drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00877 | DB09389 | 629 | 517 | [
"DDInter1678",
"DDInter1315"
] | Sirolimus | Norgestrel | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Norgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantiomer ([levonorgestrel]) is biologically active. | Moderate | 1 | [
[
[
629,
24,
517
]
],
[
[
629,
24,
1130
],
[
1130,
23,
517
]
],
[
[
629,
24,
52
],
[
52,
24,
517
]
],
[
[
629,
24,
159
],
[
159,
63,... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norgestrel"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitazone"
],
[
... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Pioglitazone and Pioglitazone may cause a minor interaction that can limit clinical effects when taken with Norgestrel
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Dulaglutide and Dulag... |
DB01009 | DB08870 | 935 | 850 | [
"DDInter1009",
"DDInter228"
] | Ketoprofen | Brentuximab vedotin | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
935,
24,
850
]
],
[
[
935,
63,
267
],
[
267,
24,
850
]
],
[
[
935,
24,
1033
],
[
1033,
63,
850
]
],
[
[
935,
40,
886
],
[
886,
2... | [
[
[
"Ketoprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Ketoprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
],... | Ketoprofen may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Ketoprofen may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib an... |
DB00108 | DB12893 | 1,066 | 586 | [
"DDInter1268",
"DDInter1629"
] | Natalizumab | Sacituzumab govitecan | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | Metastatic triple-negative breast cancer (mTNBC) is an aggressive form of breast cancer with limited treatment options involving cytotoxic chemotherapy agents. Targeted chemotherapy through the application of antibody-conjugated agents (ADCs) is a recent advance in cancer treatment. One such ADC is sacituzumab goviteca... | Major | 2 | [
[
[
1066,
25,
586
]
],
[
[
1066,
25,
270
],
[
270,
24,
586
]
],
[
[
1066,
64,
58
],
[
58,
24,
586
]
],
[
[
1066,
25,
1377
],
[
1377,
... | [
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sacituzumab govitecan"
]
],
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ocrelizumab"
],
[
"Ocrelizumab... | Natalizumab may lead to a major life threatening interaction when taken with Ocrelizumab and Ocrelizumab may cause a moderate interaction that could exacerbate diseases when taken with Sacituzumab govitecan
Natalizumab may lead to a major life threatening interaction when taken with Alefacept and Alefacept may cause a ... |
DB00313 | DB00470 | 556 | 530 | [
"DDInter1913",
"DDInter601"
] | Valproic acid | Dronabinol | Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investig... | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Moderate | 1 | [
[
[
556,
24,
530
]
],
[
[
556,
24,
1614
],
[
1614,
40,
530
]
],
[
[
556,
6,
6017
],
[
6017,
45,
530
]
],
[
[
556,
21,
29226
],
[
29226,
... | [
[
[
"Valproic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
]
],
[
[
"Valproic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
],
... | Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabilone (Compound) resembles Dronabinol (Compound)
Valproic acid (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Dronabinol (Compound)
Valproic acid (Compound) causes Sinusitis (Side Effect) and Sinu... |
DB08908 | DB11003 | 713 | 748 | [
"DDInter564",
"DDInter100"
] | Dimethyl fumarate | Anthrax vaccine | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsula... | Moderate | 1 | [
[
[
713,
24,
748
]
],
[
[
713,
63,
322
],
[
322,
24,
748
]
],
[
[
713,
24,
564
],
[
564,
63,
748
]
],
[
[
713,
25,
676
],
[
676,
63,... | [
[
[
"Dimethyl fumarate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
]
],
[
[
"Dimethyl fumarate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubic... | Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine
Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Ab... |
DB09312 | DB10343 | 967 | 962 | [
"DDInter103",
"DDInter160"
] | Antilymphocyte immunoglobulin (horse) | Bacillus calmette-guerin substrain tice live antigen | Equine anti-thymocyte globulin is composed of purified gamma globulin containing primarily IgG against human thymus lymphocytes. It is formed by inoculating a horse with an antigen (human thymoyctes) which then induces the horse immune system's B-lymphocytes to produce IgG immunoglobulins specific for that antigen. The... | Bacillus calmette-guerin substrain tice live antigen is a vaccine containing attenuated live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of *Mycobacterium bovis* for percutaneous use. It is administered to prevent the development of tuberculosis. | Major | 2 | [
[
[
967,
25,
962
]
],
[
[
967,
64,
1057
],
[
1057,
25,
962
]
],
[
[
967,
24,
270
],
[
270,
64,
962
]
],
[
[
967,
25,
976
],
[
976,
2... | [
[
[
"Antilymphocyte immunoglobulin (horse)",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bacillus calmette-guerin substrain tice live antigen"
]
],
[
[
"Antilymphocyte immunoglobulin (horse)",
"{u} may lead to a major life threatening in... | Antilymphocyte immunoglobulin (horse) may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Bacillus calmette-guerin substrain tice live antigen
Antilymphocyte immunoglobulin (horse) may cause a moderate interaction th... |
DB00911 | DB11952 | 458 | 800 | [
"DDInter1811",
"DDInter612"
] | Tinidazole | Duvelisib | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Moderate | 1 | [
[
[
458,
24,
800
]
],
[
[
458,
24,
310
],
[
310,
24,
800
]
],
[
[
458,
63,
467
],
[
467,
24,
800
]
],
[
[
458,
24,
1476
],
[
1476,
6... | [
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
]
],
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib
Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simv... |
DB01115 | DB14723 | 336 | 159 | [
"DDInter1291",
"DDInter1026"
] | Nifedipine | Larotrectinib | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
336,
24,
159
]
],
[
[
336,
23,
466
],
[
466,
23,
159
]
],
[
[
336,
24,
98
],
[
98,
24,
159
]
],
[
[
336,
63,
11
],
[
11,
24,
... | [
[
[
"Nifedipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Nifedipine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
],
[... | Nifedipine may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somat... |
DB00439 | DB06589 | 289 | 1,250 | [
"DDInter341",
"DDInter1400"
] | Cerivastatin | Pazopanib | On August 8, 2001 the U.S. Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew Baycol from the U.S. market, due to reports of fatal rhabdomyolysis, a severe adverse reaction from this cholesterol-lowering (lipid-lowering) product. It has also been withdrawn from the Cana... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
289,
24,
1250
]
],
[
[
289,
24,
112
],
[
112,
23,
1250
]
],
[
[
289,
24,
14
],
[
14,
24,
1250
]
],
[
[
289,
24,
214
],
[
214,
63... | [
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pazopanib
Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin a... |
DB00238 | DB00773 | 188 | 896 | [
"DDInter1285",
"DDInter702"
] | Nevirapine | Etoposide | A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class. | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Moderate | 1 | [
[
[
188,
24,
896
]
],
[
[
188,
6,
7524
],
[
7524,
45,
896
]
],
[
[
188,
21,
28681
],
[
28681,
60,
896
]
],
[
[
188,
24,
147
],
[
147,
... | [
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
]
],
[
[
"Nevirapine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)",
... | Nevirapine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Etoposide (Compound)
Nevirapine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Etoposide (Compound)
Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Vinblas... |
DB00916 | DB08864 | 112 | 786 | [
"DDInter1202",
"DDInter1595"
] | Metronidazole | Rilpivirine | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients. It is a diarylpyrimidine derivative. The internal conformational flexibility of rilpivirine and the plasticity of it interacting binding site gives it a very high potenc... | Minor | 0 | [
[
[
112,
23,
786
]
],
[
[
112,
24,
655
],
[
655,
1,
786
]
],
[
[
112,
6,
8374
],
[
8374,
45,
786
]
],
[
[
112,
21,
28734
],
[
28734,
... | [
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Rilpivirine"
]
],
[
[
"Metronidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
],
... | Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Etravirine and Etravirine (Compound) resembles Rilpivirine (Compound)
Metronidazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rilpivirine (Compound)
Metronidazole (Compound) causes Immune system disorder (Si... |
DB00434 | DB04948 | 13 | 1,084 | [
"DDInter459",
"DDInter1083"
] | Cyproheptadine | Lofexidine | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hyp... | Moderate | 1 | [
[
[
13,
24,
1084
]
],
[
[
13,
24,
1617
],
[
1617,
1,
1084
]
],
[
[
13,
6,
8742
],
[
8742,
45,
1084
]
],
[
[
13,
24,
1311
],
[
1311,
... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lofexidine"
]
],
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apraclonidine"
... | Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Apraclonidine and Apraclonidine (Compound) resembles Lofexidine (Compound)
Cyproheptadine (Compound) binds HTR1A (Gene) and HTR1A (Gene) is bound by Lofexidine (Compound)
Cyproheptadine may cause a moderate interaction that c... |
DB00015 | DB14006 | 582 | 972 | [
"DDInter1585",
"DDInter370"
] | Reteplase | Choline salicylate | Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids p... | Choline salicylate is an anti-inflammatory pain reliever agent that is related to aspirin. It is used to decrease swelling and to treat mild-moderate pain. It is used to treat arthritis in both children and adults. This medicine can also be used for fever . Choline Salicylate is the choline salt of salicylic acid, used... | Moderate | 1 | [
[
[
582,
24,
972
]
],
[
[
582,
25,
553
],
[
553,
24,
972
]
],
[
[
582,
24,
885
],
[
885,
24,
972
]
],
[
[
582,
64,
1578
],
[
1578,
2... | [
[
[
"Reteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Choline salicylate"
