query_id stringlengths 1 4 | query stringlengths 26 249 | positive_passages listlengths 1 5 | negative_passages listlengths 16 20 |
|---|---|---|---|
1037 | Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells. | [
{
"docid": "16287725",
"title": "Reprogramming of human fibroblasts to pluripotency with lineage specifiers.",
"text": "Since the initial discovery that OCT4, SOX2, KLF4, and c-MYC overexpression sufficed for the induction of pluripotency in somatic cells, methodologies replacing the original factors ha... | [
{
"docid": "6054657",
"title": "Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency.",
"text": "Transcription factor-based cellular reprogramming has opened the way to converting somatic cells to a pluripotent state, but has faced limitations resulting from the... |
1038 | Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells. | [
{
"docid": "16287725",
"title": "Reprogramming of human fibroblasts to pluripotency with lineage specifiers.",
"text": "Since the initial discovery that OCT4, SOX2, KLF4, and c-MYC overexpression sufficed for the induction of pluripotency in somatic cells, methodologies replacing the original factors ha... | [
{
"docid": "1630949",
"title": "Oct4-Induced Pluripotency in Adult Neural Stem Cells",
"text": "The four transcription factors Oct4, Sox2, Klf4, and c-Myc can induce pluripotency in mouse and human fibroblasts. We previously described direct reprogramming of adult mouse neural stem cells (NSCs) by Oct4 ... |
1040 | Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes. | [
{
"docid": "25254425",
"title": "Nucleosome stability mediated by histone variants H3.3 and H2A.Z.",
"text": "Nucleosomes containing the histone variant H3.3 tend to be clustered in vivo in the neighborhood of transcriptionally active genes and over regulatory elements. It has not been clear, however, w... | [
{
"docid": "9451052",
"title": "Stepwise Histone Replacement by SWR1 Requires Dual Activation with Histone H2A.Z and Canonical Nucleosome",
"text": "Histone variant H2A.Z-containing nucleosomes are incorporated at most eukaryotic promoters. This incorporation is mediated by the conserved SWR1 complex, w... |
1042 | Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression. | [
{
"docid": "17421851",
"title": "Expression of interleukin-18 in human atherosclerotic plaques and relation to plaque instability.",
"text": "BACKGROUND Interleukin (IL)-18 is a potent proinflammatory cytokine with potential atherogenic properties. Its expression and role in atherosclerosis, however, ar... | [
{
"docid": "7711685",
"title": "Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions.",
"text": "This review will reconsider the current paradigm for understanding the critical, final steps in the progression of atherosclerotic lesions. That... |
1043 | Retinoic acid receptor-related orphan receptor gamma (RORγ) is a therapeutic target for castration-resistant prostate cancer (CRPC) | [
{
"docid": "17671145",
"title": "ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer",
"text": "The androgen receptor (AR) is overexpressed and hyperactivated in human castration-resistant prostate cancer (CRPC). However, the determinants... | [
{
"docid": "14116046",
"title": "Retinoic acid-related orphan receptors α and γ: key regulators of lipid/glucose metabolism, inflammation, and insulin sensitivity",
"text": "Retinoic acid-related orphan receptors RORα and RORγ play a regulatory role in lipid/glucose homeostasis and various immune functi... |
1044 | Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis. | [
{
"docid": "22500262",
"title": "Cryptochrome Mediates Circadian Regulation of cAMP Signaling and Hepatic Gluconeogenesis",
"text": "During fasting, mammals maintain normal glucose homeostasis by stimulating hepatic gluconeogenesis. Elevations in circulating glucagon and epinephrine, two hormones that a... | [
{
"docid": "11565780",
"title": "Circadian regulation of intracellular G-protein signalling mediates intercellular synchrony and rhythmicity in the suprachiasmatic nucleus",
"text": "Synchronous oscillations of thousands of cellular clocks in the suprachiasmatic nucleus (SCN), the circadian centre, are ... |
1045 | Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism. | [
{
"docid": "22500262",
"title": "Cryptochrome Mediates Circadian Regulation of cAMP Signaling and Hepatic Gluconeogenesis",
"text": "During fasting, mammals maintain normal glucose homeostasis by stimulating hepatic gluconeogenesis. Elevations in circulating glucagon and epinephrine, two hormones that a... | [
{
"docid": "11565780",
"title": "Circadian regulation of intracellular G-protein signalling mediates intercellular synchrony and rhythmicity in the suprachiasmatic nucleus",
"text": "Synchronous oscillations of thousands of cellular clocks in the suprachiasmatic nucleus (SCN), the circadian centre, are ... |
1046 | Ribosomal protein (RP) expression is controlled in part by stress-activated regulators. | [
{
"docid": "418246",
"title": "Pathway connectivity and signaling coordination in the yeast stress-activated signaling network",
"text": "Stressed cells coordinate a multi-faceted response spanning many levels of physiology. Yet knowledge of the complete stress-activated regulatory network as well as de... | [
{
"docid": "12486491",
"title": "Ribosome-Mediated Specificity in Hox mRNA Translation and Vertebrate Tissue Patterning",
"text": "Historically, the ribosome has been viewed as a complex ribozyme with constitutive rather than regulatory capacity in mRNA translation. Here we identify mutations of the Rib... |
1047 | Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain | [
{
"docid": "14706752",
"title": "Gamma-Secretase Represents a Therapeutic Target for the Treatment of Invasive Glioma Mediated by the p75 Neurotrophin Receptor",
"text": "The multifunctional signaling protein p75 neurotrophin receptor (p75(NTR)) is a central regulator and major contributor to the highly... | [
{
"docid": "368506",
"title": "Generation of mice with a conditional allele for the p75(NTR) neurotrophin receptor gene.",
"text": "The p75(NTR) neurotrophin receptor has been implicated in multiple biological and pathological processes. While significant advances have recently been made in understandin... |
1048 | Ribosomopathies have a high degree of cell and tissue specific pathology. | [
{
"docid": "12486491",
"title": "Ribosome-Mediated Specificity in Hox mRNA Translation and Vertebrate Tissue Patterning",
"text": "Historically, the ribosome has been viewed as a complex ribozyme with constitutive rather than regulatory capacity in mRNA translation. Here we identify mutations of the Rib... | [
{
"docid": "24737389",
"title": "Growth control and ribosomopathies.",
"text": "Ribosome biogenesis and protein synthesis are two of the most energy consuming processes in a growing cell. Moreover, defects in their molecular components can alter the pattern of gene expression. Thus it is understandable ... |
1050 | Risedronate increases risk of vertebral and non-vertebral fractures. | [
{
"docid": "19878070",
"title": "Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Vertebral Efficacy With Risedronate Therapy (VERT) Study Group.",
"text": "CONTEXT Risedronate, a potent bisphosphonate, has... | [
{
"docid": "26000593",
"title": "Effect of osteoporosis treatments on risk of non-vertebral fractures: review and meta-analysis of intention-to-treat studies",
"text": "Most osteoporosis treatments have proven efficacy in reducing the risk of vertebral fractures, whereas evidence is less straightforward... |
1052 | Rising temperatures caused by global warming increases risk of dengue fever transmission. | [
{
"docid": "18816720",
"title": "Spatial and Temporal Clustering of Dengue Virus Transmission in Thai Villages",
"text": "BACKGROUND Transmission of dengue viruses (DENV), the leading cause of arboviral disease worldwide, is known to vary through time and space, likely owing to a combination of factors ... | [
{
"docid": "2097256",
"title": "Population Density, Water Supply, and the Risk of Dengue Fever in Vietnam: Cohort Study and Spatial Analysis",
"text": "BACKGROUND Aedes aegypti, the major vector of dengue viruses, often breeds in water storage containers used by households without tap water supply, and ... |
