with Ivosidenib and Ivosidenib may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Osilodrostat and Osilodrostat may... |
DB00814 | DB01225 | 1,171 | 500 | [
"DDInter1143",
"DDInter645"
] | Meloxicam | Enoxaparin | Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is ... | Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies. Enoxaparin markedly reduces the inc... | Major | 2 | [
[
[
1171,
25,
500
]
],
[
[
1171,
21,
29173
],
[
29173,
60,
500
]
],
[
[
1171,
24,
1039
],
[
1039,
24,
500
]
],
[
[
1171,
63,
305
],
[
305,... | [
[
[
"Meloxicam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enoxaparin"
]
],
[
[
"Meloxicam",
"{u} (Compound) causes {v} (Side Effect)",
"Oedema peripheral"
],
[
"Oedema peripheral",
"{u} (Side Effect) is cause... | Meloxicam (Compound) causes Oedema peripheral (Side Effect) and Oedema peripheral (Side Effect) is caused by Enoxaparin (Compound)
Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine and Dexfenfluramine may cause a moderate interaction that could exacerbate diseases... |
DB01254 | DB09389 | 1,213 | 517 | [
"DDInter484",
"DDInter1315"
] | Dasatinib | Norgestrel | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Norgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantiomer ([levonorgestrel]) is biologically active. | Moderate | 1 | [
[
[
1213,
24,
517
]
],
[
[
1213,
24,
159
],
[
159,
63,
517
]
],
[
[
1213,
63,
86
],
[
86,
24,
517
]
],
[
[
1213,
64,
581
],
[
581,
2... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norgestrel"
]
],
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
[
... | Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Norgestrel
Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Miconazole and Mi... |
DB00661 | DB01285 | 122 | 708 | [
"DDInter1928",
"DDInter445"
] | Verapamil | Corticotropin | Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Moderate | 1 | [
[
[
122,
24,
708
]
],
[
[
122,
63,
1324
],
[
1324,
24,
708
]
],
[
[
122,
24,
1450
],
[
1450,
63,
708
]
],
[
[
122,
24,
473
],
[
473,
... | [
[
[
"Verapamil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
]
],
[
[
"Verapamil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troglitazone"
],
[... | Verapamil may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin
Verapamil may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin an... |
DB00928 | DB09498 | 1,426 | 810 | [
"DDInter148",
"DDInter1715"
] | Azacitidine | Strontium chloride Sr-89 | Azacitidine is a pyrimidine nucleoside analogue with anti-neoplastic activity. It differs from cytosine by the presence of nitrogen in the C5-position, key in its hypomethylating activity.[A1406,A1413,A1415] Two main mechanisms of action have been proposed for azacitidine. One of them is the induction of cytotoxicity. ... | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Moderate | 1 | [
[
[
1426,
24,
810
]
],
[
[
1426,
63,
597
],
[
597,
24,
810
]
],
[
[
1426,
1,
1224
],
[
1224,
24,
810
]
],
[
[
1426,
24,
869
],
[
869,
... | [
[
[
"Azacitidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Strontium chloride Sr-89"
]
],
[
[
"Azacitidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphen... | Azacitidine may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89
Azacitidine (Compound) resembles Cytarabine (Compound) and Cytarabine may cause a moder... |
DB08896 | DB12825 | 292 | 1,375 | [
"DDInter1576",
"DDInter1032"
] | Regorafenib | Lefamulin | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Moderate | 1 | [
[
[
292,
24,
1375
]
],
[
[
292,
24,
159
],
[
159,
63,
1375
]
],
[
[
292,
24,
98
],
[
98,
24,
1375
]
],
[
[
292,
25,
1468
],
[
1468,
... | [
[
[
"Regorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
]
],
[
[
"Regorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
... | Regorafenib may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin
Regorafenib may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and S... |
DB00981 | DB01242 | 1,528 | 1,237 | [
"DDInter1463",
"DDInter410"
