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1454421 | On the use of age-intensity data to detect immunity to parasitic infections, with special reference to Schistosoma mansoni in Kenya. | We consider two phenomena, related to the host age-intensity profiles of parasitic infections, which have been suggested to be indicative of acquired immunity: (i) a lower age of peak intensity among more intensely infected hosts; and (ii) a decline with age in the dispersion of the distribution of parasites between ho... | [
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"Kenya",
"Models, Biological",
"Parasite Egg Count",
"Parasitic Diseases",
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"Schistosoma mansoni",
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23429595 | Pravastatin improves endothelial function in arteries used in coronary bypass grafting. | Internal mammary artery (IMA) and radial artery (RA) are the 2 main arterial conduits used in coronary artery bypass grafting (CABG). The aim of this study was to analyze in vitro the vasoreactive properties in both vessels and to investigate the effects of pravastatin incubation on vascular function. IMA and RA rings ... | [
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"Acetylcholine",
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"Coronary Artery Disease",
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16697321 | Effects of time, dose, and inversion time for acute myocardial infarct size measurements based on magnetic resonance imaging-delayed contrast enhancement. | OBJECTIVES: This study sought to investigate the influence of time, dose, and inversion time (TI) and their interactions on myocardial infarct size measurements to establish the foundation for a standardized protocol for multicenter trials.BACKGROUND: There is growing interest in using magnetic resonance imaging (MRI) ... | [
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8107932 | Prolonged surveillance of dexfenfluramine in severe obesity. | Forty-two obese patients entered a placebo-controlled, double-blind 1-year study on dexfenfluramine, a serotonergic anorectic drug. Obesity was severe (mean body mass index 38.4 kg/m2), and of early onset and long duration. A mean of 8 attempts to lose weight was undertaken. After randomisation to 1 year of dexfenflura... | [
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19188787 | Diffusion-weighted magnetic resonance imaging of breast lesions: first experiences at 3 T. | PURPOSE: Dynamic contrast-enhanced magnetic resonance imaging (MRI) has been established as a valuable tool for the detection of breast cancer. There is evidence suggesting that diffusion-weighted imaging (DWI) may be useful to distinguish between malignant and benign breast lesions. We seek to evaluate the ability of ... | [
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"Contrast Media",
"Diffusion Magnetic Resonance Imaging",
"Female",
"Gadolinium DTPA",
"Humans",
"Middle Aged",
"Observer Variation",
"Pilot Projects",
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30321057 | HIV-Nef Protein Persists in the Lungs of Aviremic Patients with HIV and Induces Endothelial Cell Death. | It remains a mystery why HIV-associated end-organ pathologies persist in the era of combined antiretroviral therapy (ART). One possible mechanism is the continued production of HIV-encoded proteins in latently HIV-infected T cells and macrophages. The proapoptotic protein HIV-Nef persists in the blood of ART-treated pa... | [
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8625443 | Enhancement of BALB/c 3T3 cells transformation by 1,2-dibromoethane promoting effect. | Two of the most representative halogenated aliphatic hydrocarbons, 1,2-dibromoethane and 1,1,2,2-tetrachloroethane, were tested in the two-stage cell transformation model for analysing the promoting ability. Both of these compounds had previously been found to exert genotoxic effects, probably acting as moderate initia... | [
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"Carcinogens",
"Cell Transformation, Neoplastic",
"Dose-Response Relationship, Drug",
"Ethane",
"Ethylene Dibromide",
"Hydrocarbons, Chlorinated",
"Methylnitronitrosoguanidine",
"Mice",
"Tetradecanoylphorbol Acetate"
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30764690 | Racial/Ethnic Differences in 25-Hydroxy Vitamin D and Parathyroid Hormone Levels and Cardiovascular Disease Risk Among Postmenopausal Women. | Background Recent evidence suggests that racial/ethnic differences in circulating levels of free or bioavailable 25-hydroxy vitamin D (25[ OH ]D) rather than total 25( OH )D may explain apparent racial disparities in cardiovascular disease ( CVD ). We prospectively examined black-white differences in the associations o... | [
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30108205 | Riluzole reduces amyloid beta pathology, improves memory, and restores gene expression changes in a transgenic mouse model of early-onset Alzheimer's disease. | Alzheimer's disease (AD) represents a major healthcare burden with no effective treatment. The glutamate modulator, riluzole, was shown to reverse many AD-related gene expression changes and improve cognition in aged rats. However, riluzole's effect on amyloid beta (Aâ) pathology, a major histopathological hallmark of ... | [
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31473048 | Value of cross-sectional area of median nerve by MRI in carpal tunnel syndrome. | BACKGROUND: Carpal tunnel syndrome is diagnosed based on history, physical examination, and nerve conduction testing; however, there are no clear criteria for the diagnosis of carpal tunnel syndrome. Recently, studies have aimed to diagnose carpal tunnel syndrome through ultrasound or MRI. The purpose of this study was... | [
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16861016 | Inappropriate secretion of antidiuretic hormone: a rare complication after carotid endarterectomy. | The syndrome of inadequate secretion of the antidiuretic hormone (SIADH) is a very rare complication after carotid endarterectomy, characterized by hyponatremia, decrease of serum osmolarity as well as an increase in urinary osmolarity. We report the case of an 80-year-old woman who developed, 24 hours after the surger... | [
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11918328 | Safety guidelines for radiolocalised sentinel node resection. | BACKGROUND: Sentinel node radiolocalisation procedures are associated with low levels of radiation exposure. Radioactive material is present in the operating theatre and pathology laboratory. In most hospitals there are no official regulations in place for sentinel node radiation exposure.AIM: To establish guidelines o... | [