1053 | Rising temperatures caused by global warming lowers the risk of dengue fever transmission. | [
{
"docid": "18816720",
"title": "Spatial and Temporal Clustering of Dengue Virus Transmission in Thai Villages",
"text": "BACKGROUND Transmission of dengue viruses (DENV), the leading cause of arboviral disease worldwide, is known to vary through time and space, likely owing to a combination of factors ... | [
{
"docid": "2097256",
"title": "Population Density, Water Supply, and the Risk of Dengue Fever in Vietnam: Cohort Study and Spatial Analysis",
"text": "BACKGROUND Aedes aegypti, the major vector of dengue viruses, often breeds in water storage containers used by households without tap water supply, and ... |
1054 | Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients. | [
{
"docid": "10072941",
"title": "Cardiovascular protection with antihypertensive drugs in dialysis patients: systematic review and meta-analysis.",
"text": "Epidemiological studies demonstrate that a lower blood pressure and decline in blood pressure over months or years are associated with higher morta... | [
{
"docid": "40790033",
"title": "Renal outcomes with different fixed-dose combination therapies in patients with hypertension at high risk for cardiovascular events (ACCOMPLISH): a prespecified secondary analysis of a randomised controlled trial.",
"text": "BACKGROUND The Avoiding Cardiovascular Events ... |
1055 | Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals. | [
{
"docid": "13906581",
"title": "Patient Outcomes with Teaching Versus Nonteaching Healthcare: A Systematic Review",
"text": "Background Extensive debate exists in the healthcare community over whether outcomes of medical care at teaching hospitals and other healthcare units are better or worse than th... | [
{
"docid": "20746604",
"title": "The effectiveness of right heart catheterization in the initial care of critically ill patients. SUPPORT Investigators.",
"text": "OBJECTIVE To examine the association between the use of right heart catheterization (RHC) during the first 24 hours of care in the intensive... |
1056 | Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder. | [
{
"docid": "4200695",
"title": "Effect of specific exercise strategy on need for surgery in patients with subacromial impingement syndrome: randomised controlled study",
"text": "OBJECTIVE To evaluate if a specific exercise strategy, targeting the rotator cuff and scapula stabilisers, improves shoulder ... | [
{
"docid": "38493521",
"title": "Corticosteroid injections for shoulder pain.",
"text": "BACKGROUND While many treatments, including corticosteroid injections in and around the shoulder, are advocated to be of benefit for shoulder pain, few are of proven efficacy. This review of corticosteroid injection... |
1058 | Roughly 55% of women with chronic pelvic pain have no underlying pathology. | [
{
"docid": "13027590",
"title": "Laparoscopic uterosacral nerve ablation for alleviating chronic pelvic pain: a randomized controlled trial.",
"text": "CONTEXT Chronic pelvic pain is a common condition with a major effect on health-related quality of life, work productivity, and health care use. Operati... | [
{
"docid": "32462603",
"title": "Epidemiology of surgically managed pelvic organ prolapse and urinary incontinence.",
"text": "OBJECTIVE To determine the incidence of surgically managed pelvic organ prolapse and urinary incontinence in a population-based cohort, and to describe their clinical characteri... |
1065 | Satellite cell dysfunction is a key factor in sarcopenia development. | [
{
"docid": "20418809",
"title": "Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia",
"text": "A key determinant of geriatric frailty is sarcopenia, the age-associated loss of skeletal muscle mass and strength. Although the e... | [
{
"docid": "25419778",
"title": "Identification of Senescent Cells in the Bone Microenvironment.",
"text": "Cellular senescence is a fundamental mechanism by which cells remain metabolically active yet cease dividing and undergo distinct phenotypic alterations, including upregulation of p16Ink4a , profo... |
1067 | ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA. | [
{
"docid": "4429668",
"title": "Pif1 family helicases suppress genome instability at G-quadruplex motifs",
"text": "The Saccharomyces cerevisiae Pif1 helicase is the prototypical member of the Pif1 DNA helicase family, which is conserved from bacteria to humans. Here we show that exceptionally potent G-... | [
{
"docid": "16217855",
"title": "The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA",
"text": "The product of the gene mutated in Bloom's syndrome, BLM, is a 3′–5′ DNA helicase belonging to the highly conserved RecQ family. In addition to a conventional DNA strand ... |
1068 | ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA. | [
{
"docid": "4429668",
"title": "Pif1 family helicases suppress genome instability at G-quadruplex motifs",
"text": "The Saccharomyces cerevisiae Pif1 helicase is the prototypical member of the Pif1 DNA helicase family, which is conserved from bacteria to humans. Here we show that exceptionally potent G-... | [
{
"docid": "16217855",
"title": "The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA",
"text": "The product of the gene mutated in Bloom's syndrome, BLM, is a 3′–5′ DNA helicase belonging to the highly conserved RecQ family. In addition to a conventional DNA strand ... |
1069 | Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder. | [
{
"docid": "4200695",
"title": "Effect of specific exercise strategy on need for surgery in patients with subacromial impingement syndrome: randomised controlled study",
"text": "OBJECTIVE To evaluate if a specific exercise strategy, targeting the rotator cuff and scapula stabilisers, improves shoulder ... | [
{
"docid": "53779698",
"title": "Exercise as a therapeutic approach to improve blood pressure in patients with peripheral arterial disease: current literature and future directions.",
"text": "INTRODUCTION Patients with symptomatic peripheral artery disease (PAD) exhibit reduced functional capacity and ... |
1070 | Self-advocacy training is effective at decreasing homelessness. | [
{
"docid": "25649714",
"title": "Mental health problems of homeless children and families: longitudinal study.",
"text": "OBJECTIVE To establish the mental health needs of homeless children and families before and after rehousing. \n DESIGN Cross sectional, longitudinal study. \n SETTING City of Bir... | [
{
"docid": "6129301",
"title": "Evaluation of a mental health outreach service for homeless families.",
"text": "AIMS To describe the characteristics of homeless children and families seen by the mental health outreach service (MHOS), to evaluate the impact of this service on the short term psychosocial... |
1072 | Sepsis related mortality has remained stable between 2009-2014. | [
{
"docid": "4824840",
"title": "Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014",
"text": "Importance Estimates from claims-based analyses suggest that the incidence of sepsis is increasing and mortality rates from sepsis are decreasing. However, estimates from cl... | [
{
"docid": "4791384",
"title": "Neonatal Mortality Levels for 193 Countries in 2009 with Trends since 1990: A Systematic Analysis of Progress, Projections, and Priorities",
"text": "BACKGROUND Historically, the main focus of studies of childhood mortality has been the infant and under-five mortality rat... |
1073 | Sepsis related mortality has risen from 2009 to 2014. | [
{
"docid": "4824840",
"title": "Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014",
"text": "Importance Estimates from claims-based analyses suggest that the incidence of sepsis is increasing and mortality rates from sepsis are decreasing. However, estimates from cl... | [
{
"docid": "5596332",
"title": "The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).",
"text": "IMPORTANCE Definitions of sepsis and septic shock were last revised in 2001. Considerable advances have since been made into the pathobiology (changes in organ function, morph... |
1074 | Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality. | [
{
"docid": "14658685",
"title": "Enhancer Evolution across 20 Mammalian Species",
"text": "The mammalian radiation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehensive understanding of regulatory evolution in mammals. Here, we track the evolution of promote... | [
