drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00163 | DB11767 | 1,461 | 1,583 | [
"DDInter1943",
"DDInter1643"
] | Vitamin E | Sarilumab | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approve... | Minor | 0 | [
[
[
1461,
23,
1583
]
],
[
[
1461,
24,
372
],
[
372,
24,
1583
]
],
[
[
1461,
62,
58
],
[
58,
24,
1583
]
],
[
[
1461,
23,
629
],
[
629,
... | [
[
[
"Vitamin E",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sarilumab"
]
],
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
],
[
... | Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Sarilumab
Vitamin E may cause a minor interaction that can limit clinical effects when taken with Alefacept and Alefacept ... |
DB01177 | DB10343 | 77 | 962 | [
"DDInter904",
"DDInter160"
] | Idarubicin | Bacillus calmette-guerin substrain tice live antigen | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Bacillus calmette-guerin substrain tice live antigen is a vaccine containing attenuated live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of *Mycobacterium bovis* for percutaneous use. It is administered to prevent the development of tuberculosis. | Major | 2 | [
[
[
77,
25,
962
]
],
[
[
77,
64,
1057
],
[
1057,
25,
962
]
],
[
[
77,
24,
1342
],
[
1342,
25,
962
]
],
[
[
77,
24,
270
],
[
270,
64,... | [
[
[
"Idarubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bacillus calmette-guerin substrain tice live antigen"
]
],
[
[
"Idarubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
... | Idarubicin may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Bacillus calmette-guerin substrain tice live antigen
Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Romidepsi... |
DB01021 | DB09564 | 674 | 1,296 | [
"DDInter1861",
"DDInter930"
] | Trichlormethiazide | Insulin degludec | A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830) | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
674,
24,
1296
]
],
[
[
674,
24,
1411
],
[
1411,
24,
1296
]
],
[
[
674,
63,
1645
],
[
1645,
24,
1296
]
],
[
[
674,
62,
964
],
[
964,
... | [
[
[
"Trichlormethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Trichlormethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbu... | Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00420 | DB01069 | 508 | 401 | [
"DDInter1532",
"DDInter1533"
] | Promazine | Promethazine | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
508,
35,
401
]
],
[
[
508,
40,
11245
],
[
11245,
1,
401
]
],
[
[
508,
1,
146
],
[
146,
24,
401
]
],
[
[
508,
1,
11275
],
[
11275,
... | [
[
[
"Promazine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Promazine",
"{u} (Compound) resembles {v} (Compound)",
"Ethopropazine"
],
[
... | Promazine (Compound) resembles Promethazine (Compound) and
Promazine (Compound) resembles Ethopropazine (Compound) and Ethopropazine (Compound) resembles Promethazine (Compound)
Promazine (Compound) resembles Propiomazine (Compound) and Propiomazine may cause a moderate interaction that could exacerbate diseases when t... |
DB00675 | DB01224 | 888 | 623 | [
"DDInter1744",
"DDInter1553"
] | Tamoxifen | Quetiapine | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Moderate | 1 | [
[
[
888,
24,
623
]
],
[
[
888,
63,
827
],
[
827,
1,
623
]
],
[
[
888,
24,
851
],
[
851,
1,
623
]
],
[
[
888,
64,
695
],
[
695,
1,
... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quetiapine"
]
],
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trazodone"
],
[
... | Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Trazodone and Trazodone (Compound) resembles Quetiapine (Compound)
Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Nefazodone and Nefazodone (Compound) resembles Quetiapine (Compound)
Tamo... |
DB00635 | DB01276 | 1,573 | 123 | [
"DDInter1515",
"DDInter706"
] | Prednisone | Exenatide | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Moderate | 1 | [
[
[
1573,
24,
123
]
],
[
[
1573,
63,
1252
],
[
1252,
23,
123
]
],
[
[
1573,
40,
1103
],
[
1103,
23,
123
]
],
[
[
1573,
23,
1072
],
[
1072,... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
]
],
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digoxin"
],
[
... | Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin may cause a minor interaction that can limit clinical effects when taken with Exenatide
Prednisone (Compound) resembles Amcinonide (Compound) and Amcinonide may cause a minor interaction that can limit clinica... |
DB00960 | DB01309 | 887 | 1,254 | [
"DDInter1471",
"DDInter933"
] | Pindolol | Insulin glulisine | Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the earl... | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
887,
24,
1254
]
],
[
[
887,
63,
167
],
[
167,
24,
1254
]
],
[
[
887,
24,
1220
],
[
1220,
24,
1254
]
],
[
[
887,
25,
480
],
[
480,
... | [
[
[
"Pindolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Pindolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
],
... | Pindolol may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine
Pindolol may cause a moderate interaction that could exacerbate diseases when taken with Dexamethas... |
DB00490 | DB01075 | 946 | 1,376 | [
"DDInter254",
"DDInter569"
] | Buspirone | Diphenhydramine | Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class, buspirone is a serotonin 5-HT<sub>1A</sub> receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic dr... | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
946,
24,
1376
]
],
[
[
946,
24,
649
],
[
649,
63,
1376
]
],
[
[
946,
63,
128
],
[
128,
24,
1376
]
],
[
[
946,
24,
832
],
[
832,
... | [
[
[
"Buspirone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Buspirone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],
[... | Buspirone may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Buspirone may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine... |
DB08901 | DB15328 | 1,468 | 829 | [
"DDInter1492",
"DDInter1896"
] | Ponatinib | Ubrogepant | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Ubrogepant is indicated for the acute treatment of migraine headaches with or without aura in adults. It was approved by the FDA on December 23, 2019, and is the first oral calcitonin gene-related peptide (CGRP) receptor antagonist approved for the acute treatment of migraine. Several oral small molecule CGRP receptor ... | Moderate | 1 | [
[
[
1468,
24,
829
]
],
[
[
1468,
24,
1476
],
[
1476,
24,
829
]
],
[
[
1468,
64,
578
],
[
578,
24,
829
]
],
[
[
1468,
63,
868
],
[
868,
... | [
[
[
"Ponatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ubrogepant"
]
],
[
[
"Ponatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
],
[
... | Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Ubrogepant
Ponatinib may lead to a major life threatening interaction when taken with Ticagrelor and Ticagrelor may cause a ... |
DB00447 | DB01024 | 1,457 | 1,096 | [
"DDInter1090",
"DDInter1252"
] | Loracarbef | Mycophenolic acid | Loracarbef is a carbacephem antibiotic sometimes grouped together with the second-generation cephalosporin antibiotics. It is marketed under the trade name Lorabid. | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Moderate | 1 | [
[
[
1457,
24,
1096
]
],
[
[
1457,
63,
597
],
[
597,
24,
1096
]
],
[
[
1457,
24,
1662
],
[
1662,
63,
597
],
[
597,
24,
1096
]
],
[
[
1457,
... | [
[
[
"Loracarbef",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolic acid"
]
],
[
[
"Loracarbef",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphenicol"
... | Loracarbef may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid
Loracarbef may cause a moderate interaction that could exacerbate diseases when taken with Pico... |
DB00970 | DB08868 | 0 | 1,011 | [
"DDInter466",
"DDInter737"
] | Dactinomycin | Fingolimod | A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also d... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
0,
25,
1011
]
],
[
[
0,
21,
29203
],
[
29203,
60,
1011
]
],
[
[
0,
24,
748
],
[
748,
63,
1011
]
],
[
[
0,
24,
1136
],
[
1136,
24... | [
[
[
"Dactinomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Dactinomycin",
"{u} (Compound) causes {v} (Side Effect)",
"Aspartate aminotransferase increased"
],
[
"Aspartate aminotransferase i... | Dactinomycin (Compound) causes Aspartate aminotransferase increased (Side Effect) and Aspartate aminotransferase increased (Side Effect) is caused by Fingolimod (Compound)
Dactinomycin may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine and Anthrax vaccine may cause a moderat... |
DB00563 | DB00595 | 663 | 1,545 | [
"DDInter1174",
"DDInter1374"
] | Methotrexate | Oxytetracycline | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | A tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety of clinical conditions. | Moderate | 1 | [
[
[
663,
24,
1545
]
],
[
[
663,
63,
964
],
[
964,
1,
1545
]
],
[
[
663,
24,
1620
],
[
1620,
1,
1545
]
],
[
[
663,
6,
16560
],
[
16560,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxytetracycline"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxycycline"
]... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Doxycycline and Doxycycline (Compound) resembles Oxytetracycline (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Tetracycline and Tetracycline (Compound) resembles Oxytetr... |
DB00277 | DB01362 | 1,031 | 497 | [
"DDInter1791",
"DDInter960"
] | Theophylline | Iohexol | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
1031,
25,
497
]
],
[
[
1031,
21,
28681
],
[
28681,
60,
497
]
],
[
[
1031,
25,
1523
],
[
1523,
24,
497
]
],
[
[
1031,
64,
88
],
[
88,
... | [
[
[
"Theophylline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Theophylline",
