drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB05679 | DB10429 | 1,683 | 200 | [
"DDInter1907",
"DDInter282"
] | Ustekinumab | Candida albicans | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Moderate | 1 | [
[
[
1683,
24,
200
]
],
[
[
1683,
63,
1096
],
[
1096,
24,
200
]
],
[
[
1683,
25,
976
],
[
976,
24,
200
]
],
[
[
1683,
24,
1019
],
[
1019,
... | [
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
]
],
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolic acid"
... | Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid and Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans
Ustekinumab may lead to a major life threatening interaction when taken with Tofacitinib an... |
DB00622 | DB08884 | 1,081 | 796 | [
"DDInter1287",
"DDInter800"
] | Nicardipine | Gadoxetic acid | A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [Pub... | Gadoxetic acid (gadoxetate) is a paramagnetic gadolinium-containing ionic linear contrast agent in which its salt form, gadoxetate disodium, is used for intravenous injection. Ethoxybenzyl diethylenetriaminepentaacetic acid is the moiety that chelates with a gadolinium ion and forms a stable complex with it to make up ... | Moderate | 1 | [
[
[
1081,
24,
796
]
],
[
[
1081,
21,
28714
],
[
28714,
60,
796
]
],
[
[
1081,
40,
376
],
[
376,
24,
796
]
],
[
[
1081,
21,
28714
],
[
2871... | [
[
[
"Nicardipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gadoxetic acid"
]
],
[
[
"Nicardipine",
"{u} (Compound) causes {v} (Side Effect)",
"Asthenia"
],
[
"Asthenia",
"{u} (Side Effect) is ... | Nicardipine (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Gadoxetic acid (Compound)
Nicardipine (Compound) resembles Amlodipine (Compound) and Amlodipine may cause a moderate interaction that could exacerbate diseases when taken with Gadoxetic acid
Nicardipine (Compound) causes Asthen... |
DB00352 | DB01030 | 482 | 869 | [
"DDInter1814",
"DDInter1835"
] | Tioguanine | Topotecan | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Moderate | 1 | [
[
[
482,
24,
869
]
],
[
[
482,
21,
28709
],
[
28709,
60,
869
]
],
[
[
482,
23,
872
],
[
872,
62,
869
]
],
[
[
482,
23,
1467
],
[
1467,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Topotecan"
]
],
[
[
"Tioguanine",
"{u} (Compound) causes {v} (Side Effect)",
"Decreased appetite"
],
[
"Decreased appetite",
"{u} (Sid... | Tioguanine (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Topotecan (Compound)
Tioguanine may cause a minor interaction that can limit clinical effects when taken with Gemifloxacin and Gemifloxacin may cause a minor interaction that can limit clinical effects when t... |
DB00912 | DB09118 | 473 | 1,580 | [
"DDInter1581",
"DDInter1711"
] | Repaglinide | Stiripentol | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Moderate | 1 | [
[
[
473,
24,
1580
]
],
[
[
473,
24,
466
],
[
466,
62,
1580
]
],
[
[
473,
24,
283
],
[
283,
63,
1580
]
],
[
[
473,
63,
168
],
[
168,
... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stiripentol"
]
],
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
... | Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Stiripentol
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and F... |
DB00647 | DB01169 | 675 | 57 | [
"DDInter528",
"DDInter120"
] | Dextropropoxyphene | Arsenic trioxide | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Major | 2 | [
[
[
675,
25,
57
]
],
[
[
675,
6,
8374
],
[
8374,
45,
57
]
],
[
[
675,
23,
112
],
[
112,
23,
57
]
],
[
[
675,
24,
603
],
[
603,
63,
... | [
[
[
"Dextropropoxyphene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
]
],
[
[
"Dextropropoxyphene",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Comp... | Dextropropoxyphene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Arsenic trioxide (Compound)
Dextropropoxyphene may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Arsen... |
DB00215 | DB01191 | 1,230 | 1,039 | [
"DDInter388",
"DDInter518"
] | Citalopram | Dexfenfluramine | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Major | 2 | [
[
[
1230,
25,
1039
]
],
[
[
1230,
6,
6112
],
[
6112,
45,
1039
]
],
[
[
1230,
24,
1046
],
[
1046,
63,
1039
]
],
[
[
1230,
25,
868
],
[
868,... | [
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexfenfluramine"
]
],
[
[
"Citalopram",
"{u} (Compound) binds {v} (Gene)",
"SLC6A4"
],
[
"SLC6A4",
"{u} (Gene) is bound by {v} (Compound)",
"De... | Citalopram (Compound) binds SLC6A4 (Gene) and SLC6A4 (Gene) is bound by Dexfenfluramine (Compound)
Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Caplacizumab and Caplacizumab may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine
Cita... |
DB00635 | DB11071 | 1,573 | 1,004 | [
"DDInter1515",
"DDInter1449"
] | Prednisone | Phenyl salicylate | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Phenyl salicylate is a 2-hydroxybenzoic acid phenyl ester. It is utilized in some manufacturing processes of polymers, lacquers, adhesives, waxes, as well as polishes. It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing salicylate (found in ). Phenyl salicylate ma... | Moderate | 1 | [
[
[
1573,
24,
1004
]
],
[
[
1573,
23,
771
],
[
771,
62,
1004
]
],
[
[
1573,
24,
1411
],
[
1411,
24,
1004
]
],
[
[
1573,
40,
251
],
[
251,
... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyl salicylate"
]
],
[
[
"Prednisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
],
... | Prednisone may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase and Hyaluronidase may cause a minor interaction that can limit clinical effects when taken with Phenyl salicylate
Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide ... |
DB00843 | DB06589 | 479 | 1,250 | [
"DDInter583",
"DDInter1400"
] | Donepezil | Pazopanib | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Minor | 0 | [
[
[
479,
23,
1250
]
],
[
[
479,
6,
12523
],
[
12523,
45,
1250
]
],
[
[
479,
18,
20113
],
[
20113,
46,
1250
]
],
[
[
479,
21,
29203
],
[
29... | [
[
[
"Donepezil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Pazopanib"
]
],
[
[
"Donepezil",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
... | Donepezil (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Pazopanib (Compound)
Donepezil (Compound) downregulates IER3 (Gene) and IER3 (Gene) is upregulated by Pazopanib (Compound)
Donepezil (Compound) causes Aspartate aminotransferase increased (Side Effect) and Aspartate aminotransferase increased (Side ... |
DB04908 | DB08899 | 1,671 | 129 | [
"DDInter741",
"DDInter649"
] | Flibanserin | Enzalutamide | Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Major | 2 | [
[
[
1671,
25,
129
]
],
[
[
1671,
63,
918
],
[
918,
1,
129
]
],
[
[
1671,
63,
147
],
[
147,
24,
129
]
],
[
[
1671,
24,
1320
],
[
1320,
... | [
[
[
"Flibanserin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
]
],
[
[
"Flibanserin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
],
[
"Bica... | Flibanserin may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Flibanserin may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine and Vinblastine may cause a moderate interaction ... |
DB00238 | DB00455 | 188 | 1,601 | [
"DDInter1285",
"DDInter1091"
] | Nevirapine | Loratadine | A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class. | Loratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis. A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st generation counterparts in many clinical situations. | Moderate | 1 | [
[
[
188,
24,
1601
]
],
[
[
188,
6,
8374
],
[
8374,
45,
1601
]
],
[
[
188,
21,
29106
],
[
29106,
60,
1601
]
],
[
[
188,
24,
609
],
[
609,
... | [
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loratadine"
]
],
[
[
"Nevirapine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Nevirapine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Loratadine (Compound)
Nevirapine (Compound) causes Myalgia (Side Effect) and Myalgia (Side Effect) is caused by Loratadine (Compound)
Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clar... |
DB01035 | DB08881 | 1,401 | 868 | [
"DDInter1524",
"DDInter1925"
] | Procainamide | Vemurafenib | A derivative of procaine with less CNS action. | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Major | 2 | [
[
[
1401,
25,
868
]
],
[
[
1401,
6,
12523
],
[
12523,
45,
868
]
],
[
[
1401,
21,
29015
],
[
29015,
60,
868
]
],
[
[
1401,
74,
608
],
[
608... | [
[
[
"Procainamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
]
],
[
[
"Procainamide",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Ve... | Procainamide (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Vemurafenib (Compound)
Procainamide (Compound) causes Eosinophilia (Side Effect) and Eosinophilia (Side Effect) is caused by Vemurafenib (Compound)
Procainamide (Compound) resembles Lidocaine (Compound) and Procainamide may cause a moderate inter... |
DB00353 | DB09054 | 588 | 384 | [
"DDInter1187",
"DDInter905"
] | Methylergometrine | Idelalisib | A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed) | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Major | 2 | [
[
[
588,
25,
384
]
],
[
[
588,
63,
600
],
[
600,
24,
384
]
],
[
[
588,
24,
723
],
[
723,
24,
384
]
],
[
[
588,
24,
412
],
[
412,
63,... | [
[
[
"Methylergometrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idelalisib"
]
],
[
[
"Methylergometrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
],
[
... | Methylergometrine may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Methylergometrine may cause a moderate interaction that could exacerbate diseases when taken with Aprep... |
DB00099 | DB15719 | 440 | 487 | [
"DDInter735",
"DDInter171"
] | Filgrastim | Belantamab mafodotin | Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the seq... | Belantamab mafodotin, or GSK2857916, is an afucosylated monoclonal antibody that targets B cell maturation antigen conjugated to the microtubule disrupter monomethyl auristatin-F (MMAF). Belantamab mafodotin was granted FDA accelerated approval on 5 August 2020 for the treatment of multiple myeloma; however, its manufa... | Moderate | 1 | [
[
[