{
"docid": "3823862",
"title": "Integrated maps in quail (Coturnix japonica) confirm the high degree of synteny conservation with chicken (Gallus gallus) despite 35 million years of divergence",
"text": "BackgroundBy comparing the quail genome with that of chicken, chromosome rearrangements that have oc... |
1075 | Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality. | [
{
"docid": "14658685",
"title": "Enhancer Evolution across 20 Mammalian Species",
"text": "The mammalian radiation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehensive understanding of regulatory evolution in mammals. Here, we track the evolution of promote... | [
{
"docid": "3823862",
"title": "Integrated maps in quail (Coturnix japonica) confirm the high degree of synteny conservation with chicken (Gallus gallus) despite 35 million years of divergence",
"text": "BackgroundBy comparing the quail genome with that of chicken, chromosome rearrangements that have oc... |
1081 | Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women. | [
{
"docid": "5691302",
"title": "Antidepressant use and risk of adverse outcomes in older people: population based cohort study",
"text": "OBJECTIVES To investigate the association between antidepressant treatment and risk of several potential adverse outcomes in older people with depression and to exami... | [
{
"docid": "16701509",
"title": "Serum high-density lipoprotein cholesterol, metabolic profile, and breast cancer risk.",
"text": "BACKGROUND The prevalence of metabolic syndrome (obesity, glucose intolerance, low serum high-density lipoprotein cholesterol [HDL-C], high serum triglycerides, hypertension... |
1084 | Side effects associated with antidepressants increases risk of stroke. | [
{
"docid": "5691302",
"title": "Antidepressant use and risk of adverse outcomes in older people: population based cohort study",
"text": "OBJECTIVES To investigate the association between antidepressant treatment and risk of several potential adverse outcomes in older people with depression and to exami... | [
{
"docid": "24494539",
"title": "[Acupuncture combined with auricular point sticking therapy for post stroke depression:a randomized controlled trial].",
"text": "OBJECTIVE To observe the clinical effects of acupuncture combined with auricular point sticking based on the western medication for post stro... |
1085 | Side effects associated with antidepressants lower risk of myocardial infarction. | [
{
"docid": "5691302",
"title": "Antidepressant use and risk of adverse outcomes in older people: population based cohort study",
"text": "OBJECTIVES To investigate the association between antidepressant treatment and risk of several potential adverse outcomes in older people with depression and to exami... | [
{
"docid": "32159283",
"title": "Antibiotics and risk of subsequent first-time acute myocardial infarction.",
"text": "CONTEXT Increasing evidence supports the hypothesis of a causal association between certain bacterial infections and increased risk of developing acute myocardial infarction. If such a ... |
1087 | Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants. | [
{
"docid": "39281140",
"title": "Treatment of antidepressant-associated sexual dysfunction with sildenafil: a randomized controlled trial.",
"text": "CONTEXT Sexual dysfunction is a common adverse effect of antidepressants that frequently results in treatment noncompliance. \n OBJECTIVE To assess the ... | [
{
"docid": "3981244",
"title": "Psychobiological Protective Factors Modifying the Association Between Age and Sexual Health in Men: Findings From the Men’s Health 40+ Study",
"text": "Sexual health severely decreases with age. For males older than 40 years, erectile dysfunction (ED) is the most common s... |
1090 | Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding. | [
{
"docid": "17628888",
"title": "ATPase-Dependent Control of the Mms21 SUMO Ligase during DNA Repair",
"text": "Modification of proteins by SUMO is essential for the maintenance of genome integrity. During DNA replication, the Mms21-branch of the SUMO pathway counteracts recombination intermediates at d... | [
{
"docid": "7915836",
"title": "The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins",
"text": "Most cancer cells activate telomerase to elongate telomeres and achieve unlimited replicative potential. Some cancer cells cannot activate telomera... |
1091 | Sn is present on mature DCs during inflammation in vivo. | [
{
"docid": "2603304",
"title": "Siglec-1 Is a Novel Dendritic Cell Receptor That Mediates HIV-1 Trans-Infection Through Recognition of Viral Membrane Gangliosides",
"text": "Dendritic cells (DCs) are essential antigen-presenting cells for the induction of immunity against pathogens. However, HIV-1 sprea... | [
{
"docid": "40365566",
"title": "Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen.",
"text": "Dendritic cells (DCs) are crucial for mounting allergic airway inflammation, but it is unclear which subset of DCs p... |
1096 | Specialized functional cell types can be derived from human pluripotent stem cells. | [
{
"docid": "29638116",
"title": "Complex Tissue and Disease Modeling using hiPSCs.",
"text": "Defined genetic models based on human pluripotent stem cells have opened new avenues for understanding disease mechanisms and drug screening. Many of these models assume cell-autonomous mechanisms of disease bu... | [
{
"docid": "4784069",
"title": "Regulatory principles of pluripotency: from the ground state up.",
"text": "Pluripotency is the remarkable capacity of a single cell to engender all the specialized cell types of an adult organism. This property can be captured indefinitely through derivation of self-rene... |
1097 | Splenomegaly is observed in knockin mouse lacking the SHP-2 MAPK pathway. | [
{
"docid": "26851674",
"title": "Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses.",
"text": "We generated a series of knockin mouse lines, in which the cytokine receptor gp130-dependent STAT3 and/or SHP2 signals were disru... | [
{
"docid": "18038250",
"title": "Control of CNS Cell-Fate Decisions by SHP-2 and Its Dysregulation in Noonan Syndrome",
"text": "Within the developing mammalian CNS, growth factors direct multipotent precursors to generate neurons versus glia, a process that if perturbed might lead to neural dysfunction... |
1098 | Stacking is more stable when a purine is present in the +5 position (C1698). | [
{
"docid": "13552682",
"title": "Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes",
"text": "In eukaryotes, accurate protein synthesis relies on a family of translational GTPases that pair with specific decoding factors to decipher the mRNA code on ribosomes. We present structur... | [
{
"docid": "410286",
"title": "TECHNICAL ADVANCE Floral dip: a simplified method for Agrobacterium-mediated",
"text": "The Agrobacterium vacuum infiltration method has made it possible to transform Arabidopsis thaliana without plant tissue culture or regeneration. In the present study, this method was e... |
1101 | Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner. | [
{
"docid": "3874000",
"title": "Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation.",
"text": "Regenerative medicine is predicated on understanding the mechanisms regulating development and applying these conditions to direct stem cell fate. Embryogenesis is guided by c... | [
{
"docid": "43661837",
"title": "Defining early lineage specification of human embryonic stem cells by the orchestrated balance of canonical Wnt/beta-catenin, Activin/Nodal and BMP signaling.",
"text": "The canonical Wnt/beta-catenin signaling has remarkably diverse roles in embryonic development, stem ... |
1102 | Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner. | [
{
"docid": "3874000",
"title": "Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation.",
"text": "Regenerative medicine is predicated on understanding the mechanisms regulating development and applying these conditions to direct stem cell fate. Embryogenesis is guided by c... | [
{
"docid": "13779605",
"title": "Identification of vitronectin as an extrinsic inducer of cancer stem cell differentiation and tumor formation.",
"text": "There is mounting evidence that tumors are initiated by a rare subset of cells called cancer stem cells (CSCs). CSCs are generally quiescent, self-re... |