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"Breast Neoplasms",
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11383761 | Geometric ray tracing analysis of visual acuity after laser in situ keratomileusis. | PURPOSE: Using a geometric ray tracing model, we explain the increase in visual acuity observed in myopic patients after laser in situ keratomileusis (LASIK).METHODS: This study included 37 eyes of 23 patients who underwent LASIK. All patients had myopia and a spectacle-corrected visual acuity of 0.95 or worse. Clinica... | [
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29126142 | Stereotactic Radiosurgery in the Management of Limited (1-4) Brain Metasteses: Systematic Review and International Stereotactic Radiosurgery Society Practice Guideline. | BACKGROUND: Guidelines regarding stereotactic radiosurgery (SRS) for brain metastases are missing recently published evidence.OBJECTIVE: To conduct a systematic review and provide an objective summary of publications regarding SRS in managing patients with 1 to 4 brain metastases.METHODS: Using Preferred Reporting Item... | [
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27799062 | Middle ear microbiome differences in indigenous Filipinos with chronic otitis media due to a duplication in the A2ML1 gene. | BACKGROUND: Previously rare A2ML1 variants were identified to confer otitis media susceptibility in an indigenous Filipino community and in otitis-prone US children. The goal of this study is to describe differences in the middle ear microbiome between carriers and non-carriers of an A2ML1 duplication variant that incr... | [
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8027442 | Highly selective effects of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 on intact and injured basal forebrain magnocellular neurons. | Cholinergic neurons of the basal nucleus complex (BNC) respond to nerve growth factor (NGF), the first member of a polypeptide gene family that also includes brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4/5 (NT-4/5). NGF, BDNF, and NT-3 are enriched in hippocampus. In addition, NGF ... | [
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9085408 | Does noise stress modulate effects of smoking/nicotine? Mood, vigilance, and EEG responses. | Effects of smoking multiple cigarettes on EEG, vigilance, and subjective state were assessed in a repeated measures design where noise level (high versus minimal) was crossed with nicotine dose (quasi-ad lib own versus 1.0 mg FTC nicotine machine-delivered dose versus 0.05 mg FTC nicotine machine-delivered dose). Vigil... | [
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299819 | The radiological diagnosis of meningiomas, the impact of EMI scanning. | A review of the impact of computerized axial tomography on the radiological diagnosis of meningiomas is presented. Seventy-one intracranial and eight orbital cases have been examined by this new method using the 160 X 160 matrix. The diagnostic accuracy of the method is compared with established neuroradiological metho... | [
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1895166 | Thermal enhancement of ACNU and potentiation of thermochemotherapy with ACNU by hypertonic glucose in the BT4An rat glioma. | Hyperthermia increases the cytotoxicity of the nitrosourea BCNU (carmustine). Glucose given before treatment may further increase the value of thermochemotherapy, presumably by lowering tumour pH through blood flow reduction. The water-soluble ACNU (nimustine) is an alternative to other nitrosoureas in the treatment of... | [
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17123859 | Design of a knee rotatory kinaesthetic device. | The anterior cruciate ligament (ACL) constrains rotatory motion at the knee and is commonly injured during rotational movements in athletic activity. This densely innervated ligament is assumed to play a role in knee proprioception, however, no study has measured proprioception in a manner relevant to either the kinema... | [
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2575531 | Beta-adrenoceptor-mediated cAMP accumulation in cardiac cells: effects of nebivolol. | The effects of nebivolol, the racemic mixture of the SRRR and RSSS enantiomers, on beta-adrenoceptor-mediated cAMP accumulation in living cardiac cells were compared to those of beta-adrenoceptor antagonists. Serum-free cultivation of cardiac cells from ventricles of 2 to 3-day-old Wistar rats resulted in a population ... | [
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21970492 | Pleomorphic (spindle and squamous cell) carcinoma arising in a peripheral mixed squamous and glandular papilloma in a 70-year-old man. | Solitary papillomas of the bronchial tree are rare, particularly in the distal airways. When encountered, solitary papillomas are not frequently found to undergo malignant transformation. When this does happen, it is usually a squamous cell carcinoma arising in a human papillomavirus-associated squamous papilloma (usua... | [
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26801359 | Direct Dynamic Kinetic Analysis and Computer Simulation of Growth of Clostridium perfringens in Cooked Turkey during Cooling. | This research applied a new 1-step methodology to directly construct a tertiary model that describes the growth of Clostridium perfringens in cooked turkey meat under dynamically cooling conditions. The kinetic parameters of the growth models were determined by numerical analysis and optimization using multiple dynamic... | [
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15612512 | [Validation of sentinel node in breast cancer]. | BACKGROUND: The sentinel lymph node biopsy in breast cancer can be used instead of axillary dissection when the node is negative because the sentinel lymph node (SLN) represents the first node that receive lymphatic drainage and may predict the tumor status of the entire lymph node group, so it may avoid a more morbid ... | [
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9486887 | Endorectal advancement flap in perianal Crohn's disease. | The aim of this study was to evaluate the outcome of patients undergoing endorectal advancement flap repair for perianal Crohn's disease relative to the primary site of intestinal Crohn's disease. From January 1991 to December 1995, 31 consecutive endorectal advancement flap repairs were performed in 26 patients. The r... | [
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30220554 | Inhibition of Atypical Protein Kinase C Reduces Inflammation-Induced Retinal Vascular Permeability. | Changes in permeability of retinal blood vessels contribute to macular edema and the pathophysiology of numerous ocular diseases, including diabetic retinopathy, retinal vein occlusions, and macular degeneration. Vascular endothelial growth factor (VEGF) induces retinal permeability and macular thickening in these dise... | [