"{u} (Compound) causes {v} (Side Effect)",
"Hypersensitivity"
],
[
"Hypersensitivity",
"{u} (Side Effect) is caus... | Theophylline (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Iohexol (Compound)
Theophylline may lead to a major life threatening interaction when taken with Labetalol and Labetalol may cause a moderate interaction that could exacerbate diseases when taken with Iohexol
T... |
DB00661 | DB04845 | 122 | 309 | [
"DDInter1928",
"DDInter1001"
] | Verapamil | Ixabepilone | Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Moderate | 1 | [
[
[
122,
24,
309
]
],
[
[
122,
6,
8374
],
[
8374,
45,
309
]
],
[
[
122,
21,
29434
],
[
29434,
60,
309
]
],
[
[
122,
63,
1419
],
[
1419,
... | [
[
[
"Verapamil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
]
],
[
[
"Verapamil",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Verapamil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ixabepilone (Compound)
Verapamil (Compound) causes Angina pectoris (Side Effect) and Angina pectoris (Side Effect) is caused by Ixabepilone (Compound)
Verapamil may cause a moderate interaction that could exacerbate diseases when taken with Imatinib... |
DB00999 | DB13142 | 504 | 841 | [
"DDInter883",
"DDInter274"
] | Hydrochlorothiazide | Calcium glubionate anhydrous | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Calcium glubionate (or glubionate calcium) is a mineral supplement to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets. | Moderate | 1 | [
[
[
504,
24,
841
]
],
[
[
504,
23,
1669
],
[
1669,
24,
841
]
],
[
[
504,
62,
1545
],
[
1545,
24,
841
]
],
[
[
504,
1,
674
],
[
674,
... | [
[
[
"Hydrochlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium glubionate anhydrous"
]
],
[
[
"Hydrochlorothiazide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
... | Hydrochlorothiazide may cause a minor interaction that can limit clinical effects when taken with Minocycline and Minocycline may cause a moderate interaction that could exacerbate diseases when taken with Calcium glubionate anhydrous
Hydrochlorothiazide may cause a minor interaction that can limit clinical effects whe... |
DB04837 | DB11186 | 649 | 1,609 | [
"DDInter407",
"DDInter1427"
] | Clofedanol | Pentoxyverine | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
649,
24,
1609
]
],
[
[
649,
63,
314
],
[
314,
24,
1609
]
],
[
[
649,
1,
508
],
[
508,
24,
1609
]
],
[
[
649,
24,
1580
],
[
1580,
... | [
[
[
"Clofedanol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Clofedanol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nalbuphine"
],
[... | Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Nalbuphine and Nalbuphine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Clofedanol (Compound) resembles Promazine (Compound) and Promazine may cause a moderate interaction that coul... |
DB01069 | DB08815 | 401 | 154 | [
"DDInter1533",
"DDInter1104"
] | Promethazine | Lurasidone | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States. | Moderate | 1 | [
[
[
401,
24,
154
]
],
[
[
401,
6,
2250
],
[
2250,
45,
154
]
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[
[
401,
21,
28963
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[
28963,
60,
154
]
],
[
[
401,
24,
1619
],
[
1619,
... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurasidone"
]
],
[
[
"Promethazine",
"{u} (Compound) binds {v} (Gene)",
"DRD2"
],
[
"DRD2",
"{u} (Gene) is bound by {v} (Compound)",... | Promethazine (Compound) binds DRD2 (Gene) and DRD2 (Gene) is bound by Lurasidone (Compound)
Promethazine (Compound) causes Anxiety (Side Effect) and Anxiety (Side Effect) is caused by Lurasidone (Compound)
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucapar... |
DB00472 | DB08871 | 758 | 36 | [
"DDInter758",
"DDInter666"
] | Fluoxetine | Eribulin | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
758,
24,
36
]
],
[
[
758,
63,
1424
],
[
1424,
24,
36
]
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[
[
758,
24,
820
],
[
820,
24,
36
]
],
[
[
758,
24,
28
],
[
28,
63,
... | [
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinine"
],
[
"... | Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinine may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine m... |
DB01142 | DB01583 | 1,264 | 624 | [
"DDInter593",
"DDInter1075"
] | Doxepin | Liotrix | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Liotrix is a synthetically derived thyroid hormone replacement preparation. It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in a 4 to 1 ratio by weight. Liotrix was developed when it was believed that serum levels of both T4 and T3 were maintained by direct thyroidal s... | Moderate | 1 | [
[
[
1264,
24,
624
]
],
[
[
1264,
63,
1152
],
[
1152,
1,
624
]
],
[
[
1264,
63,
542
],
[
542,
40,
624
]
],
[
[
1264,
6,
4973
],
[
4973,
... | [
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liotrix"
]
],
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liothyronine"
],
[
"Li... | Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Liothyronine and Liothyronine (Compound) resembles Liotrix (Compound)
Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Levothyroxine and Levothyroxine (Compound) resembles Liotrix (Compound)
Do... |
DB00501 | DB08930 | 752 | 1,459 | [
"DDInter380",
"DDInter582"
] | Cimetidine | Dolutegravir | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Dolutegravir is an HIV-1 integrase inhibitor that blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI). The effect of this drug has no homology in human host cells, which gives it excellent tolerability and minimal toxicity. Dolutegravir was developed by ViiV Healthcare and ... | Minor | 0 | [
[
[
752,
23,
1459
]
],
[
[
752,
21,
28722
],
[
28722,
60,
1459
]
],
[
[
752,
24,
1419
],
[
1419,
23,
1459
]
],
[
[
752,
25,
1213
],
[
1213... | [
[
[
"Cimetidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dolutegravir"
]
],
[
[
"Cimetidine",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused by ... | Cimetidine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Dolutegravir (Compound)
Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a minor interaction that can limit clinical effects when taken with Dolutegravir
Cime... |
DB01619 | DB09272 | 830 | 412 | [
"DDInter1441",
"DDInter632"
] | Phenindamine | Eluxadoline | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Eluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D). The mu-, kappa-, and delta-opioid receptors mediate endogenous and exogenous opioid response in the central nervous system ... | Moderate | 1 | [
[
[
830,
24,
412
]
],
[
[
830,
63,
1594
],
[
1594,
24,
412
]
],
[
[
830,
24,
849
],
[
849,
24,
412
]
],
[
[
830,
1,
1219
],
[
1219,
... | [
[
[
"Phenindamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eluxadoline"
]
],
[
[
"Phenindamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
... | Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Eluxadoline
Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and M... |
DB00450 | DB00816 | 78 | 1,674 | [
"DDInter603",
"DDInter1346"
] | Droperidol | Orciprenaline | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Major | 2 | [
[
[
78,
25,
1674
]
],
[
[
78,
24,
874
],
[
874,
24,
1674
]
],
[
[
78,
21,
28921
],
[
28921,
60,
1674
]
],
[
[
78,
25,
167
],
[
167,
... | [
[
[
"Droperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Orciprenaline"
]
],
[
[
"Droperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
],
[
"Epinep... | Droperidol may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Orciprenaline
Droperidol (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Orciprenaline... |
DB00342 | DB14740 | 1,181 | 771 | [
"DDInter1770",
"DDInter881"
] | Terfenadine | Hyaluronidase | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Hyaluronidase is an enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents. The action of hyaluronidase was first described in 1936, and named in 1939. Early research into hyaluronidase identified it as a "spreading factor" which allowed for increased permea... | Minor | 0 | [
[
[
1181,
23,
771
]
],
[
[
1181,
24,
252
],
[
252,
23,
771
]
],
[
[
1181,
24,
252
],
[
252,
24,
849
],
[
849,
23,
771
]
],
[
[
1181,
... | [
[
[
"Terfenadine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
]
],
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyzine"
],
... | Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyzine and Hydroxyzine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyzine and ... |
DB06603 | DB09068 | 39 | 1,427 | [
"DDInter1387",
"DDInter1948"
] | Panobinostat | Vortioxetine | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin r... | Major | 2 | [
[
[
39,
25,
1427
]
],
[
[
39,
24,
1320
],
[
1320,
63,
1427
]
],
[
[
39,
64,
25
],
[
25,
24,
1427
]
],
[
[
39,
25,
802
],
[
802,
24,
... | [
[
[
"Panobinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vortioxetine"
]
],
[
[
"Panobinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
],
[
"Elagol... | Panobinostat may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elagolix may cause a moderate interaction that could exacerbate diseases when taken with Vortioxetine
Panobinostat may lead to a major life threatening interaction when taken with Anistreplase and Anistreplase may ... |
DB00352 | DB00544 | 482 | 970 | [
"DDInter1814",
"DDInter757"
] | Tioguanine | Fluorouracil | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. | Moderate | 1 | [
[
[
482,
24,
970
]
],
[
[
482,
6,
9320
],
[
9320,
45,
970
]
],
[
[
482,
21,
28725
],
[
28725,
60,
970
]
],
[
[
482,
23,
945
],
[
945,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluorouracil"