440,
24,
487
]
],
[
[
440,
24,
4
],
[
4,
24,
487
]
],
[
[
440,
63,
599
],
[
599,
24,
487
]
],
[
[
440,
25,
1064
],
[
1064,
25,
... | [
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Belantamab mafodotin"
]
],
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepes... | Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Belantamab mafodotin
Filgrastim may cause a moderate interaction that could exacerbate diseas... |
DB01599 | DB11718 | 1,232 | 927 | [
"DDInter1523",
"DDInter640"
] | Probucol | Encorafenib | A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993). | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
1232,
24,
927
]
],
[
[
1232,
62,
112
],
[
112,
23,
927
]
],
[
[
1232,
24,
720
],
[
720,
24,
927
]
],
[
[
1232,
63,
1520
],
[
1520,
... | [
[
[
"Probucol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Probucol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Probucol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Encorafenib
Probucol may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil and Minera... |
DB00087 | DB00278 | 599 | 291 | [
"DDInter41",
"DDInter117"
] | Alemtuzumab | Argatroban | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant sh... | Moderate | 1 | [
[
[
599,
24,
291
]
],
[
[
599,
24,
1338
],
[
1338,
63,
291
]
],
[
[
599,
63,
1172
],
[
1172,
25,
291
]
],
[
[
599,
24,
1650
],
[
1650,
... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Argatroban"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meclofenamic acid"
],... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Meclofenamic acid and Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when taken with Argatroban
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Ibrit... |
DB09118 | DB11186 | 1,580 | 1,609 | [
"DDInter1711",
"DDInter1427"
] | Stiripentol | Pentoxyverine | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
1580,
24,
1609
]
],
[
[
1580,
63,
104
],
[
104,
24,
1609
]
],
[
[
1580,
24,
407
],
[
407,
24,
1609
]
],
[
[
1580,
63,
104
],
[
104,
... | [
[
[
"Stiripentol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Stiripentol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
... | Stiripentol may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Stiripentol may cause a moderate interaction that could exacerbate diseases when taken with Opium and Op... |
DB00552 | DB01610 | 1,238 | 248 | [
"DDInter1425",
"DDInter1912"
] | Pentostatin | Valganciclovir | A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases. | Moderate | 1 | [
[
[
1238,
24,
248
]
],
[
[
1238,
24,
563
],
[
563,
1,
248
]
],
[
[
1238,
21,
29209
],
[
29209,
60,
248
]
],
[
[
1238,
74,
141
],
[
141,
... | [
[
[
"Pentostatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valganciclovir"
]
],
[
[
"Pentostatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ganciclovir"
],
... | Pentostatin may cause a moderate interaction that could exacerbate diseases when taken with Ganciclovir and Ganciclovir (Compound) resembles Valganciclovir (Compound)
Pentostatin (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Valganciclovir (Compound)
Pentostatin (Compound) resembles F... |
DB00305 | DB00853 | 377 | 1,686 | [
"DDInter1232",
"DDInter1762"
] | Mitomycin | Temozolomide | Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of _Streptomyces caespitosus_.[L12867,A193419] It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations, RNA and protein synthesis) by cross-linking the complementary strands of th... | Refractory anaplastic astrocytoma (WHO grade III) and Glioblastoma multiforme (WHO grade IV) are primary malignant brain tumours with poor prognosis and limited treatment options. Despite considerable genetic heterogeneity, these tumours often have impaired DNA repair systems, rendering them initially sensitive to alky... | Moderate | 1 | [
[
[
377,
24,
1686
]
],
[
[
377,
7,
3492
],
[
3492,
46,
1686
]
],
[
[
377,
54,
19138
],
[
19138,
15,
1686
]
],
[
[
377,
7,
4893
],
[
4893,
... | [
[
[
"Mitomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Temozolomide"
]
],
[
[
"Mitomycin",
"{u} (Compound) upregulates {v} (Gene)",
"E2F2"
],
[
"E2F2",
"{u} (Gene) is upregulated by {v} (Com... | Mitomycin (Compound) upregulates E2F2 (Gene) and E2F2 (Gene) is upregulated by Temozolomide (Compound)
Mitomycin (Compound) is included by Alkylating Activity (Pharmacologic Class) and Alkylating Activity (Pharmacologic Class) includes Temozolomide (Compound)
Mitomycin (Compound) upregulates S100A13 (Gene) and S100A13 ... |
DB00006 | DB10672 | 942 | 297 | [
"DDInter217",
"DDInter417"
] | Bivalirudin | Clove | Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important t... | Clove allergenic extract is used in allergenic testing. | Minor | 0 | [
[
[
942,
23,
297
]
],
[
[
942,
25,
235
],
[
235,
62,
297
]
],
[
[
942,
24,
578
],
[
578,
23,
297
]
],
[
[
942,
25,
1564
],
[
1564,
2... | [
[
[
"Bivalirudin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
]
],
[
[
"Bivalirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Desirudin"
],
[
"Desirudin",
... | Bivalirudin may lead to a major life threatening interaction when taken with Desirudin and Desirudin may cause a minor interaction that can limit clinical effects when taken with Clove
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a minor... |
DB01118 | DB05812 | 33 | 1,374 | [
"DDInter76",
"DDInter8"
] | Amiodarone | Abiraterone | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Major | 2 | [
[
[
33,
25,
1374
]
],
[
[
33,
6,
12523
],
[
12523,
45,
1374
]
],
[
[
33,
21,
28809
],
[
28809,
60,
1374
]
],
[
[
33,
23,
466
],
[
466,
... | [
[
[
"Amiodarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Abiraterone"
]
],
[
[
"Amiodarone",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Abirat... | Amiodarone (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Abiraterone (Compound)
Amiodarone (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Abiraterone (Compound)
Amiodarone may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Da... |
DB00757 | DB01601 | 1,166 | 833 | [
"DDInter581",
"DDInter1089"
] | Dolasetron | Lopinavir | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Lopinavir is an antiretroviral protease inhibitor used in combination with other antiretrovirals in the treatment of HIV-1 infection. Lopinavir is marketed and administered exclusively in combination with [ritonavir] - this combination, first marketed by Abbott under the brand name Kaletra in 2000, is necessary due to ... | Major | 2 | [
[
[
1166,
25,
833
]
],
[
[
1166,
25,
1327
],
[
1327,
40,
833
]
],
[
[
1166,
6,
6017
],
[
6017,
45,
833
]
],
[
[
1166,
62,
752
],
[
752,
... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lopinavir"
]
],
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Saquinavir"
],
[
"Saquinavir",
"{u} (C... | Dolasetron may lead to a major life threatening interaction when taken with Saquinavir and Saquinavir (Compound) resembles Lopinavir (Compound)
Dolasetron (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Lopinavir (Compound)
Dolasetron may cause a minor interaction that can limit clinical effects when taken... |
DB00443 | DB08882 | 251 | 1,281 | [
"DDInter195",
"DDInter1070"
] | Betamethasone | Linagliptin | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
251,
24,
1281
]
],
[
[
251,
24,
1002
],
[
1002,
1,
1281
]
],
[
[
251,
6,
8374
],
[
8374,
45,
1281
]
],
[
[
251,
21,
30552
],
[
30552,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
],
... | Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Betamethasone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Linagliptin (Compound)
Betamethasone (Compound) causes Diabetic (Side Effect) and... |
DB01097 | DB13179 | 1,377 | 68 | [
"DDInter1033",
"DDInter1882"
] | Leflunomide | Troleandomycin | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | A macrolide antibiotic that is similar to erythromycin. | Major | 2 | [
[
[
1377,
25,
68
]
],
[
[
1377,
64,
1101
],
[
1101,
23,
68
]
],
[
[
1377,
25,
1374
],
[
1374,
23,
68
]
],
[
[
1377,
25,
309
],
[
309,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Troleandomycin"
]
],
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
[
"Bexarotene",
... | Leflunomide may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Troleandomycin
Leflunomide may lead to a major life threatening interaction when taken with Abiraterone and Abiraterone may cause a minor i... |
DB00513 | DB08816 | 191 | 578 | [
"DDInter70",
"DDInter1802"
] | Aminocaproic acid | Ticagrelor | An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties. | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Minor | 0 | [
[
[
191,
23,
578
]
],
[
[
191,
21,
28762
],
[
28762,
60,
578
]
],
[
[
191,
63,
1255
],
[
1255,
24,
578
]
],
[
[
191,
21,
28762
],
[
28762,... | [
[
[
"Aminocaproic acid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ticagrelor"
]
],
[
[
"Aminocaproic acid",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effec... | Aminocaproic acid (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Ticagrelor (Compound)
Aminocaproic acid may cause a moderate interaction that could exacerbate diseases when taken with Urokinase and Urokinase may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00794 | DB11793 | 759 | 738 | [
"DDInter1521",
"DDInter1297"
] | Primidone | Niraparib | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
759,
24,
738
]
],
[
[
759,
25,
466
],
[
466,
63,
738
]
],
[
[
759,
25,
1213
],
[
1213,
24,
738
]
],
[
[
759,
63,
63
],
[
63,
24,... | [
[
[
"Primidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Primidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Darolutamide"
],
[
"Darolutamid... | Primidone may lead to a major life threatening interaction when taken with Darolutamide and Darolutamide may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Primidone may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may cause a moderate inter... |
DB00434 | DB11601 | 13 | 1,270 | [
"DDInter459",
"DDInter1889"