1103 | Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin. | [
{
"docid": "3898784",
"title": "Association of Intracerebral Hemorrhage Among Patients Taking Non–Vitamin K Antagonist vs Vitamin K Antagonist Oral Anticoagulants With In-Hospital Mortality",
"text": "Importance Although non–vitamin K antagonist oral anticoagulants (NOACs) are increasingly used to preve... | [
{
"docid": "5884524",
"title": "Impact of diabetes on long-term prognosis in patients with unstable angina and non-Q-wave myocardial infarction: results of the OASIS (Organization to Assess Strategies for Ischemic Syndromes) Registry.",
"text": "BACKGROUND Although unstable coronary artery disease is th... |
1105 | Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers. | [
{
"docid": "6710713",
"title": "Risk factors at medical school for subsequent professional misconduct: multicentre retrospective case-control study",
"text": "OBJECTIVE To determine whether there are risk factors in a doctor's time at medical school that are associated with subsequent professional misco... | [
{
"docid": "17374970",
"title": "Predictors of Attrition and Academic Success of Medical Students: A 30-Year Retrospective Study",
"text": "AIM To determine attrition and predictors of academic success among medical students at University of Split, Croatia. \n METHODS We analysed academic records of 2... |
1106 | Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers. | [
{
"docid": "6710713",
"title": "Risk factors at medical school for subsequent professional misconduct: multicentre retrospective case-control study",
"text": "OBJECTIVE To determine whether there are risk factors in a doctor's time at medical school that are associated with subsequent professional misco... | [
{
"docid": "17374970",
"title": "Predictors of Attrition and Academic Success of Medical Students: A 30-Year Retrospective Study",
"text": "AIM To determine attrition and predictors of academic success among medical students at University of Split, Croatia. \n METHODS We analysed academic records of 2... |
1109 | Suboptimal nutrition is a leading cause of premature death | [
{
"docid": "13770184",
"title": "Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015",
"text": "BACKGROUND The Global Burden of... | [
{
"docid": "4313478",
"title": "Translational control of intron splicing in eukaryotes",
"text": "Most eukaryotic genes are interrupted by non-coding introns that must be accurately removed from pre-messenger RNAs to produce translatable mRNAs. Splicing is guided locally by short conserved sequences, bu... |
1111 | Sudden death can occur in patients with complex ventricular arrhythmias. | [
{
"docid": "1686881",
"title": "Myocardial muscarinic receptor upregulation and normal response to isoproterenol in denervated hearts by familial amyloid polyneuropathy.",
"text": "BACKGROUND Patients with familial amyloid polyneuropathy, a rare hereditary form of amyloidosis, have progressive autonomic... | [
{
"docid": "2032877",
"title": "Predicting mortality of patients hospitalized for acutely exacerbated chronic obstructive pulmonary disease.",
"text": "PURPOSE To identify factors affecting the short-term prognosis of patients with acutely exacerbated chronic obstructive pulmonary disease (COPD). \n P... |
1112 | Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities. | [
{
"docid": "1686881",
"title": "Myocardial muscarinic receptor upregulation and normal response to isoproterenol in denervated hearts by familial amyloid polyneuropathy.",
"text": "BACKGROUND Patients with familial amyloid polyneuropathy, a rare hereditary form of amyloidosis, have progressive autonomic... | [
{
"docid": "35521287",
"title": "Cardiorespiratory adaptation during sleep in infants and children.",
"text": "The cardiorespiratory control system undergoes functional maturation after birth. Until this process is completed, the cardiorespiratory system is unstable, placing infants at risk for cardiore... |
1114 | Surfactin producing cells and exopolymer producing cells cooperate to generate "Van Gogh" bundles that have sliding abilities on specialized media. | [
{
"docid": "12824568",
"title": "From Cell Differentiation to Cell Collectives: Bacillus subtilis Uses Division of Labor to Migrate",
"text": "The organization of cells, emerging from cell-cell interactions, can give rise to collective properties. These properties are adaptive when together cells can fa... | [
{
"docid": "4423559",
"title": "Planar cell polarity signalling couples cell division and morphogenesis during neurulation",
"text": "Environmental and genetic aberrations lead to neural tube closure defects (NTDs) in 1 out of every 1,000 births. Mouse and frog models for these birth defects have indica... |
1115 | Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus. | [
{
"docid": "44048701",
"title": "Surgical vs nonsurgical treatment of adults with displaced fractures of the proximal humerus: the PROFHER randomized clinical trial.",
"text": "IMPORTANCE The need for surgery for the majority of patients with displaced proximal humeral fractures is unclear, but its use ... | [
{
"docid": "19182166",
"title": "Internal fixation versus nonoperative treatment of displaced 3-part proximal humeral fractures in elderly patients: a randomized controlled trial.",
"text": "BACKGROUND The aim of the study was to report the 2-year outcome after a displaced 3-part fracture of the proxima... |
1118 | Sweet taste receptors on the tongue are deactivated by between 1 and 10 mM glucose. | [
{
"docid": "23351136",
"title": "Detection of sweet and umami taste in the absence of taste receptor T1r3.",
"text": "The tastes of sugars (sweet) and glutamate (umami) are thought to be detected by T1r receptors expressed in taste cells. Molecular genetics and heterologous expression implicate T1r2 plu... | [
{
"docid": "20829129",
"title": "Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.",
"text": "Glucagon-like peptide-1 (GLP-1), released from gut endocrine L cells in response to glucose, regulates appetite, insulin secretion, and gut motility. How glucose given o... |
1119 | Sympathetic nerve activity is elevated throughout normal pregnancy. | [
{
"docid": "5323845",
"title": "Sympathetic neural mechanisms in normal and hypertensive pregnancy in humans.",
"text": "BACKGROUND Direct recordings from peripheral sympathetic nerves have shown an increased sympathetic drive in pregnancy-induced hypertension (PIH) and preeclampsia (PE). It is unknown ... | [
{
"docid": "26710772",
"title": "Sympathetic activation during early pregnancy in humans.",
"text": "Sympathetic activity has been reported to increase in normotensive pregnant women, and to be even greater in women with gestational hypertension and preeclampsia at term. Whether sympathetic overactivity... |
1120 | Sympathetic nerve activity is reduced throughout normal pregnancy. | [
{
"docid": "5323845",
"title": "Sympathetic neural mechanisms in normal and hypertensive pregnancy in humans.",
"text": "BACKGROUND Direct recordings from peripheral sympathetic nerves have shown an increased sympathetic drive in pregnancy-induced hypertension (PIH) and preeclampsia (PE). It is unknown ... | [
{
"docid": "26710772",
"title": "Sympathetic activation during early pregnancy in humans.",
"text": "Sympathetic activity has been reported to increase in normotensive pregnant women, and to be even greater in women with gestational hypertension and preeclampsia at term. Whether sympathetic overactivity... |
1125 | Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED) | [
{
"docid": "21009874",
"title": "Overall and cancer related mortality among patients with ocular inflammation treated with immunosuppressive drugs: retrospective cohort study.",
"text": "CONTEXT Whether immunosuppressive treatment adversely affects survival is unclear. \n OBJECTIVE To assess whether i... | [
{
"docid": "9767444",
"title": "Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden.",
"text": "Ovarian cancer is the most lethal of all gynecological cancers, and there is an urgent unmet need to develop new therapies. Epithelia... |
1126 | Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED) | [
{
"docid": "21009874",
"title": "Overall and cancer related mortality among patients with ocular inflammation treated with immunosuppressive drugs: retrospective cohort study.",