]
],
[
[
"Tioguanine",
"{u} (Compound) binds {v} (Gene)",
"ABCC4"
],
[
"ABCC4",
"{u} (Gene) is bound by {v} (Compound)",... | Tioguanine (Compound) binds ABCC4 (Gene) and ABCC4 (Gene) is bound by Fluorouracil (Compound)
Tioguanine (Compound) causes Pancytopenia (Side Effect) and Pancytopenia (Side Effect) is caused by Fluorouracil (Compound)
Tioguanine may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin ... |
DB00738 | DB09564 | 485 | 1,296 | [
"DDInter1420",
"DDInter930"
] | Pentamidine | Insulin degludec | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
485,
24,
1296
]
],
[
[
485,
64,
17
],
[
17,
24,
1296
]
],
[
[
485,
24,
1411
],
[
1411,
24,
1296
]
],
[
[
485,
63,
1645
],
[
1645,
... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Pentamidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sotalol"
],
[
"Sotal... | Pentamidine may lead to a major life threatening interaction when taken with Sotalol and Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may ca... |
DB05773 | DB09276 | 1,047 | 381 | [
"DDInter1848",
"DDInter1682"
] | Trastuzumab emtansine | Sodium aurothiomalate | Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent, DM1. T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-mic... | Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in active progressive rheumatoid arthritis and of little or no valu... | Moderate | 1 | [
[
[
1047,
24,
381
]
],
[
[
1047,
63,
491
],
[
491,
24,
381
]
],
[
[
1047,
64,
4
],
[
4,
24,
381
]
],
[
[
1047,
24,
1626
],
[
1626,
2... | [
[
[
"Trastuzumab emtansine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium aurothiomalate"
]
],
[
[
"Trastuzumab emtansine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Trastuzumab emtansine may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2a and Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Sodium aurothiomalate
Trastuzumab emtansine may lead to a major life threatening interacti... |
DB00004 | DB01097 | 669 | 1,377 | [
"DDInter499",
"DDInter1033"
] | Denileukin diftitox | Leflunomide | A recombinant DNA-derived cytotoxic protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met 1-Thr 387)-His followed by the sequences for interleukin-2 (IL-2; Ala 1-Thr 133). It is produced in an E. coli expression system. | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
669,
25,
1377
]
],
[
[
669,
24,
949
],
[
949,
63,
1377
]
],
[
[
669,
24,
563
],
[
563,
24,
1377
]
],
[
[
669,
24,
66
],
[
66,
25... | [
[
[
"Denileukin diftitox",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Denileukin diftitox",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxo... | Denileukin diftitox may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated) and Clostridium tetani toxoid antigen (formaldehyde inactivated) may cause a moderate interaction that could exacerbate diseases when taken with Leflunomide
De... |
DB00041 | DB00218 | 1,648 | 1,176 | [
"DDInter38",
"DDInter1247"
] | Aldesleukin | Moxifloxacin | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Minor | 0 | [
[
[
1648,
23,
1176
]
],
[
[
1648,
23,
945
],
[
945,
40,
1176
]
],
[
[
1648,
24,
37
],
[
37,
62,
1176
]
],
[
[
1648,
25,
611
],
[
611,
... | [
[
[
"Aldesleukin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Moxifloxacin"
]
],
[
[
"Aldesleukin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sparfloxacin"
],
[
... | Aldesleukin may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Moxifloxacin (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Lomustine and Lomustine may cause a minor interaction that can ... |
DB00075 | DB14783 | 541 | 287 | [
"DDInter1250",
"DDInter574"
] | Muromonab | Diroximel fumarate | Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Muromonab is 93% monomeric immune globulin G type... | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
541,
24,
287
]
],
[
[
541,
24,
599
],
[
599,
24,
287
]
],
[
[
541,
63,
1184
],
[
1184,
24,
287
]
],
[
[
541,
25,
1510
],
[
1510,
... | [
[
[
"Muromonab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Muromonab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alemtuzumab"
],
... | Muromonab may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab and Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Muromonab may cause a moderate interaction that could exacerbate diseases when taken with Anakinra and ... |
DB00388 | DB01124 | 1,636 | 1,411 | [
"DDInter1453",
"DDInter1828"
] | Phenylephrine | Tolbutamide | Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939. | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
1636,
24,
1411
]
],
[
[
1636,
24,
959
],
[
959,
40,
1411
]
],
[
[
1636,
63,
245
],
[
245,
40,
1411
]
],
[
[
1636,
21,
28680
],
[
28680... | [
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
... | Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Tolbutamide (Co... |
DB01219 | DB04837 | 716 | 649 | [
"DDInter473",
"DDInter407"
] | Dantrolene | Clofedanol | Chemically, dantrolene is a hydantoin derivative, but does not exhibit antiepileptic activity like other hydantoin derivates such as phenytoin. | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
716,
24,
649
]
],
[
[
716,
63,
1376
],
[
1376,
24,
649
]
],
[
[
716,
63,
832
],
[
832,
40,
649
]
],
[
[
716,
24,
820
],
[
820,
4... | [
[
[
"Dantrolene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Dantrolene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
... | Dantrolene may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Dantrolene may cause a moderate interaction that could exacerbate diseases when taken with Tripelennam... |
DB01041 | DB09117 | 770 | 957 | [
"DDInter1789",
"DDInter1391"
] | Thalidomide | Paraldehyde | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Paraldehyde was initially introduced into medical practice in the United Kingdom in 1882 by the Italian physician Vincenzo Cervello. It is classified as a central nervous system (CNS) depressant and has also been found to be an effective anticonvulsant, hypnotic and sedative agent due to its CNS depressant properties. ... | Moderate | 1 | [
[
[
770,
24,
957
]
],
[
[
770,
24,
1264
],
[
1264,
24,
957
]
],
[
[
770,
64,
1648
],
[
1648,
24,
957
]
],
[
[
770,
25,
1532
],
[
1532,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paraldehyde"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Paraldehyde
Thalidomide may lead to a major life threatening interaction when taken with Aldesleukin and Aldesleukin may cause a... |
DB00704 | DB01209 | 267 | 1,359 | [
"DDInter1263",
"DDInter531"
] | Naltrexone | Dezocine | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Dezocine is a partial opiate drug and is used for pain management. Dezocine is a very effective alternative to fentanyl when administered during outpatient laparoscopy, although is associated with an increased incidence of postoperative nausea. | Major | 2 | [
[
[
267,
25,
1359
]
],
[
[
267,
64,
234
],
[
234,
1,
1359
]
],
[
[
267,
40,
926
],
[
926,
1,
1359
]
],
[
[
267,
6,
7940
],
[
7940,
4... | [
[
[
"Naltrexone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dezocine"
]
],
[
[
"Naltrexone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pentazocine"
],
[
"Pentazocine",
"{u} (... | Naltrexone may lead to a major life threatening interaction when taken with Pentazocine and Pentazocine (Compound) resembles Dezocine (Compound)
Naltrexone (Compound) resembles Butorphanol (Compound) and Butorphanol (Compound) resembles Dezocine (Compound)
Naltrexone (Compound) binds OPRK1 (Gene) and OPRK1 (Gene) is bo... |
DB00674 | DB01169 | 1,516 | 57 | [
"DDInter802",
"DDInter120"
] | Galantamine | Arsenic trioxide | Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease. First characterized in the early 1950s, galantamine is a tertiary alkaloid that was extracted from botanical sour... | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Moderate | 1 | [
[
[
1516,
24,
57
]
],
[
[
1516,
6,
8374
],
[
8374,
45,
57
]
],
[
[
1516,
24,
112
],
[
112,
23,
57
]
],
[
[
1516,
24,
144
],
[
144,
6... | [
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Arsenic trioxide"
]
],
[
[
"Galantamine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Com... | Galantamine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Arsenic trioxide (Compound)
Galantamine may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Arsenic trioxide
... |
DB01024 | DB01328 | 1,096 | 1,323 | [
"DDInter1252",
"DDInter321"
] | Mycophenolic acid | Cefonicid | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | A second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections. | Moderate | 1 | [
[
[
1096,
24,
1323
]
],
[
[
1096,
24,
665
],
[
665,
40,
1323
]
],
[
[
1096,
63,
164
],
[
164,
40,
1323
]
],
[
[
1096,
24,
1227
],
[
1227,
... | [
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefonicid"
]
],
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefuroxime"
... | Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Cefuroxime and Cefuroxime (Compound) resembles Cefonicid (Compound)
Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Cefalotin and Cefalotin (Compound) resembles Cefonicid (... |
DB00207 | DB00445 | 1,570 | 322 | [
"DDInter157",
"DDInter655"
] | Azithromycin | Epirubicin | Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It was initially approved by the FDA in 1991. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually tra... | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Moderate | 1 | [
[
[
1570,
24,
322
]
],
[
[
1570,
7,
9242
],
[
9242,
46,
322
]
],
[
[
1570,
18,
9205
],
[
9205,
57,
322
]
],
[
[
1570,
21,
28970
],
[