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24640915 | [Oxidation behavior and kinetics of representative VOCs emitted from petrochemical industry over CuCeOx composite oxides]. | CuCeOx composite catalysts were synthesized via coprecipitation (COP-CuCeO,) and incipient impregnation (IMP-CuCeOx) methods, respectively. The physicochemical properties of the samples were characterized by XRD, low-temperature N2 sorption, H2-TPR and O2-TPD. The influences of reactant composition and concentration, r... | [
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11454603 | Cyclooxygenase-2 does not mediate late preconditioning induced by activation of adenosine A1 or A3 receptors. | Recent studies have demonstrated that the adenosine A1 receptor agonist 2-chloro-N6-cyclopentyladenosine (CCPA) and the adenosine A3 receptor agonist N6-(3-iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA) produce a delayed phase of protection against infarction similar to the late phase of ischemic preconditioning (... | [
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7199690 | Biophysical and electrophysiological studies of hexanedione neurotoxicity. | This study examined the significance of nerve microviscosity changes which occur in 2,5-hexanedione (2,5-HD) neurotoxicity. To establish a correlation between microviscosity changes and neuronal damage, a standard axonal neuropathy (nerve section) was employed. Electrophysiological studies of the sciatic-tibial nerve o... | [
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19646540 | The polyphyletic genus Sebaea (Gentianaceae): a step forward in understanding the morphological and karyological evolution of the Exaceae. | Within the Gentianaceae-Exaceae, the most species-rich genus Sebaea has received very little attention in terms of phylogenetic or karyological investigations. As a result, the exact number of species remains vague and the relationships with the other members of the Exaceae poorly understood. In this paper, we provide ... | [
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1545335 | MCMI-II diagnosis of borderline personality disorder: base rates versus prototypic items. | The Millon Clinical Multiaxial Inventory-II (MCMI-II) profiles of 26 psychiatric inpatients diagnosed as having borderline personality disorders were compared with profiles of 42 patients with no personality disorders. The borderline group scored significantly higher on the following scales: Disclosure (X), Debasement ... | [
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10343364 | Technical solutions for quantitative and qualitative assessments of speech fluency. | Current and emerging technical solutions for the differential diagnostic evaluation and assessment of speech fluency are reviewed and discussed. These systems were selected with just one intentional bias--the need for clinicians to carry out valid, reliable, and accurate measurements of speech fluency, its disruptions,... | [
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18777947 | Pharmacokinetics of YK754, a novel If channel inhibitor in rats, dogs and humans. | The pharmacokinetics of YM758, a novel funny If current channel (If channel) inhibitor, was investigated after single intravenous (i.v.) and oral dosing to rats and dogs, and partially compared with the results in humans by using liver microsomes. After i.v. administration, the plasma YM758 concentrations decreased, wi... | [
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24299361 | Nursing a sense of family. | Rosemary Jenkinson was named nurse of the year in 1991 in recognition of her work to establish a community home for children with profound sensory disabilities. Winning the award was a confidence booster and a responsibility, she says. | [
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8211285 | A medical geographical anniversary. | It is now 200 years since L. L. Finke wrote his treatise on a global medical geography, Versuch einer allgemeinen medicinisch-praktischen Geographie. It was both the most extensive book in substantive content, and the most detailed in conceptual discussion on medical geography written to that point. Although it is one ... | [
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21884573 | â1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib. | INTRODUCTION: The overexpression of human epidermal growth factor receptor (HER)-2 in 20% of human breast cancers and its association with aggressive growth has led to widespread use of HER2-targeted therapies, such as trastuzumab (T) and lapatinib (L). Despite the success of these drugs, their efficacy is limited in p... | [
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7152883 | Dynamic osteosynthesis with angled flexible nails in recent fractures of the diaphysis of the tibia. | Dynamic osteosynthesis with curved flexible nails was introduced by Burghele for the treatment of recent fractures of the diaphysis of the tibia. Our experience in sixty patients has shown that this method of treatment produces better results than rigid AO osteosynthesis and also than osteosynthesis with rigid Kuntsche... | [
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20973842 | Community pharmacy service users' views and perceptions of alcohol screening and brief intervention. | INTRODUCTION AND AIMS: Community pharmacists have the potential to deliver alcohol screening and brief interventions (SBI) to pharmacy users. However, little is known if SBI would be utilised and views of people who might use the service. Therefore, the aim was to investigate potential barriers and enablers of pharmacy... | [
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17302168 | [Isolation and identification of a newbacterial pathogen infecting larvae of honeybee (Apismellifera ) Perish]. | A bacteroidal disease of honeybee (Apis mellifera ) larvae was found in some regions of Zhejiang Province, China , in early spring 2005. The diseased larvae lost its shine, became yellow and rotted when serious. This symptom was different to any bacteroidal disease of honeybee larval been reported. So, it is considered... | [
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11703479 | Migraine MLT-down: an unusual presentation of migraine in patients with aspartame-triggered headaches. | Aspartame, an artificial sweetener added to many foods and beverages, may trigger headaches in susceptible individuals. We report two patients with aspartame-triggered attacks in whom the use of an aspartame-containing acute medication (Maxalt-MLT) worsened an ongoing attack of migraine. | [
