drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00862 | DB08881 | 1,005 | 868 | [
"DDInter1918",
"DDInter1925"
] | Vardenafil | Vemurafenib | Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, ... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Major | 2 | [
[
[
1005,
25,
868
]
],
[
[
1005,
6,
8374
],
[
8374,
45,
868
]
],
[
[
1005,
21,
28847
],
[
28847,
60,
868
]
],
[
[
1005,
24,
112
],
[
112,
... | [
[
[
"Vardenafil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
]
],
[
[
"Vardenafil",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Vemura... | Vardenafil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vemurafenib (Compound)
Vardenafil (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Vemurafenib (Compound)
Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Metronidazo... |
DB01157 | DB06372 | 304 | 259 | [
"DDInter1875",
"DDInter1594"
] | Trimetrexate | Rilonacept | A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against pneumocystis pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect. | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
304,
24,
259
]
],
[
[
304,
24,
1367
],
[
1367,
63,
259
]
],
[
[
304,
63,
482
],
[
482,
24,
259
]
],
[
[
304,
24,
4
],
[
4,
24,
... | [
[
[
"Trimetrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Trimetrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis B Vaccine (Re... | Trimetrexate may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant) and Hepatitis B Vaccine (Recombinant) may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept
Trimetrexate may cause a moderate interaction that could exacerb... |
DB01085 | DB11363 | 562 | 1,276 | [
"DDInter1465",
"DDInter39"
] | Pilocarpine | Alectinib | A naturally occurring alkaloid derived from the _Pilocarpus_ plants, pilocarpine is a muscarinic acetylcholine agonist.[A262016, A262036] Pilocarpine is associated with parasympathomimetic effects by selectively working on muscarinic receptors. Pilocarpine is used to treat dry mouth and various ophthalmic conditions, i... | Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase. It is specifically used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein-like 4) fusion protein that causes prol... | Moderate | 1 | [
[
[
562,
24,
1276
]
],
[
[
562,
24,
1011
],
[
1011,
24,
1276
]
],
[
[
562,
24,
1476
],
[
1476,
63,
1276
]
],
[
[
562,
63,
770
],
[
770,
... | [
[
[
"Pilocarpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alectinib"
]
],
[
[
"Pilocarpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fingolimod"
],
[
... | Pilocarpine may cause a moderate interaction that could exacerbate diseases when taken with Fingolimod and Fingolimod may cause a moderate interaction that could exacerbate diseases when taken with Alectinib
Pilocarpine may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Briga... |
DB00374 | DB01191 | 1,061 | 1,039 | [
"DDInter1852",
"DDInter518"
] | Treprostinil | Dexfenfluramine | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Moderate | 1 | [
[
[
1061,
24,
1039
]
],
[
[
1061,
6,
6017
],
[
6017,
45,
1039
]
],
[
[
1061,
7,
5617
],
[
5617,
46,
1039
]
],
[
[
1061,
18,
4360
],
[
4360... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexfenfluramine"
]
],
[
[
"Treprostinil",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Co... | Treprostinil (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Dexfenfluramine (Compound)
Treprostinil (Compound) upregulates ARL4C (Gene) and ARL4C (Gene) is upregulated by Dexfenfluramine (Compound)
Treprostinil (Compound) downregulates TIMM9 (Gene) and TIMM9 (Gene) is downregulated by Dexfenfluramine (Com... |
DB00794 | DB01246 | 759 | 820 | [
"DDInter1521",
"DDInter45"
] | Primidone | Alimemazine | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
759,
24,
820
]
],
[
[
759,
24,
104
],
[
104,
40,
820
]
],
[
[
759,
24,
401
],
[
401,
24,
820
]
],
[
[
759,
24,
649
],
[
649,
1,
... | [
[
[
"Primidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Primidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
[
... | Primidone may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (Compound)
Primidone may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction tha... |
DB00445 | DB01087 | 322 | 1,520 | [
"DDInter655",
"DDInter1520"
] | Epirubicin | Primaquine | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Moderate | 1 | [
[
[
322,
24,
1520
]
],
[
[
322,
25,
1487
],
[
1487,
64,
1520
]
],
[
[
322,
18,
8800
],
[
8800,
57,
1520
]
],
[
[
322,
21,
28722
],
[
28722... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
]
],
[
[
"Epirubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
],
[
"Hy... | Epirubicin may lead to a major life threatening interaction when taken with Hydroxychloroquine and Hydroxychloroquine may lead to a major life threatening interaction when taken with Primaquine
Epirubicin (Compound) downregulates RBM34 (Gene) and RBM34 (Gene) is downregulated by Primaquine (Compound)
Epirubicin (Compou... |
DB09075 | DB12130 | 498 | 1,017 | [
"DDInter621",
"DDInter1094"
] | Edoxaban | Lorlatinib | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
498,
24,
1017
]
],
[
[
498,
64,
409
],
[
409,
24,
1017
]
],
[
[
498,
25,
1421
],
[
1421,
63,
1017
]
],
[
[
498,
63,
1427
],
[
1427,
... | [
[
[
"Edoxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Edoxaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Felodipine"
],
[
"Felodipine",
... | Edoxaban may lead to a major life threatening interaction when taken with Felodipine and Felodipine may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib
Edoxaban may lead to a major life threatening interaction when taken with Betrixaban and Betrixaban may cause a moderate interact... |
DB00095 | DB06273 | 66 | 980 | [
"DDInter623",
"DDInter1824"
] | Efalizumab | Tocilizumab | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Moderate | 1 | [
[
[
66,
24,
980
]
],
[
[
66,
23,
1114
],
[
1114,
62,
980
]
],
[
[
66,
23,
1461
],
[
1461,
23,
980
]
],
[
[
66,
24,
139
],
[
139,
24,... | [
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocilizumab"
]
],
[
[
"Efalizumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc sulfate"
],
[
... | Efalizumab may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Tocilizumab
Efalizumab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin ... |
DB01017 | DB09061 | 1,669 | 1,627 | [
"DDInter1224",
"DDInter284"
] | Minocycline | Cannabidiol | Minocycline was first described in the literacture in 1966. It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria. Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetr... | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
1669,
24,
1627
]
],
[
[
1669,
24,
384
],
[
384,
23,
1627
]
],
[
[
1669,
24,
1613
],
[
1613,
63,
1627
]
],
[
[
1669,
63,
267
],
[
267,
... | [
[
[
"Minocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Minocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
[... | Minocycline may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a minor interaction that can limit clinical effects when taken with Cannabidiol
Minocycline may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1... |
DB00060 | DB08916 | 912 | 26 | [
"DDInter947",
"DDInter32"
] | Interferon beta-1a | Afatinib | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label]. For oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal grow... | Moderate | 1 | [
[
[
912,
24,
26
]
],
[
[
912,
24,
883
],
[
883,
40,
26
]
],
[
[
912,
24,
651
],
[
651,
24,
26
]
],
[
[
912,
24,
1320
],
[
1320,
63,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Afatinib"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Afatinib (Compound)
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Fosphenytoin and Fosphenytoin may cause a moderate intera... |
DB00543 | DB01176 | 87 | 537 | [
"DDInter82",
"DDInter453"
] | Amoxapine | Cyclizine | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Moderate | 1 | [
[
[
87,
24,
537
]
],
[
[
87,
24,
1511
],
[
1511,
63,
537
]
],
[
[
87,
63,
1242
],
[
1242,
24,
537
]
],
[
[
87,
24,
104
],
[
104,
1,
... | [
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
]
],
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
[
... | Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetiriz... |
DB01030 | DB05239 | 869 | 866 | [
"DDInter1835",
"DDInter425"
] | Topotecan | Cobimetinib | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Moderate | 1 | [
[
[
869,
24,
866
]
],
[
[
869,
24,
214
],
[
214,
63,
866
]
],
[
[
869,
63,
482
],
[
482,
24,
866
]
],
[
[
869,
24,
248
],
[
248,
24,... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobimetinib"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
],
[
... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Cobimetinib
Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine and Tio... |
DB00002 | DB01041 | 1,284 | 770 | [
"DDInter344",
"DDInter1789"
] | Cetuximab | Thalidomide | Cetuximab is a recombinant chimeric human/mouse IgG1 monoclonal antibody that competitively binds to epidermal growth factor receptor (EGFR) and competitively inhibits the binding of epidermal growth factor (EGF). EGFR is a member of the ErbB family of receptor tyrosine kinases found in both normal and tumour cells; it... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Major | 2 | [
[
[
1284,
25,
770
]
],
[
[
1284,
24,
4
],
[
4,
63,
770
]
],
[
[
1284,
24,
60
],
[
60,
64,
770
]
],
