drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00903 | DB01246 | 1,680 | 820 | [
"DDInter686",
"DDInter45"
] | Etacrynic acid | Alimemazine | A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as ... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
1680,
24,
820
]
],
[
[
1680,
63,
104
],
[
104,
40,
820
]
],
[
[
1680,
24,
401
],
[
401,
24,
820
]
],
[
[
1680,
7,
3169
],
[
3169,
... | [
[
[
"Etacrynic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Etacrynic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
... | Etacrynic acid may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (Compound)
Etacrynic acid may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate inter... |
DB00230 | DB01105 | 784 | 222 | [
"DDInter1516",
"DDInter1665"
] | Pregabalin | Sibutramine | Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter. It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions. Although as per the FDA Label the mechanism of action has not been definitively characterized, there is evide... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
784,
24,
222
]
],
[
[
784,
21,
28737
],
[
28737,
60,
222
]
],
[
[
784,
24,
128
],
[
128,
24,
222
]
],
[
[
784,
24,
1311
],
[
1311,
... | [
[
[
"Pregabalin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Pregabalin",
"{u} (Compound) causes {v} (Side Effect)",
"Bursitis"
],
[
"Bursitis",
"{u} (Side Effect) is cause... | Pregabalin (Compound) causes Bursitis (Side Effect) and Bursitis (Side Effect) is caused by Sibutramine (Compound)
Pregabalin may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine and Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when tak... |
DB00900 | DB01017 | 45 | 1,669 | [
"DDInter544",
"DDInter1224"
] | Didanosine | Minocycline | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-termi... | Minocycline was first described in the literacture in 1966. It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria. Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetr... | Minor | 0 | [
[
[
45,
23,
1669
]
],
[
[
45,
62,
1572
],
[
1572,
1,
1669
]
],
[
[
45,
62,
1545
],
[
1545,
40,
1669
]
],
[
[
45,
6,
10612
],
[
10612,
... | [
[
[
"Didanosine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Minocycline"
]
],
[
[
"Didanosine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Demeclocycline"
],
[
... | Didanosine may cause a minor interaction that can limit clinical effects when taken with Demeclocycline and Demeclocycline (Compound) resembles Minocycline (Compound)
Didanosine may cause a minor interaction that can limit clinical effects when taken with Oxytetracycline and Oxytetracycline (Compound) resembles Minocyc... |
DB06589 | DB08868 | 1,250 | 1,011 | [
"DDInter1400",
"DDInter737"
] | Pazopanib | Fingolimod | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
1250,
25,
1011
]
],
[
[
1250,
6,
12523
],
[
12523,
45,
1011
]
],
[
[
1250,
21,
28792
],
[
28792,
60,
1011
]
],
[
[
1250,
62,
1247
],
[
... | [
[
[
"Pazopanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Pazopanib",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Fingolimo... | Pazopanib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Fingolimod (Compound)
Pazopanib (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Fingolimod (Compound)
Pazopanib may cause a minor interaction that can limit clinical effects when tak... |
DB00637 | DB08912 | 1,557 | 1,040 | [
"DDInter128",
"DDInter462"
] | Astemizole | Dabrafenib | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
1557,
24,
1040
]
],
[
[
1557,
6,
4973
],
[
4973,
45,
1040
]
],
[
[
1557,
7,
18110
],
[
18110,
46,
1040
]
],
[
[
1557,
18,
2183
],
[
21... | [
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Astemizole",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Astemizole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dabrafenib (Compound)
Astemizole (Compound) upregulates ST6GALNAC2 (Gene) and ST6GALNAC2 (Gene) is upregulated by Dabrafenib (Compound)
Astemizole (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Dabrafenib (Compound)
Astemi... |
DB06626 | DB08873 | 263 | 74 | [
"DDInter147",
"DDInter221"
] | Axitinib | Boceprevir | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | Boceprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in... | Major | 2 | [
[
[
263,
25,
74
]
],
[
[
263,
63,
86
],
[
86,
24,
74
]
],
[
[
263,
64,
1220
],
[
1220,
24,
74
]
],
[
[
263,
24,
1619
],
[
1619,
63,
... | [
[
[
"Axitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Boceprevir"
]
],
[
[
"Axitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miconazole"
],
[
"Miconazole",
... | Axitinib may cause a moderate interaction that could exacerbate diseases when taken with Miconazole and Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Boceprevir
Axitinib may lead to a major life threatening interaction when taken with Dexamethasone and Dexamethasone may caus... |
DB00960 | DB01142 | 887 | 1,264 | [
"DDInter1471",
"DDInter593"
] | Pindolol | Doxepin | Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the earl... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
887,
24,
1264
]
],
[
[
887,
24,
401
],
[
401,
24,
1264
]
],
[
[
887,
6,
8742
],
[
8742,
45,
1264
]
],
[
[
887,
18,
19557
],
[
19557,
... | [
[
[
"Pindolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Pindolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
"... | Pindolol may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Pindolol (Compound) binds HTR1A (Gene) and HTR1A (Gene) is bound by Doxepin (Compound)
Pindolol (Compound) downre... |
DB00970 | DB10316 | 0 | 334 | [
"DDInter466",
"DDInter1248"
] | Dactinomycin | Mumps virus strain B level jeryl lynn live antigen | A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also d... | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
0,
25,
334
]
],
[
[
0,
64,
1057
],
[
1057,
25,
334
]
],
[
[
0,
24,
328
],
[
328,
25,
334
]
],
[
[
0,
25,
908
],
[
908,
25,
... | [
[
[
"Dactinomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Dactinomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
... | Dactinomycin may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Mumps virus strain B level jeryl lynn live antigen
Dactinomycin may cause a moderate interaction that could exacerbate diseases when taken with Mercapt... |
DB00879 | DB09065 | 1,279 | 760 | [
"DDInter637",
"DDInter424"
] | Emtricitabine | Cobicistat | Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) indicated for the treatment of HIV infection in adults or combined with [tenofovir alafenamide] for the prevention of HIV-1 infection in high risk adolescents and adults. Emtricitabine is a cytidine analogue. The drug works by inhibiting HIV reverse t... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
1279,
24,
760
]
],
[
[
1279,
24,
384
],
[
384,
24,
760
]
],
[
[
1279,
24,
1618
],
[
1618,
25,
760
]
],
[
[
1279,
24,
384
],
[
384,
... | [
[
[
"Emtricitabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Emtricitabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
... | Emtricitabine may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat
Emtricitabine may cause a moderate interaction that could exacerbate diseases when taken with Cabozantinib an... |
DB05294 | DB06616 | 1,069 | 594 | [
"DDInter1917",
"DDInter224"
] | Vandetanib | Bosutinib | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Major | 2 | [
[
[
1069,
36,
594
]
],
[
[
1069,
1,
883
],
[
883,
1,
594
]
],
[
[
1069,
6,
8152
],
[
8152,
45,
594
]
],
[
[
1069,
54,
19212
],
[
19212,
... | [
[
[
"Vandetanib",
"{u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v}",
"Bosutinib"
]
],
[
[
"Vandetanib",
"{u} (Compound) resembles {v} (Compound)",
"Gefitinib"
],
[
"Gefitinib",
... | Vandetanib (Compound) resembles Bosutinib (Compound) and
Vandetanib (Compound) resembles Gefitinib (Compound) and Gefitinib (Compound) resembles Bosutinib (Compound)
Vandetanib (Compound) binds MAP4K5 (Gene) and MAP4K5 (Gene) is bound by Bosutinib (Compound)
Vandetanib (Compound) is included by Protein Kinase Inhibitor... |
DB00675 | DB08903 | 888 | 996 | [
"DDInter1744",
"DDInter170"
] | Tamoxifen | Bedaquiline | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affe... | Major | 2 | [
[
[
888,
36,
996
]
],
[
[
888,
1,
11296
],
[
11296,
1,
996
]
],
[
[
888,
40,
649
],
[
649,
1,
996
]
],
[
[
888,
25,
1376
],
[
1376,
... | [
[
[
"Tamoxifen",
"{u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v}",
"Bedaquiline"
]
],
[
[
"Tamoxifen",
"{u} (Compound) resembles {v} (Compound)",
"Bromodiphenhydramine"
],
[
"Bromo... | Tamoxifen (Compound) resembles Bedaquiline (Compound) and
Tamoxifen (Compound) resembles Bromodiphenhydramine (Compound) and Bromodiphenhydramine (Compound) resembles Bedaquiline (Compound)
Tamoxifen (Compound) resembles Clofedanol (Compound) and Clofedanol (Compound) resembles Bedaquiline (Compound)
Tamoxifen may lead... |
DB00231 | DB00283 | 1,174 | 701 | [
"DDInter1761",
"DDInter395"
] | Temazepam | Clemastine | Temazepam, like many other similar and related benzodiazepines, acts as a gamma-aminobutyric acid (GABA) modulator and is capable of eliciting a variety of actions including sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action [A175207, A175210, F3718, F3721]. Although the chem... | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Moderate | 1 | [
[
[
1174,
24,
701
]
],
[
[
1174,
24,
649
],
[
649,
63,
701
]
],
[
[
1174,
6,
8374
],
[
8374,
45,
701
]
],
[
[
1174,
21,
28929
],
[
28929,
... | [
[
[
"Temazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
]
],
[
[
"Temazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],
[
... | Temazepam may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Clemastine
Temazepam (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Clemastine (Compound)
Temazepam (Compound)... |
DB00970 | DB11817 | 0 | 1,259 | [
"DDInter466",
"DDInter165"
