drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01299 | DB09085 | 698 | 587 | [
"DDInter1722",
"DDInter1779"
] | Sulfadoxine | Tetracaine | A long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections. | Tetracaine is an ester local anaesthetic currently available in combination with lidocaine as a cream and patch. | Moderate | 1 | [
[
[
698,
24,
587
]
],
[
[
698,
1,
1247
],
[
1247,
24,
587
]
],
[
[
698,
40,
161
],
[
161,
24,
587
]
],
[
[
698,
25,
1455
],
[
1455,
... | [
[
[
"Sulfadoxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracaine"
]
],
[
[
"Sulfadoxine",
"{u} (Compound) resembles {v} (Compound)",
"Sulfamethoxazole"
],
[
"Sulfamethoxazole",
"{u} may c... | Sulfadoxine (Compound) resembles Sulfamethoxazole (Compound) and Sulfamethoxazole may cause a moderate interaction that could exacerbate diseases when taken with Tetracaine
Sulfadoxine (Compound) resembles Sulfadiazine (Compound) and Sulfadiazine may cause a moderate interaction that could exacerbate diseases when take... |
DB01246 | DB09401 | 820 | 928 | [
"DDInter45",
"DDInter988"
] | Alimemazine | Isosorbide | A phenothiazine derivative that is used as an antipruritic. | Isosorbide was previously available in an oral formulation for the reduction of intraocular pressure. It was approved by the FDA in 1980, but has since been discontinued. Currently, isosorbide is an organic nitrate currently available in the [isosorbide mononitrate] and [isosorbide dinitrate] forms, and is used for the... | Moderate | 1 | [
[
[
820,
24,
928
]
],
[
[
820,
63,
401
],
[
401,
24,
928
]
],
[
[
820,
1,
104
],
[
104,
24,
928
]
],
[
[
820,
63,
401
],
[
401,
63,
... | [
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isosorbide"
]
],
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
... | Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Isosorbide
Alimemazine (Compound) resembles Methdilazine (Compound) and Methdilazine may cause a moderate interaction ... |
DB00762 | DB01208 | 613 | 945 | [
"DDInter973",
"DDInter1705"
] | Irinotecan | Sparfloxacin | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Minor | 0 | [
[
[
613,
23,
945
]
],
[
[
613,
23,
739
],
[
739,
1,
945
]
],
[
[
613,
62,
1176
],
[
1176,
1,
945
]
],
[
[
613,
6,
4973
],
[
4973,
45... | [
[
[
"Irinotecan",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sparfloxacin"
]
],
[
[
"Irinotecan",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lomefloxacin"
],
[
... | Irinotecan may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Sparfloxacin (Compound)
Irinotecan may cause a minor interaction that can limit clinical effects when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Sparfloxacin (Co... |
DB08916 | DB11652 | 26 | 1,155 | [
"DDInter32",
"DDInter1891"
] | Afatinib | Tucatinib | Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label]. For oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal grow... | Tucatinib is a kinase inhibitor drug used with [trastuzumab] and [capecitabine] in the treatment of unresectable or metastatic HER-2 positive breast cancer. It was developed by Seattle Genetics and approved by the FDA on April 17, 2020. Tucatinib is a promising new treatment for patients with metastatic breast cancer w... | Moderate | 1 | [
[
[
26,
24,
1155
]
],
[
[
26,
63,
1424
],
[
1424,
24,
1155
]
],
[
[
26,
24,
1613
],
[
1613,
24,
1155
]
],
[
[
26,
24,
466
],
[
466,
... | [
[
[
"Afatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tucatinib"
]
],
[
[
"Afatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinine"
],
[
"Qui... | Afatinib may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinine may cause a moderate interaction that could exacerbate diseases when taken with Tucatinib
Afatinib may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a and Pegint... |
DB00860 | DB13928 | 891 | 1,385 | [
"DDInter1513",
"DDInter1660"
] | Prednisolone | Semaglutide | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. Semaglutide was developed by Novo Nordisk and approved ... | Moderate | 1 | [
[
[
891,
24,
1385
]
],
[
[
891,
40,
1103
],
[
1103,
23,
1385
]
],
[
[
891,
64,
839
],
[
839,
24,
1385
]
],
[
[
891,
24,
637
],
[
637,
... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Semaglutide"
]
],
[
[
"Prednisolone",
"{u} (Compound) resembles {v} (Compound)",
"Amcinonide"
],
[
"Amcinonide",
"{u} may cause a mi... | Prednisolone (Compound) resembles Amcinonide (Compound) and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Semaglutide
Prednisolone may lead to a major life threatening interaction when taken with Grepafloxacin and Grepafloxacin may cause a moderate interaction that could exace... |
DB00059 | DB00519 | 1,560 | 1,638 | [
"DDInter1404",
"DDInter1843"
] | Pegaspargase | Trandolapril | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiote... | Moderate | 1 | [
[
[
1560,
24,
1638
]
],
[
[
1560,
24,
954
],
[
954,
40,
1638
]
],
[
[
1560,
24,
170
],
[
170,
63,
1638
]
],
[
[
1560,
24,
590
],
[
590,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trandolapril"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinapril"
],
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril (Compound) resembles Trandolapril (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may cause a moderate interaction that... |
DB06589 | DB08913 | 1,250 | 1,186 | [
"DDInter1400",
"DDInter1561"
] | Pazopanib | Radium Ra 223 dichloride | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Radium Ra 223 Dichloride is a radiopharmaceutical containing the radioisotope radium-223 that emits short range but high linear energy alpha particles. As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas of high bone turnover as seen in bone metastases. It was first ap... | Moderate | 1 | [
[
[
1250,
24,
1186
]
],
[
[
1250,
21,
28722
],
[
28722,
60,
1186
]
],
[
[
1250,
24,
1491
],
[
1491,
24,
1186
]
],
[
[
1250,
24,
1619
],
[
... | [
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Radium Ra 223 dichloride"
]
],
[
[
"Pazopanib",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) i... | Pazopanib (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Radium Ra 223 dichloride (Compound)
Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin and Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with... |
DB06168 | DB10795 | 1,531 | 221 | [
"DDInter281",
"DDInter1486"
] | Canakinumab | Poliovirus type 1 antigen (formaldehyde inactivated) | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
1531,
24,
221
]
],
[
[
1531,
24,
36
],
[
36,
24,
221
]
],
[
[
1531,
64,
581
],
[
581,
24,
221
]
],
[
[
1531,
63,
599
],
[
599,
2... | [
[
[
"Canakinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Canakinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken w... | Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Eribulin and Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Canakinumab may lead to a major life threatening interaction when taken w... |
DB00489 | DB09134 | 17 | 1,552 | [
"DDInter1704",
"DDInter966"
] | Sotalol | Ioversol | Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventric... | Ioversol is a non-ionic compound with a tri-iodinated benzene ring used as a contrast dye in diagnostic procedures to visualize different types of organs and tissues. Iodine has a high atomic density, which gives it the ability to attenuate X-rays. The intravascular administration of iodine compounds, such as ioversol,... | Moderate | 1 | [
[
[
17,
24,
1552
]
],
[
[
17,
1,
88
],
[
88,
24,
1552
]
],
[
[
17,
63,
1648
],
[
1648,
24,
1552
]
],
[
[
17,
24,
278
],
[
278,
63,
... | [
[
[
"Sotalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioversol"
]
],
[
[
"Sotalol",
"{u} (Compound) resembles {v} (Compound)",
"Metoprolol"
],
[
"Metoprolol",
"{u} may cause a moderate intera... | Sotalol (Compound) resembles Metoprolol (Compound) and Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Ioversol
Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exace... |
DB09054 | DB15233 | 384 | 1,650 | [
"DDInter905",
"DDInter142"
] | Idelalisib | Avapritinib | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis.[A189339,L40363] It is one of the first medications available for the trea... | Major | 2 | [
[
[
384,
25,
1650
]
],
[
[
384,
64,
1478
],
[
1478,
24,
1650
]
],
[
[
384,
63,
1374
],
[
1374,
24,
1650
]
],
[
[
384,
25,
159
],
[
159,
... | [
[
[
"Idelalisib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Avapritinib"
]
],
[
[
"Idelalisib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivacaftor"
],
[
"Ivacaftor",
"{u} ma... | Idelalisib may lead to a major life threatening interaction when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Avapritinib
Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone may cause... |
DB00539 | DB01044 | 11 | 246 | [
"DDInter1837",
"DDInter809"
] | Toremifene | Gatifloxacin | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Major | 2 | [
[
[
11,
25,
246
]
],
[
[
11,
25,
739
],
[
739,
1,
246
]
],
[
[
11,
64,
1176
],
[
1176,
1,
246
]
],
[
[
11,
25,
945
],
[
945,
40,
... | [
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gatifloxacin"
]
],
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomefloxacin"
],
[
"Lomefloxacin",
... | Toremifene may lead to a major life threatening interaction when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gatifloxacin (Compound)
Toremifene may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Gatifloxacin (Compound)
Toremifene may lea... |
DB00889 | DB04855 | 1,133 | 540 | [
"DDInter840",
"DDInter602"
] | Granisetron | Dronedarone | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Major | 2 | [
[
[
1133,
25,
540
]
],
[
[
1133,
64,
347
],
[
347,
40,
540
]
],
[
[
1133,
25,
33
],
[
33,
40,
540
]
],
[
[
1133,
6,
8374
],
[
8374,
... | [
[
[
"Granisetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dronedarone"
]
],
[
[
"Granisetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ibutilide"
],
[
"Ibutilide",
"{u} ... | Granisetron may lead to a major life threatening interaction when taken with Ibutilide and Ibutilide (Compound) resembles Dronedarone (Compound)
Granisetron may lead to a major life threatening interaction when taken with Amiodarone and Amiodarone (Compound) resembles Dronedarone (Compound)
Granisetron (Compound) binds... |
DB06282 | DB09293 | 516 | 116 | [
"DDInter1053",
"DDInter954"
] | Levocetirizine | Iodide I-131 | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
516,
24,
116
]
],
[
[
516,
63,
701
],
[
701,
24,
116
]
],
[
[
516,
24,
849
],
[
849,
24,
116
]
],
[
[
516,
24,
337
],
[
337,
63,... | [
[
[
"Levocetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Levocetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
]... | Levocetirizine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Levocetirizine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine ... |
DB00215 | DB06605 | 1,230 | 1,409 | [
"DDInter388",
"DDInter108"
] | Citalopram | Apixaban | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Moderate | 1 | [
[
[
1230,
24,
1409
]
],
[
[
1230,
6,
10215
],
[
10215,
45,
1409
]
],
[
[
1230,
21,
29666
],
[
29666,
60,
1409
]
],
[
[
1230,
25,
1593
],
[
... | [
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apixaban"
]
],
[
[
"Citalopram",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compound)",... | Citalopram (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Apixaban (Compound)
Citalopram (Compound) causes Melaena (Side Effect) and Melaena (Side Effect) is caused by Apixaban (Compound)
Citalopram may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a mo... |
DB00686 | DB06822 | 383 | 802 | [
"DDInter1424",
"DDInter1812"
] | Pentosan polysulfate | Tinzaparin | Pentosan polysulfate is a sulfated pentosyl polysaccharide with heparin-like properties. | Tinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for h... | Moderate | 1 | [
[
[
383,
24,
802
]
],
[
[
383,
24,
1496
],
[
1496,
63,
802
]
],
[
[
383,
63,
1432
],
[
1432,
25,
802
]
],
[
[
383,
24,
1347
],
[
1347,
... | [
[
[
"Pentosan polysulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tinzaparin"
]
],
[
[
"Pentosan polysulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ninteda... | Pentosan polysulfate may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib and Nintedanib may cause a moderate interaction that could exacerbate diseases when taken with Tinzaparin
Pentosan polysulfate may cause a moderate interaction that could exacerbate diseases when taken with A... |
DB06016 | DB06589 | 1,508 | 1,250 | [
"DDInter300",
"DDInter1400"
] | Cariprazine | Pazopanib | Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary. It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT<sub>1A</sub> receptors and as an antagonist at serotonin 5-HT<sub>2A</sub> receptors. Cariprazine has been investigated in... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
1508,
24,
1250
]
],
[
[
1508,
63,
1419
],
[
1419,
24,
1250
]
],
[
[
1508,
24,
214
],
[
214,
63,
1250
]
],
[
[
1508,
24,
761
],
[
761,
... | [
[
[
"Cariprazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Cariprazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
],
[
... | Cariprazine may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Pazopanib
Cariprazine may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostama... |
DB00745 | DB06589 | 307 | 1,250 | [
"DDInter1236",
"DDInter1400"
] | Modafinil | Pazopanib | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Minor | 0 | [
[
[
307,
23,
1250
]
],
[
[
307,
6,
7950
],
[
7950,
45,
1250
]
],
[
[
307,
7,
5266
],
[
5266,
57,
1250
]
],
[
[
307,
21,
29203
],
[
29203,
... | [
[
[
"Modafinil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Pazopanib"
]
],
[
[
"Modafinil",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
... | Modafinil (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Pazopanib (Compound)
Modafinil (Compound) upregulates SMC1A (Gene) and SMC1A (Gene) is downregulated by Pazopanib (Compound)
Modafinil (Compound) causes Aspartate aminotransferase increased (Side Effect) and Aspartate aminotransferase increased (Sid... |
DB00572 | DB01114 | 85 | 272 | [
"DDInter136",
"DDInter362"
] | Atropine | Chlorpheniramine | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Moderate | 1 | [
[
[
85,
24,
272
]
],
[
[
85,
24,
358
],
[
358,
63,
272
]
],
[
[
85,
63,
128
],
[
128,
24,
272
]
],
[
[
85,
21,
28705
],
[
28705,
60,... | [
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
]
],
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orphenadrine"
],
... | Atropine may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Atropine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniram... |
DB00620 | DB01044 | 175 | 246 | [
"DDInter1855",
"DDInter809"
] | Triamcinolone | Gatifloxacin | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Major | 2 | [
[
[
175,
25,
246
]
],
[
[
175,
25,
739
],
[
739,
1,
246
]
],
[
[
175,
64,
1176
],
[
1176,
1,
246
]
],
[
[
175,
25,
945
],
[
945,
40,... | [
[
[
"Triamcinolone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gatifloxacin"
]
],
[
[
"Triamcinolone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomefloxacin"
],
[
"Lomefloxacin",
... | Triamcinolone may lead to a major life threatening interaction when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gatifloxacin (Compound)
Triamcinolone may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Gatifloxacin (Compound)
Triamcinolon... |
DB00688 | DB08895 | 955 | 976 | [
"DDInter1251",
"DDInter1825"
] | Mycophenolate mofetil | Tofacitinib | Mycophenolate mofetil, also known as MMF or CellCept, is a prodrug of mycophenolic acid, and classified as a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). This drug is an immunosuppressant combined with drugs such as [Cyclosporine] and corticosteroids to prevent organ rejection after hepatic, ren... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
955,
25,
976
]
],
[
[
955,
23,
1193
],
[
1193,
62,
976
]
],
[
[
955,
24,
660
],
[
660,
24,
976
]
],
[
[
955,
63,
1215
],
[
1215,
... | [
[
[
"Mycophenolate mofetil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Mycophenolate mofetil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
]... | Mycophenolate mofetil may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Tofacitinib
Mycophenolate mofetil may cause a moderate interaction that could exacerbate diseases when taken... |
DB00092 | DB12332 | 58 | 1,619 | [
"DDInter40",
"DDInter1626"
] | Alefacept | Rucaparib | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
58,
24,
1619
]
],
[
[
58,
24,
259
],
[
259,
24,
1619
]
],
[
[
58,
24,
151
],
[
151,
63,
1619
]
],
[
[
58,
63,
599
],
[
599,
24,
... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
],
[
... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/Cali... |
DB01221 | DB11186 | 1,190 | 1,609 | [
"DDInter1007",
"DDInter1427"
] | Ketamine | Pentoxyverine | Ketamine is an NMDA receptor antagonist with a potent anesthetic effect. It was developed in 1963 as a replacement for phencyclidine (PCP) by Calvin Stevens at Parke Davis Laboratories. It started being used for veterinary purposes in Belgium and in 1964 was proven that compared to PCP, it produced minor hallucinogenic... | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
1190,
24,
1609
]
],
[
[
1190,
63,
104
],
[
104,
24,
1609
]
],
[
[
1190,
24,
649
],
[
649,
24,
1609
]
],
[
[
1190,
63,
1053
],
[
1053,
... | [
[
[
"Ketamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Ketamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
[
... | Ketamine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Ketamine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clo... |
DB01088 | DB01175 | 714 | 318 | [
"DDInter908",
"DDInter672"
] | Iloprost | Escitalopram | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Moderate | 1 | [
[
[
714,
24,
318
]
],
[
[
714,
63,
1230
],
[
1230,
1,
318
]
],
[
[
714,
64,
834
],
[
834,
24,
318
]
],
[
[
714,
63,
1432
],
[
1432,
... | [
[
[
"Iloprost",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Escitalopram"
]
],
[
[
"Iloprost",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Citalopram"
],
[
... | Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Citalopram and Citalopram (Compound) resembles Escitalopram (Compound)
Iloprost may lead to a major life threatening interaction when taken with Drotrecogin alfa and Drotrecogin alfa may cause a moderate interaction that could exac... |
DB01224 | DB08882 | 623 | 1,281 | [
"DDInter1553",
"DDInter1070"
] | Quetiapine | Linagliptin | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
623,
24,
1281
]
],
[
[
623,
24,
1002
],
[
1002,
1,
1281
]
],
[
[
623,
6,
8374
],
[
8374,
45,
1281
]
],
[
[
623,
21,
28966
],
[
28966,
... | [
[
[
"Quetiapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Quetiapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
],
[
... | Quetiapine may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Quetiapine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Linagliptin (Compound)
Quetiapine (Compound) causes Upper respiratory tract infection (... |
DB00773 | DB04855 | 896 | 540 | [
"DDInter702",
"DDInter602"
] | Etoposide | Dronedarone | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Moderate | 1 | [
[
[
896,
24,
540
]
],
[
[
896,
24,
33
],
[
33,
40,
540
]
],
[
[
896,
6,
8374
],
[
8374,
45,
540
]
],
[
[
896,
21,
28883
],
[
28883,
... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronedarone"
]
],
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiodarone"
],
[
... | Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Amiodarone and Amiodarone (Compound) resembles Dronedarone (Compound)
Etoposide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dronedarone (Compound)
Etoposide (Compound) causes Skin disorder (Side Effect) and Skin d... |
DB11730 | DB14575 | 351 | 733 | [
"DDInter1588",
"DDInter674"
] | Ribociclib | Eslicarbazepine | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Eslicarbazepine is an anti-epileptic medication available commercially as [eslicarbazepine acetate]. | Moderate | 1 | [
[
[
351,
24,
733
]
],
[
[
351,
63,
1101
],
[
1101,
23,
733
]
],
[
[
351,
64,
1264
],
[
1264,
24,
733
]
],
[
[
351,
62,
222
],
[
222,
... | [
[
[
"Ribociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eslicarbazepine"
]
],
[
[
"Ribociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
... | Ribociclib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Eslicarbazepine
Ribociclib may lead to a major life threatening interaction when taken with Doxepin and Doxepin may cause a m... |
DB00197 | DB01357 | 1,324 | 890 | [
"DDInter1881",
"DDInter1160"
] | Troglitazone | Mestranol | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | The 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives. | Moderate | 1 | [
[
[
1324,
24,
890
]
],
[
[
1324,
24,
1197
],
[
1197,
40,
890
]
],
[
[
1324,
24,
506
],
[
506,
1,
890
]
],
[
[
1324,
24,
1130
],
[
1130,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mestranol"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norethisterone"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Norethisterone and Norethisterone (Compound) resembles Mestranol (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan and Dextromethorphan (Compound) resembles... |
DB00736 | DB01125 | 660 | 279 | [
"DDInter676",
"DDInter98"
] | Esomeprazole | Anisindione | Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory... | Anisindione is a synthetic anticoagulant and an indanedione derivative. Its anticoagulant action is mediated through the inhibition of the vitamin K-mediated gamma-carboxylation of precursor proteins that are critical in forming the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagu... | Moderate | 1 | [
[
[
660,
24,
279
]
],
[
[
660,
63,
467
],
[
467,
23,
279
]
],
[
[
660,
24,
913
],
[
913,
63,
279
]
],
[
[
660,
64,
1195
],
[
1195,
2... | [
[
[
"Esomeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anisindione"
]
],
[
[
"Esomeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Simvastatin"
],
... | Esomeprazole may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvastatin may cause a minor interaction that can limit clinical effects when taken with Anisindione
Esomeprazole may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide and ... |
DB06810 | DB08880 | 397 | 1,510 | [
"DDInter1484",
"DDInter1771"
] | Plicamycin | Teriflunomide | Plicamycin is an antineoplastic antibiotic produced by Streptomyces plicatus. It has been used in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of hypercalcemia. The manufacturer discontinued plicamycin in 2000. | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
397,
25,
1510
]
],
[
[
397,
63,
1461
],
[
1461,
23,
1510
]
],
[
[
397,
24,
221
],
[
221,
63,
1510
]
],
[
[
397,
63,
1136
],
[
1136,
... | [
[
[
"Plicamycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Plicamycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin ... | Plicamycin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Teriflunomide
Plicamycin may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 anti... |
DB00582 | DB00907 | 1,622 | 290 | [
"DDInter1946",
"DDInter427"
] | Voriconazole | Cocaine (topical) | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts. | Moderate | 1 | [
[
[
1622,
24,
290
]
],
[
[
1622,
6,
21998
],
[
21998,
45,
290
]
],
[
[
1622,
21,
28741
],
[
28741,
60,
290
]
],
[
[
1622,
25,
629
],
[
629... | [
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cocaine"
]
],
[
[
"Voriconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A7-CYP3A51P"
],
[
"CYP3A7-CYP3A51P",
"{u} (Gene) is bound ... | Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Cocaine
Voriconazole (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Cocaine (Compound)
Voriconazole (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Cocaine (Com... |
DB00029 | DB08816 | 25 | 578 | [
"DDInter99",
"DDInter1802"
] | Anistreplase | Ticagrelor | Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl gro... | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
25,
24,
578
]
],
[
[
25,
23,
297
],
[
297,
62,
578
]
],
[
[
25,
24,
191
],
[
191,
23,
578
]
],
[
[
25,
64,
1578
],
[
1578,
24,
... | [
[
[
"Anistreplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Anistreplase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
... | Anistreplase may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Ticagrelor
Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Aminocaproic acid and Aminocapr... |
DB01250 | DB01362 | 712 | 497 | [
"DDInter1334",
"DDInter960"
] | Olsalazine | Iohexol | Olsalazine is an aminosalicylate and a prodrug of [mesalamine] (5-aminosalicylic acid, 5-ASA). It was first developed for delivering mesalamine to the colon without the use of [sulfapyridine]. Olsalazine comprises two mesalamine molecules joined by an azo bridge, which is cleaved in the colon. Olsalazine is an anti-inf... | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
712,
25,
497
]
],
[
[
712,
64,
258
],
[
258,
40,
497
]
],
[
[
712,
24,
242
],
[
242,
63,
497
]
],
[
[
712,
63,
1416
],
[
1416,
2... | [
[
[
"Olsalazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Olsalazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iodixanol"
],
[
"Iodixanol",
"{u} (Compo... | Olsalazine may lead to a major life threatening interaction when taken with Iodixanol and Iodixanol (Compound) resembles Iohexol (Compound)
Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir and Remdesivir may cause a moderate interaction that could exacerbate diseases... |
DB11071 | DB11095 | 1,004 | 235 | [
"DDInter1449",
"DDInter505"
] | Phenyl salicylate | Desirudin | Phenyl salicylate is a 2-hydroxybenzoic acid phenyl ester. It is utilized in some manufacturing processes of polymers, lacquers, adhesives, waxes, as well as polishes. It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing salicylate (found in ). Phenyl salicylate ma... | Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three dis... | Moderate | 1 | [
[
[
1004,
24,
235
]
],
[
[
1004,
63,
578
],
[
578,
24,
235
]
],
[
[
1004,
63,
1409
],
[
1409,
25,
235
]
],
[
[
1004,
24,
1421
],
[
1421,
... | [
[
[
"Phenyl salicylate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desirudin"
]
],
[
[
"Phenyl salicylate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
... | Phenyl salicylate may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Desirudin
Phenyl salicylate may cause a moderate interaction that could exacerbate diseases when taken with Apixaban... |
DB01058 | DB09048 | 978 | 555 | [
"DDInter1510",
"DDInter1284"
] | Praziquantel | Netupitant | Praziquantel is a pyrazino-isoquinolein derivative from the thioxantonic group used as a broad anthelmintic spectrum. Specifically, it is known as a treatment of trematodes and cestodes infections such as schistosomiasis, taeniasis, and cysticercosis. The efficacy of praziquantel in treating parasitic flatworms infecti... | Netupitant is an antiemitic drug approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy. Netupitant is a neurokinin 1 receptor antagonist. The combination drug i... | Moderate | 1 | [
[
[
978,
24,
555
]
],
[
[
978,
63,
1101
],
[
1101,
23,
555
]
],
[
[
978,
24,
283
],
[
283,
62,
555
]
],
[
[
978,
63,
1324
],
[
1324,
... | [
[
[
"Praziquantel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Netupitant"
]
],
[
[
"Praziquantel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
... | Praziquantel may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Netupitant
Praziquantel may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedr... |
DB00726 | DB13074 | 1,164 | 877 | [
"DDInter1876",
"DDInter1110"
] | Trimipramine | Macimorelin | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Major | 2 | [
[
[
1164,
25,
877
]
],
[
[
1164,
23,
112
],
[
112,
23,
877
]
],
[
[
1164,
63,
85
],
[
85,
24,
877
]
],
[
[
1164,
24,
913
],
[
913,
2... | [
[
[
"Trimipramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Macimorelin"
]
],
[
[
"Trimipramine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metr... | Trimipramine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Atropine and A... |
DB00738 | DB01218 | 485 | 1,493 | [
"DDInter1420",
"DDInter852"
] | Pentamidine | Halofantrine | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Major | 2 | [
[
[
485,
25,
1493
]
],
[
[
485,
6,
3486
],
[
3486,
45,
1493
]
],
[
[
485,
21,
28810
],
[
28810,
60,
1493
]
],
[
[
485,
24,
479
],
[
479,
... | [
[
[
"Pentamidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Halofantrine"
]
],
[
[
"Pentamidine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",
"Hal... | Pentamidine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Halofantrine (Compound)
Pentamidine (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Halofantrine (Compound)
Pentamidine may cause a moderate interaction that could exacerbate diseases when... |
DB01234 | DB06448 | 1,220 | 171 | [
"DDInter513",
"DDInter1087"
] | Dexamethasone | Lonafarnib | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Major | 2 | [
[
[
1220,
25,
171
]
],
[
[
1220,
63,
254
],
[
254,
24,
171
]
],
[
[
1220,
1,
1351
],
[
1351,
24,
171
]
],
[
[
1220,
62,
608
],
[
608,
... | [
[
[
"Dexamethasone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lonafarnib"
]
],
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nitisinone"
