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15180068 | Characterizing uptake kinetics of PAHs from the air using polyethylene-based passive air samplers of multiple surface area-to-volume ratios. | Polyethylene passive sampling devices (PSDs) were deployed to investigate how passive samplers of multiple surface area-to-volume ratios could be used to characterize uptake kinetics for polyaromatic hydrocarbons (PAHs). Theoretically, uptake profiles for different thickness PSDs of the same surface area should show th... | [
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"Air Pollutants",
"Environmental Monitoring",
"Kinetics",
"Models, Theoretical",
"Molecular Weight",
"Polycyclic Aromatic Hydrocarbons",
"Reproducibility of Results"
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18817021 | Correlation of clinical data, anatomical site and disease stage in colorectal cancer. | OBJECTIVE: To evaluate the colorectal cancer clinical data with respect to the anatomical location and stage of disease.DESIGN: Retrospective observational study.SETTING: Kenyatta National Hospital (KNH), Nairobi, Kenya.SUBJECTS: Two hundred and fifty three tumours were categorised as right colonic (RCC), left colonic ... | [
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"Kenya",
"Middle Aged",
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17005011 | The genetics and genomics of the drought response in Populus. | The genetic nature of tree adaptation to drought stress was examined by utilizing variation in the drought response of a full-sib second generation (F(2)) mapping population from a cross between Populus trichocarpa (93-968) and P. deltoides Bart (ILL-129) and known to be highly divergent for a vast range of phenotypic ... | [
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"Disasters",
"Expressed Sequence Tags",
"Genome, Plant",
"Populus",
"Quantitative Trait Loci",
"RNA, Messenger",
"Species Specificity"
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15869213 | Making sausage--effective management of enterprise-wide clinical IT projects. | Unlike most other industries in which company employees are, well, company employees, U.S. hospitals are typically run by both employees (nurses, technicians, and administrative staff) and independent entrepreneurs (physicians and nurse practitioners). Therefore, major enterprise-wide clinical IT projects can never sim... | [
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"Diffusion of Innovation",
"Efficiency, Organizational",
"Hospital Information Systems",
"Organizational Objectives",
"United States"
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9862054 | Descriptive epidemiology of vulvar and vaginal cancers in Vaud, Switzerland, 1974-1994. | BACKGROUND: To analyse trends in incidence, survival and risk of second neoplasms following vaginal and vulvar cancers using data collected by the Swiss Cancer Registry of Vaud over the 21-year period 1974-1994.MATERIALS AND METHODS: Subjects were 257 vulvo-vaginal cancers. Of these, 69 were vaginal, 153 vulvar cancers... | [
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"Survival Analysis",
"Switzerland",
"Vaginal Neoplasms",
"Vulvar Neoplasms"
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10228166 | Cohabitation of insulators and silencing elements in yeast subtelomeric regions. | In budding yeast, the telomeric DNA is flanked by a combination of two subtelomeric repetitive sequences, the X and Y' elements. We have investigated the influence of these sequences on telomeric silencing. The telomere-proximal portion of either X or Y' dampened silencing when located between the telomere and the repo... | [
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2919819 | Electron microscopic study of the unique features and structural-morphologic relationship of canine bone marrow. | Electron microscopy revealed several unique features in canine bone marrow, compared with that of other species. The marrow was fatty and extensively trabeculated and was enclosed by a complete layer of endosteal bone-lining cells. Branched reticular cells were closely associated with each other and, occasionally, cove... | [
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28115117 | Mucin-like protein, a saliva component involved in brown planthopper virulence and host adaptation. | The rice brown planthopper (BPH), Nilaparvata lugens, can rapidly adapt to new resistant rice varieties within several generations, rendering its management burdensome. However, the molecular mechanism underlying its adaptability remains unclear. In this study, we investigated the potential role of mucin-like protein (... | [
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24497400 | 'Learning to live with OCD is a little mantra I often repeat': understanding the lived experience of obsessive-compulsive disorder (OCD) in the contemporary therapeutic context. | OBJECTIVES: While there has been an abundance of quantitative studies that examine the clinical features and treatment modalities of obsessive-compulsive disorder (OCD), only a few qualitative research studies examining the experience of OCD have been documented. Our objectives were to explore and understand psychosoci... | [
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31974625 | Hexavalent chromium intoxication induces intrinsic and extrinsic apoptosis in human renal cells. | Hexavalent chromium [Cr(VI)], is a well‑known toxic form of the heavy metal chromium in the natural environment. Clinical evidence has indicated that exposure to Cr(VI) can cause severe renal damage. The production of reactive oxygen species (ROS) due to intracellular reduction of Cr(VI) is the main mechanism underlyin... | [
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1945004 | [Determination of lymphocyte subpopulations, defined with monoclonal antibodies, in patients with iron deficiency anemia]. | Lymphocytary subpopulations have been determined, by means of monoclonal antibodies, in 24 patients afflicted with iron deficient anaemia, repeating the determination in 15 of the patients after an adequate iron therapy. In iron deficient patients a significant reduction of the percentage of lymphocytes T (OKT3+) has b... | [
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8873049 | Allogeneic murine melanoma cell vaccine: a model for the development of human allogeneic cancer vaccine. | In an attempt to induce an immune response against tumour antigens, several groups are transfecting cytokine and other genes into autologous tumour cells which are given to the patient as a vaccine. This process is labour-intensive, time-consuming and expensive. Allogeneic cells would offer a more convenient vehicle fo... | [
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"Histocompatibility Antigens Class I",
"Histocompatibility Antigens Class II",
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"Mice",
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17676819 | Density-based diamagnetic separation: devices for detecting binding events and for collecting unlabeled diamagnetic particles in paramagnetic solutions. | This paper describes the fabrication of a fluidic device for detecting and separating diamagnetic materials that differ in density. The basis for the separation is the balance of the magnetic and gravitational forces on diamagnetic materials suspended in a paramagnetic medium. The paper demonstrates two applications of... | [