"text": "CONTEXT Whether immunosuppressive treatment adversely affects survival is unclear. \n OBJECTIVE To assess whether i... | [
{
"docid": "11481946",
"title": "Obesity, type 2 diabetes, and cancer: the insulin and IGF connection.",
"text": "Epidemiological studies suggest a positive association between obesity and type 2 diabetes mellitus (T2D) with the risk of cancer and cancer-related mortality. Insulin resistance, hyperinsul... |
1127 | Systemic lupus erythematosus is a risk factor for cardiovascular disease. | [
{
"docid": "27466734",
"title": "Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study",
"text": "Objectives To develop and validate updated QRISK3 prediction algorithms to estimate the 10 year risk of cardiovascular d... | [
{
"docid": "28149602",
"title": "The role of neutrophils in the pathogenesis of systemic lupus erythematosus.",
"text": "PURPOSE OF REVIEW Recent discoveries implicate neutrophils as important regulators of innate and adaptive immunity and in the development of organ damage in systemic autoimmune diseas... |
1128 | T cell receptor /CD3 microdomains are required to induce the immunologic synapse. | [
{
"docid": "33499189",
"title": "Full activation of the T cell receptor requires both clustering and conformational changes at CD3.",
"text": "T cell receptor (TCR-CD3) triggering involves both receptor clustering and conformational changes at the cytoplasmic tails of the CD3 subunits. The mechanism by ... | [
{
"docid": "6936141",
"title": "Nef is physically recruited into the immunological synapse and potentiates T cell activation early after TCR engagement.",
"text": "The HIV-1 protein Nef enhances viral pathogenicity and accelerates disease progression in vivo. Nef potentiates T cell activation by an unkn... |
1133 | TMEM27 is a marker for beta cells. | [
{
"docid": "24142891",
"title": "Tmem27: a cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation.",
"text": "The signals and molecular mechanisms that regulate the replication of terminally differentiated beta cells are unknown. Here, we report the identification an... | [
{
"docid": "27588420",
"title": "Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells.",
"text": "Human induced pluripotent stem cells (HiPSCs) appear to be highly similar to human embryonic stem cells (HESCs... |
1134 | TNFAIP3 is a glioblastoma tumor enhancer. | [
{
"docid": "33370",
"title": "Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth",
"text": "Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioblastoma stem cells (GSCs). GSCs are regulated by molecular pathways distinct from the... | [
{
"docid": "11578459",
"title": "Chromosome 7 gain and DNA hypermethylation at the HOXA10 locus are associated with expression of a stem cell related HOX-signature in glioblastoma",
"text": "BACKGROUND HOX genes are a family of developmental genes that are expressed neither in the developing forebrain n... |
1135 | TNFAIP3 is a glioblastoma tumor suppressor. | [
{
"docid": "33370",
"title": "Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth",
"text": "Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioblastoma stem cells (GSCs). GSCs are regulated by molecular pathways distinct from the... | [
{
"docid": "470625",
"title": "Identification of p18 INK4c as a tumor suppressor gene in glioblastoma multiforme.",
"text": "Genomic alterations leading to aberrant activation of cyclin/cyclin-dependent kinase (cdk) complexes drive the pathogenesis of many common human tumor types. In the case of gliobl... |
1136 | TNFAIP3 is a tumor enhancer in glioblastoma. | [
{
"docid": "33370",
"title": "Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth",
"text": "Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioblastoma stem cells (GSCs). GSCs are regulated by molecular pathways distinct from the... | [
{
"docid": "11578459",
"title": "Chromosome 7 gain and DNA hypermethylation at the HOXA10 locus are associated with expression of a stem cell related HOX-signature in glioblastoma",
"text": "BACKGROUND HOX genes are a family of developmental genes that are expressed neither in the developing forebrain n... |
1138 | TRAP+ osteoclasts regulate mature osteoblast maintenance. | [
{
"docid": "6796297",
"title": "PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis",
"text": "Osteogenesis during bone modeling and remodeling is coupled with angiogenesis. A recent study showed that a specific vessel subtype, strongly positive for CD31 and endomuc... | [
{
"docid": "3531388",
"title": "CD200R/CD200 Inhibits Osteoclastogenesis: New Mechanism of Osteoclast Control by Mesenchymal Stem Cells in Human",
"text": "Bone homeostasis is maintained by the balance between bone-forming osteoblasts and bone-degrading osteoclasts. Osteoblasts have a mesenchymal origin... |
1139 | Taking 400mg of α-tocopheryl acetate does not prevent prostate cancer. | [
{
"docid": "12009265",
"title": "Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial.",
"text": "CONTEXT Many individuals take vitamins in the hopes of preventing chronic diseases such as cancer, and vitamins E and C are amo... | [
{
"docid": "25513319",
"title": "Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis.",
"text": "Metabolic pathway reprogramming is a hallmark of cancer cell growth and survival and supports the anabolic and energetic demands of these rapidly dividing cel... |
1141 | Taking 400mg of α-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer. | [
{
"docid": "12009265",
"title": "Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial.",
"text": "CONTEXT Many individuals take vitamins in the hopes of preventing chronic diseases such as cancer, and vitamins E and C are amo... | [
{
"docid": "30720103",
"title": "Vitamin D status: measurement, interpretation, and clinical application.",
"text": "Vitamin D, the sunshine vitamin, is now recognized not only for its importance in promoting bone health in children and adults but also for other health benefits, including reducing the r... |
1142 | Taking anti-depresents is associated with a decrease in the Aβ level in the brain of experimental animals. | [
{
"docid": "5260382",
"title": "An Antidepressant Decreases CSF Aβ Production in Healthy Individuals and in Transgenic AD Mice",
"text": "Serotonin signaling suppresses generation of amyloid-β (Aβ) in vitro and in animal models of Alzheimer’s disease (AD). We show that in an aged transgenic AD mouse mod... | [
{
"docid": "15347087",
"title": "Amyloid accumulation is a late event in sporadic Alzheimer's disease-like pathology in nontransgenic rats",
"text": "The amyloid cascade hypothesis posits that deposition of the amyloid β (Aβ) peptide in the brain is a key event in the initiation of Alzheimer's disease (... |
1145 | Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India. | [
{
"docid": "10071552",
"title": "Averting Obesity and Type 2 Diabetes in India through Sugar-Sweetened Beverage Taxation: An Economic-Epidemiologic Modeling Study",
"text": "BACKGROUND Taxing sugar-sweetened beverages (SSBs) has been proposed in high-income countries to reduce obesity and type 2 diabete... | [
{
"docid": "9822397",
"title": "Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women.",
"text": "CONTEXT Sugar-sweetened beverages like soft drinks and fruit punches contain large amounts of readily absorbable sugars and may contribute to weight gain an... |
1148 | Ten percent (10%) of kidney cancers in the UK are attributable to excess weight. | [
{
"docid": "4828631",
"title": "Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5·24 million UK adults",
"text": "BACKGROUND High body-mass index (BMI) predisposes to several site-specific cancers, but a large-scale systematic and detailed characterisation of patterns... | [
{
"docid": "18340282",
"title": "Gene–environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study",
"text": "BACKGROUND Information is scarce about the combined effects on breast cancer incidence of low-penetrance genetic susceptibility polymorphisms and ... |
1153 | The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces. | [
{
"docid": "7370282",
"title": "Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2",
"text": "To initiate adaptive immunity, dendritic cells (DCs) move from parenchymal tissues to lymphoid organs by migrating along stromal scaffolds that d... | [