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6747910 | Affective disorders and ABO blood groups: new data and a reanalysis of the literature using the logistic transformation of proportions. | No statistically significant associations were found between ABO blood group distributions and RDC subtype diagnoses in 79 subjects with unipolar (single episode and recurrent) and bipolar major depressive disorder using data from our sample. We discuss methodological issues related to the control samples and choice of... | [
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15659604 | Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42. | In studies of Alzheimer's disease pathogenesis there is an increasing focus on mechanisms of intracellular amyloid-beta (Abeta) generation and toxicity. Here we investigated the inhibitory potential of the 42 amino acid Abeta peptide (Abeta1-42) on activity of electron transport chain enzyme complexes in human mitochon... | [
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14577622 | Pyrone glycosides from Acosmium panamense (Benth.) Yacovlev. | Besides caffeic acid three pyrones have been isolated from aquous bark extracts from Acosmium panamense and their structures were determined using spectroscopical methods. Besides the already described desmethylyangonine its O4'-mono as well as the di(1-6)glucoside are found the first time. | [
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25626681 | Systematic analysis of viral genes responsible for differential virulence between American and Australian West Nile virus strains. | A variant Australian West Nile virus (WNV) strain, WNVNSW2011, emerged in 2011 causing an unprecedented outbreak of encephalitis in horses in south-eastern Australia. However, no human cases associated with this strain have yet been reported. Studies using mouse models for WNV pathogenesis showed that WNVNSW2011 was le... | [
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23267997 | [Long-term survival in 2 cases with unresectable hilar bile duct cancer and sclerosing cholangitis]. | Case 1: A 69-year-old man was admitted to a nearby clinic due to upper abdominal pain. Computed tomography revealed stenosis of the hilar bile duct and dilation of the intrahepatic bile duct in both lobes of the liver. A percutaneous transhepatic biliary drainage tube was inserted in the right anterior segment branch, ... | [
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27473305 | Prediction of influenza B vaccine effectiveness from sequence data. | Influenza is a contagious respiratory illness that causes significant human morbidity and mortality, affecting 5-15% of the population in a typical epidemic season. Human influenza epidemics are caused by types A and B, with roughly 25% of human cases due to influenza B. Influenza B is a single-stranded RNA virus with ... | [
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32050941 | Shear wave elasticity by tracing total nodule showed high reproducibility and concordance with fibrosis in thyroid cancer. | BACKGROUND: Although shear wave elastography (SWE) is reported to be useful in detecting malignant thyroid nodules, it shows a wide range of cut-off values of elasticity index (EI) in detecting malignant nodules. The cause of discrepancy remains unclear. Fibrosis of the tumors is known to increase the EI in SWE, and ma... | [
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"Elasticity",
"Elasticity Imaging Techniques",
"Female",
"Fibrosis",
"Humans",
"Male",
"Reproducibility of Results",
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4874971 | Sub-unit structure and specificity of methionyl-transfer-ribonucleic acid synthetase from Escherichia coli. | 1. The purification of methionyl-transfer-RNA synthetase from Escherichia coli by a modified technique gives a 16% yield of a protein that appears homogeneous by the criteria of disc gel electrophoresis, ultracentrifugation and end-group analysis. 2. The molecular weight is 96000 and the protein consists of two sub-uni... | [
28,
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"Amino Acid Sequence",
"Electrophoresis, Disc",
"Escherichia coli",
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"Ligases",
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"Methionine",
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"Molecular Weight",
"RNA, Messenger",
"Ultracentrifugation"
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10536765 | Attitudes of the Lebanese public regarding disclosure of serious illness. | OBJECTIVES: To measure the preference regarding disclosure of a serious diagnosis, and its determinants, of the Lebanese public.DESIGN AND SETTING: Non-random sample survey of 400 persons interviewed in health care facilities in Beirut in 1995.RESULTS: Forty-two per cent of respondents generally preferred truth not to ... | [
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961,
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12830,
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3626,
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"Attitude of Health Personnel",
"Attitude to Health",
"Educational Status",
"Female",
"Health Status",
"Humans",
"Islam",
"Lebanon",
"Male",
"Physician-Patient Relations",
"Truth Disclosure"
] | {
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18522771 | Primary and mid-term outcome of sirolimus-eluting stent implantation with angiographic guidance alone. | BACKGROUND: Usefulness and efficacy of intravascular ultrasound (IVUS) for the implantation of sirolimus-eluting stent (SES) is controversial. We investigated the primary and mid-term results of SES deployment with angiographic guidance comparing with IVUS guidance, retrospectively.METHODS AND RESULTS: SESs were deploy... | [
133,
2017,
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3470,
2,
3,
35,
3251,
1572
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"Aged",
"Coronary Angiography",
"Coronary Disease",
"Drug-Eluting Stents",
"Female",
"Humans",
"Male",
"Sirolimus",
"Ultrasonography, Interventional"
] | {
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1930042 | Pseudomyxoma peritonei--experience from a tertiary referral centre. | Pseudomyxoma peritonei is a clinical diagnosis of massive abdominal swelling by a gelatinous material, produced usually from an ovarian or appendiceal primary. It is a rare entity that is usually histologically benign but behaves clinically in a malignant fashion with recurrent growth, although not demonstrating histol... | [
