drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00907 | DB08824 | 290 | 591 | [
"DDInter427",
"DDInter959"
] | Cocaine (topical) | Ioflupane I-123 | Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts. | Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes. | Moderate | 1 | [
[
[
290,
35,
591
]
],
[
[
290,
6,
2437
],
[
2437,
45,
591
]
],
[
[
290,
21,
28681
],
[
28681,
60,
591
]
],
[
[
290,
64,
307
],
[
307,
... | [
[
[
"Cocaine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioflupane I-123"
]
],
[
[
"Cocaine",
"{u} (Compound) binds {v} (Gene)",
"SLC6A3"
],
[
"SLC6A3",
... | Cocaine (Compound) resembles Ioflupane I-123 (Compound) and Cocaine may cause a moderate interaction that could exacerbate diseases when taken with Ioflupane I-123
Cocaine (Compound) binds SLC6A3 (Gene) and SLC6A3 (Gene) is bound by Ioflupane I-123 (Compound)
Cocaine (Compound) causes Hypersensitivity (Side Effect) and... |
DB00495 | DB11730 | 139 | 351 | [
"DDInter1961",
"DDInter1588"
] | Zidovudine | Ribociclib | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
139,
24,
351
]
],
[
[
139,
24,
310
],
[
310,
24,
351
]
],
[
[
139,
63,
597
],
[
597,
24,
351
]
],
[
[
139,
25,
1613
],
[
1613,
2... | [
[
[
"Zidovudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Zidovudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib
Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and... |
DB00651 | DB01339 | 746 | 728 | [
"DDInter613",
"DDInter1922"
] | Dyphylline | Vecuronium | Dyphylline is a theophylline derivative with broncho- and vasodilator properties. It is typically used in the management of asthma, cardiac dyspnea, and bronchitis. | Monoquaternary homolog of pancuronium. A non-depolarizing neuromuscular blocking agent with shorter duration of action than pancuronium. Its lack of significant cardiovascular effects and lack of dependence on good kidney function for elimination as well as its short duration of action and easy reversibility provide ad... | Moderate | 1 | [
[
[
746,
24,
728
]
],
[
[
746,
24,
1610
],
[
1610,
1,
728
]
],
[
[
746,
24,
1579
],
[
1579,
40,
728
]
],
[
[
746,
21,
28642
],
[
28642,
... | [
[
[
"Dyphylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vecuronium"
]
],
[
[
"Dyphylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rocuronium"
],
[
... | Dyphylline may cause a moderate interaction that could exacerbate diseases when taken with Rocuronium and Rocuronium (Compound) resembles Vecuronium (Compound)
Dyphylline may cause a moderate interaction that could exacerbate diseases when taken with Pancuronium and Pancuronium (Compound) resembles Vecuronium (Compound... |
DB05273 | DB06650 | 507 | 1,500 | [
"DDInter1638",
"DDInter1324"
] | Samarium (153Sm) lexidronam | Ofatumumab | Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.Samarium ... | Ofatumumab is a novel anti-CD20 monoclonal antibody that targets B-cells. It is an IgG1κ human monoclonal antibody produced from a recombinant murine cell line (NS0) via transgenic mouse and hybridoma technology. Ofatumumab works by recognizing antigens that are expressed on the tumour cells in certain cancers; however... | Major | 2 | [
[
[
507,
25,
1500
]
],
[
[
507,
24,
270
],
[
270,
63,
1500
]
],
[
[
507,
64,
869
],
[
869,
24,
1500
]
],
[
[
507,
63,
248
],
[
248,
... | [
[
[
"Samarium (153Sm) lexidronam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ofatumumab"
]
],
[
[
"Samarium (153Sm) lexidronam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizu... | Samarium (153Sm) lexidronam may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab and Ocrelizumab may cause a moderate interaction that could exacerbate diseases when taken with Ofatumumab
Samarium (153Sm) lexidronam may lead to a major life threatening interaction when taken with ... |
DB00374 | DB00562 | 1,061 | 1,014 | [
"DDInter1852",
"DDInter188"
] | Treprostinil | Benzthiazide | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used... | Moderate | 1 | [
[
[
1061,
24,
1014
]
],
[
[
1061,
24,
811
],
[
811,
40,
1014
]
],
[
[
1061,
24,
674
],
[
674,
1,
1014
]
],
[
[
1061,
24,
126
],
[
126,
... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzthiazide"
]
],
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metolazone"
],
... | Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Metolazone and Metolazone (Compound) resembles Benzthiazide (Compound)
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Trichlormethiazide and Trichlormethiazide (Compound) resembles ... |
DB08903 | DB09098 | 996 | 98 | [
"DDInter170",
"DDInter1700"
] | Bedaquiline | Somatrem | Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affe... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
996,
24,
98
]
],
[
[
996,
63,
168
],
[
168,
23,
98
]
],
[
[
996,
24,
159
],
[
159,
63,
98
]
],
[
[
996,
75,
11
],
[
11,
24,
... | [
[
[
"Bedaquiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Bedaquiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Bedaquiline may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Somatrem
Bedaquiline may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larot... |
DB00357 | DB06626 | 1,051 | 263 | [
"DDInter71",
"DDInter147"
] | Aminoglutethimide | Axitinib | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | Moderate | 1 | [
[
[
1051,
24,
263
]
],
[
[
1051,
24,
392
],
[
392,
24,
263
]
],
[
[
1051,
24,
1593
],
[
1593,
63,
263
]
],
[
[
1051,
62,
1101
],
[
1101,
... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Axitinib"
]
],
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
... | Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Axitinib
Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib ... |
DB06663 | DB11113 | 1,154 | 657 | [
"DDInter1398",
"DDInter307"
] | Pasireotide | Castor oil | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of , which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic... | Moderate | 1 | [
[
[
1154,
24,
657
]
],
[
[
1154,
64,
1079
],
[
1079,
24,
657
]
],
[
[
1154,
25,
927
],
[
927,
63,
657
]
],
[
[
1154,
25,
985
],
[
985,
... | [
[
[
"Pasireotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Castor oil"
]
],
[
[
"Pasireotide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Telavancin"
],
[
"Telavanc... | Pasireotide may lead to a major life threatening interaction when taken with Telavancin and Telavancin may cause a moderate interaction that could exacerbate diseases when taken with Castor oil
Pasireotide may lead to a major life threatening interaction when taken with Encorafenib and Encorafenib may cause a moderate ... |
DB01611 | DB06674 | 1,487 | 908 | [
"DDInter893",
"DDInter837"
] | Hydroxychloroquine | Golimumab | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Moderate | 1 | [
[
[
1487,
24,
908
]
],
[
[
1487,
63,
268
],
[
268,
24,
908
]
],
[
[
1487,
24,
505
],
[
505,
63,
908
]
],
[
[
1487,
25,
1328
],
[
1328,
... | [
[
[
"Hydroxychloroquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Golimumab"
]
],
[
[
"Hydroxychloroquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterfero... | Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2b and Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Golimumab
Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases ... |
DB01259 | DB06403 | 392 | 1,204 | [
"DDInter1024",
"DDInter62"
] | Lapatinib | Ambrisentan | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Ambrisentan is an orally active selective type A endothelin receptor antagonist indicated for the treatment of pulmonary arterial hypertension. It is approved in Europe, Canada and the United States for use as a single agent to improve exercise ability and delay clinical worsening. In addition, it is approved in the Un... | Moderate | 1 | [
[
[
392,
24,
1204
]
],
[
[
392,
63,
600
],
[
600,
23,
1204
]
],
[
[
392,
25,
760
],
[
760,
62,
1204
]
],
[
[
392,
64,
609
],
[
609,
... | [
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ambrisentan"
]
],
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
],
[
... | Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a minor interaction that can limit clinical effects when taken with Ambrisentan
Lapatinib may lead to a major life threatening interaction when taken with Cobicistat and Cobicistat may cause a... |
DB01224 | DB12130 | 623 | 1,017 | [
"DDInter1553",
"DDInter1094"
] | Quetiapine | Lorlatinib | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
623,
24,
1017
]
],
[
[
623,
64,
1101
],
[
1101,
23,
1017
]
],
[
[
623,
63,
590
],
[
590,
24,
1017
]
],
[
[
623,
24,
1491
],
[
1491,
... | [
[
[
"Quetiapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Quetiapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
[
"Bexarotene... | Quetiapine may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Quetiapine may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and Acetohexamide may ca... |
DB01110 | DB06595 | 86 | 1,491 | [
"DDInter1209",
"DDInter1214"
] | Miconazole | Midostaurin | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
86,
24,
1491
]
],
[
[
86,
24,
761
],
[
761,
24,
1491
]
],
[
[
86,
63,
289
],
[
289,
24,
1491
]
],
[
[
86,
24,
1017
],
[
1017,
63... | [
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
],
[
... | Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin and Saxagliptin may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin
Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Cerivastatin and C... |
DB00295 | DB00844 | 475 | 314 | [
"DDInter1244",
"DDInter1257"
] | Morphine | Nalbuphine | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | A narcotic used as a pain medication. It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. Nalbuphine is the only opioid analgesic that is not a controlled substance in the United States. | Major | 2 | [
