query_id stringlengths 1 4 | query stringlengths 26 249 | positive_passages listlengths 1 5 | negative_passages listlengths 16 20 |
|---|---|---|---|
1219 | The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling. | [
{
"docid": "9393969",
"title": "DAF-16/FOXO employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity",
"text": "Organisms are constantly challenged by stresses and privations and require adaptive responses for their survival. The forkhead box O (FOXO) transcription factor DAF-... | [
{
"docid": "1576955",
"title": "An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans.",
"text": "Mutations in daf-2 and age-1 cause a dramatic increase in longevity as well as developmental arrest at the dauer diapause stage in Caenorhabditis elegans. daf-2... |
1220 | The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells. | [
{
"docid": "13023410",
"title": "BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks.",
"text": "The oncogenic BCR/ABL tyrosine kinase induces constitutive DNA damage in Philadelphia chromosome (Ph)-positive leukemia cells. We find that B... | [
{
"docid": "5765455",
"title": "Reactive oxygen species, DNA damage, and error-prone repair: a model for genomic instability with progression in myeloid leukemia?",
"text": "Myelodysplastic syndromes (MDS) comprise a heterogeneous group of disorders characterized by ineffective hematopoiesis, with an in... |
1223 | The innate immune response struggles to remove small numbers of parasites. | [
{
"docid": "5289038",
"title": "Partitioning regulatory mechanisms of within-host malaria dynamics using the effective propagation number.",
"text": "Immune clearance and resource limitation (via red blood cell depletion) shape the peaks and troughs of malaria parasitemia, which in turn affect disease s... | [
{
"docid": "6144337",
"title": "AgDscam, a Hypervariable Immunoglobulin Domain-Containing Receptor of the Anopheles gambiae Innate Immune System ",
"text": "Activation of the insect innate immune system is dependent on a limited number of pattern recognition receptors (PRRs) capable of interac... |
1224 | The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression. | [
{
"docid": "21932050",
"title": "Microarrays for the study of viral gene expression during human cytomegalovirus latent infection.",
"text": "Human cytomegalovirus (HCMV) is one of the largest known DNA viruses. It is ubiquitous, and following resolution of primary productive infection, it persists in t... | [
{
"docid": "26873988",
"title": "Viral interleukin-10 expressed by human cytomegalovirus during the latent phase of infection modulates latently infected myeloid cell differentiation.",
"text": "The human cytomegalovirus UL111A gene is expressed during latent and productive infections, and it codes for ... |
1227 | The mean suicide rate in women is higher after miscarriage than live birth. | [
{
"docid": "25641414",
"title": "Suicides after pregnancy in Finland, 1987-94: register linkage study.",
"text": "OBJECTIVE To determine rates of suicide associated with pregnancy by the type of pregnancy. \n DESIGN Register linkage study. Information on suicides in women of reproductive age was linke... | [
{
"docid": "7662395",
"title": "Perinatal mortality in rural China: retrospective cohort study.",
"text": "OBJECTIVES To explore the use of local civil registration data to assess the perinatal mortality in a typical rural county in a less developed province in China, 1999-2000. \n DESIGN Retrospectiv... |
1228 | The mean suicide rate in women is lower after miscarriage than live birth. | [
{
"docid": "25641414",
"title": "Suicides after pregnancy in Finland, 1987-94: register linkage study.",
"text": "OBJECTIVE To determine rates of suicide associated with pregnancy by the type of pregnancy. \n DESIGN Register linkage study. Information on suicides in women of reproductive age was linke... | [
{
"docid": "7662395",
"title": "Perinatal mortality in rural China: retrospective cohort study.",
"text": "OBJECTIVES To explore the use of local civil registration data to assess the perinatal mortality in a typical rural county in a less developed province in China, 1999-2000. \n DESIGN Retrospectiv... |
1229 | The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites. | [
{
"docid": "1676568",