28970... | [
[
[
"Azithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
]
],
[
[
"Azithromycin",
"{u} (Compound) upregulates {v} (Gene)",
"WDR7"
],
[
"WDR7",
"{u} (Gene) is upregulated by {v} ... | Azithromycin (Compound) upregulates WDR7 (Gene) and WDR7 (Gene) is upregulated by Epirubicin (Compound)
Azithromycin (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is downregulated by Epirubicin (Compound)
Azithromycin (Compound) causes Dry eye (Side Effect) and Dry eye (Side Effect) is caused by Epirubicin (Co... |
DB06168 | DB10276 | 1,531 | 1,624 | [
"DDInter281",
"DDInter1623"
] | Canakinumab | Rotavirus vaccine | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Major | 2 | [
[
[
1531,
25,
1624
]
],
[
[
1531,
63,
617
],
[
617,
24,
1624
]
],
[
[
1531,
63,
552
],
[
552,
25,
1624
]
],
[
[
1531,
25,
1583
],
[
1583,
... | [
[
[
"Canakinumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Canakinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Budesonide"
],
[
"B... | Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Rotavirus vaccine
Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Carmustine a... |
DB09068 | DB09241 | 1,427 | 1,629 | [
"DDInter1948",
"DDInter1186"
] | Vortioxetine | Methylene blue | Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin r... | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Major | 2 | [
[
[
1427,
25,
1629
]
],
[
[
1427,
63,
1311
],
[
1311,
24,
1629
]
],
[
[
1427,
64,
73
],
[
73,
25,
1629
]
],
[
[
1427,
63,
475
],
[
475,
... | [
[
[
"Vortioxetine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylene blue"
]
],
[
[
"Vortioxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
],
[
... | Vortioxetine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Vortioxetine may lead to a major life threatening interaction when taken with Phentermine and Phen... |
DB09146 | DB12035 | 489 | 943 | [
"DDInter978",
"DDInter1641"
] | Iron sucrose | Sarecycline | Iron sucrose (sucroferric oxyhydroxide or iron saccharate) is used as a source of iron in patients with iron deficiency anemia with chronic kidney disease (CKD), including those who are undergoing dialysis (hemodialysis or peritoneal) and those who do not require dialysis. Due to less side effects than iron dextran, ir... | Sarecycline is a semi-synthetic derivative of tetracycline that was initially discovered by Paratek Pharmaceuticals from Boston, MA but then licensed to Warner Chilcott of Rockaway, NJ in July of 2007 . After completing various phase-II and phase-III trials demonstrating its effectiveness in treating moderate to severe... | Moderate | 1 | [
[
[
489,
24,
943
]
],
[
[
489,
63,
1596
],
[
1596,
24,
943
]
],
[
[
489,
24,
428
],
[
428,
63,
943
]
],
[
[
489,
63,
1596
],
[
1596,
... | [
[
[
"Iron sucrose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarecycline"
]
],
[
[
"Iron sucrose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron"
],
[
... | Iron sucrose may cause a moderate interaction that could exacerbate diseases when taken with Iron and Iron may cause a moderate interaction that could exacerbate diseases when taken with Sarecycline
Iron sucrose may cause a moderate interaction that could exacerbate diseases when taken with Ferrous fumarate and Ferrous... |
DB00431 | DB01576 | 1,503 | 93 | [
"DDInter1072",
"DDInter526"
] | Lindane | Dextroamphetamine | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | Dextroamphetamine is the dextrorotatory enantiomer of amphetamine. Dextroamphetamine was approved by the FDA in 2001 for the treatment of attention deficit hyperactivity disorder[L6010,Label]. | Moderate | 1 | [
[
[
1503,
24,
93
]
],
[
[
1503,
63,
73
],
[
73,
1,
93
]
],
[
[
1503,
63,
80
],
[
80,
40,
93
]
],
[
[
1503,
24,
1529
],
[
1529,
40,
... | [
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextroamphetamine"
]
],
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phentermine"
],
[
... | Lindane may cause a moderate interaction that could exacerbate diseases when taken with Phentermine and Phentermine (Compound) resembles Dextroamphetamine (Compound)
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Amphetamine and Amphetamine (Compound) resembles Dextroamphetamine... |
DB01129 | DB06817 | 379 | 809 | [
"DDInter1559",
"DDInter1563"
] | Rabeprazole | Raltegravir | Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion. | Raltegravir is an antiretroviral drug produced by Merck & Co., used to treat HIV infection. It received approval by the U.S. Food and Drug Administration (FDA) on 12 October 2007, the first of a new class of HIV drugs, the integrase inhibitors, to receive such approval. | Minor | 0 | [
[
[
379,
23,
809
]
],
[
[
379,
21,
29169
],
[
29169,
60,
809
]
],
[
[
379,
24,
478
],
[
478,
23,
809
]
],
[
[
379,
40,
660
],
[
660,
... | [
[
[
"Rabeprazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Raltegravir"
]
],
[
[
"Rabeprazole",
"{u} (Compound) causes {v} (Side Effect)",
"Tinnitus"
],
[
"Tinnitus",
"{u} (Side Effect) is cause... | Rabeprazole (Compound) causes Tinnitus (Side Effect) and Tinnitus (Side Effect) is caused by Raltegravir (Compound)
Rabeprazole may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a minor interaction that can limit clinical effects when taken with Raltegravi... |
DB00092 | DB01182 | 58 | 371 | [
"DDInter40",
"DDInter1534"
] | Alefacept | Propafenone | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. | Moderate | 1 | [
[
[
58,
24,
371
]
],
[
[
58,
24,
704
],
[
704,
1,
371
]
],
[
[
58,
24,
608
],
[
608,
23,
371
]
],
[
[
58,
24,
126
],
[
126,
24,
... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propafenone"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fentanyl"
],
[
... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl (Compound) resembles Propafenone (Compound)
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clini... |
DB00081 | DB09498 | 273 | 810 | [
"DDInter1838",
"DDInter1715"
] | Tositumomab | Strontium chloride Sr-89 | Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Moderate | 1 | [
[
[
273,
24,
810
]
],
[
[
273,
24,
597
],
[
597,
24,
810
]
],
[
[
273,
25,
503
],
[
503,
63,
810
]
],
[
[
273,
25,
1468
],
[
1468,
2... | [
[
[
"Tositumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Strontium chloride Sr-89"
]
],
[
[
"Tositumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphen... | Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89
Tositumomab may lead to a major life threatening interaction when taken with Zanubrutin... |
DB00352 | DB00582 | 482 | 1,622 | [
"DDInter1814",
"DDInter1946"
] | Tioguanine | Voriconazole | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Moderate | 1 | [
[
[
482,
24,
1622
]
],
[
[
482,
21,
29679
],
[
29679,
60,
1622
]
],
[
[
482,
24,
663
],
[
663,
24,
1622
]
],
[
[
482,
24,
1419
],
[
1419,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Voriconazole"
]
],
[
[
"Tioguanine",
"{u} (Compound) causes {v} (Side Effect)",
"Ascites"
],
[
"Ascites",
"{u} (Side Effect) is caused... | Tioguanine (Compound) causes Ascites (Side Effect) and Ascites (Side Effect) is caused by Voriconazole (Compound)
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Voric... |
DB06616 | DB14568 | 594 | 982 | [
"DDInter224",
"DDInter1000"
] | Bosutinib | Ivosidenib | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
594,
25,
982
]
],
[
[
594,
62,
112
],
[
112,
23,
982
]
],
[
[
594,
63,
1101
],
[
1101,
23,
982
]
],
[
[
594,
25,
976
],
[
976,
2... | [
[
[
"Bosutinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Bosutinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidazo... | Bosutinib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexaro... |
DB09420 | DB11071 | 1,074 | 1,004 | [
"DDInter953",
"DDInter1449"
] | Iodide I-123 | Phenyl salicylate | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Phenyl salicylate is a 2-hydroxybenzoic acid phenyl ester. It is utilized in some manufacturing processes of polymers, lacquers, adhesives, waxes, as well as polishes. It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing salicylate (found in ). Phenyl salicylate ma... | Moderate | 1 | [
[
[
1074,
24,
1004
]
],
[
[
1074,
63,
500
],
[
500,
24,
1004
]
],
[
[
1074,
24,
235
],
[
235,
63,
1004
]
],
[
[
1074,
63,
500
],
[
500,
... | [
[
[
"Iodide I-123",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyl salicylate"
]
],
[
[
"Iodide I-123",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enoxaparin"
... | Iodide I-123 may cause a moderate interaction that could exacerbate diseases when taken with Enoxaparin and Enoxaparin may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate
Iodide I-123 may cause a moderate interaction that could exacerbate diseases when taken with Desirudin ... |
DB01410 | DB04865 | 423 | 4 | [
"DDInter375",
"DDInter1335"
] | Ciclesonide | Omacetaxine mepesuccinate | Ciclesonide is a glucocorticoid used to treat obstructive airway diseases. It is marketed under the brand name Alvesco. | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
423,
24,
4
]
],
[
[
423,
6,
1899
],
[
1899,
46,
4
]
],
[
[
423,
40,
218
],
[
218,
24,
4
]
],
[
[
423,
1,
617
],
[
617,
24,
... | [
[
[
"Ciclesonide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Ciclesonide",
"{u} (Compound) binds {v} (Gene)",
"NR3C1"
],
[
"NR3C1",
"{u} (Gene) is upregulate... | Ciclesonide (Compound) binds NR3C1 (Gene) and NR3C1 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Ciclesonide (Compound) resembles Beclomethasone dipropionate (Compound) and Beclomethasone dipropionate may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccin... |
