drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB12015 | DB12095 | 1,033 | 179 | [
"DDInter53",
"DDInter1760"
] | Alpelisib | Telotristat ethyl | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α, which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metabolis... | Telotristat ethyl is a prodrug of telotristat that was approved by the FDA in March 2017 as Xermelo. It was previously referred to as telotristat etiprate, the hippurate salt form; however, the FDA recommends the use of the name of the neutral form rather than that of the salt.[A252937, A252942] Currently, telotristat ... | Moderate | 1 | [
[
[
1033,
24,
179
]
],
[
[
1033,
63,
1517
],
[
1517,
24,
179
]
],
[
[
1033,
24,
971
],
[
971,
63,
179
]
],
[
[
1033,
64,
129
],
[
129,
... | [
[
[
"Alpelisib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telotristat ethyl"
]
],
[
[
"Alpelisib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isotretinoin"
],
... | Alpelisib may cause a moderate interaction that could exacerbate diseases when taken with Isotretinoin and Isotretinoin may cause a moderate interaction that could exacerbate diseases when taken with Telotristat ethyl
Alpelisib may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib... |
DB01035 | DB11817 | 1,401 | 1,259 | [
"DDInter1524",
"DDInter165"
] | Procainamide | Baricitinib | A derivative of procaine with less CNS action. | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Major | 2 | [
[
[
1401,
25,
1259
]
],
[
[
1401,
25,
927
],
[
927,
24,
1259
]
],
[
[
1401,
25,
1619
],
[
1619,
64,
1259
]
],
[
[
1401,
25,
36
],
[
36,
... | [
[
[
"Procainamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Baricitinib"
]
],
[
[
"Procainamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
],
[
"Encorafenib",
... | Procainamide may lead to a major life threatening interaction when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Baricitinib
Procainamide may lead to a major life threatening interaction when taken with Rucaparib and Rucaparib may lead to a major ... |
DB01069 | DB01166 | 401 | 477 | [
"DDInter1533",
"DDInter379"
] | Promethazine | Cilostazol | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Moderate | 1 | [
[
[
401,
24,
477
]
],
[
[
401,
6,
12523
],
[
12523,
45,
477
]
],
[
[
401,
21,
28642
],
[
28642,
60,
477
]
],
[
[
401,
24,
801
],
[
801,
... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
]
],
[
[
"Promethazine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compoun... | Promethazine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Cilostazol (Compound)
Promethazine (Compound) causes Shock (Side Effect) and Shock (Side Effect) is caused by Cilostazol (Compound)
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Brivaracetam and Briv... |
DB08815 | DB08912 | 154 | 1,040 | [
"DDInter1104",
"DDInter462"
] | Lurasidone | Dabrafenib | Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States. | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
154,
24,
1040
]
],
[
[
154,
6,
8374
],
[
8374,
45,
1040
]
],
[
[
154,
21,
28900
],
[
28900,
60,
1040
]
],
[
[
154,
63,
1101
],
[
1101,... | [
[
[
"Lurasidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Lurasidone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Lurasidone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dabrafenib (Compound)
Lurasidone (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Dabrafenib (Compound)
Lurasidone may cause a moderate interaction that could exacerbate diseases when taken with Bexaroten... |
DB00867 | DB01087 | 1,052 | 1,520 | [
"DDInter1606",
"DDInter1520"
] | Ritodrine | Primaquine | Adrenergic beta-agonist used to control premature labor. | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Moderate | 1 | [
[
[
1052,
24,
1520
]
],
[
[
1052,
24,
1487
],
[
1487,
64,
1520
]
],
[
[
1052,
24,
1342
],
[
1342,
63,
1520
]
],
[
[
1052,
24,
1133
],
[
11... | [
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
]
],
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
],
... | Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Hydroxychloroquine and Hydroxychloroquine may lead to a major life threatening interaction when taken with Primaquine
Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin and Romidep... |
DB00995 | DB01098 | 1,112 | 14 | [
"DDInter139",
"DDInter1622"
] | Auranofin | Rosuvastatin | Auranofin is a gold salt that is capable of eliciting pharmacologic actions that suppress inflammation and stimulate cell-mediated immunity. It has subsequently been listed by the World Health Organization as a member of the antirheumatic agent category. Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA. Heme ox... | Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin... | Moderate | 1 | [
[
[
1112,
24,
14
]
],
[
[
1112,
6,
1829
],
[
1829,
45,
14
]
],
[
[
1112,
18,
11048
],
[
11048,
46,
14
]
],
[
[
1112,
18,
2900
],
[
2900,
... | [
[
[
"Auranofin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rosuvastatin"
]
],
[
[
"Auranofin",
"{u} (Compound) binds {v} (Gene)",
"ALB"
],
[
"ALB",
"{u} (Gene) is bound by {v} (Compound)",
... | Auranofin (Compound) binds ALB (Gene) and ALB (Gene) is bound by Rosuvastatin (Compound)
Auranofin (Compound) downregulates VAT1 (Gene) and VAT1 (Gene) is upregulated by Rosuvastatin (Compound)
Auranofin (Compound) downregulates NFKBIA (Gene) and NFKBIA (Gene) is downregulated by Rosuvastatin (Compound)
Auranofin (Comp... |
DB00059 | DB01048 | 1,560 | 764 | [
"DDInter1404",
"DDInter1"
] | Pegaspargase | Abacavir | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. Chemically, it is a synthetic carbocyclic nucleoside and is the enantiomer with 1S, 4R absolute configuration on the cyclopentene ring. In vivo, abacavir sulfate dissociates to its free base, abacavir. | Moderate | 1 | [
[
[
1560,
24,
764
]
],
[
[
1560,
24,
912
],
[
912,
24,
764
]
],
[
[
1560,
24,
1142
],
[
1142,
63,
764
]
],
[
[
1560,
25,
1510
],
[
1510,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abacavir"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Interferon beta-1a"
]... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Interferon beta-1a and Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Abacavir
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Orl... |
DB00490 | DB08820 | 946 | 1,478 | [
"DDInter254",
"DDInter997"
] | Buspirone | Ivacaftor | Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class, buspirone is a serotonin 5-HT<sub>1A</sub> receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic dr... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
946,
24,
1478
]
],
[
[
946,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
946,
21,
28762
],
[
28762,
60,
1478
]
],
[
[
946,
24,
1040
],
[
1040,... | [
[
[
"Buspirone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Buspirone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Buspirone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Buspirone (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Ivacaftor (Compound)
Buspirone may cause a moderate interaction that could exacerbate diseases when taken with Dabrafenib and Dabrafenib ... |
DB00722 | DB01088 | 743 | 714 | [
"DDInter1079",
"DDInter908"
] | Lisinopril | Iloprost | Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction.[L8384,L8387,L8390] Lisinopril and [captopril] are the only ACEIs that are not prodrugs. It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldos... | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Moderate | 1 | [
[
[
743,
24,
714
]
],
[
[
743,
40,
1638
],
[
1638,
24,
714
]
],
[
[
743,
24,
1479
],
[
1479,
24,
714
]
],
[
[
743,
63,
1648
],
[
1648,
... | [
[
[
"Lisinopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
]
],
[
[
"Lisinopril",
"{u} (Compound) resembles {v} (Compound)",
"Trandolapril"
],
[
"Trandolapril",
"{u} may cause a moder... | Lisinopril (Compound) resembles Trandolapril (Compound) and Trandolapril may cause a moderate interaction that could exacerbate diseases when taken with Iloprost
Lisinopril may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate ... |
DB00315 | DB01168 | 767 | 1,053 | [
"DDInter1969",
"DDInter1526"
] | Zolmitriptan | Procarbazine | Zolmitriptan is a member of the triptan class of 5-hydroxytryptamine(5-HT)<sub>1B/1D/(1F)</sub> receptor agonists used to treat acute migraine.[A462, L12978] [Sumatriptan] was the first triptan to be developed, but had poor oral bioavailability and lipophilicity. This led to the development of second-generation triptan... | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Major | 2 | [
[
[
767,
25,
1053
]
],
[
[
767,
21,
28762
],
[
28762,
60,
1053
]
],
[
[
767,
24,
1362
],
[
1362,
63,
1053
]
],
[
[
767,
25,
1039
],
[
1039... | [
[
[
"Zolmitriptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Procarbazine"
]
],
[
[
"Zolmitriptan",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is caused by {v} (... | Zolmitriptan (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Procarbazine (Compound)
Zolmitriptan may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Procarb... |
DB00563 | DB00951 | 663 | 1,072 | [
"DDInter1174",
"DDInter986"
] | Methotrexate | Isoniazid | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Moderate | 1 | [
[
[
663,
24,
1072
]
],
[
[
663,
21,
28722
],
[
28722,
60,
1072
]
],
[
[
663,
24,
1486
],
[
1486,
62,
1072
]
],
[
[
663,
24,
870
],
[
870,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoniazid"
]
],
[
[
"Methotrexate",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused ... | Methotrexate (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Isoniazid (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Methylprednisolone and Methylprednisolone may cause a minor interaction that can limit clinical effects when taken w... |
DB00701 | DB09272 | 1,091 | 412 | [
"DDInter90",
"DDInter632"
] | Amprenavir | Eluxadoline | Amprenavir is a protease inhibitor used to treat HIV infection. | Eluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D). The mu-, kappa-, and delta-opioid receptors mediate endogenous and exogenous opioid response in the central nervous system ... | Moderate | 1 | [
