query_id stringlengths 1 4 | query stringlengths 26 249 | positive_passages listlengths 1 5 | negative_passages listlengths 16 20 |
|---|---|---|---|
1398 | p16INK4A degradation is encoded by CDKN2A. | [
{
"docid": "17717391",
"title": "Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model",
"text": "Monitoring cancer and aging in vivo remains experimentally challenging. Here, we describe a luciferase knockin mouse (p16(LUC)), which faithfully reports expression of p16(INK4a),... | [
{
"docid": "19343151",
"title": "p16INK4A is a robust in vivo biomarker of cellular aging in human skin.",
"text": "The cell-cycle regulating gene, p16INK4A, encoding an inhibitor of cyclin-dependent kinases 4 and 6, is considered to play an important role in cellular aging and in premature senescence. ... |
1400 | p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain | [
{
"docid": "14706752",
"title": "Gamma-Secretase Represents a Therapeutic Target for the Treatment of Invasive Glioma Mediated by the p75 Neurotrophin Receptor",
"text": "The multifunctional signaling protein p75 neurotrophin receptor (p75(NTR)) is a central regulator and major contributor to the highly... | [
{
"docid": "368506",
"title": "Generation of mice with a conditional allele for the p75(NTR) neurotrophin receptor gene.",
"text": "The p75(NTR) neurotrophin receptor has been implicated in multiple biological and pathological processes. While significant advances have recently been made in understandin... |
1401 | qSOFA scores are associated with length of stay in emergency department patients. | [
{
"docid": "5185871",
"title": "Prognostic Accuracy of the SOFA Score, SIRS Criteria, and qSOFA Score for In-Hospital Mortality Among Adults With Suspected Infection Admitted to the Intensive Care Unit",
"text": "Importance The Sepsis-3 Criteria emphasized the value of a change of 2 or more points in th... | [
{
"docid": "34208005",
"title": "Ethical dilemmas in a randomized trial of asthma treatment: can Bayesian statistical analysis explain the results?",
"text": "OBJECTIVES The original objective was to determine whether the use of bilevel positive airway pressure (BiPAP) ventilation would reduce the need ... |
1402 | r-protein chaperones are found in complexes with their r-protein binding partners. | [
{
"docid": "8126244",
"title": "Rational Extension of the Ribosome Biogenesis Pathway Using Network-Guided Genetics",
"text": "Biogenesis of ribosomes is an essential cellular process conserved across all eukaryotes and is known to require >170 genes for the assembly, modification, and trafficking of ri... | [
{
"docid": "8677721",
"title": "NDRG1 promotes growth of hepatocellular carcinoma cells by directly interacting with GSK-3β and Nur77 to prevent β-catenin degradation",
"text": "The N-myc downstream regulated gene 1 (NDRG1) is significantly associated with advanced tumor stages and poor survival of hepa... |
1403 | siRNA knockdown of A20 accelerates tumor progression in an in vivo murine xenograft model. | [
{
"docid": "33370",
"title": "Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth",
"text": "Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioblastoma stem cells (GSCs). GSCs are regulated by molecular pathways distinct from the... | [
{
"docid": "33638477",
"title": "BCL9 promotes tumor progression by conferring enhanced proliferative, metastatic, and angiogenic properties to cancer cells.",
"text": "Several components of the Wnt signaling cascade have been shown to function either as tumor suppressor proteins or as oncogenes in mult... |
1404 | siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model. | [
{
"docid": "33370",
"title": "Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth",
"text": "Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioblastoma stem cells (GSCs). GSCs are regulated by molecular pathways distinct from the... | [
{
"docid": "33638477",
"title": "BCL9 promotes tumor progression by conferring enhanced proliferative, metastatic, and angiogenic properties to cancer cells.",
"text": "Several components of the Wnt signaling cascade have been shown to function either as tumor suppressor proteins or as oncogenes in mult... |
1405 | taa1 tar1 tar2 triple mutants in Arabidopsis do not make root meristem during embryogenesis. | [
{
"docid": "10504681",
"title": "TAA1-Mediated Auxin Biosynthesis Is Essential for Hormone Crosstalk and Plant Development",
"text": "Plants have evolved a tremendous ability to respond to environmental changes by adapting their growth and development. The interaction between hormonal and developmental ... | [
{
"docid": "20402596",
"title": "The WUSCHEL-related homeobox gene WOX11 is required to activate shoot-borne crown root development in rice.",
"text": "In rice (Oryza sativa), the shoot-borne crown roots are the major root type and are initiated at lower stem nodes as part of normal plant development. H... |
1406 | β-sheet opening occurs during pleurotolysin pore formation. | [
{
"docid": "2617858",
"title": "Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin",
"text": "Membrane attack complex/perforin-like (MACPF) proteins comprise the largest superfamily of pore-forming proteins, playing crucial roles in immunity and pathogenesis. Solu... | [
{
"docid": "14362678",
"title": "CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation",
"text": "Mitochondrial permeability transition pore (mPTP) is involved in cardiac dysfunction during chronic β-adrenergic receptor (β-AR) stimulation. The mechanism by w... |
1407 | β1/Ketel is able to bind microtubules. | [
{
"docid": "8087082",
"title": "A Microtubule Interactome: Complexes with Roles in Cell Cycle and Mitosis",
"text": "The microtubule (MT) cytoskeleton is required for many aspects of cell function, including the transport of intracellular materials, the maintenance of cell polarity, and the regulation o... | [
{
"docid": "11200685",
"title": "Integrins regulate microtubule nucleating activity of centrosome through mitogen-activated protein kinase/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase (MEK/ERK) signaling.",
"text": "Microtubule nucleation is an essential step in the... |
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