DB00009 | DB01254 | 1,271 | 1,213 | [
"DDInter56",
"DDInter484"
] | Alteplase | Dasatinib | Alteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent. It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots. In the absence of fibrin, the alteplase-mediated conversion of plasminogen is limited, thanks to the high affinity between alteplas... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Major | 2 | [
[
[
1271,
25,
1213
]
],
[
[
1271,
23,
539
],
[
539,
62,
1213
]
],
[
[
1271,
24,
738
],
[
738,
63,
1213
]
],
[
[
1271,
24,
383
],
[
383,
... | [
[
[
"Alteplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
]
],
[
[
"Alteplase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsicum",
... | Alteplase may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Dasatinib
Alteplase may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib may caus... |
DB00501 | DB06209 | 752 | 256 | [
"DDInter380",
"DDInter1508"
] | Cimetidine | Prasugrel | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversib... | Minor | 0 | [
[
[
752,
23,
256
]
],
[
[
752,
6,
10215
],
[
10215,
45,
256
]
],
[
[
752,
21,
28681
],
[
28681,
60,
256
]
],
[
[
752,
23,
593
],
[
593,
... | [
[
[
"Cimetidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Prasugrel"
]
],
[
[
"Cimetidine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compound)",
... | Cimetidine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Prasugrel (Compound)
Cimetidine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Prasugrel (Compound)
Cimetidine may cause a minor interaction that can limit clinical effects when taken with Bupropi... |
DB00065 | DB00741 | 581 | 167 | [
"DDInter923",
"DDInter885"
] | Infliximab | Hydrocortisone | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Major | 2 | [
[
[
581,
25,
167
]
],
[
[
581,
25,
1220
],
[
1220,
40,
167
]
],
[
[
581,
24,
303
],
[
303,
40,
167
]
],
[
[
581,
25,
870
],
[
870,
1... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydrocortisone"
]
],
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexamethasone"
],
[
"Dexamethasone",
... | Infliximab may lead to a major life threatening interaction when taken with Dexamethasone and Dexamethasone (Compound) resembles Hydrocortisone (Compound)
Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Medroxyprogesterone acetate and Medroxyprogesterone acetate (Compound) res... |
DB00421 | DB11793 | 443 | 738 | [
"DDInter1707",
"DDInter1297"
] | Spironolactone | Niraparib | Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were disco... | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
443,
24,
738
]
],
[
[
443,
24,
1619
],
[
1619,
63,
738
]
],
[
[
443,
24,
848
],
[
848,
24,
738
]
],
[
[
443,
23,
126
],
[
126,
2... | [
[
[
"Spironolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Spironolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
],
... | Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ib... |
DB00262 | DB08908 | 552 | 713 | [
"DDInter302",
"DDInter564"
] | Carmustine | Dimethyl fumarate | A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogen... | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Moderate | 1 | [
[
[
552,
24,
713
]
],
[
[
552,
24,
996
],
[
996,
24,
713
]
],
[
[
552,
24,
270
],
[
270,
63,
713
]
],
[
[
552,
63,
1560
],
[
1560,
2... | [
[
[
"Carmustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Carmustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bedaquiline"
],
... | Carmustine may cause a moderate interaction that could exacerbate diseases when taken with Bedaquiline and Bedaquiline may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Carmustine may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab ... |
DB00661 | DB01041 | 122 | 770 | [
"DDInter1928",
"DDInter1789"
] | Verapamil | Thalidomide | Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
122,
24,
770
]
],
[
[
122,
6,
7524
],
[
7524,
45,
770
]
],
[
[
122,
18,
3106
],
[
3106,
57,
770
]
],
[
[
122,
21,
28789
],
[
28789,
... | [
[
[
"Verapamil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Verapamil",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)",
... | Verapamil (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Thalidomide (Compound)
Verapamil (Compound) downregulates DNAJA3 (Gene) and DNAJA3 (Gene) is downregulated by Thalidomide (Compound)
Verapamil (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by... |
DB00001 | DB01050 | 1,578 | 848 | [
"DDInter1037",
"DDInter900"
] | Lepirudin | Ibuprofen | Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor.[L41539,L41569] Natural hirudin is an endogenous anticoagulant found in _Hirudo medicinalis_ leeches. Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence o... | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Moderate | 1 | [
[
[
1578,
24,
848
]
],
[
[
1578,
23,
297
],
[
297,
62,
848
]
],
[
[
1578,
24,
831
],
[
831,
24,
848
]
],
[
[
1578,
25,
1047
],
[
1047,
... | [
[
[
"Lepirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
]
],
[
[
"Lepirudin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clove... | Lepirudin may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Ibuprofen
Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Indomethacin and Indomethacin may caus... |
DB00030 | DB00215 | 1,685 | 1,230 | [
"DDInter934",
"DDInter388"
] | Insulin human | Citalopram | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Moderate | 1 | [
[
[
1685,
24,
1230
]
],
[
[
1685,
24,
318
],
[
318,
40,
1230
]
],
[
[
1685,
24,
168
],
[
168,
23,
1230
]
],
[
[
1685,
24,
629
],
[
629,
... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Citalopram"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Escitalopram"
],
... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Escitalopram and Escitalopram (Compound) resembles Citalopram (Compound)
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction tha... |
DB00196 | DB00762 | 600 | 613 | [
"DDInter743",
"DDInter973"
] | Fluconazole | Irinotecan | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Moderate | 1 | [
[
[
600,
24,
613
]
],
[
[
600,
6,
8374
],
[
8374,
45,
613
]
],
[
[
600,
7,
4603
],
[
4603,
46,
613
]
],
[
[
600,
7,
7885
],
[
7885,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Irinotecan"
]
],
[
[
"Fluconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Fluconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Irinotecan (Compound)
Fluconazole (Compound) upregulates RAB11FIP2 (Gene) and RAB11FIP2 (Gene) is upregulated by Irinotecan (Compound)
Fluconazole (Compound) upregulates MELK (Gene) and MELK (Gene) is downregulated by Irinotecan (Compound)
Flucona... |
DB00539 | DB14723 | 11 | 159 | [
"DDInter1837",
"DDInter1026"
] | Toremifene | Larotrectinib | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
11,
24,
159
]
],
[
[
11,
24,
479
],
[
479,
23,
159
]
],
[
[
11,
25,
318
],
[
318,
23,
159
]
],
[
[
11,
64,
1230
],
[
1230,
23,
... | [
[
[
"Toremifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Toremifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
],
[
... | Toremifene may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepezil may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Toremifene may lead to a major life threatening interaction when taken with Escitalopram and Escitalopram may cau... |
DB00985 | DB01409 | 1,443 | 1,415 | [
"DDInter562",
"DDInter1815"
] | Dimenhydrinate | Tiotropium | Dimehydrinate was first described in the literature in 1949, and patented in 1950. Early research into dimenhydrinate focused on its role as an antihistamine for urticaria; the treatment of motion sickness was an accidental discovery. Dimenhydrinate, also known as B-dimethylaminoethyl benzohydrol ether 8-chlorotheophyl... | Tiotropium is a long-acting, antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma.[A180163,L7084,L7087,L7090,L7093] Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and bronchodilation.[A180163,L7084,L... | Moderate | 1 | [
[
[
1443,
24,
1415
]
],
[
[
1443,
6,
4304
],
[
4304,
45,
1415
]
],
[
[
1443,
21,
28680
],
[
28680,
60,
1415
]
],
[
[
1443,
63,
1594
],
[
1... | [
[
[
"Dimenhydrinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tiotropium"
]
],
[
[
"Dimenhydrinate",
"{u} (Compound) binds {v} (Gene)",
"CHRM2"
],
[
"CHRM2",
"{u} (Gene) is bound by {v} (Compo... | Dimenhydrinate (Compound) binds CHRM2 (Gene) and CHRM2 (Gene) is bound by Tiotropium (Compound)
Dimenhydrinate (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Tiotropium (Compound)
Dimenhydrinate may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxy... |
DB00424 | DB00679 | 19 | 684 | [
"DDInter896",
"DDInter1796"
] | Hyoscyamine | Thioridazine | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Moderate | 1 | [
[
[
19,
24,
684
]
],
[
[
19,
24,
1237
],
[
1237,
40,
684
]
],
[
[
19,
24,
216
],
[
216,
1,
684
]
],
[
[
19,
63,
508
],
[
508,
1,
... | [
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thioridazine"
]
],
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
],
... | Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomipramine (Compound) resembles Thioridazine (Compound)
Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpromazine and Chlorpromazine (Compound) resembles Thiori... |
DB00877 | DB01229 | 629 | 973 | [
"DDInter1678",
"DDInter1377"
] | Sirolimus | Paclitaxel | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Moderate | 1 | [
[
[
629,
24,
973
]
],
[
[
629,
24,
310
],
[
310,
63,
973
]
],
[
[
629,
6,
7524
],
[
7524,
45,
973
]
],
[
[
629,
7,
9489
],
[
9489,
4... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Sirolimus (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Paclitaxel (Compound)