{
"docid": "8596357",
"title": "Porcine circovirus type 2 DNA influences cytoskeleton rearrangements in plasmacytoid and monocyte-derived dendritic cells.",
"text": "Functional disruption of dendritic cells (DC) is an important strategy for viral pathogens to evade host defences. In this context, porcin... |
1156 | The DESMOND program caused substantial weight loss in most participants. | [
{
"docid": "12584053",
"title": "Effectiveness of a diabetes education and self management programme (DESMOND) for people with newly diagnosed type 2 diabetes mellitus: three year follow-up of a cluster randomised controlled trial in primary care",
"text": "OBJECTIVE To measure whether the benefits of a... | [
{
"docid": "7098463",
"title": "Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial.",
"text": "CONTEXT Observational studies suggest that surgically induced loss of weight may be effective therapy for type 2 diabetes. \n OBJECTIVE To determine if sur... |
1157 | The DESMOND program demonstrates no significant impact on biochemical outcomes. | [
{
"docid": "12584053",
"title": "Effectiveness of a diabetes education and self management programme (DESMOND) for people with newly diagnosed type 2 diabetes mellitus: three year follow-up of a cluster randomised controlled trial in primary care",
"text": "OBJECTIVE To measure whether the benefits of a... | [
{
"docid": "40127292",
"title": "Apoptosis and chemoresistance in transgenic cancer models",
"text": "Multidrug resistance remains an unresolved problem in clinical oncology. Over a decade ago genes encoding cellular efflux pumps were shown to confer resistance to a broad spectrum of biochemically unrel... |
1158 | The DESMOND program demonstrates no significant impact on lifestyles outcomes. | [
{
"docid": "12584053",
"title": "Effectiveness of a diabetes education and self management programme (DESMOND) for people with newly diagnosed type 2 diabetes mellitus: three year follow-up of a cluster randomised controlled trial in primary care",
"text": "OBJECTIVE To measure whether the benefits of a... | [
{
"docid": "2787558",
"title": "The effect of cigarette smoking, alcohol consumption and fruit and vegetable consumption on IVF outcomes: a review and presentation of original data",
"text": "BACKGROUND Lifestyle factors including cigarette smoking, alcohol consumption and nutritional habits impact on h... |
1159 | The DESMOND program demonstrates no significant impact on weight loss. | [
{
"docid": "12584053",
"title": "Effectiveness of a diabetes education and self management programme (DESMOND) for people with newly diagnosed type 2 diabetes mellitus: three year follow-up of a cluster randomised controlled trial in primary care",
"text": "OBJECTIVE To measure whether the benefits of a... | [
{
"docid": "43220289",
"title": "Psychological Outcome 4 Years after Restrictive Bariatric Surgery",
"text": "Extreme obesity is associated with severe psychiatric and somatic comorbidity and impairment of psychosocial functioning. Bariatric surgery is the most effective treatment not only with regard t... |
1161 | The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line. | [
{
"docid": "13048272",
"title": "Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators.",
"text": "Combinatorial transcription factor (TF) interactions control cellular phenotypes and, therefore, underpin stem cell formation, m... | [
{
"docid": "11902109",
"title": "Direct sensing of systemic and nutritional signals by hematopoietic progenitors in Drosophila",
"text": "The Drosophila lymph gland is a haematopoietic organ in which progenitor cells, which are most akin to the common myeloid progenitor in mammals, proliferate and diffe... |
1162 | The DdrB protein from Deinococcus radiodurans functions as a pentamer. | [
{
"docid": "15305881",
"title": "The structure of DdrB from Deinococcus: a new fold for single-stranded DNA binding proteins",
"text": "Deinococcus spp. are renowned for their amazing ability to recover rapidly from severe genomic fragmentation as a result of exposure to extreme levels of ionizing radia... | [
{
"docid": "29877890",
"title": "Histone chaperones and nucleosome assembly.",
"text": "Recent structures of the nucleosome core particle reveal details of histone-histone and histone-DNA interactions. These structures have now set the stage for understanding chromatin assembly and dynamics during repli... |
1164 | The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone. | [
{
"docid": "4455466",
"title": "ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression",
"text": "Recognition of modified histones by ‘reader’ proteins plays a critical role in the regulation of chromatin. H3K36 trimethylation (H3K36me3) is deposited onto the nucleosomes in ... | [
{
"docid": "4312169",
"title": "Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma",
"text": "Glioblastoma multiforme (GBM) is a lethal brain tumour in adults and children. However, DNA copy number and gene expression signatures indicate differences between adult... |
1165 | The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone. | [
{
"docid": "4455466",
"title": "ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression",
"text": "Recognition of modified histones by ‘reader’ proteins plays a critical role in the regulation of chromatin. H3K36 trimethylation (H3K36me3) is deposited onto the nucleosomes in ... | [
{
"docid": "4312169",
"title": "Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma",
"text": "Glioblastoma multiforme (GBM) is a lethal brain tumour in adults and children. However, DNA copy number and gene expression signatures indicate differences between adult... |
1166 | The H2A-H2B eviction defect is compensated for by other histone chaperone(s). | [
{
"docid": "9889151",
"title": "FACT Disrupts Nucleosome Structure by Binding H2A-H2B with Conserved Peptide Motifs.",
"text": "FACT, a heterodimer of Spt16 and Pob3, is an essential histone chaperone. We show that the H2A-H2B binding activity that is central to FACT function resides in short acidic reg... | [
{
"docid": "9451052",
"title": "Stepwise Histone Replacement by SWR1 Requires Dual Activation with Histone H2A.Z and Canonical Nucleosome",
"text": "Histone variant H2A.Z-containing nucleosomes are incorporated at most eukaryotic promoters. This incorporation is mediated by the conserved SWR1 complex, w... |
1168 | The HSV-2 infection is typically asymptomatic. | [
{
"docid": "8563659",
"title": "Persistence of HIV-1 Receptor-Positive Cells after HSV-2 Reactivation: A Potential Mechanism for Increased HIV-1 Acquisition",
"text": "To explore the mechanism by which herpes simplex virus (HSV)-2 infection is related to HIV-1 acquisition, we conducted in situ analysis ... | [
{
"docid": "40584205",
"title": "Biological properties of herpes simplex virus 2 replication-defective mutant strains in a murine nasal infection model.",
"text": "We used a mouse nasal model of herpes simplex virus 2 (HSV-2) infection to examine the biological properties of HSV-2 wild-type (wt), TK-neg... |
1169 | The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity. | [
{
"docid": "4319174",
"title": "Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis",
"text": "All homeotherms use thermogenesis to maintain their core body temperature, ensuring that cellular functions and physiological processes can continue in cold environment... | [
{
"docid": "14865329",
"title": "Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders",
"text": "Brown fat is a specialized fat depot that can increase energy expenditure and produce heat. After the recent discovery of the presence of active brown fat in human adults and n... |
1170 | The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death. | [
{
"docid": "18956141",
"title": "NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions",
"text": "Intestinal epithelial cells (IECs) regulate gut immune homeostasis, and impaired epithelial responses are implicated in ... | [
{
"docid": "23078022",
"title": "MUC1 oncoprotein activates the IκB kinase β complex and constitutive NF-κB signalling",
"text": "Nuclear factor-κB (NF-κB) is constitutively activated in diverse human malignancies by mechanisms that are not understood. The MUC1 oncoprotein is aberrantly overexpressed by... |