[
[
1091,
24,
412
]
],
[
[
1091,
25,
543
],
[
543,
24,
412
]
],
[
[
1091,
64,
467
],
[
467,
24,
412
]
],
[
[
1091,
23,
1374
],
[
1374,
... | [
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eluxadoline"
]
],
[
[
"Amprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Loperamide"
],
[
"Loperamid... | Amprenavir may lead to a major life threatening interaction when taken with Loperamide and Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Eluxadoline
Amprenavir may lead to a major life threatening interaction when taken with Simvastatin and Simvastatin may cause a moderate i... |
DB01098 | DB09115 | 14 | 505 | [
"DDInter1622",
"DDInter559"
] | Rosuvastatin | Diiodohydroxyquinoline | Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin... | Diiodohydroxyquinoline, also known as uidoquinol and iodoquinol, is a quinoline derivative that can be used in the treatment of amoebiasis. The exact mechanism of action is unknown. Iodoquinol is not currently available in any FDA-approved products. | Moderate | 1 | [
[
[
14,
24,
505
]
],
[
[
14,
24,
1593
],
[
1593,
24,
505
]
],
[
[
14,
63,
467
],
[
467,
24,
505
]
],
[
[
14,
25,
1510
],
[
1510,
24,... | [
[
[
"Rosuvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diiodohydroxyquinoline"
]
],
[
[
"Rosuvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"... | Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Diiodohydroxyquinoline
Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with Simva... |
DB00054 | DB01125 | 1,432 | 279 | [
"DDInter6",
"DDInter98"
] | Abciximab | Anisindione | Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (αv... | Anisindione is a synthetic anticoagulant and an indanedione derivative. Its anticoagulant action is mediated through the inhibition of the vitamin K-mediated gamma-carboxylation of precursor proteins that are critical in forming the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagu... | Major | 2 | [
[
[
1432,
25,
279
]
],
[
[
1432,
63,
1595
],
[
1595,
24,
279
]
],
[
[
1432,
24,
557
],
[
557,
63,
279
]
],
[
[
1432,
24,
222
],
[
222,
... | [
[
[
"Abciximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Anisindione"
]
],
[
[
"Abciximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Collagenase clostridium histolyticum"
]... | Abciximab may cause a moderate interaction that could exacerbate diseases when taken with Collagenase clostridium histolyticum and Collagenase clostridium histolyticum may cause a moderate interaction that could exacerbate diseases when taken with Anisindione
Abciximab may cause a moderate interaction that could exacer... |
DB00063 | DB14357 | 366 | 944 | [
"DDInter659",
"DDInter347"
] | Eptifibatide | Chamomile | Synthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation. Derived from venom of the Southeastern pygmy rattlesnake (Sistrurus miliarus barbouri), eptifibatide is a cyclic heptapeptide that belongs to the class of arginin-glycin-aspartat-mimetics. | Chamomile is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. | Minor | 0 | [
[
[
366,
23,
944
]
],
[
[
366,
25,
256
],
[
256,
23,
944
]
],
[
[
366,
64,
582
],
[
582,
23,
944
]
],
[
[
366,
24,
1061
],
[
1061,
2... | [
[
[
"Eptifibatide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
]
],
[
[
"Eptifibatide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prasugrel"
],
[
"Prasugrel"... | Eptifibatide may lead to a major life threatening interaction when taken with Prasugrel and Prasugrel may cause a minor interaction that can limit clinical effects when taken with Chamomile
Eptifibatide may lead to a major life threatening interaction when taken with Reteplase and Reteplase may cause a minor interactio... |
DB08903 | DB11110 | 996 | 603 | [
"DDInter170",
"DDInter1115"
] | Bedaquiline | Magnesium citrate | Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affe... | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
996,
24,
603
]
],
[
[
996,
64,
57
],
[
57,
24,
603
]
],
[
[
996,
25,
484
],
[
484,
63,
603
]
],
[
[
996,
25,
1228
],
[
1228,
24,... | [
[
[
"Bedaquiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Bedaquiline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
[
... | Bedaquiline may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Bedaquiline may lead to a major life threatening interaction when taken with Entrectinib and Entrectinib ma... |
DB05812 | DB08820 | 1,374 | 1,478 | [
"DDInter8",
"DDInter997"
] | Abiraterone | Ivacaftor | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
1374,
24,
1478
]
],
[
[
1374,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
1374,
21,
29221
],
[
29221,
60,
1478
]
],
[
[
1374,
23,
907
],
[
90... | [
[
[
"Abiraterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Abiraterone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Abiraterone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Abiraterone (Compound) causes Infestation (Side Effect) and Infestation (Side Effect) is caused by Ivacaftor (Compound)
Abiraterone may cause a minor interaction that can limit clinical effects when taken with Doravirine and D... |
DB01030 | DB08899 | 869 | 129 | [
"DDInter1835",
"DDInter649"
] | Topotecan | Enzalutamide | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
869,
24,
129
]
],
[
[
869,
6,
8374
],
[
8374,
45,
129
]
],
[
[
869,
21,
28703
],
[
28703,
60,
129
]
],
[
[
869,
24,
110
],
[
110,
... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Topotecan",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Topotecan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Topotecan (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Enzalutamide (Compound)
Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Polatuzumab vedotin ... |
DB06595 | DB08860 | 1,491 | 788 | [
"DDInter1214",
"DDInter1479"
] | Midostaurin | Pitavastatin | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the statin class of medications. By inhibiting the endogenous production of cholesterol within the liver, statins lower abnormal cholesterol and lipid levels and ultimately reduce the risk of cardiovascular disease. More sp... | Moderate | 1 | [
[
[
1491,
24,
788
]
],
[
[
1491,
63,
671
],
[
671,
1,
788
]
],
[
[
1491,
63,
700
],
[
700,
40,
788
]
],
[
[
1491,
24,
850
],
[
850,
... | [
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
]
],
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
],
... | Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin (Compound) resembles Pitavastatin (Compound)
Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Atorvastatin and Atorvastatin (Compound) resembles Pitavastatin... |
DB00022 | DB01004 | 268 | 563 | [
"DDInter1408",
"DDInter806"
] | Peginterferon alfa-2b | Ganciclovir | Peginterferon alfa-2b is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections. | Moderate | 1 | [
[
[
268,
24,
563
]
],
[
[
268,
24,
248
],
[
248,
40,
563
]
],
[
[
268,
24,
36
],
[
36,
63,
563
]
],
[
[
268,
25,
1101
],
[
1101,
24,... | [
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ganciclovir"
]
],
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valg... | Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Valganciclovir and Valganciclovir (Compound) resembles Ganciclovir (Compound)
Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Eribulin and Eribulin may cause a mode... |
DB00009 | DB00861 | 1,271 | 914 | [
"DDInter56",
"DDInter551"
] | Alteplase | Diflunisal | Alteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent. It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots. In the absence of fibrin, the alteplase-mediated conversion of plasminogen is limited, thanks to the high affinity between alteplas... | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | Moderate | 1 | [
[
[
1271,
24,
914
]
],
[
[
1271,
25,
1564
],
[
1564,
63,
914
]
],
[
[
1271,
24,
1061
],
[
1061,
24,
914
]
],
[
[
1271,
25,
366
],
[
366,
... | [
[
[
"Alteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diflunisal"
]
],
[
[
"Alteplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Defibrotide"
],
[
"Defibrotide... | Alteplase may lead to a major life threatening interaction when taken with Defibrotide and Defibrotide may cause a moderate interaction that could exacerbate diseases when taken with Diflunisal
Alteplase may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may ca... |
DB00008 | DB09115 | 491 | 505 | [
"DDInter1407",
"DDInter559"
] | Peginterferon alfa-2a | Diiodohydroxyquinoline | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Diiodohydroxyquinoline, also known as uidoquinol and iodoquinol, is a quinoline derivative that can be used in the treatment of amoebiasis. The exact mechanism of action is unknown. Iodoquinol is not currently available in any FDA-approved products. | Moderate | 1 | [
[
[
491,
24,
505
]
],
[
[
491,
24,
1593
],
[
1593,
24,
505
]
],
[
[
491,
25,
1510
],
[
1510,
24,
505
]
],
[
[
491,
24,
1434
],
[
1434,
... | [
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diiodohydroxyquinoline"
]
],
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Diiodohydroxyquinoline
Peginterferon alfa-2a may lead to a major life threatening interaction when taken with Te... |
DB00470 | DB00612 | 530 | 1,121 | [
"DDInter601",
"DDInter216"
] | Dronabinol | Bisoprolol | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | Moderate | 1 | [
[
[
530,
24,
1121
]
],
[
[
530,
24,
819
],
[
819,
40,
1121
]
],
[
[
530,
63,
88
],
[
88,
40,
1121
]
],
[
[
530,
6,
8374
],
[
8374,
4... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisoprolol"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acebutolol"
],
[
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Acebutolol and Acebutolol (Compound) resembles Bisoprolol (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Metoprolol and Metoprolol (Compound) resembles Bisoprolol (Compound)
... |
DB00860 | DB15699 | 891 | 652 | [
"DDInter1513",
"DDInter232"