Sirolimus (Compoun... |
DB00938 | DB08865 | 455 | 1,593 | [
"DDInter1635",
"DDInter448"
] | Salmeterol | Crizotinib | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Moderate | 1 | [
[
[
455,
24,
1593
]
],
[
[
455,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
455,
7,
7260
],
[
7260,
46,
1593
]
],
[
[
455,
18,
3517
],
[
3517,
... | [
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
]
],
[
[
"Salmeterol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Salmeterol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Salmeterol (Compound) upregulates MVD (Gene) and MVD (Gene) is upregulated by Crizotinib (Compound)
Salmeterol (Compound) downregulates TXNRD1 (Gene) and TXNRD1 (Gene) is upregulated by Crizotinib (Compound)
Salmeterol (Compou... |
DB00515 | DB01265 | 589 | 1,477 | [
"DDInter387",
"DDInter1757"
] | Cisplatin | Telbivudine | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Telbivudine is a synthetic thymidine nucleoside analog with specific activity against the hepatitis B virus. Telbivudine is orally administered, with good tolerance, lack of toxicity and no dose-limiting side effects. | Moderate | 1 | [
[
[
589,
24,
1477
]
],
[
[
589,
63,
141
],
[
141,
1,
1477
]
],
[
[
589,
24,
231
],
[
231,
1,
1477
]
],
[
[
589,
21,
28745
],
[
28745,
... | [
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telbivudine"
]
],
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Floxuridine"
],
[
... | Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Floxuridine and Floxuridine (Compound) resembles Telbivudine (Compound)
Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Stavudine and Stavudine (Compound) resembles Telbivudine (Compound)
... |
DB00857 | DB01246 | 1,387 | 820 | [
"DDInter1768",
"DDInter45"
] | Terbinafine | Alimemazine | Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epox... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
1387,
24,
820
]
],
[
[
1387,
24,
104
],
[
104,
40,
820
]
],
[
[
1387,
24,
401
],
[
401,
24,
820
]
],
[
[
1387,
63,
146
],
[
146,
... | [
[
[
"Terbinafine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Terbinafine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
... | Terbinafine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (Compound)
Terbinafine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction... |
DB00572 | DB09488 | 85 | 103 | [
"DDInter136",
"DDInter23"
] | Atropine | Acrivastine | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Acrivastine is a triprolidine analog antihistamine indicated for the treatment of allergies and hay fever. As an H1 receptor antagonist, it functions by blocking the action of histamine at this receptor thereby preventing the symptoms associated with histamine release such as pruritis, vasodilation, hypotension, edema,... | Moderate | 1 | [
[
[
85,
24,
103
]
],
[
[
85,
24,
1405
],
[
1405,
24,
103
]
],
[
[
85,
63,
194
],
[
194,
24,
103
]
],
[
[
85,
23,
551
],
[
551,
24,
... | [
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acrivastine"
]
],
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclobenzaprine"
],
[
... | Atropine may cause a moderate interaction that could exacerbate diseases when taken with Cyclobenzaprine and Cyclobenzaprine may cause a moderate interaction that could exacerbate diseases when taken with Acrivastine
Atropine may cause a moderate interaction that could exacerbate diseases when taken with Darifenacin an... |
DB00827 | DB01177 | 646 | 77 | [
"DDInter383",
"DDInter904"
] | Cinoxacin | Idarubicin | Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections. | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Minor | 0 | [
[
[
646,
23,
77
]
],
[
[
646,
21,
28810
],
[
28810,
60,
77
]
],
[
[
646,
62,
896
],
[
896,
24,
77
]
],
[
[
646,
23,
995
],
[
995,
24... | [
[
[
"Cinoxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Idarubicin"
]
],
[
[
"Cinoxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Gastrointestinal pain"
],
[
"Gastrointestinal pain",
"{u} (... | Cinoxacin (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Idarubicin (Compound)
Cinoxacin may cause a minor interaction that can limit clinical effects when taken with Etoposide and Etoposide may cause a moderate interaction that could exacerbate diseases when ... |
DB00719 | DB09118 | 1,219 | 1,580 | [
"DDInter149",
"DDInter1711"
] | Azatadine | Stiripentol | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Moderate | 1 | [
[
[
1219,
24,
1580
]
],
[
[
1219,
24,
1532
],
[
1532,
24,
1580
]
],
[
[
1219,
24,
1609
],
[
1609,
63,
1580
]
],
[
[
1219,
63,
128
],
[
128... | [
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stiripentol"
]
],
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
],
[
... | Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol
Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine and Pent... |
DB00427 | DB11642 | 1,233 | 938 | [
"DDInter1879",
"DDInter1480"
] | Triprolidine | Pitolisant | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Moderate | 1 | [
[
[
1233,
24,
938
]
],
[
[
1233,
24,
820
],
[
820,
24,
938
]
],
[
[
1233,
63,
128
],
[
128,
24,
938
]
],
[
[
1233,
24,
820
],
[
820,
... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitolisant"
]
],
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
],
... | Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Pitolisant
Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniram... |
DB00911 | DB08901 | 458 | 1,468 | [
"DDInter1811",
"DDInter1492"
] | Tinidazole | Ponatinib | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
458,
24,
1468
]
],
[
[
458,
24,
478
],
[
478,
24,
1468
]
],
[
[
458,
6,
8374
],
[
8374,
45,
1468
]
],
[
[
458,
21,
28852
],
[
28852,
... | [
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
... | Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Tinidazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ponatinib (Compound)
Tinidazole (Compound) ... |
DB09100 | DB09146 | 320 | 489 | [
"DDInter1799",
"DDInter978"
] | Thyroid, porcine | Iron sucrose | Thyroid extract is dried and powdered thyroid glands from pigs containing tiiodothyronine (T3) and thyroxine (T4) used to supplement low or absent thyroid activity.[A190831,L11755] Thyroid extract has been described in literature to treat hypothyroidism since 1891 but its use dates back as far as the 6th century. Thyro... | Iron sucrose (sucroferric oxyhydroxide or iron saccharate) is used as a source of iron in patients with iron deficiency anemia with chronic kidney disease (CKD), including those who are undergoing dialysis (hemodialysis or peritoneal) and those who do not require dialysis. Due to less side effects than iron dextran, ir... | Moderate | 1 | [
[
[
320,
24,
489
]
],
[
[
320,
63,
1596
],
[
1596,
24,
489
]
],
[
[
320,
24,
428
],
[
428,
63,
489
]
],
[
[
320,
63,
1596
],
[
1596,
... | [
[
[
"Thyroid, porcine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron sucrose"
]
],
[
[
"Thyroid, porcine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron"
],
... | Thyroid, porcine may cause a moderate interaction that could exacerbate diseases when taken with Iron and Iron may cause a moderate interaction that could exacerbate diseases when taken with Iron sucrose
Thyroid, porcine may cause a moderate interaction that could exacerbate diseases when taken with Ferrous fumarate an... |
DB00204 | DB01177 | 228 | 77 | [
"DDInter580",
"DDInter904"
] | Dofetilide | Idarubicin | Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter. | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Major | 2 | [
[
[
228,
25,
77
]
],
[
[
228,
18,
6448
],
[
6448,
46,
77
]
],
[
[
228,
18,
18226
],
[
18226,
57,
77
]
],
[
[
228,
21,
30335
],
[
30335,
... | [
[
[
"Dofetilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idarubicin"
]
],
[
[
"Dofetilide",
"{u} (Compound) downregulates {v} (Gene)",
"CTSD"
],
[
"CTSD",
"{u} (Gene) is upregulated by {v} (Compound)",
... | Dofetilide (Compound) downregulates CTSD (Gene) and CTSD (Gene) is upregulated by Idarubicin (Compound)
Dofetilide (Compound) downregulates GDF15 (Gene) and GDF15 (Gene) is downregulated by Idarubicin (Compound)
Dofetilide (Compound) causes Bundle branch block (Side Effect) and Bundle branch block (Side Effect) is caus... |
DB00604 | DB12825 | 1,425 | 1,375 | [
"DDInter385",
"DDInter1032"
] | Cisapride | Lefamulin | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Major | 2 | [
[
[
1425,
25,
1375
]
],
[
[
1425,
23,
112
],
[
112,
23,
1375
]
],
[
[
1425,
24,
159
],
[
159,
63,
1375
]
],
[
[
1425,
63,
1101
],
[
1101,
... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lefamulin"
]
],
[
[
"Cisapride",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidazol... | Cisapride may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lefamulin
Cisapride may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Laro... |
DB00196 | DB11581 | 600 | 1,456 | [
"DDInter743",
"DDInter1926"
] | Fluconazole | Venetoclax | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Major | 2 | [
[
[
600,
25,
1456
]
],
[
[
600,
25,
1135
],
[
1135,
23,
1456
]
],
[
[
600,
25,
1476
],
[
1476,
63,
1456
]
],
[
[
600,
24,
230
],
[
230,
... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Venetoclax"
]
],
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} m... | Fluconazole may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Venetoclax
Fluconazole may lead to a major life threatening interaction when taken with Brigatinib and Brigatinib may cause a moderate intera... |
DB00738 | DB11988 | 485 | 270 | [