] | Cyproheptadine | Tuberculin purified protein derivative | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The diagnostic test is commonly referred to as the Mantoux test which serves to minimize the risk of transmission of infection with *Mycoba... | Moderate | 1 | [
[
[
13,
24,
1270
]
],
[
[
13,
63,
1242
],
[
1242,
24,
1270
]
],
[
[
13,
24,
1053
],
[
1053,
24,
1270
]
],
[
[
13,
63,
1242
],
[
1242,
... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protein derivative"
]
],
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}"... | Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative
Cyproheptadine may cause a moderate interaction that could exacerbate diseases w... |
DB01105 | DB06700 | 222 | 643 | [
"DDInter1665",
"DDInter511"
] | Sibutramine | Desvenlafaxine | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of ad... | Major | 2 | [
[
[
222,
25,
643
]
],
[
[
222,
64,
1100
],
[
1100,
1,
643
]
],
[
[
222,
6,
7390
],
[
7390,
45,
643
]
],
[
[
222,
54,
19229
],
[
19229,
... | [
[
[
"Sibutramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Desvenlafaxine"
]
],
[
[
"Sibutramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Venlafaxine"
],
[
"Venlafaxine",
... | Sibutramine may lead to a major life threatening interaction when taken with Venlafaxine and Venlafaxine (Compound) resembles Desvenlafaxine (Compound)
Sibutramine (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Desvenlafaxine (Compound)
Sibutramine (Compound) is included by Serotonin Uptake Inhibitors (Ph... |
DB01083 | DB08870 | 1,142 | 850 | [
"DDInter1348",
"DDInter228"
] | Orlistat | Brentuximab vedotin | The global prevalence of obesity is increasing rapidly. Obesity-related complications lead to significant personal and economic burden by reducing quality of life and increasing the cost of healthcare. In some individuals, diet and exercise are insufficient to maintain weight loss, and pharmacological or surgical inter... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
1142,
24,
850
]
],
[
[
1142,
63,
267
],
[
267,
24,
850
]
],
[
[
1142,
24,
1477
],
[
1477,
24,
850
]
],
[
[
1142,
24,
1412
],
[
1412,
... | [
[
[
"Orlistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Orlistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
],
... | Orlistat may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Orlistat may cause a moderate interaction that could exacerbate diseases when taken with Telbivudine and ... |
DB00598 | DB09564 | 1,523 | 1,296 | [
"DDInter1013",
"DDInter930"
] | Labetalol | Insulin degludec | Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture. Labetalol is formulated as an injection or tablets to treat hypertension.[L7727,L7730] Labetalol was granted FDA approval on 1 August 1984. | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
1523,
24,
1296
]
],
[
[
1523,
24,
1411
],
[
1411,
24,
1296
]
],
[
[
1523,
25,
659
],
[
659,
24,
1296
]
],
[
[
1523,
62,
542
],
[
542,
... | [
[
[
"Labetalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Labetalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
],
... | Labetalol may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Labetalol may lead to a major life threatening interaction when taken with Vilanterol and Vilanterol may ... |
DB00445 | DB01255 | 322 | 633 | [
"DDInter655",
"DDInter1078"
] | Epirubicin | Lisdexamfetamine | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Moderate | 1 | [
[
[
322,
24,
633
]
],
[
[
322,
24,
743
],
[
743,
1,
633
]
],
[
[
322,
24,
1523
],
[
1523,
40,
633
]
],
[
[
322,
21,
28751
],
[
28751,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisdexamfetamine"
]
],
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisinopril"
],
... | Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Lisinopril and Lisinopril (Compound) resembles Lisdexamfetamine (Compound)
Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol (Compound) resembles Lisdexamfetamine (... |
DB00607 | DB08875 | 1,249 | 1,618 | [
"DDInter1256",
"DDInter262"
] | Nafcillin | Cabozantinib | A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be u... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Moderate | 1 | [
[
[
1249,
24,
1618
]
],
[
[
1249,
24,
1135
],
[
1135,
62,
1618
]
],
[
[
1249,
24,
723
],
[
723,
24,
1618
]
],
[
[
1249,
24,
384
],
[
384,
... | [
[
[
"Nafcillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabozantinib"
]
],
[
[
"Nafcillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
[
... | Nafcillin may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Nafcillin may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant... |
DB00001 | DB05578 | 1,578 | 330 | [
"DDInter1037",
"DDInter1566"
] | Lepirudin | Ramucirumab | Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor.[L41539,L41569] Natural hirudin is an endogenous anticoagulant found in _Hirudo medicinalis_ leeches. Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence o... | Ramucirumab is a human monoclonal antibody (IgG1) against vascular endothelial growth factor receptor 2 (VEGFR2), a type II trans-membrane tyrosine kinase receptor expressed on endothelial cells. By binding to VEGFR2, ramucirumab prevents binding of its ligands (VEGF-A, VEGF-C, and VEGF-D), thereby preventing VEGF-stim... | Major | 2 | [
[
[
1578,
25,
330
]
],
[
[
1578,
24,
41
],
[
41,
63,
330
]
],
[
[
1578,
24,
901
],
[
901,
24,
330
]
],
[
[
1578,
25,
1317
],
[
1317,
... | [
[
[
"Lepirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ramucirumab"
]
],
[
[
"Lepirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
],
[
"Levomi... | Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran and Levomilnacipran may cause a moderate interaction that could exacerbate diseases when taken with Ramucirumab
Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Milnacipran ... |
DB00072 | DB01229 | 550 | 973 | [
"DDInter1846",
"DDInter1377"
] | Trastuzumab | Paclitaxel | Produced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth factor receptor protein (HER2). It is used as a treatment of human epidermal growth ... | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Moderate | 1 | [
[
[
550,
24,
973
]
],
[
[
550,
24,
748
],
[
748,
63,
973
]
],
[
[
550,
24,
563
],
[
563,
24,
973
]
],
[
[
550,
63,
1257
],
[
1257,
2... | [
[
[
"Trastuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Trastuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
],
... | Trastuzumab may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine and Anthrax vaccine may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Trastuzumab may cause a moderate interaction that could exacerbate diseases when taken with Ganciclov... |
DB00902 | DB09564 | 104 | 1,296 | [
"DDInter1168",
"DDInter930"
] | Methdilazine | Insulin degludec | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
104,
24,
1296
]
],
[
[
104,
63,
274
],
[
274,
23,
1296
]
],
[
[
104,
64,
1621
],
[
1621,
23,
1296
]
],
[
[
104,
63,
17
],
[
17,
... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phentolamine"
... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Phentolamine and Phentolamine may cause a minor interaction that can limit clinical effects when taken with Insulin degludec
Methdilazine may lead to a major life threatening interaction when taken with Potassium chloride and P... |
DB00026 | DB15762 | 1,184 | 725 | [
"DDInter94",
"DDInter1644"
] | Anakinra | Satralizumab | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Satralizumab is a recombinant humanized monoclonal antibody targeted against human interleukin-6 (IL-6) receptors, similar to [tocilizumab], which is produced in Chinese hamster ovary cells and based on an IgG2 framework. Satralizumab is used in the treatment of neuromyelitis optica spectrum disorder (NMOSD), a rare au... | Major | 2 | [
[
[
1184,
25,
725
]
],
[
[
1184,
23,
1193
],
[
1193,
23,
725
]
],
[
[
1184,
24,
1362
],
[
1362,
24,
725
]
],
[
[
1184,
63,
305
],
[
305,
... | [
[
[
"Anakinra",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Satralizumab"
]
],
[
[
"Anakinra",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Zinc gluco... | Anakinra may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Satralizumab
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olapar... |
DB01400 | DB04843 | 1,372 | 1,511 | [
"DDInter1279",
"DDInter1149"
] | Neostigmine | Mepenzolate | A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier. | Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ga... | Moderate | 1 | [
[
[
1372,
24,
1511
]
],
[
[
1372,
63,
1192
],
[
1192,
24,
1511
]
],
[
[
1372,
21,
28722
],
[
28722,
60,
1511
]
],
[
[
1372,
1,
751
],
[
75... | [
[
[
"Neostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
]
],
[
[
"Neostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glycopyrronium"
],
... | Neostigmine may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium and Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Neostigmine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Mepenzolate (... |
DB00252 | DB11995 | 362 | 1,634 | [
"DDInter1460",
"DDInter143"
] | Phenytoin | Avatrombopag | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Avatrombopag (_Doptelet_), is an orally administered, small molecule thrombopoietin receptor (c-Mpl) agonist that increases platelet number without increasing platelet activation,[A33097,L2824] thereby decreasing the need for blood transfusions. Patients with thrombocytopenia and chronic liver disease often require pla... | Major | 2 | [
[
[
362,
25,
1634
]
],
[
[
362,
1,
759
],
[
759,
24,
1634
]
],
[
[
362,
25,
760
],
[
760,
24,
1634
]
],
[
[
362,
24,
609
],
[
609,
2... | [
[
[
"Phenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Avatrombopag"
]
],
[
[
"Phenytoin",
"{u} (Compound) resembles {v} (Compound)",
"Primidone"
],
[
"Primidone",
"{u} may cause a moderate interaction tha... | Phenytoin (Compound) resembles Primidone (Compound) and Primidone may cause a moderate interaction that could exacerbate diseases when taken with Avatrombopag