] | Prednisolone | Brexucabtagene autoleucel | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Mantle cell lymphoma is a heterogeneous sub-category of non-Hodgkin's lymphoma that can be classified as either an aggressive nodal or an indolent leukemic non-nodal variant. Despite the introduction of Bruton's tyrosine kinase (BTK) inhibitors such as [ibrutinib] and [acalabrutinib], the prognosis for MCL patients rem... | Major | 2 | [
[
[
891,
25,
652
]
],
[
[
891,
24,
259
],
[
259,
24,
652
]
],
[
[
891,
63,
1184
],
[
1184,
24,
652
]
],
[
[
891,
25,
976
],
[
976,
2... | [
[
[
"Prednisolone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brexucabtagene autoleucel"
]
],
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
],
... | Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Brexucabtagene autoleucel
Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with An... |
DB06210 | DB09061 | 72 | 1,627 | [
"DDInter631",
"DDInter284"
] | Eltrombopag | Cannabidiol | Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelet... | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
72,
24,
1627
]
],
[
[
72,
24,
384
],
[
384,
23,
1627
]
],
[
[
72,
24,
351
],
[
351,
62,
1627
]
],
[
[
72,
63,
1419
],
[
1419,
23... | [
[
[
"Eltrombopag",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Eltrombopag",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
[... | Eltrombopag may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a minor interaction that can limit clinical effects when taken with Cannabidiol
Eltrombopag may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Riboc... |
DB00365 | DB06699 | 839 | 774 | [
"DDInter842",
"DDInter493"
] | Grepafloxacin | Degarelix | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Major | 2 | [
[
[
839,
25,
774
]
],
[
[
839,
64,
521
],
[
521,
1,
774
]
],
[
[
839,
23,
112
],
[
112,
23,
774
]
],
[
[
839,
25,
888
],
[
888,
24,
... | [
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Degarelix"
]
],
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Goserelin"
],
[
"Goserelin",
"{u... | Grepafloxacin may lead to a major life threatening interaction when taken with Goserelin and Goserelin (Compound) resembles Degarelix (Compound)
Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinic... |
DB00046 | DB00252 | 1,179 | 362 | [
"DDInter940",
"DDInter1460"
] | Insulin lispro | Phenytoin | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Moderate | 1 | [
[
[
1179,
24,
362
]
],
[
[
1179,
24,
651
],
[
651,
40,
362
]
],
[
[
1179,
24,
1101
],
[
1101,
62,
362
]
],
[
[
1179,
24,
167
],
[
167,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
],... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Fosphenytoin and Fosphenytoin (Compound) resembles Phenytoin (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction th... |
DB10343 | DB12267 | 962 | 1,476 | [
"DDInter160",
"DDInter233"
] | Bacillus calmette-guerin substrain tice live antigen | Brigatinib | Bacillus calmette-guerin substrain tice live antigen is a vaccine containing attenuated live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of *Mycobacterium bovis* for percutaneous use. It is administered to prevent the development of tuberculosis. | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Major | 2 | [
[
[
962,
25,
1476
]
],
[
[
962,
64,
168
],
[
168,
23,
1476
]
],
[
[
962,
64,
629
],
[
629,
24,
1476
]
],
[
[
962,
25,
1456
],
[
1456,
... | [
[
[
"Bacillus calmette-guerin substrain tice live antigen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brigatinib"
]
],
[
[
"Bacillus calmette-guerin substrain tice live antigen",
"{u} may lead to a major life threatening interaction wh... | Bacillus calmette-guerin substrain tice live antigen may lead to a major life threatening interaction when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Bacillus calmette-guerin substrain tice live antigen may lead to a major life threateni... |
DB00059 | DB00559 | 1,560 | 152 | [
"DDInter1404",
"DDInter223"
] | Pegaspargase | Bosentan | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure. | Moderate | 1 | [
[
[
1560,
24,
152
]
],
[
[
1560,
24,
168
],
[
168,
23,
152
]
],
[
[
1560,
25,
1101
],
[
1101,
23,
152
]
],
[
[
1560,
24,
1613
],
[
1613,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosentan"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Bosentan
Pegaspargase may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause ... |
DB00907 | DB09241 | 290 | 1,629 | [
"DDInter427",
"DDInter1186"
] | Cocaine (topical) | Methylene blue | Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts. | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Major | 2 | [
[
[
290,
25,
1629
]
],
[
[
290,
64,
1052
],
[
1052,
24,
1629
]
],
[
[
290,
25,
1148
],
[
1148,
24,
1629
]
],
[
[
290,
24,
697
],
[
697,
... | [
[
[
"Cocaine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylene blue"
]
],
[
[
"Cocaine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ritodrine"
],
[
"Ritodrine",
"{u} may c... | Cocaine may lead to a major life threatening interaction when taken with Methylene blue
Cocaine may lead to a major life threatening interaction when taken with Ritodrine and Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Cocaine may lead to a major life threate... |
DB01404 | DB09030 | 757 | 840 | [
"DDInter820",
"DDInter1945"
] | Ginseng | Vorapaxar | Ginseng is promoted as an adaptogen (a product that increases the body's resistance to stress), one which can to a certain extent be supported with reference to its anticarcinogenic and antioxidant properties. Ginseng is also known to contain phytoestrogens. | Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expr... | Moderate | 1 | [
[
[
757,
24,
840
]
],
[
[
757,
24,
578
],
[
578,
24,
840
]
],
[
[
757,
63,
500
],
[
500,
25,
840
]
],
[
[
757,
24,
1409
],
[
1409,
2... | [
[
[
"Ginseng",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vorapaxar"
]
],
[
[
"Ginseng",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
],
[
"Ti... | Ginseng may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Vorapaxar
Ginseng may cause a moderate interaction that could exacerbate diseases when taken with Enoxaparin and Enoxaparin ma... |
DB00771 | DB06077 | 262 | 879 | [
"DDInter397",
"DDInter1102"
] | Clidinium | Lumateperone | Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. It inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. It is used for the tr... | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Moderate | 1 | [
[
[
262,
24,
879
]
],
[
[
262,
24,
407
],
[
407,
63,
879
]
],
[
[
262,
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1511
],
[
1511,
24,
879
]
],
[
[
262,
63,
999
],
[
999,
2... | [
[
[
"Clidinium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lumateperone"
]
],
[
[
"Clidinium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
],
[
"... | Clidinium may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause a moderate interaction that could exacerbate diseases when taken with Lumateperone
Clidinium may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may... |
DB00934 | DB08899 | 413 | 129 | [
"DDInter1124",
"DDInter649"
] | Maprotiline | Enzalutamide | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
413,
24,
129
]
],
[
[
413,
24,
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[
918,
1,
129
]
],
[
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413,
6,
12523
],
[
12523,
45,
129
]
],
[
[
413,
21,
28703
],
[
28703,
... | [
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
],
... | Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Maprotiline (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Enzalutamide (Compound)
Maprotiline (Compound) causes Pruritus (Side Effect) and... |
DB10316 | DB12498 | 334 | 76 | [
"DDInter1248",
"DDInter1238"
] | Mumps virus strain B level jeryl lynn live antigen | Mogamulizumab | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Mogamulizumab is a humanized monoclonal antibody (mAb) directed against CC chemokine receptor 4 (CCR4) for the treatment of Mycosis Fungoides (MF) and Sézary Syndrome (SS), the most common subtypes of cutaneous T-cell lymphoma. Cutaneous T-cell lymphomas occur when certain white blood cells, called T cells, become canc... | Major | 2 | [
[
[
334,
25,
76
]
],
[
[
334,
64,
1531
],
[
1531,
24,
76
]
],
[
[
334,
25,
738
],
[
738,
24,
76
]
],
[
[
334,
25,
676
],
[
676,
64,
... | [
[
[
"Mumps virus strain B level jeryl lynn live antigen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mogamulizumab"
]
],
[
[
"Mumps virus strain B level jeryl lynn live antigen",
"{u} may lead to a major life threatening interaction whe... | Mumps virus strain B level jeryl lynn live antigen may lead to a major life threatening interaction when taken with Canakinumab and Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Mogamulizumab
Mumps virus strain B level jeryl lynn live antigen may lead to a major life threat... |
DB01244 | DB01254 | 762 | 1,213 | [
"DDInter192",
"DDInter484"
] | Bepridil | Dasatinib | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Major | 2 | [
[
[
762,
25,
1213
]
],
[
[
762,
6,
4973
],
[
4973,
45,
1213
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],
[
[
762,
21,
28882
],
[
28882,
60,
1213
]
],
[
[
762,
62,
112
],
[
112,
... | [
[
[
"Bepridil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
]
],
[
[
"Bepridil",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Dasatinib"
... | Bepridil (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dasatinib (Compound)
Bepridil (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Dasatinib (Compound)
Bepridil may cause a minor interaction that can limit clinical effects when taken wi... |
DB00059 | DB09122 | 1,560 | 1,613 | [
"DDInter1404",
"DDInter1409"
] | Pegaspargase | Peginterferon beta-1a | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
1560,
24,
1613
]
],
[
[
1560,
24,
671
],
[
671,
24,
1613
]
],
[
[
1560,
24,
975
],
[
975,
63,
1613
]
],
[
[
1560,
63,
816
],
[
816,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Lurb... |