[
[
475,
25,
314
]
],
[
[
475,
25,
828
],
[
828,
40,
314
]
],
[
[
475,
24,
173
],
[
173,
63,
314
]
],
[
[
475,
25,
421
],
[
421,
1,
... | [
[
[
"Morphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nalbuphine"
]
],
[
[
"Morphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Oxycodone"
],
[
"Oxycodone",
"{u} (Compou... | Morphine may lead to a major life threatening interaction when taken with Oxycodone and Oxycodone (Compound) resembles Nalbuphine (Compound)
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Naloxone and Naloxone may cause a moderate interaction that could exacerbate diseases when... |
DB00008 | DB01073 | 491 | 1,488 | [
"DDInter1407",
"DDInter745"
] | Peginterferon alfa-2a | Fludarabine | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Moderate | 1 | [
[
[
491,
24,
1488
]
],
[
[
491,
24,
372
],
[
372,
1,
1488
]
],
[
[
491,
24,
1253
],
[
1253,
24,
1488
]
],
[
[
491,
24,
36
],
[
36,
6... | [
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
]
],
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clof... | Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine (Compound) resembles Fludarabine (Compound)
Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Palifermin and Palifermin may cause a modera... |
DB00030 | DB09038 | 1,685 | 1,450 | [
"DDInter934",
"DDInter636"
] | Insulin human | Empagliflozin | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
1685,
24,
1450
]
],
[
[
1685,
23,
1103
],
[
1103,
23,
1450
]
],
[
[
1685,
24,
461
],
[
461,
24,
1450
]
],
[
[
1685,
24,
192
],
[
192,
... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Insulin human",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
],
... | Insulin human may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Empagliflozin
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Timolol and Timo... |
DB01222 | DB11986 | 617 | 484 | [
"DDInter246",
"DDInter648"
] | Budesonide | Entrectinib | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
617,
24,
484
]
],
[
[
617,
63,
998
],
[
998,
24,
484
]
],
[
[
617,
62,
1674
],
[
1674,
24,
484
]
],
[
[
617,
24,
1478
],
[
1478,
... | [
[
[
"Budesonide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Budesonide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylbutazone"
],
... | Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutazone and Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib
Budesonide may cause a minor interaction that can limit clinical effects when taken with Orciprenaline ... |
DB00781 | DB01099 | 1,481 | 1,272 | [
"DDInter1489",
"DDInter744"
] | Polymyxin B | Flucytosine | Polymyxin B was discovered in the 1940s. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic[A176426,FDA Label]. All gram-positive bacteria, fungi, and the gram... | A fluorinated cytosine analog that is used as an antifungal agent. | Moderate | 1 | [
[
[
1481,
24,
1272
]
],
[
[
1481,
21,
29196
],
[
29196,
60,
1272
]
],
[
[
1481,
25,
1448
],
[
1448,
24,
1272
]
],
[
[
1481,
1,
1441
],
[
1... | [
[
[
"Polymyxin B",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flucytosine"
]
],
[
[
"Polymyxin B",
"{u} (Compound) causes {v} (Side Effect)",
"Paraesthesia"
],
[
"Paraesthesia",
"{u} (Side Effect... | Polymyxin B (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Flucytosine (Compound)
Polymyxin B may lead to a major life threatening interaction when taken with Streptomycin and Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with Flucytosi... |
DB00675 | DB11963 | 888 | 1,045 | [
"DDInter1744",
"DDInter465"
] | Tamoxifen | Dacomitinib | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Dacomitinib, designed as (2E)-N-16-4-(piperidin-1-yl) but-2-enamide, is an oral highly selective quinazalone part of the second-generation tyrosine kinase inhibitors which are characterized by the irreversible binding at the ATP domain of the epidermal growth factor receptor family kinase domains. Dacomitinib was devel... | Major | 2 | [
[
[
888,
25,
1045
]
],
[
[
888,
24,
479
],
[
479,
23,
1045
]
],
[
[
888,
25,
1039
],
[
1039,
24,
1045
]
],
[
[
888,
24,
1664
],
[
1664,
... | [
[
[
"Tamoxifen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dacomitinib"
]
],
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
],
[
"Donepezil",
... | Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepezil may cause a minor interaction that can limit clinical effects when taken with Dacomitinib
Tamoxifen may lead to a major life threatening interaction when taken with Dexfenfluramine and Dexfenfluramine may c... |
DB00242 | DB01206 | 1,064 | 37 | [
"DDInter392",
"DDInter1086"
] | Cladribine | Lomustine | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | An alkylating agent of value against both hematologic malignancies and solid tumors. | Major | 2 | [
[
[
1064,
25,
37
]
],
[
[
1064,
5,
11555
],
[
11555,
44,
37
]
],
[
[
1064,
21,
28722
],
[
28722,
60,
37
]
],
[
[
1064,
25,
147
],
[
147,
... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomustine"
]
],
[
[
"Cladribine",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease) is treated by... | Cladribine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Lomustine (Compound)
Cladribine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Lomustine (Compound)
Cladribine may lead to a major life threatening interaction when taken with Vinblasti... |
DB00327 | DB00792 | 421 | 832 | [
"DDInter890",
"DDInter1878"
] | Hydromorphone | Tripelennamine | Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of [morphine] that has been available clinically since 1920. Structurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 a... | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Moderate | 1 | [
[
[
421,
24,
832
]
],
[
[
421,
24,
100
],
[
100,
63,
832
]
],
[
[
421,
24,
649
],
[
649,
1,
832
]
],
[
[
421,
24,
1594
],
[
1594,
24... | [
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
]
],
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
... | Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine
Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with C... |
DB00708 | DB09054 | 1,454 | 384 | [
"DDInter1718",
"DDInter905"
] | Sufentanil | Idelalisib | Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to w... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
1454,
24,
384
]
],
[
[
1454,
25,
222
],
[
222,
23,
384
]
],
[
[
1454,
63,
58
],
[
58,
24,
384
]
],
[
[
1454,
24,
259
],
[
259,
2... | [
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Sufentanil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
],
[
"Sibutrami... | Sufentanil may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may cause a ... |
DB00304 | DB06372 | 1,657 | 259 | [
"DDInter508",
"DDInter1594"
] | Desogestrel | Rilonacept | Desogestrel, a prodrug, is a third generation progestogen and hence, a member of the gonane family which was largely used in Europe before being approved in the US and Canada. It was firstly generated from a study that showed that 11-beta and 11-alkylidene substituent in nortestosterone can enhance the biological activ... | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
1657,
24,
259
]
],
[
[
1657,
1,
1336
],
[
1336,
24,
259
]
],
[
[
1657,
24,
812
],
[
812,
63,
259
]
],
[
[
1657,
40,
890
],
[
890,
... | [
[
[
"Desogestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Desogestrel",
"{u} (Compound) resembles {v} (Compound)",
"Etonogestrel"
],
[
"Etonogestrel",
"{u} may cause a m... | Desogestrel (Compound) resembles Etonogestrel (Compound) and Etonogestrel may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept
Desogestrel may cause a moderate interaction that could exacerbate diseases when taken with Siltuximab and Siltuximab may cause a moderate interaction that... |
DB00349 | DB01114 | 902 | 272 | [
"DDInter401",
"DDInter362"
] | Clobazam | Chlorpheniramine | Clobazam belongs to the 1,5-benzodiazepine class of drugs and is marketed under different names, Onfi, Frisium, Urbanyl, and others.. Clobazam was first synthesized in 1966 and first published in 1969, following the incidental synthesis and discovery of the first benzodiazepine chlordiazepoxide in the 1950s. Unlike old... | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Moderate | 1 | [
[
[
902,
24,
272
]
],
[
[
902,
40,
1237
],
[
1237,
63,
272
]
],
[
[
902,
24,
849
],
[
849,
63,
272
]
],
[
[
902,
24,
128
],
[
128,
2... | [
[
[
"Clobazam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
]
],
[
[
"Clobazam",
"{u} (Compound) resembles {v} (Compound)",
"Clomipramine"
],
[
"Clomipramine",
"{u} may cause a m... | Clobazam (Compound) resembles Clomipramine (Compound) and Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Clobazam may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that... |
DB00738 | DB09043 | 485 | 135 | [
"DDInter1420",
"DDInter36"
] | Pentamidine | Albiglutide | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Albiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on A... | Moderate | 1 | [
[
[
485,
24,
135
]
],
[
[
485,
63,
1647
],
[
1647,
23,
135
]
],
[
[
485,
24,
519
],
[
519,
24,
135
]
],
[
[
485,
63,
176
],
[
176,
2... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Albiglutide"
]
],
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acarbose"
],
[
... | Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose may cause a minor interaction that can limit clinical effects when taken with Albiglutide
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone and Paliper... |