[
[
1284,
24,
589
],
[
589,
25,
... | [
[
[
"Cetuximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thalidomide"
]
],
[
[
"Cetuximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
],
[
... | Cetuximab may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide
Cetuximab may cause a moderate interaction that could exacerbate diseases when tak... |
DB00582 | DB06626 | 1,622 | 263 | [
"DDInter1946",
"DDInter147"
] | Voriconazole | Axitinib | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | Major | 2 | [
[
[
1622,
25,
263
]
],
[
[
1622,
63,
1215
],
[
1215,
23,
263
]
],
[
[
1622,
24,
660
],
[
660,
23,
263
]
],
[
[
1622,
62,
752
],
[
752,
... | [
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Axitinib"
]
],
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lansoprazole"
],
[
"Lansop... | Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Lansoprazole and Lansoprazole may cause a minor interaction that can limit clinical effects when taken with Axitinib
Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Esomeprazole and ... |
DB01261 | DB06791 | 170 | 1,446 | [
"DDInter1679",
"DDInter1021"
] | Sitagliptin | Lanreotide | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Lanreotide is a drug employed in the management of acromegaly (a hormonal condition caused by excess growth hormone) in addition to symptoms caused by neuroendocrine tumors, especially carcinoid syndrome. This drug is a long-acting analog of the drug somatostatin, a growth hormone inhibitor. Lanreotide is manufactured ... | Moderate | 1 | [
[
[
170,
24,
1446
]
],
[
[
170,
24,
154
],
[
154,
63,
1446
]
],
[
[
170,
63,
1685
],
[
1685,
24,
1446
]
],
[
[
170,
24,
1254
],
[
1254,
... | [
[
[
"Sitagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lanreotide"
]
],
[
[
"Sitagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurasidone"
],
[
... | Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Lurasidone and Lurasidone may cause a moderate interaction that could exacerbate diseases when taken with Lanreotide
Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Insulin human and I... |
DB00414 | DB00863 | 590 | 1,194 | [
"DDInter16",
"DDInter1568"
] | Acetohexamide | Ranitidine | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as [cimetidine] and [famotidine]. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.[A176759,L10818]... | Moderate | 1 | [
[
[
590,
24,
1194
]
],
[
[
590,
24,
1127
],
[
1127,
1,
1194
]
],
[
[
590,
24,
59
],
[
59,
23,
1194
]
],
[
[
590,
63,
798
],
[
798,
2... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ranitidine"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nizatidine"
],
... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Nizatidine and Nizatidine (Compound) resembles Ranitidine (Compound)
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Etodolac and Etodolac may cause a minor interaction that can li... |
DB01235 | DB08880 | 1,191 | 1,510 | [
"DDInter1054",
"DDInter1771"
] | Levodopa | Teriflunomide | Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prev... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Moderate | 1 | [
[
[
1191,
24,
1510
]
],
[
[
1191,
63,
10
],
[
10,
24,
1510
]
],
[
[
1191,
24,
148
],
[
148,
63,
1510
]
],
[
[
1191,
24,
36
],
[
36,
... | [
[
[
"Levodopa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Teriflunomide"
]
],
[
[
"Levodopa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapsone"
],
[
... | Levodopa may cause a moderate interaction that could exacerbate diseases when taken with Dapsone and Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide
Levodopa may cause a moderate interaction that could exacerbate diseases when taken with Secnidazole and Secnidazole ... |
DB00026 | DB00687 | 1,184 | 870 | [
"DDInter94",
"DDInter747"
] | Anakinra | Fludrocortisone | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Moderate | 1 | [
[
[
1184,
24,
870
]
],
[
[
1184,
24,
1220
],
[
1220,
40,
870
]
],
[
[
1184,
24,
1586
],
[
1586,
63,
870
]
],
[
[
1184,
24,
139
],
[
139,
... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Fludrocortisone (Compound)
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Levamlodipine and Levamlodipine may cause a moderate interacti... |
DB00446 | DB08827 | 597 | 990 | [
"DDInter351",
"DDInter1085"
] | Chloramphenicol | Lomitapide | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Major | 2 | [
[
[
597,
25,
990
]
],
[
[
597,
6,
8374
],
[
8374,
45,
990
]
],
[
[
597,
21,
28658
],
[
28658,
60,
990
]
],
[
[
597,
25,
1135
],
[
1135,
... | [
[
[
"Chloramphenicol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomitapide"
]
],
[
[
"Chloramphenicol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Chloramphenicol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lomitapide (Compound)
Chloramphenicol (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Lomitapide (Compound)
Chloramphenicol may lead to a major life threatening interaction when taken with Naloxegol and Naloxeg... |
DB00867 | DB01124 | 1,052 | 1,411 | [
"DDInter1606",
"DDInter1828"
] | Ritodrine | Tolbutamide | Adrenergic beta-agonist used to control premature labor. | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
1052,
24,
1411
]
],
[
[
1052,
24,
959
],
[
959,
40,
1411
]
],
[
[
1052,
63,
245
],
[
245,
40,
1411
]
],
[
[
1052,
7,
3422
],
[
3422,
... | [
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Tolbutamide (Compound)
... |
DB01105 | DB09075 | 222 | 498 | [
"DDInter1665",
"DDInter621"
] | Sibutramine | Edoxaban | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Moderate | 1 | [
[
[
222,
24,
498
]
],
[
[
222,
25,
41
],
[
41,
24,
498
]
],
[
[
222,
64,
109
],
[
109,
24,
498
]
],
[
[
222,
24,
1017
],
[
1017,
63,... | [
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Edoxaban"
]
],
[
[
"Sibutramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Levomilnacipran"
],
[
"Levom... | Sibutramine may lead to a major life threatening interaction when taken with Levomilnacipran and Levomilnacipran may cause a moderate interaction that could exacerbate diseases when taken with Edoxaban
Sibutramine may lead to a major life threatening interaction when taken with Duloxetine and Duloxetine may cause a mod... |
DB00477 | DB01364 | 216 | 22 | [
"DDInter363",
"DDInter650"
] | Chlorpromazine | Ephedrine | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Moderate | 1 | [
[
[
216,
24,
22
]
],
[
[
216,
6,
5214
],
[
5214,
45,
22
]
],
[
[
216,
21,
28698
],
[
28698,
60,
22
]
],
[
[
216,
64,
475
],
[
475,
2... | [
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ephedrine"
]
],
[
[
"Chlorpromazine",
"{u} (Compound) binds {v} (Gene)",
"ADRA1A"
],
[
"ADRA1A",
"{u} (Gene) is bound by {v} (Comp... | Chlorpromazine (Compound) binds ADRA1A (Gene) and ADRA1A (Gene) is bound by Ephedrine (Compound)
Chlorpromazine (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Ephedrine (Compound)
Chlorpromazine may lead to a major life threatening interaction when taken with Morphine and Morphine may ... |
DB00284 | DB00988 | 1,647 | 817 | [
"DDInter11",
"DDInter584"
] | Acarbose | Dopamine | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action. | Moderate | 1 | [
[
[
1647,
24,
817
]
],
[
[
1647,
24,
532
],
[
532,
1,
817
]
],
[
[
1647,
24,
1148
],
[
1148,
63,
817
]
],
[
[
1647,
24,
874
],
[
874,
... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dopamine"
]
],
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dobutamine"
],
[
"D... | Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Dobutamine and Dobutamine (Compound) resembles Dopamine (Compound)
Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could e... |
DB00472 | DB01114 | 758 | 272 | [
"DDInter758",
"DDInter362"
] | Fluoxetine | Chlorpheniramine | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Moderate | 1 | [
[
[
758,
24,
272
]
],
[
[
758,
40,
358
],
[
358,
63,
272
]
],
[
[
758,
40,
11296
],
[
11296,
1,
272
]
],
[
[
758,
24,
849
],
[
849,
... | [
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
]
],
[
[
"Fluoxetine",
"{u} (Compound) resembles {v} (Compound)",
"Orphenadrine"
],
[
"Orphenadrine",
"{u} may cause... | Fluoxetine (Compound) resembles Orphenadrine (Compound) and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Fluoxetine (Compound) resembles Bromodiphenhydramine (Compound) and Bromodiphenhydramine (Compound) resembles Chlorpheniramine (Compound)
Fluoxetine m... |
DB00049 | DB09054 | 737 | 384 | [
"DDInter1573",
"DDInter905"
] | Rasburicase | Idelalisib | Rasburicase is a recombinant urate-oxidase enzyme produced by a genetically modified <i>Saccharomyces cerevisiae</i> strain. The cDNA coding for rasburicase was cloned from a strain of _Aspergillus flavus_. | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
737,
24,
384
]
],
[
[
737,
24,
1120
],
[
1120,
1,
33
],
[
33,
24,
384
]
],
[
[
737,
24,
290
],
[
290,
63,
1622
],
[
1622,
24,
... | [
[
[
"Rasburicase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Rasburicase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Proparacaine"
],
... | Rasburicase may cause a moderate interaction that could exacerbate diseases when taken with Proparacaine and Proparacaine (Compound) resembles Amiodarone (Compound) and Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Rasburicase may cause a moderate interaction that... |
DB00881 | DB00945 | 954 | 1,479 | [
"DDInter1554",
"DDInter20"