DB00446 | DB01005 | 597 | 995 | [
"DDInter351",
"DDInter894"
] | Chloramphenicol | Hydroxyurea | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, h... | Moderate | 1 | [
[
[
597,
24,
995
]
],
[
[
597,
21,
28883
],
[
28883,
60,
995
]
],
[
[
597,
24,
1238
],
[
1238,
24,
995
]
],
[
[
597,
24,
869
],
[
869,
... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyurea"
]
],
[
[
"Chloramphenicol",
"{u} (Compound) causes {v} (Side Effect)",
"Skin disorder"
],
[
"Skin disorder",
"{u} (S... | Chloramphenicol (Compound) causes Skin disorder (Side Effect) and Skin disorder (Side Effect) is caused by Hydroxyurea (Compound)
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Pentostatin and Pentostatin may cause a moderate interaction that could exacerbate diseases wh... |
DB00850 | DB11130 | 1,630 | 407 | [
"DDInter1432",
"DDInter1344"
] | Perphenazine | Opium | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
1630,
24,
407
]
],
[
[
1630,
63,
662
],
[
662,
24,
407
]
],
[
[
1630,
35,
104
],
[
104,
24,
407
]
],
[
[
1630,
24,
849
],
[
849,
... | [
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
[
... | Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Perphenazine (Compound) resembles Methdilazine (Compound) and Perphenazine may cause a moderate interaction t... |
DB06605 | DB08896 | 1,409 | 292 | [
"DDInter108",
"DDInter1576"
] | Apixaban | Regorafenib | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Major | 2 | [
[
[
1409,
25,
292
]
],
[
[
1409,
63,
79
],
[
79,
1,
292
]
],
[
[
1409,
6,
6017
],
[
6017,
45,
292
]
],
[
[
1409,
21,
29122
],
[
29122,
... | [
[
[
"Apixaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Regorafenib"
]
],
[
[
"Apixaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sorafenib"
],
[
"Sorafenib",
... | Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib (Compound) resembles Regorafenib (Compound)
Apixaban (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Regorafenib (Compound)
Apixaban (Compound) causes Mediastinal disorder (Side Effect) and Medi... |
DB00757 | DB08903 | 1,166 | 996 | [
"DDInter581",
"DDInter170"
] | Dolasetron | Bedaquiline | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affe... | Major | 2 | [
[
[
1166,
25,
996
]
],
[
[
1166,
6,
8374
],
[
8374,
45,
996
]
],
[
[
1166,
21,
29282
],
[
29282,
60,
996
]
],
[
[
1166,
23,
112
],
[
112,
... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bedaquiline"
]
],
[
[
"Dolasetron",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Bedaqu... | Dolasetron (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bedaquiline (Compound)
Dolasetron (Compound) causes Arrhythmia (Side Effect) and Arrhythmia (Side Effect) is caused by Bedaquiline (Compound)
Dolasetron may cause a minor interaction that can limit clinical effects when taken with Metronidazole and... |
DB00445 | DB00740 | 322 | 424 | [
"DDInter655",
"DDInter1596"
] | Epirubicin | Riluzole | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | A glutamate antagonist (receptors, glutamate) used as an anticonvulsant (anticonvulsants) and to prolong the survival of patients with amyotrophic lateral sclerosis. Riluzole is marketed as Rilutek by Sanofi. | Moderate | 1 | [
[
[
322,
24,
424
]
],
[
[
322,
7,
2602
],
[
2602,
46,
424
]
],
[
[
322,
7,
19748
],
[
19748,
57,
424
]
],
[
[
322,
18,
8914
],
[
8914,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Riluzole"
]
],
[
[
"Epirubicin",
"{u} (Compound) upregulates {v} (Gene)",
"PTK2B"
],
[
"PTK2B",
"{u} (Gene) is upregulated by {v} (Com... | Epirubicin (Compound) upregulates PTK2B (Gene) and PTK2B (Gene) is upregulated by Riluzole (Compound)
Epirubicin (Compound) upregulates PRAF2 (Gene) and PRAF2 (Gene) is downregulated by Riluzole (Compound)
Epirubicin (Compound) downregulates NUP85 (Gene) and NUP85 (Gene) is downregulated by Riluzole (Compound)
Epirubic... |
DB00400 | DB06414 | 353 | 655 | [
"DDInter843",
"DDInter703"
] | Griseofulvin | Etravirine | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Moderate | 1 | [
[
[
353,
24,
655
]
],
[
[
353,
24,
786
],
[
786,
40,
655
]
],
[
[
353,
6,
8374
],
[
8374,
45,
655
]
],
[
[
353,
21,
28680
],
[
28680,
... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
]
],
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilpivirine"
],
... | Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Rilpivirine and Rilpivirine (Compound) resembles Etravirine (Compound)
Griseofulvin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Etravirine (Compound)
Griseofulvin (Compound) causes Rash (Side Effect) and Rash (... |
DB00655 | DB01254 | 559 | 1,213 | [
"DDInter682",
"DDInter484"
] | Estrone | Dasatinib | Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
559,
24,
1213
]
],
[
[
559,
6,
17404
],
[
17404,
45,
1213
]
],
[
[
559,
18,
10375
],
[
10375,
57,
1213
]
],
[
[
559,
21,
28845
],
[
28... | [
[
[
"Estrone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Estrone",
"{u} (Compound) binds {v} (Gene)",
"ABCG2"
],
[
"ABCG2",
"{u} (Gene) is bound by {v} (Compound)",
"D... | Estrone (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Dasatinib (Compound)
Estrone (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Dasatinib (Compound)
Estrone (Compound) causes Oedema (Side Effect) and Oedema (Side Effect) is caused by Dasatinib (Compound)
Estrone may cause a ... |
DB01035 | DB01128 | 1,401 | 918 | [
"DDInter1524",
"DDInter204"
] | Procainamide | Bicalutamide | A derivative of procaine with less CNS action. | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Major | 2 | [
[
[
1401,
25,
918
]
],
[
[
1401,
25,
129
],
[
129,
40,
918
]
],
[
[
1401,
6,
12523
],
[
12523,
45,
918
]
],
[
[
1401,
21,
28642
],
[
28642... | [
[
[
"Procainamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bicalutamide"
]
],
[
[
"Procainamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
],
[
"Enzalutamide",
... | Procainamide may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide (Compound) resembles Bicalutamide (Compound)
Procainamide (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Bicalutamide (Compound)
Procainamide (Compound) causes Shock (Side Effect) and Shock (Side Ef... |
DB01211 | DB15035 | 609 | 503 | [
"DDInter393",
"DDInter1959"
] | Clarithromycin | Zanubrutinib | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Major | 2 | [
[
[
609,
25,
503
]
],
[
[
609,
25,
982
],
[
982,
24,
503
]
],
[
[
609,
62,
222
],
[
222,
24,
503
]
],
[
[
609,
63,
1324
],
[
1324,
2... | [
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
],
[
"Ivosidenib",
... | Clarithromycin may lead to a major life threatening interaction when taken with Ivosidenib and Ivosidenib may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Sibutramine and Sibutramine ... |
DB00635 | DB00876 | 1,573 | 1,414 | [
"DDInter1515",
"DDInter658"
] | Prednisone | Eprosartan | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Eprosartan is an angiotensin II receptor antagonist used to treat hypertension. It performs 2 actions on the renin angiotensin system. By preventing the binding of angiotensin II to AT1, vascular smooth muscle relaxes and vasodilation occurs. By inhibiting norepinephrine production, blood pressure is further reduced. | Moderate | 1 | [
[
[
1573,
24,
1414
]
],
[
[
1573,
24,
240
],
[
240,
40,
1414
]
],
[
[
1573,
21,
28957
],
[
28957,
60,
1414
]
],
[
[
1573,
63,
176
],
[
176... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eprosartan"
]
],
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Losartan"
],
[
... | Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Losartan and Losartan (Compound) resembles Eprosartan (Compound)
Prednisone (Compound) causes Arthralgia (Side Effect) and Arthralgia (Side Effect) is caused by Eprosartan (Compound)
Prednisone may cause a moderate interaction th... |
DB00816 | DB01177 | 1,674 | 77 | [
"DDInter1346",
"DDInter904"
] | Orciprenaline | Idarubicin | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Moderate | 1 | [
[
[
1674,
24,
77
]
],
[
[
1674,
7,
1917
],
[
1917,
57,
77
]
],
[
[
1674,
21,
28987
],
[
28987,
60,
77
]
],
[
[
1674,
24,
739
],
[
739,
... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idarubicin"
]
],
[
[
"Orciprenaline",
"{u} (Compound) upregulates {v} (Gene)",
"CDC25B"
],
[
"CDC25B",
"{u} (Gene) is downregulated... | Orciprenaline (Compound) upregulates CDC25B (Gene) and CDC25B (Gene) is downregulated by Idarubicin (Compound)
Orciprenaline (Compound) causes Chills (Side Effect) and Chills (Side Effect) is caused by Idarubicin (Compound)
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Lo... |
DB00289 | DB08865 | 847 | 1,593 | [
"DDInter132",
"DDInter448"
] | Atomoxetine | Crizotinib | Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD). Also known as the marketed product Strattera, atomoxetine is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve develop... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Major | 2 | [
[
[
847,
25,
1593
]
],
[
[
847,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
847,
18,
1903
],
[
1903,
57,
1593
]
],
[
[
847,
21,
29093
],
[
29093,... | [
[
[
"Atomoxetine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
]
],
[
[
"Atomoxetine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Crizo... | Atomoxetine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Atomoxetine (Compound) downregulates FABP5 (Gene) and FABP5 (Gene) is downregulated by Crizotinib (Compound)
Atomoxetine (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Crizotinib (Compound)
Ato... |
DB00978 | DB01268 | 739 | 1,151 | [
"DDInter1084",
"DDInter1731"
] | Lomefloxacin | Sunitinib | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Moderate | 1 | [
[
[
739,
24,
1151
]
],
[
[
739,
6,
5912
],
[
5912,
45,
1151
]
],
[
[
739,
21,
29662
],
[
29662,
60,
1151
]
],
[
[
739,
62,
112
],
[
112,
... | [
[
[
"Lomefloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
]
],
[
[
"Lomefloxacin",
"{u} (Compound) binds {v} (Gene)",
"ABCC2"
],
[
"ABCC2",