1171 | The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death. | [
{
"docid": "18956141",
"title": "NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions",
"text": "Intestinal epithelial cells (IECs) regulate gut immune homeostasis, and impaired epithelial responses are implicated in ... | [
{
"docid": "23078022",
"title": "MUC1 oncoprotein activates the IκB kinase β complex and constitutive NF-κB signalling",
"text": "Nuclear factor-κB (NF-κB) is constitutively activated in diverse human malignancies by mechanisms that are not understood. The MUC1 oncoprotein is aberrantly overexpressed by... |
1173 | The PDPN gene deactivates the C-type lectin receptor (CLEC-2). | [
{
"docid": "7370282",
"title": "Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2",
"text": "To initiate adaptive immunity, dendritic cells (DCs) move from parenchymal tissues to lymphoid organs by migrating along stromal scaffolds that d... | [
{
"docid": "8563659",
"title": "Persistence of HIV-1 Receptor-Positive Cells after HSV-2 Reactivation: A Potential Mechanism for Increased HIV-1 Acquisition",
"text": "To explore the mechanism by which herpes simplex virus (HSV)-2 infection is related to HIV-1 acquisition, we conducted in situ analysis ... |
1174 | The PPR MDA5 has twenty N-terminal CARD domains. | [
{
"docid": "31272411",
"title": "Immune signaling by RIG-I-like receptors.",
"text": "The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 play a major role in pathogen sensing of RNA virus infection to initiate and modulate antiviral immunity. The RLRs detect viral RNA ligands or processed self RNA in... | [
{
"docid": "15419873",
"title": "Cytosolic viral sensor RIG-I is a 5'-triphosphate-dependent translocase on double-stranded RNA.",
"text": "Retinoic acid inducible-gene I (RIG-I) is a cytosolic multidomain protein that detects viral RNA and elicits an antiviral immune response. Two N-terminal caspase ac... |
1176 | The PRDM1 gene is a key determinant of primordial germ cells. | [
{
"docid": "13910150",
"title": "The Germ Cell Determinant Blimp1 Is Not Required for Derivation of Pluripotent Stem Cells",
"text": "Blimp1 (Prdm1), the key determinant of primordial germ cells (PGCs), plays a combinatorial role with Prdm14 during PGC specification from postimplantation epiblast cells.... | [
{
"docid": "13955536",
"title": "The Dynamics of Genome-wide DNA Methylation Reprogramming in Mouse Primordial Germ Cells",
"text": "Genome-wide DNA methylation reprogramming occurs in mouse primordial germ cells (PGCs) and preimplantation embryos, but the precise dynamics and biological outcomes are la... |
1177 | The PRDM1 gene, when combined with the PRDM14 gene, plays an important role during primordial germ cell specification. | [
{
"docid": "13910150",
"title": "The Germ Cell Determinant Blimp1 Is Not Required for Derivation of Pluripotent Stem Cells",
"text": "Blimp1 (Prdm1), the key determinant of primordial germ cells (PGCs), plays a combinatorial role with Prdm14 during PGC specification from postimplantation epiblast cells.... | [
{
"docid": "13955536",
"title": "The Dynamics of Genome-wide DNA Methylation Reprogramming in Mouse Primordial Germ Cells",
"text": "Genome-wide DNA methylation reprogramming occurs in mouse primordial germ cells (PGCs) and preimplantation embryos, but the precise dynamics and biological outcomes are la... |
1178 | The PRR MDA5 has a C-terminal domain. | [
{
"docid": "31272411",
"title": "Immune signaling by RIG-I-like receptors.",
"text": "The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 play a major role in pathogen sensing of RNA virus infection to initiate and modulate antiviral immunity. The RLRs detect viral RNA ligands or processed self RNA in... | [
{
"docid": "6144337",
"title": "AgDscam, a Hypervariable Immunoglobulin Domain-Containing Receptor of the Anopheles gambiae Innate Immune System ",
"text": "Activation of the insect innate immune system is dependent on a limited number of pattern recognition receptors (PRRs) capable of interac... |
1181 | The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs). | [
{
"docid": "301838",
"title": "Rank Signaling Links the Development of Invariant γδ T Cell Progenitors and Aire+ Medullary Epithelium",
"text": "The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing m... | [
{
"docid": "10162553",
"title": "Ablation and regeneration of tolerance-inducing medullary thymic epithelial cells after cyclosporine, cyclophosphamide, and dexamethasone treatment.",
"text": "Immunosuppressive drugs and cytotoxic chemotherapy agents are designed to kill or suppress autoreactive, alloag... |
1182 | The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae). | [
{
"docid": "14541844",
"title": "Reconstruction of the yeast Snf1 kinase regulatory network reveals its role as a global energy regulator",
"text": "Highly conserved among eukaryotic cells, the AMP-activated kinase (AMPK) is a central regulator of carbon metabolism. To map the complete network of intera... | [
{
"docid": "13613916",
"title": "Glucose repression in Saccharomyces cerevisiae",
"text": "Glucose is the primary source of energy for the budding yeast Saccharomyces cerevisiae. Although yeast cells can utilize a wide range of carbon sources, presence of glucose suppresses molecular activities involved... |
1183 | The TRaF1/C5 rs10818488 allele polymorphism regulates the neighboring C5 gene. | [
{
"docid": "1967017",
"title": "A Candidate Gene Approach Identifies the TRAF1/C5 Region as a Risk Factor for Rheumatoid Arthritis",
"text": "Correction for: Kurreeman FAS, Padyukov L, Marques RB, Schrodi SJ, Seddighzadeh M, et al. (2007) A Candidate Gene Approach Identifies the TRAF1/C5 Region as a ... | [
{
"docid": "36242796",
"title": "Coordinate regulation of the IL-4, IL-13, and IL-5 cytokine cluster in Th2 clones revealed by allelic expression patterns.",
"text": "The cytokines IL-4, IL-13, and IL-5 are markers for the Th2 subset of effector T cells and are often expressed together. These cytokine g... |
1184 | The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program. | [
{
"docid": "16737210",
"title": "Kidney paired donation and optimizing the use of live donor organs.",
"text": "CONTEXT Blood type and crossmatch incompatibility will exclude at least one third of patients in need from receiving a live donor kidney transplant. Kidney paired donation (KPD) offers incompa... | [
{
"docid": "21859699",
"title": "Successful three-way kidney paired donation with cross-country live donor allograft transport.",
"text": "Providing transplantation opportunities for patients with incompatible live donors through kidney paired donation (KPD) is seen as one of the important strategies fo... |
1186 | The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks. | [
{
"docid": "7485455",
"title": "Using Routine Surveillance Data to Estimate the Epidemic Potential of Emerging Zoonoses: Application to the Emergence of US Swine Origin Influenza A H3N2v Virus",
"text": "BACKGROUND Prior to emergence in human populations, zoonoses such as SARS cause occasional infection... | [
{
"docid": "2338488",
"title": "The World Health Organization Adult ADHD Self-Report Scale (ASRS): a short screening scale for use in the general population.",
"text": "BACKGROUND A self-report screening scale of adult attention-deficit/hyperactivity disorder (ADHD), the World Health Organization (WHO) ... |
1188 | The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells. | [
{
"docid": "4394817",
"title": "E2F1-3 Switch from Activators in Progenitor Cells to Repressors in Differentiating Cells",
"text": "In the established model of mammalian cell cycle control, the retinoblastoma protein (Rb) functions to restrict cells from entering S phase by binding and sequestering E2f ... | [
{
"docid": "41710132",
"title": "Regulation of E2Fs and senescence by PML nuclear bodies.",
"text": "The tumor suppressor PML (promyelocytic leukemia protein) regulates cellular senescence and terminal differentiation, two processes that implicate a permanent exit from the cell cycle. Here, we show that... |
1190 | The amount of publicly available DNA data doubles every 10 months. | [
{
"docid": "30655442",
"title": "The EMBL nucleotide sequence database.",
"text": "The EMBL Nucleotide Sequence Database (http://www.ebi.ac.uk/embl. html ) constitutes Europe's primary nucleotide sequence resource. DNA and RNA sequences are directly submitted from researchers and genome sequencing group... | [