] | Physostigmine (ophthalmic) | Clomipramine | Physostigmine is a carbamate ester and an indole alkaloid. It has a role as a miotic, an EC 3.1.1.8 (cholinesterase) inhibitor and an antidote to curare poisoning. | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Moderate | 1 | [
[
[
1528,
24,
1237
]
],
[
[
1528,
63,
684
],
[
684,
1,
1237
]
],
[
[
1528,
24,
272
],
[
272,
24,
1237
]
],
[
[
1528,
63,
146
],
[
146,
... | [
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
]
],
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thioridazine"
]... | Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine
Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Thioridazine and Thioridazine (Compound) resembles Clomipramine (Compound)
Physostigmine may cause a moderate interacti... |
DB06799 | DB09268 | 212 | 1,662 | [
"DDInter1169",
"DDInter1464"
] | Methenamine | Picosulfuric acid | Methenamine is a heterocyclic organic compound with a cage-like structure similar to adamantane. In salt form it is used for the treatment of urinary tract infection (Example: methenamine hippurate which is the hippuric acid salt of methenamine). | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
212,
24,
1662
]
],
[
[
212,
63,
1283
],
[
1283,
62,
743
],
[
743,
24,
1662
]
],
[
[
212,
24,
1384
],
[
1384,
62,
167
],
[
167,
24,
... | [
[
[
"Methenamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Methenamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium oxide"
... | Methenamine may cause a moderate interaction that could exacerbate diseases when taken with Magnesium oxide and Magnesium oxide may cause a minor interaction that can limit clinical effects when taken with Lisinopril and Lisinopril may cause a moderate interaction that could exacerbate diseases when taken with Picosulf... |
DB00328 | DB00863 | 831 | 1,194 | [
"DDInter921",
"DDInter1568"
] | Indomethacin | Ranitidine | Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlor... | Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as [cimetidine] and [famotidine]. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.[A176759,L10818]... | Minor | 0 | [
[
[
831,
23,
1194
]
],
[
[
831,
23,
1127
],
[
1127,
1,
1194
]
],
[
[
831,
6,
16560
],
[
16560,
45,
1194
]
],
[
[
831,
21,
28701
],
[
28701... | [
[
[
"Indomethacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ranitidine"
]
],
[
[
"Indomethacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Nizatidine"
],
[
... | Indomethacin may cause a minor interaction that can limit clinical effects when taken with Nizatidine and Nizatidine (Compound) resembles Ranitidine (Compound)
Indomethacin (Compound) binds SLC22A8 (Gene) and SLC22A8 (Gene) is bound by Ranitidine (Compound)
Indomethacin (Compound) causes Discomfort (Side Effect) and Di... |
DB00087 | DB01181 | 599 | 1,532 | [
"DDInter41",
"DDInter906"
] | Alemtuzumab | Ifosfamide | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
599,
24,
1532
]
],
[
[
599,
63,
1648
],
[
1648,
24,
1532
]
],
[
[
599,
24,
1330
],
[
1330,
63,
1532
]
],
[
[
599,
24,
0
],
[
0,
... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
],
[... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Naxitamab and Nax... |
DB01181 | DB01233 | 1,532 | 1,311 | [
"DDInter906",
"DDInter1197"
] | Ifosfamide | Metoclopramide | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Moderate | 1 | [
[
[
1532,
24,
1311
]
],
[
[
1532,
21,
28691
],
[
28691,
60,
1311
]
],
[
[
1532,
24,
643
],
[
643,
63,
1311
]
],
[
[
1532,
63,
629
],
[
629... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
]
],
[
[
"Ifosfamide",
"{u} (Compound) causes {v} (Side Effect)",
"Somnolence"
],
[
"Somnolence",
"{u} (Side Effect) i... | Ifosfamide (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Metoclopramide (Compound)
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Desvenlafaxine and Desvenlafaxine may cause a moderate interaction that could exacerbate diseases when take... |
DB00486 | DB01080 | 1,614 | 855 | [
"DDInter1253",
"DDInter1933"