DB00357 | DB00370 | 1,051 | 1,251 | [
"DDInter71",
"DDInter1230"
] | Aminoglutethimide | Mirtazapine | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | Moderate | 1 | [
[
[
1051,
24,
1251
]
],
[
[
1051,
6,
7950
],
[
7950,
45,
1251
]
],
[
[
1051,
21,
28680
],
[
28680,
60,
1251
]
],
[
[
1051,
24,
392
],
[
39... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mirtazapine"
]
],
[
[
"Aminoglutethimide",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {... | Aminoglutethimide (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Mirtazapine (Compound)
Aminoglutethimide (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Mirtazapine (Compound)
Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Lapati... |
DB00252 | DB01268 | 362 | 1,151 | [
"DDInter1460",
"DDInter1731"
] | Phenytoin | Sunitinib | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Major | 2 | [
[
[
362,
25,
1151
]
],
[
[
362,
24,
1311
],
[
1311,
1,
1151
]
],
[
[
362,
6,
4973
],
[
4973,
45,
1151
]
],
[
[
362,
21,
29170
],
[
29170,
... | [
[
[
"Phenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sunitinib"
]
],
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
],
[
"Metoclopr... | Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide (Compound) resembles Sunitinib (Compound)
Phenytoin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sunitinib (Compound)
Phenytoin (Compound) causes Cardiac failure congestive (Side Eff... |
DB00633 | DB01142 | 614 | 1,264 | [
"DDInter520",
"DDInter593"
] | Dexmedetomidine | Doxepin | An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine. | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
614,
24,
1264
]
],
[
[
614,
24,
401
],
[
401,
24,
1264
]
],
[
[
614,
63,
1594
],
[
1594,
24,
1264
]
],
[
[
614,
24,
649
],
[
649,
... | [
[
[
"Dexmedetomidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Dexmedetomidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],... | Dexmedetomidine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Dexmedetomidine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine... |
DB01218 | DB12332 | 1,493 | 1,619 | [
"DDInter852",
"DDInter1626"
] | Halofantrine | Rucaparib | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Major | 2 | [
[
[
1493,
25,
1619
]
],
[
[
1493,
62,
307
],
[
307,
23,
1619
]
],
[
[
1493,
64,
87
],
[
87,
24,
1619
]
],
[
[
1493,
25,
1662
],
[
1662,
... | [
[
[
"Halofantrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rucaparib"
]
],
[
[
"Halofantrine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
],
[
"Modafinil"... | Halofantrine may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Halofantrine may lead to a major life threatening interaction when taken with Amoxapine and Amoxapine may cause a mod... |
DB01611 | DB12834 | 1,487 | 148 | [
"DDInter893",
"DDInter1649"
] | Hydroxychloroquine | Secnidazole | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent. It is structurally related to other 5-nitroimidazoles, including and , but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class. Secnidazole is selective against many anaerobic Gram-positive ... | Moderate | 1 | [
[
[
1487,
24,
148
]
],
[
[
1487,
25,
1593
],
[
1593,
24,
148
]
],
[
[
1487,
24,
1480
],
[
1480,
24,
148
]
],
[
[
1487,
63,
1191
],
[
1191,... | [
[
[
"Hydroxychloroquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secnidazole"
]
],
[
[
"Hydroxychloroquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
],
[
... | Hydroxychloroquine may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Secnidazole
Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib and Ixazom... |
DB00358 | DB08875 | 1,010 | 1,618 | [
"DDInter1140",
"DDInter262"
] | Mefloquine | Cabozantinib | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
1010,
25,
1618
]
],
[
[
1010,
23,
112
],
[
112,
23,
1618
]
],
[
[
1010,
24,
384
],
[
384,
63,
1618
]
],
[
[
1010,
24,
1249
],
[
1249,
... | [
[
[
"Mefloquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Mefloquine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Mefloquine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Id... |
DB00444 | DB00559 | 63 | 152 | [
"DDInter1765",
"DDInter223"
] | Teniposide | Bosentan | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure. | Moderate | 1 | [
[
[
63,
24,
152
]
],
[
[
63,
6,
6017
],
[
6017,
45,
152
]
],
[
[
63,
7,
5795
],
[
5795,
57,
152
]
],
[
[
63,
21,
29076
],
[
29076,
6... | [
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosentan"
]
],
[
[
"Teniposide",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
... | Teniposide (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Bosentan (Compound)
Teniposide (Compound) upregulates PSMB8 (Gene) and PSMB8 (Gene) is downregulated by Bosentan (Compound)
Teniposide (Compound) causes Liver function test abnormal (Side Effect) and Liver function test abnormal (Side Effect) is ca... |
DB06616 | DB14575 | 594 | 733 | [
"DDInter224",
"DDInter674"
] | Bosutinib | Eslicarbazepine | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Eslicarbazepine is an anti-epileptic medication available commercially as [eslicarbazepine acetate]. | Moderate | 1 | [
[
[
594,
24,
733
]
],
[
[
594,
63,
1101
],
[
1101,
23,
733
]
],
[
[
594,
63,
1491
],
[
1491,
24,
733
]
],
[
[
594,
25,
351
],
[
351,
... | [
[
[
"Bosutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eslicarbazepine"
]
],
[
[
"Bosutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[... | Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Eslicarbazepine
Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin and Mido... |
DB00836 | DB09078 | 543 | 1,228 | [
"DDInter1088",
"DDInter1036"
] | Loperamide | Lenvatinib | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Moderate | 1 | [
[
[
543,
24,
1228
]
],
[
[
543,
24,
112
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[
112,
23,
1228
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[
[
543,
63,
1100
],
[
1100,
24,
1228
]
],
[
[
543,
24,
938
],
[
938,
... | [
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lenvatinib"
]
],
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[... | Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lenvatinib
Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and V... |
DB00450 | DB01246 | 78 | 820 | [
"DDInter603",
"DDInter45"
] | Droperidol | Alimemazine | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | A phenothiazine derivative that is used as an antipruritic. | Major | 2 | [
[
[
78,
25,
820
]
],
[
[
78,
24,
104
],
[
104,
40,
820
]
],
[
[
78,
25,
401
],
[
401,
24,
820
]
],
[
[
78,
24,
649
],
[
649,
1,
... | [
[
[
"Droperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alimemazine"
]
],
[
[
"Droperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
[
"Methdil... | Droperidol may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (Compound)
Droperidol may lead to a major life threatening interaction when taken with Promethazine and Promethazine may cause a moderate interaction that could exace... |
DB01124 | DB01577 | 1,411 | 1,529 | [
"DDInter1828",
"DDInter1161"
] | Tolbutamide | Metamfetamine | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Metamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug, and a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. It is a scheduled drug in most countries due to its high potentia... | Moderate | 1 | [
[
[
1411,
24,
1529
]
],
[
[
1411,
63,
939
],
[
939,
40,
1529
]
],
[
[
1411,
24,
22
],
[
22,
24,
1529
]
],
[
[
1411,
24,
1039
],
[
1039,
... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metamfetamine"
]
],
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzphetamine"
],
... | Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Benzphetamine and Benzphetamine (Compound) resembles Metamfetamine (Compound)
Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine and Ephedrine may cause a moderate interaction t... |
DB00370 | DB01612 | 1,251 | 1,637 | [
"DDInter1230",
"DDInter92"
] | Mirtazapine | Amyl Nitrite | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Moderate | 1 | [
[
[
1251,
24,
1637
]
],
[
[
1251,
63,
475
],
[
475,
24,
1637
]
],
[
[
1251,
24,
401
],
[
401,
24,
1637
]
],
[
[
1251,
25,
593
],
[
593,
... | [
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Morphine"
],
[
... | Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Prom... |
DB01263 | DB09078 | 859 | 1,228 | [
"DDInter1494",
"DDInter1036"
] | Posaconazole | Lenvatinib | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Moderate | 1 | [
[
[
859,
24,
1228
]
],
[
[
859,
62,
112
],
[
112,
23,
1228
]
],
[
[
859,
63,
609
],
[
609,
24,
1228
]
],
[
[
859,
24,
1151
],
[
1151,
... | [
[
[
"Posaconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lenvatinib"
]
],
[
[
"Posaconazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Posaconazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lenvatinib
Posaconazole may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin ... |
DB00694 | DB00938 | 51 | 455 | [
"DDInter485",
"DDInter1635"
] | Daunorubicin | Salmeterol | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Moderate | 1 | [
[
[
51,
24,
455
]
],
[
[
51,
24,
688
],
[
688,
63,
455
]
],
[
[
51,
6,
8374
],
[
8374,
45,
455
]
],
[
[
51,
7,
8606
],
[
8606,
46,
... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
]
],
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
],
... | Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol
Daunorubicin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Salmeterol (Compound)
Daunorubicin (... |
DB06810 | DB08918 | 397 | 41 | [
"DDInter1484",
"DDInter1059"