] | Quinapril | Acetylsalicylic acid | Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure.[L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta b... | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Moderate | 1 | [
[
[
954,
24,
1479
]
],
[
[
954,
21,
28691
],
[
28691,
60,
1479
]
],
[
[
954,
1,
1523
],
[
1523,
23,
1479
]
],
[
[
954,
23,
1283
],
[
1283,... | [
[
[
"Quinapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
]
],
[
[
"Quinapril",
"{u} (Compound) causes {v} (Side Effect)",
"Somnolence"
],
[
"Somnolence",
"{u} (Side Effec... | Quinapril (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Acetylsalicylic acid (Compound)
Quinapril (Compound) resembles Labetalol (Compound) and Labetalol may cause a minor interaction that can limit clinical effects when taken with Acetylsalicylic acid
Quinapril may cause a minor ... |
DB00445 | DB06643 | 322 | 1,136 | [
"DDInter655",
"DDInter500"
] | Epirubicin | Denosumab | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL inhibitor approved to prevent osteoclast-mediated bone loss.... | Moderate | 1 | [
[
[
322,
24,
1136
]
],
[
[
322,
24,
1213
],
[
1213,
24,
1136
]
],
[
[
322,
63,
1648
],
[
1648,
24,
1136
]
],
[
[
322,
24,
1480
],
[
1480,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Denosumab"
]
],
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
],
[
... | Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Denosumab
Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleu... |
DB00549 | DB06616 | 522 | 594 | [
"DDInter1955",
"DDInter224"
] | Zafirlukast | Bosutinib | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Moderate | 1 | [
[
[
522,
24,
594
]
],
[
[
522,
63,
883
],
[
883,
1,
594
]
],
[
[
522,
6,
8374
],
[
8374,
45,
594
]
],
[
[
522,
21,
28882
],
[
28882,
... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
]
],
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
... | Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Bosutinib (Compound)
Zafirlukast (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bosutinib (Compound)
Zafirlukast (Compound) causes Body temperature increased (Side Effec... |
DB00047 | DB09046 | 176 | 1,094 | [
"DDInter932",
"DDInter1201"
] | Insulin glargine | Metreleptin | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Metreleptin, a recombinant analog of the human hormone leptin, is an orphan drug used to treat complications of leptin deficiency in people with lipodystrophy. Lipodystrophies include a range of disorders characterized by the reduction, absence, or altered distribution of adipose tissue. Complications of lipodystrophy ... | Moderate | 1 | [
[
[
176,
24,
1094
]
],
[
[
176,
24,
168
],
[
168,
23,
1094
]
],
[
[
176,
24,
959
],
[
959,
24,
1094
]
],
[
[
176,
24,
517
],
[
517,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metreleptin"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Metreleptin
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide ... |
DB00637 | DB09420 | 1,557 | 1,074 | [
"DDInter128",
"DDInter953"
] | Astemizole | Iodide I-123 | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Moderate | 1 | [
[
[
1557,
24,
1074
]
],
[
[
1557,
23,
1247
],
[
1247,
24,
1074
]
],
[
[
1557,
25,
1487
],
[
1487,
24,
1074
]
],
[
[
1557,
24,
401
],
[
401... | [
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
]
],
[
[
"Astemizole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Astemizole may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123
Astemizole may lead to a major life threatening interaction when taken with Hydroxychloroquine and H... |
DB00978 | DB06788 | 739 | 1,616 | [
"DDInter1084",
"DDInter864"
] | Lomefloxacin | Histrelin | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Moderate | 1 | [
[
[
739,
24,
1616
]
],
[
[
739,
62,
112
],
[
112,
23,
1616
]
],
[
[
739,
24,
1342
],
[
1342,
24,
1616
]
],
[
[
739,
64,
1179
],
[
1179,
... | [
[
[
"Lomefloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histrelin"
]
],
[
[
"Lomefloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Lomefloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Lomefloxacin may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin and R... |
DB00532 | DB06691 | 208 | 849 | [
"DDInter1152",
"DDInter1155"
] | Mephenytoin | Mepyramine | Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subuni... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
208,
24,
849
]
],
[
[
208,
63,
1594
],
[
1594,
24,
849
]
],
[
[
208,
24,
272
],
[
272,
24,
849
]
],
[
[
208,
24,
407
],
[
407,
6... | [
[
[
"Mephenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Mephenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[
... | Mephenytoin may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Mephenytoin may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine an... |
DB00425 | DB04837 | 558 | 649 | [
"DDInter1970",
"DDInter407"
] | Zolpidem | Clofedanol | Zolpidem, also known as _Ambien_, is a hypnotic drug that was initially approved by the FDA in 1992 [FDA label]. Zolpidem improves sleep in patients with insomnia. It is aimed for use in patients with difficulties initiating sleep. This drug decreases the time to fall asleep (sleep latency), increases the duration of s... | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
558,
24,
649
]
],
[
[
558,
24,
1376
],
[
1376,
24,
649
]
],
[
[
558,
24,
832
],
[
832,
40,
649
]
],
[
[
558,
63,
701
],
[
701,
2... | [
[
[
"Zolpidem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Zolpidem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
[
... | Zolpidem may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Zolpidem may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine ... |
DB00252 | DB14568 | 362 | 982 | [
"DDInter1460",
"DDInter1000"
] | Phenytoin | Ivosidenib | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
362,
25,
982
]
],
[
[
362,
24,
112
],
[
112,
23,
982
]
],
[
[
362,
64,
168
],
[
168,
23,
982
]
],
[
[
362,
23,
1101
],
[
1101,
2... | [
[
[
"Phenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
"Metronida... | Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Phenytoin may lead to a major life threatening interaction when taken with Bortezomib and Bortezomib may caus... |
DB00641 | DB01611 | 467 | 1,487 | [
"DDInter1675",
"DDInter893"
] | Simvastatin | Hydroxychloroquine | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Moderate | 1 | [
[
[
467,
24,
1487
]
],
[
[
467,
6,
12523
],
[
12523,
45,
1487
]
],
[
[
467,
21,
28658
],
[
28658,
60,
1487
]
],
[
[
467,
63,
663
],
[
663,... | [
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Simvastatin",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (C... | Simvastatin (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Hydroxychloroquine (Compound)
Simvastatin (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Hydroxychloroquine (Compound)
Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Me... |
DB00850 | DB01362 | 1,630 | 497 | [
"DDInter1432",
"DDInter960"
] | Perphenazine | Iohexol | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
1630,
25,
497
]
],
[
[
1630,
18,
6929
],
[
6929,
57,
497
]
],
[
[
1630,
21,
28681
],
[
28681,
60,
497
]
],
[
[
1630,
63,
999
],
[
999,... | [
[
[
"Perphenazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Perphenazine",
"{u} (Compound) downregulates {v} (Gene)",
"ITGAE"
],
[
"ITGAE",
"{u} (Gene) is downregulated by {v} (Compound)",... | Perphenazine (Compound) downregulates ITGAE (Gene) and ITGAE (Gene) is downregulated by Iohexol (Compound)
Perphenazine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Iohexol (Compound)
Perphenazine may cause a moderate interaction that could exacerbate diseases when ta... |
DB00719 | DB01233 | 1,219 | 1,311 | [
"DDInter149",
"DDInter1197"
] | Azatadine | Metoclopramide | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Moderate | 1 | [
[
[
1219,
24,
1311
]
],
[
[
1219,
63,
1020
],
[
1020,
24,
1311
]
],
[
[
1219,
24,
643
],
[
643,
63,
1311
]
],
[
[
1219,
24,
1190
],
[
1190... | [
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
]
],
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clonidine"
],
[
... | Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Clonidine and Clonidine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide
Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Desvenlafaxine and De... |
DB00220 | DB01083 | 798 | 1,142 | [
"DDInter1276",
"DDInter1348"
] | Nelfinavir | Orlistat | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | The global prevalence of obesity is increasing rapidly. Obesity-related complications lead to significant personal and economic burden by reducing quality of life and increasing the cost of healthcare. In some individuals, diet and exercise are insufficient to maintain weight loss, and pharmacological or surgical inter... | Moderate | 1 | [
[
[
798,
24,
1142
]
],
[
[
798,
6,
8374
],
[
8374,
45,
1142
]
],
[
[
798,
18,
5833
],
[
5833,
46,
1142
]
],
[
[
798,
21,
28785
],
[
28785,... | [
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orlistat"
]
],
[
[
"Nelfinavir",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Nelfinavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Orlistat (Compound)
Nelfinavir (Compound) downregulates ACAT2 (Gene) and ACAT2 (Gene) is upregulated by Orlistat (Compound)
Nelfinavir (Compound) causes Muscle spasms (Side Effect) and Muscle spasms (Side Effect) is caused by Orlistat (Compound)
Ne... |