] | Nabilone | Vigabatrin | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Vigabatrin is an analog of gamma-aminobutyric acid ([GABA]), the main inhibitory neurotransmitter in the central nervous system, used in the treatment of refractory seizures and infantile spasms. It irreversibly inhibits the enzyme responsible for GABA metabolism, thereby increasing levels of circulating GABA. Although... | Moderate | 1 | [
[
[
1614,
24,
855
]
],
[
[
1614,
21,
28975
],
[
28975,
60,
855
]
],
[
[
1614,
24,
407
],
[
407,
63,
855
]
],
[
[
1614,
24,
401
],
[
401,
... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vigabatrin"
]
],
[
[
"Nabilone",
"{u} (Compound) causes {v} (Side Effect)",
"Tension"
],
[
"Tension",
"{u} (Side Effect) is caused by {v... | Nabilone (Compound) causes Tension (Side Effect) and Tension (Side Effect) is caused by Vigabatrin (Compound)
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause a moderate interaction that could exacerbate diseases when taken with Vigabatrin
Nabilone may c... |
DB00263 | DB00414 | 1,029 | 590 | [
"DDInter1727",
"DDInter16"
] | Sulfisoxazole | Acetohexamide | A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms. | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Moderate | 1 | [
[
[
1029,
24,
590
]
],
[
[
1029,
63,
176
],
[
176,
24,
590
]
],
[
[
1029,
24,
1254
],
[
1254,
63,
590
]
],
[
[
1029,
1,
1247
],
[
1247,
... | [
[
[
"Sulfisoxazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetohexamide"
]
],
[
[
"Sulfisoxazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glargine"
... | Sulfisoxazole may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine and Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide
Sulfisoxazole may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00443 | DB01149 | 251 | 851 | [
"DDInter195",
"DDInter1274"
] | Betamethasone | Nefazodone | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Moderate | 1 | [
[
[
251,
24,
851
]
],
[
[
251,
6,
8374
],
[
8374,
45,
851
]
],
[
[
251,
7,
4759
],
[
4759,
46,
851
]
],
[
[
251,
18,
3677
],
[
3677,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nefazodone"
]
],
[
[
"Betamethasone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compo... | Betamethasone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nefazodone (Compound)
Betamethasone (Compound) upregulates SERPINA3 (Gene) and SERPINA3 (Gene) is upregulated by Nefazodone (Compound)
Betamethasone (Compound) downregulates NFKBIE (Gene) and NFKBIE (Gene) is upregulated by Nefazodone (Compound)... |
DB09039 | DB13179 | 1,670 | 68 | [
"DDInter629",
"DDInter1882"
] | Eliglustat | Troleandomycin | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | A macrolide antibiotic that is similar to erythromycin. | Major | 2 | [
[
[
1670,
25,
68
]
],
[
[
1670,
63,
1413
],
[
1413,
23,
68
]
],
[
[
1670,
64,
1374
],
[
1374,
23,
68
]
],
[
[
1670,
63,
973
],
[
973,
... | [
[
[
"Eliglustat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Troleandomycin"
]
],
[
[
"Eliglustat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fexofenadine"
],
[
"Fexo... | Eliglustat may cause a moderate interaction that could exacerbate diseases when taken with Fexofenadine and Fexofenadine may cause a minor interaction that can limit clinical effects when taken with Troleandomycin
Eliglustat may lead to a major life threatening interaction when taken with Abiraterone and Abiraterone ma... |
DB00450 | DB06663 | 78 | 1,154 | [
"DDInter603",
"DDInter1398"
] | Droperidol | Pasireotide | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
78,
25,
1154
]
],
[
[
78,
21,
29024
],
[
29024,
60,
1154
]
],
[
[
78,
23,
112
],
[
112,
23,
1154
]
],
[
[
78,
25,
1662
],
[
1662,
... | [
[
[
"Droperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Droperidol",
"{u} (Compound) causes {v} (Side Effect)",
"Hypertension"
],
[
"Hypertension",
"{u} (Side Effect) is caused by {v... | Droperidol (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Pasireotide (Compound)
Droperidol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken wit... |
DB00964 | DB06691 | 1,617 | 849 | [
"DDInter110",
"DDInter1155"
] | Apraclonidine | Mepyramine | Apraclonidine, also known as iopidine, is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist. | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