{
"docid": "32421068",
"title": "Availability of evidence of benefits on overall survival and quality of life of cancer drugs approved by European Medicines Agency: retrospective cohort study of drug approvals 2009-13",
"text": "Objective To determine the availability of data on overall survival and qua... |
1193 | The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat. | [
{
"docid": "20532591",
"title": "Tracking adipogenesis during white adipose tissue development, expansion and regeneration",
"text": "White adipose tissue displays high plasticity. We developed a system for the inducible, permanent labeling of mature adipocytes that we called the AdipoChaser mouse. We m... | [
{
"docid": "52865789",
"title": "Deficiency of Interleukin-15 Confers Resistance to Obesity by Diminishing Inflammation and Enhancing the Thermogenic Function of Adipose Tissues",
"text": "OBJECTIVE IL-15 is an inflammatory cytokine secreted by many cell types. IL-15 is also produced during physical exe... |
1195 | The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily. | [
{
"docid": "26283293",
"title": "Structural and mechanistic insights into phospholipid transfer by Ups1–Mdm35 in mitochondria",
"text": "Eukaryotic cells are compartmentalized into membrane-bounded organelles whose functions rely on lipid trafficking to achieve membrane-specific compositions of lipids. ... | [
{
"docid": "23938319",
"title": "Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies.",
"text": "Retinoid receptors (RARs and RXRs) are ligand-activated trans... |
1205 | The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions. | [
{
"docid": "5558754",
"title": "Use of serum C reactive protein and procalcitonin concentrations in addition to symptoms and signs to predict pneumonia in patients presenting to primary care with acute cough: diagnostic study",
"text": "OBJECTIVES To quantify the diagnostic accuracy of selected inflamma... | [
{
"docid": "33835579",
"title": "Pathology of postprimary tuberculosis in humans and mice: contradiction of long-held beliefs.",
"text": "Tuberculosis remains one of the world's leading infectious causes of death. Approximately 80% of all disease is due to postprimary (secondary) tuberculosis in the lun... |
1206 | The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation. | [
{
"docid": "18909530",
"title": "Contractile forces sustain and polarize hematopoiesis from stem and progenitor cells.",
"text": "Self-renewal and differentiation of stem cells depend on asymmetric division and polarized motility processes that in other cell types are modulated by nonmuscle myosin-II (M... | [
{
"docid": "27061085",
"title": "Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation.",
"text": "High-throughput mRNA sequencing (RNA-Seq) promises simultaneous transcript discovery and abundance estimation. However, this wo... |
1208 | The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium. | [
{
"docid": "10284593",
"title": "Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation",
"text": "Observational clinical and ex vivo studies have established a strong association between atrial fibrillation and inflammation. However, whether inflammation is the cause or the consequence o... | [
{
"docid": "2291922",
"title": "The surgical anatomy of the conduction tissues.",
"text": "On the basis of our collective experience we have reviewed the disposition of the cardiac conduction tissues as they might be observed by the surgeon in both normal and abnormal hearts. The sinus node lies subepic... |
1209 | The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations. | [
{
"docid": "4347374",
"title": "Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts",
"text": "Viral replication usually requires that innate intracellular lines of defence be overcome, a task usually accomplished by specialized viral gene products. The v... | [
{
"docid": "2638387",
"title": "The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA",
"text": "High mutation frequency during reverse transcription has a principal role in the genetic variation of primate lentiviral populations. It is the main driving force for the generati... |
1210 | The density of cytokine receptor bearing cells affects the distance over which cytokines act. | [
{
"docid": "4928282",
"title": "A Tunable Diffusion‐Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell‐to‐Cell Communication in the Immune System",
"text": "&NA; Immune cells communicate by exchanging cytokines to achieve a context‐appropriate response, but the distances over which... | [
{
"docid": "13636631",
"title": "Cytokine control of memory T-cell development and survival",
"text": "Evidence has accumulated that cytokines have a fundamental role in the differentiation of memory T cells. Here, we follow the CD8+ T cell from initial activation to memory-cell generation, indicating t... |
1211 | The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act. | [
{
"docid": "4928282",
"title": "A Tunable Diffusion‐Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell‐to‐Cell Communication in the Immune System",
"text": "&NA; Immune cells communicate by exchanging cytokines to achieve a context‐appropriate response, but the distances over which... | [
{
"docid": "13636631",
"title": "Cytokine control of memory T-cell development and survival",
"text": "Evidence has accumulated that cytokines have a fundamental role in the differentiation of memory T cells. Here, we follow the CD8+ T cell from initial activation to memory-cell generation, indicating t... |
1212 | The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions. | [
{
"docid": "6493422",
"title": "The myeloid transcription factor KLF2 regulates the host response to polymicrobial infection and endotoxic shock.",
"text": "Precise control of myeloid cell activation is required for optimal host defense. However, this activation process must be under exquisite control t... | [
{
"docid": "17934603",
"title": "CCR2 and CXCR4 regulate peripheral blood monocyte pharmacodynamics and link to efficacy in experimental autoimmune encephalomyelitis",
"text": "BACKGROUND CCR2 plays a key role in regulating monocyte trafficking to sites of inflammation and therefore has been the focus o... |
1214 | The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes. | [
{
"docid": "6493422",
"title": "The myeloid transcription factor KLF2 regulates the host response to polymicrobial infection and endotoxic shock.",
"text": "Precise control of myeloid cell activation is required for optimal host defense. However, this activation process must be under exquisite control t... | [
{
"docid": "13905670",
"title": "Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway",
"text": "The clinical course and eventual outcome, or prognosis, of complex diseases varies enormously between affected individuals. This variability critically de... |
1215 | The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels. | [
{
"docid": "16355392",
"title": "Modification of kidney barrier function by the urokinase receptor",
"text": "Podocyte dysfunction, represented by foot process effacement and proteinuria, is often the starting point for progressive kidney disease. Therapies aimed at the cellular level of the disease are... | [
{
"docid": "27545868",
"title": "Histone acetyltransferase PCAF regulates inflammatory molecules in the development of renal injury.",
"text": "Kidney diseases, including chronic kidney disease (CKD) and acute kidney injury (AKI), are associated with inflammation. The mechanism that regulates inflammati... |
1218 | The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1. | [
{
"docid": "15635366",
"title": "The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development.",
"text": "L3mbtl2 has been implicated in transcriptional repression and chromatin compaction but its biological function has n... | [
{
"docid": "3829232",
"title": "Structural Studies of a Four-MBT Repeat Protein MBTD1",
"text": "BACKGROUND The Polycomb group (PcG) of proteins is a family of important developmental regulators. The respective members function as large protein complexes involved in establishment and maintenance of tran... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.