"title": "CLASPs link focal adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover",
"text": "Turnover of integrin-based focal adhesions (FAs) with the extracellular matrix (ECM) is essential for coordinated cell movement. In collectively migrati... | [
{
"docid": "20943272",
"title": "ADAM13 disintegrin and cysteine-rich domains bind to the second heparin-binding domain of fibronectin.",
"text": "ADAM13 is a member of the disintegrin and metalloprotease protein family that is expressed on cranial neural crest cells surface and is essential for their m... |
1230 | The minor G allele of FOXO3 downregulates pro-inflammatory cytokines. | [
{
"docid": "13905670",
"title": "Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway",
"text": "The clinical course and eventual outcome, or prognosis, of complex diseases varies enormously between affected individuals. This variability critically de... | [
{
"docid": "6144969",
"title": "Enterovirus-induced gene expression profile is critical for human pancreatic islet destruction",
"text": "Virally induced inflammatory responses, beta cell destruction and release of beta cell autoantigens may lead to autoimmune reactions culminating in type 1 diabetes. T... |
1231 | The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease. | [
{
"docid": "13905670",
"title": "Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway",
"text": "The clinical course and eventual outcome, or prognosis, of complex diseases varies enormously between affected individuals. This variability critically de... | [
{
"docid": "24906548",
"title": "Apolipoprotein E4 as a predictor of outcomes in pediatric mild traumatic brain injury.",
"text": "The epsilon4 allele of the apolipoprotein E (APOE) gene has been linked to negative outcomes among adults with traumatic brain injury (TBI) across the spectrum of severity, ... |
1234 | The minor G allele of FOXO3 up-regulates IL-10. | [
{
"docid": "13905670",
"title": "Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway",
"text": "The clinical course and eventual outcome, or prognosis, of complex diseases varies enormously between affected individuals. This variability critically de... | [
{
"docid": "12443371",
"title": "Apolipoprotein E genotype and concussion in college athletes.",
"text": "OBJECTIVE To evaluate the association between apolipoprotein E (APOE) polymorphisms (E2, C/T Arg158Cys; E4, T/C Cys112Arg; and promoter, g-219t) and the history of concussion in college athletes. We... |
1235 | The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue. | [
{
"docid": "17973161",
"title": "Human ‘brite / beige’ adipocytes develop from capillary networks and their implantation improves metabolic homeostasis in mice",
"text": "Uncoupling protein 1 (UCP1) is highly expressed in brown adipose tissue, where it generates heat by uncoupling electron transport fro... | [
{
"docid": "14865329",
"title": "Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders",
"text": "Brown fat is a specialized fat depot that can increase energy expenditure and produce heat. After the recent discovery of the presence of active brown fat in human adults and n... |
1236 | The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue. | [
{
"docid": "17973161",
"title": "Human ‘brite / beige’ adipocytes develop from capillary networks and their implantation improves metabolic homeostasis in mice",
"text": "Uncoupling protein 1 (UCP1) is highly expressed in brown adipose tissue, where it generates heat by uncoupling electron transport fro... | [
{
"docid": "14865329",
"title": "Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders",
"text": "Brown fat is a specialized fat depot that can increase energy expenditure and produce heat. After the recent discovery of the presence of active brown fat in human adults and n... |
1237 | The most prevalent adverse events to Semaglutide are cardiovascular. | [
{
"docid": "3654468",
"title": "Effect of Oral Semaglutide Compared With Placebo and Subcutaneous Semaglutide on Glycemic Control in Patients With Type 2 Diabetes: A Randomized Clinical Trial",
"text": "Importance Glucagon-like peptide-1 (GLP-1) receptor agonists are effective therapies for the treatmen... | [
{
"docid": "46277811",
"title": "LPA Gene, Ethnicity, and Cardiovascular Events",