DB00405 | DB00454 | 128 | 1,349 | [
"DDInter517",
"DDInter1150"
] | Dexbrompheniramine | Meperidine | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration. | Moderate | 1 | [
[
[
128,
24,
1349
]
],
[
[
128,
24,
1688
],
[
1688,
1,
1349
]
],
[
[
128,
24,
100
],
[
100,
63,
1349
]
],
[
[
128,
24,
1233
],
[
1233,
... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meperidine"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenoxyla... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Diphenoxylate and Diphenoxylate (Compound) resembles Meperidine (Compound)
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a... |
DB00451 | DB01142 | 542 | 1,264 | [
"DDInter1064",
"DDInter593"
] | Levothyroxine | Doxepin | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
542,
24,
1264
]
],
[
[
542,
6,
4973
],
[
4973,
45,
1264
]
],
[
[
542,
21,
28809
],
[
28809,
60,
1264
]
],
[
[
542,
24,
463
],
[
463,
... | [
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Levothyroxine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)"... | Levothyroxine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Doxepin (Compound)
Levothyroxine (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Doxepin (Compound)
Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Rifampicin and Rif... |
DB01182 | DB14568 | 371 | 982 | [
"DDInter1534",
"DDInter1000"
] | Propafenone | Ivosidenib | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
371,
25,
982
]
],
[
[
371,
40,
271
],
[
271,
23,
982
]
],
[
[
371,
62,
112
],
[
112,
23,
982
]
],
[
[
371,
24,
976
],
[
976,
24,... | [
[
[
"Propafenone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Propafenone",
"{u} (Compound) resembles {v} (Compound)",
"Mirabegron"
],
[
"Mirabegron",
"{u} may cause a minor interaction th... | Propafenone (Compound) resembles Mirabegron (Compound) and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Propafenone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can ... |
DB00519 | DB01284 | 1,638 | 1,042 | [
"DDInter1843",
"DDInter1782"
] | Trandolapril | Tetracosactide | Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiote... | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Moderate | 1 | [
[
[
1638,
24,
1042
]
],
[
[
1638,
24,
761
],
[
761,
63,
1042
]
],
[
[
1638,
35,
1144
],
[
1144,
24,
1042
]
],
[
[
1638,
1,
610
],
[
610,
... | [
[
[
"Trandolapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
]
],
[
[
"Trandolapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
],... | Trandolapril may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin and Saxagliptin may cause a moderate interaction that could exacerbate diseases when taken with Tetracosactide
Trandolapril (Compound) resembles Nateglinide (Compound) and Trandolapril may cause a moderate interacti... |
DB00327 | DB01362 | 421 | 497 | [
"DDInter890",
"DDInter960"
] | Hydromorphone | Iohexol | Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of [morphine] that has been available clinically since 1920. Structurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 a... | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
421,
25,
497
]
],
[
[
421,
21,
29750
],
[
29750,
60,
497
]
],
[
[
421,
24,
999
],
[
999,
25,
497
]
],
[
[
421,
1,
314
],
[
314,
... | [
[
[
"Hydromorphone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Hydromorphone",
"{u} (Compound) causes {v} (Side Effect)",
"Injection site pain"
],
[
"Injection site pain",
"{u} (Side Effect)... | Hydromorphone (Compound) causes Injection site pain (Side Effect) and Injection site pain (Side Effect) is caused by Iohexol (Compound)
Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine and Thiethylperazine may lead to a major life threatening interaction whe... |
DB00241 | DB00603 | 288 | 303 | [
"DDInter257",
"DDInter1137"
] | Butalbital | Medroxyprogesterone acetate | Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervou... | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Moderate | 1 | [
[
[
288,
24,
303
]
],
[
[
288,
24,
167
],
[
167,
1,
303
]
],
[
[
288,
24,
888
],
[
888,
62,
303
]
],
[
[
288,
24,
1478
],
[
1478,
63... | [
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Medroxyprogesterone acetate"
]
],
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocorti... | Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Medroxyprogesterone acetate (Compound)
Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen may cause a minor in... |
DB01276 | DB13985 | 123 | 546 | [
"DDInter706",
"DDInter1108"
] | Exenatide | Lutetium Lu 177 dotatate | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | A 177Lu-labeled somatostatin analog peptide, Lutetium Lu 177 dotatate belongs to an emerging form of treatments called Peptide Receptor Radionuclide Therapy (PRRT), which involves targeting tumours with molecules carrying radioactive particles that bind to specific receptors expressed by the tumour. Lutetium Lu 177 dot... | Moderate | 1 | [
[
[
123,
24,
546
]
],
[
[
123,
63,
50
],
[
50,
24,
546
]
],
[
[
123,
24,
4
],
[
4,
24,
546
]
],
[
[
123,
63,
629
],
[
629,
25,
... | [
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lutetium Lu 177 dotatate"
]
],
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfasalazine"
... | Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Sulfasalazine and Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Lutetium Lu 177 dotatate
Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Oma... |
DB00851 | DB16627 | 611 | 1,125 | [
"DDInter463",
"DDInter1145"
] | Dacarbazine | Melphalan flufenamide | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | Melphalan flufenamide, also known as melflufen or J1, is a prodrug of [melphalan].[A230123,L32173] Melphalan flufenamide is more readily uptaken by cells than melphalan, and is cleaved to the active metabolite by aminopeptidases. _In vitro_ models show that melphalan is 10 to hundreds of times more potent than melphala... | Moderate | 1 | [
[
[
611,
24,
1125
]
],
[
[
611,
63,
147
],
[
147,
24,
1125
]
],
[
[
611,
24,
1224
],
[
1224,
24,
1125
]
],
[
[
611,
63,
147
],
[
147,
... | [
[
[
"Dacarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Melphalan flufenamide"
]
],
[
[
"Dacarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinblastine"
... | Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Melphalan flufenamide
Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Cytara... |
DB00352 | DB14711 | 482 | 779 | [
"DDInter1814",
"DDInter1680"
] | Tioguanine | Smallpox (Vaccinia) Vaccine, Live | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | The New York City Board of Health strain of _Vaccinia_ is a viral strain used as a component of some smallpox vaccinations. ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this strain. | Major | 2 | [
[
[
482,
25,
779
]
],
[
[
482,
64,
1064
],
[
1064,
25,
779
]
],
[
[
482,
24,
478
],
[
478,
25,
779
]
],
[
[
482,
25,
1377
],
[
1377,
... | [
[
[
"Tioguanine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Smallpox (Vaccinia) Vaccine, Live"
]
],
[
[
"Tioguanine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[
"Cl... | Tioguanine may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Smallpox (Vaccinia) Vaccine, Live
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may ... |
DB01200 | DB01246 | 469 | 820 | [
"DDInter243",
"DDInter45"
] | Bromocriptine | Alimemazine | Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. It inhibits prolactin secretion and may be used to treat dysfunctions associated with hyperprolactinemia. Bromocriptine is also indicated for the management of signs and symptoms of Parkinsonian Syndrome, as well as t... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
469,
24,
820
]
],
[
[
469,
63,
104
],
[
104,
40,
820
]
],
[
[
469,
63,
401
],
[
401,
24,
820
]
],
[
[
469,
24,
649
],
[
649,
1,
... | [
[
[
"Bromocriptine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Bromocriptine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],... | Bromocriptine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (Compound)
Bromocriptine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interac... |
DB00661 | DB08912 | 122 | 1,040 | [
"DDInter1928",
"DDInter462"
] | Verapamil | Dabrafenib | Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
122,
24,
1040
]
],
[
[
122,
6,
4973
],
[
4973,
45,
1040
]
],
[
[
122,
7,
15855
],
[
15855,
46,
1040
]
],
[
[
122,
21,
28779
],
[
28779... | [
[
[
"Verapamil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Verapamil",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Verapamil (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dabrafenib (Compound)
Verapamil (Compound) upregulates SESN1 (Gene) and SESN1 (Gene) is upregulated by Dabrafenib (Compound)
Verapamil (Compound) causes Dry mouth (Side Effect) and Dry mouth (Side Effect) is caused by Dabrafenib (Compound)
Verapamil m... |
DB00549 | DB09074 | 522 | 1,362 | [
"DDInter1955",
"DDInter1327"
] | Zafirlukast | Olaparib | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
522,
24,
1362
]
],
[
[
522,
24,
896
],
[
896,
24,
1362
]
],
[
[
522,
63,
588
],
[
588,
24,
1362
]
],
[
[
522,
24,
1619
],
[
1619,
... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
],
[
... | Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Methylergometrine and M... |
DB06694 | DB09080 | 31 | 144 | [
"DDInter1952",
"DDInter1331"