"{u} (Gene) is bound by {v} (Compound)"... | Lomefloxacin (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Sunitinib (Compound)
Lomefloxacin (Compound) causes Candida infection (Side Effect) and Candida infection (Side Effect) is caused by Sunitinib (Compound)
Lomefloxacin may cause a minor interaction that can limit clinical effects when taken with Met... |
DB01142 | DB15982 | 1,264 | 1,339 | [
"DDInter593",
"DDInter193"
] | Doxepin | Berotralstat | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat ... | Moderate | 1 | [
[
[
1264,
24,
1339
]
],
[
[
1264,
64,
222
],
[
222,
23,
1339
]
],
[
[
1264,
24,
283
],
[
283,
23,
1339
]
],
[
[
1264,
24,
1213
],
[
1213,
... | [
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Berotralstat"
]
],
[
[
"Doxepin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
],
[
"Sibutramine",... | Doxepin may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Berotralstat
Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a mi... |
DB00041 | DB08904 | 1,648 | 375 | [
"DDInter38",
"DDInter342"
] | Aldesleukin | Certolizumab pegol | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Major | 2 | [
[
[
1648,
25,
375
]
],
[
[
1648,
24,
704
],
[
704,
24,
375
]
],
[
[
1648,
24,
200
],
[
200,
63,
375
]
],
[
[
1648,
25,
367
],
[
367,
... | [
[
[
"Aldesleukin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fentanyl"
],
[
"Fe... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl may cause a moderate interaction that could exacerbate diseases when taken with Certolizumab pegol
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Candida albican... |
DB00398 | DB06402 | 79 | 1,079 | [
"DDInter1702",
"DDInter1756"
] | Sorafenib | Telavancin | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria. MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and skin and sub... | Moderate | 1 | [
[
[
79,
24,
1079
]
],
[
[
79,
24,
968
],
[
968,
40,
1079
]
],
[
[
79,
21,
28750
],
[
28750,
60,
1079
]
],
[
[
79,
23,
112
],
[
112,
... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telavancin"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oritavancin"
],
[
... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Oritavancin and Oritavancin (Compound) resembles Telavancin (Compound)
Sorafenib (Compound) causes Abdominal discomfort (Side Effect) and Abdominal discomfort (Side Effect) is caused by Telavancin (Compound)
Sorafenib may cause a ... |
DB00976 | DB05812 | 1,056 | 1,374 | [
"DDInter1758",
"DDInter8"
] | Telithromycin | Abiraterone | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
1056,
24,
1374
]
],
[
[
1056,
6,
12523
],
[
12523,
45,
1374
]
],
[
[
1056,
21,
29113
],
[
29113,
60,
1374
]
],
[
[
1056,
24,
466
],
[
... | [
[
[
"Telithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Telithromycin",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Comp... | Telithromycin (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Abiraterone (Compound)
Telithromycin (Compound) causes Hypokalaemia (Side Effect) and Hypokalaemia (Side Effect) is caused by Abiraterone (Compound)
Telithromycin may cause a moderate interaction that could exacerbate diseases when taken with Da... |
DB00367 | DB00414 | 566 | 590 | [
"DDInter1061",
"DDInter16"
] | Levonorgestrel | Acetohexamide | Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of ... | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Moderate | 1 | [
[
[
566,
24,
590
]
],
[
[
566,
24,
1017
],
[
1017,
63,
590
]
],
[
[
566,
40,
989
],
[
989,
24,
590
]
],
[
[
566,
40,
1197
],
[
1197,
... | [
[
[
"Levonorgestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetohexamide"
]
],
[
[
"Levonorgestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
... | Levonorgestrel may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide
Levonorgestrel (Compound) resembles Progesterone (Compound) and Progesterone may cause a moderate interac... |
DB00697 | DB01259 | 876 | 392 | [
"DDInter1821",
"DDInter1024"
] | Tizanidine | Lapatinib | Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury. It may also be caused by musculoskeletal injury. Regardless of the cause, muscle spasticity can be an extremely painful and debili... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
876,
24,
392
]
],
[
[
876,
18,
10780
],
[
10780,
46,
392
]
],
[
[
876,
21,
29539
],
[
29539,
60,
392
]
],
[
[
876,
23,
112
],
[
112,
... | [
[
[
"Tizanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Tizanidine",
"{u} (Compound) downregulates {v} (Gene)",
"CCNB2"
],
[
"CCNB2",
"{u} (Gene) is upregulated by {v} (... | Tizanidine (Compound) downregulates CCNB2 (Gene) and CCNB2 (Gene) is upregulated by Lapatinib (Compound)
Tizanidine (Compound) causes Hepatotoxicity (Side Effect) and Hepatotoxicity (Side Effect) is caused by Lapatinib (Compound)
Tizanidine may cause a minor interaction that can limit clinical effects when taken with M... |
DB01045 | DB11837 | 463 | 1,297 | [
"DDInter1590",
"DDInter1351"
] | Rifampicin | Osilodrostat | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Major | 2 | [
[
[
463,
25,
1297
]
],
[
[
463,
25,
1135
],
[
1135,
23,
1297
]
],
[
[
463,
63,
112
],
[
112,
23,
1297
]
],
[
[
463,
25,
466
],
[
466,
... | [
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osilodrostat"
]
],
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} m... | Rifampicin may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Rifampicin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may ca... |
DB09272 | DB11130 | 412 | 407 | [
"DDInter632",
"DDInter1344"
] | Eluxadoline | Opium | Eluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D). The mu-, kappa-, and delta-opioid receptors mediate endogenous and exogenous opioid response in the central nervous system ... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
412,
24,
407
]
],
[
[
412,
63,
662
],
[
662,
24,
407
]
],
[
[
412,
24,
1536
],
[
1536,
63,
407
]
],
[
[
412,
63,
314
],
[
314,
2... | [
[
[
"Eluxadoline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Eluxadoline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
[
... | Eluxadoline may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Eluxadoline may cause a moderate interaction that could exacerbate diseases when taken with Belladonna and Bel... |
DB06589 | DB08827 | 1,250 | 990 | [
"DDInter1400",
"DDInter1085"
] | Pazopanib | Lomitapide | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Major | 2 | [
[
[
1250,
25,
990
]
],
[
[
1250,
64,
1080
],
[
1080,
1,
990
]
],
[
[
1250,
6,
8374
],
[
8374,
45,
990
]
],
[
[
1250,
54,
19146
],
[
19146,... | [
[
[
"Pazopanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomitapide"
]
],
[
[
"Pazopanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Conivaptan"
],
[
"Conivaptan",
"{u} (Co... | Pazopanib may lead to a major life threatening interaction when taken with Conivaptan and Conivaptan (Compound) resembles Lomitapide (Compound)
Pazopanib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lomitapide (Compound)
Pazopanib (Compound) is included by Cytochrome P450 3A4 Inhibitors (Pharmacologic C... |
DB00651 | DB00683 | 746 | 1,382 | [
"DDInter613",
"DDInter1212"
] | Dyphylline | Midazolam | Dyphylline is a theophylline derivative with broncho- and vasodilator properties. It is typically used in the management of asthma, cardiac dyspnea, and bronchitis. | Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called _benzodiazepines_. This drug is unique from others in this class due to its rapid onset of effects and short duration of action. Midazola... | Minor | 0 | [
[
[
746,
23,
1382
]
],
[
[
746,
23,
1216
],
[
1216,
40,
1382
]
],
[
[
746,
62,
902
],
[
902,
40,
1382
]
],
[
[
746,
21,
28762
],
[
28762,
... | [
[
[
"Dyphylline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Midazolam"
]
],
[
[
"Dyphylline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Flurazepam"
],
[
"... | Dyphylline may cause a minor interaction that can limit clinical effects when taken with Flurazepam and Flurazepam (Compound) resembles Midazolam (Compound)
Dyphylline may cause a minor interaction that can limit clinical effects when taken with Clobazam and Clobazam (Compound) resembles Midazolam (Compound)
Dyphylline... |
DB08896 | DB15035 | 292 | 503 | [
"DDInter1576",
"DDInter1959"
] | Regorafenib | Zanubrutinib | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Major | 2 | [
[
[
292,
25,
503
]
],
[
[
292,
63,
222
],
[
222,
24,
503
]
],
[
[
292,
24,
98
],
[
98,
24,
503
]
],
[
[
292,
64,
39
],
[
39,
25,
... | [
[
[
"Regorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Regorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"Sibut... | Regorafenib may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Regorafenib may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and So... |
DB00584 | DB01069 | 610 | 401 | [
"DDInter638",
"DDInter1533"
] | Enalapril | Promethazine | Enalapril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor drug class that works on the renin-angiotensin-aldosterone system, which is responsible for the regulation of blood pressure and fluid and electrolyte homeostasis. Enalapril is an orally-active and long-acting nonsulphydryl antihypert... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
610,
24,
401
]
],
[
[
610,
24,
1264
],
[
1264,
63,
401
]
],
[
[
610,
24,
104
],
[
104,
24,
401
]
],
[
[
610,
6,
4973
],
[
4973,
... | [
[
[
"Enalapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Enalapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Enalapril may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Enalapril may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazi... |
DB00277 | DB00357 | 1,031 | 1,051 | [
"DDInter1791",
"DDInter71"
] | Theophylline | Aminoglutethimide | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Moderate | 1 | [
[
[
1031,
24,
1051
]
],
[
[
1031,
6,
8374
],
[
8374,
45,
1051
]
],
[
[
1031,
21,
28681
],
[
28681,
60,
1051
]
],
[
[
1031,
24,
1056
],
[
1... | [
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aminoglutethimide"
]
],
[
[