Phenytoin may lead to a major life threatening interaction when taken with Cobicistat and Cobicistat may cause a moderate interaction that could exacerbate disea... |
DB01181 | DB11730 | 1,532 | 351 | [
"DDInter906",
"DDInter1588"
] | Ifosfamide | Ribociclib | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
1532,
24,
351
]
],
[
[
1532,
24,
1627
],
[
1627,
23,
351
]
],
[
[
1532,
63,
288
],
[
288,
24,
351
]
],
[
[
1532,
24,
987
],
[
987,
... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
],
[
... | Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Butalbital and Butalb... |
DB00397 | DB01365 | 1,466 | 280 | [
"DDInter1458",
"DDInter1151"
] | Phenylpropanolamine | Mephentermine | Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. | A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type depen... | Moderate | 1 | [
[
[
1466,
24,
280
]
],
[
[
1466,
36,
551
],
[
551,
1,
280
]
],
[
[
1466,
63,
80
],
[
80,
40,
280
]
],
[
[
1466,
1,
11216
],
[
11216,
... | [
[
[
"Phenylpropanolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mephentermine"
]
],
[
[
"Phenylpropanolamine",
"{u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when t... | Phenylpropanolamine (Compound) resembles Phenelzine (Compound) and Phenylpropanolamine may lead to a major life threatening interaction when taken with Phenelzine and Phenelzine (Compound) resembles Mephentermine (Compound)
Phenylpropanolamine may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00450 | DB01169 | 78 | 57 | [
"DDInter603",
"DDInter120"
] | Droperidol | Arsenic trioxide | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Major | 2 | [
[
[
78,
25,
57
]
],
[
[
78,
23,
112
],
[
112,
23,
57
]
],
[
[
78,
24,
603
],
[
603,
63,
57
]
],
[
[
78,
24,
480
],
[
480,
24,
... | [
[
[
"Droperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
]
],
[
[
"Droperidol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Met... | Droperidol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Arsenic trioxide
Droperidol may cause a moderate interaction that could exacerbate diseases when taken with Magnesium cit... |
DB00831 | DB11901 | 1,178 | 913 | [
"DDInter1866",
"DDInter107"
] | Trifluoperazine | Apalutamide | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
1178,
24,
913
]
],
[
[
1178,
23,
112
],
[
112,
23,
913
]
],
[
[
1178,
63,
600
],
[
600,
24,
913
]
],
[
[
1178,
24,
28
],
[
28,
2... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Trifluoperazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
... | Trifluoperazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Fluconaz... |
DB01229 | DB11601 | 973 | 1,270 | [
"DDInter1377",
"DDInter1889"
] | Paclitaxel | Tuberculin purified protein derivative | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The diagnostic test is commonly referred to as the Mantoux test which serves to minimize the risk of transmission of infection with *Mycoba... | Moderate | 1 | [
[
[
973,
24,
1270
]
],
[
[
973,
24,
350
],
[
350,
24,
1270
]
],
[
[
973,
63,
550
],
[
550,
24,
1270
]
],
[
[
973,
64,
1064
],
[
1064,
... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protein derivative"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Carfilzomib and Carfilzomib may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative
Paclitaxel may cause a moderate interaction that could exacerbate diseases when ta... |
DB01081 | DB01221 | 1,688 | 1,190 | [
"DDInter571",
"DDInter1007"
] | Diphenoxylate | Ketamine | A meperidine congener used as an antidiarrheal, usually in combination with atropine. At high doses, it acts like morphine. Its unesterified metabolite difenoxin has similar properties and is used similarly. It has little or no analgesic activity. This medication is classified as a Schedule V under the Controlled Subst... | Ketamine is an NMDA receptor antagonist with a potent anesthetic effect. It was developed in 1963 as a replacement for phencyclidine (PCP) by Calvin Stevens at Parke Davis Laboratories. It started being used for veterinary purposes in Belgium and in 1964 was proven that compared to PCP, it produced minor hallucinogenic... | Moderate | 1 | [
[
[
1688,
24,
1190
]
],
[
[
1688,
6,
6291
],
[
6291,
45,
1190
]
],
[
[
1688,
24,
649
],
[
649,
63,
1190
]
],
[
[
1688,
63,
1594
],
[
1594,... | [
[
[
"Diphenoxylate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketamine"
]
],
[
[
"Diphenoxylate",
"{u} (Compound) binds {v} (Gene)",
"OPRD1"
],
[
"OPRD1",
"{u} (Gene) is bound by {v} (Compound)... | Diphenoxylate (Compound) binds OPRD1 (Gene) and OPRD1 (Gene) is bound by Ketamine (Compound)
Diphenoxylate may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Ketamine
Diphenoxylate may ... |
DB06655 | DB08886 | 5 | 637 | [
"DDInter1077",
"DDInter126"
] | Liraglutide | Asparaginase Erwinia chrysanthemi | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Asparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-aspar... | Moderate | 1 | [
[
[
5,
24,
637
]
],
[
[
5,
63,
167
],
[
167,
24,
637
]
],
[
[
5,
24,
850
],
[
850,
24,
637
]
],
[
[
5,
24,
1296
],
[
1296,
63,
... | [
[
[
"Liraglutide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Erwinia chrysanthemi"
]
],
[
[
"Liraglutide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hy... | Liraglutide may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Erwinia chrysanthemi
Liraglutide may cause a moderate interaction that could exacerbate diseases when... |
DB00814 | DB06441 | 1,171 | 936 | [
"DDInter1143",
"DDInter283"
] | Meloxicam | Cangrelor | Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is ... | Cangrelor is an intravenous, direct-acting, reversible P2Y12 inhibitor for patients undergoing percutaneous coronary intervention (PCI) who have not been yet treated by oral P2Y12 inhibitors. An advantage Cangrelor provides over oral P2Y12 inhibitors (such as prasugrel, ticagrelor, and clopidogrel) is that it is an act... | Moderate | 1 | [
[
[
1171,
24,
936
]
],
[
[
1171,
24,
477
],
[
477,
24,
936
]
],
[
[
1171,
63,
305
],
[
305,
24,
936
]
],
[
[
1171,
24,
738
],
[
738,
... | [
[
[
"Meloxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cangrelor"
]
],
[
[
"Meloxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
],
[
... | Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Cilostazol and Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Cangrelor
Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia... |
DB01183 | DB06800 | 173 | 1,159 | [
"DDInter1262",
"DDInter1188"
] | Naloxone | Methylnaltrexone | Naloxone is an opioid antagonist medication used to block or reverse the effects of opioid drugs, particularly within the setting of drug overdoses which are rapidly becoming a leading cause of death worldwide. More specifically, naloxone has a high affinity for μ-opioid receptors, where it acts as an inverse agonist, ... | Methylnaltrexone is a pheriphally-acting μ-opioid antagonist that acts on the gastrointestinal tract to decrease opioid-induced constipation without producing analgesic effects or withdrawal symptoms. It is also a weak CYP2D6 inhibitor. FDA approved in 2008. | Moderate | 1 | [
[
[
173,
35,
1159
]
],
[
[
173,
63,
828
],
[
828,
1,
1159
]
],
[
[
173,
1,
509
],
[
509,
1,
1159
]
],
[
[
173,
35,
560
],
[
560,
1,
... | [
[
[
"Naloxone",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylnaltrexone"
]
],
[
[
"Naloxone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken... | Naloxone (Compound) resembles Methylnaltrexone (Compound) and
Naloxone may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone and Oxycodone (Compound) resembles Methylnaltrexone (Compound)
Naloxone (Compound) resembles Buprenorphine (Compound) and Buprenorphine (Compound) resembles Me... |
DB00252 | DB01050 | 362 | 848 | [
"DDInter1460",
"DDInter900"
] | Phenytoin | Ibuprofen | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Minor | 0 | [
[
[
362,
23,
848
]
],
[
[
362,
6,
1829
],
[
1829,
45,
848
]
],
[
[
362,
21,
29124
],
[
29124,
60,
848
]
],
[
[
362,
25,
752
],
[
752,
... | [
[
[
"Phenytoin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ibuprofen"
]
],
[
[
"Phenytoin",
"{u} (Compound) binds {v} (Gene)",
"ALB"
],
[
"ALB",
"{u} (Gene) is bound by {v} (Compound)",
"Ibu... | Phenytoin (Compound) binds ALB (Gene) and ALB (Gene) is bound by Ibuprofen (Compound)
Phenytoin (Compound) causes Rash pustular (Side Effect) and Rash pustular (Side Effect) is caused by Ibuprofen (Compound)
Phenytoin may lead to a major life threatening interaction when taken with Cimetidine and Cimetidine may cause a... |
DB00350 | DB00443 | 1,214 | 251 | [
"DDInter1226",
"DDInter195"
] | Minoxidil | Betamethasone | A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure. | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Moderate | 1 | [
[
[
1214,
24,
251
]
],
[
[
1214,
24,
617
],
[
617,
40,
251
]
],
[
[
1214,
24,
870
],
[
870,
1,
251
]
],
[
[
1214,
7,
2384
],
[
2384,
... | [
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betamethasone"
]
],
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Budesonide"
],
[
... | Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and Budesonide (Compound) resembles Betamethasone (Compound)
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Betamethaso... |
DB00683 | DB11569 | 1,382 | 1,093 | [
"DDInter1212",
"DDInter1003"
] | Midazolam | Ixekizumab | Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called _benzodiazepines_. This drug is unique from others in this class due to its rapid onset of effects and short duration of action. Midazola... | Ixekizumab is a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody (mAb) against interleukin-17A (IL-17A) and prevents it from interacting with the IL-17A receptor. As IL-17A is a pro-inflammatory cytokine involved in inflammation and immune responses, blocking its effect is beneficial for use in inflamma... | Moderate | 1 | [
[
[
1382,
24,
1093
]
],
[
[
1382,
63,
608
],
[
608,
24,
1093
]
],
[
[
1382,
24,
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],
[
1683,
24,
1093
]
],
[
[
1382,
62,
1031
],
[
1031... | [
[
[
"Midazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixekizumab"
]
],
[
[
"Midazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
... | Midazolam may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Ixekizumab
Midazolam may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinum... |
DB06595 | DB14711 | 1,491 | 779 | [
"DDInter1214",
"DDInter1680"
] | Midostaurin | Smallpox (Vaccinia) Vaccine, Live | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | The New York City Board of Health strain of _Vaccinia_ is a viral strain used as a component of some smallpox vaccinations. ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this strain. | Major | 2 | [
[
[
1491,
25,
779
]
],
[
[
1491,
64,
1064
],
[
1064,
25,
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]
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[
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63,
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],
[
147,
25,
779
]
],
[
[
1491,
25,
1259
],
[
1259,
... | [
[
[
"Midostaurin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Smallpox (Vaccinia) Vaccine, Live"
]
],
[
[
"Midostaurin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[
"... | Midostaurin may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Smallpox (Vaccinia) Vaccine, Live
Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine and Vinblastin... |
DB01129 | DB12267 | 379 | 1,476 | [
"DDInter1559",
"DDInter233"
] | Rabeprazole | Brigatinib | Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion. | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
379,
24,
1476
]
],
[
[
379,
63,
883
],
[
883,
24,
1476
]
],
[
[
379,
25,
1250
],
[
1250,
24,
1476
]
],
[
[
379,
24,
478
],
[
478,
... | [
[
[
"Rabeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Rabeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
... | Rabeprazole may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib
Rabeprazole may lead to a major life threatening interaction when taken with Pazopanib and Pazopanib may cause a ... |
DB00331 | DB00467 | 1,645 | 1,467 | [
"DDInter1164",
"DDInter644"
] | Metformin | Enoxacin | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. | Moderate | 1 | [
[
[
1645,
24,
1467
]
],
[
[
1645,
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],
[
1539,
40,
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]
],
[
[
1645,
24,
1299
],
[
1299,
1,
1467
]
],
[
[
1645,
63,
1176
],
[
117... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enoxacin"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ofloxacin"
],
[
"... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Ofloxacin and Ofloxacin (Compound) resembles Enoxacin (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Trovafloxacin and Trovafloxacin (Compound) resembles Enoxacin (Compound)
Me... |
DB01096 | DB09472 | 678 | 1,383 | [
"DDInter1356",
"DDInter1693"
] | Oxamniquine | Sodium sulfate | An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martidale, The Ex... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
678,
24,
1383
]
],
[
[
678,
24,
673
],
[
673,
24,
1383
]
],
[
[
678,
63,
109
],
[
109,
24,
1383
]
],
[
[
678,
25,
593
],
[
593,
... | [
[
[
"Oxamniquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Oxamniquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aripiprazole"
],
... | Oxamniquine may cause a moderate interaction that could exacerbate diseases when taken with Aripiprazole and Aripiprazole may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Oxamniquine may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine ... |
DB01115 | DB06176 | 336 | 1,342 | [
"DDInter1291",
"DDInter1616"
] | Nifedipine | Romidepsin | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Moderate | 1 | [
[
[
336,
24,
1342
]
],
[
[
336,
24,
1491
],
[
1491,
63,
1342
]
],
[
[
336,
24,
820
],
[
820,
24,
1342
]
],
[
[
336,
63,
51
],
[
51,
... | [
[
[
"Nifedipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romidepsin"
]
],
[
[
"Nifedipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
],
[
... | Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin and Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin
Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Ali... |
DB00563 | DB00582 | 663 | 1,622 | [
"DDInter1174",
"DDInter1946"
] | Methotrexate | Voriconazole | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Moderate | 1 | [
[
[
663,
24,
1622
]
],
[
[
663,
21,
28957
],
[
28957,
60,
1622
]
],
[
[
663,
24,
466
],
[
466,
62,
1622
]
],
[
[
663,
24,
1419
],
[
1419,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Voriconazole"
]
],
[
[
"Methotrexate",
"{u} (Compound) causes {v} (Side Effect)",
"Arthralgia"
],
[
"Arthralgia",
"{u} (Side Effect)... | Methotrexate (Compound) causes Arthralgia (Side Effect) and Arthralgia (Side Effect) is caused by Voriconazole (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken wi... |
DB09074 | DB10316 | 1,362 | 334 | [
"DDInter1327",
"DDInter1248"
] | Olaparib | Mumps virus strain B level jeryl lynn live antigen | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
1362,
25,
334
]
],
[
[
1362,
63,
594
],
[
594,
25,
334
]
],
[
[
1362,
64,
1057
],
[
1057,
25,
334
]
],
[
[
1362,
24,
1619
],
[
1619,
... | [
[
[
"Olaparib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Olaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosuti... | Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Bosutinib and Bosutinib may lead to a major life threatening interaction when taken with Mumps virus strain B level jeryl lynn live antigen
Olaparib may lead to a major life threatening interaction when taken with Etanercept and Et... |
DB00773 | DB01076 | 896 | 700 | [
"DDInter702",
"DDInter133"
] | Etoposide | Atorvastatin | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Moderate | 1 | [
[
[
896,
24,
700
]
],
[
[
896,
24,
1080
],
[
1080,
1,
700
]
],
[
[
896,
6,
4973
],
[
4973,
45,
700
]
],
[
[
896,
7,
2969
],
[
2969,
... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atorvastatin"
]
],
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Conivaptan"
],
[
... | Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Conivaptan and Conivaptan (Compound) resembles Atorvastatin (Compound)
Etoposide (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Atorvastatin (Compound)
Etoposide (Compound) upregulates CDKN1A (Gene) and CDKN1A (Gene) i... |
DB00719 | DB00924 | 1,219 | 1,405 | [
"DDInter149",
"DDInter454"
] | Azatadine | Cyclobenzaprine | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Cyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961 and has been available for human use since 1977. It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from [Amitriptyline] by only a single double bond.[A185039,A184... | Moderate | 1 | [
[
[
1219,
24,
1405
]
],
[
[
1219,
63,
1302
],
[
1302,
1,
1405
]
],
[
[
1219,
24,
358
],
[
358,
1,
1405
]
],
[
[
1219,
24,
401
],
[
401,
... | [
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclobenzaprine"
]
],
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Protriptyline"
],
... | Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Protriptyline and Protriptyline (Compound) resembles Cyclobenzaprine (Compound)
Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Orphenadrine (Compound) resembles Cyclobenz... |
DB00601 | DB00792 | 453 | 832 | [
"DDInter1073",
"DDInter1878"
] | Linezolid | Tripelennamine | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Moderate | 1 | [
[
[
453,
24,
832
]
],
[
[
453,
24,
100
],
[
100,
63,
832
]
],
[
[
453,
25,
1264
],
[
1264,
63,
832
]
],
[
[
453,
64,
1594
],
[
1594,
... | [
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
]
],
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
],
... | Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine
Linezolid may lead to a major life threatening interaction when taken with Doxepin and Doxepin may ... |
DB01206 | DB05273 | 37 | 507 | [
"DDInter1086",
"DDInter1638"
] | Lomustine | Samarium (153Sm) lexidronam | An alkylating agent of value against both hematologic malignancies and solid tumors. | Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.Samarium ... | Major | 2 | [
[
[
37,
25,
507
]
],
[
[
37,
24,
248
],
[
248,
24,
507
]
],
[
[
37,
63,
563
],
[
563,
24,
507
]
],
[
[
37,
24,
270
],
[
270,
63,
... | [
[
[
"Lomustine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Samarium (153Sm) lexidronam"
]
],
[
[
"Lomustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valganciclovir"
],
... | Lomustine may cause a moderate interaction that could exacerbate diseases when taken with Valganciclovir and Valganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Samarium (153Sm) lexidronam
Lomustine may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00622 | DB14568 | 1,081 | 982 | [
"DDInter1287",
"DDInter1000"
] | Nicardipine | Ivosidenib | A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [Pub... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Moderate | 1 | [
[
[
1081,
24,
982
]
],
[
[
1081,
63,
1101
],
[
1101,
23,
982
]
],
[
[
1081,
24,
770
],
[
770,
24,
982
]
],
[
[
1081,
40,
376
],
[
376,
... | [
[
[
"Nicardipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivosidenib"
]
],
[
[
"Nicardipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and Thali... |
DB00367 | DB00400 | 566 | 353 | [
"DDInter1061",
"DDInter843"
] | Levonorgestrel | Griseofulvin | Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of ... | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Major | 2 | [
[
[
566,
25,
353
]
],
[
[
566,
6,
8374
],
[
8374,
45,
353
]
],
[
[
566,
18,
15501
],
[
15501,
57,
353
]
],
[
[
566,
21,
29093
],
[
29093,
... | [
[
[
"Levonorgestrel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Griseofulvin"
]
],
[
[
"Levonorgestrel",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Levonorgestrel (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Griseofulvin (Compound)
Levonorgestrel (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Griseofulvin (Compound)