] | Xylometazoline (nasal) | Olodaterol | Xylometazoline is an alkylbenzene. | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
31,
24,
144
]
],
[
[
31,
63,
1290
],
[
1290,
24,
144
]
],
[
[
31,
24,
1663
],
[
1663,
63,
144
]
],
[
[
31,
24,
41
],
[
41,
24,
... | [
[
[
"Xylometazoline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Xylometazoline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midodrine"
],
... | Xylometazoline may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Xylometazoline may cause a moderate interaction that could exacerbate diseases when taken with Midodrine and Midodrine may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Xylo... |
DB00635 | DB01174 | 1,573 | 697 | [
"DDInter1515",
"DDInter1442"
] | Prednisone | Phenobarbital | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Moderate | 1 | [
[
[
1573,
24,
697
]
],
[
[
1573,
24,
759
],
[
759,
1,
697
]
],
[
[
1573,
63,
362
],
[
362,
1,
697
]
],
[
[
1573,
63,
536
],
[
536,
4... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenobarbital"
]
],
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
],
[
... | Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone (Compound) resembles Phenobarbital (Compound)
Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Phenobarbital (Compound... |
DB01024 | DB01357 | 1,096 | 890 | [
"DDInter1252",
"DDInter1160"
] | Mycophenolic acid | Mestranol | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | The 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives. | Major | 2 | [
[
[
1096,
25,
890
]
],
[
[
1096,
64,
1197
],
[
1197,
40,
890
]
],
[
[
1096,
7,
5415
],
[
5415,
46,
890
]
],
[
[
1096,
63,
1572
],
[
1572,
... | [
[
[
"Mycophenolic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mestranol"
]
],
[
[
"Mycophenolic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Norethisterone"
],
[
"Norethis... | Mycophenolic acid may lead to a major life threatening interaction when taken with Norethisterone and Norethisterone (Compound) resembles Mestranol (Compound)
Mycophenolic acid (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Mestranol (Compound)
Mycophenolic acid may cause a moderate interactio... |
DB00738 | DB12825 | 485 | 1,375 | [
"DDInter1420",
"DDInter1032"
] | Pentamidine | Lefamulin | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Major | 2 | [
[
[
485,
25,
1375
]
],
[
[
485,
23,
112
],
[
112,
23,
1375
]
],
[
[
485,
64,
1101
],
[
1101,
24,
1375
]
],
[
[
485,
24,
659
],
[
659,
... | [
[
[
"Pentamidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lefamulin"
]
],
[
[
"Pentamidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronid... | Pentamidine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lefamulin
Pentamidine may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cau... |
DB00065 | DB01115 | 581 | 336 | [
"DDInter923",
"DDInter1291"
] | Infliximab | Nifedipine | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Moderate | 1 | [
[
[
581,
24,
336
]
],
[
[
581,
24,
1428
],
[
1428,
1,
336
]
],
[
[
581,
24,
1081
],
[
1081,
40,
336
]
],
[
[
581,
24,
1031
],
[
1031,
... | [
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nifedipine"
]
],
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isradipine"
],
[
... | Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradipine (Compound) resembles Nifedipine (Compound)
Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Nicardipine and Nicardipine (Compound) resembles Nifedipine (Compound... |
DB00005 | DB12001 | 1,057 | 564 | [
"DDInter687",
"DDInter7"
] | Etanercept | Abemaciclib | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Major | 2 | [
[
[
1057,
25,
564
]
],
[
[
1057,
24,
748
],
[
748,
24,
564
]
],
[
[
1057,
25,
259
],
[
259,
24,
564
]
],
[
[
1057,
24,
151
],
[
151,
... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Abemaciclib"
]
],
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
],
[
"Anth... | Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine and Anthrax vaccine may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Etanercept may lead to a major life threatening interaction when taken with Rilonacept and Rilonacept... |
DB01324 | DB09038 | 178 | 1,450 | [
"DDInter1490",
"DDInter636"
] | Polythiazide | Empagliflozin | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
178,
24,
1450
]
],
[
[
178,
24,
659
],
[
659,
63,
1450
]
],
[
[
178,
63,
1061
],
[
1061,
24,
1450
]
],
[
[
178,
1,
323
],
[
323,
... | [
[
[
"Polythiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Polythiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
],
... | Polythiazide may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Polythiazide may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil a... |
DB06605 | DB15035 | 1,409 | 503 | [
"DDInter108",
"DDInter1959"
] | Apixaban | Zanubrutinib | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Major | 2 | [
[
[
1409,
25,
503
]
],
[
[
1409,
24,
982
],
[
982,
24,
503
]
],
[
[
1409,
63,
222
],
[
222,
24,
503
]
],
[
[
1409,
64,
39
],
[
39,
2... | [
[
[
"Apixaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Apixaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivosidenib"
],
[
"Ivosidenib",... | Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Ivosidenib and Ivosidenib may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutra... |
DB00500 | DB08816 | 24 | 578 | [
"DDInter1831",
"DDInter1802"
] | Tolmetin | Ticagrelor | A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin. | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
24,
24,
578
]
],
[
[
24,
21,
28762
],
[
28762,
60,
578
]
],
[
[
24,
63,
1578
],
[
1578,
24,
578
]
],
[
[
24,
64,
1172
],
[
1172,
... | [
[
[
"Tolmetin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Tolmetin",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is caused by ... | Tolmetin (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Ticagrelor (Compound)
Tolmetin may cause a moderate interaction that could exacerbate diseases when taken with Lepirudin and Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor
Tolm... |
DB00911 | DB15982 | 458 | 1,339 | [
"DDInter1811",
"DDInter193"
] | Tinidazole | Berotralstat | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat ... | Moderate | 1 | [
[
[
458,
24,
1339
]
],
[
[
458,
63,
1101
],
[
1101,
23,
1339
]
],
[
[
458,
24,
283
],
[
283,
23,
1339
]
],
[
[
458,
24,
351
],
[
351,
... | [
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Berotralstat"
]
],
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Berotralstat
Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedrat... |
DB00434 | DB01068 | 13 | 1,565 | [
"DDInter459",
"DDInter411"
] | Cyproheptadine | Clonazepam | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop.[FDA Label][L5572,F3763,F3787,F3796] The agent has also been indicated for treating panic disorder.[FDA Label][A175438,L5572,F3763,F3787,F3796] The mechan... | Moderate | 1 | [
[
[
13,
24,
1565
]
],
[
[
13,
24,
1382
],
[
1382,
1,
1565
]
],
[
[
13,
24,
1216
],
[
1216,
40,
1565
]
],
[
[
13,
74,
695
],
[
695,
4... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clonazepam"
]
],
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midazolam"
],
... | Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Midazolam and Midazolam (Compound) resembles Clonazepam (Compound)
Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Flurazepam and Flurazepam (Compound) resembles Clonazepam (Comp... |
DB08907 | DB08931 | 1,344 | 947 | [
"DDInter280",
"DDInter1600"
] | Canagliflozin | Riociguat | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Riociguat is a soluble guanylate cyclase (sGC) agonist approved in the USA, Europe and several other regions for patients with group I PAH (pulmonary arterial hypertension) in WHO FC II or III; and for the treatment of patients with inoperable CTEPH (chronic thromboembolic pulmonary hypertension), or persistent/recurre... | Moderate | 1 | [
[
[
1344,
24,
947
]
],
[
[
1344,
63,
609
],
[
609,
24,
947
]
],
[
[
1344,
24,
1455
],
[
1455,
63,
947
]
],
[
[
1344,
40,
549
],
[
549,
... | [
[
[
"Canagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Riociguat"
]
],
[
[
"Canagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
],... | Canagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Riociguat
Canagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Nitrous ... |
DB00465 | DB00585 | 886 | 1,127 | [
"DDInter1010",
"DDInter1309"
] | Ketorolac | Nizatidine | Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, men... | A histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers. | Minor | 0 | [
[
[
886,
23,
1127
]
],
[
[
886,
23,
1194
],
[
1194,
40,
1127
]
],
[
[
886,
7,
2216
],
[
2216,
46,
1127
]
],
[
[
886,
6,
7720
],
[
7720,
... | [
[
[
"Ketorolac",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Nizatidine"
]
],
[
[
"Ketorolac",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ranitidine"
],
[
"R... | Ketorolac may cause a minor interaction that can limit clinical effects when taken with Ranitidine and Ranitidine (Compound) resembles Nizatidine (Compound)
Ketorolac (Compound) upregulates PAK1 (Gene) and PAK1 (Gene) is upregulated by Nizatidine (Compound)
Ketorolac (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is up... |
DB00619 | DB00872 | 1,419 | 1,080 | [
"DDInter909",
"DDInter438"
] | Imatinib | Conivaptan | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Moderate | 1 | [
[
[
1419,
24,
1080
]
],
[