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27272844 | Clinical Value of Squamous Cell Carcinoma Antigen (SCCAg) in Anal Cancer - A Single-Center Retrospective Analysis. | AIM: To assess the clinical value of squamous cell carcinoma antigen (SCCAg) in anal cancer for chemoradiotherapy (CRT) patients.PATIENTS AND METHODS: In 24 patients with SCC of the anus, SCCAg was determined before CRT and at every follow-up visit.RESULTS: 16/24 (66.7%) had normal SCCAg and 11/16 (68.8%) achieved comp... | [
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"Aged, 80 and over",
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"Anus Neoplasms",
"Chemoradiotherapy",
"Female",
"Humans",
"Male",
"Middle Aged",
"Neoplasm Recurrence, Local",
"Retrospective Studies",
"Serpins"
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24491122 | Mesalazine-probiotics beads for acetic acid experimental colitis: formulation and characterization of a promising new therapeutic strategy for ulcerative colitis. | BACKGROUND: Acetic acid ulcerative colitis (UC) is an experimental condition created due to intra-rectal administration of acetic acid which causes inflammation and ulceration in the lining of colon and rectum. In such condition, the colon cannot absorb liquid from the stools, resulting in larger volume of watery stool... | [
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1894449 | Use of Mpc-amino acids in solid phase peptide synthesis leads to improved coupling efficiencies. | The Mpc-group has a somewhat better stability than the Fmoc-group, resists catalytic hydrogenolysis, is highly stable in acidic media and its elimination product does not polymerize spontaneously. In a direct comparison of coupling efficiencies obtained in solid phase peptide syntheses using Mpc- or Fmoc-amino acids it... | [
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"Fluorenes",
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21691261 | Risk and prevention of graft failure in patients with preexisting donor-specific HLA antibodies undergoing unmanipulated haploidentical SCT. | A role of donor-specific HLA antibodies (DSA) in graft failure after SCT has been suggested, but the relevance of DSA in unmanipulated haploidentical SCT (haplo-SCT) remains unknown. We prospectively examined HLA antibodies using the Luminex-based single Ag assay for 79 adult patients undergoing unmanipulated haplo-SCT... | [
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"Female",
"Graft Rejection",
"HLA Antigens",
"Hematologic Neoplasms",
"Hematopoietic Stem Cell Transplantation",
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"Risk Factors",
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25800268 | Late sensorial alterations in different radiotherapy techniques for nasopharyngeal cancer. | Intensity-modulated radiation therapy (IMRT) for nasopharyngeal cancer (NPC) allowed a better distribution of the dose to the tumor volume, sparing surrounding structures. Aim of the study is the objective evaluation of olfactory and gustatory impairments in patients who underwent chemo-radiotherapy for NPC. Correlatio... | [
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18973640 | Junior doctor strike model of care: Reduced access block and predominant Fellow of the Australasian College for Emergency Medicine staffing improve emergency department performance. | OBJECTIVE: To describe the response and analyse ED performance during a 5-day junior doctor strike.METHODS: Data were collected via the patient information management computer system. Key performance indicators included percentage seen within maximum waiting times per triage category (TC), ED length of stay, emergency ... | [
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912,
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27796043 | Spectroscopic Properties of Amine-substituted Analogues of Firefly Luciferin and Oxyluciferin. | Spectroscopic and photophysical properties of firefly luciferin and oxyluciferin analogues with an amine substituent (NH2 , NHMe and NMe2 ) at the C6' position were studied based on absorption and fluorescence measurements. Their ð-electronic properties were investigated by DFT and TD-DFT calculations. These compounds ... | [
3665,
19940,
2075,
14703,
9714,
7981,
3226,
3818,
1873,
1306,
1150
] | [
"Amines",
"Firefly Luciferin",
"Indoles",
"Luciferases, Firefly",
"Luminescence",
"Proton Magnetic Resonance Spectroscopy",
"Pyrazines",
"Solvents",
"Spectrometry, Fluorescence",
"Spectrometry, Mass, Electrospray Ionization",
"Spectrophotometry, Ultraviolet"
] | {
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11375369 | Prevalence of polycystic ovary syndrome among premenopausal women with type 2 diabetes. | OBJECTIVE: Women with polycystic ovary syndrome (PCOS) have an increased risk for developing type 2 diabetes. Few studies have assessed women with type 2 diabetes to determine the frequency of PCOS in this population.RESEARCH DESIGN AND METHODS: To determine the prevalence of PCOS among premenopausal women with type 2 ... | [
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16893527 | Decreased plasma brain derived neurotrophic factor levels in unmedicated bipolar patients during manic episode. | BACKGROUND: Bipolar disorder (BD) has been increasingly associated with abnormalities in neuroplasticity and cellular resilience. Brain Derived Neurotrophic Factor (BDNF) gene has been considered an important candidate marker for the development of bipolar disorder and this neurotrophin seems involved in intracellular ... | [
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8400690 | Genetic variation among the Mapuche Indians from the Patagonian region of Argentina: mitochondrial DNA sequence variation and allele frequencies of several nuclear genes. | DNA samples from 60 Mapuche Indians, representing 39 maternal lineages, were genetically characterized for (1) nucleotide sequences of the mtDNA control region; (2) presence or absence of a nine base duplication in mtDNA region V; (3) HLA loci DRB1 and DQA1; (4) variation at three nuclear genes with short tandem repeat... | [
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21056687 | Neuronal nitric oxide synthase interacts with Sp1 through the PDZ domain inhibiting Sp1-mediated copper-zinc superoxide dismutase expression. | In this report we demonstrate that neuronal nitric oxide synthase (nNOS) is able to interact with Sp1 both in vivo and in vitro. In particular, we show that such interaction is mediated by the N-terminal PDZ domain of full length nNOS (fl-nNOS). In fact nNOS mutant lacking the PDZ domain (ÄnNOS) displays an impaired ab... | [