Levonorgestrel (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Griseofulv... |
DB00970 | DB11943 | 0 | 255 | [
"DDInter466",
"DDInter495"
] | Dactinomycin | Delafloxacin | A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also d... | Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in t... | Minor | 0 | [
[
[
0,
23,
255
]
],
[
[
0,
63,
377
],
[
377,
23,
255
]
],
[
[
0,
24,
995
],
[
995,
23,
255
]
],
[
[
0,
24,
214
],
[
214,
63,
2... | [
[
[
"Dactinomycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Delafloxacin"
]
],
[
[
"Dactinomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mitomycin"
],
[... | Dactinomycin may cause a moderate interaction that could exacerbate diseases when taken with Mitomycin and Mitomycin may cause a minor interaction that can limit clinical effects when taken with Delafloxacin
Dactinomycin may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyurea and Hyd... |
DB06228 | DB14730 | 792 | 1,412 | [
"DDInter1609",
"DDInter264"
] | Rivaroxaban | Calaspargase pegol | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
792,
24,
1412
]
],
[
[
792,
64,
1439
],
[
1439,
24,
1412
]
],
[
[
792,
24,
159
],
[
159,
24,
1412
]
],
[
[
792,
63,
392
],
[
392,
... | [
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Rivaroxaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ipilimumab"
],
[
"... | Rivaroxaban may lead to a major life threatening interaction when taken with Ipilimumab and Ipilimumab may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrec... |
DB00774 | DB06335 | 1,577 | 761 | [
"DDInter889",
"DDInter1646"
] | Hydroflumethiazide | Saxagliptin | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822) | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
1577,
24,
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],
[
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1577,
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],
[
28722,
60,
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[
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1577,
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],
[
104,
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],
[
[
1577,
40,
178
],
[
178,
... | [
[
[
"Hydroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Hydroflumethiazide",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effe... | Hydroflumethiazide (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Saxagliptin (Compound)
Hydroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when tak... |
DB06616 | DB09481 | 594 | 460 | [
"DDInter224",
"DDInter1113"
] | Bosutinib | Magnesium carbonate | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Moderate | 1 | [
[
[
594,
24,
460
]
],
[
[
594,
63,
752
],
[
752,
23,
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]
],
[
[
594,
64,
684
],
[
684,
23,
460
]
],
[
[
594,
24,
1468
],
[
1468,
2... | [
[
[
"Bosutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Bosutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cimetidine"
],
... | Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Bosutinib may lead to a major life threatening interaction when taken with Thioridazine and Thioridazine m... |
DB00387 | DB01075 | 1,386 | 1,376 | [
"DDInter1528",
"DDInter569"
] | Procyclidine | Diphenhydramine | A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism. | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
1386,
24,
1376
]
],
[
[
1386,
24,
649
],
[
649,
63,
1376
]
],
[
[
1386,
24,
128
],
[
128,
24,
1376
]
],
[
[
1386,
63,
1594
],
[
1594,
... | [
[
[
"Procyclidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Procyclidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],... | Procyclidine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Procyclidine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheni... |
DB00514 | DB11823 | 506 | 858 | [
"DDInter527",
"DDInter673"
] | Dextromethorphan | Esketamine | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Major depressive disorder (MDD) is a significant cause of disability worldwide and the most common illness preceding suicide.[L5596,A175462] On March 5, 2019, the nasal spray drug, _esketamine_, also known as _Spravato_ (by Janssen Pharmaceuticals), was approved by the FDA for treatment-resistant major depression. Eske... | Moderate | 1 | [
[
[
506,
24,
858
]
],
[
[
506,
24,
272
],
[
272,
24,
858
]
],
[
[
506,
63,
13
],
[
13,
24,
858
]
],
[
[
506,
63,
73
],
[
73,
25,
... | [
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esketamine"
]
],
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramin... | Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Esketamine
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00867 | DB01234 | 1,052 | 1,220 | [
"DDInter1606",
"DDInter513"
] | Ritodrine | Dexamethasone | Adrenergic beta-agonist used to control premature labor. | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Minor | 0 | [
[
[
1052,
23,
1220
]
],
[
[
1052,
62,
870
],
[
870,
1,
1220
]
],
[
[
1052,
62,
175
],
[
175,
40,
1220
]
],
[
[
1052,
23,
617
],
[
617,
... | [
[
[
"Ritodrine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dexamethasone"
]
],
[
[
"Ritodrine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Fludrocortisone"
],
[
... | Ritodrine may cause a minor interaction that can limit clinical effects when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Ritodrine may cause a minor interaction that can limit clinical effects when taken with Triamcinolone and Triamcinolone (Compound) resembles Dexametha... |
DB00641 | DB09061 | 467 | 1,627 | [
"DDInter1675",
"DDInter284"
] | Simvastatin | Cannabidiol | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
467,
24,
1627
]
],
[
[
467,
24,
723
],
[
723,
23,
1627
]
],
[
[
467,
25,
760
],
[
760,
62,
1627
]
],
[
[
467,
25,
609
],
[
609,
... | [
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[... | Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a minor interaction that can limit clinical effects when taken with Cannabidiol
Simvastatin may lead to a major life threatening interaction when taken with Cobicistat and Cobicistat may cause... |
DB01037 | DB01124 | 1,161 | 1,411 | [
"DDInter1653",
"DDInter1828"
] | Selegiline | Tolbutamide | A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual... | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
1161,
24,
1411
]
],
[
[
1161,
24,
959
],
[
959,
40,
1411
]
],
[
[
1161,
63,
245
],
[
245,
40,
1411
]
],
[
[
1161,
6,
10215
],
[
10215,... | [
[
[
"Selegiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Selegiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Selegiline may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Selegiline may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Tolbutamide (Compound... |
DB11793 | DB12015 | 738 | 1,033 | [
"DDInter1297",
"DDInter53"
] | Niraparib | Alpelisib | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
738,
24,
1033
]
],
[
[
738,
64,
1510
],
[
1510,
24,
1033
]
],
[
[
738,
63,
322
],
[
322,
24,
1033
]
],
[
[
738,
24,
1612
],
[
1612,
... | [
[
[
"Niraparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Niraparib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
],
[
"Teriflunom... | Niraparib may lead to a major life threatening interaction when taken with Teriflunomide and Teriflunomide may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may cau... |
DB01229 | DB10795 | 973 | 221 | [
"DDInter1377",
"DDInter1486"
] | Paclitaxel | Poliovirus type 1 antigen (formaldehyde inactivated) | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
973,
24,
221
]
],
[
[
973,
24,
36
],
[
36,
24,
221
]
],
[
[
973,
64,
581
],
[
581,
24,
221
]
],
[
[
973,
63,
599
],
[
599,
24,
... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken wit... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Eribulin and Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Paclitaxel may lead to a major life threatening interaction when taken wit... |
DB00041 | DB01181 | 1,648 | 1,532 | [
"DDInter38",
"DDInter906"
] | Aldesleukin | Ifosfamide | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
1648,
24,
1532
]
],
[
[
1648,
23,
1299
],
[
1299,
23,
1532
]
],
[
[
1648,
23,
945
],
[
945,
62,
1532
]
],
[
[
1648,
24,
684
],
[
684,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Aldesleukin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Trovafloxacin"
],
[... | Aldesleukin may cause a minor interaction that can limit clinical effects when taken with Trovafloxacin and Trovafloxacin may cause a minor interaction that can limit clinical effects when taken with Ifosfamide
Aldesleukin may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin and Sp... |
DB00397 | DB00831 | 1,466 | 1,178 | [
"DDInter1458",
"DDInter1866"
] | Phenylpropanolamine | Trifluoperazine | Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Moderate | 1 | [
[
[
1466,
24,
1178
]
],
[
[
1466,
24,
9
],
[
9,
1,
1178
]
],
[
[
1466,
24,
216
],
[
216,
40,
1178
]
],
[
[
1466,
6,
5214
],
[
5214,
... | [
[
[
"Phenylpropanolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
]
],
[
[
"Phenylpropanolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meth... | Phenylpropanolamine may cause a moderate interaction that could exacerbate diseases when taken with Methotrimeprazine and Methotrimeprazine (Compound) resembles Trifluoperazine (Compound)
Phenylpropanolamine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpromazine and Chlorpromazin... |
DB01044 | DB01254 | 246 | 1,213 | [
"DDInter809",
"DDInter484"
] | Gatifloxacin | Dasatinib | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Major | 2 | [
[
[
246,
25,
1213
]
],
[
[
246,
7,
6855
],
[
6855,
46,
1213
]
],
[
[
246,
18,
2874
],
[
2874,
46,
1213
]
],
[
[
246,
18,
4729
],
[
4729,
... | [
[
[
"Gatifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
]
],
[
[
"Gatifloxacin",
"{u} (Compound) upregulates {v} (Gene)",
"HLA-DRA"
],
[
"HLA-DRA",
"{u} (Gene) is upregulated by {v} (Compound)... | Gatifloxacin (Compound) upregulates HLA-DRA (Gene) and HLA-DRA (Gene) is upregulated by Dasatinib (Compound)