],
[
"Niti... | Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Nitisinone and Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Lonafarnib
Dexamethasone (Compound) resembles Flunisolide (Compound) and Flunisolide may cause a moderate interaction th... |
DB01217 | DB09381 | 630 | 192 | [
"DDInter95",
"DDInter678"
] | Anastrozole | Esterified estrogens | Anastrozole is a non-steroidal aromatase inhibitor (AI), similar to [letrozole], used to decrease circulating estrogen levels in the treatment of postmenopausal women with estrogen-responsive breast cancer. Anastrozole is also related to [exemestane], a steroidal AI, but its non-steroidal nature provides stark advantag... | Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of me... | Moderate | 1 | [
[
[
630,
24,
192
]
],
[
[
630,
24,
214
],
[
214,
63,
192
]
],
[
[
630,
64,
770
],
[
770,
25,
192
]
],
[
[
630,
24,
214
],
[
214,
63,... | [
[
[
"Anastrozole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esterified estrogens"
]
],
[
[
"Anastrozole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
... | Anastrozole may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Esterified estrogens
Anastrozole may lead to a major life threatening interaction when taken with Thalidomide and Thal... |
DB00446 | DB11979 | 597 | 1,320 | [
"DDInter351",
"DDInter625"
] | Chloramphenicol | Elagolix | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
597,
24,
1320
]
],
[
[
597,
63,
168
],
[
168,
23,
1320
]
],
[
[
597,
23,
271
],
[
271,
23,
1320
]
],
[
[
597,
24,
1297
],
[
1297,
... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Elagolix
Chloramphenicol may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mi... |
DB00679 | DB01619 | 684 | 830 | [
"DDInter1796",
"DDInter1441"
] | Thioridazine | Phenindamine | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Moderate | 1 | [
[
[
684,
24,
830
]
],
[
[
684,
1,
11321
],
[
11321,
40,
830
]
],
[
[
684,
24,
537
],
[
537,
40,
830
]
],
[
[
684,
63,
13
],
[
13,
24... | [
[
[
"Thioridazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
]
],
[
[
"Thioridazine",
"{u} (Compound) resembles {v} (Compound)",
"Metixene"
],
[
"Metixene",
"{u} (Compound) resemb... | Thioridazine (Compound) resembles Metixene (Compound) and Metixene (Compound) resembles Phenindamine (Compound)
Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) resembles Phenindamine (Compound)
Thioridazine may cause a moderate interaction ... |
DB01069 | DB01169 | 401 | 57 | [
"DDInter1533",
"DDInter120"
] | Promethazine | Arsenic trioxide | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Major | 2 | [
[
[
401,
25,
57
]
],
[
[
401,
6,
4973
],
[
4973,
45,
57
]
],
[
[
401,
62,
1247
],
[
1247,
23,
57
]
],
[
[
401,
63,
480
],
[
480,
24,... | [
[
[
"Promethazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
]
],
[
[
"Promethazine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Promethazine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Arsenic trioxide (Compound)
Promethazine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Arsenic triox... |
DB00835 | DB00899 | 100 | 411 | [
"DDInter245",
"DDInter1579"
] | Brompheniramine | Remifentanil | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Remifentanil (marketed by Abbott as Ultiva) is a potent ultra short-acting synthetic opioid given to patients during surgery for pain relief and adjunctive to an anaesthetic. Remifentanil is a specific mu-type-opioid receptor agonist which means it reduces sympathetic nervous system tone, and causes respiratory depress... | Moderate | 1 | [
[
[
100,
24,
411
]
],
[
[
100,
63,
1322
],
[
1322,
40,
411
]
],
[
[
100,
63,
704
],
[
704,
1,
411
]
],
[
[
100,
74,
662
],
[
662,
24... | [
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remifentanil"
]
],
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alfentanil"
... | Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Alfentanil and Alfentanil (Compound) resembles Remifentanil (Compound)
Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl (Compound) resembles Remifentanil (... |
DB00831 | DB06335 | 1,178 | 761 | [
"DDInter1866",
"DDInter1646"
] | Trifluoperazine | Saxagliptin | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
1178,
24,
761
]
],
[
[
1178,
21,
28722
],
[
28722,
60,
761
]
],
[
[
1178,
24,
1491
],
[
1491,
63,
761
]
],
[
[
1178,
35,
104
],
[
104,... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Trifluoperazine",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is... | Trifluoperazine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Saxagliptin (Compound)
Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin and Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB01124 | DB01285 | 1,411 | 708 | [
"DDInter1828",
"DDInter445"
] | Tolbutamide | Corticotropin | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Moderate | 1 | [
[
[
1411,
24,
708
]
],
[
[
1411,
63,
455
],
[
455,
23,
708
]
],
[
[
1411,
24,
659
],
[
659,
62,
708
]
],
[
[
1411,
1,
245
],
[
245,
... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
]
],
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
],
... | Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a minor interaction that can limit clinical effects when taken with Corticotropin
Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vil... |
DB00804 | DB00924 | 1,507 | 1,405 | [
"DDInter543",
"DDInter454"
] | Dicyclomine | Cyclobenzaprine | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | Cyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961 and has been available for human use since 1977. It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from [Amitriptyline] by only a single double bond.[A185039,A184... | Moderate | 1 | [
[
[
1507,
24,
1405
]
],
[
[
1507,
63,
1302
],
[
1302,
1,
1405
]
],
[
[
1507,
24,
358
],
[
358,
1,
1405
]
],
[
[
1507,
24,
401
],
[
401,
... | [
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclobenzaprine"
]
],
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Protriptyline"
]... | Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Protriptyline and Protriptyline (Compound) resembles Cyclobenzaprine (Compound)
Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Orphenadrine (Compound) resembles Cyclo... |
DB00328 | DB09104 | 831 | 286 | [
"DDInter921",
"DDInter1118"
] | Indomethacin | Magnesium hydroxide | Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlor... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Minor | 0 | [
[
[
831,
23,
286
]
],
[
[
831,
23,
752
],
[
752,
23,
286
]
],
[
[
831,
63,
1018
],
[
1018,
23,
286
]
],
[
[
831,
25,
1468
],
[
1468,
... | [
[
[
"Indomethacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Indomethacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cimetidine"
],... | Indomethacin may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Ticlopidine ... |
DB00612 | DB06292 | 1,121 | 549 | [
"DDInter216",
"DDInter474"
] | Bisoprolol | Dapagliflozin | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
1121,
24,
549
]
],
[
[
1121,
24,
1344
],
[
1344,
40,
549
]
],
[
[
1121,
6,
8374
],
[
8374,
45,
549
]
],
[
[
1121,
21,
29222
],
[
29222... | [
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
... | Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Bisoprolol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dapagliflozin (Compound)
Bisoprolol (Compound) causes Hypoglycaemia (Side Effec... |
DB00545 | DB01222 | 751 | 617 | [
"DDInter1548",
"DDInter246"
] | Pyridostigmine | Budesonide | Myasthenia gravis is an autoimmune disease involving dysfunction at the neuromuscular junction, most commonly due to autoantibodies directed against the acetylcholine receptor (AChR), which results in muscle tone loss, muscle weakness, and fatigue. Acetylcholinesterase inhibitors have been the symptomatic treatment of ... | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Moderate | 1 | [
[
[
751,
24,
617
]
],
[
[
751,
63,
251
],
[
251,
1,
617
]
],
[
[
751,
24,
175
],
[
175,
1,
617
]
],
[
[
751,
6,
8374
],
[
8374,
45,
... | [
[
[
"Pyridostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Budesonide"
]
],
[
[
"Pyridostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betamethasone"
... | Pyridostigmine may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone (Compound) resembles Budesonide (Compound)
Pyridostigmine may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Bu... |
DB00986 | DB01085 | 1,192 | 562 | [
"DDInter834",
"DDInter1465"
] | Glycopyrronium | Pilocarpine | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | A naturally occurring alkaloid derived from the _Pilocarpus_ plants, pilocarpine is a muscarinic acetylcholine agonist.[A262016, A262036] Pilocarpine is associated with parasympathomimetic effects by selectively working on muscarinic receptors. Pilocarpine is used to treat dry mouth and various ophthalmic conditions, i... | Moderate | 1 | [
[
[
1192,
24,
562
]
],
[
[
1192,
6,
7992
],
[
7992,
45,
562
]
],
[
[
1192,
21,
28929
],
[
28929,
60,
562
]
],
[
[
1192,
63,
1507
],
[
1507... | [
[
[
"Glycopyrronium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pilocarpine"
]
],
[
[
"Glycopyrronium",
"{u} (Compound) binds {v} (Gene)",
"CHRM1"
],
[
"CHRM1",
"{u} (Gene) is bound by {v} (Comp... | Glycopyrronium (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Pilocarpine (Compound)
Glycopyrronium (Compound) causes Confusional state (Side Effect) and Confusional state (Side Effect) is caused by Pilocarpine (Compound)
Glycopyrronium may cause a moderate interaction that could exacerbate diseases when ta... |
DB00514 | DB00690 | 506 | 1,216 | [
"DDInter527",
"DDInter762"
] | Dextromethorphan | Flurazepam | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | A benzodiazepine derivative used mainly as a hypnotic. | Moderate | 1 | [