] | Plicamycin | Levomilnacipran | Plicamycin is an antineoplastic antibiotic produced by Streptomyces plicatus. It has been used in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of hypercalcemia. The manufacturer discontinued plicamycin in 2000. | Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake.[A261181, A38560] Levomilnacipran is the more active 1S,2R-enantiomer in the racemate [milnacipran].[A261181, L47956] Once administered, interc... | Moderate | 1 | [
[
[
397,
24,
41
]
],
[
[
397,
63,
901
],
[
901,
40,
41
]
],
[
[
397,
25,
498
],
[
498,
63,
41
]
],
[
[
397,
64,
330
],
[
330,
24,
... | [
[
[
"Plicamycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
]
],
[
[
"Plicamycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milnacipran"
],
... | Plicamycin may cause a moderate interaction that could exacerbate diseases when taken with Milnacipran and Milnacipran (Compound) resembles Levomilnacipran (Compound)
Plicamycin may lead to a major life threatening interaction when taken with Edoxaban and Edoxaban may cause a moderate interaction that could exacerbate ... |
DB00112 | DB08913 | 374 | 1,186 | [
"DDInter201",
"DDInter1561"
] | Bevacizumab | Radium Ra 223 dichloride | There is a great deal of evidence indicating that vascular endothelial growth factor (VEGF) is important for the survival and proliferation of cancer cells.[A192939,A192837,A192891,A193275] VEGF plays an important role in angiogenesis, lymphangiogenesis, and tumor growth, which are all factors that contribute to its at... | Radium Ra 223 Dichloride is a radiopharmaceutical containing the radioisotope radium-223 that emits short range but high linear energy alpha particles. As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas of high bone turnover as seen in bone metastases. It was first ap... | Moderate | 1 | [
[
[
374,
24,
1186
]
],
[
[
374,
24,
869
],
[
869,
24,
1186
]
],
[
[
374,
24,
810
],
[
810,
63,
1186
]
],
[
[
374,
25,
770
],
[
770,
... | [
[
[
"Bevacizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Radium Ra 223 dichloride"
]
],
[
[
"Bevacizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Topotecan"
... | Bevacizumab may cause a moderate interaction that could exacerbate diseases when taken with Topotecan and Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Radium Ra 223 dichloride
Bevacizumab may cause a moderate interaction that could exacerbate diseases when taken with Stronti... |
DB00563 | DB00963 | 663 | 1,263 | [
"DDInter1174",
"DDInter241"
] | Methotrexate | Bromfenac | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool f... | Major | 2 | [
[
[
663,
25,
1263
]
],
[
[
663,
25,
935
],
[
935,
40,
1263
]
],
[
[
663,
64,
831
],
[
831,
40,
1263
]
],
[
[
663,
25,
1512
],
[
1512,
... | [
[
[
"Methotrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bromfenac"
]
],
[
[
"Methotrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ketoprofen"
],
[
"Ketoprofen",
"{u... | Methotrexate may lead to a major life threatening interaction when taken with Ketoprofen and Ketoprofen (Compound) resembles Bromfenac (Compound)
Methotrexate may lead to a major life threatening interaction when taken with Indomethacin and Indomethacin (Compound) resembles Bromfenac (Compound)
Methotrexate may lead to... |
DB00836 | DB11986 | 543 | 484 | [
"DDInter1088",
"DDInter648"
] | Loperamide | Entrectinib | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
543,
24,
484
]
],
[
[
543,
24,
112
],
[
112,
23,
484
]
],
[
[
543,
24,
1539
],
[
1539,
24,
484
]
],
[
[
543,
63,
322
],
[
322,
2... | [
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Ofloxacin and Of... |
DB00675 | DB01244 | 888 | 762 | [
"DDInter1744",
"DDInter192"
] | Tamoxifen | Bepridil | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Major | 2 | [
[
[
888,
25,
762
]
],
[
[
888,
25,
1376
],
[
1376,
24,
762
]
],
[
[
888,
1,
1661
],
[
1661,
40,
762
]
],
[
[
888,
64,
675
],
[
675,
... | [
[
[
"Tamoxifen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bepridil"
]
],
[
[
"Tamoxifen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Diphenhydramine"
],
[
"Diphenhydramine",
... | Tamoxifen may lead to a major life threatening interaction when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Bepridil
Tamoxifen (Compound) resembles Phenoxybenzamine (Compound) and Phenoxybenzamine (Compound) resembles Bepridil (Compound)... |
DB00023 | DB00382 | 305 | 62 | [
"DDInter127",
"DDInter1734"
] | Asparaginase Escherichia coli | Tacrine | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market. | Moderate | 1 | [
[
[
305,
24,
62
]
],
[
[
305,
24,
848
],
[
848,
62,
62
]
],
[
[
305,
24,
79
],
[
79,
63,
62
]
],
[
[
305,
24,
482
],
[
482,
24,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tacrine"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen may cause a minor interaction that can limit clinical effects when taken with Tacrine
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when t... |
DB00370 | DB00405 | 1,251 | 128 | [
"DDInter1230",
"DDInter517"
] | Mirtazapine | Dexbrompheniramine | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Moderate | 1 | [
[
[
1251,
24,
128
]
],
[
[
1251,
24,
662
],
[
662,
63,
128
]
],
[
[
1251,
24,
28
],
[
28,
1,
128
]
],
[
[
1251,
6,
10104
],
[
10104,
... | [
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexbrompheniramine"
]
],
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
... | Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine
Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Bisac... |
DB01181 | DB14444 | 1,532 | 151 | [
"DDInter906",
"DDInter924"
] | Ifosfamide | Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immuno... | Moderate | 1 | [
[
[
1532,
24,
151
]
],
[
[
1532,
63,
66
],
[
66,
24,
151
]
],
[
[
1532,
25,
375
],
[
375,
24,
151
]
],
[
[
1532,
24,
1531
],
[
1531,
... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)"
]
],
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could e... | Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Ifosfamide may lead to a major life t... |
DB00312 | DB00530 | 1,023 | 1,195 | [
"DDInter1423",
"DDInter667"
] | Pentobarbital | Erlotinib | A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Dr... | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | Moderate | 1 | [
[
[
1023,
24,
1195
]
],
[
[
1023,
24,
883
],
[
883,
40,
1195
]
],
[
[
1023,
6,
8374
],
[
8374,
45,
1195
]
],
[
[
1023,
21,
28762
],
[
2876... | [
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Erlotinib"
]
],
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
... | Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Erlotinib (Compound)
Pentobarbital (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Erlotinib (Compound)
Pentobarbital (Compound) causes Headache (Side Effect) and Heada... |
DB01218 | DB11796 | 1,493 | 1,612 | [
"DDInter852",
"DDInter786"
] | Halofantrine | Fostemsavir | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor. It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir prevents the first step in the... | Major | 2 | [
[
[
1493,
25,
1612
]
],
[
[
1493,
24,
1476
],
[
1476,
62,
1612
]
],
[
[
1493,
63,
1101
],
[
1101,
23,
1612
]
],
[
[
1493,
24,
1040
],
[
10... | [
[
[
"Halofantrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fostemsavir"
]
],
[
[
"Halofantrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
],
[
"Briga... | Halofantrine may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a minor interaction that can limit clinical effects when taken with Fostemsavir
Halofantrine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bex... |
DB01403 | DB12141 | 9 | 971 | [
"DDInter1175",
"DDInter817"
] | Methotrimeprazine | Gilteritinib | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
9,
24,
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]
],
[
[
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[
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[
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[
823,
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[
[
"Methotrimeprazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Methotrimeprazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole... | Methotrimeprazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Methotrimeprazine may cause a moderate interaction that could exacerbate diseases when taken with Pen... |
DB01155 | DB08882 | 872 | 1,281 | [
"DDInter813",
"DDInter1070"
] | Gemifloxacin | Linagliptin | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
872,
24,
1281
]
],
[
[
872,
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],
[
1002,
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1281
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[
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872,
21,
29547
],
[
29547,
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],
[
[
872,
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],
[
251,
... | [
[
[
"Gemifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Gemifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
],
... | Gemifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Gemifloxacin (Compound) causes Skin exfoliation (Side Effect) and Skin exfoliation (Side Effect) is caused by Linagliptin (Compound)
Gemifloxacin may lead to... |
DB04835 | DB12010 | 1,655 | 214 | [
"DDInter1125",
"DDInter785"
] | Maraviroc | Fostamatinib | Maraviroc (brand-named Selzentry, or Celsentri outside the U.S.) is a chemokine receptor antagonist drug developed by the drug company Pfizer that is designed to act against HIV by interfering with the interaction between HIV and CCR5. It was originally labelled as UK-427857 during development but was assigned the Mara... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