] | Dactinomycin | Baricitinib | A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also d... | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Major | 2 | [
[
[
0,
25,
1259
]
],
[
[
0,
63,
1461
],
[
1461,
23,
1259
]
],
[
[
0,
24,
949
],
[
949,
24,
1259
]
],
[
[
0,
24,
1129
],
[
1129,
63,
... | [
[
[
"Dactinomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Baricitinib"
]
],
[
[
"Dactinomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitami... | Dactinomycin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Baricitinib
Dactinomycin may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani t... |
DB14723 | DB15233 | 159 | 1,650 | [
"DDInter1026",
"DDInter142"
] | Larotrectinib | Avapritinib | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis.[A189339,L40363] It is one of the first medications available for the trea... | Moderate | 1 | [
[
[
159,
24,
1650
]
],
[
[
159,
63,
1478
],
[
1478,
24,
1650
]
],
[
[
159,
62,
222
],
[
222,
24,
1650
]
],
[
[
159,
63,
1409
],
[
1409,
... | [
[
[
"Larotrectinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Avapritinib"
]
],
[
[
"Larotrectinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
],
... | Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Avapritinib
Larotrectinib may cause a minor interaction that can limit clinical effects when taken with Sibutramine and Si... |
DB00533 | DB11921 | 1,416 | 1,019 | [
"DDInter1613",
"DDInter492"
] | Rofecoxib | Deflazacort | Rofecoxib is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras. Rofecoxib is a solid. This compound belongs to the stilbenes. These are organic compounds containing a 1,2-diphenylethylene m... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
1416,
24,
1019
]
],
[
[
1416,
24,
959
],
[
959,
24,
1019
]
],
[
[
1416,
25,
629
],
[
629,
24,
1019
]
],
[
[
1416,
24,
877
],
[
877,
... | [
[
[
"Rofecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Rofecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Rofecoxib may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Rofecoxib may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus may cause a mod... |
DB00834 | DB11110 | 932 | 603 | [
"DDInter1215",
"DDInter1115"
] | Mifepristone | Magnesium citrate | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
932,
24,
603
]
],
[
[
932,
25,
57
],
[
57,
24,
603
]
],
[
[
932,
64,
870
],
[
870,
24,
603
]
],
[
[
932,
25,
484
],
[
484,
63,
... | [
[
[
"Mifepristone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Mifepristone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
[
... | Mifepristone may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Mifepristone may lead to a major life threatening interaction when taken with Fludrocortisone and Fludroco... |
DB00749 | DB01082 | 59 | 1,448 | [
"DDInter699",
"DDInter1713"
] | Etodolac | Streptomycin | Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | Moderate | 1 | [
[
[
59,
24,
1448
]
],
[
[
59,
6,
10612
],
[
10612,
45,
1448
]
],
[
[
59,
21,
29327
],
[
29327,
60,
1448
]
],
[
[
59,
24,
1272
],
[
1272,
... | [
[
[
"Etodolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Streptomycin"
]
],
[
[
"Etodolac",
"{u} (Compound) binds {v} (Gene)",
"SLC22A6"
],
[
"SLC22A6",
"{u} (Gene) is bound by {v} (Compound)",... | Etodolac (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Streptomycin (Compound)
Etodolac (Compound) causes Renal failure (Side Effect) and Renal failure (Side Effect) is caused by Streptomycin (Compound)
Etodolac may cause a moderate interaction that could exacerbate diseases when taken with Flucytosine... |
DB09381 | DB11901 | 192 | 913 | [
"DDInter678",
"DDInter107"
] | Esterified estrogens | Apalutamide | Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of me... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
192,
24,
913
]
],
[
[
192,
63,
600
],
[
600,
24,
913
]
],
[
[
192,
24,
1320
],
[
1320,
63,
913
]
],
[
[
192,
64,
1668
],
[
1668,
... | [
[
[
"Esterified estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Esterified estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flucon... | Esterified estrogens may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Esterified estrogens may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB01142 | DB09488 | 1,264 | 103 | [
"DDInter593",
"DDInter23"
] | Doxepin | Acrivastine | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Acrivastine is a triprolidine analog antihistamine indicated for the treatment of allergies and hay fever. As an H1 receptor antagonist, it functions by blocking the action of histamine at this receptor thereby preventing the symptoms associated with histamine release such as pruritis, vasodilation, hypotension, edema,... | Moderate | 1 | [
[
[
1264,
24,
103
]
],
[
[
1264,
64,
1405
],
[
1405,
24,
103
]
],
[
[
1264,
63,
413
],
[
413,
24,
103
]
],
[
[
1264,
24,
573
],
[
573,
... | [
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acrivastine"
]
],
[
[
"Doxepin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cyclobenzaprine"
],
[
"Cyclobenza... | Doxepin may lead to a major life threatening interaction when taken with Cyclobenzaprine and Cyclobenzaprine may cause a moderate interaction that could exacerbate diseases when taken with Acrivastine
Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline and Maprotiline may... |
DB00916 | DB11901 | 112 | 913 | [
"DDInter1202",
"DDInter107"
] | Metronidazole | Apalutamide | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Minor | 0 | [
[
[
112,
23,
913
]
],
[
[
112,
24,
110
],
[
110,
62,
913
]
],
[
[
112,
23,
1247
],
[
1247,
23,
913
]
],
[
[
112,
25,
279
],
[
279,
2... | [
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Apalutamide"
]
],
[
[
"Metronidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polatuzumab vedotin"
... | Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Polatuzumab vedotin and Polatuzumab vedotin may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Metronidazole may cause a minor interaction that can limit clinical effects when taken with ... |
DB00514 | DB00906 | 506 | 1,567 | [
"DDInter527",
"DDInter1801"
] | Dextromethorphan | Tiagabine | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Tiagabine is an anti-convulsive medication. It is also used in the treatment for panic disorder as are a few other anticonvulsants. Though the exact mechanism by which tiagabine exerts its effect on the human body is unknown, it does appear to operate as a selective GABA reuptake inhibitor. | Moderate | 1 | [
[
[
506,
24,
1567
]
],
[
[
506,
6,
8374
],
[
8374,
45,
1567
]
],
[
[
506,
21,
28658
],
[
28658,
60,
1567
]
],
[
[
506,
63,
530
],
[
530,
... | [
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tiagabine"
]
],
[
[
"Dextromethorphan",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (... | Dextromethorphan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Tiagabine (Compound)
Dextromethorphan (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Tiagabine (Compound)
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Drona... |
DB00889 | DB01246 | 1,133 | 820 | [
"DDInter840",
"DDInter45"
] | Granisetron | Alimemazine | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
1133,
24,
820
]
],
[
[
1133,
63,
1335
],
[
1335,
24,
820
]
],
[
[
1133,
24,
401
],
[
401,
24,
820
]
],
[
[
1133,
63,
675
],
[
675,
... | [
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxcarbazepine"
],
... | Granisetron may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine and Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Granisetron may cause a moderate interaction that could exacerbate diseases when taken with Promethazine... |
DB00407 | DB01166 | 202 | 477 | [
"DDInter115",
"DDInter379"
] | Ardeparin | Cilostazol | Ardeparin, marketed under the US trade name Normiflo, is a low molecular weight heparin (LMWH) anticoagulant used for the prevention of postoperative venous thrombosis. Ardeparin is derived via peroxide degradation of heparin extracted from porcine intestinal mucosa. Its molecular weight ranges from 2000 to 15,000 with... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Major | 2 | [
[
[
202,
25,
477
]
],
[
[
202,
21,
28642
],
[
28642,
60,
477
]
],
[
[
202,
25,
126
],
[
126,
23,
477
]
],
[
[
202,
25,
936
],
[
936,
... | [
[
[
"Ardeparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cilostazol"
]
],
[
[
"Ardeparin",
"{u} (Compound) causes {v} (Side Effect)",
"Shock"
],
[
"Shock",
"{u} (Side Effect) is caused by {v} (Compound)",
... | Ardeparin (Compound) causes Shock (Side Effect) and Shock (Side Effect) is caused by Cilostazol (Compound)
Ardeparin may lead to a major life threatening interaction when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken with Cilostazol
Ardeparin may lead to a maj... |
DB00191 | DB01364 | 73 | 22 | [
"DDInter1447",
"DDInter650"
] | Phentermine | Ephedrine | Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine. Phentermine has not been reported an addictive potential which allows thi... | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Moderate | 1 | [
[
[
73,
35,
22
]
],
[
[
73,
1,
80
],
[
80,
24,
22
]
],
[
[
73,
1,
11353
],
[
11353,
40,
22
]
],
[
[
73,
1,
11216
],
[
11216,
1,
... | [
[
[
"Phentermine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ephedrine"
]
],
[
[
"Phentermine",
"{u} (Compound) resembles {v} (Compound)",
"Amphetamine"
],
[
... | Phentermine (Compound) resembles Ephedrine (Compound) and
Phentermine (Compound) resembles Amphetamine (Compound) and Amphetamine may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine
Phentermine (Compound) resembles Benzyl alcohol (Compound) and Benzyl alcohol (Compound) resembles E... |
DB01019 | DB09076 | 427 | 1,116 | [
"DDInter199",
"DDInter1899"