]
],
[
[
"Reteplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fondaparinux"
],
[
"Fo... | Reteplase may lead to a major life threatening interaction when taken with Fondaparinux and Fondaparinux may cause a moderate interaction that could exacerbate diseases when taken with Choline salicylate
Reteplase may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoproste... |
DB01156 | DB04868 | 593 | 478 | [
"DDInter252",
"DDInter1293"
] | Bupropion | Nilotinib | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Moderate | 1 | [
[
[
593,
24,
478
]
],
[
[
593,
6,
6017
],
[
6017,
45,
478
]
],
[
[
593,
7,
2692
],
[
2692,
45,
478
]
],
[
[
593,
7,
7972
],
[
7972,
... | [
[
[
"Bupropion",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]
],
[
[
"Bupropion",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
... | Bupropion (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Nilotinib (Compound)
Bupropion (Compound) upregulates KIT (Gene) and KIT (Gene) is bound by Nilotinib (Compound)
Bupropion (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Nilotinib (Compound)
Bupropion (Compound) downregul... |
DB00278 | DB00472 | 291 | 758 | [
"DDInter117",
"DDInter758"
] | Argatroban | Fluoxetine | Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant sh... | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Moderate | 1 | [
[
[
291,
24,
758
]
],
[
[
291,
24,
109
],
[
109,
40,
758
]
],
[
[
291,
6,
8374
],
[
8374,
45,
758
]
],
[
[
291,
21,
28810
],
[
28810,
... | [
[
[
"Argatroban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxetine"
]
],
[
[
"Argatroban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duloxetine"
],
[
... | Argatroban may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxetine (Compound) resembles Fluoxetine (Compound)
Argatroban (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fluoxetine (Compound)
Argatroban (Compound) causes Gastrointestinal pain (Side Effect) a... |
DB00372 | DB11827 | 999 | 433 | [
"DDInter1793",
"DDInter669"
] | Thiethylperazine | Ertugliflozin | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
999,
24,
433
]
],
[
[
999,
24,
1020
],
[
1020,
24,
433
]
],
[
[
999,
63,
695
],
[
695,
24,
433
]
],
[
[
999,
62,
417
],
[
417,
2... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clonidine"
... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Clonidine and Clonidine may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Clozapin... |
DB00622 | DB01143 | 1,081 | 923 | [
"DDInter1287",
"DDInter65"
] | Nicardipine | Amifostine | A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [Pub... | A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia. | Moderate | 1 | [
[
[
1081,
24,
923
]
],
[
[
1081,
21,
29789
],
[
29789,
60,
923
]
],
[
[
1081,
40,
336
],
[
336,
24,
923
]
],
[
[
1081,
24,
714
],
[
714,
... | [
[
[
"Nicardipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amifostine"
]
],
[
[
"Nicardipine",
"{u} (Compound) causes {v} (Side Effect)",
"Supraventricular tachycardia"
],
[
"Supraventricular tachyc... | Nicardipine (Compound) causes Supraventricular tachycardia (Side Effect) and Supraventricular tachycardia (Side Effect) is caused by Amifostine (Compound)
Nicardipine (Compound) resembles Nifedipine (Compound) and Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Amifostine
Nica... |
DB00988 | DB01124 | 817 | 1,411 | [
"DDInter584",
"DDInter1828"
] | Dopamine | Tolbutamide | One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action. | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
817,
24,
1411
]
],
[
[
817,
24,
959
],
[
959,
40,
1411
]
],
[
[
817,
63,
245
],
[
245,
40,
1411
]
],
[
[
817,
6,
10215
],
[
10215,
... | [
[
[
"Dopamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Dopamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Dopamine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Dopamine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Tolbutamide (Compound)
Do... |
DB06782 | DB14491 | 1,575 | 428 | [
"DDInter563",
"DDInter725"
] | Dimercaprol | Ferrous fumarate | Dimercaprol is a traditional chelating agent developed by British biochemists at Oxford University during World War II. It was developed as an experimental antidote against the arsenic-based poison gas Lewisite. It has been used clinically since 1949 in arsenic, cadmium and mercury poisoning. In addition, it has in the... | Used in treatment of iron deficiency anemia. | Major | 2 | [
[
[
1575,
25,
428
]
],
[
[
1575,
25,
174
],
[
174,
63,
428
]
],
[
[
1575,
64,
1656
],
[
1656,
24,
428
]
],
[
[
1575,
25,
1608
],
[
1608,
... | [
[
[
"Dimercaprol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ferrous fumarate"
]
],
[
[
"Dimercaprol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ferric derisomaltose"
],
[
"Ferric ... | Dimercaprol may lead to a major life threatening interaction when taken with Ferric derisomaltose and Ferric derisomaltose may cause a moderate interaction that could exacerbate diseases when taken with Ferrous fumarate
Dimercaprol may lead to a major life threatening interaction when taken with Iron Dextran and Iron D... |
DB01035 | DB08895 | 1,401 | 976 | [
"DDInter1524",
"DDInter1825"
] | Procainamide | Tofacitinib | A derivative of procaine with less CNS action. | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Moderate | 1 | [
[
[
1401,
24,
976
]
],
[
[
1401,
25,
982
],
[
982,
63,
976
]
],
[
[
1401,
25,
868
],
[
868,
24,
976
]
],
[
[
1401,
74,
608
],
[
608,
... | [
[
[
"Procainamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib"
]
],
[
[
"Procainamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
],
[
"Ivosi... | Procainamide may lead to a major life threatening interaction when taken with Ivosidenib and Ivosidenib may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib
Procainamide may lead to a major life threatening interaction when taken with Vemurafenib and Vemurafenib may cause a modera... |
DB00193 | DB00261 | 534 | 702 | [
"DDInter1841",
"DDInter93"
] | Tramadol | Anagrelide | Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatmen... | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Major | 2 | [
[
[
534,
25,
702
]
],
[
[
534,
18,
4884
],
[
4884,
57,
702
]
],
[
[
534,
21,
29122
],
[
29122,
60,
702
]
],
[
[
534,
23,
112
],
[
112,
... | [
[
[
"Tramadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Anagrelide"
]
],
[
[
"Tramadol",
"{u} (Compound) downregulates {v} (Gene)",
"POLR2I"
],
[
"POLR2I",
"{u} (Gene) is downregulated by {v} (Compound)",
... | Tramadol (Compound) downregulates POLR2I (Gene) and POLR2I (Gene) is downregulated by Anagrelide (Compound)
Tramadol (Compound) causes Mediastinal disorder (Side Effect) and Mediastinal disorder (Side Effect) is caused by Anagrelide (Compound)
Tramadol may cause a minor interaction that can limit clinical effects when ... |
DB00658 | DB00910 | 965 | 1,041 | [
"DDInter1663",
"DDInter1394"
] | Sevelamer | Paricalcitol | Sevelamer is a phosphate binding drug used to prevent hyperphosphataemia in patients with chronic renal failure. It is marketed by Genzyme under the trade name Renagel. | Paricalcitol is a synthetic vitamin D analog. Paricalcitol has been used to reduce parathyroid hormone levels. Paricalcitol is indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure. | Moderate | 1 | [
[
[
965,
24,
1041
]
],
[
[
965,
63,
386
],
[
386,
25,
1041
]
],
[
[
965,
24,
1098
],
[
1098,
64,
1041
]
],
[
[
965,
21,
28709
],
[
28709,
... | [
[
[
"Sevelamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paricalcitol"
]
],
[
[
"Sevelamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cholecalciferol"
],
... | Sevelamer may cause a moderate interaction that could exacerbate diseases when taken with Cholecalciferol and Cholecalciferol may lead to a major life threatening interaction when taken with Paricalcitol
Sevelamer may cause a moderate interaction that could exacerbate diseases when taken with Dihydrotachysterol and Dih... |
DB01618 | DB06282 | 776 | 516 | [
"DDInter1239",
"DDInter1053"
] | Molindone | Levocetirizine | An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to mo... | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
776,
24,
516
]
],
[
[
776,
63,
701
],
[
701,
24,
516
]
],
[
[
776,
24,
407
],
[
407,
63,
516
]
],
[
[
776,
24,
649
],
[
649,
24,... | [
[
[
"Molindone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Molindone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
[
... | Molindone may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine
Molindone may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may... |
DB00352 | DB00976 | 482 | 1,056 | [
"DDInter1814",
"DDInter1758"
] | Tioguanine | Telithromycin | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Moderate | 1 | [
[
[
482,
24,
1056
]
],
[
[
482,
63,
1570
],
[
1570,
40,
1056
]
],
[
[
482,
21,
28826
],
[
28826,
60,
1056
]
],
[
[
482,
24,
79
],
[
79,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telithromycin"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],
... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin (Compound) resembles Telithromycin (Compound)
Tioguanine (Compound) causes Jaundice (Side Effect) and Jaundice (Side Effect) is caused by Telithromycin (Compound)
Tioguanine may cause a moderate inte... |
DB00364 | DB06410 | 417 | 1,196 | [
"DDInter1717",
"DDInter595"
] | Sucralfate | Doxercalciferol | Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia. It is considered a _cytoprotective agent_, protect... | Doxercalciferol is a synthetic vitamin D2 analog that undergoes metabolic activation in vivo to form 1α,25-dihydroxyvitamin D2 (1α,25-(OH)2D2), a naturally occurring, biologically active form of vitamin D2. Doxercalciferol is indicated for the treatment of secondary hyperparathyroidism in patients with chronic kidney d... | Major | 2 | [
[
[
417,
25,
1196
]
],
[
[
417,
63,
362
],
[
362,
24,
1196
]
],
[
[
417,
24,
286
],
[
286,
63,
1196
]
],
[
[
417,
24,
1252
],
[
1252,
... | [
[
[
"Sucralfate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Doxercalciferol"
]
],
[
[
"Sucralfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
[
"Phenyt... | Sucralfate may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Doxercalciferol
Sucralfate may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxid... |
DB00983 | DB11978 | 480 | 124 | [
"DDInter776",
"DDInter822"
] | Formoterol | Glasdegib | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
480,
24,
124
]
],
[
[
480,
24,
1079
],
[
1079,
24,
124
]
],
[
[
480,
24,
1032
],
[
1032,
63,
124
]
],
[
[
480,
63,
79
],
[
79,
2... | [
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telavancin"
],
[
... | Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Telavancin and Telavancin may cause a moderate interaction that could exacerbate diseases when taken with Glasdegib
Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Levosalbutamol and Lev... |
DB03904 | DB11057 | 1,574 | 720 | [
"DDInter1903",
"DDInter1223"
] | Urea | Mineral oil | A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids. | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
1574,
24,
720
]
],
[
[
1574,
63,
758
],
[
758,
24,
720
]
],
[
[
1574,
63,
758
],
[
758,
24,
927
],
[
927,
63,
720
]
],
[
[
1574,
... | [
[
[
"Urea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Urea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxetine"
],
[
"Fluoxe... | Urea may cause a moderate interaction that could exacerbate diseases when taken with Fluoxetine and Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Urea may cause a moderate interaction that could exacerbate diseases when taken with Fluoxetine and Fluoxetine may ca... |
DB00673 | DB01076 | 723 | 700 | [
"DDInter112",
"DDInter133"
] | Aprepitant | Atorvastatin | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Moderate | 1 | [
[
[
723,
24,
700
]
],
[
[
723,
24,
1080
],
[
1080,
1,
700
]
],
[
[
723,
6,
10215
],
[
10215,
45,
700
]
],
[
[
723,
63,
303
],
[
303,
... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atorvastatin"
]
],
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Conivaptan"
],
[
... | Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Conivaptan and Conivaptan (Compound) resembles Atorvastatin (Compound)
Aprepitant (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Atorvastatin (Compound)
Aprepitant may cause a moderate interaction that could exace... |
DB00370 | DB11730 | 1,251 | 351 | [
"DDInter1230",
"DDInter1588"
] | Mirtazapine | Ribociclib | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
1251,
24,
351
]
],
[
[
1251,
23,
112
],
[
112,
23,
351
]
],
[
[
1251,
25,
222
],
[
222,
23,
351
]
],
[
[
1251,
24,
283
],
[
283,
... | [
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Mirtazapine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[... | Mirtazapine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Mirtazapine may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may ... |
DB00712 | DB06228 | 1,274 | 792 | [
"DDInter763",
"DDInter1609"
] | Flurbiprofen | Rivaroxaban | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Major | 2 | [
[
[
1274,
25,
792
]
],
[
[
1274,
21,
28703
],
[
28703,
60,
792
]
],
[
[
1274,
23,
297
],
[
297,
62,
792
]
],
[
[
1274,
24,
1412
],
[
1412,... | [
[
[
"Flurbiprofen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Flurbiprofen",
"{u} (Compound) causes {v} (Side Effect)",
"Pruritus"
],
[
"Pruritus",
"{u} (Side Effect) is caused by {v} (C... | Flurbiprofen (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Rivaroxaban (Compound)
Flurbiprofen may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Rivaroxaban
Flurbi... |
DB06663 | DB14761 | 1,154 | 242 | [
"DDInter1398",
"DDInter1578"
] | Pasireotide | Remdesivir | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends o... | Moderate | 1 | [
[
[
1154,
24,
242
]
],
[
[
1154,
63,
1130
],
[
1130,
24,
242
]
],
[
[
1154,
64,
1377
],
[
1377,
24,
242
]
],
[
[
1154,
25,
129
],
[
129,
... | [
[
[
"Pasireotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
]
],
[
[
"Pasireotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitazone"
],
... | Pasireotide may cause a moderate interaction that could exacerbate diseases when taken with Pioglitazone and Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir
Pasireotide may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide ma... |
DB00691 | DB11827 | 1,058 | 433 | [
"DDInter1237",
"DDInter669"
] | Moexipril | Ertugliflozin | Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney prob... | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
1058,
24,
433
]
],
[
[
1058,
24,
959
],
[
959,
24,
433
]
],
[
[
1058,
63,
251
],
[
251,
24,
433
]
],
[
[
1058,
1,
954
],
[
954,
... | [
[
[
"Moexipril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Moexipril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Moexipril may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Moexipril may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Beta... |
DB00022 | DB00495 | 268 | 139 | [
"DDInter1408",
"DDInter1961"
] | Peginterferon alfa-2b | Zidovudine | Peginterferon alfa-2b is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain... | Major | 2 | [
[
[
268,
25,
139
]
],
[
[
268,
25,
1477
],
[
1477,
40,
139
]
],
[
[
268,
24,
231
],
[
231,
40,
139
]
],
[
[
268,
24,
309
],
[
309,
6... | [
[
[
"Peginterferon alfa-2b",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zidovudine"
]
],
[
[
"Peginterferon alfa-2b",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Telbivudine"
],
[
"Te... | Peginterferon alfa-2b may lead to a major life threatening interaction when taken with Telbivudine and Telbivudine (Compound) resembles Zidovudine (Compound)
Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Stavudine and Stavudine (Compound) resembles Zidovudine (Com... |
DB00468 | DB00675 | 1,424 | 888 | [
"DDInter1557",
"DDInter1744"
] | Quinine | Tamoxifen | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Moderate | 1 | [
[
[
1424,
24,
888
]
],
[
[
1424,
24,
675
],
[
675,
25,
888
]
],
[
[
1424,
25,
543
],
[
543,
63,
888
]
],
[
[
1424,
6,
6365
],
[
6365,
... | [
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tamoxifen"
]
],
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextropropoxyphene"
],
[
... | Quinine may cause a moderate interaction that could exacerbate diseases when taken with Dextropropoxyphene and Dextropropoxyphene may lead to a major life threatening interaction when taken with Tamoxifen
Quinine may lead to a major life threatening interaction when taken with Loperamide and Loperamide may cause a mode... |
DB00460 | DB08912 | 612 | 1,040 | [
"DDInter1929",
"DDInter462"
] | Verteporfin | Dabrafenib | Verteporfin, marketed as Visudyne, is a benzoporphyrin derivative. It is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 693 n... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
612,
24,
1040
]
],
[
[
612,
21,
29343
],
[
29343,
60,
1040
]
],
[
[
612,
63,
1101
],
[
1101,
23,
1040
]
],
[
[
612,
24,
1409
],
[
1409... | [
[
[
"Verteporfin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Verteporfin",
"{u} (Compound) causes {v} (Side Effect)",
"Blood creatinine increased"
],
[
"Blood creatinine increase... | Verteporfin (Compound) causes Blood creatinine increased (Side Effect) and Blood creatinine increased (Side Effect) is caused by Dabrafenib (Compound)
Verteporfin may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinic... |
DB00783 | DB11979 | 1,438 | 1,320 | [
"DDInter679",
"DDInter625"
] | Estradiol | Elagolix | Estradiol is a naturally occurring hormone circulating endogenously in females. It is commercially available in several hormone therapy products for managing conditions associated with reduced estrogen, such as vulvovaginal atrophy and hot flashes. Some available forms of estradiol include oral tablets, injections, vag... | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
1438,
24,
1320
]
],
[
[
1438,
24,
129
],
[
129,
24,
1320
]
],
[
[
1438,
63,
597
],
[
597,
24,
1320
]
],
[
[
1438,
24,
159
],
[
159,
... | [
[
[
"Estradiol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Estradiol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
[
... | Estradiol may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Elagolix
Estradiol may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and C... |
DB00749 | DB08870 | 59 | 850 | [
"DDInter699",
"DDInter228"
] | Etodolac | Brentuximab vedotin | Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
59,
24,
850
]
],
[
[
59,
63,
267
],
[
267,
24,
850
]
],
[
[
59,
25,
1468
],
[
1468,
63,
850
]
],
[
[
59,
24,
50
],
[
50,
24,
... | [
[
[
"Etodolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Etodolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
],
... | Etodolac may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Etodolac may lead to a major life threatening interaction when taken with Ponatinib and Ponatinib may cau... |
DB00046 | DB06655 | 1,179 | 5 | [
"DDInter940",
"DDInter1077"
] | Insulin lispro | Liraglutide | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Moderate | 1 | [
[
[
1179,
24,
5
]
],
[
[
1179,
23,
1103
],
[
1103,
23,
5
]
],
[
[
1179,
24,
743
],
[
743,
23,
5
]
],
[
[
1179,
24,
1142
],
[
1142,
2... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liraglutide"
]
],
[
[
"Insulin lispro",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
],
... | Insulin lispro may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Liraglutide
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Lisinopril and L... |
DB00749 | DB06603 | 59 | 39 | [
"DDInter699",
"DDInter1387"
] | Etodolac | Panobinostat | Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
59,
25,
39
]
],
[
[
59,
63,
912
],
[
912,
24,
39
]
],
[
[
59,
24,
578
],
[
578,
63,
39
]
],
[
[
59,
23,
1559
],
[
1559,
24,
... | [
[
[
"Etodolac",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Etodolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Interferon beta-1a"
],
[
"Inte... | Etodolac may cause a moderate interaction that could exacerbate diseases when taken with Interferon beta-1a and Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Panobinostat