"Theophylline",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (... | Theophylline (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Aminoglutethimide (Compound)
Theophylline (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Aminoglutethimide (Compound)
Theophylline may cause a moderate interaction that could exacerbate diseases w... |
DB00559 | DB06603 | 152 | 39 | [
"DDInter223",
"DDInter1387"
] | Bosentan | Panobinostat | Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure. | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Moderate | 1 | [
[
[
152,
24,
39
]
],
[
[
152,
24,
112
],
[
112,
23,
39
]
],
[
[
152,
63,
912
],
[
912,
24,
39
]
],
[
[
152,
24,
578
],
[
578,
63,
... | [
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Panobinostat"
]
],
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Bosentan may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Bosentan may cause a moderate interaction that could exacerbate diseases when taken with Interferon beta-1a ... |
DB00863 | DB01066 | 1,194 | 1,462 | [
"DDInter1568",
"DDInter316"
] | Ranitidine | Cefditoren | Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as [cimetidine] and [famotidine]. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.[A176759,L10818]... | Cefditoren is an oral third-generation cephalosporin. It is commonly marketed under the trade name Spectracef by Cornerstone BioPharma. | Moderate | 1 | [
[
[
1194,
24,
1462
]
],
[
[
1194,
24,
665
],
[
665,
40,
1462
]
],
[
[
1194,
23,
115
],
[
115,
63,
1462
]
],
[
[
1194,
63,
126
],
[
126,
... | [
[
[
"Ranitidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefditoren"
]
],
[
[
"Ranitidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefuroxime"
],
[
... | Ranitidine may cause a moderate interaction that could exacerbate diseases when taken with Cefuroxime and Cefuroxime (Compound) resembles Cefditoren (Compound)
Ranitidine may cause a minor interaction that can limit clinical effects when taken with Aluminum hydroxide and Aluminum hydroxide may cause a moderate interact... |
DB00792 | DB06700 | 832 | 643 | [
"DDInter1878",
"DDInter511"
] | Tripelennamine | Desvenlafaxine | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of ad... | Moderate | 1 | [
[
[
832,
24,
643
]
],
[
[
832,
63,
1100
],
[
1100,
1,
643
]
],
[
[
832,
24,
1311
],
[
1311,
24,
643
]
],
[
[
832,
63,
530
],
[
530,
... | [
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desvenlafaxine"
]
],
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venlafaxine"
... | Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine (Compound) resembles Desvenlafaxine (Compound)
Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide may cause a moderate ... |
DB01246 | DB01591 | 820 | 667 | [
"DDInter45",
"DDInter1696"
] | Alimemazine | Solifenacin | A phenothiazine derivative that is used as an antipruritic. | Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004. | Moderate | 1 | [
[
[
820,
24,
667
]
],
[
[
820,
40,
11220
],
[
11220,
1,
667
]
],
[
[
820,
6,
8374
],
[
8374,
45,
667
]
],
[
[
820,
21,
28643
],
[
28643,
... | [
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Solifenacin"
]
],
[
[
"Alimemazine",
"{u} (Compound) resembles {v} (Compound)",
"Mequitazine"
],
[
"Mequitazine",
"{u} (Compound) res... | Alimemazine (Compound) resembles Mequitazine (Compound) and Mequitazine (Compound) resembles Solifenacin (Compound)
Alimemazine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Solifenacin (Compound)
Alimemazine (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Solifenacin (... |
DB00377 | DB06589 | 1,494 | 1,250 | [
"DDInter1382",
"DDInter1400"
] | Palonosetron | Pazopanib | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
1494,
24,
1250
]
],
[
[
1494,
6,
7950
],
[
7950,
45,
1250
]
],
[
[
1494,
21,
29203
],
[
29203,
60,
1250
]
],
[
[
1494,
23,
1247
],
[
1... | [
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Palonosetron",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound... | Palonosetron (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Pazopanib (Compound)
Palonosetron (Compound) causes Aspartate aminotransferase increased (Side Effect) and Aspartate aminotransferase increased (Side Effect) is caused by Pazopanib (Compound)
Palonosetron may cause a minor interaction that can li... |
DB00692 | DB01246 | 274 | 820 | [
"DDInter1448",
"DDInter45"
] | Phentolamine | Alimemazine | Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
274,
24,
820
]
],
[
[
274,
24,
358
],
[
358,
24,
820
]
],
[
[
274,
24,
104
],
[
104,
40,
820
]
],
[
[
274,
63,
675
],
[
675,
25,... | [
[
[
"Phentolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Phentolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orphenadrine"
],
... | Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine... |
DB00683 | DB04868 | 1,382 | 478 | [
"DDInter1212",
"DDInter1293"
] | Midazolam | Nilotinib | Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called _benzodiazepines_. This drug is unique from others in this class due to its rapid onset of effects and short duration of action. Midazola... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Moderate | 1 | [
[
[
1382,
24,
478
]
],
[
[
1382,
6,
4973
],
[
4973,
45,
478
]
],
[
[
1382,
21,
28963
],
[
28963,
60,
478
]
],
[
[
1382,
24,
1040
],
[
1040... | [
[
[
"Midazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]
],
[
[
"Midazolam",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Midazolam (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Nilotinib (Compound)
Midazolam (Compound) causes Anxiety (Side Effect) and Anxiety (Side Effect) is caused by Nilotinib (Compound)
Midazolam may cause a moderate interaction that could exacerbate diseases when taken with Dabrafenib and Dabrafenib may ... |
DB01181 | DB01206 | 1,532 | 37 | [
"DDInter906",
"DDInter1086"
] | Ifosfamide | Lomustine | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | An alkylating agent of value against both hematologic malignancies and solid tumors. | Moderate | 1 | [
[
[
1532,
24,
37
]
],
[
[
1532,
5,
11555
],
[
11555,
44,
37
]
],
[
[
1532,
6,
8374
],
[
8374,
45,
37
]
],
[
[
1532,
54,
19138
],
[
19138,
... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomustine"
]
],
[
[
"Ifosfamide",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease... | Ifosfamide (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Lomustine (Compound)
Ifosfamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lomustine (Compound)
Ifosfamide (Compound) is included by Alkylating Activity (Pharmacologic Class) and Alkylating Activit... |
DB00807 | DB06608 | 1,120 | 1,185 | [
"DDInter1536",
"DDInter1739"
] | Proparacaine (ophthalmic) | Tafenoquine | Proparacaine is a benzoate ester. | Tafenoquine is an 8-aminoquinoline analogue of primaquine which varies only on the presence of a 5-phenoxy group.[A35671, A35690] It was discovered by the scientists at the Walter Reed Army Institute of Research in 1978 as a substitute for primaquine that would be more effective against relapsing vivax malaria. Tafenoq... | Moderate | 1 | [
[
[
1120,
24,
1185
]
],
[
[
1120,
24,
1520
],
[
1520,
63,
10
],
[
10,
24,
1185
]
],
[
[
1120,
1,
33
],
[
33,
63,
10
],
[
10,
24,
1... | [
[
[
"Proparacaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tafenoquine"
]
],
[
[
"Proparacaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
],
... | Proparacaine may cause a moderate interaction that could exacerbate diseases when taken with Tafenoquine
Proparacaine may cause a moderate interaction that could exacerbate diseases when taken with Primaquine and Primaquine may cause a moderate interaction that could exacerbate diseases when taken with Dapsone and Daps... |
DB00284 | DB01284 | 1,647 | 1,042 | [
"DDInter11",
"DDInter1782"
] | Acarbose | Tetracosactide | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Moderate | 1 | [
[
[
1647,
24,
1042
]
],
[
[
1647,
24,
455
],
[
455,
23,
1042
]
],
[
[
1647,
24,
659
],
[
659,
62,
1042
]
],
[
[
1647,
24,
811
],
[
811,
... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
]
],
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
],
[
... | Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a minor interaction that can limit clinical effects when taken with Tetracosactide
Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilanter... |
DB00549 | DB01166 | 522 | 477 | [
"DDInter1955",
"DDInter379"
] | Zafirlukast | Cilostazol | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Moderate | 1 | [
[
[
522,
24,
477
]
],
[
[
522,
6,
8374
],
[
8374,
45,
477
]
],
[
[
522,
21,
28658
],
[
28658,
60,
477
]
],
[
[
522,
24,
112
],
[
112,
... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
]
],
[
[
"Zafirlukast",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Zafirlukast (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cilostazol (Compound)
Zafirlukast (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Cilostazol (Compound)
Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and ... |
DB08868 | DB11793 | 1,011 | 738 | [
"DDInter737",
"DDInter1297"
] | Fingolimod | Niraparib | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Major | 2 | [
[
[
1011,
25,
738
]
],
[
[
1011,
64,
1213
],
[
1213,
24,
738
]
],
[
[
1011,
24,
496
],
[
496,
24,
738
]
],
[
[
1011,
25,
1619
],
[
1619,
... | [
[
[
"Fingolimod",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Niraparib"
]
],
[
[
"Fingolimod",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
],
[
"Dasatinib",
"{u} may ... | Fingolimod may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Fingolimod may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine and Hepatitis A Vac... |
DB01073 | DB15091 | 1,488 | 676 | [
"DDInter745",
"DDInter1901"
] | Fludarabine | Upadacitinib | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
1488,
25,
676
]
],
[
[
1488,
63,
1461
],
[
1461,
23,
676
]
],
[
[
1488,
24,
1430
],
[
1430,
24,
676
]
],
[
[
1488,
63,
563
],
[
563,
... | [
[
[