] | Bethanechol | Umeclidinium | Bethanechol is a synthetic ester that was initially synthesized in 1935.[A232905,L32539] As a cholinergic agent, bethanechol is similar in structure and pharmacological function to acetylcholine and is used in specific cases when stimulation of the parasympathetic nervous system is necessary.[A232905,L32539] For exampl... | Umeclidinium is a long-acting muscarinic antagonist (LAMA) used as a maintenance treatment for symptoms of chronic obstructive pulmonary disease (COPD). COPD is a progressive obstructive lung disease characterized by shortness of breath, cough, sputum production, and chronically poor airflow with a forced expiratory vo... | Moderate | 1 | [
[
[
427,
24,
1116
]
],
[
[
427,
24,
1511
],
[
1511,
24,
1116
]
],
[
[
427,
63,
1442
],
[
1442,
24,
1116
]
],
[
[
427,
24,
1511
],
[
1511,
... | [
[
[
"Bethanechol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Umeclidinium"
]
],
[
[
"Bethanechol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
... | Bethanechol may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Umeclidinium
Bethanechol may cause a moderate interaction that could exacerbate diseases when taken with Scopolamine and... |
DB00704 | DB09122 | 267 | 1,613 | [
"DDInter1263",
"DDInter1409"
] | Naltrexone | Peginterferon beta-1a | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
267,
24,
1613
]
],
[
[
267,
24,
671
],
[
671,
24,
1613
]
],
[
[
267,
63,
152
],
[
152,
24,
1613
]
],
[
[
267,
24,
975
],
[
975,
... | [
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
... | Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Bosentan... |
DB00595 | DB13142 | 1,545 | 841 | [
"DDInter1374",
"DDInter274"
] | Oxytetracycline | Calcium glubionate anhydrous | A tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety of clinical conditions. | Calcium glubionate (or glubionate calcium) is a mineral supplement to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets. | Moderate | 1 | [
[
[
1545,
24,
841
]
],
[
[
1545,
40,
1669
],
[
1669,
24,
841
]
],
[
[
1545,
23,
504
],
[
504,
24,
841
]
],
[
[
1545,
63,
1252
],
[
1252,
... | [
[
[
"Oxytetracycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium glubionate anhydrous"
]
],
[
[
"Oxytetracycline",
"{u} (Compound) resembles {v} (Compound)",
"Minocycline"
],
[
"Minocycline",
... | Oxytetracycline (Compound) resembles Minocycline (Compound) and Minocycline may cause a moderate interaction that could exacerbate diseases when taken with Calcium glubionate anhydrous
Oxytetracycline may cause a minor interaction that can limit clinical effects when taken with Hydrochlorothiazide and Hydrochlorothiazi... |
DB05294 | DB06288 | 1,069 | 607 | [
"DDInter1917",
"DDInter77"
] | Vandetanib | Amisulpride | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Amisulpride is a benzamide derivative and a dopamine receptor antagonist that selectively works on dopamine D2 and D3 receptors. As an antipsychotic agent, amisulpride alleviates both positive and negative symptoms of schizophrenia, and it exhibits antidepressant properties in patients with psychiatric disorders, dysth... | Major | 2 | [
[
[
1069,
25,
607
]
],
[
[
1069,
21,
28785
],
[
28785,
60,
607
]
],
[
[
1069,
62,
112
],
[
112,
23,
607
]
],
[
[
1069,
63,
1559
],
[
1559,... | [
[
[
"Vandetanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amisulpride"
]
],
[
[
"Vandetanib",
"{u} (Compound) causes {v} (Side Effect)",
"Muscle spasms"
],
[
"Muscle spasms",
"{u} (Side Effect) is caused by ... | Vandetanib (Compound) causes Muscle spasms (Side Effect) and Muscle spasms (Side Effect) is caused by Amisulpride (Compound)
Vandetanib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken w... |
DB00104 | DB00489 | 966 | 17 | [
"DDInter1323",
"DDInter1704"
] | Octreotide | Sotalol | Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may... | Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventric... | Moderate | 1 | [
[
[
966,
24,
17
]
],
[
[
966,
24,
88
],
[
88,
40,
17
]
],
[
[
966,
21,
28719
],
[
28719,
60,
17
]
],
[
[
966,
24,
1296
],
[
1296,
63... | [
[
[
"Octreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sotalol"
]
],
[
[
"Octreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoprolol"
],
[
... | Octreotide may cause a moderate interaction that could exacerbate diseases when taken with Metoprolol and Metoprolol (Compound) resembles Sotalol (Compound)
Octreotide (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Sotalol (Compound)
Octreotide may cause a moderate interaction that could exace... |
DB00019 | DB00069 | 1,257 | 367 | [
"DDInter1405",
"DDInter946"
] | Pegfilgrastim | Interferon alfacon-1 | Pegfilgrastim is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (G-CSF) analogue, [filgrastim]. The drug is approved for use to decrease the incidence of infection, as manifested by febrile neutropenia, in susceptible patients with with non-myeloid cancer receiving myelosuppressive anti... | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Moderate | 1 | [
[
[
1257,
24,
367
]
],
[
[
1257,
24,
450
],
[
450,
62,
367
]
],
[
[
1257,
24,
599
],
[
599,
63,
367
]
],
[
[
1257,
24,
305
],
[
305,
... | [
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Interferon alfacon-1"
]
],
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclophosph... | Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Cyclophosphamide and Cyclophosphamide may cause a minor interaction that can limit clinical effects when taken with Interferon alfacon-1
Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken ... |
DB01173 | DB01619 | 358 | 830 | [
"DDInter1349",
"DDInter1441"
] | Orphenadrine | Phenindamine | A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm. | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Moderate | 1 | [
[
[
358,
24,
830
]
],
[
[
358,
40,
11286
],
[
11286,
1,
830
]
],
[
[
358,
24,
537
],
[
537,
40,
830
]
],
[
[
358,
63,
1219
],
[
1219,
... | [
[
[
"Orphenadrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
]
],
[
[
"Orphenadrine",
"{u} (Compound) resembles {v} (Compound)",
"Diphenylpyraline"
],
[
"Diphenylpyraline",
"{u} (... | Orphenadrine (Compound) resembles Diphenylpyraline (Compound) and Diphenylpyraline (Compound) resembles Phenindamine (Compound)
Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) resembles Phenindamine (Compound)
Orphenadrine may cause a moder... |
DB00388 | DB04896 | 1,636 | 901 | [
"DDInter1453",
"DDInter1220"
] | Phenylephrine | Milnacipran | Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939. | Milnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment of depression [F3928, F3934, A175786, A175951]. Furthermore, in 2009 the US FDA approved milnacipran for the a... | Moderate | 1 | [
[
[
1636,
24,
901
]
],
[
[
1636,
24,
41
],
[
41,
1,
901
]
],
[
[
1636,
21,
28722
],
[
28722,
60,
901
]
],
[
[
1636,
24,
1148
],
[
1148,
... | [
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milnacipran"
]
],
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
... | Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran and Levomilnacipran (Compound) resembles Milnacipran (Compound)
Phenylephrine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Milnacipran (Compound)
Phenylephrine may cause a modera... |
DB00519 | DB00620 | 1,638 | 175 | [
"DDInter1843",
"DDInter1855"
] | Trandolapril | Triamcinolone | Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiote... | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Moderate | 1 | [
[
[
1638,
24,
175
]
],
[
[
1638,
24,
1573
],
[
1573,
1,
175
]
],
[
[
1638,
24,
617
],
[
617,
40,
175
]
],
[
[
1638,
63,
251
],
[
251,
... | [
[
[
"Trandolapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
]
],
[
[
"Trandolapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
],
... | Trandolapril may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone (Compound) resembles Triamcinolone (Compound)
Trandolapril may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and Budesonide (Compound) resembles Triamcinolone (... |
DB00085 | DB14491 | 639 | 428 | [
"DDInter1384",
"DDInter725"
] | Pancrelipase | Ferrous fumarate | Pancrelipase, in general, is composed of a mixture of pancreatic enzymes which include amylases, lipases, and proteases. These enzymes are extracted from porcine pancreatic glands. The pancrelipase mixture was developed by Ortho-McNeil-Janssen Pharmaceuticals, Inc and FDA approved on April 12, 2010. For further informa... | Used in treatment of iron deficiency anemia. | Moderate | 1 | [
[
[
639,
24,
428
]
],
[
[
639,
24,
1384
],
[
1384,
24,
428
]
],
[
[
639,
24,
1384
],
[
1384,
63,
1096
],
[
1096,
23,
428
]
],
[
[
639,
... | [
[
[
"Pancrelipase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous fumarate"
]
],
[
[
"Pancrelipase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magaldrate"
]... | Pancrelipase may cause a moderate interaction that could exacerbate diseases when taken with Magaldrate and Magaldrate may cause a moderate interaction that could exacerbate diseases when taken with Ferrous fumarate
Pancrelipase may cause a moderate interaction that could exacerbate diseases when taken with Magaldrate ... |
DB00414 | DB01044 | 590 | 246 | [
"DDInter16",
"DDInter809"
] | Acetohexamide | Gatifloxacin | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Major | 2 | [
[
[
590,
25,
246
]
],
[
[
590,
64,
1176
],
[
1176,
1,
246
]
],
[
[
590,
25,
872
],
[
872,
40,
246
]
],
[
[
590,
24,
1532
],
[
1532,
... | [
[
[
"Acetohexamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gatifloxacin"
]
],
[
[
"Acetohexamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Moxifloxacin"
],
[
"Moxifloxacin",
... | Acetohexamide may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Gatifloxacin (Compound)
Acetohexamide may lead to a major life threatening interaction when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Gatifloxacin (Compound)
Acetohexamid... |
DB00197 | DB01076 | 1,324 | 700 | [
"DDInter1881",
"DDInter133"
] | Troglitazone | Atorvastatin | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Moderate | 1 | [
[
[
1324,
24,
700
]
],
[
[
1324,
24,
1080
],
[
1080,
1,
700
]
],
[
[
1324,
24,
303
],
[
303,
23,
700
]
],
[
[
1324,
24,
578
],
[