Etodolac may cause a moderate interaction that could exacerbate diseases when taken with Ticagre... |
DB00308 | DB01218 | 347 | 1,493 | [
"DDInter901",
"DDInter852"
] | Ibutilide | Halofantrine | Ibutilide is a Class III antiarrhythmic agent available in intravenous formulations. It is indicated for the conversion of acute atrial flutter and recent onset atrial fibrillation to normal sinus rhythm (NSR). | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Major | 2 | [
[
[
347,
25,
1493
]
],
[
[
347,
6,
3958
],
[
3958,
45,
1493
]
],
[
[
347,
21,
28762
],
[
28762,
60,
1493
]
],
[
[
347,
23,
112
],
[
112,
... | [
[
[
"Ibutilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Halofantrine"
]
],
[
[
"Ibutilide",
"{u} (Compound) binds {v} (Gene)",
"KCNH2"
],
[
"KCNH2",
"{u} (Gene) is bound by {v} (Compound)",
"Halofantr... | Ibutilide (Compound) binds KCNH2 (Gene) and KCNH2 (Gene) is bound by Halofantrine (Compound)
Ibutilide (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Halofantrine (Compound)
Ibutilide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metron... |
DB00026 | DB09073 | 1,184 | 951 | [
"DDInter94",
"DDInter1379"
] | Anakinra | Palbociclib | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Moderate | 1 | [
[
[
1184,
24,
951
]
],
[
[
1184,
24,
496
],
[
496,
63,
951
]
],
[
[
1184,
24,
1454
],
[
1454,
24,
951
]
],
[
[
1184,
25,
1066
],
[
1066,
... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
],
... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine and Hepatitis A Vaccine may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Sufent... |
DB00313 | DB00736 | 556 | 660 | [
"DDInter1913",
"DDInter676"
] | Valproic acid | Esomeprazole | Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investig... | Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory... | Minor | 0 | [
[
[
556,
23,
660
]
],
[
[
556,
6,
8374
],
[
8374,
45,
660
]
],
[
[
556,
21,
28785
],
[
28785,
60,
660
]
],
[
[
556,
62,
168
],
[
168,
... | [
[
[
"Valproic acid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Esomeprazole"
]
],
[
[
"Valproic acid",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compo... | Valproic acid (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Esomeprazole (Compound)
Valproic acid (Compound) causes Muscle spasms (Side Effect) and Muscle spasms (Side Effect) is caused by Esomeprazole (Compound)
Valproic acid may cause a minor interaction that can limit clinical effects when taken with ... |
DB06674 | DB10343 | 908 | 962 | [
"DDInter837",
"DDInter160"
] | Golimumab | Bacillus calmette-guerin substrain tice live antigen | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Bacillus calmette-guerin substrain tice live antigen is a vaccine containing attenuated live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of *Mycobacterium bovis* for percutaneous use. It is administered to prevent the development of tuberculosis. | Major | 2 | [
[
[
908,
25,
962
]
],
[
[
908,
64,
617
],
[
617,
24,
962
]
],
[
[
908,
64,
1057
],
[
1057,
25,
962
]
],
[
[
908,
25,
270
],
[
270,
6... | [
[
[
"Golimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bacillus calmette-guerin substrain tice live antigen"
]
],
[
[
"Golimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Budesonide"
]... | Golimumab may lead to a major life threatening interaction when taken with Budesonide and Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Bacillus calmette-guerin substrain tice live antigen
Golimumab may lead to a major life threatening interaction when taken with Etanercept ... |
DB00675 | DB00818 | 888 | 898 | [
"DDInter1744",
"DDInter1538"
] | Tamoxifen | Propofol | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associate... | Moderate | 1 | [
[
[
888,
24,
898
]
],
[
[
888,
6,
7603
],
[
7603,
45,
898
]
],
[
[
888,
21,
28785
],
[
28785,
60,
898
]
],
[
[
888,
23,
112
],
[
112,
... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propofol"
]
],
[
[
"Tamoxifen",
"{u} (Compound) binds {v} (Gene)",
"CYP2B6"
],
[
"CYP2B6",
"{u} (Gene) is bound by {v} (Compound)",
... | Tamoxifen (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Propofol (Compound)
Tamoxifen (Compound) causes Muscle spasms (Side Effect) and Muscle spasms (Side Effect) is caused by Propofol (Compound)
Tamoxifen may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Me... |
DB00757 | DB09020 | 1,166 | 28 | [
"DDInter581",
"DDInter212"
] | Dolasetron | Bisacodyl | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
1166,
24,
28
]
],
[
[
1166,
7,
6952
],
[
6952,
46,
28
]
],
[
[
1166,
21,
28809
],
[
28809,
60,
28
]
],
[
[
1166,
25,
739
],
[
739,
... | [
[
[
"Dolasetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Dolasetron",
"{u} (Compound) upregulates {v} (Gene)",
"MCOLN1"
],
[
"MCOLN1",
"{u} (Gene) is upregulated by {v} (... | Dolasetron (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Bisacodyl (Compound)
Dolasetron (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Bisacodyl (Compound)
Dolasetron may lead to a major life threatening interaction when taken with Lomefloxacin and Lomeflo... |
DB09118 | DB09280 | 1,580 | 1,604 | [
"DDInter1711",
"DDInter1101"
] | Stiripentol | Lumacaftor | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Major | 2 | [
[
[
1580,
25,
1604
]
],
[
[
1580,
63,
379
],
[
379,
24,
1604
]
],
[
[
1580,
64,
477
],
[
477,
24,
1604
]
],
[
[
1580,
24,
985
],
[
985,
... | [
[
[
"Stiripentol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lumacaftor"
]
],
[
[
"Stiripentol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rabeprazole"
],
[
"Rabepra... | Stiripentol may cause a moderate interaction that could exacerbate diseases when taken with Rabeprazole and Rabeprazole may cause a moderate interaction that could exacerbate diseases when taken with Lumacaftor
Stiripentol may lead to a major life threatening interaction when taken with Cilostazol and Cilostazol may ca... |
DB00863 | DB11732 | 1,194 | 1,097 | [
"DDInter1568",
"DDInter1027"
] | Ranitidine | Lasmiditan | Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as [cimetidine] and [famotidine]. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.[A176759,L10818]... | Lasmiditan is an oral medication used in the termination of migraine headaches that was first approved for use in the United States in October 2019.[L9338,L9356] It was also approved by the European Commission on August 17, 2022. Traditionally, the triptan class of anti-migraine medications (e.g. [sumatriptan]) have se... | Moderate | 1 | [
[
[
1194,
24,
1097
]
],
[
[
1194,
24,
478
],
[
478,
24,
1097
]
],
[
[
1194,
25,
1250
],
[
1250,
24,
1097
]
],
[
[
1194,
40,
1127
],
[
1127... | [
[
[
"Ranitidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lasmiditan"
]
],
[
[
"Ranitidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
... | Ranitidine may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Lasmiditan
Ranitidine may lead to a major life threatening interaction when taken with Pazopanib and Pazopanib may cause a mo... |
DB00074 | DB10315 | 1,309 | 1,137 | [
"DDInter166",
"DDInter1127"
] | Basiliximab | Measles virus vaccine live attenuated | A recombinant chimeric (murine/human) monoclonal antibody (IgG1k) that functions as an immunosuppressive agent, specifically binding to and blocking the interleukin-2 receptor a-chain (IL-2R alpha, also known as CD25 antigen) on the surface of activated T-lymphocytes. It is a 144 kDa glycoprotein obtained from fermenta... | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
1309,
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],
[
[
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[
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[
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[
1184,
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],
[
[
1309,
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],
[
1064... | [
[
[
"Basiliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Basiliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Infliximab"
],
[
... | Basiliximab may lead to a major life threatening interaction when taken with Infliximab and Infliximab may lead to a major life threatening interaction when taken with Measles virus vaccine live attenuated
Basiliximab may cause a moderate interaction that could exacerbate diseases when taken with Anakinra and Anakinra ... |
DB00106 | DB01611 | 618 | 1,487 | [
"DDInter4",
"DDInter893"
] | Abarelix | Hydroxychloroquine | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Moderate | 1 | [
[
[
618,
24,
1487
]
],
[
[
618,
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],
[
1520,
25,
1487
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],
[
[
618,
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],
[
1247,
23,
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]
],
[
[
618,
24,
286
],
[
286,
... | [
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
],
... | Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Primaquine and Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Abarelix may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxaz... |
DB09083 | DB12141 | 880 | 971 | [
"DDInter996",
"DDInter817"
] | Ivabradine | Gilteritinib | Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus r... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Major | 2 | [
[
[
880,
25,
971
]
],
[
[
880,
64,
485
],
[
485,
24,
971
]
],
[
[
880,
25,
823
],
[
823,
63,
971
]
],
[
[
880,
63,
597
],
[
597,
24,... | [
[
[
"Ivabradine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gilteritinib"
]
],
[
[
"Ivabradine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pentamidine"
],
[
"Pentamidine",
"{... | Ivabradine may lead to a major life threatening interaction when taken with Pentamidine and Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib
Ivabradine may lead to a major life threatening interaction when taken with Triclabendazole and Triclabendazole may cause a... |
DB00501 | DB01065 | 752 | 43 | [
"DDInter380",
"DDInter1142"