[
[
506,
24,
1216
]
],
[
[
506,
24,
1418
],
[
1418,
1,
1216
]
],
[
[
506,
24,
481
],
[
481,
40,
1216
]
],
[
[
506,
63,
216
],
[
216,
... | [
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurazepam"
]
],
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estazolam"
... | Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Estazolam and Estazolam (Compound) resembles Flurazepam (Compound)
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Quazepam and Quazepam (Compound) resembles Flurazepam (Comp... |
DB01162 | DB01234 | 195 | 1,220 | [
"DDInter1767",
"DDInter513"
] | Terazosin | Dexamethasone | Terazosin is a quinazoline derivative alpha-1-selective adrenergic blocking agent indicated for benign prostatic hyperplasia and hypertension[FDA Label]. Terazosin blocks adrenaline's action on alpha-1 adrenergic receptors, causing relaxation of smooth muscle in blood vessels and the prostate. | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
195,
24,
1220
]
],
[
[
195,
63,
870
],
[
870,
1,
1220
]
],
[
[
195,
63,
175
],
[
175,
40,
1220
]
],
[
[
195,
24,
617
],
[
617,
4... | [
[
[
"Terazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Terazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
],
... | Terazosin may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Terazosin may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Dexam... |
DB00010 | DB00047 | 1,649 | 176 | [
"DDInter1661",
"DDInter932"
] | Sermorelin | Insulin glargine | Sermorelin acetate is the acetate salt of an amidated synthetic 29-amino acid peptide (GRF 1-29 NH 2 ) that corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone (GHRH or GRF) consisting of 44 amino acid residues | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Moderate | 1 | [
[
[
1649,
24,
176
]
],
[
[
1649,
24,
135
],
[
135,
63,
176
]
],
[
[
1649,
24,
135
],
[
135,
62,
1103
],
[
1103,
62,
176
]
],
[
[
1649,
... | [
[
[
"Sermorelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glargine"
]
],
[
[
"Sermorelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Albiglutide"
],
... | Sermorelin may cause a moderate interaction that could exacerbate diseases when taken with Albiglutide and Albiglutide may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine
Sermorelin may cause a moderate interaction that could exacerbate diseases when taken with Albiglutide a... |
DB00163 | DB01222 | 1,461 | 617 | [
"DDInter1943",
"DDInter246"
] | Vitamin E | Budesonide | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Minor | 0 | [
[
[
1461,
23,
617
]
],
[
[
1461,
23,
251
],
[
251,
1,
617
]
],
[
[
1461,
24,
578
],
[
578,
63,
617
]
],
[
[
1461,
23,
1531
],
[
1531,
... | [
[
[
"Vitamin E",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Budesonide"
]
],
[
[
"Vitamin E",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Betamethasone"
],
[
... | Vitamin E may cause a minor interaction that can limit clinical effects when taken with Betamethasone and Betamethasone (Compound) resembles Budesonide (Compound)
Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a moderate interaction that cou... |
DB00532 | DB00719 | 208 | 1,219 | [
"DDInter1152",
"DDInter149"
] | Mephenytoin | Azatadine | Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subuni... | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Moderate | 1 | [
[
[
208,
24,
1219
]
],
[
[
208,
63,
13
],
[
13,
24,
1219
]
],
[
[
208,
24,
1376
],
[
1376,
63,
1219
]
],
[
[
208,
24,
717
],
[
717,
... | [
[
[
"Mephenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azatadine"
]
],
[
[
"Mephenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
... | Mephenytoin may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Mephenytoin may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydram... |
DB01265 | DB08870 | 1,477 | 850 | [
"DDInter1757",
"DDInter228"
] | Telbivudine | Brentuximab vedotin | Telbivudine is a synthetic thymidine nucleoside analog with specific activity against the hepatitis B virus. Telbivudine is orally administered, with good tolerance, lack of toxicity and no dose-limiting side effects. | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
1477,
24,
850
]
],
[
[
1477,
63,
896
],
[
896,
24,
850
]
],
[
[
1477,
64,
367
],
[
367,
24,
850
]
],
[
[
1477,
24,
1468
],
[
1468,
... | [
[
[
"Telbivudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Telbivudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
]... | Telbivudine may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Telbivudine may lead to a major life threatening interaction when taken with Interferon alfacon-1 and In... |
DB00095 | DB00163 | 66 | 1,461 | [
"DDInter623",
"DDInter1943"
] | Efalizumab | Vitamin E | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Minor | 0 | [
[
[
66,
23,
1461
]
],
[
[
66,
24,
76
],
[
76,
62,
1461
]
],
[
[
66,
63,
581
],
[
581,
23,
1461
]
],
[
[
66,
25,
1510
],
[
1510,
62,
... | [
[
[
"Efalizumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
]
],
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mogamulizumab"
],
[
... | Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Mogamulizumab and Mogamulizumab may cause a minor interaction that can limit clinical effects when taken with Vitamin E
Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Infliximab and Inf... |
DB00468 | DB06636 | 1,424 | 1,623 | [
"DDInter1557",
"DDInter980"
] | Quinine | Isavuconazonium | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Moderate | 1 | [
[
[
1424,
24,
1623
]
],
[
[
1424,
24,
1419
],
[
1419,
24,
1623
]
],
[
[
1424,
25,
1557
],
[
1557,
24,
1623
]
],
[
[
1424,
63,
1010
],
[
10... | [
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isavuconazonium"
]
],
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
],
[
... | Quinine may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Isavuconazonium
Quinine may lead to a major life threatening interaction when taken with Astemizole and Astemizole may cause a mod... |
DB00222 | DB00331 | 245 | 1,645 | [
"DDInter825",
"DDInter1164"
] | Glimepiride | Metformin | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Moderate | 1 | [
[
[
245,
24,
1645
]
],
[
[
245,
5,
11640
],
[
11640,
44,
1645
]
],
[
[
245,
21,
28714
],
[
28714,
60,
1645
]
],
[
[
245,
62,
333
],
[
333,... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metformin"
]
],
[
[
"Glimepiride",
"{u} (Compound) treats {v} (Disease)",
"type 2 diabetes mellitus"
],
[
"type 2 diabetes mellitus",
... | Glimepiride (Compound) treats type 2 diabetes mellitus (Disease) and type 2 diabetes mellitus (Disease) is treated by Metformin (Compound)
Glimepiride (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Metformin (Compound)
Glimepiride may cause a minor interaction that can limit clinical e... |
DB00188 | DB01138 | 168 | 804 | [
"DDInter222",
"DDInter1726"
] | Bortezomib | Sulfinpyrazone | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties. | Minor | 0 | [
[
[
168,
23,
804
]
],
[
[
168,
23,
998
],
[
998,
1,
804
]
],
[
[
168,
6,
3486
],
[
3486,
45,
804
]
],
[
[
168,
7,
8155
],
[
8155,
45... | [
[
[
"Bortezomib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfinpyrazone"
]
],
[
[
"Bortezomib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Phenylbutazone"
],
... | Bortezomib may cause a minor interaction that can limit clinical effects when taken with Phenylbutazone and Phenylbutazone (Compound) resembles Sulfinpyrazone (Compound)
Bortezomib (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Sulfinpyrazone (Compound)
Bortezomib (Compound) upregulates ABCC5 (Gene) and A... |
DB01159 | DB08868 | 419 | 1,011 | [
"DDInter854",
"DDInter737"
] | Halothane | Fingolimod | A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
419,
25,
1011
]
],
[
[
419,
6,
12523
],
[
12523,
45,
1011
]
],
[
[
419,
62,
112
],
[
112,
23,
1011
]
],
[
[
419,
24,
144
],
[
144,
... | [
[
[
"Halothane",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Halothane",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Fingolimo... | Halothane (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Fingolimod (Compound)
Halothane may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Fingolimod
Halothane may caus... |
DB01227 | DB11730 | 1,301 | 351 | [
"DDInter1043",
"DDInter1588"
] | Levacetylmethadol | Ribociclib | Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
1301,
25,
351
]
],
[
[
1301,
62,
112
],
[
112,
23,
351
]
],
[
[
1301,
63,
222
],
[
222,
23,
351
]
],
[
[
1301,
25,
283
],
[
283,
... | [
[
[
"Levacetylmethadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Levacetylmethadol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Levacetylmethadol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Levacetylmethadol may cause a moderate interaction that could exacerbate diseases when taken with Sibut... |
DB00348 | DB11642 | 254 | 938 | [
"DDInter1300",
"DDInter1480"
] | Nitisinone | Pitolisant | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Moderate | 1 | [
[
[
254,
24,
938
]
],
[
[
254,
24,
760
],
[
760,
24,
938
]
],
[
[
254,
63,
600
],
[
600,
24,
938
]
],
[
[
254,
24,
283
],
[
283,
63,... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitolisant"
]
],
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
],
[
... | Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat and Cobicistat may cause a moderate interaction that could exacerbate diseases when taken with Pitolisant
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluco... |
DB08903 | DB09122 | 996 | 1,613 | [
"DDInter170",
"DDInter1409"
] | Bedaquiline | Peginterferon beta-1a | Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affe... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
996,
24,
1613
]
],
[
[
996,
64,
600
],
[
600,
24,
1613
]
],
[
[
996,
63,