578,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atorvastatin"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Conivaptan"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Conivaptan and Conivaptan (Compound) resembles Atorvastatin (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Medroxyprogesterone acetate and Medroxyprogesterone acetate may... |
DB01229 | DB11652 | 973 | 1,155 | [
"DDInter1377",
"DDInter1891"
] | Paclitaxel | Tucatinib | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Tucatinib is a kinase inhibitor drug used with [trastuzumab] and [capecitabine] in the treatment of unresectable or metastatic HER-2 positive breast cancer. It was developed by Seattle Genetics and approved by the FDA on April 17, 2020. Tucatinib is a promising new treatment for patients with metastatic breast cancer w... | Moderate | 1 | [
[
[
973,
24,
1155
]
],
[
[
973,
63,
1101
],
[
1101,
23,
1155
]
],
[
[
973,
63,
1424
],
[
1424,
24,
1155
]
],
[
[
973,
24,
309
],
[
309,
... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tucatinib"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Tucatinib
Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinine may ... |
DB00694 | DB11003 | 51 | 748 | [
"DDInter485",
"DDInter100"
] | Daunorubicin | Anthrax vaccine | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsula... | Moderate | 1 | [
[
[
51,
24,
748
]
],
[
[
51,
74,
322
],
[
322,
24,
748
]
],
[
[
51,
24,
896
],
[
896,
24,
748
]
],
[
[
51,
25,
676
],
[
676,
63,
... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
]
],
[
[
"Daunorubicin",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases whe... | Daunorubicin (Compound) resembles Epirubicin (Compound) and Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine
Daunorubicin may cause a moderate interaction... |
DB00601 | DB08870 | 453 | 850 | [
"DDInter1073",
"DDInter228"
] | Linezolid | Brentuximab vedotin | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
453,
24,
850
]
],
[
[
453,
24,
896
],
[
896,
24,
850
]
],
[
[
453,
63,
134
],
[
134,
24,
850
]
],
[
[
453,
24,
1468
],
[
1468,
6... | [
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
],
... | Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and ... |
DB01149 | DB06704 | 851 | 247 | [
"DDInter1274",
"DDInter951"
] | Nefazodone | Iobenguane (I-123) | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Moderate | 1 | [
[
[
851,
24,
247
]
],
[
[
851,
6,
7390
],
[
7390,
45,
247
]
],
[
[
851,
18,
7359
],
[
7359,
57,
247
]
],
[
[
851,
21,
28787
],
[
28787,
... | [
[
[
"Nefazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iobenguane"
]
],
[
[
"Nefazodone",
"{u} (Compound) binds {v} (Gene)",
"SLC6A2"
],
[
"SLC6A2",
"{u} (Gene) is bound by {v} (Compound)",... | Nefazodone may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane
Nefazodone (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Iobenguane (Compound)
Nefazodone (Compound) downregulates TXNDC9 (Gene) and TXNDC9 (Gene) is downregulated by Iobenguane (Compound)
Nefazodone (Co... |
DB00580 | DB00795 | 311 | 50 | [
"DDInter1910",
"DDInter1725"
] | Valdecoxib | Sulfasalazine | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down i... | Moderate | 1 | [
[
[
311,
24,
50
]
],
[
[
311,
24,
712
],
[
712,
1,
50
]
],
[
[
311,
63,
305
],
[
305,
24,
50
]
],
[
[
311,
24,
1144
],
[
1144,
24,
... | [
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfasalazine"
]
],
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olsalazine"
],
[... | Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Olsalazine and Olsalazine (Compound) resembles Sulfasalazine (Compound)
Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia coli and Asparaginase Escherichia coli ma... |
DB00850 | DB11730 | 1,630 | 351 | [
"DDInter1432",
"DDInter1588"
] | Perphenazine | Ribociclib | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
1630,
25,
351
]
],
[
[
1630,
23,
112
],
[
112,
23,
351
]
],
[
[
1630,
24,
222
],
[
222,
23,
351
]
],
[
[
1630,
24,
283
],
[
283,
... | [
[
[
"Perphenazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Perphenazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metro... | Perphenazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and... |
DB00726 | DB09291 | 1,164 | 741 | [
"DDInter1876",
"DDInter1615"
] | Trimipramine | Rolapitant | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Rolapitant is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and vomiting (CINV) in adults. Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated by Neurokinin-1 and its l... | Moderate | 1 | [
[
[
1164,
24,
741
]
],
[
[
1164,
35,
1264
],
[
1264,
24,
741
]
],
[
[
1164,
24,
1342
],
[
1342,
24,
741
]
],
[
[
1164,
25,
478
],
[
478,
... | [
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
]
],
[
[
"Trimipramine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when tak... | Trimipramine (Compound) resembles Doxepin (Compound) and Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant
Trimipramine may cause a moderate interaction that could ex... |
DB00531 | DB15091 | 450 | 676 | [
"DDInter456",
"DDInter1901"
] | Cyclophosphamide | Upadacitinib | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
450,
25,
676
]
],
[
[
450,
63,
1461
],
[
1461,
23,
676
]
],
[
[
450,
24,
1430
],
[
1430,
24,
676
]
],
[
[
450,
63,
188
],
[
188,
... | [
[
[
"Cyclophosphamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Upadacitinib
Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-... |
DB00661 | DB06335 | 122 | 761 | [
"DDInter1928",
"DDInter1646"
] | Verapamil | Saxagliptin | Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
122,
24,
761
]
],
[
[
122,
6,
10417
],
[
10417,
45,
761
]
],
[
[
122,
21,
28966
],
[
28966,
60,
761
]
],
[
[
122,
24,
1491
],
[
1491,
... | [
[
[
"Verapamil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Verapamil",
"{u} (Compound) binds {v} (Gene)",
"ABCC1"
],
[
"ABCC1",
"{u} (Gene) is bound by {v} (Compound)",
... | Verapamil (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Saxagliptin (Compound)
Verapamil (Compound) causes Upper respiratory tract infection (Side Effect) and Upper respiratory tract infection (Side Effect) is caused by Saxagliptin (Compound)
Verapamil may cause a moderate interaction that could exacerbate... |
DB00454 | DB01575 | 1,349 | 1,054 | [
"DDInter1150",
"DDInter1005"
] | Meperidine | Kaolin | A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration. | Kaolin is a layered silicate mineral. Kaolin is used in ceramics, medicine, coated paper, as a food additive, in toothpaste, as a light diffusing material in white incandescent light bulbs, and in cosmetics. Until the early 1990s it was the active substance of anti-diarrhoea medicine Kaopectate. | Moderate | 1 | [
[
[
1349,
24,
1054
]
],
[
[
1349,
24,
407
],
[
407,
63,
1054
]
],
[
[
1349,
24,
85
],
[
85,
24,
1054
]
],
[
[
1349,
64,
475
],
[
475,
... | [
[
[
"Meperidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Kaolin"
]
],
[
[
"Meperidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
],
[
"Opiu... | Meperidine may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause a moderate interaction that could exacerbate diseases when taken with Kaolin
Meperidine may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine may cause a m... |
DB11718 | DB12825 | 927 | 1,375 | [
"DDInter640",
"DDInter1032"
] | Encorafenib | Lefamulin | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Major | 2 | [
[
[
927,
25,
1375
]
],
[
[
927,
62,
112
],
[
112,
23,
1375
]
],
[
[
927,
24,
159
],
[
159,
63,
1375
]
],
[
[
927,
63,
309
],
[
309,
... | [
[
[
"Encorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lefamulin"
]
],
[
[
"Encorafenib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronid... | Encorafenib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lefamulin
Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and ... |
DB00673 | DB01611 | 723 | 1,487 | [
"DDInter112",
"DDInter893"
] | Aprepitant | Hydroxychloroquine | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Moderate | 1 | [
[
[
723,
24,
1487
]
],
[
[
723,
21,
28658
],
[
28658,
60,
1487
]
],
[
[
723,
24,
211
],
[
211,
23,
1487
]
],
[
[
723,
63,
168
],
[
168,
... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Aprepitant",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Effect) i... | Aprepitant (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Hydroxychloroquine (Compound)
Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine and Tolterodine may cause a minor interaction that can limit clinical effects when taken with H... |
DB01165 | DB11986 | 1,539 | 484 | [
"DDInter1325",
"DDInter648"
] | Ofloxacin | Entrectinib | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
1539,
24,
484
]
],
[
[
1539,
62,
112
],
[
112,
23,
484
]
],
[
[
1539,
24,
774
],
[
774,
24,
484
]
],
[
[
1539,
63,
1674
],
[
1674,
... | [
[
[
"Ofloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Ofloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Ofloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Ofloxacin may cause a moderate interaction that could exacerbate diseases when taken with Degarelix and Degare... |
DB01234 | DB01265 | 1,220 | 1,477 | [
"DDInter513",
"DDInter1757"
] | Dexamethasone | Telbivudine | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Telbivudine is a synthetic thymidine nucleoside analog with specific activity against the hepatitis B virus. Telbivudine is orally administered, with good tolerance, lack of toxicity and no dose-limiting side effects. | Moderate | 1 | [
[
[
1220,
24,
1477
]
],
[
[
1220,
63,
139
],
[
139,
1,
1477
]
],
[
[
1220,
21,
28745
],
[
28745,
60,
1477
]
],
[
[
1220,
1,
175
],
[
175,
... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telbivudine"
]
],
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zidovudine"
],
... | Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine and Zidovudine (Compound) resembles Telbivudine (Compound)