1617,
24,
849
]
],
[
[
1617,
63,
1594
],
[
1594,
24,
849
]
],
[
[
1617,
24,
272
],
[
272,
24,
849
]
],
[
[
1617,
24,
407
],
[
407,
... | [
[
[
"Apraclonidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Apraclonidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
... | Apraclonidine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Apraclonidine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramin... |
DB00405 | DB01618 | 128 | 776 | [
"DDInter517",
"DDInter1239"
] | Dexbrompheniramine | Molindone | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to mo... | Moderate | 1 | [
[
[
128,
24,
776
]
],
[
[
128,
24,
100
],
[
100,
24,
776
]
],
[
[
128,
24,
1511
],
[
1511,
63,
776
]
],
[
[
128,
63,
999
],
[
999,
2... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Molindone"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniram... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Molindone
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken w... |
DB01175 | DB04932 | 318 | 1,564 | [
"DDInter672",
"DDInter491"
] | Escitalopram | Defibrotide | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Da... | Moderate | 1 | [
[
[
318,
24,
1564
]
],
[
[
318,
25,
1039
],
[
1039,
24,
1564
]
],
[
[
318,
63,
714
],
[
714,
24,
1564
]
],
[
[
318,
24,
885
],
[
885,
... | [
[
[
"Escitalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Defibrotide"
]
],
[
[
"Escitalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexfenfluramine"
],
[
"... | Escitalopram may lead to a major life threatening interaction when taken with Dexfenfluramine and Dexfenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Defibrotide
Escitalopram may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost... |
DB01261 | DB14730 | 170 | 1,412 | [
"DDInter1679",
"DDInter264"
] | Sitagliptin | Calaspargase pegol | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
170,
24,
1412
]
],
[
[
170,
63,
1144
],
[
1144,
24,
1412
]
],
[
[
170,
24,
868
],
[
868,
24,
1412
]
],
[
[
170,
23,
52
],
[
52,
... | [
[
[
"Sitagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Sitagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
... | Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Vemurafen... |
DB00087 | DB06176 | 599 | 1,342 | [
"DDInter41",
"DDInter1616"
] | Alemtuzumab | Romidepsin | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Moderate | 1 | [
[
[
599,
24,
1342
]
],
[
[
599,
24,
485
],
[
485,
24,
1342
]
],
[
[
599,
24,
1491
],
[
1491,
63,
1342
]
],
[
[
599,
63,
1257
],
[
1257,
... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romidepsin"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentamidine"
],
[... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine and Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin and M... |
DB00888 | DB08895 | 1,001 | 976 | [
"DDInter1133",
"DDInter1825"
] | Mechlorethamine | Tofacitinib | A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. The FDA granted marketing approval f... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
1001,
25,
976
]
],
[
[
1001,
63,
1461
],
[
1461,
23,
976
]
],
[
[
1001,
24,
200
],
[
200,
63,
976
]
],
[
[
1001,
24,
1430
],
[
1430,
... | [
[
[
"Mechlorethamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Mechlorethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"... | Mechlorethamine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Tofacitinib
Mechlorethamine may cause a moderate interaction that could exacerbate diseases when taken with Candida albica... |
DB00019 | DB09208 | 1,257 | 934 | [
"DDInter1405",
"DDInter1410"
] | Pegfilgrastim | Pegloticase | Pegfilgrastim is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (G-CSF) analogue, [filgrastim]. The drug is approved for use to decrease the incidence of infection, as manifested by febrile neutropenia, in susceptible patients with with non-myeloid cancer receiving myelosuppressive anti... | Pegloticase is a porcine recombinant PEGylated uricase indicated for the treatment of chronic gout in adult patients that do not respond to other types of therapies. Pegloticase has a similar activity to rasburicase, an enzyme that metabolizes uric acid to allantoin. In gout patients treated with pegloticase, the conve... | Moderate | 1 | [