"DDInter1420",
"DDInter1321"
] | Pentamidine | Ocrelizumab | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
485,
24,
270
]
],
[
[
485,
24,
1491
],
[
1491,
24,
270
]
],
[
[
485,
63,
1555
],
[
1555,
24,
270
]
],
[
[
485,
64,
1101
],
[
1101,
... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
],
... | Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin and Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and ... |
DB00514 | DB01182 | 506 | 371 | [
"DDInter527",
"DDInter1534"
] | Dextromethorphan | Propafenone | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. | Moderate | 1 | [
[
[
506,
24,
371
]
],
[
[
506,
24,
271
],
[
271,
1,
371
]
],
[
[
506,
24,
675
],
[
675,
40,
371
]
],
[
[
506,
6,
6017
],
[
6017,
45,... | [
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propafenone"
]
],
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mirabegron"
... | Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Mirabegron and Mirabegron (Compound) resembles Propafenone (Compound)
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Dextropropoxyphene and Dextropropoxyphene (Compound) res... |
DB00001 | DB00554 | 1,578 | 1,027 | [
"DDInter1037",
"DDInter1478"
] | Lepirudin | Piroxicam | Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor.[L41539,L41569] Natural hirudin is an endogenous anticoagulant found in _Hirudo medicinalis_ leeches. Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence o... | A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. | Moderate | 1 | [
[
[
1578,
24,
1027
]
],
[
[
1578,
24,
1171
],
[
1171,
1,
1027
]
],
[
[
1578,
24,
222
],
[
222,
63,
1027
]
],
[
[
1578,
24,
1061
],
[
1061,... | [
[
[
"Lepirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Piroxicam"
]
],
[
[
"Lepirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meloxicam"
],
[
... | Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Meloxicam and Meloxicam (Compound) resembles Piroxicam (Compound)
Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could ex... |
DB00682 | DB01607 | 126 | 1,390 | [
"DDInter1951",
"DDInter1803"
] | Warfarin | Ticarcillin | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | An antibiotic derived from penicillin similar to carbenicillin in action. | Moderate | 1 | [
[
[
126,
24,
1390
]
],
[
[
126,
24,
514
],
[
514,
40,
1390
]
],
[
[
126,
24,
339
],
[
339,
1,
1390
]
],
[
[
126,
63,
790
],
[
790,
4... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticarcillin"
]
],
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzylpenicillin"
],
[... | Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Benzylpenicillin and Benzylpenicillin (Compound) resembles Ticarcillin (Compound)
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Bacampicillin and Bacampicillin (Compound) resembles Ticarci... |
DB00490 | DB01142 | 946 | 1,264 | [
"DDInter254",
"DDInter593"
] | Buspirone | Doxepin | Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class, buspirone is a serotonin 5-HT<sub>1A</sub> receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic dr... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Major | 2 | [
[
[
946,
25,
1264
]
],
[
[
946,
24,
401
],
[
401,
24,
1264
]
],
[
[
946,
63,
1594
],
[
1594,
24,
1264
]
],
[
[
946,
24,
649
],
[
649,
... | [
[
[
"Buspirone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Doxepin"
]
],
[
[
"Buspirone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
"Promethazine"... | Buspirone may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Buspirone may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylam... |
DB00451 | DB09564 | 542 | 1,296 | [
"DDInter1064",
"DDInter930"
] | Levothyroxine | Insulin degludec | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
542,
24,
1296
]
],
[
[
542,
23,
17
],
[
17,
24,
1296
]
],
[
[
542,
24,
1411
],
[
1411,
24,
1296
]
],
[
[
542,
63,
1645
],
[
1645,
... | [
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Levothyroxine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sotalol"
],
... | Levothyroxine may cause a minor interaction that can limit clinical effects when taken with Sotalol and Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and T... |
DB00470 | DB12825 | 530 | 1,375 | [
"DDInter601",
"DDInter1032"
] | Dronabinol | Lefamulin | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Moderate | 1 | [
[
[
530,
24,
1375
]
],
[
[
530,
24,
159
],
[
159,
63,
1375
]
],
[
[
530,
24,
1532
],
[
1532,
24,
1375
]
],
[
[
530,
63,
254
],
[
254,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
[
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and I... |
DB00877 | DB09133 | 629 | 1,527 | [
"DDInter1678",
"DDInter965"
] | Sirolimus | Iothalamic acid | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent. | Major | 2 | [
[
[
629,
25,
1527
]
],
[
[
629,
24,
762
],
[
762,
24,
1527
]
],
[
[
629,
63,
84
],
[
84,
24,
1527
]
],
[
[
629,
24,
242
],
[
242,
63... | [
[
[
"Sirolimus",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iothalamic acid"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bepridil"
],
[
"Bepridil"... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Bepridil and Bepridil may cause a moderate interaction that could exacerbate diseases when taken with Iothalamic acid
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Nisoldipine and Nisold... |
DB01174 | DB09143 | 697 | 313 | [
"DDInter1442",
"DDInter1701"
] | Phenobarbital | Sonidegib | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) developed as an anticancer agent by Novartis. It was FDA approved in 2015 for the treatment of basal cell carcinoma. | Major | 2 | [
[
[
697,
25,
313
]
],
[
[
697,
62,
660
],
[
660,
23,
313
]
],
[
[
697,
25,
478
],
[
478,
24,
313
]
],
[
[
697,
63,
597
],
[
597,
24,... | [
[
[
"Phenobarbital",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sonidegib"
]
],
[
[
"Phenobarbital",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Esomeprazole"
],
[
"Esome... | Phenobarbital may cause a minor interaction that can limit clinical effects when taken with Esomeprazole and Esomeprazole may cause a minor interaction that can limit clinical effects when taken with Sonidegib
Phenobarbital may lead to a major life threatening interaction when taken with Nilotinib and Nilotinib may cau... |
DB05316 | DB06589 | 749 | 1,250 | [
"DDInter1467",
"DDInter1400"
] | Pimavanserin | Pazopanib | Pimavanserin is an atypical antipsychotic indicated for the treatment of psychiatric disorders. Although the exact mechanism of action is unknown, it is thought that pimavanserin interacts with the serotonin receptors, particularly the 5-HT<sub>2A</sub> and HT<sub>2C</sub> receptors. Unlike other atypical antipsychotic... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
749,
24,
1250
]
],
[
[
749,
62,
112
],
[
112,
23,
1250
]
],
[
[
749,
63,
1151
],
[
1151,
24,
1250
]
],
[
[
749,
24,
28
],
[
28,
... | [
[
[
"Pimavanserin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Pimavanserin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Pimavanserin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pazopanib
Pimavanserin may cause a moderate interaction that could exacerbate diseases when taken with Sunitinib and Su... |
DB09343 | DB12332 | 750 | 1,619 | [
"DDInter1816",
"DDInter1626"
] | Tipiracil | Rucaparib | Tipiracil is a thymidine phosphorylase inhibitor. It is used in combination with trifluridine, in a ratio of 1:0.5, to form TAS-102. The main function of Tipiracil in TAS-102 is to increase trifluridine bioavailability by inhibiting its catabolism. TAS-102 is indicated for the treatment of metastatic colorectal cancer ... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
750,
24,
1619
]
],
[
[
750,
24,
1476
],
[
1476,
24,
1619
]
],
[
[
750,
63,
1228
],
[
1228,
24,
1619
]
],
[
[
750,
63,
1593
],
[
1593,
... | [
[
[
"Tipiracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Tipiracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
],
[
... | Tipiracil may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib
Tipiracil may cause a moderate interaction that could exacerbate diseases when taken with Lenvatinib and Lenvatini... |
DB00334 | DB00747 | 867 | 1,442 | [
"DDInter1326",
"DDInter1647"
] | Olanzapine | Scopolamine | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | Moderate | 1 | [
[
[
867,
24,
1442
]
],
[
[
867,
24,
19
],
[
19,
24,
1442
]
],
[
[
867,
63,
1089
],
[
1089,
24,
1442
]
],
[
[
867,
6,
7420
],
[
7420,
... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Scopolamine"
]
],
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
[
... | Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Scopolamine
Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Ipratropium and Ip... |
DB00397 | DB01278 | 1,466 | 1,021 | [
"DDInter1458",
"DDInter1506"
] | Phenylpropanolamine | Pramlintide | Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Moderate | 1 | [
[
[
1466,
24,
1021
]
],
[
[
1466,
24,
9
],
[
9,
63,
1021
]
],
[
[
1466,
35,
22
],
[
22,
63,
1021
]
],
[
[
1466,
24,
1144
],
[
1144,
... | [
[
[
"Phenylpropanolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pramlintide"
]
],
[
[
"Phenylpropanolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotri... | Phenylpropanolamine may cause a moderate interaction that could exacerbate diseases when taken with Methotrimeprazine and Methotrimeprazine may cause a moderate interaction that could exacerbate diseases when taken with Pramlintide
Phenylpropanolamine (Compound) resembles Ephedrine (Compound) and Phenylpropanolamine ma... |
DB00880 | DB00959 | 359 | 1,486 | [
"DDInter360",
"DDInter1191"