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338631 | Activity of (des-Aspartyl1)-angiotensin II and angiotensin II in man. Differences in blood pressure and adrenocortical response during normal and low sodium intake. | This study was designed to compare the effect of [des-Aspartyl(1)]-angiotensin II ([des-Asp]-A II) and angiotensin II (A II) on blood pressure and aldosterone production in man under conditions of normal and low sodium (Na) intake. Seven normal male subjects in balance on constant normal Na intake (U(Na) V 160.3+/-5.0 ... | [
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25556104 | Nanostructured lipid carriers used for oral delivery of oridonin: an effect of ligand modification on absorption. | Oridonin (Ori) is a natural compound with notable anti-inflammation and anti-cancer activities. However, therapeutic use of this compound is limited by its poor solubility and low bioavailability. Here a novel biotin-modified nanostructured lipid carrier (NLC) was developed to enhance the bioavailability of Ori. The ef... | [
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24091942 | cDNA cloning and mRNA expression of retinoid-X-receptor in the ovary of the shrimp Metapenaeus ensis. | Retinoid-X-receptor (RXR) plays an essential role in the molting process of decapod crustaceans, by forming a heterodimeric complex with the ecdysteroid receptor. However, its role during female reproduction, especially in the process of ovarian maturation, has not been characterized. To get an insight into the molecul... | [
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23246812 | Functional characterisation of p53 mutants identified in breast cancers with suboptimal responses to anthracyclines or mitomycin. | BACKGROUND: Approximately 4300 different TP53 mutations have been reported in human cancers. TP53 mutations, in particular those affecting the L2/L3 domains, are associated with resistance to anthracycline or mitomycin treatment in breast cancer patients. While many mutations have been characterised functionally, novel... | [
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31227731 | Experimental and empirical evidence shows that reducing weed control in winter cereal fields is a viable strategy for farmers. | Modern agriculture needs a paradigm shift to make the world's food production sustainable while mitigating social and environmental externalities. Although various policies to limit the use of agrochemicals have recently been implemented in the European Union, the use of both herbicides and fertilizers has remained fai... | [
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628579 | Pictorial depth and related constancy effects as a function of recognition. | It is argued that while pictorial cues must be fundamental in the perception of an extended ground plane in daily life (and, by definition, in the perception of depth in pictures), the traditional pictorial cues such as perspective or texture gradients are neither a necessary nor a sufficient basis for it. That they ar... | [
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5823,
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14639115 | Nursing externship: a collaborative endeavor between nursing education and nursing administration. | This article provides an excellent description of an 8-week summer externship program for nursing students. | [
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21467688 | Three new triterpenoid saponins from Dianthus superbus. | Three new triterpenoid saponins (1-3) were isolated from the dried aerial parts of Dianthus superbus L. (Caryophyllaceae). Their structures were established as 3-O-â-D-glucopyranosyl gypsogenic acid 28-O-[â-D-6-O-((3S)-3-hydroxyl-3-methylglutaryl)glucopyranosyl(1?6)]-â-D-glucopyranoside (1), 3-O-â-D-glucopyranosyl gyps... | [
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15028650 | Neurotensin enhances endogenous extracellular glutamate levels in primary cultures of rat cortical neurons: involvement of neurotensin receptor in NMDA induced excitotoxicity. | Primary cultures of cortical neurons were employed to investigate the modulatory effects of neurotensin on glutamate excitotoxicity and the possible neuroprotective actions of the neurotensin receptor antagonist SR48692. NT(1-13) and its biologically active fragment NT(8-13) at 10 nM (30 min) increased endogenous gluta... | [
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1878440 | Slowed transcription and rapid messenger RNA turnover contribute to a decline in synthesis of ovine trophoblast protein-1 during in vitro culture. | Ovine trophoblast protein-1 (oTP-1) is produced in massive amounts by conceptuses during the Day-12-20-period of early pregnancy. The rate of production of oTP-1 declines during culture of conceptuses, however, suggesting a role for critical intrauterine factors for continued production. The present study was conducted... | [
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22986158 | Montelukast inhibits caspase-3 activity and ameliorates oxidative damage in the spinal cord and urinary bladder of rats with spinal cord injury. | Spinal cord injury (SCI) leads to an inflammatory response that generates substantial secondary damage within the tissue besides the primary damage. Leukotrienes are biologically active 5-lipoxygenase products of arachidonic acid metabolism that are involved in the mediation of various inflammatory disorders including ... | [
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12032731 | Analysis of alterations of WFDC1, a new putative tumour suppressor gene, in hepatocellular carcinoma. | WFDC1 is a recently isolated human gene identified as a tumour suppressor gene candidate. It is not known whether alterations in this gene are associated with human cancers. The WFDC1 gene maps in human chromosome 16q24, an area of frequent loss of heterozygosity (LOH) in several tumour types, in particular in hepatoce... | [
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11911576 | Multiple-center study of reduced-concentration triamcinolone topical solution for the treatment of dogs with known or suspected allergic pruritus. | OBJECTIVE: To determine the efficacy of triamcinolone acetonide topical solution (TTS) in dogs for use in reduction of clinical signs of pruritic inflammatory skin diseases of a known or suspected allergic basis and to evaluate adverse effects associated with TTS administration.ANIMALS: 103 pruritic adult dogs with kno... | [
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29626477 | Chronic cold exposure results in subcutaneous adipose tissue browning and altered global metabolism in Qinghai-Tibetan plateau pika (Ochotona curzoniae). | The plateau pika (Ochotona curzoniae), one of the indigenous animals of the Qinghai-Tibet Plateau, is adapted to life in a cold and hypoxic environment. We conducted a series of genomic, proteomic and morphological studies to investigate whether changes in energy metabolism contribute to adaptation of the plateau pika ... | [