] | Cimetidine | Melatonin | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Melatonin is a biogenic amine that is found in animals, plants and microbes. Aaron B. Lerner of Yale University is credited for naming the hormone and for defining its chemical structure in 1958. In mammals, melatonin is produced by the pineal gland. The pineal gland is small endocrine gland, about the size of a rice g... | Minor | 0 | [
[
[
752,
23,
43
]
],
[
[
752,
62,
598
],
[
598,
1,
43
]
],
[
[
752,
63,
767
],
[
767,
1,
43
]
],
[
[
752,
6,
6017
],
[
6017,
45,
... | [
[
[
"Cimetidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Melatonin"
]
],
[
[
"Cimetidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Nabumetone"
],
[
"... | Cimetidine may cause a minor interaction that can limit clinical effects when taken with Nabumetone and Nabumetone (Compound) resembles Melatonin (Compound)
Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Zolmitriptan and Zolmitriptan (Compound) resembles Melatonin (Compound)
... |
DB00106 | DB00647 | 618 | 675 | [
"DDInter4",
"DDInter528"
] | Abarelix | Dextropropoxyphene | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Moderate | 1 | [
[
[
618,
24,
675
]
],
[
[
618,
24,
888
],
[
888,
64,
675
]
],
[
[
618,
25,
494
],
[
494,
1,
675
]
],
[
[
618,
24,
543
],
[
543,
63,
... | [
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextropropoxyphene"
]
],
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tamoxifen"
],
[... | Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen may lead to a major life threatening interaction when taken with Dextropropoxyphene
Abarelix may lead to a major life threatening interaction when taken with Disopyramide and Disopyramide (Compound) resemble... |
DB00206 | DB00372 | 1,245 | 999 | [
"DDInter1582",
"DDInter1793"
] | Reserpine | Thiethylperazine | An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a rese... | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Moderate | 1 | [
[
[
1245,
24,
999
]
],
[
[
1245,
24,
1614
],
[
1614,
63,
999
]
],
[
[
1245,
24,
245
],
[
245,
24,
999
]
],
[
[
1245,
63,
176
],
[
176,
... | [
[
[
"Reserpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thiethylperazine"
]
],
[
[
"Reserpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
],
[
... | Reserpine may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine
Reserpine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glime... |
DB00635 | DB14783 | 1,573 | 287 | [
"DDInter1515",
"DDInter574"
] | Prednisone | Diroximel fumarate | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
1573,
24,
287
]
],
[
[
1573,
63,
1101
],
[
1101,
24,
287
]
],
[
[
1573,
24,
384
],
[
384,
24,
287
]
],
[
[
1573,
1,
1220
],
[
1220,
... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
... | Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib an... |
DB00023 | DB00323 | 305 | 1,062 | [
"DDInter127",
"DDInter1829"
] | Asparaginase Escherichia coli | Tolcapone | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Tolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase (COMT). It is used in the treatment of Parkinson's disease as an adjunct to levodopa/carbidopa medication. It is a yellow, odorless, non-hygroscopic, crystalline compound. Tolcapone is associated with a risk of hepatotoxicity. | Moderate | 1 | [
[
[
305,
24,
1062
]
],
[
[
305,
24,
24
],
[
24,
1,
1062
]
],
[
[
305,
24,
126
],
[
126,
62,
1062
]
],
[
[
305,
24,
850
],
[
850,
63,... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolcapone"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Tolmetin and Tolmetin (Compound) resembles Tolcapone (Compound)
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a mi... |
DB06168 | DB08895 | 1,531 | 976 | [
"DDInter281",
"DDInter1825"
] | Canakinumab | Tofacitinib | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
1531,
25,
976
]
],
[
[
1531,
23,
1193
],
[
1193,
62,
976
]
],
[
[
1531,
62,
1461
],
[
1461,
23,
976
]
],
[
[
1531,
24,
200
],
[
200,
... | [
[
[
"Canakinumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Canakinumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Zinc ... | Canakinumab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Tofacitinib
Canakinumab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vi... |
DB00771 | DB01100 | 262 | 1,568 | [
"DDInter397",
"DDInter1470"
] | Clidinium | Pimozide | Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. It inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. It is used for the tr... | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Moderate | 1 | [
[
[
262,
24,
1568
]
],
[
[
262,
40,
1413
],
[
1413,
40,
1568
]
],
[
[
262,
63,
19
],
[
19,
24,
1568
]
],
[
[
262,
24,
830
],
[
830,
... | [
[
[
"Clidinium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pimozide"
]
],
[
[
"Clidinium",
"{u} (Compound) resembles {v} (Compound)",
"Fexofenadine"
],
[
"Fexofenadine",
"{u} (Compound) resemble... | Clidinium (Compound) resembles Fexofenadine (Compound) and Fexofenadine (Compound) resembles Pimozide (Compound)
Clidinium may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Pimozide
... |
DB09061 | DB11186 | 1,627 | 1,609 | [
"DDInter284",
"DDInter1427"
] | Cannabidiol | Pentoxyverine | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
1627,
24,
1609
]
],
[
[
1627,
63,
104
],
[
104,
24,
1609
]
],
[
[
1627,
24,
407
],
[
407,
24,
1609
]
],
[
[
1627,
63,
104
],
[
104,
... | [
[
[
"Cannabidiol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Cannabidiol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
... | Cannabidiol may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Cannabidiol may cause a moderate interaction that could exacerbate diseases when taken with Opium and Op... |
DB11793 | DB11796 | 738 | 1,612 | [
"DDInter1297",
"DDInter786"
] | Niraparib | Fostemsavir | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor. It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir prevents the first step in the... | Moderate | 1 | [
[
[
738,
24,
1612
]
],
[
[
738,
63,
1101
],
[
1101,
23,
1612
]
],
[
[
738,
24,
1017
],
[
1017,
62,
1612
]
],
[
[
738,
63,
1424
],
[
1424,
... | [
[
[
"Niraparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
]
],
[
[
"Niraparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Fostemsavir
Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatini... |
DB00496 | DB00771 | 194 | 262 | [
"DDInter480",
"DDInter397"
] | Darifenacin | Clidinium | Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence. Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it should not be used in people with urinary retention. It is unknown if M3 receptor ... | Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. It inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. It is used for the tr... | Moderate | 1 | [
[
[
194,
35,
262
]
],
[
[
194,
24,
1511
],
[
1511,
63,
262
]
],
[
[
194,
40,
1688
],
[
1688,
1,
262
]
],
[
[
194,
40,
704
],
[
704,
... | [
[
[
"Darifenacin",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clidinium"
]
],
[
[
"Darifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken ... | Darifenacin (Compound) resembles Clidinium (Compound) and
Darifenacin may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Clidinium
Darifenacin (Compound) resembles Diphenoxylate (Comp... |
DB00108 | DB01168 | 1,066 | 1,053 | [
"DDInter1268",
"DDInter1526"
] | Natalizumab | Procarbazine | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Major | 2 | [
[
[
1066,
25,
1053
]
],
[
[
1066,
24,
496
],
[
496,
63,
1053
]
],
[
[
1066,
64,
1648
],
[
1648,
24,
1053
]
],
[
[
1066,
25,
1683
],
[
1683... | [
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Procarbazine"
]
],
[
[
"Natalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
],
[
... | Natalizumab may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine and Hepatitis A Vaccine may cause a moderate interaction that could exacerbate diseases when taken with Procarbazine
Natalizumab may lead to a major life threatening interaction when taken with Aldesleukin an... |
DB01073 | DB01229 | 1,488 | 973 | [
"DDInter745",
"DDInter1377"
] | Fludarabine | Paclitaxel | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Moderate | 1 | [
[
[
1488,
24,
973
]
],
[
[
1488,
24,
310
],
[
310,
63,
973
]
],
[
[
1488,
21,
28643
],
[
28643,
60,
973
]
],
[
[
1488,
23,
945
],
[
945,
... | [
[
[
"Fludarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Fludarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[... | Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Fludarabine (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Paclitaxel (Co... |
DB00671 | DB01172 | 778 | 416 | [
"DDInter319",
"DDInter1004"
] | Cefixime | Kanamycin | Bacteria possess a cell wall comprising a glycopeptide polymer commonly known as peptidoglycan, which is synthesized and remodelled through the action of a family of enzymes known as "penicillin-binding proteins" (PBPs). β-lactam antibiotics, including cephalosporins, are PBP inhibitors that, through inhibition of esse... | Kanamycin (also known as kanamycin A) is an aminoglycoside bacteriocidal antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections. Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. | Moderate | 1 | [
[
[
778,
24,
416
]
],
[
[
778,
21,
28680
],
[
28680,
60,
416
]
],
[
[
778,
1,
164
],
[
164,
24,
416
]
],
[
[
778,
1,
1024
],
[
1024,
... | [
[
[
"Cefixime",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Kanamycin"
]
],
[
[
"Cefixime",
"{u} (Compound) causes {v} (Side Effect)",
"Rash"
],
[
"Rash",
"{u} (Side Effect) is caused by {v} (Comp... | Cefixime (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Kanamycin (Compound)
Cefixime (Compound) resembles Cefalotin (Compound) and Cefalotin may cause a moderate interaction that could exacerbate diseases when taken with Kanamycin
Cefixime (Compound) resembles Cefpodoxime (Compound) and Cefpo... |
DB00757 | DB01209 | 1,166 | 1,359 | [
"DDInter581",
"DDInter531"
] | Dolasetron | Dezocine | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Dezocine is a partial opiate drug and is used for pain management. Dezocine is a very effective alternative to fentanyl when administered during outpatient laparoscopy, although is associated with an increased incidence of postoperative nausea. | Moderate | 1 | [