[
[
1257,
24,
934
]
],
[
[
1257,
24,
1560
],
[
1560,
24,
934
]
],
[
[
1257,
24,
919
],
[
919,
63,
934
]
],
[
[
1257,
63,
491
],
[
491,
... | [
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pegloticase"
]
],
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pegaspargase"
],... | Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase and Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Pegloticase
Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Pegvaliase... |
DB00352 | DB01033 | 482 | 328 | [
"DDInter1814",
"DDInter1156"
] | Tioguanine | Mercaptopurine | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. | Moderate | 1 | [
[
[
482,
35,
328
]
],
[
[
482,
40,
11444
],
[
11444,
1,
328
]
],
[
[
482,
5,
11555
],
[
11555,
44,
328
]
],
[
[
482,
6,
7129
],
[
7129,
... | [
[
[
"Tioguanine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mercaptopurine"
]
],
[
[
"Tioguanine",
"{u} (Compound) resembles {v} (Compound)",
"Adenine"
],
[
... | Tioguanine (Compound) resembles Mercaptopurine (Compound) and
Tioguanine (Compound) resembles Adenine (Compound) and Adenine (Compound) resembles Mercaptopurine (Compound)
Tioguanine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Mercaptopurine (Compound)
Tioguanine (Compo... |
DB00637 | DB00656 | 1,557 | 827 | [
"DDInter128",
"DDInter1851"
] | Astemizole | Trazodone | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | Moderate | 1 | [
[
[
1557,
24,
827
]
],
[
[
1557,
24,
623
],
[
623,
40,
827
]
],
[
[
1557,
24,
1630
],
[
1630,
1,
827
]
],
[
[
1557,
63,
252
],
[
252,
... | [
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trazodone"
]
],
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quetiapine"
],
[
... | Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Quetiapine and Quetiapine (Compound) resembles Trazodone (Compound)
Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Perphenazine and Perphenazine (Compound) resembles Trazodone (Compound... |
DB08895 | DB11248 | 976 | 1,193 | [
"DDInter1825",
"DDInter1965"
] | Tofacitinib | Zinc gluconate | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA . It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration of common colds and wi... | Minor | 0 | [
[
[
976,
23,
1193
]
],
[
[
976,
64,
1096
],
[
1096,
23,
1193
]
],
[
[
976,
25,
725
],
[
725,
62,
1193
]
],
[
[
976,
25,
812
],
[
812,
... | [
[
[
"Tofacitinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
]
],
[
[
"Tofacitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mycophenolic acid"
],
[
... | Tofacitinib may lead to a major life threatening interaction when taken with Mycophenolic acid and Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate
Tofacitinib may lead to a major life threatening interaction when taken with Satralizumab and Satralizumab may... |
DB08871 | DB10316 | 36 | 334 | [
"DDInter666",
"DDInter1248"
] | Eribulin | Mumps virus strain B level jeryl lynn live antigen | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
36,
25,
334
]
],
[
[
36,
63,
594
],
[
594,
25,
334
]
],
[
[
36,
64,
1057
],
[
1057,
25,
334
]
],
[
[
36,
25,
976
],
[
976,
25,
... | [
[
[
"Eribulin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Eribulin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosuti... | Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Bosutinib and Bosutinib may lead to a major life threatening interaction when taken with Mumps virus strain B level jeryl lynn live antigen
Eribulin may lead to a major life threatening interaction when taken with Etanercept and Et... |
DB01236 | DB01246 | 679 | 820 | [
"DDInter1664",
"DDInter45"
] | Sevoflurane | Alimemazine | Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 199... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
679,
24,
820
]
],
[
[
679,
63,
401
],
[
401,
24,
820
]
],
[
[
679,
6,
8374
],
[
8374,
45,
820
]
],
[
[
679,
21,
29339
],
[
29339,
... | [
[
[