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1953013 | Cognitive function after two doses of cranial irradiation for acute lymphoblastic leukaemia. | The cognitive function of 23 children given cranial irradiation in a dose of 24 Gy was compared with that of 41 given 18 Gy. No significant differences were found in intellectual function or in mean number of intelligence quotient points lost between patients in the two treatment groups. A reduction in the dose of cran... | [
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"Precursor Cell Lymphoblastic Leukemia-Lymphoma",
"Radiotherapy Dosage"
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28281181 | Characterization of Non-Infectious Virus-Like Particle Surrogates for Viral Clearance Applications. | Viral clearance is a critical aspect of biopharmaceutical manufacturing process validation. To determine the viral clearance efficacy of downstream chromatography and filtration steps, live viral "spiking" studies are conducted with model mammalian viruses such as minute virus of mice (MVM). However, due to biosafety c... | [
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21394968 | [The diagnostics of tapetoretinal dystrophies using electrophysiological methods]. | PURPOSE: The purpose of our study was to determine the diagnostic criteria of hereditary tapetoretinal dystrophies. In time of ten years we have followed the course of the disease, the manifestation and the change of the electrophysiological parameters in investigated patients.MATERIAL AND METHODS: At Dept. of Paediatr... | [
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11535682 | Persistent TTX-resistant Na+ current affects resting potential and response to depolarization in simulated spinal sensory neurons. | Small dorsal root ganglion (DRG) neurons, which include nociceptors, express multiple voltage-gated sodium currents. In addition to a classical fast inactivating tetrodotoxin-sensitive (TTX-S) sodium current, many of these cells express a TTX-resistant (TTX-R) sodium current that activates near -70 mV and is persistent... | [
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11068326 | Radiofrequency ablation of the kidney: acute and chronic histology in porcine model. | OBJECTIVES: To our knowledge, the chronic histopathologic effects of radiofrequency ablation (RFA) of renal parenchyma have not been extensively documented. In this study, we report the light and electron microscopic features of renal RFA in acute and chronic porcine models.METHODS: Eleven animals underwent renal RFA o... | [
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19945247 | [Carotid dissection during angioplasty for vasospasm induced by subarachnoid haemorrhage. The use of multimodal cerebral monitoring]. | We report the case of a 54-year-old woman presenting subarachnoid haemorrhage. She experienced multiple vasospasms and treatment included triple-H (hypervolaemia, hypertension, and haemodilution) and endovascular therapies. Right internal carotid dissection complicated angioplasty of the right middle cerebral artery. C... | [
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"Middle Aged",
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22522147 | Enhancing informed consent best practices: gaining patient, family and provider perspectives using reverse simulation. | BACKGROUND: Obtaining informed consent in the clinical setting is an important yet challenging aspect of providing safe and collaborative care to patients. While the medical profession has defined best practices for obtaining informed consent, it is unclear whether these standards meet the expressed needs of patients, ... | [
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19164838 | Especial skills: specificity embedded within generality. | Recent evidence suggests that massive amounts of practice of the basketball free throw (a "set shot") results in the development of a specific memory representation that is unique to this one shot distance and angle, and that is distinct from set shots taken at locations other than the free throw line. We termed this u... | [
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10856678 | Activity of poloxamer CRL-1072 against drug-sensitive and resistant strains of Mycobacterium tuberculosis in macrophages and in mice. | The present experiments evaluated a new, highly refined poloxamer, CRL-1072, alone and in combination with antibiotics against drug-sensitive and -resistant organisms. In macrophage culture, CRL-1072 reduced the drug concentration inhibiting 99% of control growth of isoniazid (INH) from 10 to 0.15 mg/l (fractional inhi... | [
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10869047 | Mitochondrial DNA abnormalities in skeletal muscle of patients with sporadic amyotrophic lateral sclerosis. | Amyotrophic lateral sclerosis is a neurodegenerative disease affecting the anterior horn cells of the spinal cord and cortical motor neurons. Previous findings have suggested a specific impairment of mitochondrial function in skeletal muscle of at least a limited number of patients. Applying flavoprotein/NAD(P)H autofl... | [
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10402151 | Health-related service utilization and HIV risk behaviors among HIV infected injection drug users and crack smokers. | This study was designed to assess utilization of health-related services and HIV risk related behaviors by HIV infected drug users one year prior to and two years following the availability of Ryan White Title I funding. Using a cross-sectional design, a total of 777 drug injectors and crack smokers from five US cities... | [
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24398930 | Nuclear localization signals of varicella zoster virus ORF4. | The varicella zoster virus (VZV) ORF4 protein, one of immediate-early genes protein, is associated with the tegument in purified virions. ORF4 protein functions at both transcriptional and post-transcriptional levels, present during different phase of whole VZV life cycle. ORF4 protein acts as a nucleocytoplasm shuttle... | [
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3486116 | Cellular uptake of 3,5,3'-triiodothyronine and thyroxine by red blood and thymus cells. | During recent studies of receptor binding of T3 and T4 in tadpole red blood cells (RBCs), it was found that the fractional uptake of T3 was 3-5 times greater than that of T4. The present studies were performed to determine if this difference was due to facilitated uptake of T3. All studies were performed in cells incub... | [
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15220333 | Regulation of unsaturated fatty acid biosynthesis in Saccharomyces: the endoplasmic reticulum membrane protein, Mga2p, a transcription activator of the OLE1 gene, regulates the stability of the OLE1 mRNA through exosome-mediated mechanisms. | The Saccharomyces cerevisiae OLE1 gene encodes a membrane-bound Delta9 fatty-acid desaturase, whose expression is regulated through transcriptional and mRNA stability controls. In wild type cells grown on fatty acid-free medium, OLE1 mRNA has a half-life of 10 +/- 1.5 min (basal stability) that becomes highly unstable ... | [