[
[
1166,
24,
1359
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[
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1166,
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234,
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[
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[
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],
[
[
1166,
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],
[
85,
... | [
[
[
"Dolasetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dezocine"
]
],
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pentazocine"
],
[
"Pentazocine... | Dolasetron may lead to a major life threatening interaction when taken with Pentazocine and Pentazocine (Compound) resembles Dezocine (Compound)
Dolasetron may lead to a major life threatening interaction when taken with Palonosetron and Palonosetron may cause a moderate interaction that could exacerbate diseases when ... |
DB05679 | DB11714 | 1,683 | 1,316 | [
"DDInter1907",
"DDInter610"
] | Ustekinumab | Durvalumab | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Durvalumab is a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody and a novel immune-checkpoint inhibitor for cancer treatment. Produced by recombinant DNA technology in Chinese Hamster Ovary (CHO) cell suspension culture, durvalumab is a programmed death-ligand 1 (PD-L1) blocking antibody that works to promote... | Moderate | 1 | [
[
[
1683,
24,
1316
]
],
[
[
1683,
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],
[
1461,
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]
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[
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],
[
1114,
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]
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[
[
1683,
63,
167
],
[
167... | [
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Durvalumab"
]
],
[
[
"Ustekinumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
... | Ustekinumab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Durvalumab
Ustekinumab may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfa... |
DB09074 | DB11767 | 1,362 | 1,583 | [
"DDInter1327",
"DDInter1643"
] | Olaparib | Sarilumab | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approve... | Moderate | 1 | [
[
[
1362,
24,
1583
]
],
[
[
1362,
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],
[
1186,
24,
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[
[
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64,
362
],
[
362,
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],
[
[
1362,
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287
],
[
287,
... | [
[
[
"Olaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarilumab"
]
],
[
[
"Olaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Radium Ra 223 dichloride"
],... | Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Radium Ra 223 dichloride and Radium Ra 223 dichloride may cause a moderate interaction that could exacerbate diseases when taken with Sarilumab
Olaparib may lead to a major life threatening interaction when taken with Phenytoin and... |
DB00647 | DB01254 | 675 | 1,213 | [
"DDInter528",
"DDInter484"
] | Dextropropoxyphene | Dasatinib | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
675,
24,
1213
]
],
[
[
675,
6,
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],
[
8374,
45,
1213
]
],
[
[
675,
7,
11074
],
[
11074,
46,
1213
]
],
[
[
675,
18,
3023
],
[
3023,
... | [
[
[
"Dextropropoxyphene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Dextropropoxyphene",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {... | Dextropropoxyphene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dasatinib (Compound)
Dextropropoxyphene (Compound) upregulates HERC6 (Gene) and HERC6 (Gene) is upregulated by Dasatinib (Compound)
Dextropropoxyphene (Compound) downregulates RUVBL1 (Gene) and RUVBL1 (Gene) is downregulated by Dasatinib (C... |
DB09080 | DB12141 | 144 | 971 | [
"DDInter1331",
"DDInter817"
] | Olodaterol | Gilteritinib | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
144,
24,
971
]
],
[
[
144,
62,
1247
],
[
1247,
23,
971
]
],
[
[
144,
63,
485
],
[
485,
24,
971
]
],
[
[
144,
24,
730
],
[
730,
6... | [
[
[
"Olodaterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Olodaterol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Olodaterol may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Olodaterol may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine... |
DB00163 | DB06779 | 1,461 | 365 | [
"DDInter1943",
"DDInter470"
] | Vitamin E | Dalteparin | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Moderate | 1 | [
[
[
1461,
24,
365
]
],
[
[
1461,
24,
298
],
[
298,
63,
365
]
],
[
[
1461,
24,
1018
],
[
1018,
25,
365
]
],
[
[
1461,
24,
397
],
[
397,
... | [
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dalteparin"
]
],
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Protein C"
],
[
... | Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Protein C and Protein C may cause a moderate interaction that could exacerbate diseases when taken with Dalteparin
Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Ticlopidine and Ticlopidi... |
DB00514 | DB01576 | 506 | 93 | [
"DDInter527",
"DDInter526"
] | Dextromethorphan | Dextroamphetamine | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Dextroamphetamine is the dextrorotatory enantiomer of amphetamine. Dextroamphetamine was approved by the FDA in 2001 for the treatment of attention deficit hyperactivity disorder[L6010,Label]. | Moderate | 1 | [
[
[
506,
24,
93
]
],
[
[
506,
63,
73
],
[
73,
1,
93
]
],
[
[
506,
63,
80
],
[
80,
40,
93
]
],
[
[
506,
24,
94
],
[
94,
1,
93
... | [
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextroamphetamine"
]
],
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenterm... | Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Phentermine and Phentermine (Compound) resembles Dextroamphetamine (Compound)
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Amphetamine and Amphetamine (Compound) resembles... |
DB09075 | DB12267 | 498 | 1,476 | [
"DDInter621",
"DDInter233"
] | Edoxaban | Brigatinib | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
498,
24,
1476
]
],
[
[
498,
64,
79
],
[
79,
24,
1476
]
],
[
[
498,
24,
1456
],
[
1456,
24,
1476
]
],
[
[
498,
25,
1598
],
[
1598,
... | [
[
[
"Edoxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Edoxaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sorafenib"
],
[
"Sorafenib",
... | Edoxaban may lead to a major life threatening interaction when taken with Sorafenib and Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib
Edoxaban may cause a moderate interaction that could exacerbate diseases when taken with Venetoclax and Venetoclax may cause a mode... |
DB00208 | DB09079 | 1,018 | 1,496 | [
"DDInter1804",
"DDInter1296"
] | Ticlopidine | Nintedanib | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Nintedanib is a small molecule kinase inhibitor used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC).[L8453,L8459] It was first approved for use in the United States in 2014. Within the spectrum of idiopathic pulmonary fibrosis trea... | Moderate | 1 | [
[
[
1018,
24,
1496
]
],
[
[
1018,
25,
707
],
[
707,
24,
1496
]
],
[
[
1018,
63,
20
],
[
20,
24,
1496
]
],
[
[
1018,
24,
1412
],
[
1412,
... | [
[
[
"Ticlopidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nintedanib"
]
],
[
[
"Ticlopidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Danaparoid"
],
[
"Danaparo... | Ticlopidine may lead to a major life threatening interaction when taken with Danaparoid and Danaparoid may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib
Ticlopidine may cause a moderate interaction that could exacerbate diseases when taken with Tenecteplase and Tenecteplase may ... |
DB00381 | DB00619 | 376 | 1,419 | [
"DDInter79",
"DDInter909"
] | Amlodipine | Imatinib | Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial... | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Moderate | 1 | [
[
[
376,
24,
1419
]
],
[
[
376,
6,
4973
],
[
4973,
45,
1419
]
],
[
[
376,
18,
5527
],
[
5527,
57,
1419
]
],
[
[
376,
7,
6448
],
[
6448,
... | [
[
[
"Amlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
]
],
[
[
"Amlodipine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Amlodipine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Imatinib (Compound)
Amlodipine (Compound) downregulates HAT1 (Gene) and HAT1 (Gene) is downregulated by Imatinib (Compound)
Amlodipine (Compound) upregulates CTSD (Gene) and CTSD (Gene) is downregulated by Imatinib (Compound)
Amlodipine (Compound) ca... |
DB00816 | DB11901 | 1,674 | 913 | [
"DDInter1346",
"DDInter107"
] | Orciprenaline | Apalutamide | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
1674,
24,
913
]
],
[
[
1674,
63,
600
],
[
600,
24,
913
]
],
[
[
1674,
24,
1237
],
[
1237,
24,
913
]
],
[
[
1674,
25,
877
],
[
877,
... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
],
... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine... |
DB00086 | DB01105 | 1,167 | 222 | [
"DDInter1712",
"DDInter1665"
] | Streptokinase | Sibutramine | Streptokinase, is a sterile, purified preparation of a bacterial protein elaborated by group C (beta) -hemolytic streptococci. | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
1167,
24,
222
]
],
[
[
1167,
25,
1046
],
[
1046,
63,
222
]
],
[
[
1167,
24,
1027
],
[
1027,
24,
222
]
],
[
[
1167,
64,
1432
],
[
1432,... | [
[
[
"Streptokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Streptokinase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Caplacizumab"
],
[
"C... | Streptokinase may lead to a major life threatening interaction when taken with Caplacizumab and Caplacizumab may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine
Streptokinase may cause a moderate interaction that could exacerbate diseases when taken with Piroxicam and Piroxicam m... |