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24273927 | Comparison of a rapid bed-side test with a central laboratory analysis for C-reactive protein in newborn infants with suspicion of sepsis. | BACKGROUND: Neonatal sepsis is one of the leading causes of neonatal morbidity and mortality in the newborn period. The purpose of this study was to compare a rapid bed-side test against central laboratory analysis for CRP in newborn infants with suspicion of sepsis.METHODS: We included 23 newborn infants with suspecte... | [
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20396920 | Mortality following emergency groin hernia surgery in Denmark. | PURPOSE: The mortality following emergency groin hernia repair in Denmark is more than twice as high (7%) as in comparable countries. This article describes in detail the population that died following emergency herniotomy in order to identify aspects of care that may improve outcome.METHODS: Patients > or =18 years of... | [
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23915429 | The impact of subgroup type and subgroup configurational properties on work team performance. | Scholars have invoked subgroups in a number of theories related to teams, yet certain tensions in the literature remain unresolved. In this article, we address 2 of these tensions, both relating to how subgroups are configured in work teams: (a) whether teams perform better with a greater number of subgroups and (b) wh... | [
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3083414 | Differential processing of RNA transcribed from the single-copy Drosophila myosin heavy chain gene produces four mRNAs that encode two polypeptides. | We report the sequence of genomic DNA at the 3' end of the single-copy Drosophila myosin heavy chain (MHC) gene and the structure and sequence at the 3' end of four MHC mRNAs. Two mRNAs, 7.2-kilobases (kb) and 8.0 kb in length, are expressed in all stages of development in which detectable levels of muscle-specific mRN... | [
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31606829 | Youth Parasympathetic Functioning Moderates Relations between Cumulative Family Risk and Internalizing Behaviors. | Problematic family functioning places young adolescents at risk for internalizing behaviors. However, not all adolescents who experience family risk develop internalizing behaviors during early adolescence. Informed by a cumulative risk perspective, the current study examined whether associations between cumulative fam... | [
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19495684 | Development and application of a dual-purpose nanoparticle platform for delivery and imaging of siRNA in tumors. | The vision of using a single therapeutic agent with sufficient generality to allow application to a wide variety of diseases, yet specific enough to permit intervention at single molecular stages of the pathology, is rapidly becoming a reality through the emergence of RNA interference. RNA interference can be used to i... | [
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19343923 | Micromorphology of resin/dentin interfaces using 4th and 5th generation dual-curing adhesive/cement systems: a confocal laser scanning microscope analysis. | PURPOSE: This study evaluated the differential composition of resin/dentin interfaces of indirect restorations created by the application of 4th and 5th generation dual-curing luting systems (bonding agents/resin cements), when each material was either light cured or allowed to self-cure.MATERIALS AND METHODS: Occlusal... | [
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12205081 | Crystal structure of the anticoagulant slow form of thrombin. | Using the thrombin mutant R77aA devoid of the site of autoproteolytic degradation at exosite I, we have solved for the first time the structure of thrombin free of any inhibitors and effector molecules and stabilized in the Na(+)-free slow form. The slow form shows subtle differences compared with the currently availab... | [
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10917694 | Viscosity and elasticity during collagen assembly in vitro: relevance to matrix-driven translocation. | In order to better understand the gelation process associated with collagen assembly, and the mechanism of the in vitro morphogenetic phenomenon of "matrix-driven translocation" [S.A. Newman et al. (1985) Science, 228, 885-889], the viscosity and elastic modulus of assembling collagen matrices in the presence and absen... | [
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26135075 | Surgical Treatments of Tumor-Induced Osteomalacia Lesions in Long Bones: Seventeen Cases with More Than One Year of Follow-up. | BACKGROUND: Tumor-induced osteomalacia is a rare and fascinating paraneoplastic syndrome usually caused by a small, benign phosphaturic mesenchymal tumor. Most tumors are treated surgically, but we are unaware of any reports that compare the results of curettage and segmental resection for lesions in long bones.METHODS... | [
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21861194 | Size, composition, and strength of ties of personal social support networks among adult people living with HIV/AIDS in Henan and Beijing, China. | To characterize the level of personal support available to people living with HIV/AIDS (PLWHA) in Henan and Beijing, China, face-to-face interviews were conducted to collect information on network size, composition, and strength of ties. The number of people as sources of support for participants in Henan varied from 1... | [
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25075105 | Efficacy and safety of irinotecan plus S-1 (IRIS) therapy to treat advanced/recurrent colorectal cancer. | BACKGROUND: 5-Fluorouracil (5-FU), leucovorin, and oxaliplatin (FOLFOX) therapy and 5-FU, leucovorin, and irinotecan (FOLFIRI) therapy are standard chemotherapies to treat advanced/recurrent colorectal cancer. However, these chemotherapies require continuous infusion of 5-FU for a prolonged time of 40 h or more, every ... | [
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29048317 | Non-normal data: Is ANOVA still a valid option? | BACKGROUND: The robustness of F-test to non-normality has been studied from the 1930s through to the present day. However, this extensive body of research has yielded contradictory results, there being evidence both for and against its robustness. This study provides a systematic examination of F-test robustness to vio... | [