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3773008 | Traumatic carpal instability. | In general, two patterns of traumatic carpal instability can be discerned: palmar flexion intercalated segmental instability (PISI deformity) and dorsiflexion intercalated segmental instability (DISI deformity). Two case reports are described, demonstrating both types and their treatment. PISI deformity, seen less freq... | [
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31194241 | Biochemically Silent Sympathetic Paraganglioma, Pheochromocytoma, or Metastatic Disease in SDHD Mutation Carriers. | CONTEXT: Current guidelines do not consistently recommend imaging beyond the head and neck region in succinate dehydrogenase subunit D (SDHD) mutation carriers as long as catecholamine metabolite levels are within the reference range.PARTICIPANTS: We report a series of 10 patients carrying pathogenic variants in the SD... | [
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30251773 | Klotho protein supplementation reduces blood pressure and renal hypertrophy in db/db mice, a model of type 2 diabetes. | AIMS: Klotho interacts with various membrane proteins, such as receptors for transforming growth factor (TGF)-â and insulin-like growth factor (IGF), to alter their function. Renal expression of klotho is diminished in diabetes. The present study examined whether exogenous klotho protein supplementation ameliorates kid... | [
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12687881 | End tidal CO2 is a quantitative measure of cardiac arrest. | PURPOSE OF THE STUDY: Predictors of severity of cardiac arrest or efficacy of cardiopulmonary resuscitation are few. Respiratory end tidal CO2 (ETCO) is a marker of pulmonary blood flow and, possibly, cardiac arrest. The purpose of this study was to evaluate ETCO as a quantitative marker of cardiac arrest in a human mo... | [
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31126741 | Algorithm for the treatment of external nasal valve insufficiency. | INTRODUCTION: Nasal obstruction is one of the most prevalent complaints in the population. The main causes of nasal obstruction are inflammatory, infectious or anatomical alterations. Anatomical alterations include nasal septum deviation, turbinate hypertrophy, and nasal valve insufficiency (external and/or internal). ... | [
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17394534 | Effects of insulin vs. glibenclamide in recently diagnosed patients with type 2 diabetes: a 4-year follow-up. | AIM: To compare effects of early insulin vs. glibenclamide treatment on beta-cell function, metabolic control and quality of life (QL) in recently diagnosed patients with type 2 diabetes.METHODS: Forty-nine patients with type 2 diabetes diagnosed 0-2 years before inclusion were randomized to two daily injections of pre... | [
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339884 | [Experimental investigation on non-specific foreign body sarcoma induction of Al2O3-ceramic implants (author's transl)]. | This investigation presents experimental results on possible non-specific foreign body sarcoma induction by Al2O3-ceramic implants. Solid and porous discs, subcutaneously implanted in rats produce a sarcoma rate of 17.4 resp. 17.8 p.c. while roughly perforated discs initiate sarcomas at a rate of 25.4 p.c. These values... | [
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9580141 | Gluten sensitivity in patients with primary biliary cirrhosis. | OBJECTIVE: Whereas celiac disease and primary biliary cirrhosis have been reported to coexist in the same patient, the frequency of this relationship has not been clarified. Nowadays, the concept of celiac disease has been extended from that of a severe enteropathy to a broader concept of gluten-driven intestinal immun... | [
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3108204 | A new fixed cryosection technique for the simultaneous immunocytochemical demonstration of T6 and S100 antigens. | A formalin-calcium fixation method of preparing cryosections is described, which allows demonstration of Langerhans' cells by S100 antigen staining on frozen sections. The number of Langerhans' cells given by T6 antigen staining is also higher in formalin-calcium fixed frozen sections than acetone fixed frozen sections... | [
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18772248 | Effects of N2,N2-dimethylguanosine on RNA structure and stability: crystal structure of an RNA duplex with tandem m2 2G:A pairs. | Methylation of the exocyclic amino group of guanine is a relatively common modification in rRNA and tRNA. Single methylation (N(2)-methylguanosine, m(2)G) is the second most frequently encountered nucleoside analog in Escherichia coli rRNAs. The most prominent case of dual methylation (N(2),N(2)-dimethylguanosine, m(2)... | [
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28006811 | Seven new species of the genus <i>Xestoleberis</i> (Ostracoda: Podocopida: Cytheroidea) from the Fiji Archipelago. | The genus Xestoleberis has a global distribution, and although they are predominant in shallow marine environments adapted to both sediment and algal habitats, only two species of this genus, Xestoleberis curta (Brady, 1866) and Xestoleberis variegata Brady, 1880, have previously been reported from the Fiji archipelago... | [
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10071221 | Trifluoroleucine resistance and regulation of alpha-isopropyl malate synthase in Saccharomyces cerevisiae. | Seven spontaneous Saccharomyces cerevisiae mutants that express dominant resistance to 5,5,5-trifluoro-DL-leucine have been characterised at the molecular level. The gene responsible for the resistance was cloned from one of the mutants (FSC2.4). Determination of its nucleotide sequence showed that it was an allele of ... | [
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31715133 | Synergistic but not additive effect between ACPA and lithium in the dorsal hippocampal region on spatial learning and memory in rats: Isobolographic analyses. | Lithium and cannabinoids can disrupt learning and memory performance. The goal of the present study is to investigate the additive or synergistic effect of lithium and cannabinoid combination doses on spatial learning and memory in rats by isobolographic analyses. Although several studies have suggested synergistic eff... | [
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17498111 | The birth and development of sexual medicine: reflections of my personal journey. | INTRODUCTION: The phrase "sexual medicine" has become commonplace, as there is now the International Society for Sexual Medicine, the British Society for Sexual Medicine, the European Academy for Sexual Medicine, and the Journal of Sexual Medicine. The historic origin of the phrase "sexual medicine" is somewhat obscure... | [
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3585131 | A microcomputer implementation of status and alarm algorithms in a cardiac surgical intensive care unit. | Algorithms have been developed for monitoring the cardiovascular status of patients on their return to an intensive care unit after cardiac surgery and also for giving an immediate alarm of a critical deterioration in this status. The two systems for implementing these algorithms were initially developed on Z80 based m... | [