[
1419,
24,
165
],
[
165,
40,
1080
]
],
[
[
1419,
25,
990
],
[
990,
40,
1080
]
],
[
[
1419,
6,
8374
],
[
8374,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Conivaptan"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolvaptan"
],
[
"... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Tolvaptan and Tolvaptan (Compound) resembles Conivaptan (Compound)
Imatinib may lead to a major life threatening interaction when taken with Lomitapide and Lomitapide (Compound) resembles Conivaptan (Compound)
Imatinib (Compound) b... |
DB01069 | DB04837 | 401 | 649 | [
"DDInter1533",
"DDInter407"
] | Promethazine | Clofedanol | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
401,
24,
649
]
],
[
[
401,
24,
1376
],
[
1376,
24,
649
]
],
[
[
401,
74,
21
],
[
21,
24,
649
]
],
[
[
401,
63,
1405
],
[
1405,
2... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],... | Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Promethazine (Compound) resembles Amitriptyline (Compound) and Promethazine may cause a moderate int... |
DB00762 | DB08820 | 613 | 1,478 | [
"DDInter973",
"DDInter997"
] | Irinotecan | Ivacaftor | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
613,
24,
1478
]
],
[
[
613,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
613,
21,
28762
],
[
28762,
60,
1478
]
],
[
[
613,
63,
307
],
[
307,
... | [
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Irinotecan",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Irinotecan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Irinotecan (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Ivacaftor (Compound)
Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil... |
DB00776 | DB01501 | 1,335 | 1,118 | [
"DDInter1360",
"DDInter549"
] | Oxcarbazepine | Difenoxin | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Difenoxin is a 4-phenylpiperidine which is closely related to the opioid analgesic meperidine. Difenoxin alone is a USA Schedule I controlled drug, as it may be habit forming. However, it is listed as a Schedule IV controlled drug if combined with atropine, which is added to decrease deliberate misuse. Motofen(R) is a ... | Moderate | 1 | [
[
[
1335,
24,
1118
]
],
[
[
1335,
24,
1688
],
[
1688,
40,
1118
]
],
[
[
1335,
63,
506
],
[
506,
24,
1118
]
],
[
[
1335,
1,
902
],
[
902,
... | [
[
[
"Oxcarbazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Difenoxin"
]
],
[
[
"Oxcarbazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenoxylate"
],
... | Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when taken with Diphenoxylate and Diphenoxylate (Compound) resembles Difenoxin (Compound)
Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan and Dextromethorphan may cause a moderate... |
DB00321 | DB01087 | 21 | 1,520 | [
"DDInter78",
"DDInter1520"
] | Amitriptyline | Primaquine | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Moderate | 1 | [
[
[
21,
24,
1520
]
],
[
[
21,
25,
1487
],
[
1487,
64,
1520
]
],
[
[
21,
6,
12523
],
[
12523,
45,
1520
]
],
[
[
21,
21,
28722
],
[
28722,
... | [
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
]
],
[
[
"Amitriptyline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
],
[
... | Amitriptyline may lead to a major life threatening interaction when taken with Hydroxychloroquine and Hydroxychloroquine may lead to a major life threatening interaction when taken with Primaquine
Amitriptyline (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Primaquine (Compound)
Amitriptyline (Compound) c... |
DB00995 | DB08865 | 1,112 | 1,593 | [
"DDInter139",
"DDInter448"
] | Auranofin | Crizotinib | Auranofin is a gold salt that is capable of eliciting pharmacologic actions that suppress inflammation and stimulate cell-mediated immunity. It has subsequently been listed by the World Health Organization as a member of the antirheumatic agent category. Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA. Heme ox... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Moderate | 1 | [
[
[
1112,
24,
1593
]
],
[
[
1112,
18,
2900
],
[
2900,
46,
1593
]
],
[
[
1112,
7,
7478
],
[
7478,
46,
1593
]
],
[
[
1112,
18,
10375
],
[
10... | [
[
[
"Auranofin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
]
],
[
[
"Auranofin",
"{u} (Compound) downregulates {v} (Gene)",
"NFKBIA"
],
[
"NFKBIA",
"{u} (Gene) is upregulated by {v} ... | Auranofin (Compound) downregulates NFKBIA (Gene) and NFKBIA (Gene) is upregulated by Crizotinib (Compound)
Auranofin (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Crizotinib (Compound)
Auranofin (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Crizotinib (Compo... |
DB00673 | DB00712 | 723 | 1,274 | [
"DDInter112",
"DDInter763"
] | Aprepitant | Flurbiprofen | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Moderate | 1 | [
[
[
723,
24,
1274
]
],
[
[
723,
6,
6017
],
[
6017,
45,
1274
]
],
[
[
723,
21,
28769
],
[
28769,
60,
1274
]
],
[
[
723,
63,
752
],
[
752,
... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
]
],
[
[
"Aprepitant",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)... | Aprepitant (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Flurbiprofen (Compound)
Aprepitant (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Flurbiprofen (Compound)
Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with C... |
DB00581 | DB06699 | 355 | 774 | [
"DDInter1018",
"DDInter493"
] | Lactulose | Degarelix | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Moderate | 1 | [
[
[
355,
24,
774
]
],
[
[
355,
63,
521
],
[
521,
1,
774
]
],
[
[
355,
21,
28722
],
[
28722,
60,
774
]
],
[
[
355,
24,
956
],
[
956,
... | [
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Degarelix"
]
],
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Goserelin"
],
[
... | Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin (Compound) resembles Degarelix (Compound)
Lactulose (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Degarelix (Compound)
Lactulose may cause a moderate interaction that could ex... |
DB00022 | DB01156 | 268 | 593 | [
"DDInter1408",
"DDInter252"
] | Peginterferon alfa-2b | Bupropion | Peginterferon alfa-2b is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Major | 2 | [
[
[
268,
25,
593
]
],
[
[
268,
24,
996
],
[
996,
63,
593
]
],
[
[
268,
24,
126
],
[
126,
24,
593
]
],
[
[
268,
23,
450
],
[
450,
24,... | [
[
[
"Peginterferon alfa-2b",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bupropion"
]
],
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bedaquiline"
],
... | Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Bedaquiline and Bedaquiline may cause a moderate interaction that could exacerbate diseases when taken with Bupropion
Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00631 | DB00861 | 372 | 914 | [
"DDInter405",
"DDInter551"
] | Clofarabine | Diflunisal | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | Moderate | 1 | [
[
[
372,
24,
914
]
],
[
[
372,
24,
712
],
[
712,
63,
914
]
],
[
[
372,
7,
7720
],
[
7720,
45,
914
]
],
[
[
372,
21,
29209
],
[
29209,
... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diflunisal"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olsalazine"
],
[
... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Olsalazine and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Diflunisal
Clofarabine (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Diflunisal (Compound)
Clofarabine ... |
DB08820 | DB12010 | 1,478 | 214 | [
"DDInter997",
"DDInter785"
] | Ivacaftor | Fostamatinib | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
1478,
24,
214
]
],
[
[
1478,
63,
1428
],
[
1428,
24,
214
]
],
[
[
1478,
64,
723
],
[
723,
24,
214
]
],
[
[
1478,
24,
861
],
[
861,
... | [
[
[
"Ivacaftor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Ivacaftor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isradipine"
],
[
... | Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradipine may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Ivacaftor may lead to a major life threatening interaction when taken with Aprepitant and Aprepitant may cause ... |
DB00446 | DB01024 | 597 | 1,096 | [
"DDInter351",
"DDInter1252"
] | Chloramphenicol | Mycophenolic acid | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Moderate | 1 | [
[
[
597,
24,
1096
]
],
[
[
597,
24,
955
],
[
955,
1,
1096
]
],
[
[
597,
7,
2329
],
[
2329,
46,
1096
]
],
[
[
597,
18,
10780
],
[
10780,
... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolic acid"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenol... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolate mofetil and Mycophenolate mofetil (Compound) resembles Mycophenolic acid (Compound)
Chloramphenicol (Compound) upregulates UBE2L6 (Gene) and UBE2L6 (Gene) is upregulated by Mycophenolic acid (Compound)
Chloramp... |
DB00451 | DB01359 | 542 | 729 | [
"DDInter1064",
"DDInter1417"
] | Levothyroxine | Penbutolol | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Penbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergic receptors, since it is a sympathomimetric drug. Penbutolol also demonstrates high... | Minor | 0 | [
[
[
542,
23,
729
]
],
[
[
542,
62,
461
],
[
461,
1,
729
]
],
[
[
542,
23,
699
],
[
699,
40,
729
]
],
[
[
542,
21,
28698
],
[
28698,
... | [
[
[
"Levothyroxine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Penbutolol"
]
],
[
[
"Levothyroxine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Timolol"
],
[