1655,
24,
214
]
],
[
[
1655,
63,
723
],
[
723,
24,
214
]
],
[
[
1655,
24,
1478
],
[
1478,
24,
214
]
],
[
[
1655,
24,
1017
],
[
1017,
... | [
[
[
"Maraviroc",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Maraviroc",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[
... | Maraviroc may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Maraviroc may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaft... |
DB00569 | DB01242 | 553 | 1,237 | [
"DDInter775",
"DDInter410"
] | Fondaparinux | Clomipramine | Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in he... | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Moderate | 1 | [
[
[
553,
24,
1237
]
],
[
[
553,
21,
28703
],
[
28703,
60,
1237
]
],
[
[
553,
64,
1578
],
[
1578,
24,
1237
]
],
[
[
553,
25,
397
],
[
397,
... | [
[
[
"Fondaparinux",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
]
],
[
[
"Fondaparinux",
"{u} (Compound) causes {v} (Side Effect)",
"Pruritus"
],
[
"Pruritus",
"{u} (Side Effect) is ... | Fondaparinux (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Clomipramine (Compound)
Fondaparinux may lead to a major life threatening interaction when taken with Lepirudin and Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine
Fondapa... |
DB00877 | DB01023 | 629 | 409 | [
"DDInter1678",
"DDInter716"
] | Sirolimus | Felodipine | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte... | Moderate | 1 | [
[
[
629,
24,
409
]
],
[
[
629,
63,
376
],
[
376,
40,
409
]
],
[
[
629,
63,
1428
],
[
1428,
1,
409
]
],
[
[
629,
24,
336
],
[
336,
40... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Felodipine"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amlodipine"
],
[
... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Amlodipine and Amlodipine (Compound) resembles Felodipine (Compound)
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradipine (Compound) resembles Felodipine (Compound)
Si... |
DB01168 | DB11186 | 1,053 | 1,609 | [
"DDInter1526",
"DDInter1427"
] | Procarbazine | Pentoxyverine | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Major | 2 | [
[
[
1053,
25,
1609
]
],
[
[
1053,
64,
314
],
[
314,
24,
1609
]
],
[
[
1053,
63,
508
],
[
508,
24,
1609
]
],
[
[
1053,
24,
1190
],
[
1190,
... | [
[
[
"Procarbazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Procarbazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nalbuphine"
],
[
"Nalbuphine",
... | Procarbazine may lead to a major life threatening interaction when taken with Nalbuphine and Nalbuphine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine may c... |
DB00290 | DB14444 | 329 | 151 | [
"DDInter219",
"DDInter924"
] | Bleomycin | Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) | A complex of related glycopeptide antibiotics from <i>Streptomyces verticillus</i> consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin. | A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immuno... | Moderate | 1 | [
[
[
329,
24,
151
]
],
[
[
329,
63,
66
],
[
66,
24,
151
]
],
[
[
329,
24,
134
],
[
134,
24,
151
]
],
[
[
329,
25,
850
],
[
850,
24,
... | [
[
[
"Bleomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)"
]
],
[
[
"Bleomycin",
"{u} may cause a moderate interaction that could exa... | Bleomycin may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Bleomycin may cause a moderate interac... |
DB00912 | DB00939 | 473 | 1,338 | [
"DDInter1581",
"DDInter1135"
] | Repaglinide | Meclofenamic acid | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. | Moderate | 1 | [
[
[
473,
24,
1338
]
],
[
[
473,
24,
1479
],
[
1479,
63,
1338
]
],
[
[
473,
21,
28900
],
[
28900,
60,
1338
]
],
[
[
473,
63,
752
],
[
752,
... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meclofenamic acid"
]
],
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic ac... | Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Meclofenamic acid
Repaglinide (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side ... |
DB00225 | DB00612 | 457 | 1,121 | [
"DDInter794",
"DDInter216"
] | Gadodiamide | Bisoprolol | Gadodiamide is a linear, non-ionic gadolinium-based contrast agent (GBCA) that is used in magnetic resonance imaging (MRI) procedures to assist in the visualization of blood vessels.[A263086,A263091] GBCAs constitute the largest group of MR agents, and they are thought to be safer than nonionic iodinated contrast agent... | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | Moderate | 1 | [
[
[
457,
24,
1121
]
],
[
[
457,
24,
819
],
[
819,
40,
1121
]
],
[
[
457,
63,
726
],
[
726,
1,
1121
]
],
[
[
457,
21,
28997
],
[
28997,
... | [
[
[
"Gadodiamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisoprolol"
]
],
[
[
"Gadodiamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acebutolol"
],
[
... | Gadodiamide may cause a moderate interaction that could exacerbate diseases when taken with Acebutolol and Acebutolol (Compound) resembles Bisoprolol (Compound)
Gadodiamide may cause a moderate interaction that could exacerbate diseases when taken with Betaxolol and Betaxolol (Compound) resembles Bisoprolol (Compound)
... |
DB00524 | DB11057 | 811 | 720 | [
"DDInter1199",
"DDInter1223"
] | Metolazone | Mineral oil | A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss. | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
811,
24,
720
]
],
[
[
811,
24,
175
],
[
175,
24,
720
]
],
[
[
811,
63,
160
],
[
160,
24,
720
]
],
[
[
811,
25,
1425
],
[
1425,
2... | [
[
[
"Metolazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Metolazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],
... | Metolazone may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Metolazone may cause a moderate interaction that could exacerbate diseases when taken with Calcifediol an... |
DB04861 | DB08895 | 1,592 | 976 | [
"DDInter1271",
"DDInter1825"
] | Nebivolol | Tofacitinib | Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than [atenolol], [propranolol], or [pindolol]. Nebivolol and... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Moderate | 1 | [
[
[
1592,
24,
976
]
],
[
[
1592,
24,
407
],
[
407,
63,
976
]
],
[
[
1592,
63,
475
],
[
475,
24,
976
]
],
[
[
1592,
24,
868
],
[
868,
... | [
[
[
"Nebivolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib"
]
],
[
[
"Nebivolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
],
[
"O... | Nebivolol may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib
Nebivolol may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may cause ... |
DB00550 | DB08903 | 99 | 996 | [
"DDInter1541",
"DDInter170"
] | Propylthiouracil | Bedaquiline | A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534) | Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affe... | Moderate | 1 | [
[
[
99,
24,
996
]
],
[
[
99,
21,
29106
],
[
29106,
60,
996
]
],
[
[
99,
24,
1613
],
[
1613,
63,
996
]
],
[
[
99,
24,
372
],
[
372,
2... | [
[
[
"Propylthiouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bedaquiline"
]
],
[
[
"Propylthiouracil",
"{u} (Compound) causes {v} (Side Effect)",
"Myalgia"
],
[
"Myalgia",
"{u} (Side Effect... | Propylthiouracil (Compound) causes Myalgia (Side Effect) and Myalgia (Side Effect) is caused by Bedaquiline (Compound)
Propylthiouracil may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a and Peginterferon beta-1a may cause a moderate interaction that could exacerbate d... |
DB01174 | DB09570 | 697 | 1,480 | [
"DDInter1442",
"DDInter1002"
] | Phenobarbital | Ixazomib | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Major | 2 | [
[
[
697,
25,
1480
]
],
[
[
697,
24,
310
],
[
310,
24,
1480
]
],
[
[
697,
63,
1184
],
[
1184,
24,
1480
]
],
[
[
697,
40,
1023
],
[
1023,
... | [
[
[
"Phenobarbital",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ixazomib"
]
],
[
[
"Phenobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
"Cabaz... | Phenobarbital may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib
Phenobarbital may cause a moderate interaction that could exacerbate diseases when taken with Anakinra and An... |
DB00738 | DB11978 | 485 | 124 | [
"DDInter1420",
"DDInter822"
] | Pentamidine | Glasdegib | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
485,
24,
124
]
],
[
[
485,
23,
1247
],
[
1247,
23,
124
]
],
[
[
485,
24,
1079
],
[
1079,
24,
124
]
],
[
[
485,
24,
1032
],
[
1032,
... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Pentamidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Pentamidine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Telavancin a... |
DB00048 | DB00063 | 1,595 | 366 | [
"DDInter435",
"DDInter659"
] | Collagenase clostridium histolyticum | Eptifibatide | Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum. It is beneficial in the breakdown of collagen plaques for the treatment of Dupuytren's contracture and Peyronie's disease. The topical formulation is used for the debridement of necrotic tissue due to burns or chronic ... | Synthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation. Derived from venom of the Southeastern pygmy rattlesnake (Sistrurus miliarus barbouri), eptifibatide is a cyclic heptapeptide that belongs to the class of arginin-glycin-aspartat-mimetics. | Moderate | 1 | [
[
[
1595,
24,
366
]
],
[
[
1595,
24,
477
],
[
477,
63,
366
]
],
[
[
1595,
63,
942
],
[
942,
24,
366
]
],
[
[
1595,
24,
1432
],
[
1432,
... | [
[
[
"Collagenase clostridium histolyticum",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eptifibatide"
]
],
[
[
"Collagenase clostridium histolyticum",