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22838165 | [Diagnostic relevance of fine needle aspiration cytology in nodular thyroid lesions]. | BACKGROUND/AIM: Fine needle aspiration cytology (FNAC) of the thyroid gland has been used as an initial investigative procedure of thyroid nodule(s) in the Department of Pathology at the Institute of Oncology of Vojvodina for more than 20 years. This procedure is rapid, inexpensive and technologically simple, yet it ha... | [
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"Middle Aged",
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"Sensitivity and Specificity",
"Thyroid Gland",
"Thyroid Neoplasms",
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] | {
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12687743 | Update on surgical simulation: the Ohio State University experience. | The authors discuss and review their experience with surgical simulation from early preoperative planning stations, to their involvement with functional endoscopic sinus surgery, to their current project. The future of such endeavors is discussed. | [
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18294447 | Surface plasmon resonance characterization of calspermin-calmodulin binding kinetics. | We cloned, expressed, and purified a chimeric fusion between a soluble green fluorescent protein (smGFP) and the calmodulin binding protein calspermin. We have shown that the fusion protein, labeled smGN, has a K(i) in the calmodulin-dependent cyclic nucleotide phosphodiesterase activity assay of 1.97 nM, i.e., 3800 ti... | [
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27403042 | Minimizing Ports During Robotic Partial Nephrectomy. | BACKGROUND AND OBJECTIVE: Robotic upper urinary tract surgery is in most of the cases performed utilizing a standard 5 port configuration. Fewer ports can potentially produce a less invasive operation. Taking in consideration the above we report a novel technique for robot assisted laparoscopic partial nephrectomy util... | [
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20937652 | Neonatal jaundice, autism, and other disorders of psychological development. | OBJECTIVES: The goals were to study the association between neonatal jaundice and disorders of psychological development in a national, population-based cohort and to study whether gestational age, parity, and season of birth influenced that association.METHODS: A population-based, follow-up study of all children born ... | [
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22099762 | Assessment of tissue-engineered islet graft viability by fluorine magnetic resonance spectroscopy. | INTRODUCTION: Despite significant progress in the last decade, islet transplantation remains an experimental therapy for a limited number of patients with type 1 diabetes. Tissue-engineered approaches may provide promising alternatives to the current clinical protocol and would benefit greatly from concurrent developme... | [
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12495790 | Gender differences in predictors of initiation, retention, and completion in an HMO-based substance abuse treatment program. | We studied gender differences in treatment process indicators among 293 HMO members recommended for substance abuse treatment. Treatment initiation, completion, and time spent in treatment did not differ by gender, but factors predicting these outcomes differed markedly. Initiation was predicted in women by alcohol dia... | [
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"Retention, Psychology",
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"United Sta... | {
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16504024 | Healing with animals in the Levant from the 10th to the 18th century. | Animals and products derived from different organs of their bodies have constituted part of the inventory of medicinal substances used in various cultures since ancient times. The article reviews the history of healing with animals in the Levant (The Land of Israel and parts of present-day Syria, Lebanon, and Jordan, d... | [
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"History, 15th Century",
"History, 16th Century",
"History, 17th Century",
"History, 18th Century",
"History, Medieval",
"Humans",
"Materia Medica",
"Medicine, Traditional",
"Middle East",
"Pharmacognosy"
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15946566 | [Mediastinal lymph nodes micro-metastases in patients with clinical stage I-II lung cancer]. | OBJECTIVE: To investigate micro-metastasis in mediastinal lymph nodes (mLN) of patients with clinical stage I approximately II lung cancer and its clinical significance.METHODS: A total of 181 mLN from 32 lung cancer patients in clinical stage I approximately II were collected during operation and their frozen sections... | [
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30511660 | Visually interpretable deep network for diagnosis of breast masses on mammograms. | Recently, deep learning technology has achieved various successes in medical image analysis studies including computer-aided diagnosis (CADx). However, current CADx approaches based on deep learning have a limitation in interpreting diagnostic decisions. The limited interpretability is a major challenge for practical u... | [
5079,
388,
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26801886 | Patterns of PD-L1 expression and CD8 T cell infiltration in gastric adenocarcinomas and associated immune stroma. | OBJECTIVE: Recent data supports a significant role for immune checkpoint inhibitors in the treatment of solid tumours. Here, we evaluate gastric and gastro-oesophageal junction (G/GEJ) adenocarcinomas for their expression of programmed death-ligand 1 (PD-L1), infiltration by CD8+ T cells and the relationship of both fa... | [
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"Aged, 80 and over",
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20061179 | A combined molecular dynamic simulation and urea 14N NMR relaxation study of the urea-lysozyme system. | Urea in the lysozyme solvation shell has been studied by utilizing a combination of urea 14N, water 17O NMR relaxation experiments and a molecular dynamics simulation of the urea-lysozyme system. Samples with lysozyme in the native fold in water as well as in 3M urea have been studied, as well as denatured lysozyme in ... | [
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11679087 | Ubiquitin immunoreactivity in presumed spinal interneurones in motor neurone disease. | Previous studies have demonstrated the presence of ubiquitin-immunoreactivity (Ub-IR) as inclusions and skeins in motor neurones of both the familial and sporadic forms of motor neurone disease (MND). There is evidence that interneurones also degenerate in MND, but Ub-IR in ventral horn spinal interneurones has not bee... | [
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12762003 | [Determining the site of airway obstruction in obstructive sleep apnea with airway pressure measurements during sleep]. | OBJECTIVE: Determine the site(s) of upper airway obstruction and the influence of sleep stage on the pattern of obstruction with upper airway (UA) pressure measurement. Analyses the clinical value of UA pressure measurement and it's influenced factors.METHODS: 30 OSAS patients underwent UA pressure measurement during p... | [