Dexamethasone (Compound) causes Neuropathy peripheral (Side Effect) and Neuropathy peripheral (Side Effect) is caused by Telbivudine (Compound)
Dexamethason... |
DB00717 | DB11986 | 1,197 | 484 | [
"DDInter1312",
"DDInter648"
] | Norethisterone | Entrectinib | Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins. It is further classified as a second-generation progestin, along with [levonorgestrel] and its derivatives, and is the active form of several other progestins including [no... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
1197,
24,
484
]
],
[
[
1197,
24,
1320
],
[
1320,
24,
484
]
],
[
[
1197,
25,
927
],
[
927,
24,
484
]
],
[
[
1197,
24,
159
],
[
159,
... | [
[
[
"Norethisterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Norethisterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
],
... | Norethisterone may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elagolix may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib
Norethisterone may lead to a major life threatening interaction when taken with Encorafenib and Encorafenib may... |
DB00108 | DB04868 | 1,066 | 478 | [
"DDInter1268",
"DDInter1293"
] | Natalizumab | Nilotinib | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Major | 2 | [
[
[
1066,
25,
478
]
],
[
[
1066,
25,
1468
],
[
1468,
63,
478
]
],
[
[
1066,
25,
1486
],
[
1486,
24,
478
]
],
[
[
1066,
64,
912
],
[
912,
... | [
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
]
],
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ponatinib"
],
[
"Ponatinib",
"{u} ma... | Natalizumab may lead to a major life threatening interaction when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib
Natalizumab may lead to a major life threatening interaction when taken with Methylprednisolone and Methylprednisolone may cause ... |
DB01284 | DB05679 | 1,042 | 1,683 | [
"DDInter1782",
"DDInter1907"
] | Tetracosactide | Ustekinumab | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Moderate | 1 | [
[
[
1042,
24,
1683
]
],
[
[
1042,
24,
1129
],
[
1129,
63,
1683
]
],
[
[
1042,
63,
409
],
[
409,
24,
1683
]
],
[
[
1042,
24,
4
],
[
4,
... | [
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]
],
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e... | Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen and Human adenovirus e serotype 4 strain cl-68578 antigen may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab
Tetracosactide may ca... |
DB00863 | DB01336 | 1,194 | 545 | [
"DDInter1568",
"DDInter1198"
] | Ranitidine | Metocurine | Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as [cimetidine] and [famotidine]. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.[A176759,L10818]... | Dimethyltubocurarinium (INN) or metocurine (USAN), also known as dimethyltubocurarine, is a non-depolarizing muscle relaxant. Patients on chronic anticonvulsant drugs are relatively resistant to metocurine. | Minor | 0 | [
[
[
1194,
23,
545
]
],
[
[
1194,
23,
1217
],
[
1217,
40,
545
]
],
[
[
1194,
63,
1031
],
[
1031,
24,
545
]
],
[
[
1194,
23,
1217
],
[
1217,... | [
[
[
"Ranitidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metocurine"
]
],
[
[
"Ranitidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Tubocurarine"
],
[
... | Ranitidine may cause a minor interaction that can limit clinical effects when taken with Tubocurarine and Tubocurarine (Compound) resembles Metocurine (Compound)
Ranitidine may cause a moderate interaction that could exacerbate diseases when taken with Theophylline and Theophylline may cause a moderate interaction that... |
DB00512 | DB00563 | 91 | 663 | [
"DDInter1916",
"DDInter1174"
] | Vancomycin | Methotrexate | Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear. As of January 29 2018, CutisPharma's Firvanq is the only FDA approved vancomycin oral liquid treatment option available for the the treatm... | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Moderate | 1 | [
[
[
91,
24,
663
]
],
[
[
91,
6,
10612
],
[
10612,
45,
663
]
],
[
[
91,
21,
28681
],
[
28681,
60,
663
]
],
[
[
91,
24,
1287
],
[
1287,
... | [
[
[
"Vancomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
]
],
[
[
"Vancomycin",
"{u} (Compound) binds {v} (Gene)",
"SLC22A6"
],
[
"SLC22A6",
"{u} (Gene) is bound by {v} (Compoun... | Vancomycin (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Methotrexate (Compound)
Vancomycin (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Methotrexate (Compound)
Vancomycin may cause a moderate interaction that could exacerbate diseases when taken with... |
DB01254 | DB06643 | 1,213 | 1,136 | [
"DDInter484",
"DDInter500"
] | Dasatinib | Denosumab | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL inhibitor approved to prevent osteoclast-mediated bone loss.... | Moderate | 1 | [
[
[
1213,
24,
1136
]
],
[
[
1213,
63,
1555
],
[
1555,
24,
1136
]
],
[
[
1213,
64,
1377
],
[
1377,
24,
1136
]
],
[
[
1213,
25,
39
],
[
39,
... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Denosumab"
]
],
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin"
],
[
... | Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Denosumab
Dasatinib may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may cause... |
DB00586 | DB11943 | 1,512 | 255 | [
"DDInter537",
"DDInter495"
] | Diclofenac | Delafloxacin | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in t... | Moderate | 1 | [
[
[
1512,
24,
255
]
],
[
[
1512,
24,
372
],
[
372,
23,
255
]
],
[
[
1512,
63,
482
],
[
482,
23,
255
]
],
[
[
1512,
24,
1479
],
[
1479,
... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Delafloxacin"
]
],
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
],
[... | Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine may cause a minor interaction that can limit clinical effects when taken with Delafloxacin
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine and Tiog... |
DB00278 | DB15035 | 291 | 503 | [
"DDInter117",
"DDInter1959"
] | Argatroban | Zanubrutinib | Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant sh... | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Major | 2 | [
[
[
291,
25,
503
]
],
[
[
291,
24,
222
],
[
222,
24,
503
]
],
[
[
291,
63,
599
],
[
599,
24,
503
]
],
[
[
291,
25,
39
],
[
39,
25,
... | [
[
[
"Argatroban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Argatroban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"Sibutra... | Argatroban may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Argatroban may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab and A... |
DB00207 | DB00757 | 1,570 | 1,166 | [
"DDInter157",
"DDInter581"
] | Azithromycin | Dolasetron | Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It was initially approved by the FDA in 1991. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually tra... | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Major | 2 | [
[
[
1570,
25,
1166
]
],
[
[
1570,
6,
8374
],
[
8374,
45,
1166
]
],
[
[
1570,
21,
28803
],
[
28803,
60,
1166
]
],
[
[
1570,
23,
112
],
[
11... | [
[
[
"Azithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dolasetron"
]
],
[
[
"Azithromycin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Dol... | Azithromycin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dolasetron (Compound)
Azithromycin (Compound) causes Anaemia (Side Effect) and Anaemia (Side Effect) is caused by Dolasetron (Compound)
Azithromycin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and M... |
DB00055 | DB00749 | 834 | 59 | [
"DDInter605",
"DDInter699"
] | Drotrecogin alfa | Etodolac | Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated th... | Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. | Major | 2 | [
[
[
834,
25,
59
]
],
[
[
834,
64,
25
],
[
25,
24,
59
]
],
[
[
834,
25,
1018
],
[
1018,
24,
59
]
],
[
[
834,
24,
1039
],
[
1039,
63,
... | [
[
[
"Drotrecogin alfa",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etodolac"
]
],
[
[
"Drotrecogin alfa",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Anistreplase"
],
[
"Anistreplase"... | Drotrecogin alfa may lead to a major life threatening interaction when taken with Anistreplase and Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Etodolac
Drotrecogin alfa may lead to a major life threatening interaction when taken with Ticlopidine and Ticlopidine may cause... |
DB01088 | DB06754 | 714 | 707 | [
"DDInter908",
"DDInter471"
] | Iloprost | Danaparoid | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans . The active constituents are heparan, dermatan and , and they are isolated from the porcine intestinal mucosa [FDA Label]. Danaparoid possesses a potent antithrombic activity t... | Major | 2 | [
[
[
714,
25,
707
]
],
[
[
714,
23,
944
],
[
944,
62,
707
]
],
[
[
714,
63,
863
],
[
863,
24,
707
]
],
[
[
714,
24,
1004
],
[
1004,
6... | [
[
[
"Iloprost",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Danaparoid"
]
],
[
[
"Iloprost",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile",
... | Iloprost may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Danaparoid
Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Amiloride and Amiloride may cau... |
DB00550 | DB13074 | 99 | 877 | [
"DDInter1541",
"DDInter1110"
] | Propylthiouracil | Macimorelin | A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534) | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Moderate | 1 | [
[
[
99,
24,
877
]
],
[
[
99,
24,
116
],
[
116,
24,
877
]
],
[
[
99,
24,
996
],
[
996,
25,
877
]
],
[
[
99,
63,
322
],
[
322,
25,
... | [
[
[
"Propylthiouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Macimorelin"
]
],
[
[
"Propylthiouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
... | Propylthiouracil may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131 and Iodide I-131 may cause a moderate interaction that could exacerbate diseases when taken with Macimorelin
Propylthiouracil may cause a moderate interaction that could exacerbate diseases when taken with Beda... |
DB00836 | DB06402 | 543 | 1,079 | [
"DDInter1088",
"DDInter1756"