Gatifloxacin (Compound) downregulates CTSL (Gene) and CTSL (Gene) is upregulated by Dasatinib (Compound)
Gatifloxacin (Compound) downregulates EBNA1BP2 (Gene) and EBNA1BP2 (Gene) is downregulated by Dasatinib (C... |
DB01208 | DB14568 | 945 | 982 | [
"DDInter1705",
"DDInter1000"
] | Sparfloxacin | Ivosidenib | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
945,
25,
982
]
],
[
[
945,
62,
112
],
[
112,
23,
982
]
],
[
[
945,
63,
543
],
[
543,
24,
982
]
],
[
[
945,
24,
28
],
[
28,
24,
... | [
[
[
"Sparfloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Sparfloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metro... | Sparfloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Sparfloxacin may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and ... |
DB01044 | DB14491 | 246 | 428 | [
"DDInter809",
"DDInter725"
] | Gatifloxacin | Ferrous fumarate | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Used in treatment of iron deficiency anemia. | Moderate | 1 | [
[
[
246,
24,
428
]
],
[
[
246,
63,
1096
],
[
1096,
23,
428
]
],
[
[
246,
24,
1193
],
[
1193,
23,
428
]
],
[
[
246,
1,
872
],
[
872,
... | [
[
[
"Gatifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous fumarate"
]
],
[
[
"Gatifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolic acid... | Gatifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid and Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Ferrous fumarate
Gatifloxacin may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00563 | DB00754 | 663 | 157 | [
"DDInter1174",
"DDInter696"
] | Methotrexate | Ethotoin | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to ... | Moderate | 1 | [
[
[
663,
24,
157
]
],
[
[
663,
18,
7248
],
[
7248,
46,
157
]
],
[
[
663,
18,
6351
],
[
6351,
57,
157
]
],
[
[
663,
21,
28763
],
[
28763,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ethotoin"
]
],
[
[
"Methotrexate",
"{u} (Compound) downregulates {v} (Gene)",
"RPP38"
],
[
"RPP38",
"{u} (Gene) is upregulated by {v... | Methotrexate (Compound) downregulates RPP38 (Gene) and RPP38 (Gene) is upregulated by Ethotoin (Compound)
Methotrexate (Compound) downregulates COTL1 (Gene) and COTL1 (Gene) is downregulated by Ethotoin (Compound)
Methotrexate (Compound) causes Chest pain (Side Effect) and Chest pain (Side Effect) is caused by Ethotoin... |
DB01227 | DB01269 | 1,301 | 38 | [
"DDInter1043",
"DDInter1386"
] | Levacetylmethadol | Panitumumab | Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well... | Panitumumab (ABX-EGF) is a recombinant human IgG2 monoclonal antibody that binds specifically to the human epidermal growth factor receptor (EGFR). This drug is an antineoplastic agent. Panitumumab was granted FDA approval on 27 September 2006. | Major | 2 | [
[
[
1301,
25,
38
]
],
[
[
1301,
25,
384
],
[
384,
63,
38
]
],
[
[
1301,
64,
1555
],
[
1555,
24,
38
]
],
[
[
1301,
40,
494
],
[
494,
... | [
[
[
"Levacetylmethadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panitumumab"
]
],
[
[
"Levacetylmethadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idelalisib"
],
[
"Idelalisib... | Levacetylmethadol may lead to a major life threatening interaction when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Panitumumab
Levacetylmethadol may lead to a major life threatening interaction when taken with Oxaliplatin and Oxaliplatin may caus... |
DB00584 | DB06792 | 610 | 1,606 | [
"DDInter638",
"DDInter1023"
] | Enalapril | Lanthanum carbonate | Enalapril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor drug class that works on the renin-angiotensin-aldosterone system, which is responsible for the regulation of blood pressure and fluid and electrolyte homeostasis. Enalapril is an orally-active and long-acting nonsulphydryl antihypert... | Lanthanum carbonate is a phosphate binder commonly used in clinical practice. It is marketed under the trade name _Fosrenol_ by Shire Pharmaceuticals. It is the largest of all pills filled in community pharmacies. Sometimes patients forget that Fosrenol is not swallowed whole, but instead should be chewed. This has led... | Moderate | 1 | [
[
[
610,
24,
1606
]
],
[
[
610,
1,
664
],
[
664,
24,
1606
]
],
[
[
610,
40,
743
],
[
743,
24,
1606
]
],
[
[
610,
1,
664
],
[
664,
40... | [
[
[
"Enalapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lanthanum carbonate"
]
],
[
[
"Enalapril",
"{u} (Compound) resembles {v} (Compound)",
"Perindopril"
],
[
"Perindopril",
"{u} may cause ... | Enalapril (Compound) resembles Perindopril (Compound) and Perindopril may cause a moderate interaction that could exacerbate diseases when taken with Lanthanum carbonate
Enalapril (Compound) resembles Lisinopril (Compound) and Lisinopril may cause a moderate interaction that could exacerbate diseases when taken with La... |
DB00198 | DB00682 | 856 | 126 | [
"DDInter1350",
"DDInter1951"
] | Oseltamivir | Warfarin | Oseltamivir (marketed as the product TamifluⓇ), is an antiviral neuraminidase inhibitor used for the treatment and prophylaxis of infection with influenza viruses A (including pandemic H1N1) and B. Oseltamivir exerts its antiviral activity by inhibiting the activity of the viral neuraminidase enzyme found on the surfac... | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Minor | 0 | [
[
[
856,
23,
126
]
],
[
[
856,
24,
663
],
[
663,
23,
126
]
],
[
[
856,
6,
9320
],
[
9320,
45,
804
],
[
804,
64,
126
]
],
[
[
856,
24... | [
[
[
"Oseltamivir",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Warfarin"
]
],
[
[
"Oseltamivir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
],
[
... | Oseltamivir may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a minor interaction that can limit clinical effects when taken with Warfarin
Oseltamivir (Compound) binds ABCC4 (Gene) and ABCC4 (Gene) is bound by Sulfinpyrazone (Compound) and Sulfinpyra... |
DB00792 | DB01186 | 832 | 107 | [
"DDInter1878",
"DDInter1430"
] | Tripelennamine | Pergolide | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Pergolide is a long-acting dopamine agonist approved in 1982 for the treatment of Parkinson’s Disease. It is an ergot derivative that acts on the dopamine D2 and D3, alpha2- and alpha1-adrenergic, and 5-hydroxytryptamine (5-HT) receptors. It was indicated as adjunct therapy with levodopa/carbidopa in the symptomatic tr... | Moderate | 1 | [
[
[
832,
24,
107
]
],
[
[
832,
6,
12523
],
[
12523,
45,
107
]
],
[
[
832,
63,
1594
],
[
1594,
24,
107
]
],
[
[
832,
24,
100
],
[
100,
... | [
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pergolide"
]
],
[
[
"Tripelennamine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Comp... | Tripelennamine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Pergolide (Compound)
Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Pergolide
Tripelennami... |
DB00039 | DB01073 | 1,253 | 1,488 | [
"DDInter1380",
"DDInter745"
] | Palifermin | Fludarabine | Palifermin is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli. Palifermin was granted FDA approval on 15 December 2004. | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Moderate | 1 | [
[
[
1253,
24,
1488
]
],
[
[
1253,
24,
1426
],
[
1426,
1,
1488
]
],
[
[
1253,
24,
975
],
[
975,
63,
1488
]
],
[
[
1253,
24,
134
],
[
134,
... | [
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
]
],
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azacitidine"
],
[
... | Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Azacitidine and Azacitidine (Compound) resembles Fludarabine (Compound)
Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin and Lurbinectedin may cause a moderate interaction t... |
DB00398 | DB00502 | 79 | 1,300 | [
"DDInter1702",
"DDInter853"
] | Sorafenib | Haloperidol | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Major | 2 | [
[
[
79,
25,
1300
]
],
[
[
79,
25,
78
],
[
78,
1,
1300
]
],
[
[
79,
24,
543
],
[
543,
63,
1300
]
],
[
[
79,
6,
6017
],
[
6017,
45,
... | [
[
[
"Sorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Haloperidol"
]
],
[
[
"Sorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Droperidol"
],
[
"Droperidol",
"{u} (C... | Sorafenib may lead to a major life threatening interaction when taken with Droperidol and Droperidol (Compound) resembles Haloperidol (Compound)
Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Loperamide may cause a moderate interaction that could exacerbate dise... |
DB00889 | DB01254 | 1,133 | 1,213 | [
"DDInter840",
"DDInter484"
] | Granisetron | Dasatinib | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
1133,
24,
1213
]
],
[
[
1133,
6,
8374
],
[
8374,
45,
1213
]
],
[
[
1133,
7,
16300
],
[
16300,
46,
1213
]
],
[
[
1133,
18,
4729
],
[
47... | [
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Granisetron",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Granisetron (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dasatinib (Compound)
Granisetron (Compound) upregulates SLC27A3 (Gene) and SLC27A3 (Gene) is upregulated by Dasatinib (Compound)
Granisetron (Compound) downregulates EBNA1BP2 (Gene) and EBNA1BP2 (Gene) is downregulated by Dasatinib (Compound)
Gran... |
DB00486 | DB00960 | 1,614 | 887 | [
"DDInter1253",
"DDInter1471"
] | Nabilone | Pindolol | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the earl... | Moderate | 1 | [
[
[
1614,
24,
887
]
],
[
[
1614,
24,
819
],
[
819,
40,
887
]
],
[
[
1614,
63,
88
],
[
88,
40,
887
]
],
[
[
1614,
24,
1121
],
[
1121,
... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pindolol"
]
],
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acebutolol"
],
[
"A... | Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Acebutolol and Acebutolol (Compound) resembles Pindolol (Compound)
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Metoprolol and Metoprolol (Compound) resembles Pindolol (Compound)
Nabilone... |
DB00370 | DB01259 | 1,251 | 392 | [
"DDInter1230",
"DDInter1024"
] | Mirtazapine | Lapatinib | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
1251,
24,
392
]
],
[
[
1251,