"{u} may cause a moderate interaction that could exacerbate diseases wh... | Collagenase clostridium histolyticum may cause a moderate interaction that could exacerbate diseases when taken with Cilostazol and Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Eptifibatide
Collagenase clostridium histolyticum may cause a moderate interaction that could exa... |
DB00679 | DB01261 | 684 | 170 | [
"DDInter1796",
"DDInter1679"
] | Thioridazine | Sitagliptin | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
684,
24,
170
]
],
[
[
684,
6,
3486
],
[
3486,
45,
170
]
],
[
[
684,
18,
7885
],
[
7885,
46,
170
]
],
[
[
684,
7,
6448
],
[
6448,
... | [
[
[
"Thioridazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Thioridazine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compou... | Thioridazine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Sitagliptin (Compound)
Thioridazine (Compound) downregulates MELK (Gene) and MELK (Gene) is upregulated by Sitagliptin (Compound)
Thioridazine (Compound) upregulates CTSD (Gene) and CTSD (Gene) is downregulated by Sitagliptin (Compound)
Thioridaz... |
DB00009 | DB01225 | 1,271 | 500 | [
"DDInter56",
"DDInter645"
] | Alteplase | Enoxaparin | Alteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent. It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots. In the absence of fibrin, the alteplase-mediated conversion of plasminogen is limited, thanks to the high affinity between alteplas... | Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies. Enoxaparin markedly reduces the inc... | Major | 2 | [
[
[
1271,
25,
500
]
],
[
[
1271,
23,
1631
],
[
1631,
62,
500
]
],
[
[
1271,
24,
1004
],
[
1004,
63,
500
]
],
[
[
1271,
24,
311
],
[
311,
... | [
[
[
"Alteplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enoxaparin"
]
],
[
[
"Alteplase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Turmeric"
],
[
"Turmeric",
... | Alteplase may cause a minor interaction that can limit clinical effects when taken with Turmeric and Turmeric may cause a minor interaction that can limit clinical effects when taken with Enoxaparin
Alteplase may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate and Phenyl sa... |
DB00039 | DB00242 | 1,253 | 1,064 | [
"DDInter1380",
"DDInter392"
] | Palifermin | Cladribine | Palifermin is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli. Palifermin was granted FDA approval on 15 December 2004. | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Moderate | 1 | [
[
[
1253,
24,
1064
]
],
[
[
1253,
24,
1426
],
[
1426,
64,
1064
]
],
[
[
1253,
24,
869
],
[
869,
63,
1064
]
],
[
[
1253,
63,
342
],
[
342,
... | [
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cladribine"
]
],
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azacitidine"
],
[
... | Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Azacitidine and Azacitidine may lead to a major life threatening interaction when taken with Cladribine
Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Topotecan and Topotecan may cause ... |
DB01006 | DB09118 | 300 | 1,580 | [
"DDInter1040",
"DDInter1711"
] | Letrozole | Stiripentol | Letrozole, or CGS 20267, is an oral non-steroidal type II aromatase inhibitor first described in the literature in 1990.[A190543,A1559,L11623,L11626] It is a third generation aromatase inhibitor like [exemestane] and [anastrozole], meaning it does not significantly affect cortisol, aldosterone, and thyroxine. Letrozole... | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Moderate | 1 | [
[
[
300,
24,
1580
]
],
[
[
300,
24,
283
],
[
283,
63,
1580
]
],
[
[
300,
24,
98
],
[
98,
24,
1580
]
],
[
[
300,
63,
723
],
[
723,
24... | [
[
[
"Letrozole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stiripentol"
]
],
[
[
"Letrozole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
],
[
... | Letrozole may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol
Letrozole may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somatrem ... |
DB00159 | DB09030 | 940 | 840 | [
"DDInter903",
"DDInter1945"
] | Icosapent | Vorapaxar | Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conve... | Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expr... | Moderate | 1 | [
[
[
940,
24,
840
]
],
[
[
940,
24,
885
],
[
885,
24,
840
]
],
[
[
940,
24,
702
],
[
702,
25,
840
]
],
[
[
940,
63,
1167
],
[
1167,
2... | [
[
[
"Icosapent",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vorapaxar"
]
],
[
[
"Icosapent",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
],
[
... | Icosapent may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Vorapaxar
Icosapent may cause a moderate interaction that could exacerbate diseases when taken with Anagrelide and Anagr... |
DB01009 | DB01050 | 935 | 848 | [
"DDInter1009",
"DDInter900"
] | Ketoprofen | Ibuprofen | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Moderate | 1 | [
[
[
935,
24,
848
]
],
[
[
935,
1,
11531
],
[
11531,
1,
848
]
],
[
[
935,
40,
734
],
[
734,
1,
848
]
],
[
[
935,
6,
1829
],
[
1829,
4... | [
[
[
"Ketoprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
]
],
[
[
"Ketoprofen",
"{u} (Compound) resembles {v} (Compound)",
"Carprofen"
],
[
"Carprofen",
"{u} (Compound) resembles {... | Ketoprofen (Compound) resembles Carprofen (Compound) and Carprofen (Compound) resembles Ibuprofen (Compound)
Ketoprofen (Compound) resembles Naproxen (Compound) and Naproxen (Compound) resembles Ibuprofen (Compound)
Ketoprofen (Compound) binds ALB (Gene) and ALB (Gene) is bound by Ibuprofen (Compound)
Ketoprofen (Compo... |
DB00860 | DB01116 | 891 | 601 | [
"DDInter1513",
"DDInter1872"
] | Prednisolone | Trimethaphan | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | A nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hypotension during surgery. | Moderate | 1 | [
[
[
891,
24,
601
]
],
[
[
891,
63,
998
],
[
998,
1,
601
]
],
[
[
891,
25,
593
],
[
593,
63,
601
]
],
[
[
891,
1,
617
],
[
617,
63,
... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimethaphan"
]
],
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylbutazone"
]... | Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutazone and Phenylbutazone (Compound) resembles Trimethaphan (Compound)
Prednisolone may lead to a major life threatening interaction when taken with Bupropion and Bupropion may cause a moderate interaction that could ex... |
DB00494 | DB06282 | 1,533 | 516 | [
"DDInter646",
"DDInter1053"
] | Entacapone | Levocetirizine | Entacapone is a selective, reversible catechol-O-methyl transferase (COMT) inhibitor for the treatment of Parkinson's disease. It is a member of the class of nitrocatechols. When administered concomittantly with levodopa and a decarboxylase inhibitor (e.g., carbidopa), increased and more sustained plasma levodopa conce... | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
1533,
24,
516
]
],
[
[
1533,
63,
701
],
[
701,
24,
516
]
],
[
[
1533,
24,
407
],
[
407,
63,
516
]
],
[
[
1533,
24,
649
],
[
649,
... | [
[
[
"Entacapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Entacapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
... | Entacapone may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine
Entacapone may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium m... |
DB00014 | DB08871 | 521 | 36 | [
"DDInter839",
"DDInter666"
] | Goserelin | Eribulin | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
521,
24,
36
]
],
[
[
521,
5,
11579
],
[
11579,
44,
36
]
],
[
[
521,
23,
1247
],
[
1247,
23,
36
]
],
[
[
521,
24,
519
],
[
519,
2... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Goserelin",
"{u} (Compound) treats {v} (Disease)",
"breast cancer"
],
[
"breast cancer",
"{u} (Disease) is treated ... | Goserelin (Compound) treats breast cancer (Disease) and breast cancer (Disease) is treated by Eribulin (Compound)
Goserelin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Er... |
DB08908 | DB09061 | 713 | 1,627 | [
"DDInter564",
"DDInter284"
] | Dimethyl fumarate | Cannabidiol | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
713,
24,
1627
]
],
[
[
713,
24,
384
],
[
384,
23,
1627
]
],
[
[
713,
24,
351
],
[
351,
62,
1627
]
],
[
[
713,
63,
1419
],
[
1419,
... | [
[
[
"Dimethyl fumarate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Dimethyl fumarate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
... | Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a minor interaction that can limit clinical effects when taken with Cannabidiol
Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Ribocicl... |
DB01076 | DB12015 | 700 | 1,033 | [
"DDInter133",
"DDInter53"
] | Atorvastatin | Alpelisib | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
700,
24,
1033
]
],
[
[
700,
24,
951
],
[
951,
24,
1033
]
],
[
[
700,
63,
10
],
[
10,
24,
1033
]
],
[
[
700,
25,
1510
],
[
1510,
... | [
[
[
"Atorvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Atorvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
],
... | Atorvastatin may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib and Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Atorvastatin may cause a moderate interaction that could exacerbate diseases when taken with Dapsone and Daps... |
DB00812 | DB11988 | 998 | 270 | [
"DDInter1451",
"DDInter1321"
] | Phenylbutazone | Ocrelizumab | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
998,
24,
270
]
],
[
[
998,
24,
1019
],
[
1019,
24,
270
]
],
[
[
998,
63,
175
],
[
175,
24,
270
]
],
[
[
998,
64,
1172
],
[
1172,
... | [
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]... | Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort and Deflazacort may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab
Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Triamcinol... |