"text": "Background: The relationship of LPA single nucleotide polymorphisms (SNPs), apolipoprotein(a) isoforms, and lipoprotein(a) [Lp(a)] levels with major adverse cardiovascular events (MACE) in different ethnic groups ... |
1238 | The most prevalent adverse events to Semaglutide are gastrointestinal. | [
{
"docid": "3654468",
"title": "Effect of Oral Semaglutide Compared With Placebo and Subcutaneous Semaglutide on Glycemic Control in Patients With Type 2 Diabetes: A Randomized Clinical Trial",
"text": "Importance Glucagon-like peptide-1 (GLP-1) receptor agonists are effective therapies for the treatmen... | [
{
"docid": "37628989",
"title": "The safety of intravenous fluorescein for confocal laser endomicroscopy in the gastrointestinal tract.",
"text": "BACKGROUND Confocal laser endomicroscopy (CLE) is rapidly emerging as a valuable tool for gastrointestinal endoscopic imaging. Fluorescent contrast agents ar... |
1239 | The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin. | [
{
"docid": "21387297",
"title": "Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming.",
"text": "Cardiovascular disease is a leading cause of death worldwide. The limited capability of heart tissue to regenerate has prompted methodological developme... | [
{
"docid": "6148876",
"title": "Islet1 derivatives in the heart are of both neural crest and second heart field origin.",
"text": "RATIONALE Islet1 (Isl1) has been proposed as a marker of cardiac progenitor cells derived from the second heart field and is utilized to identify and purify cardiac progenit... |
1244 | The number of unfertilized oocytes in mated hermaphrodites increases with age. | [
{
"docid": "18949516",
"title": "TGF-β and Insulin Signaling Regulate Reproductive Aging via Oocyte and Germline Quality Maintenance",
"text": "Reproductive cessation is perhaps the earliest aging phenotype that humans experience. Similarly, reproduction of Caenorhabditis elegans ceases in mid-adulthood... | [
{
"docid": "36178047",
"title": "Decrease of learning capacity in offspring with increasing paternal age in the rat.",
"text": "The same 15 male Wistar rats at the ages of 2.5, 6, 10, 14, 18, and 22 months were successively randomly mated with 2.5-month-old females. In a separate experiment, 15 male Wis... |
1246 | The one-child policy has created a hospitable environment for female infants. | [
{
"docid": "7662395",
"title": "Perinatal mortality in rural China: retrospective cohort study.",
"text": "OBJECTIVES To explore the use of local civil registration data to assess the perinatal mortality in a typical rural county in a less developed province in China, 1999-2000. \n DESIGN Retrospectiv... | [
{
"docid": "70455704",
"title": "Weight gain during pregnancy: reexamining the guidelines.",
"text": "As women of childbearing age have become heavier, the trade-off between maternal and child health created by variation in gestational weight gain has become more difficult to reconcile. Weight Gain Duri... |
1247 | The origin of the CRF01_1b2k protein occurred between 1923 and 1956. | [
{
"docid": "5114282",
"title": "The Global Spread of Hepatitis C Virus 1a and 1b: A Phylodynamic and Phylogeographic Analysis",
"text": "BACKGROUND Hepatitis C virus (HCV) is estimated to affect 130-180 million people worldwide. Although its origin is unknown, patterns of viral diversity suggest that HC... | [
{
"docid": "406733",
"title": "Histones are incorporated in trans during reassembly of the yeast PHO5 promoter.",
"text": "In yeast, remodeling of PHO5 promoter chromatin upon activation is accompanied by transient hyperacetylation and subsequent eviction of histones from the promoter in trans. In the c... |
1248 | The peak incidence of fractures occurs during pubertal growth spurt in early adolescents. | [
{
"docid": "7209559",
"title": "Incidence of childhood distal forearm fractures over 30 years: a population-based study.",
"text": "CONTEXT The incidence of distal forearm fractures in children peaks around the time of the pubertal growth spurt, possibly because physical activity increases at the time o... | [
{
"docid": "44572913",
"title": "Calcium and peak bone mass.",
"text": "On the basis of previous epidemiological, clinical and experimental studies, it was demonstrated that adequate calcium intake during growth may influence peak bone mass/density, and may be instrumental in preventing subsequent postm... |