6,
8374
],
[
8374,
45,
392
]
],
[
[
1251,
21,
28688
],
[
28688,
60,
392
]
],
[
[
1251,
23,
112
],
[
112,
... | [
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Mirtazapine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Mirtazapine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lapatinib (Compound)
Mirtazapine (Compound) causes Epistaxis (Side Effect) and Epistaxis (Side Effect) is caused by Lapatinib (Compound)
Mirtazapine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Me... |
DB00283 | DB00312 | 701 | 1,023 | [
"DDInter395",
"DDInter1423"
] | Clemastine | Pentobarbital | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Dr... | Moderate | 1 | [
[
[
701,
24,
1023
]
],
[
[
701,
24,
682
],
[
682,
40,
1023
]
],
[
[
701,
63,
288
],
[
288,
40,
1023
]
],
[
[
701,
6,
8374
],
[
8374,
... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentobarbital"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thiopental"
],
[... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Thiopental and Thiopental (Compound) resembles Pentobarbital (Compound)
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Butalbital and Butalbital (Compound) resembles Pentobarbital (Comp... |
DB00620 | DB00691 | 175 | 1,058 | [
"DDInter1855",
"DDInter1237"
] | Triamcinolone | Moexipril | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney prob... | Moderate | 1 | [
[
[
175,
24,
1058
]
],
[
[
175,
63,
1638
],
[
1638,
1,
1058
]
],
[
[
175,
24,
743
],
[
743,
1,
1058
]
],
[
[
175,
24,
954
],
[
954,
... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Moexipril"
]
],
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trandolapril"
],
... | Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril and Trandolapril (Compound) resembles Moexipril (Compound)
Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Lisinopril and Lisinopril (Compound) resembles Moexipril (Co... |
DB00356 | DB00704 | 1,315 | 267 | [
"DDInter366",
"DDInter1263"
] | Chlorzoxazone | Naltrexone | A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202) | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Moderate | 1 | [
[
[
1315,
24,
267
]
],
[
[
1315,
64,
475
],
[
475,
25,
267
]
],
[
[
1315,
21,
28787
],
[
28787,
60,
267
]
],
[
[
1315,
24,
850
],
[
850,
... | [
[
[
"Chlorzoxazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
]
],
[
[
"Chlorzoxazone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Morphine"
],
[
"Morphi... | Chlorzoxazone may lead to a major life threatening interaction when taken with Morphine and Morphine may lead to a major life threatening interaction when taken with Naltrexone
Chlorzoxazone (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Naltrexone (Compound)
Chlorzoxazone may caus... |
DB00342 | DB00557 | 1,181 | 252 | [
"DDInter1770",
"DDInter895"
] | Terfenadine | Hydroxyzine | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | Moderate | 1 | [
[
[
1181,
24,
252
]
],
[
[
1181,
25,
851
],
[
851,
1,
252
]
],
[
[
1181,
24,
1630
],
[
1630,
1,
252
]
],
[
[
1181,
24,
623
],
[
623,
... | [
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyzine"
]
],
[
[
"Terfenadine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nefazodone"
],
[
"Nefazod... | Terfenadine may lead to a major life threatening interaction when taken with Nefazodone and Nefazodone (Compound) resembles Hydroxyzine (Compound)
Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Perphenazine and Perphenazine (Compound) resembles Hydroxyzine (Compound)
Terfena... |
DB05676 | DB12364 | 1,513 | 1,421 | [
"DDInter111",
"DDInter200"
] | Apremilast | Betrixaban | Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of symptoms resulting from certain inflammatory autoimmune diseases. It belongs to the same drug class as [Roflumilast] and [Crisaborole].[A181244,L7495] Initially approved in 2014, it is marketed by Celgene. In July... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Moderate | 1 | [
[
[
1513,
24,
1421
]
],
[
[
1513,
24,
1017
],
[
1017,
24,
1421
]
],
[
[
1513,
64,
759
],
[
759,
24,
1421
]
],
[
[
1513,
25,
913
],
[
913,
... | [
[
[
"Apremilast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betrixaban"
]
],
[
[
"Apremilast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
],
[
... | Apremilast may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Apremilast may lead to a major life threatening interaction when taken with Primidone and Primidone may cause a ... |
DB00777 | DB09472 | 146 | 1,383 | [
"DDInter1537",
"DDInter1693"
] | Propiomazine | Sodium sulfate | Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Struct... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
146,
24,
1383
]
],
[
[
146,
25,
1311
],
[
1311,
24,
1383
]
],
[
[
146,
40,
1178
],
[
1178,
24,
1383
]
],
[
[
146,
24,
1528
],
[
1528,
... | [
[
[
"Propiomazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Propiomazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Metoclopramide"
],
[
... | Propiomazine may lead to a major life threatening interaction when taken with Metoclopramide and Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Propiomazine (Compound) resembles Trifluoperazine (Compound) and Trifluoperazine may cause a moderate interaction... |
DB00087 | DB00564 | 599 | 1,236 | [
"DDInter41",
"DDInter293"
] | Alemtuzumab | Carbamazepine | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Moderate | 1 | [
[
[
599,
24,
1236
]
],
[
[
599,
24,
1101
],
[
1101,
23,
1236
]
],
[
[
599,
24,
510
],
[
510,
24,
1236
]
],
[
[
599,
24,
250
],
[
250,
... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbamazepine"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Carbamazepine
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Albendazole and Al... |
DB06754 | DB11312 | 707 | 298 | [
"DDInter471",
"DDInter1542"
] | Danaparoid | Protein C | Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans. The active constituents are heparan, dermatan and, and they are isolated from the porcine intestinal mucosa [FDA Label]. Danaparoid possesses a potent antithrombic activity tha... | Protein C is an endogenously occurring plasma protein that plays a key role within the coagulation cascade. Protein C is a zymogen, or enzyme precursor, of a vitamin K-dependent anticoagulant glycoprotein (serine protease) that is synthesized in the liver. It is converted by the thrombin/thrombomodulin-complex on the e... | Moderate | 1 | [
[
[
707,
24,
298
]
],
[
[
707,
24,
321
],
[
321,
63,
298
]
],
[
[
707,
64,
500
],
[
500,
24,
298
]
],
[
[
707,
25,
235
],
[
235,
24,... | [
[
[
"Danaparoid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Protein C"
]
],
[
[
"Danaparoid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Selumetinib"
],
[
... | Danaparoid may cause a moderate interaction that could exacerbate diseases when taken with Selumetinib and Selumetinib may cause a moderate interaction that could exacerbate diseases when taken with Protein C
Danaparoid may lead to a major life threatening interaction when taken with Enoxaparin and Enoxaparin may cause... |
DB06605 | DB12364 | 1,409 | 1,421 | [
"DDInter108",
"DDInter200"
] | Apixaban | Betrixaban | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Major | 2 | [
[
[
1409,
25,
1421
]
],
[
[
1409,
23,
297
],
[
297,
23,
1421
]
],
[
[
1409,
23,
1631
],
[
1631,
62,
1421
]
],
[
[
1409,
63,
1091
],
[
1091... | [
[
[
"Apixaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betrixaban"
]
],
[
[
"Apixaban",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clove",
"{u} ma... | Apixaban may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Betrixaban
Apixaban may cause a minor interaction that can limit clinical effects when taken with Turmeric and Turmeric may cause a minor i... |
DB00888 | DB08880 | 1,001 | 1,510 | [
"DDInter1133",
"DDInter1771"
] | Mechlorethamine | Teriflunomide | A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. The FDA granted marketing approval f... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
1001,
25,
1510
]
],
[
[
1001,
63,
1461
],
[
1461,
23,
1510
]
],
[
[
1001,
24,
221
],
[
221,
63,
1510
]
],
[
[
1001,
24,
1136
],
[
1136... | [
[
[
"Mechlorethamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Mechlorethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Mechlorethamine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Teriflunomide
Mechlorethamine may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus t... |
DB00218 | DB00816 | 1,176 | 1,674 | [
"DDInter1247",
"DDInter1346"
] | Moxifloxacin | Orciprenaline | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Major | 2 | [
[
[
1176,
25,
1674
]
],
[
[
1176,
21,
28921
],
[
28921,
60,
1674
]
],
[
[
1176,
25,
251
],
[
251,
23,
1674
]
],
[
[
1176,
25,
891
],
[
891... | [
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Orciprenaline"
]
],
[
[
"Moxifloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Dizziness"
],
[
"Dizziness",
"{u} (Side Effect) is caused by {v... | Moxifloxacin (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Orciprenaline (Compound)
Moxifloxacin may lead to a major life threatening interaction when taken with Betamethasone and Betamethasone may cause a minor interaction that can limit clinical effects when taken with Orciprenali... |
DB00880 | DB01169 | 359 | 57 | [
"DDInter360",
"DDInter120"
] | Chlorothiazide | Arsenic trioxide | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Major | 2 | [
[
[
359,
25,
57
]
],
[
[
359,
24,
603
],
[
603,
63,
57
]
],
[
[
359,
24,
480
],
[
480,
24,
57
]
],
[
[
359,
63,
355
],
[
355,
24,
... | [
[
[
"Chlorothiazide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
]
],
[
[
"Chlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
],
... | Chlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate and Magnesium citrate may cause a moderate interaction that could exacerbate diseases when taken with Arsenic trioxide
Chlorothiazide may cause a moderate interaction that could exacerbate diseases when take... |
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