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8382432 | Ovulation induction with low-dose follicle-stimulating hormone in women with the polycystic ovary syndrome. | Fifty infertile women with the polycystic ovary syndrome (PCOS) were treated for 66 cycles with low-dose FSH stimulation starting with 75 IU FSH for two weeks before eventual stepwise increases in the gonadotropin dose occurred. An unifollicular response was observed in 35 (53%) cycles and in 20 (30%) cycles there were... | [
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2449,
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2951,
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"Female",
"Follicle Stimulating Hormone",
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"Infertility, Female",
"Ovulation Induction",
"Polycystic Ovary Syndrome",
"Pregnancy",
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26719083 | Cholesterol granuloma of a Haller cell associated with unilateral exophthalmos and diplopia. | Cholesterol granuloma is rare in the paranasal sinuses. We present what is to our knowledge the first case of cholesterol granuloma of a Haller cell associated with unilateral exophthalmos and diplopia in a 55-year-old man. | [
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16194,
12829,
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35,
4969,
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"Middle Aged"
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17686906 | Beneficial effect of spironolactone administration on ethynylestradiol-induced cholestasis in the rat: involvement of up-regulation of multidrug resistance-associated protein 2. | The effect of spironolactone (SL) administration on 17alpha-ethynylestradiol (EE)-induced cholestasis was studied, with emphasis on expression and activity of Mrps. Adult male Wistar rats were divided into the following groups: EE (5 mg/kg daily for 5 days, s.c.), SL (200 micromol/kg daily for 3 days, i.p.), EE+SL (sam... | [
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15380453 | Association between leisure time physical activity and markers of chronic inflammation related to coronary heart disease. | BACKGROUND: Some markers of chronic inflammation have been recognized as predictors of cardiovascular risk in apparently healthy subjects and in patients with coronary heart disease (CHD). High sensitivity C-reactive protein (CRP) appears to be the most useful marker in clinical settings. Several studies reported assoc... | [
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9486801 | Increased apoptosis of motoneurons and altered somatotopic maps in the brachial spinal cord of Hoxc-8-deficient mice. | Mice deficient for the homeotic gene Hoxc-8 suffer from a congenital prehension deficiency of the forepaw. During embryogenesis, Hoxc-8 is highly expressed in motoneurons within spinal cord segments C7 to T1. These motoneurons innervate forelimb distal muscles that move the forepaw. In Hoxc-8 mutant embryos, formation ... | [
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20449821 | [Body-packer & body-stuffer - a medical challenge]. | Since the seventies, the practice of drug smuggling in the form of body packing has increased in the Western world. The goal of our study was to present an algorithm for the safe management of intracorporal drug transport based on clinical experience and current evidence. The retrospective study, conducted over the pas... | [
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30196667 | Infection Status with Metagonimus spp. Metacercariae in Fishes from Seomjin-gang and Tamjin-gang in Republic of Korea. | To grasp the infection status of Metagonimus spp. metacercariae (MsMc), the freshwater fishes were surveyed from Seomjin-gang (river) and Tamjin-gang in the Republic of Korea. Total 1,604 fishes from 7 local sites of Seomjin-gang and 1,649 fishes from 2 sites of Tamjin-gang were examined for 6 years (2012-2017) by the ... | [
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20165,
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"Fishes",
"Fresh Water",
"Heterophyidae",
"Metacercariae",
"Prevalence",
"Republic of Korea",
"Trematode Infections"
] | {
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31540534 | Regenerative Potential of the Product "CardioCell" Derived from the Wharton's Jelly Mesenchymal Stem Cells for Treating Hindlimb Ischemia. | In recent years, mesenchymal stem cells (MSCs) have emerged as a promising therapeutic modality in regenerative medicine. They hold great promise for treating civilization-wide diseases, including cardiovascular diseases, such as acute myocardial infarction and critical limb ischemia. MSCs isolated from Wharton's jelly... | [
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} |
16554917 | Spontaneously ruptured uterine angioleiomyoma. | Angioleiomyoma is an uncommon type of leiomyoma of the uterus that originates from smooth muscle cells and contains thick-walled vessels. A 45-year-old woman with the complaint of lower abdominal pain was admitted to the hospital. In the operation a ruptured, bleeding uterine tumor was seen. She underwent total hystere... | [
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"Immunohistochemistry",
"Lipoma",
"Middle Aged",
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] | {
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27796352 | Filarial infection influences mosquito behaviour and fecundity. | Understanding vector-parasite interactions is increasingly important as we move towards the endpoint goals set by the Global Programme for the Elimination of Lymphatic Filariasis (GPELF), as interaction dynamics may change with reduced transmission pressure. Elimination models used to predict programmatic endpoints inc... | [
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} |
10743716 | A modified staining method for connective tissue in semi-thin histological sections of peripheral and cranial nerves. | A simple staining method for collagen in semi-thin sections of nerves is described. This technique consists of applying basic fuchsin (0.05%) solution for 2 min. to +/- 1.25 microns plastic resin-embedded sections after routine toluidine blue staining. This staining method clearly demonstrates the amount and orientatio... | [
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2902098 | No evidence for the differential antagonism of the initial fast and secondary slow contractile responses of the rat portal vein to phenylephrine, 5-hydroxytryptamine or methacholine. | 1. The present study was to ascertain whether drugs cause differential antagonism of the initial fast and secondary slow contractile responses to phenylephrine, 5-HT and methacholine of the rat portal vein. 2. Cocaine (5 x 10(-6) M) had no effect on the responses to methacholine. Cocaine potentiated the initial fast bu... | [
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30415339 | Agrobacterium-Mediated Transformation of Solanum tuberosum L., Potato. | Potato is considered the fourth most important food crop in the world, and the most important non-cereal crop. Potato is transformed using Agrobacterium tumefaciens with relative ease. Several improvements have been made in the last 20 years with respect to tissue culture, transformation, and regeneration of potato. Th... | [