"Sevoflurane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Sevoflurane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
... | Sevoflurane may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Sevoflurane (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Alimemazine (Compound)
Sevofluran... |
DB00475 | DB00792 | 1,119 | 832 | [
"DDInter355",
"DDInter1878"
] | Chlordiazepoxide | Tripelennamine | An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal. | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Moderate | 1 | [
[
[
1119,
24,
832
]
],
[
[
1119,
24,
100
],
[
100,
63,
832
]
],
[
[
1119,
24,
649
],
[
649,
1,
832
]
],
[
[
1119,
63,
1594
],
[
1594,
... | [
[
[
"Chlordiazepoxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
]
],
[
[
"Chlordiazepoxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bromphenira... | Chlordiazepoxide may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine
Chlordiazepoxide may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00376 | DB00981 | 1,105 | 1,528 | [
"DDInter1870",
"DDInter1463"
] | Trihexyphenidyl | Physostigmine (ophthalmic) | Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced extrapyramidal disorders.[L31773,L31778] Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity. Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is n... | Physostigmine is a carbamate ester and an indole alkaloid. It has a role as a miotic, an EC 3.1.1.8 (cholinesterase) inhibitor and an antidote to curare poisoning. | Moderate | 1 | [
[
[
1105,
24,
1528
]
],
[
[
1105,
21,
28658
],
[
28658,
60,
1528
]
],
[
[
1105,
24,
1511
],
[
1511,
63,
1528
]
],
[
[
1105,
24,
543
],
[
5... | [
[
[
"Trihexyphenidyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Physostigmine"
]
],
[
[
"Trihexyphenidyl",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Effe... | Trihexyphenidyl may cause a moderate interaction that could exacerbate diseases when taken with Physostigmine
Trihexyphenidyl (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Physostigmine (Compound)
Trihexyphenidyl may cause a moderate interaction that could exacerbate diseases when tak... |
DB00748 | DB01075 | 662 | 1,376 | [
"DDInter297",
"DDInter569"
] | Carbinoxamine | Diphenhydramine | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
662,
35,
1376
]
],
[
[
662,
35,
649
],
[
649,
63,
1376
]
],
[
[
662,
63,
128
],
[
128,
24,
1376
]
],
[
[
662,
1,
11786
],
[
11786,
... | [
[
[
"Carbinoxamine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Carbinoxamine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate ... | Carbinoxamine (Compound) resembles Diphenhydramine (Compound) and
Carbinoxamine (Compound) resembles Clofedanol (Compound) and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when take... |
DB01394 | DB09052 | 1,554 | 250 | [
"DDInter431",
"DDInter220"
] | Colchicine | Blinatumomab | Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has ... | Blinatumomab is a BiTE-class (bi-specific T-cell engager) constructed monoclonal antibody formed by the recombinant fusion of an anti-CD3 single-chain variable fragment (scFV) and an anti-CD19 scFV through a short peptide linker.[A254836,L44311] CD3 is an antigen expressed on the surface of T-cells, while CD19 is mostl... | Moderate | 1 | [
[
[
1554,
24,
250
]
],
[
[
1554,
24,
1362
],
[
1362,
63,
250
]
],
[
[
1554,
63,
599
],
[
599,
24,
250
]
],
[
[
1554,
24,
850
],
[
850,
... | [
[
[
"Colchicine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Blinatumomab"
]
],
[
[
"Colchicine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[
... | Colchicine may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Blinatumomab
Colchicine may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab and Alemtuz... |
DB00341 | DB00395 | 1,242 | 210 | [
"DDInter343",
"DDInter301"
] | Cetirizine | Carisoprodol | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | Originally approved by the FDA in 1959 [FDA label], carisoprodol is a centrally acting muscle relaxant used in painful musculoskeletal conditions in conjunction with physical therapy and other medications . This drug is available by itself in an oral tablet or combined with aspirin, or in a fixed-dose combination with ... | Moderate | 1 | [