DB00176 | DB01142 | 529 | 1,264 | [
"DDInter770",
"DDInter593"
] | Fluvoxamine | Doxepin | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Major | 2 | [
[
[
529,
25,
1264
]
],
[
[
529,
24,
401
],
[
401,
24,
1264
]
],
[
[
529,
24,
649
],
[
649,
63,
1264
]
],
[
[
529,
6,
4973
],
[
4973,
... | [
[
[
"Fluvoxamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Doxepin"
]
],
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
"Promethaz... | Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clo... |
DB06207 | DB09054 | 910 | 384 | [
"DDInter1667",
"DDInter905"
] | Silodosin | Idelalisib | Silodosin is a selective antagonist of alpha(α)-1 adrenergic receptors that binds to the α<sub>1A</sub> subtype with the highest affinity. α1-adrenergic receptors regulate smooth muscle tone in the bladder neck, prostate, and prostatic urethra: the α<sub>1A</sub> subtype accounts for approximately 75% of α1-adrenocepto... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Major | 2 | [
[
[
910,
25,
384
]
],
[
[
910,
24,
1618
],
[
1618,
24,
384
]
],
[
[
910,
63,
600
],
[
600,
24,
384
]
],
[
[
910,
24,
1619
],
[
1619,
... | [
[
[
"Silodosin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idelalisib"
]
],
[
[
"Silodosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabozantinib"
],
[
"Cabozantin... | Silodosin may cause a moderate interaction that could exacerbate diseases when taken with Cabozantinib and Cabozantinib may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Silodosin may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Flu... |
DB00364 | DB01208 | 417 | 945 | [
"DDInter1717",
"DDInter1705"
] | Sucralfate | Sparfloxacin | Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia. It is considered a _cytoprotective agent_, protect... | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Moderate | 1 | [
[
[
417,
24,
945
]
],
[
[
417,
24,
739
],
[
739,
1,
945
]
],
[
[
417,
63,
1176
],
[
1176,
1,
945
]
],
[
[
417,
21,
29707
],
[
29707,
... | [
[
[
"Sucralfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sparfloxacin"
]
],
[
[
"Sucralfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomefloxacin"
],
... | Sucralfate may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Sparfloxacin (Compound)
Sucralfate may cause a moderate interaction that could exacerbate diseases when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Sparfloxacin... |
DB00650 | DB01212 | 1,147 | 1,453 | [
"DDInter1041",
"DDInter334"
] | Leucovorin | Ceftriaxone | Folinic Acid (also known as 5-formyl tetrahydrofolic acid or leucovorin) is the 5-formyl derivative of tetrahydrofolic acid, a necessary co-factor in the body. Commercially available leucovorin is composed of a 1:1 racemic mixture of the dextrorotary and levorotary isomers, while levoleucovorin contains only the pharma... | Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic. It has a very long half-life compared to other cephalosporins and is high penetrable into the meninges, eyes, and inner ear. Ceftriaxone has broader and stronger gram-negative coverage then first or second-generation cephalosporins, but worse ac... | Major | 2 | [
[
[
1147,
25,
1453
]
],
[
[
1147,
21,
28987
],
[
28987,
60,
1453
]
],
[
[
1147,
21,
28987
],
[
28987,
60,
1024
],
[
1024,
40,
1453
]
],
[
[
... | [
[
[
"Leucovorin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ceftriaxone"
]
],
[
[
"Leucovorin",
"{u} (Compound) causes {v} (Side Effect)",
"Chills"
],
[
"Chills",
"{u} (Side Effect) is caused by {v} (Compound)... | Leucovorin (Compound) causes Chills (Side Effect) and Chills (Side Effect) is caused by Ceftriaxone (Compound)
Leucovorin (Compound) causes Chills (Side Effect) and Chills (Side Effect) is caused by Cefpodoxime (Compound) and Cefpodoxime (Compound) resembles Ceftriaxone (Compound)
Leucovorin (Compound) causes Abdominal... |
DB00250 | DB00515 | 10 | 589 | [
"DDInter475",
"DDInter387"
] | Dapsone | Cisplatin | A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of m... | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Moderate | 1 | [
[
[
10,
24,
589
]
],
[
[
10,
6,
7720
],
[
7720,
45,
589
]
],
[
[
10,
21,
29118
],
[
29118,
60,
589
]
],
[
[
10,
24,
839
],
[
839,
23... | [
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cisplatin"
]
],
[
[
"Dapsone",
"{u} (Compound) binds {v} (Gene)",
"PTGS2"
],
[
"PTGS2",
"{u} (Gene) is bound by {v} (Compound)",
"C... | Dapsone (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Cisplatin (Compound)
Dapsone (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Cisplatin (Compound)
Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Grepafloxacin and Grepafloxa... |
DB00197 | DB00999 | 1,324 | 504 | [
"DDInter1881",
"DDInter883"
] | Troglitazone | Hydrochlorothiazide | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Moderate | 1 | [
[
[
1324,
24,
504
]
],
[
[
1324,
24,
1326
],
[
1326,
40,
504
]
],
[
[
1324,
24,
178
],
[
178,
1,
504
]
],
[
[
1324,
24,
126
],
[
126,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrochlorothiazide"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenamide"... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Diclofenamide and Diclofenamide (Compound) resembles Hydrochlorothiazide (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Polythiazide and Polythiazide (Compound) resembles... |
DB00041 | DB00790 | 1,648 | 664 | [
"DDInter38",
"DDInter1431"
] | Aldesleukin | Perindopril | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible fo... | Moderate | 1 | [
[
[
1648,
24,
664
]
],
[
[
1648,
24,
1638
],
[
1638,
1,
664
]
],
[
[
1648,
24,
954
],
[
954,
40,
664
]
],
[
[
1648,
24,
885
],
[
885,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perindopril"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trandolapril"
],
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril and Trandolapril (Compound) resembles Perindopril (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril (Compound) resembles Perindopril (Comp... |
DB00831 | DB06176 | 1,178 | 1,342 | [
"DDInter1866",
"DDInter1616"
] | Trifluoperazine | Romidepsin | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Moderate | 1 | [
[
[
1178,
24,
1342
]
],
[
[
1178,
23,
112
],
[
112,
23,
1342
]
],
[
[
1178,
63,
485
],
[
485,
24,
1342
]
],
[
[
1178,
24,
1520
],
[
1520,
... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romidepsin"
]
],
[
[
"Trifluoperazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
... | Trifluoperazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Romidepsin
Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Pentamidi... |
DB01246 | DB05812 | 820 | 1,374 | [
"DDInter45",
"DDInter8"
] | Alimemazine | Abiraterone | A phenothiazine derivative that is used as an antipruritic. | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
820,
24,
1374
]
],
[
[
820,
6,
8374
],
[
8374,
45,
1374
]
],
[
[
820,
21,
29113
],
[
29113,
60,
1374
]
],
[
[
820,
62,
112
],
[
112,
... | [
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Alimemazine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Alimemazine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Abiraterone (Compound)
Alimemazine (Compound) causes Hypokalaemia (Side Effect) and Hypokalaemia (Side Effect) is caused by Abiraterone (Compound)
Alimemazine may cause a minor interaction that can limit clinical effects when taken with Metronidaz... |
DB01110 | DB06414 | 86 | 655 | [
"DDInter1209",
"DDInter703"
] | Miconazole | Etravirine | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Moderate | 1 | [
[
[
86,
24,
655
]
],
[
[
86,
6,
4973
],
[
4973,
45,
655
]
],
[
[
86,
21,
28680
],
[
28680,
60,
655
]
],
[
[
86,
62,
1101
],
[
1101,
... | [
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
]
],
[
[
"Miconazole",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Miconazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Etravirine (Compound)
Miconazole (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Etravirine (Compound)
Miconazole may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexarotene may cau... |
DB00146 | DB01320 | 160 | 651 | [
"DDInter265",
"DDInter783"
] | Calcifediol | Fosphenytoin | The major circulating metabolite of vitamin D3 (cholecalciferol). It is produced in the liver and is the best indicator of the body's vitamin D stores. It is effective in the treatment of rickets and osteomalacia, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties. | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Moderate | 1 | [
[
[
160,
24,
651
]
],
[
[
160,
24,
362
],
[
362,
1,
651
]
],
[
[
160,
25,
1041
],
[
1041,
24,
651
]
],
[
[
160,
24,
417
],
[
417,
24... | [
[
[
"Calcifediol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Calcifediol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
[... | Calcifediol may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Compound)
Calcifediol may lead to a major life threatening interaction when taken with Paricalcitol and Paricalcitol may cause a moderate interaction that could exacerba... |
DB05239 | DB14409 | 866 | 1,129 | [
"DDInter425",
"DDInter867"
] | Cobimetinib | Human adenovirus e serotype 4 strain cl-68578 antigen | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
866,
24,
1129
]
],
[
[
866,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
866,
24,
1683
],
[
1683,
24,
1129
]
],
[
[
866,
63,
372
],
[
372,
... | [
[
[
"Cobimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Cobimetinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Cobimetinib may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Cobimetinib may cause a moderate interaction that could exacerbate diseases when ta... |
DB04932 | DB14276 | 1,564 | 1,631 | [
"DDInter491",
"DDInter1892"
] | Defibrotide | Turmeric | Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Da... | Turmeric is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. | Minor | 0 | [
[
[
1564,
23,
1631
]
],
[
[
1564,
64,
20
],
[
20,
23,
1631
]
],
[
[
1564,
25,
1046
],
[
1046,
23,
1631
]
],
[
[
1564,
64,
20
],
[
20,
... | [
[
[
"Defibrotide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Turmeric"