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2420,
1327,
1173,
636,
5838
] | [
"Agrobacterium tumefaciens",
"Genetic Vectors",
"Plants, Genetically Modified",
"Plasmids",
"Solanum tuberosum",
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] | {
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} |
12794697 | Expression studies of two novel in CIS-mutations identified in an intermediate case of Hunter syndrome. | Hunter syndrome (Mucopolysaccharidosis type II) is a rare X-linked recessive lysosomal storage disorder caused by the deficiency of the enzyme iduronate-2-sulfatase (IDS). To date, more than 200 different mutations have been reported in the IDS gene, located on Xq27.3-q28. Here, we report two new mutations (M488I and G... | [
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"Animals",
"Base Sequence",
"COS Cells",
"DNA Mutational Analysis",
"DNA, Complementary",
"Genetic Counseling",
"Genetic Linkage",
"Genotype",
"Humans",
"Iduronate Sulfatase",
"In Vitro Techniques",
"Molecular Sequence Data",
"Mucopolysaccharidosis II",
"Mutagenesis, Site-Directed",
"Mut... | {
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15566390 | Effects of glutamate transport substrates and glutamate receptor ligands on the activity of Na-/K(+)-ATPase in brain tissue in vitro. | 1. It has been suggested that Na+/K(+)-ATPase and Na(+)-dependent glutamate transport (GluT) are tightly linked in brain tissue. In the present study, we have investigated Na+/K(+)-ATPase activity using Rb+ uptake by 'minislices' (prisms) of the cerebral cortex. This preparation preserves the morphology of neurons, syn... | [
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"Brain",
"Enzyme Inhibitors",
"Excitatory Amino Acid Antagonists",
"Female",
"Glutamic Acid",
"In Vitro Techniques",
"Ionophores",
"Ligands",
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"Microscopy, Electron",
"Neurotoxins",
"Ouabain",
"Rats",
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21880798 | Neuropilin-2 expression in papillary thyroid carcinoma: correlation with VEGF-D expression, lymph node metastasis, and VEGF-D-induced aggressive cancer cell phenotype. | CONTEXT: Neuropilin-2 (Nrp2) is a coreceptor for vascular endothelial growth factor-D (VEGF-D) that is expressed on the surface of endothelial cells. Recently, Nrp2 was shown to play a role in lymph node metastasis and promotion of cancer cell migration. VEGF-D also promotes lymphangiogenesis, which in turn promotes tu... | [
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"Cell Line, Tumor",
"Cell Movement",
"Female",
"Humans",
"Lymph Nodes",
"Lymphatic Metastasis",
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"Middle Aged",
"Neuropilin-2",
"Phenotype",
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"Vascular Endothelial Growth Factor D"
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19172406 | Chromatin condensation in terminally differentiating mouse erythroblasts does not involve special architectural proteins but depends on histone deacetylation. | Terminal erythroid differentiation in vertebrates is characterized by progressive heterochromatin formation and chromatin condensation and, in mammals, culminates in nuclear extrusion. To date, although mechanisms regulating avian erythroid chromatin condensation have been identified, little is known regarding this pro... | [
30,
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4110,
7866,
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"Chickens",
"Chromatin",
"Erythroblasts",
"Friend murine leukemia virus",
"Histone Deacetylase Inhibitors",
"Histone Deacetylases",
"Histones",
"Hydroxamic Acids",
"Mice",
"Nucleosomes"
] | {
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31519594 | Solitary Cerebral Metastases vs | BACKGROUND/AIM: The differentiation between cerebral metastases (CM) and high-grade gliomas (HGG) can be difficult on magnetic resonance imaging (MRI). The aim of this study was to evaluate the usefulness of searching two MRI signs (signal alteration in the adjacent cortex, SAAC, and peripheral rim sign, PRS), in order... | [
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"Adult",
"Aged",
"Aged, 80 and over",
"Brain Neoplasms",
"Cerebral Cortex",
"Diagnosis, Differential",
"Female",
"Glioma",
"Humans",
"Magnetic Resonance Imaging",
"Male",
"Middle Aged",
"Neoplasm Grading",
"ROC Curve",
"Radiographic Image Enhancement",
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] | {
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21743993 | Expression, characterization and 2,4,6-trichlorophenol degradation of laccase from Monilinia fructigena. | A novel laccase gene from Monilinia fructigena was synthesized chemically according to the yeast bias codon and integrated into the genome of Pichia pastoris GS115 by electroporation. The expressed enzyme was recovered from the culture supernatant and purified. The result of enzyme activity assay and SDS-PAGE demonstra... | [
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"Ascomycota",
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"Copper",
"Electrophoresis, Polyacrylamide Gel",
"Enzyme Stability",
"Genetic Vectors",
"Guaiacol",
"Indicators and Reagents",
"Ions",
"Isoelectric Point",
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... | {
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16920823 | Human T-cell leukemia virus type 1 tax dysregulates beta-catenin signaling. | Dysregulation of beta-catenin signaling has been implicated in the malignant transformation of cells. However, the role of beta-catenin in the human T-cell leukemia virus type 1 (HTLV-1)-induced transformation of T cells is unknown. Here we found that beta-catenin protein was overexpressed in the nucleus and that beta-... | [
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1432706 | Mitochondrial function in type I cells isolated from rabbit arterial chemoreceptors. | 1. In this, and the accompanying paper (Duchen & Biscoe, 1992), we test the hypothesis that the oxygen sensitivity of mitochondrial electron transport forms a basis for transduction in the carotid body, the primary peripheral arterial oxygen sensor. We here describe for isolated type I cells the changes in autofluoresc... | [
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990,
384,
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"Chemoreceptor Cells",
"Cyanides",
"Flavin-Adenine Dinucleotide",
"Fluorescence",
"Mitochondria",
"NADP",
"Oxygen Consumption",
"Rabbits"
] | {
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23002164 | Variable length chloroplast markers for population genetic studies in Acmispon (Fabaceae). | PREMISE OF THE STUDY: To estimate genetic structure, chloroplast loci containing length-variable regions were developed for two legumes, Acmispon argophyllus and A. dendroideus. •METHODS AND RESULTS: Primers for 14 chloroplast loci containing repeat regions were developed from the chloroplast genome sequence of the leg... | [
631,
7952,
7658,
4081,
8097,
2395,
896,
1444
] | [
"Alleles",
"Chloroplasts",
"Colorado",
"Fabaceae",
"Genetic Loci",
"Genetic Markers",
"Genetics, Population",
"Polymorphism, Genetic"