DB00912 | DB06335 | 473 | 761 | [
"DDInter1581",
"DDInter1646"
] | Repaglinide | Saxagliptin | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
473,
24,
761
]
],
[
[
473,
6,
8374
],
[
8374,
45,
761
]
],
[
[
473,
21,
29226
],
[
29226,
60,
761
]
],
[
[
473,
63,
307
],
[
307,
... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Repaglinide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Repaglinide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Saxagliptin (Compound)
Repaglinide (Compound) causes Sinusitis (Side Effect) and Sinusitis (Side Effect) is caused by Saxagliptin (Compound)
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and ... |
DB00209 | DB06077 | 352 | 879 | [
"DDInter1886",
"DDInter1102"
] | Trospium | Lumateperone | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Moderate | 1 | [
[
[
352,
24,
879
]
],
[
[
352,
24,
1645
],
[
1645,
24,
879
]
],
[
[
352,
24,
407
],
[
407,
63,
879
]
],
[
[
352,
35,
262
],
[
262,
2... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lumateperone"
]
],
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metformin"
],
[
... | Trospium may cause a moderate interaction that could exacerbate diseases when taken with Metformin and Metformin may cause a moderate interaction that could exacerbate diseases when taken with Lumateperone
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause... |
DB01364 | DB04861 | 22 | 1,592 | [
"DDInter650",
"DDInter1271"
] | Ephedrine | Nebivolol | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than [atenolol], [propranolol], or [pindolol]. Nebivolol and... | Moderate | 1 | [
[
[
22,
24,
1592
]
],
[
[
22,
6,
3576
],
[
3576,
45,
1592
]
],
[
[
22,
21,
28762
],
[
28762,
60,
1592
]
],
[
[
22,
24,
1450
],
[
1450,
... | [
[
[
"Ephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nebivolol"
]
],
[
[
"Ephedrine",
"{u} (Compound) binds {v} (Gene)",
"ADRB2"
],
[
"ADRB2",
"{u} (Gene) is bound by {v} (Compound)",
... | Ephedrine (Compound) binds ADRB2 (Gene) and ADRB2 (Gene) is bound by Nebivolol (Compound)
Ephedrine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Nebivolol (Compound)
Ephedrine may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflo... |
DB08827 | DB09049 | 990 | 1,135 | [
"DDInter1085",
"DDInter1261"
] | Lomitapide | Naloxegol | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Naloxegol, for "PEGylated naloxol" is a peripherally-selective opioid antagonist developed by AstraZeneca. It was approved by the FDA in September 2014 and is indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non‑cancer pain. The advantage of naloxegol over the opioid antag... | Minor | 0 | [
[
[
990,
23,
1135
]
],
[
[
990,
25,
971
],
[
971,
62,
1135
]
],
[
[
990,
24,
1297
],
[
1297,
62,
1135
]
],
[
[
990,
64,
478
],
[
478,
... | [
[
[
"Lomitapide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
]
],
[
[
"Lomitapide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gilteritinib"
],
[
"Gilteritini... | Lomitapide may lead to a major life threatening interaction when taken with Gilteritinib and Gilteritinib may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Lomitapide may cause a moderate interaction that could exacerbate diseases when taken with Osilodrostat and Osilodrostat may c... |
DB00629 | DB01069 | 390 | 401 | [
"DDInter844",
"DDInter1533"
] | Guanabenz | Promethazine | An alpha-2 selective adrenergic agonist used as an antihypertensive agent. [PubChem] | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
390,
24,
401
]
],
[
[
390,
24,
1264
],
[
1264,
63,
401
]
],
[
[
390,
24,
104
],
[
104,
24,
401
]
],
[
[
390,
21,
28709
],
[
28709,
... | [
[
[
"Guanabenz",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Guanabenz",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Guanabenz may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Guanabenz may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazi... |
DB01229 | DB06448 | 973 | 171 | [
"DDInter1378",
"DDInter1087"
] | Paclitaxel (protein-bound) | Lonafarnib | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Moderate | 1 | [
[
[
973,
24,
171
]
],
[
[
973,
63,
63
],
[
63,
24,
171
]
],
[
[
973,
24,
310
],
[
310,
63,
171
]
],
[
[
973,
64,
1064
],
[
1064,
24,... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lonafarnib"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Teniposide"
],
[
... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Lonafarnib
Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Teniposide and Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Lonafarnib
Paclitaxel... |
DB00652 | DB01181 | 234 | 1,532 | [
"DDInter1421",
"DDInter906"
] | Pentazocine | Ifosfamide | The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97) | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
234,
24,
1532
]
],
[
[
234,
21,
29209
],
[
29209,
60,
1532
]
],
[
[
234,
63,
1648
],
[
1648,
24,
1532
]
],
[
[
234,
24,
401
],
[
401,
... | [
[
[
"Pentazocine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Pentazocine",
"{u} (Compound) causes {v} (Side Effect)",
"Anorexia"
],
[
"Anorexia",
"{u} (Side Effect) is caus... | Pentazocine (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Ifosfamide (Compound)
Pentazocine may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Ifosf... |
DB00352 | DB05528 | 482 | 1,070 | [
"DDInter1814",
"DDInter1228"
] | Tioguanine | Mipomersen | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. M... | Major | 2 | [
[
[
482,
25,
1070
]
],
[
[
482,
24,
292
],
[
292,
64,
1070
]
],
[
[
482,
24,
1512
],
[
1512,
25,
1070
]
],
[
[
482,
63,
552
],
[
552,
... | [
[
[
"Tioguanine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mipomersen"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Regorafenib"
],
[
"Regorafen... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Regorafenib and Regorafenib may lead to a major life threatening interaction when taken with Mipomersen
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may lead... |
DB00363 | DB00719 | 695 | 1,219 | [
"DDInter419",
"DDInter149"
] | Clozapine | Azatadine | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Moderate | 1 | [
[
[
695,
24,
1219
]
],
[
[
695,
40,
11287
],
[
11287,
1,
1219
]
],
[
[
695,
35,
13
],
[
13,
24,
1219
]
],
[
[
695,
24,
830
],
[
830,
... | [
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azatadine"
]
],
[
[
"Clozapine",
"{u} (Compound) resembles {v} (Compound)",
"Pirenzepine"
],
[
"Pirenzepine",
"{u} (Compound) resembles... | Clozapine (Compound) resembles Pirenzepine (Compound) and Pirenzepine (Compound) resembles Azatadine (Compound)
Clozapine (Compound) resembles Cyproheptadine (Compound) and Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate in... |
DB00275 | DB06779 | 217 | 365 | [
"DDInter1330",
"DDInter470"
] | Olmesartan | Dalteparin | Olmesartan belongs to the angiotensin II receptor blocker (ARB) family of drugs, which also includes [telmisartan], [candesartan], [losartan], [valsartan], and [irbesartan]. ARBs selectively bind to angiotensin receptor 1 (AT1) and prevent the protein angiotensin II from binding and exerting its hypertensive effects, w... | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Moderate | 1 | [
[
[
217,
24,
365
]
],
[
[
217,
1,
911
],
[
911,
63,
365
]
],
[
[
217,
1,
240
],
[
240,
24,
365
]
],
[
[
217,
24,
1274
],
[
1274,
25,... | [
[
[
"Olmesartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dalteparin"
]
],
[
[
"Olmesartan",
"{u} (Compound) resembles {v} (Compound)",
"Azilsartan medoxomil"
],
[
"Azilsartan medoxomil",
"{u}... | Olmesartan (Compound) resembles Azilsartan medoxomil (Compound) and Azilsartan medoxomil may cause a moderate interaction that could exacerbate diseases when taken with Dalteparin
Olmesartan (Compound) resembles Losartan (Compound) and Losartan may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00682 | DB11952 | 126 | 800 | [
"DDInter1951",
"DDInter612"
] | Warfarin | Duvelisib | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Moderate | 1 | [
[
[
126,
24,
800
]
],
[
[
126,
24,
222
],
[
222,
23,
800
]
],
[
[
126,
62,
467
],
[
467,
24,
800
]
],
[
[
126,
63,
254
],
[
254,
24,... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
]
],
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Duvelisib
Warfarin may cause a minor interaction that can limit clinical effects when taken with Simvastatin and Simvastatin ... |
DB00927 | DB01159 | 1,559 | 419 | [
"DDInter712",
"DDInter854"
] | Famotidine | Halothane | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required... | Moderate | 1 | [
[
[
1559,
24,
419
]
],
[
[
1559,
23,
256
],
[
256,
62,
419
]
],
[
[
1559,
62,
112
],
[
112,
23,
419
]
],
[
[
1559,
24,
774
],
[
774,
... | [
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Halothane"
]
],
[
[
"Famotidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Prasugrel"
],
[
... | Famotidine may cause a minor interaction that can limit clinical effects when taken with Prasugrel and Prasugrel may cause a minor interaction that can limit clinical effects when taken with Halothane
Famotidine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazol... |
DB00816 | DB09078 | 1,674 | 1,228 | [
"DDInter1346",
"DDInter1036"
] | Orciprenaline | Lenvatinib | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Moderate | 1 | [
[
[
1674,
24,
1228
]
],
[
[
1674,
63,
1100
],
[
1100,
24,
1228
]
],
[
[
1674,
24,
938
],
[
938,
63,
1228
]
],
[
[
1674,
24,
609
],
[
609,
... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lenvatinib"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venlafaxine"
],
... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Lenvatinib