]
],
[
[
"Defibrotide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tenecteplase"
],
[
"Tenectepla... | Defibrotide may lead to a major life threatening interaction when taken with Tenecteplase and Tenecteplase may cause a minor interaction that can limit clinical effects when taken with Turmeric
Defibrotide may lead to a major life threatening interaction when taken with Caplacizumab and Caplacizumab may cause a minor i... |
DB00748 | DB04948 | 662 | 1,084 | [
"DDInter297",
"DDInter1083"
] | Carbinoxamine | Lofexidine | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hyp... | Moderate | 1 | [
[
[
662,
24,
1084
]
],
[
[
662,
24,
1617
],
[
1617,
1,
1084
]
],
[
[
662,
63,
1020
],
[
1020,
1,
1084
]
],
[
[
662,
24,
1311
],
[
1311,
... | [
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lofexidine"
]
],
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apraclonidine"
],... | Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Apraclonidine and Apraclonidine (Compound) resembles Lofexidine (Compound)
Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Clonidine and Clonidine (Compound) resembles Lofexidine (... |
DB00915 | DB01069 | 1,170 | 401 | [
"DDInter60",
"DDInter1533"
] | Amantadine | Promethazine | An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesi... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
1170,
24,
401
]
],
[
[
1170,
24,
1264
],
[
1264,
63,
401
]
],
[
[
1170,
63,
104
],
[
104,
24,
401
]
],
[
[
1170,
6,
2250
],
[
2250,
... | [
[
[
"Amantadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Amantadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Amantadine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Amantadine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdila... |
DB00529 | DB01099 | 789 | 1,272 | [
"DDInter779",
"DDInter744"
] | Foscarnet | Flucytosine | An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV. | A fluorinated cytosine analog that is used as an antifungal agent. | Moderate | 1 | [
[
[
789,
24,
1272
]
],
[
[
789,
21,
29209
],
[
29209,
60,
1272
]
],
[
[
789,
25,
485
],
[
485,
24,
1272
]
],
[
[
789,
24,
50
],
[
50,
... | [
[
[
"Foscarnet",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flucytosine"
]
],
[
[
"Foscarnet",
"{u} (Compound) causes {v} (Side Effect)",
"Anorexia"
],
[
"Anorexia",
"{u} (Side Effect) is caused ... | Foscarnet (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Flucytosine (Compound)
Foscarnet may lead to a major life threatening interaction when taken with Pentamidine and Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Flucytosine
Foscarnet m... |
DB00008 | DB05679 | 491 | 1,683 | [
"DDInter1407",
"DDInter1907"
] | Peginterferon alfa-2a | Ustekinumab | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Moderate | 1 | [
[
[
491,
24,
1683
]
],
[
[
491,
24,
1362
],
[
1362,
63,
1683
]
],
[
[
491,
24,
305
],
[
305,
24,
1683
]
],
[
[
491,
25,
1101
],
[
1101,
... | [
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]
],
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olap... | Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab
Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with As... |
DB00960 | DB09340 | 887 | 1,013 | [
"DDInter1471",
"DDInter1895"
] | Pindolol | Tyropanoic acid | Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the earl... | Tyropanoic acid is a radiocontrast agent used in cholecystography, the X-ray diagnosis of gallstones under the trade names include Bilopaque, Lumopaque, Tyropaque, and Bilopac. The molecule contains three heavy iodine atoms which obstruct X-rays in the same way as the calcium in bones, which results in a visible image ... | Moderate | 1 | [
[
[
887,
24,
1013
]
],
[
[
887,
24,
777
],
[
777,
24,
1013
]
],
[
[
887,
1,
819
],
[
819,
24,
1013
]
],
[
[
887,
40,
726
],
[
726,
2... | [
[
[
"Pindolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tyropanoic acid"
]
],
[
[
"Pindolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopromide"
],
[
... | Pindolol may cause a moderate interaction that could exacerbate diseases when taken with Iopromide and Iopromide may cause a moderate interaction that could exacerbate diseases when taken with Tyropanoic acid
Pindolol (Compound) resembles Acebutolol (Compound) and Acebutolol may cause a moderate interaction that could ... |
DB00975 | DB06228 | 1,317 | 792 | [
"DDInter573",
"DDInter1609"
] | Dipyridamole | Rivaroxaban | A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752) | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Major | 2 | [
[
[
1317,
25,
792
]
],
[
[
1317,
6,
4973
],
[
4973,
45,
792
]
],
[
[
1317,
7,
2384
],
[
2384,
46,
792
]
],
[
[
1317,
21,
28703
],
[
28703,... | [
[
[
"Dipyridamole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Dipyridamole",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Riva... | Dipyridamole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Rivaroxaban (Compound)
Dipyridamole (Compound) upregulates CDK6 (Gene) and CDK6 (Gene) is upregulated by Rivaroxaban (Compound)
Dipyridamole (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Rivaroxaban (Compound)
Dip... |
DB00026 | DB10989 | 1,184 | 496 | [
"DDInter94",
"DDInter858"
] | Anakinra | Hepatitis A Vaccine | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure. Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infectio... | Moderate | 1 | [
[
[
1184,
24,
496
]
],
[
[
1184,
24,
1093
],
[
1093,
63,
496
]
],
[
[
1184,
24,
4
],
[
4,
24,
496
]
],
[
[
1184,
25,
976
],
[
976,
2... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixekizumab"
],
... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Ixekizumab and Ixekizumab may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepe... |
DB00250 | DB00615 | 10 | 690 | [
"DDInter475",
"DDInter1589"
] | Dapsone | Rifabutin | A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of m... | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Moderate | 1 | [
[
[
10,
24,
690
]
],
[
[
10,
24,
463
],
[
463,
1,
690
]
],
[
[
10,
6,
8374
],
[
8374,
45,
690
]
],
[
[
10,
6,
7720
],
[
7720,
46,
... | [
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifabutin"
]
],
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifampicin"
],
[
"Ri... | Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Rifampicin and Rifampicin (Compound) resembles Rifabutin (Compound)
Dapsone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rifabutin (Compound)
Dapsone (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by R... |
DB00741 | DB08820 | 167 | 1,478 | [
"DDInter885",
"DDInter997"
] | Hydrocortisone | Ivacaftor | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
167,
24,
1478
]
],
[
[
167,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
167,
21,
29221
],
[
29221,
60,
1478
]
],
[
[
167,
23,
307
],
[
307,
... | [
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Hydrocortisone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Comp... | Hydrocortisone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Hydrocortisone (Compound) causes Infestation (Side Effect) and Infestation (Side Effect) is caused by Ivacaftor (Compound)
Hydrocortisone may cause a minor interaction that can limit clinical effects when taken with Modafin... |
DB00252 | DB08912 | 362 | 1,040 | [
"DDInter1460",
"DDInter462"
] | Phenytoin | Dabrafenib | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
362,
24,
1040
]
],
[
[
362,
6,
4973
],
[
4973,
45,
1040
]
],
[
[
362,
54,
19201
],
[
19201,
15,
1040
]
],
[
[
362,
18,
6495
],
[
6495,... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Phenytoin",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Phenytoin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dabrafenib (Compound)
Phenytoin (Compound) is included by Cytochrome P450 2C19 Inducers (Pharmacologic Class) and Cytochrome P450 2C19 Inducers (Pharmacologic Class) includes Dabrafenib (Compound)
Phenytoin (Compound) downregulates S100A6 (Gene) and S... |
DB00439 | DB08889 | 289 | 350 | [
"DDInter341",
"DDInter299"
] | Cerivastatin | Carfilzomib | On August 8, 2001 the U.S. Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew Baycol from the U.S. market, due to reports of fatal rhabdomyolysis, a severe adverse reaction from this cholesterol-lowering (lipid-lowering) product. It has also been withdrawn from the Cana... | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Moderate | 1 | [
[
[
289,
24,
350
]
],
[
[
289,
63,
482
],
[
482,
24,
350
]
],
[
[
289,
24,
310
],
[
310,
24,
350
]
],
[
[
289,
24,
148
],
[
148,
63,... | [
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carfilzomib"
]
],
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tioguanine"
],
... | Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine and Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Carfilzomib
Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and ... |
DB08881 | DB09046 | 868 | 1,094 | [
"DDInter1925",
"DDInter1201"
] | Vemurafenib | Metreleptin | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Metreleptin, a recombinant analog of the human hormone leptin, is an orphan drug used to treat complications of leptin deficiency in people with lipodystrophy. Lipodystrophies include a range of disorders characterized by the reduction, absence, or altered distribution of adipose tissue. Complications of lipodystrophy ... | Moderate | 1 | [
[
[
868,
24,
1094
]
],
[
[
868,
25,
230
],
[
230,
62,
1094
]
],
[
[
868,
62,
168
],
[
168,
23,
1094
]
],
[
[
868,
23,
1135
],
[
1135,
... | [
[
[
"Vemurafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metreleptin"
]
],
[
[
"Vemurafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Relugolix"
],
[
"Relugoli... | Vemurafenib may lead to a major life threatening interaction when taken with Relugolix and Relugolix may cause a minor interaction that can limit clinical effects when taken with Metreleptin
Vemurafenib may cause a minor interaction that can limit clinical effects when taken with Bortezomib and Bortezomib may cause a m... |
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