168
],
[
168,
24,
1613
]
],
[
[
996,
25,
1383
],
[
1383,
... | [
[
[
"Bedaquiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Bedaquiline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fluconazole"
],
[
... | Bedaquiline may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Bedaquiline may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortez... |
DB00757 | DB00834 | 1,166 | 932 | [
"DDInter581",
"DDInter1215"
] | Dolasetron | Mifepristone | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Major | 2 | [
[
[
1166,
25,
932
]
],
[
[
1166,
6,
12523
],
[
12523,
45,
932
]
],
[
[
1166,
21,
28762
],
[
28762,
60,
932
]
],
[
[
1166,
23,
112
],
[
112... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mifepristone"
]
],
[
[
"Dolasetron",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Mifep... | Dolasetron (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Mifepristone (Compound)
Dolasetron (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Mifepristone (Compound)
Dolasetron may cause a minor interaction that can limit clinical effects when taken with Metronidazole and M... |
DB00688 | DB08880 | 955 | 1,510 | [
"DDInter1251",
"DDInter1771"
] | Mycophenolate mofetil | Teriflunomide | Mycophenolate mofetil, also known as MMF or CellCept, is a prodrug of mycophenolic acid, and classified as a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). This drug is an immunosuppressant combined with drugs such as [Cyclosporine] and corticosteroids to prevent organ rejection after hepatic, ren... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
955,
25,
1510
]
],
[
[
955,
23,
1193
],
[
1193,
62,
1510
]
],
[
[
955,
64,
303
],
[
303,
24,
1510
]
],
[
[
955,
24,
148
],
[
148,
... | [
[
[
"Mycophenolate mofetil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Mycophenolate mofetil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
... | Mycophenolate mofetil may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Teriflunomide
Mycophenolate mofetil may lead to a major life threatening interaction when taken with Medroxy... |
DB00619 | DB11703 | 1,419 | 405 | [
"DDInter909",
"DDInter9"
] | Imatinib | Acalabrutinib | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Major | 2 | [
[
[
1419,
25,
405
]
],
[
[
1419,
63,
1051
],
[
1051,
24,
405
]
],
[
[
1419,
64,
690
],
[
690,
24,
405
]
],
[
[
1419,
62,
1101
],
[
1101,
... | [
[
[
"Imatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aminoglutethimide"
],
[
"Amin... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Aminoglutethimide and Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Imatinib may lead to a major life threatening interaction when taken with Rifabutin and Rifabutin... |
DB00041 | DB00502 | 1,648 | 1,300 | [
"DDInter38",
"DDInter853"
] | Aldesleukin | Haloperidol | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Moderate | 1 | [
[
[
1648,
24,
1300
]
],
[
[
1648,
24,
78
],
[
78,
1,
1300
]
],
[
[
1648,
24,
1242
],
[
1242,
24,
1300
]
],
[
[
1648,
24,
663
],
[
663,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Haloperidol"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Droperidol"
],
[... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Droperidol and Droperidol (Compound) resembles Haloperidol (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetirizine may cause a moderate interaction that co... |
DB00333 | DB01575 | 576 | 1,054 | [
"DDInter1166",
"DDInter1005"
] | Methadone | Kaolin | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Kaolin is a layered silicate mineral. Kaolin is used in ceramics, medicine, coated paper, as a food additive, in toothpaste, as a light diffusing material in white incandescent light bulbs, and in cosmetics. Until the early 1990s it was the active substance of anti-diarrhoea medicine Kaopectate. | Moderate | 1 | [
[
[
576,
24,
1054
]
],
[
[
576,
24,
407
],
[
407,
63,
1054
]
],
[
[
576,
1,
1301
],
[
1301,
24,
1054
]
],
[
[
576,
24,
85
],
[
85,
2... | [
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Kaolin"
]
],
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
],
[
"Opium"... | Methadone may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause a moderate interaction that could exacerbate diseases when taken with Kaolin
Methadone (Compound) resembles Levacetylmethadol (Compound) and Levacetylmethadol may cause a moderate interaction that could e... |
DB00208 | DB00554 | 1,018 | 1,027 | [
"DDInter1804",
"DDInter1478"
] | Ticlopidine | Piroxicam | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. | Moderate | 1 | [
[
[
1018,
24,
1027
]
],
[
[
1018,
24,
1171
],
[
1171,
1,
1027
]
],
[
[
1018,
6,
6017
],
[
6017,
45,
1027
]
],
[
[
1018,
24,
752
],
[
752,
... | [
[
[
"Ticlopidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Piroxicam"
]
],
[
[
"Ticlopidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meloxicam"
],
[
... | Ticlopidine may cause a moderate interaction that could exacerbate diseases when taken with Meloxicam and Meloxicam (Compound) resembles Piroxicam (Compound)
Ticlopidine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Piroxicam (Compound)
Ticlopidine may cause a moderate interaction that could exacerbate d... |
DB00041 | DB00381 | 1,648 | 376 | [
"DDInter38",
"DDInter79"
] | Aldesleukin | Amlodipine | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial... | Moderate | 1 | [
[
[
1648,
24,
376
]
],
[
[
1648,
24,
1428
],
[
1428,
1,
376
]
],
[
[
1648,
24,
1081
],
[
1081,
40,
376
]
],
[
[
1648,
24,
885
],
[
885,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amlodipine"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isradipine"
],
[
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradipine (Compound) resembles Amlodipine (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Nicardipine and Nicardipine (Compound) resembles Amlodipine (Compou... |
DB00281 | DB09098 | 608 | 98 | [
"DDInter1066",
"DDInter1700"
] | Lidocaine | Somatrem | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anest... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Minor | 0 | [
[
[
608,
23,
98
]
],
[
[
608,
24,
159
],
[
159,
63,
98
]
],
[
[
608,
25,
34
],
[
34,
24,
98
]
],
[
[
608,
23,
690
],
[
690,
24,
... | [
[
[
"Lidocaine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Somatrem"
]
],
[
[
"Lidocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
[
... | Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Somatrem
Lidocaine may lead to a major life threatening interaction when taken with Fosamprenavir and Fosamprenavir ma... |
DB00620 | DB14711 | 175 | 779 | [
"DDInter1855",
"DDInter1680"
] | Triamcinolone | Smallpox (Vaccinia) Vaccine, Live | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | The New York City Board of Health strain of _Vaccinia_ is a viral strain used as a component of some smallpox vaccinations. ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this strain. | Major | 2 | [
[
[
175,
25,
779
]
],
[
[
175,
64,
1064
],
[
1064,
25,
779
]
],
[
[
175,
24,
478
],
[
478,
25,
779
]
],
[
[
175,
25,
1377
],
[
1377,
... | [
[
[
"Triamcinolone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Smallpox (Vaccinia) Vaccine, Live"
]
],
[
[
"Triamcinolone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[
... | Triamcinolone may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Smallpox (Vaccinia) Vaccine, Live
Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotini... |
DB06441 | DB14276 | 936 | 1,631 | [
"DDInter283",
"DDInter1892"
] | Cangrelor | Turmeric | Cangrelor is an intravenous, direct-acting, reversible P2Y12 inhibitor for patients undergoing percutaneous coronary intervention (PCI) who have not been yet treated by oral P2Y12 inhibitors. An advantage Cangrelor provides over oral P2Y12 inhibitors (such as prasugrel, ticagrelor, and clopidogrel) is that it is an act... | Turmeric is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. | Minor | 0 | [
[
[
936,
23,
1631
]
],
[
[
936,
64,
20
],
[
20,
23,
1631
]
],
[
[
936,
25,
1421
],
[
1421,
23,
1631
]
],
[
[
936,
64,
20
],
[
20,
24... | [
[
[
"Cangrelor",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Turmeric"
]
],
[
[
"Cangrelor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tenecteplase"
],
[
"Tenecteplase",... | Cangrelor may lead to a major life threatening interaction when taken with Tenecteplase and Tenecteplase may cause a minor interaction that can limit clinical effects when taken with Turmeric
Cangrelor may lead to a major life threatening interaction when taken with Betrixaban and Betrixaban may cause a minor interacti... |
DB01035 | DB11718 | 1,401 | 927 | [
"DDInter1524",
"DDInter640"
] | Procainamide | Encorafenib | A derivative of procaine with less CNS action. | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Major | 2 | [
[
[
1401,
25,
927
]
],
[
[
1401,
62,
112
],
[
112,
23,
927
]
],
[
[
1401,
24,
720
],
[
720,
24,
927
]
],
[
[
1401,
25,
1491
],
[
1491,
... | [
[
[
"Procainamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
]
],
[
[
"Procainamide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metr... | Procainamide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Encorafenib
Procainamide may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil an... |
DB00455 | DB00582 | 1,601 | 1,622 | [
"DDInter1091",
"DDInter1946"
] | Loratadine | Voriconazole | Loratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis. A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st generation counterparts in many clinical situations. | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Moderate | 1 | [
[
[
1601,
24,
1622
]
],
[
[
1601,
6,
8374
],
[
8374,
45,
1622
]
],
[
[
1601,
21,
28997
],
[
28997,
60,
1622
]
],
[
[
1601,
24,
1419
],
[
1... | [
[
[
"Loratadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Voriconazole"