] | Loperamide | Telavancin | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria. MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and skin and sub... | Moderate | 1 | [
[
[
543,
24,
1079
]
],
[
[
543,
21,
28680
],
[
28680,
60,
1079
]
],
[
[
543,
24,
112
],
[
112,
23,
1079
]
],
[
[
543,
63,
1181
],
[
1181,
... | [
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telavancin"
]
],
[
[
"Loperamide",
"{u} (Compound) causes {v} (Side Effect)",
"Rash"
],
[
"Rash",
"{u} (Side Effect) is caused by {v} ... | Loperamide (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Telavancin (Compound)
Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Telavancin
Lo... |
DB06448 | DB11703 | 171 | 405 | [
"DDInter1087",
"DDInter9"
] | Lonafarnib | Acalabrutinib | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Major | 2 | [
[
[
171,
25,
405
]
],
[
[
171,
63,
1051
],
[
1051,
24,
405
]
],
[
[
171,
25,
1446
],
[
1446,
24,
405
]
],
[
[
171,
25,
982
],
[
982,
... | [
[
[
"Lonafarnib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Lonafarnib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aminoglutethimide"
],
[
"... | Lonafarnib may cause a moderate interaction that could exacerbate diseases when taken with Aminoglutethimide and Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Lonafarnib may lead to a major life threatening interaction when taken with Lanreotide and Lanr... |
DB00397 | DB06204 | 1,466 | 768 | [
"DDInter1458",
"DDInter1746"
] | Phenylpropanolamine | Tapentadol | Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. | Tapentadol is a centrally-acting synthetic analgesic with a dual mechanism of action. It is a mu-opioid receptor agonist that also inhibits norepinephrine reuptake.[A260721, A36596] Tapentadol was first approved by the FDA on November 20, 2008. The extended-release formulation of tapentadol was also approved by the FDA... | Major | 2 | [
[
[
1466,
25,
768
]
],
[
[
1466,
1,
1357
],
[
1357,
1,
768
]
],
[
[
1466,
6,
7390
],
[
7390,
45,
768
]
],
[
[
1466,
21,
28921
],
[
28921,
... | [
[
[
"Phenylpropanolamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tapentadol"
]
],
[
[
"Phenylpropanolamine",
"{u} (Compound) resembles {v} (Compound)",
"Metaraminol"
],
[
"Metaraminol",
"{u} (Compound) res... | Phenylpropanolamine (Compound) resembles Metaraminol (Compound) and Metaraminol (Compound) resembles Tapentadol (Compound)
Phenylpropanolamine (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Tapentadol (Compound)
Phenylpropanolamine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is c... |
DB01073 | DB06414 | 1,488 | 655 | [
"DDInter745",
"DDInter703"
] | Fludarabine | Etravirine | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Moderate | 1 | [
[
[
1488,
24,
655
]
],
[
[
1488,
21,
28723
],
[
28723,
60,
655
]
],
[
[
1488,
63,
168
],
[
168,
23,
655
]
],
[
[
1488,
64,
1057
],
[
1057,... | [
[
[
"Fludarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
]
],
[
[
"Fludarabine",
"{u} (Compound) causes {v} (Side Effect)",
"Malnutrition"
],
[
"Malnutrition",
"{u} (Side Effect)... | Fludarabine (Compound) causes Malnutrition (Side Effect) and Malnutrition (Side Effect) is caused by Etravirine (Compound)
Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with E... |
DB00486 | DB00842 | 1,614 | 686 | [
"DDInter1253",
"DDInter1359"
] | Nabilone | Oxazepam | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Oxazepam is an intermediate-acting, 3-hydroxybenzodiazepine used in the treatment of alcohol withdrawal and anxiety disorders. Oxazepam, like related 3-hydroxybenzodiazepine [lorazepam], is considered less susceptible to pharmacokinetic variability based on patient-specific factors (e.g. age, liver disease) - this feat... | Moderate | 1 | [
[
[
1614,
24,
686
]
],
[
[
1614,
63,
695
],
[
695,
40,
686
]
],
[
[
1614,
24,
1563
],
[
1563,
40,
686
]
],
[
[
1614,
63,
1119
],
[
1119,
... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxazepam"
]
],
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clozapine"
],
[
"Cl... | Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Clozapine and Clozapine (Compound) resembles Oxazepam (Compound)
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Halazepam and Halazepam (Compound) resembles Oxazepam (Compound)
Nabilone may... |
DB00207 | DB14568 | 1,570 | 982 | [
"DDInter157",
"DDInter1000"
] | Azithromycin | Ivosidenib | Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It was initially approved by the FDA in 1991. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually tra... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
1570,
25,
982
]
],
[
[
1570,
23,
112
],
[
112,
23,
982
]
],
[
[
1570,
24,
543
],
[
543,
24,
982
]
],
[
[
1570,
23,
1135
],
[
1135,
... | [
[
[
"Azithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Azithromycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metro... | Azithromycin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and ... |
DB00379 | DB04868 | 143 | 478 | [
"DDInter1206",
"DDInter1293"
] | Mexiletine | Nilotinib | Antiarrhythmic agent pharmacologically similar to lidocaine. It may have some anticonvulsant properties. | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Moderate | 1 | [
[
[
143,
24,
478
]
],
[
[
143,
6,
8374
],
[
8374,
45,
478
]
],
[
[
143,
21,
28762
],
[
28762,
60,
478
]
],
[
[
143,
24,
259
],
[
259,
... | [
[
[
"Mexiletine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]
],
[
[
"Mexiletine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Mexiletine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nilotinib (Compound)
Mexiletine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Nilotinib (Compound)
Mexiletine may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonace... |
DB00013 | DB06779 | 1,255 | 365 | [
"DDInter1905",
"DDInter470"
] | Urokinase | Dalteparin | Urokinase is an endogenous peptide that is cleaved in the presence of plasmin between lysine 158 and isoleucine 159 to yield active urokinase. Urokinase remains connected between these 2 chains by a sulfhydryl bond. Urokinase was granted FDA approval on 16 January 1978. | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Major | 2 | [
[
[
1255,
25,
365
]
],
[
[
1255,
23,
539
],
[
539,
62,
365
]
],
[
[
1255,
24,
954
],
[
954,
24,
365
]
],
[
[
1255,
24,
1496
],
[
1496,
... | [
[
[
"Urokinase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dalteparin"
]
],
[
[
"Urokinase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsicum",
... | Urokinase may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Dalteparin
Urokinase may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril may cau... |
DB00014 | DB09083 | 521 | 880 | [
"DDInter839",
"DDInter996"
] | Goserelin | Ivabradine | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus r... | Major | 2 | [
[
[
521,
25,
880
]
],
[
[
521,
24,
480
],
[
480,
24,
880
]
],
[
[
521,
25,
1011
],
[
1011,
24,
880
]
],
[
[
521,
25,
39
],
[
39,
25,... | [
[
[
"Goserelin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivabradine"
]
],
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
[
"Formoterol",... | Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Ivabradine
Goserelin may lead to a major life threatening interaction when taken with Fingolimod and Fingolimod may cause a ... |
DB00570 | DB00582 | 147 | 1,622 | [
"DDInter1936",
"DDInter1946"
] | Vinblastine | Voriconazole | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Major | 2 | [
[
[
147,
25,
1622
]
],
[
[
147,
6,
8374
],
[
8374,
45,
1622
]
],
[
[
147,
21,
28852
],
[
28852,
60,
1622
]
],
[
[
147,
24,
112
],
[
112,
... | [
[
[
"Vinblastine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Voriconazole"
]
],
[
[
"Vinblastine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Vor... | Vinblastine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Voriconazole (Compound)
Vinblastine (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Voriconazole (Compound)
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Metronidaz... |
DB00366 | DB01409 | 1,594 | 1,415 | [
"DDInter600",
"DDInter1815"
] | Doxylamine | Tiotropium | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Tiotropium is a long-acting, antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma.[A180163,L7084,L7087,L7090,L7093] Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and bronchodilation.[A180163,L7084,L... | Moderate | 1 | [
[
[
1594,
24,
1415
]
],
[
[
1594,
6,
7992
],
[
7992,
45,
1415
]
],
[
[
1594,
21,
28680
],
[
28680,
60,
1415
]
],
[
[
1594,
24,
146
],
[
14... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tiotropium"
]
],
[
[
"Doxylamine",
"{u} (Compound) binds {v} (Gene)",
"CHRM1"
],
[
"CHRM1",
"{u} (Gene) is bound by {v} (Compound)",
... | Doxylamine (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Tiotropium (Compound)
Doxylamine (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Tiotropium (Compound)
Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Propiomazine and Propiomazine m... |
DB00619 | DB04845 | 1,419 | 309 | [
"DDInter909",
"DDInter1001"
] | Imatinib | Ixabepilone | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Moderate | 1 | [
[
[
1419,
24,
309
]
],
[
[
1419,
6,
8374
],
[
8374,
45,
309
]
],
[
[
1419,
21,
28736
],
[
28736,
60,
309
]
],
[
[
1419,
24,
60
],
[
60,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
]
],
[
[
"Imatinib",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Imatinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ixabepilone (Compound)
Imatinib (Compound) causes Dehydration (Side Effect) and Dehydration (Side Effect) is caused by Ixabepilone (Compound)
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Capecitabine and Ca... |
DB00951 | DB01229 | 1,072 | 973 | [
"DDInter986",
"DDInter1377"
] | Isoniazid | Paclitaxel | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Moderate | 1 | [
[
[
1072,
24,
973
]
],
[
[
1072,
24,
310
],
[
310,
63,
973
]
],
[
[
1072,
6,
8374
],
[