] | {
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21390565 | Determination of cyanide in blood by electrospray ionization tandem mass spectrometry after direct injection of dicyanogold. | An electrospray ionization tandem mass spectrometric (ESI-MS-MS) method has been developed for the determination of cyanide (CN(-)) in blood. Five microliters of blood was hemolyzed with 50 ìL of water, then 5 ìL of 1 M tetramethylammonium hydroxide solution was added to raise the pH of the hemolysate and to liberate C... | [
15480,
761,
5263,
17236,
3,
6655,
97,
1253,
1306,
355
] | [
"Carbon Monoxide Poisoning",
"Case-Control Studies",
"Cyanides",
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"Humans",
"Limit of Detection",
"Reproducibility of Results",
"Smoking",
"Spectrometry, Mass, Electrospray Ionization",
"Tandem Mass Spectrometry"
] | {
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17002790 | Comparative sequence analysis reveals an intricate network among REST, CREB and miRNA in mediating neuronal gene expression. | BACKGROUND: Two distinct classes of regulators have been implicated in regulating neuronal gene expression and mediating neuronal identity: transcription factors such as REST/NRSF (RE1 silencing transcription factor) and CREB (cAMP response element-binding protein), and microRNAs (miRNAs). How these two classes of regu... | [
6399,
614,
6793,
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548,
1030,
7628,
2118,
8161,
2677
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"Gene Expression Regulation",
"Genome, Human",
"Humans",
"MicroRNAs",
"Nerve Tissue Proteins",
"Nervous System Physiological Phenomena",
"Repressor Proteins",
"Sequence Analysis",
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18590189 | [Optimization of matrix formulation of effective parts cataplasm of Pogostemon cablin by uniform design]. | OBJECTIVE: To optimize the matrix formulation of the effective part Cataplasm of Pogostemon Cablin.METHOD: The optimal preparation prescription was selected by U17 (17(11)) uniform design,and the tacking strength, cohesive strength and transdermal speed constant were used as test indexes. The equations of three test in... | [
9850,
48,
3651,
604,
12810,
642,
4136,
6967
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"Adhesiveness",
"Biocompatible Materials",
"Chemistry, Pharmaceutical",
"Drugs, Chinese Herbal",
"Lamiaceae",
"Regression Analysis",
"Skin Absorption",
"Volatilization"
] | {
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26929068 | Synthesis of Aryldifluoroamides by Copper-Catalyzed Cross-Coupling. | A copper-catalyzed coupling of aryl, heteroaryl, and vinyl iodides with á-silyldifluoroamides is reported. The reaction forms á,á-difluoro-á-aryl amides from electron-rich, electron-poor, and sterically hindered aryl iodides in high yield and tolerates a variety of functional groups. The aryldifluoroamide products can ... | [
3674,
988,
659,
10127
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"Amides",
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"Copper",
"Fluorine"
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6816143 | [Bacteriocinogenic typing of lactobacilli]. | Sensitivity of 588 strains of Lactobacilli belonging to 15 species was studied with respect to 39 bacteriocinogenic strains of Lactobacilli producing 39 variants of bacteriocins. The study provided a set of 20 indicator strains of Lactobacilli. With the use of this set it is possible to mark Lactobacilli of various spe... | [
7415,
4206,
3036,
12750,
18832
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"Bacteriocins",
"Bacteriological Techniques",
"Lactobacillus",
"Lactobacillus acidophilus",
"Lactobacillus casei"
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29702124 | Identification of large cryptic plasmids in Clostridioides (Clostridium) difficile. | Clostridioides (Clostridium) difficile is a major bacterial pathogen of both humans and animals. Several species of pathogenic clostridia are known to harbour large plasmids with combinations of virulence, antibiotic resistance and metabolism determinants. Small cryptic plasmids have been previously identified in C. di... | [
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5586,
12422,
5291,
219,
2254,
1035,
1173,
1368,
1336,
2050,
1361
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"Bacterial Typing Techniques",
"Bacteriophages",
"Clostridioides difficile",
"DNA Replication",
"Genetic Variation",
"Open Reading Frames",
"Phylogeny",
"Plasmids",
"Recombination, Genetic",
"Sequence Analysis, DNA",
"Virulence",
"Virulence Factors"
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16445284 | Global effects of the energetics of coenzyme binding: NADPH controls the protein interaction properties of human cytochrome P450 reductase. | The thermodynamics of coenzyme binding to human cytochrome P450 reductase (CPR) and its isolated FAD-binding domain have been studied by isothermal titration calorimetry. Binding of 2',5'-ADP, NADP(+), and H(4)NADP, an isosteric NADPH analogue, is described in terms of the dissociation binding constant (K(d)), the enth... | [
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31716748 | On the identity of Tettigonia krugeri Massa from Libya with some remarks on variability of Tettigonia species (Orthoptera: Tettigoniidae; Tettigoniinae). | Morphological and genetic data allowed the authors to resurrect the name Tettigonia krugeri Massa, 1998 as a valid species. It is currently known only from two specimens (one male and one female) collected in Cirenaica (Libya). | [
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2766297 | Cytotoxic and genotoxic effects of areca nut-related compounds in cultured human buccal epithelial cells. | Because betel quid chewing has been linked to the development of oral cancer, pathobiological effects of an aqueous areca nut extract, four areca nut alkaloids (arecoline, guvacoline, guvacine, and arecaidine), and four nitrosated derivatives [N-nitrosoguvacoline, N-nitrosoguvacine, 3-(N-nitrosomethylamino)propionaldeh... | [
15829,
4741,
195,
2846,
3,
2249,
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"Colony-Forming Units Assay",
"DNA Damage",
"Epithelium",
"Humans",
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"Nitroso Compounds"
] | {
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26427384 | Multi-output Model with Box-Jenkins Operators of Quadratic Indices for Prediction of Malaria and Cancer Inhibitors Targeting Ubiquitin- Proteasome Pathway (UPP) Proteins. | The ubiquitin-proteasome pathway (UPP) is the primary degradation system of short-lived regulatory proteins. Cellular processes such as the cell cycle, signal transduction, gene expression, DNA repair and apoptosis are regulated by this UPP and dysfunctions in this system have important implications in the development ... | [
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"Databases, Pharmaceutical",
"Drug Discovery",
"Humans",
"Malaria",
"Molecular Targeted Therapy",
"Neoplasms",
"Proteasome Endopeptidase Complex",
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7328548 | The British Telecom radiopaging service in general practice. | This paper reports a new radiopaging service supplied by British Telecom that will eventually cover the whole United Kingdom. The use of this service by a three-man practice is described. The service is considered to be a major development in communications that will be of interest to most general practitioners. | [