] | Chlorothiazide | Methylprednisolone | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Moderate | 1 | [
[
[
359,
24,
1486
]
],
[
[
359,
63,
175
],
[
175,
40,
1486
]
],
[
[
359,
63,
167
],
[
167,
1,
1486
]
],
[
[
359,
24,
1220
],
[
1220,
... | [
[
[
"Chlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Chlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolo... | Chlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Chlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) re... |
DB01222 | DB08873 | 617 | 74 | [
"DDInter246",
"DDInter221"
] | Budesonide | Boceprevir | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Boceprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in... | Major | 2 | [
[
[
617,
25,
74
]
],
[
[
617,
6,
8374
],
[
8374,
45,
74
]
],
[
[
617,
21,
28769
],
[
28769,
60,
74
]
],
[
[
617,
63,
86
],
[
86,
24,... | [
[
[
"Budesonide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Boceprevir"
]
],
[
[
"Budesonide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Bocepre... | Budesonide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Boceprevir (Compound)
Budesonide (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Boceprevir (Compound)
Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Micon... |
DB00352 | DB06643 | 482 | 1,136 | [
"DDInter1814",
"DDInter500"
] | Tioguanine | Denosumab | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL inhibitor approved to prevent osteoclast-mediated bone loss.... | Moderate | 1 | [
[
[
482,
24,
1136
]
],
[
[
482,
24,
1555
],
[
1555,
24,
1136
]
],
[
[
482,
63,
1648
],
[
1648,
24,
1136
]
],
[
[
482,
24,
1480
],
[
1480,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Denosumab"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin"
],
[
... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Denosumab
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Alde... |
DB00960 | DB09080 | 887 | 144 | [
"DDInter1471",
"DDInter1331"
] | Pindolol | Olodaterol | Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the earl... | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Major | 2 | [
[
[
887,
25,
144
]
],
[
[
887,
25,
1011
],
[
1011,
24,
144
]
],
[
[
887,
63,
1445
],
[
1445,
24,
144
]
],
[
[
887,
24,
1264
],
[
1264,
... | [
[
[
"Pindolol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Olodaterol"
]
],
[
[
"Pindolol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
],
[
"Fingolimod",
"{u} may c... | Pindolol may lead to a major life threatening interaction when taken with Fingolimod and Fingolimod may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Pindolol may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine and Pseudoephedrine may ... |
DB00046 | DB01277 | 1,179 | 1,022 | [
"DDInter940",
"DDInter1131"
] | Insulin lispro | Mecasermin | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Mecasermin contains recombinant-DNA-engineered human insulin-like growth factor-1 (rhIGF-1)[FDA Label]. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges and a molecular weight of 7649 daltons. The amino acid sequence of the product is identical to that of endogenous human I... | Moderate | 1 | [
[
[
1179,
24,
1022
]
],
[
[
1179,
24,
1411
],
[
1411,
24,
1022
]
],
[
[
1179,
24,
877
],
[
877,
63,
1022
]
],
[
[
1179,
24,
1411
],
[
1411... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mecasermin"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
],... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Mecasermin
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Macimorelin... |
DB00515 | DB04865 | 589 | 4 | [
"DDInter387",
"DDInter1335"
] | Cisplatin | Omacetaxine mepesuccinate | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
589,
24,
4
]
],
[
[
589,
6,
7720
],
[
7720,
46,
4
]
],
[
[
589,
25,
770
],
[
770,
24,
4
]
],
[
[
589,
24,
496
],
[
496,
63,
... | [
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Cisplatin",
"{u} (Compound) binds {v} (Gene)",
"PTGS2"
],
[
"PTGS2",
"{u} (Gene) is upregulated by... | Cisplatin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Cisplatin may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate... |
DB00694 | DB08904 | 51 | 375 | [
"DDInter485",
"DDInter342"
] | Daunorubicin | Certolizumab pegol | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Major | 2 | [
[
[
51,
25,
375
]
],
[
[
51,
63,
1461
],
[
1461,
23,
375
]
],
[
[
51,
24,
200
],
[
200,
63,
375
]
],
[
[
51,
25,
1593
],
[
1593,
24,... | [
[
[
"Daunorubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Certolizumab pegol
Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Candida albic... |
DB09268 | DB13179 | 1,662 | 68 | [
"DDInter1464",
"DDInter1882"
] | Picosulfuric acid | Troleandomycin | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | A macrolide antibiotic that is similar to erythromycin. | Moderate | 1 | [
[
[
1662,
24,
68
]
],
[
[
1662,
63,
319
],
[
319,
23,
68
]
],
[
[
1662,
63,
251
],
[
251,
24,
68
]
],
[
[
1662,
24,
1619
],
[
1619,
... | [
[
[
"Picosulfuric acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troleandomycin"
]
],
[
[
"Picosulfuric acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amoxicill... | Picosulfuric acid may cause a moderate interaction that could exacerbate diseases when taken with Amoxicillin and Amoxicillin may cause a minor interaction that can limit clinical effects when taken with Troleandomycin
Picosulfuric acid may cause a moderate interaction that could exacerbate diseases when taken with Bet... |
DB00087 | DB00495 | 599 | 139 | [
"DDInter41",
"DDInter1961"
] | Alemtuzumab | Zidovudine | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain... | Moderate | 1 | [
[
[
599,
24,
139
]
],
[
[
599,
24,
1083
],
[
1083,
24,
139
]
],
[
[
599,
24,
309
],
[
309,
63,
139
]
],
[
[
599,
63,
669
],
[
669,
2... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zidovudine"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluridine"
],
... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Trifluridine and Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and... |
DB00308 | DB08865 | 347 | 1,593 | [
"DDInter901",
"DDInter448"
] | Ibutilide | Crizotinib | Ibutilide is a Class III antiarrhythmic agent available in intravenous formulations. It is indicated for the conversion of acute atrial flutter and recent onset atrial fibrillation to normal sinus rhythm (NSR). | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Major | 2 | [
[
[
347,
25,
1593
]
],
[
[
347,
21,
28921
],
[
28921,
60,
1593
]
],
[
[
347,
24,
286
],
[
286,
63,
1593
]
],
[
[
347,
24,
455
],
[
455,
... | [
[
[
"Ibutilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
]
],
[
[
"Ibutilide",
"{u} (Compound) causes {v} (Side Effect)",
"Dizziness"
],
[
"Dizziness",
"{u} (Side Effect) is caused by {v} (Compou... | Ibutilide (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Crizotinib (Compound)
Ibutilide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide and Magnesium hydroxide may cause a moderate interaction that could exacerbate diseases when ta... |
DB00731 | DB01319 | 1,144 | 34 | [
"DDInter1269",
"DDInter777"
] | Nateglinide | Fosamprenavir | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Moderate | 1 | [
[
[
1144,
24,
34
]
],
[
[
1144,
63,
1091
],
[
1091,
40,
34
]
],
[
[
1144,
6,
8374
],
[
8374,
45,
34
]
],
[
[
1144,
21,
28723
],
[
28723,
... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosamprenavir"
]
],
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amprenavir"
],
... | Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Amprenavir and Amprenavir (Compound) resembles Fosamprenavir (Compound)
Nateglinide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fosamprenavir (Compound)
Nateglinide (Compound) causes Malnutrition (Side Effect) a... |
DB00445 | DB11986 | 322 | 484 | [
"DDInter655",
"DDInter648"
] | Epirubicin | Entrectinib | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
322,
24,
484
]
],
[
[
322,
23,
1247
],
[
1247,
23,
484
]
],
[
[
322,
24,
1539
],
[
1539,
24,
484
]
],
[
[
322,
23,
739
],
[
739,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Epirubicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Epirubicin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Ofloxacin an... |
DB00526 | DB11796 | 1,555 | 1,612 | [
"DDInter1355",
"DDInter786"
] | Oxaliplatin | Fostemsavir | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor. It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir prevents the first step in the... | Moderate | 1 | [
[
[
1555,
24,
1612
]
],
[
[
1555,
24,
112
],
[
112,
23,
1612
]
],
[
[
1555,
63,
1424
],
[
1424,
24,
1612
]
],
[
[
1555,
24,
823
],
[
823,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Fostemsavir
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Qu... |
DB00295 | DB00379 | 475 | 143 | [
"DDInter1244",
"DDInter1206"
] | Morphine | Mexiletine | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Antiarrhythmic agent pharmacologically similar to lidocaine. It may have some anticonvulsant properties. | Moderate | 1 | [
[
[
475,
24,
143
]
],
[
[
475,
6,
8374
],
[
8374,
45,
143
]
],
[
[
475,
21,
28784
],
[
28784,
60,
143
]
],
[
[
475,
24,
1503
],
[
1503,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mexiletine"
]
],
[
[
"Morphine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Morphine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Mexiletine (Compound)
Morphine (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Mexiletine (Compound)
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Lindane and... |
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