"Fludarabine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Fludarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin... | Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Upadacitinib
Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipu... |
DB01100 | DB01246 | 1,568 | 820 | [
"DDInter1470",
"DDInter45"
] | Pimozide | Alimemazine | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | A phenothiazine derivative that is used as an antipruritic. | Major | 2 | [
[
[
1568,
25,
820
]
],
[
[
1568,
63,
104
],
[
104,
40,
820
]
],
[
[
1568,
64,
401
],
[
401,
24,
820
]
],
[
[
1568,
24,
649
],
[
649,
... | [
[
[
"Pimozide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alimemazine"
]
],
[
[
"Pimozide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
[
"Methdilazin... | Pimozide may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (Compound)
Pimozide may lead to a major life threatening interaction when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbat... |
DB01050 | DB01254 | 848 | 1,213 | [
"DDInter900",
"DDInter484"
] | Ibuprofen | Dasatinib | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Major | 2 | [
[
[
848,
25,
1213
]
],
[
[
848,
6,
4973
],
[
4973,
45,
1213
]
],
[
[
848,
6,
4789
],
[
4789,
57,
1213
]
],
[
[
848,
21,
28956
],
[
28956,
... | [
[
[
"Ibuprofen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
]
],
[
[
"Ibuprofen",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Dasatinib"
... | Ibuprofen (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dasatinib (Compound)
Ibuprofen (Compound) binds PPARG (Gene) and PPARG (Gene) is downregulated by Dasatinib (Compound)
Ibuprofen (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Dasatinib (Compound)
Ibuprofen ma... |
DB00782 | DB01036 | 1,123 | 211 | [
"DDInter1535",
"DDInter1832"
] | Propantheline | Tolterodine | A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. | Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence. Tolterodine acts on M2 and M3 subtypes of muscarinic receptors. | Moderate | 1 | [
[
[
1123,
24,
211
]
],
[
[
1123,
24,
358
],
[
358,
40,
211
]
],
[
[
1123,
63,
1523
],
[
1523,
40,
211
]
],
[
[
1123,
63,
128
],
[
128,
... | [
[
[
"Propantheline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolterodine"
]
],
[
[
"Propantheline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orphenadrine"
],... | Propantheline may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Orphenadrine (Compound) resembles Tolterodine (Compound)
Propantheline may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol (Compound) resembles Tolterodine (... |
DB01156 | DB09068 | 593 | 1,427 | [
"DDInter252",
"DDInter1948"
] | Bupropion | Vortioxetine | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin r... | Major | 2 | [
[
[
593,
25,
1427
]
],
[
[
593,
23,
256
],
[
256,
24,
1427
]
],
[
[
593,
24,
1604
],
[
1604,
63,
1427
]
],
[
[
593,
25,
1220
],
[
1220,
... | [
[
[
"Bupropion",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vortioxetine"
]
],
[
[
"Bupropion",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Prasugrel"
],
[
"Prasugrel",
... | Bupropion may cause a minor interaction that can limit clinical effects when taken with Prasugrel and Prasugrel may cause a moderate interaction that could exacerbate diseases when taken with Vortioxetine
Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Lumacaftor and Lumacaftor... |
DB00959 | DB06448 | 1,486 | 171 | [
"DDInter1191",
"DDInter1087"
] | Methylprednisolone | Lonafarnib | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Major | 2 | [
[
[
1486,
25,
171
]
],
[
[
1486,
40,
1351
],
[
1351,
24,
171
]
],
[
[
1486,
63,
473
],
[
473,
24,
171
]
],
[
[
1486,
24,
761
],
[
761,
... | [
[
[
"Methylprednisolone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lonafarnib"
]
],
[
[
"Methylprednisolone",
"{u} (Compound) resembles {v} (Compound)",
"Flunisolide"
],
[
"Flunisolide",
"{u} may cause a mode... | Methylprednisolone (Compound) resembles Flunisolide (Compound) and Flunisolide may cause a moderate interaction that could exacerbate diseases when taken with Lonafarnib
Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide and Repaglinide may cause a moderate in... |
DB00863 | DB01115 | 1,194 | 336 | [
"DDInter1568",
"DDInter1291"
] | Ranitidine | Nifedipine | Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as [cimetidine] and [famotidine]. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.[A176759,L10818]... | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Minor | 0 | [
[
[
1194,
23,
336
]
],
[
[
1194,
6,
7950
],
[
7950,
45,
336
]
],
[
[
1194,
21,
28695
],
[
28695,
60,
336
]
],
[
[
1194,
63,
1031
],
[
1031... | [
[
[
"Ranitidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Nifedipine"
]
],
[
[
"Ranitidine",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
... | Ranitidine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Nifedipine (Compound)
Ranitidine (Compound) causes Dyspnoea (Side Effect) and Dyspnoea (Side Effect) is caused by Nifedipine (Compound)
Ranitidine may cause a moderate interaction that could exacerbate diseases when taken with Theophylline and Theo... |
DB00349 | DB11186 | 902 | 1,609 | [
"DDInter401",
"DDInter1427"
] | Clobazam | Pentoxyverine | Clobazam belongs to the 1,5-benzodiazepine class of drugs and is marketed under different names, Onfi, Frisium, Urbanyl, and others.. Clobazam was first synthesized in 1966 and first published in 1969, following the incidental synthesis and discovery of the first benzodiazepine chlordiazepoxide in the 1950s. Unlike old... | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
902,
24,
1609
]
],
[
[
902,
24,
104
],
[
104,
24,
1609
]
],
[
[
902,
40,
523
],
[
523,
24,
1609
]
],
[
[
902,
63,
701
],
[
701,
... | [
[
[
"Clobazam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Clobazam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
[
... | Clobazam may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Clobazam (Compound) resembles Alprazolam (Compound) and Alprazolam may cause a moderate interaction that co... |
DB00189 | DB01041 | 459 | 770 | [
"DDInter691",
"DDInter1789"
] | Ethchlorvynol | Thalidomide | Ethchlorvynol is a sedative and hypnotic drug. It has been used to treat insomnia, but has been largely superseded and is only offered where an intolerance or allergy to other drugs exists. | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
459,
24,
770
]
],
[
[
459,
24,
849
],
[
849,
63,
770
]
],
[
[
459,
24,
1614
],
[
1614,
24,
770
]
],
[
[
459,
25,
475
],
[
475,
2... | [
[
[
"Ethchlorvynol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Ethchlorvynol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
... | Ethchlorvynol may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide
Ethchlorvynol may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and N... |
DB00208 | DB00261 | 1,018 | 702 | [
"DDInter1804",
"DDInter93"
] | Ticlopidine | Anagrelide | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Moderate | 1 | [
[
[
1018,
24,
702
]
],
[
[
1018,
6,
7950
],
[
7950,
45,
702
]
],
[
[
1018,
18,
10375
],
[
10375,
57,
702
]
],
[
[
1018,
21,
29549
],
[
295... | [
[
[
"Ticlopidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anagrelide"
]
],
[
[
"Ticlopidine",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)... | Ticlopidine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Anagrelide (Compound)
Ticlopidine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Anagrelide (Compound)
Ticlopidine (Compound) causes Osteoarthritis (Side Effect) and Osteoarthritis (Side Effect) is caused by Anagrelid... |
DB00748 | DB11186 | 662 | 1,609 | [
"DDInter297",
"DDInter1427"
] | Carbinoxamine | Pentoxyverine | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
662,
24,
1609
]
],
[
[
662,
24,
314
],
[
314,
24,
1609
]
],
[
[
662,
63,
556
],
[
556,
24,
1609
]
],
[
[
662,
25,
306
],
[
306,
... | [
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nalbuphine"
],... | Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Nalbuphine and Nalbuphine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Valproic aci... |
DB00220 | DB00959 | 798 | 1,486 | [
"DDInter1276",
"DDInter1191"
] | Nelfinavir | Methylprednisolone | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Major | 2 | [
[
[
798,
25,
1486
]
],
[
[
798,
25,
175
],
[
175,
40,
1486
]
],
[
[
798,
24,
167
],
[
167,
1,
1486
]
],
[
[
798,
63,
1351
],
[
1351,
... | [
[
[
"Nelfinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Nelfinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Triamcinolone"
],
[
"Triamcinolone"... | Nelfinavir may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Nelfinavir may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Methylprednisol... |
DB01030 | DB06317 | 869 | 1,626 | [
"DDInter1835",
"DDInter630"
] | Topotecan | Elotuzumab | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family... | Moderate | 1 | [
[
[
869,
24,
1626
]
],
[
[
869,
24,
973
],
[
973,
24,
1626
]
],
[
[
869,
63,
597
],
[
597,
24,
1626
]
],
[
[
869,
24,
200
],
[
200,
... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elotuzumab"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
],
[
... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Elotuzumab
Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chl... |
DB00208 | DB04896 | 1,018 | 901 | [
"DDInter1804",
"DDInter1220"
] | Ticlopidine | Milnacipran | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Milnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment of depression [F3928, F3934, A175786, A175951]. Furthermore, in 2009 the US FDA approved milnacipran for the a... | Moderate | 1 | [
[
[
1018,
24,
901
]
],
[
[
1018,
24,
41
],
[
41,
1,
901
]
],
[
[
1018,
21,
28722
],
[
28722,
60,
901
]
],
[
[
1018,
25,
405
],
[
405,
... | [
[
[
"Ticlopidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milnacipran"
]
],
[
[
"Ticlopidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
],
... | Ticlopidine may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran and Levomilnacipran (Compound) resembles Milnacipran (Compound)