]
],
[
[
"Loratadine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Loratadine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Voriconazole (Compound)
Loratadine (Compound) causes Ill-defined disorder (Side Effect) and Ill-defined disorder (Side Effect) is caused by Voriconazole (Compound)
Loratadine may cause a moderate interaction that could exacerbate diseases when take... |
DB01238 | DB08868 | 673 | 1,011 | [
"DDInter118",
"DDInter737"
] | Aripiprazole | Fingolimod | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Moderate | 1 | [
[
[
673,
24,
1011
]
],
[
[
673,
6,
12523
],
[
12523,
45,
1011
]
],
[
[
673,
21,
28892
],
[
28892,
60,
1011
]
],
[
[
673,
24,
578
],
[
578,... | [
[
[
"Aripiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fingolimod"
]
],
[
[
"Aripiprazole",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compoun... | Aripiprazole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Fingolimod (Compound)
Aripiprazole (Compound) causes Cardiac arrest (Side Effect) and Cardiac arrest (Side Effect) is caused by Fingolimod (Compound)
Aripiprazole may cause a moderate interaction that could exacerbate diseases when taken with Tic... |
DB00331 | DB01362 | 1,645 | 497 | [
"DDInter1164",
"DDInter960"
] | Metformin | Iohexol | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
1645,
25,
497
]
],
[
[
1645,
25,
258
],
[
258,
40,
497
]
],
[
[
1645,
21,
28787
],
[
28787,
60,
497
]
],
[
[
1645,
24,
323
],
[
323,
... | [
[
[
"Metformin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Metformin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iodixanol"
],
[
"Iodixanol",
"{u} (Compoun... | Metformin may lead to a major life threatening interaction when taken with Iodixanol and Iodixanol (Compound) resembles Iohexol (Compound)
Metformin (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Iohexol (Compound)
Metformin may cause a moderate interaction that could exacerbate di... |
DB01142 | DB06700 | 1,264 | 643 | [
"DDInter593",
"DDInter511"
] | Doxepin | Desvenlafaxine | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of ad... | Major | 2 | [
[
[
1264,
25,
643
]
],
[
[
1264,
64,
1100
],
[
1100,
1,
643
]
],
[
[
1264,
6,
7390
],
[
7390,
45,
643
]
],
[
[
1264,
21,
28641
],
[
28641,... | [
[
[
"Doxepin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Desvenlafaxine"
]
],
[
[
"Doxepin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Venlafaxine"
],
[
"Venlafaxine",
"{u} (... | Doxepin may lead to a major life threatening interaction when taken with Venlafaxine and Venlafaxine (Compound) resembles Desvenlafaxine (Compound)
Doxepin (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Desvenlafaxine (Compound)
Doxepin (Compound) causes Hot flush (Side Effect) and Hot flush (Side Effect)... |
DB00242 | DB01056 | 1,064 | 571 | [
"DDInter392",
"DDInter1823"
] | Cladribine | Tocainide | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | An antiarrhythmic agent which exerts a potential- and frequency-dependent block of sodium channels. | Major | 2 | [
[
[
1064,
25,
571
]
],
[
[
1064,
25,
976
],
[
976,
63,
571
]
],
[
[
1064,
64,
599
],
[
599,
24,
571
]
],
[
[
1064,
25,
1292
],
[
1292,
... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tocainide"
]
],
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
],
[
"Tofacitinib",
"{u} ... | Cladribine may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Tocainide
Cladribine may lead to a major life threatening interaction when taken with Alemtuzumab and Alemtuzumab may cause a moderate i... |
DB00445 | DB13074 | 322 | 877 | [
"DDInter655",
"DDInter1110"
] | Epirubicin | Macimorelin | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Major | 2 | [
[
[
322,
25,
877
]
],
[
[
322,
23,
112
],
[
112,
23,
877
]
],
[
[
322,
24,
99
],
[
99,
24,
877
]
],
[
[
322,
63,
1101
],
[
1101,
24,... | [
[
[
"Epirubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Macimorelin"
]
],
[
[
"Epirubicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronid... | Epirubicin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Propylthiouracil a... |
DB00747 | DB01114 | 1,442 | 272 | [
"DDInter1647",
"DDInter362"
] | Scopolamine | Chlorpheniramine | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Moderate | 1 | [
[
[
1442,
24,
272
]
],
[
[
1442,
24,
358
],
[
358,
63,
272
]
],
[
[
1442,
63,
128
],
[
128,
24,
272
]
],
[
[
1442,
21,
28705
],
[
28705,
... | [
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
]
],
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orphenadrine"
]... | Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Dexbromph... |
DB01185 | DB01285 | 155 | 708 | [
"DDInter759",
"DDInter445"
] | Fluoxymesterone | Corticotropin | An anabolic steroid that has been used in the treatment of male hypogonadism, delayed puberty in males, and in the treatment of breast neoplasms in women. | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Moderate | 1 | [
[
[
155,
24,
708
]
],
[
[
155,
63,
245
],
[
245,
24,
708
]
],
[
[
155,
64,
126
],
[
126,
24,
708
]
],
[
[
155,
1,
312
],
[
312,
24,
... | [
[
[
"Fluoxymesterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
]
],
[
[
"Fluoxymesterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
... | Fluoxymesterone may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin
Fluoxymesterone may lead to a major life threatening interaction when taken with Warfarin and Warfarin... |
DB00193 | DB00792 | 534 | 832 | [
"DDInter1841",
"DDInter1878"
] | Tramadol | Tripelennamine | Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatmen... | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Moderate | 1 | [
[
[
534,
24,
832
]
],
[
[
534,
24,
100
],
[
100,
63,
832
]
],
[
[
534,
25,
1264
],
[
1264,
63,
832
]
],
[
[
534,
24,
649
],
[
649,
1... | [
[
[
"Tramadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
]
],
[
[
"Tramadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
],
... | Tramadol may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine
Tramadol may lead to a major life threatening interaction when taken with Doxepin and Doxepin may ca... |
DB00526 | DB00626 | 1,555 | 1,441 | [
"DDInter1355",
"DDInter161"
] | Oxaliplatin | Bacitracin | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Bacitracin is a combination of at least 9 bacitracins.[A955,A181952] 60-80% of commercially prepared bacitracin is bacitracin A. The bacillus that produces bacitracin was first isolated from a knee scrape in 1945 from the knee wound of a child named Margaret Tracy. Bacitracin was granted FDA approval on 29 July 1948.[A... | Moderate | 1 | [
[
[
1555,
24,
1441
]
],
[
[
1555,
24,
1481
],
[
1481,
1,
1441
]
],
[
[
1555,
24,
1477
],
[
1477,
63,
1441
]
],
[
[
1555,
63,
91
],
[
91,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bacitracin"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polymyxin B"
],
[... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Polymyxin B and Polymyxin B (Compound) resembles Bacitracin (Compound)
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Telbivudine and Telbivudine may cause a moderate interaction that... |
DB01261 | DB06343 | 170 | 1,379 | [
"DDInter1679",
"DDInter1766"
] | Sitagliptin | Teprotumumab | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Teprotumumab is a fully human IgG1 monoclonal antibody directed against the human insulin-like growth factor-1 receptor. Following a clinical trial in which its efficacy in the treatment of thyroid eye disease (TED) was assessed, it received "breakthrough therapy" designation from the FDA in 2016 and was approved by th... | Moderate | 1 | [
[
[
170,
24,
1379
]
],
[
[
170,
24,
1296
],
[
1296,
63,
1379
]
],
[
[
170,
63,
959
],
[
959,
24,
1379
]
],
[
[
170,
24,
1254
],
[
1254,
... | [
[
[
"Sitagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Teprotumumab"
]
],
[
[
"Sitagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]... | Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec and Insulin degludec may cause a moderate interaction that could exacerbate diseases when taken with Teprotumumab
Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Glipi... |
DB06228 | DB06779 | 792 | 365 | [
"DDInter1609",
"DDInter470"
] | Rivaroxaban | Dalteparin | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Major | 2 | [
[
[
792,
25,
365
]
],
[
[
792,
23,
539
],
[
539,
62,
365
]
],
[
[
792,
63,
305
],
[
305,
24,
365
]
],
[
[
792,
24,
1496
],
[
1496,
6... | [
[
[
"Rivaroxaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dalteparin"
]
],
[
[
"Rivaroxaban",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsicum",
... | Rivaroxaban may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Dalteparin
Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia co... |
DB00762 | DB11718 | 613 | 927 | [
"DDInter973",
"DDInter640"
] | Irinotecan | Encorafenib | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
613,
24,
927
]
],
[
[
613,
24,
720
],
[
720,
24,
927
]
],
[
[
613,
63,
536
],
[
536,
24,
927
]
],
[
[
613,
25,
770
],
[
770,
24,... | [
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
],
[
... | Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil and Mineral oil may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Secobarbital and S... |
DB09128 | DB09291 | 1,241 | 741 | [
"DDInter231",
"DDInter1615"
] | Brexpiprazole | Rolapitant | Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to [aripiprazole], brexpiprazole has different b... | Rolapitant is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and vomiting (CINV) in adults. Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated by Neurokinin-1 and its l... | Moderate | 1 | [
[
[
1241,
24,
741
]
],
[
[
1241,
63,
506
],
[
506,
24,
741
]
],
[
[
1241,
24,
159
],
[
159,
63,
741
]
],
[
[
1241,
64,
478
],
[