[
[
1242,
24,
210
]
],
[
[
1242,
24,
1050
],
[
1050,
40,
210
]
],
[
[
1242,
21,
28757
],
[
28757,
60,
210
]
],
[
[
1242,
74,
701
],
[
701,... | [
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carisoprodol"
]
],
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meprobamate"
],
[... | Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Meprobamate and Meprobamate (Compound) resembles Carisoprodol (Compound)
Cetirizine (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Carisoprodol (Compound)
Cetirizine (Compound) resembles Clemas... |
DB09104 | DB11613 | 286 | 1,519 | [
"DDInter1118",
"DDInter1924"
] | Magnesium hydroxide | Velpatasvir | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Velpatasvir is a Direct-Acting Antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Moderate | 1 | [
[
[
286,
24,
1519
]
],
[
[
286,
63,
1374
],
[
1374,
24,
1519
]
],
[
[
286,
62,
1559
],
[
1559,
24,
1519
]
],
[
[
286,
24,
460
],
[
460,
... | [
[
[
"Magnesium hydroxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Velpatasvir"
]
],
[
[
"Magnesium hydroxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abirater... | Magnesium hydroxide may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone may cause a moderate interaction that could exacerbate diseases when taken with Velpatasvir
Magnesium hydroxide may cause a minor interaction that can limit clinical effects when taken with Fa... |
DB09083 | DB13074 | 880 | 877 | [
"DDInter996",
"DDInter1110"
] | Ivabradine | Macimorelin | Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus r... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Major | 2 | [
[
[
880,
25,
877
]
],
[
[
880,
24,
1320
],
[
1320,
24,
877
]
],
[
[
880,
25,
913
],
[
913,
24,
877
]
],
[
[
880,
63,
1101
],
[
1101,
... | [
[
[
"Ivabradine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Macimorelin"
]
],
[
[
"Ivabradine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
],
[
"Elagolix",
... | Ivabradine may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elagolix may cause a moderate interaction that could exacerbate diseases when taken with Macimorelin
Ivabradine may lead to a major life threatening interaction when taken with Apalutamide and Apalutamide may cause a... |
DB00468 | DB11691 | 1,424 | 1,499 | [
"DDInter1557",
"DDInter1258"
] | Quinine | Naldemedine | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Naldemedine is an opioid receptor antagonist [FDA Label]. It is a modified form of to which a side chain has been added to increase molecular weight and polar surface area resulting in restricted transport across the blood brain barrier. Naldemedine was approved in 2017 in both the US and Japan for the treatment of Opi... | Moderate | 1 | [
[
[
1424,
24,
1499
]
],
[
[
1424,
23,
307
],
[
307,
23,
1499
]
],
[
[
1424,
25,
932
],
[
932,
24,
1499
]
],
[
[
1424,
24,
723
],
[
723,
... | [
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naldemedine"
]
],
[
[
"Quinine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
],
[
"Mod... | Quinine may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Naldemedine
Quinine may lead to a major life threatening interaction when taken with Mifepristone and Mifepristone may cause a moder... |
DB00241 | DB00675 | 288 | 888 | [
"DDInter257",
"DDInter1744"
] | Butalbital | Tamoxifen | Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervou... | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Moderate | 1 | [
[
[
288,
24,
888
]
],
[
[
288,
24,
832
],
[
832,
40,
888
]
],
[
[
288,
24,
649
],
[
649,
1,
888
]
],
[
[
288,
24,
1376
],
[
1376,
64... | [
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tamoxifen"
]
],
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
],
[... | Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tripelennamine (Compound) resembles Tamoxifen (Compound)
Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol (Compound) resembles Tamoxifen (Comp... |
DB00023 | DB00459 | 305 | 640 | [