... | Levothyroxine may cause a minor interaction that can limit clinical effects when taken with Timolol and Timolol (Compound) resembles Penbutolol (Compound)
Levothyroxine may cause a minor interaction that can limit clinical effects when taken with Nadolol and Nadolol (Compound) resembles Penbutolol (Compound)
Levothyrox... |
DB00687 | DB00816 | 870 | 1,674 | [
"DDInter747",
"DDInter1346"
] | Fludrocortisone | Orciprenaline | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Minor | 0 | [
[
[
870,
23,
1674
]
],
[
[
870,
21,
28845
],
[
28845,
60,
1674
]
],
[
[
870,
1,
251
],
[
251,
23,
1674
]
],
[
[
870,
1,
891
],
[
891,
... | [
[
[
"Fludrocortisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Orciprenaline"
]
],
[
[
"Fludrocortisone",
"{u} (Compound) causes {v} (Side Effect)",
"Oedema"
],
[
"Oedema",
"{u} (Side Effect) is... | Fludrocortisone (Compound) causes Oedema (Side Effect) and Oedema (Side Effect) is caused by Orciprenaline (Compound)
Fludrocortisone (Compound) resembles Betamethasone (Compound) and Betamethasone may cause a minor interaction that can limit clinical effects when taken with Orciprenaline
Fludrocortisone (Compound) res... |
DB06674 | DB11952 | 908 | 800 | [
"DDInter837",
"DDInter612"
] | Golimumab | Duvelisib | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Major | 2 | [
[
[
908,
25,
800
]
],
[
[
908,
25,
310
],
[
310,
24,
800
]
],
[
[
908,
63,
467
],
[
467,
24,
800
]
],
[
[
908,
25,
1476
],
[
1476,
6... | [
[
[
"Golimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Duvelisib"
]
],
[
[
"Golimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabazitaxel"
],
[
"Cabazitaxel",
"{u} ma... | Golimumab may lead to a major life threatening interaction when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib
Golimumab may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvastatin may cause... |
DB00983 | DB01142 | 480 | 1,264 | [
"DDInter776",
"DDInter593"
] | Formoterol | Doxepin | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
480,
24,
1264
]
],
[
[
480,
63,
508
],
[
508,
24,
1264
]
],
[
[
480,
24,
401
],
[
401,
24,
1264
]
],
[
[
480,
6,
6017
],
[
6017,
... | [
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promazine"
],
[
... | Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethaz... |
DB04908 | DB09073 | 1,671 | 951 | [
"DDInter741",
"DDInter1379"
] | Flibanserin | Palbociclib | Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder... | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Moderate | 1 | [
[
[
1671,
24,
951
]
],
[
[
1671,
24,
159
],
[
159,
63,
951
]
],
[
[
1671,
63,
134
],
[
134,
24,
951
]
],
[
[
1671,
25,
283
],
[
283,
... | [
[
[
"Flibanserin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
]
],
[
[
"Flibanserin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
... | Flibanserin may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib
Flibanserin may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine ... |
DB00352 | DB01050 | 482 | 848 | [
"DDInter1814",
"DDInter900"
] | Tioguanine | Ibuprofen | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Moderate | 1 | [
[
[
482,
24,
848
]
],
[
[
482,
24,
1307
],
[
1307,
1,
848
]
],
[
[
482,
6,
9320
],
[
9320,
45,
848
]
],
[
[
482,
21,
28868
],
[
28868,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Melphalan"
],
[
... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Melphalan and Melphalan (Compound) resembles Ibuprofen (Compound)
Tioguanine (Compound) binds ABCC4 (Gene) and ABCC4 (Gene) is bound by Ibuprofen (Compound)
Tioguanine (Compound) causes Stomatitis (Side Effect) and Stomatitis (Si... |
DB06616 | DB09039 | 594 | 1,670 | [
"DDInter224",
"DDInter629"
] | Bosutinib | Eliglustat | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Moderate | 1 | [
[
[
594,
24,
1670
]
],
[
[
594,
63,
479
],
[
479,
23,
1670
]
],
[
[
594,
63,
839
],
[
839,
24,
1670
]
],
[
[
594,
24,
943
],
[
943,
... | [
[
[
"Bosutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eliglustat"
]
],
[
[
"Bosutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
],
[
... | Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepezil may cause a minor interaction that can limit clinical effects when taken with Eliglustat
Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Grepafloxacin and Grepaflox... |
DB01001 | DB01118 | 688 | 33 | [
"DDInter1632",
"DDInter76"
] | Salbutamol | Amiodarone | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Moderate | 1 | [
[
[
688,
24,
33
]
],
[
[
688,
24,
540
],
[
540,
1,
33
]
],
[
[
688,
6,
1704
],
[
1704,
45,
33
]
],
[
[
688,
21,
28779
],
[
28779,
60... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiodarone"
]
],
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronedarone"
],
[
... | Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Dronedarone and Dronedarone (Compound) resembles Amiodarone (Compound)
Salbutamol (Compound) binds ADRB1 (Gene) and ADRB1 (Gene) is bound by Amiodarone (Compound)
Salbutamol (Compound) causes Dry mouth (Side Effect) and Dry mouth... |
DB00631 | DB09498 | 372 | 810 | [
"DDInter405",
"DDInter1715"
] | Clofarabine | Strontium chloride Sr-89 | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Moderate | 1 | [
[
[
372,
24,
810
]
],
[
[
372,
63,
552
],
[
552,
24,
810
]
],
[
[
372,
35,
1224
],
[
1224,
24,
810
]
],
[
[
372,
24,
304
],
[
304,
2... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Strontium chloride Sr-89"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carmustine"... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Carmustine and Carmustine may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89
Clofarabine (Compound) resembles Cytarabine (Compound) and Clofarabine may cause a moderate inter... |
DB00390 | DB00860 | 1,252 | 891 | [
"DDInter554",
"DDInter1513"
] | Digoxin | Prednisolone | Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also known as the _Digi... | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Moderate | 1 | [
[
[
1252,
24,
891
]
],
[
[
1252,
24,
175
],
[
175,
40,
891
]
],
[
[
1252,
24,
167
],
[
167,
1,
891
]
],
[
[
1252,
7,
1899
],
[
1899,
... | [
[
[
"Digoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisolone"
]
],
[
[
"Digoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],
[
... | Digoxin may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Prednisolone (Compound)
Digoxin may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Prednisolone... |
DB00439 | DB11837 | 289 | 1,297 | [
"DDInter341",
"DDInter1351"
] | Cerivastatin | Osilodrostat | On August 8, 2001 the U.S. Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew Baycol from the U.S. market, due to reports of fatal rhabdomyolysis, a severe adverse reaction from this cholesterol-lowering (lipid-lowering) product. It has also been withdrawn from the Cana... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
289,
24,
1297
]
],
[
[
289,
24,
112
],
[
112,
23,
1297
]
],
[
[
289,
24,
466
],
[
466,
62,
1297
]
],
[
[
289,
24,
578
],
[
578,
... | [
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],... | Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Darolutamid... |
DB00371 | DB01181 | 1,050 | 1,532 | [
"DDInter1154",
"DDInter906"
] | Meprobamate | Ifosfamide | A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (... | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
1050,
24,
1532
]
],
[
[
1050,
6,
10215
],
[
10215,
45,
1532
]
],
[
[
1050,
21,
28956
],
[
28956,
60,
1532
]
],
[
[
1050,
63,
1648
],
[
... | [
[
[
"Meprobamate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Meprobamate",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compoun... | Meprobamate (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Ifosfamide (Compound)
Meprobamate (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Ifosfamide (Compound)
Meprobamate may cause a moderate interaction that could exacerbate diseases when taken with Aldesleu... |
DB00590 | DB01143 | 1,433 | 923 | [
"DDInter592",
"DDInter65"
] | Doxazosin | Amifostine | Doxazosin is an alpha-1 antagonist used for the treatment of benign prostatic hypertrophy (BPH) symptoms and hypertension. Other members of this drug class include [Prazosin], [Terazosin], [Tamsulosin], and [Alfuzosin]. Because of its long-lasting effects, doxazosin can be administered once a day. It is marketed by Pfi... | A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia. | Moderate | 1 | [
[
[
1433,
24,
923
]
],
[
[
1433,
21,
28642
],
[
28642,
60,
923
]
],
[
[
1433,
1,
1205
],
[
1205,
24,
923
]
],
[
[
1433,
24,
714
],
[
714,
... | [
[
[
"Doxazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amifostine"
]
],
[
[
"Doxazosin",
"{u} (Compound) causes {v} (Side Effect)",
"Shock"
],
[
"Shock",
"{u} (Side Effect) is caused by {v} ... | Doxazosin (Compound) causes Shock (Side Effect) and Shock (Side Effect) is caused by Amifostine (Compound)
Doxazosin (Compound) resembles Prazosin (Compound) and Prazosin may cause a moderate interaction that could exacerbate diseases when taken with Amifostine
Doxazosin may cause a moderate interaction that could exac... |
DB00023 | DB00812 | 305 | 998 | [
"DDInter127",
"DDInter1451"
] | Asparaginase Escherichia coli | Phenylbutazone | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Moderate | 1 | [
[
[
305,
24,
998
]
],
[
[
305,
24,
362
],
[
362,
1,
998
]
],
[
[
305,
24,
97
],
[
97,
40,
998
]
],
[
[
305,
24,
168
],
[
168,