478,
... | [
[
[
"Brexpiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
]
],
[
[
"Brexpiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextromethorphan"
... | Brexpiprazole may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan and Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant
Brexpiprazole may cause a moderate interaction that could exacerbate diseases when taken with Lar... |
DB06317 | DB10429 | 1,626 | 200 | [
"DDInter630",
"DDInter282"
] | Elotuzumab | Candida albicans | Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family... | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Moderate | 1 | [
[
[
1626,
24,
200
]
],
[
[
1626,
63,
1683
],
[
1683,
24,
200
]
],
[
[
1626,
25,
976
],
[
976,
24,
200
]
],
[
[
1626,
24,
310
],
[
310,
... | [
[
[
"Elotuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
]
],
[
[
"Elotuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
],
... | Elotuzumab may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans
Elotuzumab may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib ... |
DB00641 | DB01254 | 467 | 1,213 | [
"DDInter1675",
"DDInter484"
] | Simvastatin | Dasatinib | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
467,
24,
1213
]
],
[
[
467,
6,
4973
],
[
4973,
45,
1213
]
],
[
[
467,
7,
3466
],
[
3466,
46,
1213
]
],
[
[
467,
18,
4729
],
[
4729,
... | [
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Simvastatin",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Simvastatin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dasatinib (Compound)
Simvastatin (Compound) upregulates CCNA1 (Gene) and CCNA1 (Gene) is upregulated by Dasatinib (Compound)
Simvastatin (Compound) downregulates EBNA1BP2 (Gene) and EBNA1BP2 (Gene) is downregulated by Dasatinib (Compound)
Simvastati... |
DB00704 | DB01045 | 267 | 463 | [
"DDInter1263",
"DDInter1590"
] | Naltrexone | Rifampicin | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Moderate | 1 | [
[
[
267,
24,
463
]
],
[
[
267,
6,
4973
],
[
4973,
45,
463
]
],
[
[
267,
63,
1101
],
[
1101,
23,
463
]
],
[
[
267,
24,
1228
],
[
1228,
... | [
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifampicin"
]
],
[
[
"Naltrexone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Naltrexone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Rifampicin (Compound)
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Rifampicin
Naltrexone may cause a... |
DB00005 | DB00444 | 1,057 | 63 | [
"DDInter687",
"DDInter1765"
] | Etanercept | Teniposide | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Major | 2 | [
[
[
1057,
25,
63
]
],
[
[
1057,
25,
147
],
[
147,
62,
63
]
],
[
[
1057,
24,
1191
],
[
1191,
63,
63
]
],
[
[
1057,
25,
738
],
[
738,
... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teniposide"
]
],
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vinblastine"
],
[
"Vinblastine",
"{u}... | Etanercept may lead to a major life threatening interaction when taken with Vinblastine and Vinblastine may cause a minor interaction that can limit clinical effects when taken with Teniposide
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Levodopa and Levodopa may cause a mo... |
DB00092 | DB11834 | 58 | 1,303 | [
"DDInter40",
"DDInter849"
] | Alefacept | Guselkumab | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Guselkumab is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody that selectively blocks interleukin-23. IL-23 is an inflammatory cytokine that activates the CD4+ T-helper (Th17) cell pathway to mediate the inflammatory cascade that induces psoriatic plaque formation . In clinical trials, guselkumab demonstra... | Moderate | 1 | [
[
[
58,
24,
1303
]
],
[
[
58,
23,
1193
],
[
1193,
23,
1303
]
],
[
[
58,
24,
792
],
[
792,
24,
1303
]
],
[
[
58,
24,
287
],
[
287,
63... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Guselkumab"
]
],
[
[
"Alefacept",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
... | Alefacept may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Guselkumab
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Rivaroxaban and Riv... |
DB01149 | DB01229 | 851 | 973 | [
"DDInter1274",
"DDInter1378"
] | Nefazodone | Paclitaxel (protein-bound) | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Moderate | 1 | [
[
[
851,
24,
973
]
],
[
[
851,
24,
310
],
[
310,
63,
973
]
],
[
[
851,
6,
7524
],
[
7524,
45,
973
]
],
[
[
851,
18,
3390
],
[
3390,
... | [
[
[
"Nefazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Nefazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Nefazodone may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Nefazodone may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Nefazodo... |
DB01076 | DB01098 | 700 | 14 | [
"DDInter133",
"DDInter1622"
] | Atorvastatin | Rosuvastatin | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin... | Moderate | 1 | [
[
[
700,
24,
14
]
],
[
[
700,
40,
671
],
[
671,
24,
14
]
],
[
[
700,
5,
11576
],
[
11576,
44,
14
]
],
[
[
700,
6,
10417
],
[
10417,
... | [
[
[
"Atorvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rosuvastatin"
]
],
[
[
"Atorvastatin",
"{u} (Compound) resembles {v} (Compound)",
"Fluvastatin"
],
[
"Fluvastatin",
"{u} may cause a... | Atorvastatin (Compound) resembles Fluvastatin (Compound) and Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin
Atorvastatin (Compound) treats coronary artery disease (Disease) and coronary artery disease (Disease) is treated by Rosuvastatin (Compound)
Atorvastatin ... |
DB00277 | DB00842 | 1,031 | 686 | [
"DDInter1791",
"DDInter1359"
] | Theophylline | Oxazepam | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Oxazepam is an intermediate-acting, 3-hydroxybenzodiazepine used in the treatment of alcohol withdrawal and anxiety disorders. Oxazepam, like related 3-hydroxybenzodiazepine [lorazepam], is considered less susceptible to pharmacokinetic variability based on patient-specific factors (e.g. age, liver disease) - this feat... | Minor | 0 | [
[
[
1031,
23,
686
]
],
[
[
1031,
23,
1563
],
[
1563,
40,
686
]
],
[
[
1031,
23,
1119
],
[
1119,
1,
686
]
],
[
[
1031,
62,
905
],
[
905,
... | [
[
[
"Theophylline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Oxazepam"
]
],
[
[
"Theophylline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Halazepam"
],
[
... | Theophylline may cause a minor interaction that can limit clinical effects when taken with Halazepam and Halazepam (Compound) resembles Oxazepam (Compound)
Theophylline may cause a minor interaction that can limit clinical effects when taken with Chlordiazepoxide and Chlordiazepoxide (Compound) resembles Oxazepam (Comp... |
DB00186 | DB00366 | 905 | 1,594 | [
"DDInter1092",
"DDInter600"
] | Lorazepam | Doxylamine | Lorazepam is a short-acting and rapidly cleared benzodiazepine used commonly as a sedative and anxiolytic. It was developed by DJ Richards, presented and marketed initially by Wyeth Pharmaceuticals in the USA in 1977. The first historic FDA label approval is reported in 1985 by the company Mutual Pharm. | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Moderate | 1 | [
[
[
905,
24,
1594
]
],
[
[
905,
24,
662
],
[
662,
63,
1594
]
],
[
[
905,
21,
28748
],
[
28748,
60,
1594
]
],
[
[
905,
40,
695
],
[
695,
... | [
[
[
"Lorazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
]
],
[
[
"Lorazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
[
... | Lorazepam may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine
Lorazepam (Compound) causes Vertigo (Side Effect) and Vertigo (Side Effect) is caused by Doxylamine (Compou... |
DB00222 | DB08912 | 245 | 1,040 | [
"DDInter825",
"DDInter462"
] | Glimepiride | Dabrafenib | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
245,
24,
1040
]
],
[
[
245,
21,
28900
],
[
28900,
60,
1040
]
],
[
[
245,
63,
168
],
[
168,
23,
1040
]
],
[
[
245,
24,
1101
],
[
1101,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Glimepiride",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal pain"
],
[
"Abdominal pain",
"{u} (Side Eff... | Glimepiride (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Dabrafenib (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken wi... |
DB00346 | DB08875 | 472 | 1,618 | [
"DDInter44",
"DDInter262"
] | Alfuzosin | Cabozantinib | Benign prostatic hyperplasia (BPH) refers to a benign growth or hyperplasia of the prostate and leads to lower urinary tract symptoms in men, such as urgency, frequency and changes to urine flow. The prevalence of BPH is as high as 50%-60% for males in their 60's, and this prevalence increases to 80%-90% of those over ... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
472,
25,
1618
]
],
[
[
472,
23,
112
],
[
112,
23,
1618
]
],
[
[
472,
24,
723
],
[
723,
24,
1618
]
],
[
[
472,
25,
384
],
[
384,
... | [
[
[
"Alfuzosin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Alfuzosin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronida... | Alfuzosin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Alfuzosin may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Apre... |
DB00877 | DB01024 | 629 | 1,096 | [
"DDInter1678",
"DDInter1252"
] | Sirolimus | Mycophenolic acid | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Moderate | 1 | [
[
[
629,
24,
1096
]
],
[
[
629,
63,
955
],
[
955,
1,
1096
]
],
[
[
629,
7,
4811
],
[
4811,
46,
1096
]
],
[
[
629,
18,
4104
],
[
4104,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolic acid"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolate mofetil"... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolate mofetil and Mycophenolate mofetil (Compound) resembles Mycophenolic acid (Compound)
Sirolimus (Compound) upregulates DUSP6 (Gene) and DUSP6 (Gene) is upregulated by Mycophenolic acid (Compound)
Sirolimus (Compound) d... |
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