8374,
45,
973
]
],
[
[
1072,
21,
28835
],
[
28835,
... | [
[
[
"Isoniazid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Isoniazid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Isoniazid may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Isoniazid (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Paclitaxel (Compound)
Isoniazid (Compoun... |
DB00814 | DB09280 | 1,171 | 1,604 | [
"DDInter1143",
"DDInter1101"
] | Meloxicam | Lumacaftor | Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is ... | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Moderate | 1 | [
[
[
1171,
24,
1604
]
],
[
[
1171,
63,
1061
],
[
1061,
24,
1604
]
],
[
[
1171,
25,
292
],
[
292,
24,
1604
]
],
[
[
1171,
24,
473
],
[
473,
... | [
[
[
"Meloxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lumacaftor"
]
],
[
[
"Meloxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
[
... | Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Lumacaftor
Meloxicam may lead to a major life threatening interaction when taken with Regorafenib and Regorafenib may ca... |
DB00980 | DB12332 | 969 | 1,619 | [
"DDInter1564",
"DDInter1626"
] | Ramelteon | Rucaparib | Ramelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors in the suprachiasmatic nucleus (SCN). It is used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has shown no potential for abuse. | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
969,
24,
1619
]
],
[
[
969,
24,
222
],
[
222,
23,
1619
]
],
[
[
969,
63,
1419
],
[
1419,
24,
1619
]
],
[
[
969,
24,
1362
],
[
1362,
... | [
[
[
"Ramelteon",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Ramelteon",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Ramelteon may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Ramelteon may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib ma... |
DB00001 | DB10344 | 1,578 | 992 | [
"DDInter1037",
"DDInter818"
] | Lepirudin | Ginger | Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor.[L41539,L41569] Natural hirudin is an endogenous anticoagulant found in _Hirudo medicinalis_ leeches. Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence o... | Ginger allergenic extract is used in allergenic testing. | Moderate | 1 | [
[
[
1578,
24,
992
]
],
[
[
1578,
25,
1421
],
[
1421,
63,
992
]
],
[
[
1578,
25,
1167
],
[
1167,
24,
992
]
],
[
[
1578,
24,
1479
],
[
1479,... | [
[
[
"Lepirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginger"
]
],
[
[
"Lepirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betrixaban"
],
[
"Betrixaban",
... | Lepirudin may lead to a major life threatening interaction when taken with Betrixaban and Betrixaban may cause a moderate interaction that could exacerbate diseases when taken with Ginger
Lepirudin may lead to a major life threatening interaction when taken with Streptokinase and Streptokinase may cause a moderate inte... |
DB00655 | DB00741 | 559 | 167 | [
"DDInter682",
"DDInter885"
] | Estrone | Hydrocortisone | Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion... | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Moderate | 1 | [
[
[
559,
24,
167
]
],
[
[
559,
1,
11385
],
[
11385,
40,
167
]
],
[
[
559,
24,
1220
],
[
1220,
40,
167
]
],
[
[
559,
63,
175
],
[
175,
... | [
[
[
"Estrone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
]
],
[
[
"Estrone",
"{u} (Compound) resembles {v} (Compound)",
"Formestane"
],
[
"Formestane",
"{u} (Compound) resembles ... | Estrone (Compound) resembles Formestane (Compound) and Formestane (Compound) resembles Hydrocortisone (Compound)
Estrone may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Hydrocortisone (Compound)
Estrone may cause a moderate interaction... |
DB00450 | DB00514 | 78 | 506 | [
"DDInter603",
"DDInter527"
] | Droperidol | Dextromethorphan | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Moderate | 1 | [
[
[
78,
24,
506
]
],
[
[
78,
21,
28691
],
[
28691,
60,
506
]
],
[
[
78,
63,
13
],
[
13,
24,
506
]
],
[
[
78,
24,
717
],
[
717,
63,
... | [
[
[
"Droperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextromethorphan"
]
],
[
[
"Droperidol",
"{u} (Compound) causes {v} (Side Effect)",
"Somnolence"
],
[
"Somnolence",
"{u} (Side Effect)... | Droperidol (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Dextromethorphan (Compound)
Droperidol may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when ta... |
DB00773 | DB01097 | 896 | 1,377 | [
"DDInter702",
"DDInter1033"
] | Etoposide | Leflunomide | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
896,
25,
1377
]
],
[
[
896,
6,
7950
],
[
7950,
45,
1377
]
],
[
[
896,
18,
17017
],
[
17017,
57,
1377
]
],
[
[
896,
21,
29062
],
[
2906... | [
[
[
"Etoposide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Etoposide",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
"Leflunom... | Etoposide (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Leflunomide (Compound)
Etoposide (Compound) downregulates CD320 (Gene) and CD320 (Gene) is downregulated by Leflunomide (Compound)
Etoposide (Compound) causes Neutropenia (Side Effect) and Neutropenia (Side Effect) is caused by Leflunomide (Compound... |
DB10344 | DB12364 | 992 | 1,421 | [
"DDInter818",
"DDInter200"
] | Ginger | Betrixaban | Ginger allergenic extract is used in allergenic testing. | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Moderate | 1 | [
[
[
992,
24,
1421
]
],
[
[
992,
63,
1593
],
[
1593,
24,
1421
]
],
[
[
992,
63,
1347
],
[
1347,
25,
1421
]
],
[
[
992,
24,
405
],
[
405,
... | [
[
[
"Ginger",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betrixaban"
]
],
[
[
"Ginger",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
],
[
"Cri... | Ginger may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Ginger may cause a moderate interaction that could exacerbate diseases when taken with Clopidogrel and Clopidogrel m... |
DB01177 | DB04946 | 77 | 924 | [
"DDInter904",
"DDInter907"
] | Idarubicin | Iloperidone | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Major | 2 | [
[
[
77,
25,
924
]
],
[
[
77,
63,
1664
],
[
1664,
1,
924
]
],
[
[
77,
64,
1425
],
[
1425,
25,
924
]
],
[
[
77,
24,
519
],
[
519,
40,
... | [
[
[
"Idarubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iloperidone"
]
],
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
[
"Risperid... | Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Iloperidone (Compound)
Idarubicin may lead to a major life threatening interaction when taken with Cisapride and Cisapride may lead to a major life threatening interaction when tak... |
DB00252 | DB08816 | 362 | 578 | [
"DDInter1460",
"DDInter1802"
] | Phenytoin | Ticagrelor | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Major | 2 | [
[
[
362,
25,
578
]
],
[
[
362,
6,
4973
],
[
4973,
45,
578
]
],
[
[
362,
21,
28645
],
[
28645,
60,
578
]
],
[
[
362,
25,
1135
],
[
1135,
... | [
[
[
"Phenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ticagrelor"
]
],
[
[
"Phenytoin",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Ticagrelor"... | Phenytoin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Ticagrelor (Compound)
Phenytoin (Compound) causes Cough (Side Effect) and Cough (Side Effect) is caused by Ticagrelor (Compound)
Phenytoin may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor inter... |
DB01249 | DB05260 | 258 | 1,329 | [
"DDInter958",
"DDInter804"
] | Iodixanol | Gallium nitrate | Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents. | Gallium nitrate is a nitrate salt of , a heavy metal that has been used as a diagnostic agent. Gallium nitrate is reported to possess antiresorptive and hypocalcemic effects on bone. GANITE, a product of gallium nitrate previously used to treat cancer-related hypercalcemia, was discontinued from marketing in the US for... | Major | 2 | [
[
[
258,
25,
1329
]
],
[
[
258,
21,
29035
],
[
29035,
60,
1329
]
],
[
[
258,
25,
712
],
[
712,
24,
1329
]
],
[
[
258,
64,
50
],
[
50,
... | [
[
[
"Iodixanol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gallium nitrate"
]
],
[
[
"Iodixanol",
"{u} (Compound) causes {v} (Side Effect)",
"Hearing impaired"
],
[
"Hearing impaired",
"{u} (Side Effect) is ca... | Iodixanol (Compound) causes Hearing impaired (Side Effect) and Hearing impaired (Side Effect) is caused by Gallium nitrate (Compound)
Iodixanol may lead to a major life threatening interaction when taken with Olsalazine and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Galli... |
DB00902 | DB11632 | 104 | 580 | [
"DDInter1168",
"DDInter1343"
] | Methdilazine | Opicapone | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Opicapone is a potent, reversible, and peripherally-acting third-generation inhibitor of catechol-o-methyltransferase (COMT), an enzyme involved in the breakdown of various catecholamines including dopamine.[A36938, A203048] Many patients with Parkinson’s disease treated with levodopa plus a dopa decarboxylase (DDC) in... | Moderate | 1 | [
[
[
104,
24,
580
]
],
[
[
104,
1,
830
],
[
830,
24,
580
]
],
[
[
104,
24,
401
],
[
401,
24,
580
]
],
[
[
104,
63,
1233
],
[
1233,
24... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opicapone"
]
],
[
[
"Methdilazine",
"{u} (Compound) resembles {v} (Compound)",
"Phenindamine"
],
[
"Phenindamine",
"{u} may cause a ... | Methdilazine (Compound) resembles Phenindamine (Compound) and Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Opicapone
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction... |
DB01166 | DB06414 | 477 | 655 | [
"DDInter379",
"DDInter703"
] | Cilostazol | Etravirine | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Moderate | 1 | [
[
[
477,
24,
655
]
],
[
[
477,
24,
786
],
[
786,
40,
655
]
],
[
[
477,
6,
10215
],
[
10215,
45,
655
]
],
[
[
477,
21,
28883
],
[
28883,
... | [
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
]
],
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilpivirine"
],
[
... | Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Rilpivirine and Rilpivirine (Compound) resembles Etravirine (Compound)