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Pitolisant an... |
DB00544 | DB00773 | 970 | 896 | [
"DDInter757",
"DDInter702"
] | Fluorouracil | Etoposide | A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Moderate | 1 | [
[
[
970,
24,
896
]
],
[
[
970,
5,
11642
],
[
11642,
44,
896
]
],
[
[
970,
6,
3486
],
[
3486,
45,
896
]
],
[
[
970,
7,
15855
],
[
15855,
... | [
[
[
"Fluorouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
]
],
[
[
"Fluorouracil",
"{u} (Compound) treats {v} (Disease)",
"urinary bladder cancer"
],
[
"urinary bladder cancer",
"... | Fluorouracil (Compound) treats urinary bladder cancer (Disease) and urinary bladder cancer (Disease) is treated by Etoposide (Compound)
Fluorouracil (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Etoposide (Compound)
Fluorouracil (Compound) upregulates SESN1 (Gene) and SESN1 (Gene) is upregulated by Etopo... |
DB01276 | DB08815 | 123 | 154 | [
"DDInter706",
"DDInter1104"
] | Exenatide | Lurasidone | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States. | Moderate | 1 | [
[
[
123,
24,
154
]
],
[
[
123,
24,
1033
],
[
1033,
63,
154
]
],
[
[
123,
24,
1446
],
[
1446,
24,
154
]
],
[
[
123,
63,
959
],
[
959,
... | [
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurasidone"
]
],
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
],
[
... | Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and Alpelisib may cause a moderate interaction that could exacerbate diseases when taken with Lurasidone
Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Lanreotide and Lanreotide... |
DB00661 | DB11837 | 122 | 1,297 | [
"DDInter1928",
"DDInter1351"
] | Verapamil | Osilodrostat | Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
122,
24,
1297
]
],
[
[
122,
25,
1135
],
[
1135,
23,
1297
]
],
[
[
122,
23,
466
],
[
466,
62,
1297
]
],
[
[
122,
23,
222
],
[
222,
... | [
[
[
"Verapamil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Verapamil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",... | Verapamil may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Verapamil may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause a ... |
DB04868 | DB06723 | 478 | 115 | [
"DDInter1293",
"DDInter58"
] | Nilotinib | Aluminum hydroxide | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | Moderate | 1 | [
[
[
478,
24,
115
]
],
[
[
478,
21,
28643
],
[
28643,
60,
115
]
],
[
[
478,
63,
1252
],
[
1252,
23,
115
]
],
[
[
478,
64,
1630
],
[
1630,
... | [
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aluminum hydroxide"
]
],
[
[
"Nilotinib",
"{u} (Compound) causes {v} (Side Effect)",
"Infection"
],
[
"Infection",
"{u} (Side Effect) i... | Nilotinib (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Aluminum hydroxide (Compound)
Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin may cause a minor interaction that can limit clinical effects when taken with Aluminum ... |
DB00512 | DB00688 | 91 | 955 | [
"DDInter1916",
"DDInter1251"
] | Vancomycin | Mycophenolate mofetil | Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear. As of January 29 2018, CutisPharma's Firvanq is the only FDA approved vancomycin oral liquid treatment option available for the the treatm... | Mycophenolate mofetil, also known as MMF or CellCept, is a prodrug of mycophenolic acid, and classified as a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). This drug is an immunosuppressant combined with drugs such as [Cyclosporine] and corticosteroids to prevent organ rejection after hepatic, ren... | Moderate | 1 | [
[
[
91,
24,
955
]
],
[
[
91,
24,
1096
],
[
1096,
40,
955
]
],
[
[
91,
21,
29233
],
[
29233,
60,
955
]
],
[
[
91,
24,
361
],
[
361,
6... | [
[
[
"Vancomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolate mofetil"
]
],
[
[
"Vancomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolic aci... | Vancomycin may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid and Mycophenolic acid (Compound) resembles Mycophenolate mofetil (Compound)
Vancomycin (Compound) causes Creatinine increased (Side Effect) and Creatinine increased (Side Effect) is caused by Mycophenolate mofet... |
DB01030 | DB12141 | 869 | 971 | [
"DDInter1835",
"DDInter817"
] | Topotecan | Gilteritinib | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
869,
24,
971
]
],
[
[
869,
24,
466
],
[
466,
62,
971
]
],
[
[
869,
24,
1097
],
[
1097,
24,
971
]
],
[
[
869,
24,
1339
],
[
1339,
... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Lasmiditan and Lasm... |
DB00188 | DB00224 | 168 | 215 | [
"DDInter222",
"DDInter917"
] | Bortezomib | Indinavir | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem] | Moderate | 1 | [
[
[
168,
24,
215
]
],
[
[
168,
24,
798
],
[
798,
1,
215
]
],
[
[
168,
6,
12523
],
[
12523,
45,
215
]
],
[
[
168,
18,
2114
],
[
2114,
... | [
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indinavir"
]
],
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nelfinavir"
],
[
... | Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Nelfinavir and Nelfinavir (Compound) resembles Indinavir (Compound)
Bortezomib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Indinavir (Compound)
Bortezomib (Compound) downregulates MIF (Gene) and MIF (Gene) is dow... |
DB00405 | DB11823 | 128 | 858 | [
"DDInter517",
"DDInter673"
] | Dexbrompheniramine | Esketamine | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Major depressive disorder (MDD) is a significant cause of disability worldwide and the most common illness preceding suicide.[L5596,A175462] On March 5, 2019, the nasal spray drug, _esketamine_, also known as _Spravato_ (by Janssen Pharmaceuticals), was approved by the FDA for treatment-resistant major depression. Eske... | Moderate | 1 | [
[
[
128,
24,
858
]
],
[
[
128,
24,
272
],
[
272,
24,
858
]
],
[
[
128,
63,
1242
],
[
1242,
24,
858
]
],
[
[
128,
74,
1594
],
[
1594,
... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esketamine"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorphenir... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Esketamine
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when take... |
DB00400 | DB01232 | 353 | 1,327 | [
"DDInter843",
"DDInter1640"
] | Griseofulvin | Saquinavir | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Moderate | 1 | [
[
[
353,
24,
1327
]
],
[
[
353,
63,
798
],
[
798,
40,
1327
]
],
[
[
353,
24,
915
],
[
915,
40,
1327
]
],
[
[
353,
6,
8374
],
[
8374,
... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saquinavir"
]
],
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nelfinavir"
],
... | Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Nelfinavir and Nelfinavir (Compound) resembles Saquinavir (Compound)
Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Atazanavir and Atazanavir (Compound) resembles Saquinavir (Compou... |
DB00009 | DB06822 | 1,271 | 802 | [
"DDInter56",
"DDInter1812"
] | Alteplase | Tinzaparin | Alteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent. It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots. In the absence of fibrin, the alteplase-mediated conversion of plasminogen is limited, thanks to the high affinity between alteplas... | Tinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for h... | Major | 2 | [
[
[
1271,
25,
802
]
],
[
[
1271,
23,
944
],
[
944,
62,
802
]
],
[
[
1271,
24,
222
],
[
222,
24,
802
]
],
[
[
1271,
24,
1427
],
[
1427,
... | [
[
[
"Alteplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tinzaparin"
]
],
[
[
"Alteplase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile",
... | Alteplase may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Tinzaparin
Alteplase may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine m... |
DB08865 | DB11113 | 1,593 | 657 | [
"DDInter448",
"DDInter307"
] | Crizotinib | Castor oil | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of , which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic... | Moderate | 1 | [
[
[
1593,
24,
657
]
],
[
[
1593,
64,
1079
],
[
1079,
24,
657
]
],
[
[
1593,
25,
927
],
[
927,
63,
657
]
],
[
[
1593,
25,
985
],
[
985,
... | [
[
[
"Crizotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Castor oil"
]
],
[
[
"Crizotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Telavancin"
],
[
"Telavancin... | Crizotinib may lead to a major life threatening interaction when taken with Telavancin and Telavancin may cause a moderate interaction that could exacerbate diseases when taken with Castor oil
Crizotinib may lead to a major life threatening interaction when taken with Encorafenib and Encorafenib may cause a moderate in... |
DB00264 | DB11363 | 88 | 1,276 | [
"DDInter1200",
"DDInter39"
] | Metoprolol | Alectinib | Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succi... | Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase. It is specifically used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein-like 4) fusion protein that causes prol... | Moderate | 1 | [
[
[
88,
24,
1276
]
],
[
[
88,
1,
819
],
[
819,
24,
1276
]
],
[
[
88,
25,
1011
],
[
1011,
24,
1276
]
],
[
[
88,
40,
887
],
[
887,
24,... | [
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alectinib"
]
],
[
[
"Metoprolol",
"{u} (Compound) resembles {v} (Compound)",
"Acebutolol"
],
[
"Acebutolol",
"{u} may cause a moderate... | Metoprolol (Compound) resembles Acebutolol (Compound) and Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Alectinib
Metoprolol may lead to a major life threatening interaction when taken with Fingolimod and Fingolimod may cause a moderate interaction that could exacerbate dise... |
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