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1904322 | Sequential renal alterations in septic shock in the primate. | This is a descriptive sequential study of the response of the baboon to LD100 Escherichia coli. The response was found to consist of three stages based on electron microscopic, physiologic, and clinical laboratory data. This study associates the inflammatory, coagulant, and cell injury (stage 1-3) responses with marker... | [
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6435795 | Which patients are cured of breast cancer? | The clinical and pathological features of 51 patients who survived for more than 20 years after diagnosis of cancer of the breast were compared with those of 176 contemporaries who died within 20 years after diagnosis. Of those who survived, 18 (35%) had had pathologically affected axillary nodes compared with at least... | [
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"Prognosis",
"Time Factors"
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25435203 | Securing the future of drug discovery for central nervous system disorders. | Innovative partnerships among researchers, patients, regulators, payors and industry are needed to reinvigorate drug discovery for central nervous system disorders. Here, we summarize plans of the Collegium Internationale Neuro-Psychopharmacologicum (CINP) to achieve this goal. | [
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"Central Nervous System Agents",
"Central Nervous System Diseases",
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} |
17183020 | Familial risks for nerve, nerve root and plexus disorders in siblings based on hospitalisations in Sweden. | BACKGROUND: Nerve, nerve root and plexus disorders are common diseases, but little is known about familial clustering in these diseases. This is, to our knowledge, the first systematic family study carried out on these diseases.METHODS: Familial risks for siblings who were hospitalised for nerve, nerve root and plexus ... | [
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17470556 | Fluorescence resonance energy transfer analysis of recombination signal sequence configuration in the RAG1/2 synaptic complex. | A critical step in V(D)J recombination is the synapsis of complementary (12/23) recombination signal sequences (RSSs) by the RAG1 and RAG2 proteins to generate the paired complex (PC). Using a facilitated ligation assay and substrates that vary the helical phasing of the RSSs, we provide evidence that one particular ge... | [
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"Animals",
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"Chromosome Pairing",
"Energy Transfer",
"Fluorescence Resonance Energy Transfer",
"Fluorescent Dyes",
"Homeodomain Proteins",
"Mice",
"Models, Biological",
"Nuclear Proteins",
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24710388 | A dark-field light scattering platform for real-time monitoring of the erosion of microparticles by Co2+. | Monitoring chemical reactions using tools of analytical chemistry is crucial for understanding the mechanisms of these reactions. In this study, leaf-like poly(p-phenylenediamine) (PpPD) microparticles were prepared with precisely tailored properties. The dark field microscopy protocol proved to be a powerful tool for ... | [
12162,
426,
1155,
59,
1481
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2557222 | Inhibition of cisplatin-induced emesis in the pigeon by a non-psychotropic synthetic cannabinoid. | The (+) enantiomer of the synthetic cannabinoid, 7-hydroxy-delta-6-tetrahydrocannabinol, dimethylheptyl homolog (HU-211), possesses significant antimetic efficacy in the pigeon. However, unlike all anti-emetic cannabinoids tested in the past, it is devoid of psychotropic (cannabimimetic) activity. The anti-emetic activ... | [
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1449,
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1317,
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"Cisplatin",
"Columbidae",
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} |
6511145 | Effect of phosphonium salts and phosphoranes on the acetylcholinesterase activity and on the viability of Schistosoma mansoni parasites. | In this study we investigated the effects of a series of phosphonium salts and phosphoranes on the catalytic activity of acetylcholinesterase and on the viability of the various life stages of Schistosoma mansoni worms. All the tested compounds showed an inhibitory effect towards the S. mansoni acetylcholinesterase (AC... | [
1101,
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36,
447,
1806,
16872,
1619,
4724,
8607,
4726,
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"Mice, Inbred ICR",
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"Schistosoma mansoni",
"Schistosomiasis",
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22552838 | A randomised trial of a weight loss intervention for overweight and obese people diagnosed with coronary heart disease and/or type 2 diabetes. | BACKGROUND: Weight reduction limits disease progression in obese people with coronary heart disease (CHD) and/or type 2 diabetes mellitus (T2DM).PURPOSE: To test a 16-week group-based weight reduction intervention combining exercise, diet and behaviour change strategies aimed to increase self-efficacy (Healthy Eating a... | [
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2391418 | C1q receptor on murine cells. | Different cells and cell lines of murine origin were tested for their capacity to bind the C subcomponent C1q by using biotinylated human C1q and streptavidin-FITC. Cytofluorometric analysis of splenocytes and thymocytes shows that the majority of C1q-reactive cells reside in the population of B cells and macrophages. ... | [
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8698397 | Flow cytometric analysis of cytokine receptors on human Langerhans' cells. Changes observed after short-term culture. | It is well established that granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-1 and tumour necrosis factor-alpha (TNF-alpha) are involved in Langerhans' cell (LC) development and dendritic cell traffic. However, little is known about the pattern of cytokine receptors on human LC and their modu... | [
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305,
5651,
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"Antibodies, Monoclonal",
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"Flow Cytometry",
"Humans",
"Kinetics",
"Langerhans Cells",
"Receptors, Cytokine",
"Receptors, Granulocyte-Macrophage Colony-Stimulating Factor",
"Receptors, Interferon",
"Receptors, Interleukin",
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] | {
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