Cilostazol (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Etravirine (Compound)
Cilostazol (Compound) causes Skin disorder (Side Effect) and S... |
DB00186 | DB00341 | 905 | 1,242 | [
"DDInter1092",
"DDInter343"
] | Lorazepam | Cetirizine | Lorazepam is a short-acting and rapidly cleared benzodiazepine used commonly as a sedative and anxiolytic. It was developed by DJ Richards, presented and marketed initially by Wyeth Pharmaceuticals in the USA in 1977. The first historic FDA label approval is reported in 1985 by the company Mutual Pharm. | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms , . One of the most common uses for this drug is for a condition called _alle... | Moderate | 1 | [
[
[
905,
24,
1242
]
],
[
[
905,
21,
29323
],
[
29323,
60,
1242
]
],
[
[
905,
23,
1031
],
[
1031,
23,
1242
]
],
[
[
905,
40,
686
],
[
686,
... | [
[
[
"Lorazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cetirizine"
]
],
[
[
"Lorazepam",
"{u} (Compound) causes {v} (Side Effect)",
"Paralysis"
],
[
"Paralysis",
"{u} (Side Effect) is caused... | Lorazepam (Compound) causes Paralysis (Side Effect) and Paralysis (Side Effect) is caused by Cetirizine (Compound)
Lorazepam may cause a minor interaction that can limit clinical effects when taken with Theophylline and Theophylline may cause a minor interaction that can limit clinical effects when taken with Cetirizin... |
DB00609 | DB00631 | 595 | 372 | [
"DDInter694",
"DDInter405"
] | Ethionamide | Clofarabine | A second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868) | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Moderate | 1 | [
[
[
595,
24,
372
]
],
[
[
595,
24,
1488
],
[
1488,
40,
372
]
],
[
[
595,
21,
28787
],
[
28787,
60,
372
]
],
[
[
595,
63,
1560
],
[
1560,
... | [
[
[
"Ethionamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
]
],
[
[
"Ethionamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
],
... | Ethionamide may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine and Fludarabine (Compound) resembles Clofarabine (Compound)
Ethionamide (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Clofarabine (Compound)
Ethionamide may cause a moderate int... |
DB01254 | DB11793 | 1,213 | 738 | [
"DDInter484",
"DDInter1297"
] | Dasatinib | Niraparib | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
1213,
24,
738
]
],
[
[
1213,
63,
1253
],
[
1253,
24,
738
]
],
[
[
1213,
64,
1578
],
[
1578,
24,
738
]
],
[
[
1213,
24,
496
],
[
496,
... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palifermin"
],
[
... | Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Palifermin and Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Dasatinib may lead to a major life threatening interaction when taken with Lepirudin and Lepirudin may cause a mod... |
DB01281 | DB04865 | 881 | 4 | [
"DDInter5",
"DDInter1335"
] | Abatacept | Omacetaxine mepesuccinate | Abatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1).[L20504,L42715] Structurally, abatacept is a glycosylated fusion protein with a MALDI-MS mo... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
881,
24,
4
]
],
[
[
881,
24,
496
],
[
496,
63,
4
]
],
[
[
881,
63,
66
],
[
66,
24,
4
]
],
[
[
881,
25,
1583
],
[
1583,
63,
... | [
[
[
"Abatacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Abatacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Va... | Abatacept may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine and Hepatitis A Vaccine may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate
Abatacept may cause a moderate interaction that could exacerbate diseases when t... |
DB01059 | DB09080 | 956 | 144 | [
"DDInter1313",
"DDInter1331"
] | Norfloxacin | Olodaterol | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
956,
24,
144
]
],
[
[
956,
25,
1011
],
[
1011,
24,
144
]
],
[
[
956,
64,
11
],
[
11,
24,
144
]
],
[
[
956,
63,
543
],
[
543,
24,... | [
[
[
"Norfloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Norfloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
],
[
"Fingolim... | Norfloxacin may lead to a major life threatening interaction when taken with Fingolimod and Fingolimod may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Norfloxacin may lead to a major life threatening interaction when taken with Toremifene and Toremifene may cause a moderate in... |
DB01041 | DB04865 | 770 | 4 | [
"DDInter1789",
"DDInter1335"
] | Thalidomide | Omacetaxine mepesuccinate | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
770,
24,
4
]
],
[
[
770,
6,
3271
],
[
3271,
46,
4
]
],
[
[
770,
7,
3163
],
[
3163,
46,
4
]
],
[
[
770,
18,
20113
],
[
20113,
46,... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Thalidomide",
"{u} (Compound) binds {v} (Gene)",
"NFKB1"
],
[
"NFKB1",
"{u} (Gene) is upregulate... | Thalidomide (Compound) binds NFKB1 (Gene) and NFKB1 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Thalidomide (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Thalidomide (Compound) downregulates IER3 (Gene) and IER3 (Gene) is upregulated by... |
DB00776 | DB00835 | 1,335 | 100 | [
"DDInter1360",
"DDInter245"
] | Oxcarbazepine | Brompheniramine | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Moderate | 1 | [
[
[
1335,
24,
100
]
],
[
[
1335,
24,
832
],
[
832,
24,
100
]
],
[
[
1335,
40,
508
],
[
508,
24,
100
]
],
[
[
1335,
63,
128
],
[
128,
... | [
[
[
"Oxcarbazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
]
],
[
[
"Oxcarbazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
... | Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine
Oxcarbazepine (Compound) resembles Promazine (Compound) and Promazine may cause a moderate inter... |
DB00860 | DB01208 | 891 | 945 | [
"DDInter1513",
"DDInter1705"
] | Prednisolone | Sparfloxacin | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Major | 2 | [
[
[
891,
25,
945
]
],
[
[
891,
25,
739
],
[
739,
1,
945
]
],
[
[
891,
64,
1176
],
[
1176,
1,
945
]
],
[
[
891,
6,
4973
],
[
4973,
45... | [
[
[
"Prednisolone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sparfloxacin"
]
],
[
[
"Prednisolone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomefloxacin"
],
[
"Lomefloxacin",
... | Prednisolone may lead to a major life threatening interaction when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Sparfloxacin (Compound)
Prednisolone may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Sparfloxacin (Compound)
Prednisolone (... |
DB00261 | DB00526 | 702 | 1,555 | [
"DDInter93",
"DDInter1355"
] | Anagrelide | Oxaliplatin | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Major | 2 | [
[
[
702,
25,
1555
]
],
[
[
702,
6,
7950
],
[
7950,
45,
1555
]
],
[
[
702,
23,
1247
],
[
1247,
62,
1555
]
],
[
[
702,
24,
97
],
[
97,
... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Oxaliplatin"
]
],
[
[
"Anagrelide",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
"Oxalip... | Anagrelide (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Oxaliplatin (Compound)
Anagrelide may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Oxaliplatin
Anagreli... |
DB00193 | DB01105 | 534 | 222 | [
"DDInter1841",
"DDInter1665"
] | Tramadol | Sibutramine | Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatmen... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Major | 2 | [
[
[
534,
25,
222
]
],
[
[
534,
6,
8374
],
[
8374,
45,
222
]
],
[
[
534,
21,
28737
],
[
28737,
60,
222
]
],
[
[
534,
24,
600
],
[
600,
... | [
[
[
"Tramadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
]
],
[
[
"Tramadol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Sibutramin... | Tramadol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sibutramine (Compound)
Tramadol (Compound) causes Bursitis (Side Effect) and Bursitis (Side Effect) is caused by Sibutramine (Compound)
Tramadol may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazo... |
DB01227 | DB08871 | 1,301 | 36 | [
"DDInter1043",
"DDInter666"
] | Levacetylmethadol | Eribulin | Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Major | 2 | [
[
[
1301,
25,
36
]
],
[
[
1301,
64,
1424
],
[
1424,
24,
36
]
],
[
[
1301,
24,
28
],
[
28,
63,
36
]
],
[
[
1301,
25,
384
],
[
384,
63... | [
[
[
"Levacetylmethadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eribulin"
]
],
[
[
"Levacetylmethadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Quinine"
],
[
"Quinine",
... | Levacetylmethadol may lead to a major life threatening interaction when taken with Quinine and Quinine may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Levacetylmethadol may cause a moderate interaction that could exacerbate diseases when taken with Bisacodyl and Bisacodyl may ca... |
DB00196 | DB00673 | 600 | 723 | [
"DDInter743",
"DDInter112"
] | Fluconazole | Aprepitant | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Moderate | 1 | [
[
[
600,
24,
723
]
],
[
[
600,
24,
875
],
[
875,
40,
723
]
],
[
[
600,
6,
6799
],
[
6799,
45,
723
]
],
[
[
600,
54,
19146
],
[
19146,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosaprepitant"
],
... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Fosaprepitant and Fosaprepitant (Compound) resembles Aprepitant (Compound)
Fluconazole (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Aprepitant (Compound)
Fluconazole (Compound) is included by Cytochrome P450 3A4 ... |
DB00637 | DB00818 | 1,557 | 898 | [
"DDInter128",
"DDInter1538"
] | Astemizole | Propofol | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associate... | Moderate | 1 | [
[
[
1557,
24,
898
]
],
[
[
1557,
6,
12523
],
[
12523,
45,
898
]
],
[
[
1557,
23,
112
],
[
112,
62,
898
]
],
[
[
1557,
24,
392
],
[
392,
... | [
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propofol"
]
],
[
[
"Astemizole",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
... | Astemizole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Propofol (Compound)
Astemizole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Propofol
Astemizole may cause... |
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