"DDInter127",
"DDInter21"
] | Asparaginase Escherichia coli | Acitretin | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate. | Moderate | 1 | [
[
[
305,
24,
640
]
],
[
[
305,
24,
1517
],
[
1517,
64,
640
]
],
[
[
305,
24,
267
],
[
267,
63,
640
]
],
[
[
305,
24,
912
],
[
912,
2... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acitretin"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Isotretinoin and Isotretinoin may lead to a major life threatening interaction when taken with Acitretin
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00731 | DB00861 | 1,144 | 914 | [
"DDInter1269",
"DDInter551"
] | Nateglinide | Diflunisal | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | Moderate | 1 | [
[
[
1144,
24,
914
]
],
[
[
1144,
24,
712
],
[
712,
63,
914
]
],
[
[
1144,
6,
10612
],
[
10612,
45,
914
]
],
[
[
1144,
21,
28658
],
[
28658... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diflunisal"
]
],
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olsalazine"
],
[
... | Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Olsalazine and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Diflunisal
Nateglinide (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Diflunisal (Compound)
Nateglinide (C... |
DB00662 | DB01238 | 717 | 673 | [
"DDInter1873",
"DDInter118"
] | Trimethobenzamide | Aripiprazole | Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against e... | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Moderate | 1 | [
[
[
717,
24,
673
]
],
[
[
717,
24,
851
],
[
851,
1,
673
]
],
[
[
717,
63,
827
],
[
827,
40,
673
]
],
[
[
717,
21,
28762
],
[
28762,
... | [
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aripiprazole"
]
],
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nefazodone"... | Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Nefazodone and Nefazodone (Compound) resembles Aripiprazole (Compound)
Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Trazodone and Trazodone (Compound) resembles Aripipra... |
DB01246 | DB01320 | 820 | 651 | [
"DDInter45",
"DDInter783"
] | Alimemazine | Fosphenytoin | A phenothiazine derivative that is used as an antipruritic. | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Moderate | 1 | [
[
[
820,
24,
651
]
],
[
[
820,
63,
362
],
[
362,
1,
651
]
],
[
[
820,
6,
8374
],
[
8374,
45,
651
]
],
[
[
820,
21,
28800
],
[
28800,
... | [
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
[... | Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Compound)
Alimemazine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fosphenytoin (Compound)
Alimemazine (Compound) causes Dyskinesia (Side Effect) and Dys... |
DB00312 | DB00434 | 1,023 | 13 | [
"DDInter1423",
"DDInter459"
] | Pentobarbital | Cyproheptadine | A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Dr... | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Moderate | 1 | [
[
[
1023,
24,
13
]
],
[
[
1023,
24,
104
],
[
104,
63,
13
]
],
[
[
1023,
18,
7630
],
[
7630,
46,
13
]
],
[
[
1023,
21,
28789
],
[
28789,
... | [
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
]
],
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
... | Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine
Pentobarbital (Compound) downregulates TXLNA (Gene) and TXLNA (Gene) is upregulated by Cyproheptadine... |
DB01165 | DB01168 | 1,539 | 1,053 | [
"DDInter1325",
"DDInter1526"
] | Ofloxacin | Procarbazine | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Minor | 0 | [
[
[
1539,
23,
1053
]
],
[
[
1539,
63,
848
],
[
848,
40,
1053
]
],
[
[
1539,
21,
28762
],
[
28762,
60,
1053
]
],
[
[
1539,
40,
246
],
[
246... | [
[
[
"Ofloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Procarbazine"
]
],
[
[
"Ofloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
],
[
... | Ofloxacin may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen (Compound) resembles Procarbazine (Compound)
Ofloxacin (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Procarbazine (Compound)
Ofloxacin (Compound) resembles Gatifloxacin (C... |
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