23,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylbutazone"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken wit... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Phenylbutazone (Compound)
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Oxaprozin and Oxaprozin (Comp... |
DB00341 | DB00850 | 1,242 | 1,630 | [
"DDInter343",
"DDInter1432"
] | Cetirizine | Perphenazine | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Moderate | 1 | [
[
[
1242,
24,
1630
]
],
[
[
1242,
35,
252
],
[
252,
40,
1630
]
],
[
[
1242,
1,
1321
],
[
1321,
40,
1630
]
],
[
[
1242,
24,
508
],
[
508,
... | [
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perphenazine"
]
],
[
[
"Cetirizine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken... | Cetirizine (Compound) resembles Hydroxyzine (Compound) and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyzine and Hydroxyzine (Compound) resembles Perphenazine (Compound)
Cetirizine (Compound) resembles Prochlorperazine (Compound) and Prochlorperazine (Compound) resem... |
DB00307 | DB14761 | 1,101 | 242 | [
"DDInter202",
"DDInter1578"
] | Bexarotene | Remdesivir | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends o... | Moderate | 1 | [
[
[
1101,
24,
242
]
],
[
[
1101,
24,
1130
],
[
1130,
24,
242
]
],
[
[
1101,
25,
1377
],
[
1377,
24,
242
]
],
[
[
1101,
64,
367
],
[
367,
... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitazone"
],
[
... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Pioglitazone and Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir
Bexarotene may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may ... |
DB00331 | DB01577 | 1,645 | 1,529 | [
"DDInter1164",
"DDInter1161"
] | Metformin | Metamfetamine | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Metamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug, and a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. It is a scheduled drug in most countries due to its high potentia... | Moderate | 1 | [
[
[
1645,
24,
1529
]
],
[
[
1645,
24,
939
],
[
939,
40,
1529
]
],
[
[
1645,
24,
22
],
[
22,
24,
1529
]
],
[
[
1645,
24,
1039
],
[
1039,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metamfetamine"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzphetamine"
],
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Benzphetamine and Benzphetamine (Compound) resembles Metamfetamine (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine and Ephedrine may cause a moderate interaction that ... |
DB09039 | DB12035 | 1,670 | 943 | [
"DDInter629",
"DDInter1641"
] | Eliglustat | Sarecycline | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Sarecycline is a semi-synthetic derivative of tetracycline that was initially discovered by Paratek Pharmaceuticals from Boston, MA but then licensed to Warner Chilcott of Rockaway, NJ in July of 2007 . After completing various phase-II and phase-III trials demonstrating its effectiveness in treating moderate to severe... | Moderate | 1 | [
[
[
1670,
24,
943
]
],
[
[
1670,
23,
1135
],
[
1135,
23,
943
]
],
[
[
1670,
63,
1181
],
[
1181,
24,
943
]
],
[
[
1670,
25,
1456
],
[
1456,... | [
[
[
"Eliglustat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarecycline"
]
],
[
[
"Eliglustat",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Eliglustat may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Sarecycline
Eliglustat may cause a moderate interaction that could exacerbate diseases when taken with Terfenadine and Terfenadin... |
DB01058 | DB01174 | 978 | 697 | [
"DDInter1510",
"DDInter1442"
] | Praziquantel | Phenobarbital | Praziquantel is a pyrazino-isoquinolein derivative from the thioxantonic group used as a broad anthelmintic spectrum. Specifically, it is known as a treatment of trematodes and cestodes infections such as schistosomiasis, taeniasis, and cysticercosis. The efficacy of praziquantel in treating parasitic flatworms infecti... | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Major | 2 | [
[
[
978,
25,
697
]
],
[
[
978,
64,
759
],
[
759,
1,
697
]
],
[
[
978,
63,
536
],
[
536,
40,
697
]
],
[
[
978,
63,
1023
],
[
1023,
1,... | [
[
[
"Praziquantel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phenobarbital"
]
],
[
[
"Praziquantel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Primidone"
],
[
"Primidone",
"... | Praziquantel may lead to a major life threatening interaction when taken with Primidone and Primidone (Compound) resembles Phenobarbital (Compound)
Praziquantel may cause a moderate interaction that could exacerbate diseases when taken with Secobarbital and Secobarbital (Compound) resembles Phenobarbital (Compound)
Pra... |
DB00023 | DB00564 | 305 | 1,236 | [
"DDInter127",
"DDInter293"
] | Asparaginase Escherichia coli | Carbamazepine | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Moderate | 1 | [
[
[
305,
24,
1236
]
],
[
[
305,
24,
362
],
[
362,
1,
1236
]
],
[
[
305,
24,
1632
],
[
1632,
62,
1236
]
],
[
[
305,
25,
1101
],
[
1101,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbamazepine"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Carbamazepine (Compound)
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Nicotinamide and Nicotinamide ... |
DB00757 | DB00808 | 1,166 | 1,605 | [
"DDInter581",
"DDInter916"
] | Dolasetron | Indapamide | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | The most significant modifiable risk factor for cardiovascular disease and the most prominent contributor to all-cause mortality is hypertension. Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts an estimated 25% of adults globally. Treatment for hypertension should include a n... | Major | 2 | [
[
[
1166,
25,
1605
]
],
[
[
1166,
64,
811
],
[
811,
1,
1605
]
],
[
[
1166,
6,
8374
],
[
8374,
45,
1605
]
],
[
[
1166,
21,
28826
],
[
28826... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Indapamide"
]
],
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Metolazone"
],
[
"Metolazone",
"{u} (... | Dolasetron may lead to a major life threatening interaction when taken with Metolazone and Metolazone (Compound) resembles Indapamide (Compound)
Dolasetron (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Indapamide (Compound)
Dolasetron (Compound) causes Jaundice (Side Effect) and Jaundice (Side Effect) is... |
DB00005 | DB00620 | 1,057 | 175 | [
"DDInter687",
"DDInter1855"
] | Etanercept | Triamcinolone | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Major | 2 | [
[
[
1057,
25,
175
]
],
[
[
1057,
25,
1573
],
[
1573,
1,
175
]
],
[
[
1057,
25,
617
],
[
617,
40,
175
]
],
[
[
1057,
24,
1072
],
[
1072,
... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Triamcinolone"
]
],
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prednisone"
],
[
"Prednisone",
"{u... | Etanercept may lead to a major life threatening interaction when taken with Prednisone and Prednisone (Compound) resembles Triamcinolone (Compound)
Etanercept may lead to a major life threatening interaction when taken with Budesonide and Budesonide (Compound) resembles Triamcinolone (Compound)
Etanercept may cause a m... |
DB00539 | DB08871 | 11 | 36 | [
"DDInter1837",
"DDInter666"
] | Toremifene | Eribulin | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Major | 2 | [
[
[
11,
25,
36
]
],
[
[
11,
5,
11579
],
[
11579,
44,
36
]
],
[
[
11,
18,
16974
],
[
16974,
45,
36
]
],
[
[
11,
24,
122
],
[
122,
23,... | [
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eribulin"
]
],
[
[
"Toremifene",
"{u} (Compound) treats {v} (Disease)",
"breast cancer"
],
[
"breast cancer",
"{u} (Disease) is treated by {v} (Compo... | Toremifene (Compound) treats breast cancer (Disease) and breast cancer (Disease) is treated by Eribulin (Compound)
Toremifene (Compound) downregulates TUBB6 (Gene) and TUBB6 (Gene) is bound by Eribulin (Compound)
Toremifene may cause a moderate interaction that could exacerbate diseases when taken with Verapamil and Ve... |
DB00564 | DB00603 | 1,236 | 303 | [
"DDInter293",
"DDInter1137"
] | Carbamazepine | Medroxyprogesterone acetate | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Moderate | 1 | [
[
[
1236,
24,
303
]
],
[
[
1236,
24,
167
],
[
167,
1,
303
]
],
[
[
1236,
6,
8374
],
[
8374,
45,
303
]
],
[
[
1236,
21,
28957
],
[
28957,
... | [
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Medroxyprogesterone acetate"
]
],
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydr... | Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Medroxyprogesterone acetate (Compound)
Carbamazepine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Medroxyprogesterone acetate (Compound)
Carbamazepine (Com... |
DB00427 | DB06702 | 1,233 | 573 | [
"DDInter1879",
"DDInter731"
] | Triprolidine | Fesoterodine | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Fesoterodine is an antimuscarinic prodrug for the treatment of overactive bladder syndrome. | Moderate | 1 | [
[
[
1233,
24,
573
]
],
[
[
1233,
24,
211
],
[
211,
1,
573
]
],
[
[
1233,
63,
494
],
[
494,
1,
573
]
],
[
[
1233,
6,
12523
],
[
12523,
... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fesoterodine"
]
],
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolterodine"
],
... | Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine and Tolterodine (Compound) resembles Fesoterodine (Compound)
Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Disopyramide and Disopyramide (Compound) resembles Fesoterodi... |
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