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477,
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"England",
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8586343 | Age estimation from the permanent molar in northeast China by the method of average stage of attrition. | A new method of age estimation using permanent molars, the method of average stage of attrition (ASA), is described. A total of 633 molars, including the first molar (M1) and the second molar (M2) on both jaws, was collected from 57 cadavers and 54 modern dry skulls in northeast China. The attrition condition of the mo... | [
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160,
5103,
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"Age Determination by Teeth",
"Aged",
"Aging",
"China",
"Dentin",
"Female",
"Humans",
"Male",
"Middle Aged",
"Molar",
"Regression Analysis",
"Sensitivity and Specificity"
] | {
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} |
25690295 | Investigation of chemomarkers of astragali radix of different ages and geographical origin by NMR profiling. | Astragalus roots from Astragalus membranaceus Bunge or Astragalus membranaceus var. mongholicus (Bunge) Hsiao are among the most popular traditional medicinal plants due to their diverse therapeutic uses based on their tonic, antinephritic, immunostimulant, hepatoprotectant, diuretic, antidiabetic, analgesic, expectora... | [
20088,
10203,
713,
7573,
7663,
1074,
8879
] | [
"Astragalus propinquus",
"Isoflavones",
"Magnetic Resonance Spectroscopy",
"Metabolome",
"Metabolomics",
"Plant Roots",
"Saponins"
] | {
"A": 1,
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} |
8626597 | In vivo assembly of the tau-complex of the DNA polymerase III holoenzyme expressed from a five-gene artificial operon. Cleavage of the tau-complex to form a mixed gamma-tau-complex by the OmpT protease. | A plasmid was constructed that encodes all five subunits of the Escherichia coli tau-complex on a single artificially constructed operon under the control of an inducible promoter. The proteins tau, delta, delta , chi, and psi overproduced from this artificial operon assemble efficiently in vivo, providing an efficient... | [
439,
1225,
9821,
352,
1531,
37,
6059,
7389,
1173,
354,
4603
] | [
"Base Sequence",
"Cloning, Molecular",
"DNA Polymerase II",
"Escherichia coli",
"Macromolecular Substances",
"Molecular Sequence Data",
"Oligodeoxyribonucleotides",
"Operon",
"Plasmids",
"Protein Processing, Post-Translational",
"Serine Endopeptidases"
] | {
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} |
24464256 | Cerebral hyperperfusion syndrome after endovascular reconstruction of carotid artery in high-flow carotid-jugular fistula. | We describe the occurrence of cerebral hyperperfusion syndrome (CHS) in a case of long-standing carotid-jugular fistula (CJF) treated by endovascular reconstruction of the carotid artery. A 43-year-old male with a high-flow CJF between the internal carotid artery (ICA) and internal jugular vein underwent endovascular r... | [
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695,
233,
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"Adult",
"Angiography, Digital Subtraction",
"Antihypertensive Agents",
"Arteriovenous Fistula",
"Carotid Artery, Internal",
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"Hypertension",
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19362099 | An approximate likelihood for genetic data under a model with recombination and population splitting. | We describe a new approximate likelihood for population genetic data under a model in which a single ancestral population has split into two daughter populations. The approximate likelihood is based on the 'Product of Approximate Conditionals' likelihood and 'copying model' of Li and Stephens [Li, N., Stephens, M., 200... | [
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9176558 | Reduction of the ex vivo production of tumor necrosis factor alpha by alveolar phagocytes after administration of coal fly ash and copper smelter dust. | We investigated the effect of intratracheally instilled coal fly ash (FA) and copper smelter dust (CU) on the lung integrity and on the ex vivo release of tumor necrosis factor alpha (TNF-alpha) by alveolar phagocytes. Groups of female NMRI mice received a single intratracheal administration of different particles norm... | [
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31003198 | Does austerity really kill? | A growing body of the literature has argued that austerity has been bad for health, though without directly measuring austerity. This paper explicitly distinguishes the association of mortality with macroeconomic fluctuations from that with fiscal policy measures, using data for 28 European Union (EU) countries coverin... | [
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18343177 | n of 1 trial for an ornithine transcarbamylase deficiency carrier. | Ornithine transcarbamylase deficiency (OTCD) is an X-linked disorder of the urea cycle. It is often fatal in affected males. Treatment for affected individuals includes dietary protein restriction, activation of alternative pathways of nitrogen excretion and L-arginine supplementation. Depending on the amount of X chro... | [
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23524136 | The crystal structure of the lumenal domain of Erv41p, a protein involved in transport between the endoplasmic reticulum and Golgi apparatus. | Erv41p is a conserved integral membrane protein that is known to play a role in transport between the endoplasmic reticulum and Golgi apparatus, part of the early secretory pathway of eukaryotes. However, the exact function of the protein is not known, and it shares very low sequence identity with proteins of known str... | [
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9280998 | [Late ischemia and carpal tunnel syndrome secondary to catheterization of the radial artery]. | Invasive measurement of blood pressure has many advantages. Although arterial canalization is a low-risk technique of great benefit to the patient, complications must be looked for. We report the case of a man who underwent triple coronary bypass with arterial canalization requiring several punctures to achieve. Two we... | [
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9711,
1078,
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2977,
35,
2647,
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17397008 | Individuals with pulmonary tuberculosis have lower levels of circulating CD1d-restricted NKT cells. | Mycobacterium tuberculosis (MTB) is a leading cause of mortality worldwide from an infectious agent. Natural killer T (NKT) cells recognize mycobacterial antigens and contribute to anti-MTB immunity in mouse models. NKT cells were measured in subjects with pulmonary tuberculosis, MTB-exposed individuals, and healthy co... | [
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"Killer Cells, Natural",
"Leukocytes, Mononuclear",
"Male",
"Mycobacterium tuberculosis",
"Tuberculosis, Pulmonary"
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