Ticlopidine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Milnacipran (Compound)
Ticlopidine may lead to a major life... |
DB00682 | DB05679 | 126 | 1,683 | [
"DDInter1951",
"DDInter1907"
] | Warfarin | Ustekinumab | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Moderate | 1 | [
[
[
126,
24,
1683
]
],
[
[
126,
63,
1461
],
[
1461,
23,
1683
]
],
[
[
126,
24,
1042
],
[
1042,
24,
1683
]
],
[
[
126,
24,
1093
],
[
1093,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]
],
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ustekinumab
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Tetracosactide and Tetracosa... |
DB01142 | DB04896 | 1,264 | 901 | [
"DDInter593",
"DDInter1220"
] | Doxepin | Milnacipran | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Milnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment of depression [F3928, F3934, A175786, A175951]. Furthermore, in 2009 the US FDA approved milnacipran for the a... | Major | 2 | [
[
[
1264,
25,
901
]
],
[
[
1264,
25,
41
],
[
41,
1,
901
]
],
[
[
1264,
64,
1349
],
[
1349,
40,
901
]
],
[
[
1264,
6,
6112
],
[
6112,
... | [
[
[
"Doxepin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Milnacipran"
]
],
[
[
"Doxepin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Levomilnacipran"
],
[
"Levomilnacipran",
"... | Doxepin may lead to a major life threatening interaction when taken with Levomilnacipran and Levomilnacipran (Compound) resembles Milnacipran (Compound)
Doxepin may lead to a major life threatening interaction when taken with Meperidine and Meperidine (Compound) resembles Milnacipran (Compound)
Doxepin (Compound) binds... |
DB01309 | DB08822 | 1,254 | 911 | [
"DDInter933",
"DDInter156"
] | Insulin glulisine | Azilsartan medoxomil | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Azilsartan medoxomil is a prodrug that is broken down to azilsartan, which belongs in the angiotensin-receptor blocking (ARB) drug class. It is a selective AT1 subtype angiotensin II receptor antagonist. Azilsartan medoxomil is a relatively recently-developed antihypertensive drug that was first approved by the FDA in ... | Moderate | 1 | [
[
[
1254,
24,
911
]
],
[
[
1254,
63,
217
],
[
217,
1,
911
]
],
[
[
1254,
24,
1450
],
[
1450,
63,
911
]
],
[
[
1254,
24,
549
],
[
549,
... | [
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azilsartan medoxomil"
]
],
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olm... | Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Olmesartan and Olmesartan (Compound) resembles Azilsartan medoxomil (Compound)
Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may cause a m... |
DB01579 | DB06704 | 341 | 247 | [
"DDInter1439",
"DDInter951"
] | Phendimetrazine | Iobenguane (I-123) | Phendimetrazine is a weight loss medication. Phendimetrazine is chemically related to amphetamines and is a Schedule III drug under the Convention on Psychotropic Substances and in the US since 1970. | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Moderate | 1 | [
[
[
341,
37,
247
]
],
[
[
341,
6,
7390
],
[
7390,
45,
247
]
],
[
[
341,
21,
28921
],
[
28921,
60,
247
]
],
[
[
341,
63,
820
],
[
820,
... | [
[
[
"Phendimetrazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v}",
"Iobenguane"
]
],
[
[
"Phendimetrazine",
"{u} (Compound) binds {v} (Gene)",
... | Phendimetrazine may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane and Phendimetrazine may lead to a major life threatening interaction when taken with Iobenguane
Phendimetrazine (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Iobenguane (Compound)
Phendimetrazine (C... |
DB11642 | DB11691 | 938 | 1,499 | [
"DDInter1480",
"DDInter1258"
] | Pitolisant | Naldemedine | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Naldemedine is an opioid receptor antagonist [FDA Label]. It is a modified form of to which a side chain has been added to increase molecular weight and polar surface area resulting in restricted transport across the blood brain barrier. Naldemedine was approved in 2017 in both the US and Japan for the treatment of Opi... | Moderate | 1 | [
[
[
938,
24,
1499
]
],
[
[
938,
63,
1159
],
[
1159,
24,
1499
]
],
[
[
938,
64,
1593
],
[
1593,
24,
1499
]
],
[
[
938,
24,
283
],
[
283,
... | [
[
[
"Pitolisant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naldemedine"
]
],
[
[
"Pitolisant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylnaltrexone"
],
... | Pitolisant may cause a moderate interaction that could exacerbate diseases when taken with Methylnaltrexone and Methylnaltrexone may cause a moderate interaction that could exacerbate diseases when taken with Naldemedine
Pitolisant may lead to a major life threatening interaction when taken with Crizotinib and Crizotin... |
DB00069 | DB09115 | 367 | 505 | [
"DDInter946",
"DDInter559"
] | Interferon alfacon-1 | Diiodohydroxyquinoline | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Diiodohydroxyquinoline, also known as uidoquinol and iodoquinol, is a quinoline derivative that can be used in the treatment of amoebiasis. The exact mechanism of action is unknown. Iodoquinol is not currently available in any FDA-approved products. | Moderate | 1 | [
[
[
367,
24,
505
]
],
[
[
367,
24,
1593
],
[
1593,
24,
505
]
],
[
[
367,
25,
1510
],
[
1510,
24,
505
]
],
[
[
367,
24,
1434
],
[
1434,
... | [
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diiodohydroxyquinoline"
]
],
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Diiodohydroxyquinoline
Interferon alfacon-1 may lead to a major life threatening interaction when taken with Teri... |
DB00831 | DB12141 | 1,178 | 971 | [
"DDInter1866",
"DDInter817"
] | Trifluoperazine | Gilteritinib | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
1178,
24,
971
]
],
[
[
1178,
23,
112
],
[
112,
23,
971
]
],
[
[
1178,
63,
485
],
[
485,
24,
971
]
],
[
[
1178,
24,
823
],
[
823,
... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Trifluoperazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
... | Trifluoperazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Pentami... |
DB06694 | DB06704 | 31 | 247 | [
"DDInter1952",
"DDInter952"
] | Xylometazoline (nasal) | Iobenguane (I-131) | Xylometazoline is an alkylbenzene. | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Major | 2 | [
[
[
31,
25,
247
]
],
[
[
31,
63,
1161
],
[
1161,
25,
247
]
],
[
[
31,
24,
1629
],
[
1629,
64,
247
]
],
[
[
31,
63,
1100
],
[
1100,
3... | [
[
[
"Xylometazoline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iobenguane"
]
],
[
[
"Xylometazoline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Selegiline"
],
[
"Se... | Xylometazoline may lead to a major life threatening interaction when taken with Iobenguane
Xylometazoline may cause a moderate interaction that could exacerbate diseases when taken with Selegiline and Selegiline may lead to a major life threatening interaction when taken with Iobenguane
Xylometazoline may cause a moder... |
DB00562 | DB06203 | 1,014 | 1,002 | [
"DDInter188",
"DDInter51"
] | Benzthiazide | Alogliptin | Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used... | Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25,... | Moderate | 1 | [
[
[
1014,
24,
1002
]
],
[
[
1014,
24,
1281
],
[
1281,
40,
1002
]
],
[
[
1014,
40,
504
],
[
504,
24,
1002
]
],
[
[
1014,
24,
401
],
[
401,
... | [
[
[
"Benzthiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
]
],
[
[
"Benzthiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
],
... | Benzthiazide may cause a moderate interaction that could exacerbate diseases when taken with Linagliptin and Linagliptin (Compound) resembles Alogliptin (Compound)
Benzthiazide (Compound) resembles Hydrochlorothiazide (Compound) and Hydrochlorothiazide may cause a moderate interaction that could exacerbate diseases whe... |
DB00295 | DB00405 | 475 | 128 | [
"DDInter1244",
"DDInter517"
] | Morphine | Dexbrompheniramine | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Moderate | 1 | [
[
[
475,
24,
128
]
],
[
[
475,
24,
662
],
[
662,
63,
128
]
],
[
[
475,
25,
508
],
[
508,
63,
128
]
],
[
[
475,
24,
556
],
[
556,
24,... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexbrompheniramine"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine
Morphine may lead to a major life threatening interaction when taken with Promazine and Promazine ma... |
DB06290 | DB11581 | 1,449 | 1,456 | [
"DDInter1673",
"DDInter1926"
] | Simeprevir | Venetoclax | Simeprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor indicated in patient's with HCV genotype 1 for the treatment of chronic hepatitis C virus (HCV) infection. HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, an... | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Major | 2 | [
[
[
1449,
25,
1456
]
],
[
[
1449,
24,
466
],
[
466,
63,
1456
]
],
[
[
1449,
63,
126
],
[
126,
24,
1456
]
],
[
[
1449,
25,
498
],
[
498,
... | [
[
[
"Simeprevir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Venetoclax"
]
],
[
[
"Simeprevir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
"Daroluta... | Simeprevir may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a moderate interaction that could exacerbate diseases when taken with Venetoclax
Simeprevir may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warf... |
DB00514 | DB04868 | 506 | 478 | [
"DDInter527",
"DDInter1293"
] | Dextromethorphan | Nilotinib | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Moderate | 1 | [
[
[
506,
24,
478
]
],
[
[
506,
6,
6017
],
[
6017,
45,
478
]
],
[
[
506,
7,
3727
],
[
3727,
46,
478
]
],
[
[
506,
21,
28769
],
[
28769,
... | [
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]
],
[
[
"Dextromethorphan",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (... | Dextromethorphan (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Nilotinib (Compound)
Dextromethorphan (Compound) upregulates MAL (Gene) and MAL (Gene) is upregulated by Nilotinib (Compound)
Dextromethorphan (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Ni... |
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