1249 | The peak incidence of fractures occurs in toddlers. | [
{
"docid": "7209559",
"title": "Incidence of childhood distal forearm fractures over 30 years: a population-based study.",
"text": "CONTEXT The incidence of distal forearm fractures in children peaks around the time of the pubertal growth spurt, possibly because physical activity increases at the time o... | [
{
"docid": "3613041",
"title": "Therapeutic equivalence of alendronate 70 mg once-weekly and alendronate 10 mg daily in the treatment of osteoporosis. Alendronate Once-Weekly Study Group.",
"text": "Dosing convenience is a key element in the effective management of any chronic disease, and is particular... |
1253 | The predominant localization of Linc00173 is in mononuclear macrophage nuclei. | [
{
"docid": "3321943",
"title": "The non-coding RNA landscape of human hematopoiesis and leukemia",
"text": "Non-coding RNAs have emerged as crucial regulators of gene expression and cell fate decisions. However, their expression patterns and regulatory functions during normal and malignant human hematop... | [
{
"docid": "12827098",
"title": "Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes.",
"text": "Despite accumulating evidence suggesting local self-maintenance of tissue macrophages in the steady state, the dogma remains that tiss... |
1254 | The proliferative capacity of neural progenitors differs across species. | [
{
"docid": "16939583",
"title": "2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size.",
"text": "Variation in cerebral cortex size and complexity is thought to contribute to differences in cognitive ability be... | [
{
"docid": "39465575",
"title": "Direct reprogramming of fibroblasts into neural stem cells by defined factors.",
"text": "Recent studies have shown that defined sets of transcription factors can directly reprogram differentiated somatic cells to a different differentiated cell type without passing thro... |
1255 | The proliferative capacity of progenitors is regulated cell-autonomously. | [
{
"docid": "16939583",
"title": "2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size.",
"text": "Variation in cerebral cortex size and complexity is thought to contribute to differences in cognitive ability be... | [
{
"docid": "3495456",
"title": "Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions",
"text": "Summary Neutrophils are specialized innate cells that require constant replenishment from proliferative bone marrow (BM) precurso... |
1257 | The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries. | [
{
"docid": "581832",
"title": "Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015",
"text": "BACKGROUND Healthy life expectancy (HALE) and dis... | [
{
"docid": "25451374",
"title": "Cardiovascular risk and events in 17 low-, middle-, and high-income countries.",
"text": "BACKGROUND More than 80% of deaths from cardiovascular disease are estimated to occur in low-income and middle-income countries, but the reasons are unknown. \n METHODS We enrolle... |
1258 | The recruitment of Wdr5 to its target loci depends on Kat8. | [
{
"docid": "12040627",
"title": "The histone acetyltransferase MOF is a key regulator of the embryonic stem cell core transcriptional network.",
"text": "Pluripotent embryonic stem cells (ESCs) maintain self-renewal and the potential for rapid response to differentiation cues. Both ESC features are subj... | [
{
"docid": "4407318",
"title": "Replication stress activates DNA repair synthesis in mitosis",
"text": "Oncogene-induced DNA replication stress has been implicated as a driver of tumorigenesis. Many chromosomal rearrangements characteristic of human cancers originate from specific regions of the genome ... |
1260 | The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up. | [
{
"docid": "24341590",
"title": "Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen.",
"text": "CONTEXT The growth inhibitory effect of tamoxifen, which is used for the treatment of hormone receptor-positive breast cancer, is mediated ... | [
{
"docid": "13069283",
"title": "Influence of CYP2D6 Polymorphisms on Serum Levels of Tamoxifen Metabolites in Spanish Women with Breast Cancer",
"text": "BACKGROUND Estrogen receptor-positive breast cancer tumors depend on estrogen signaling for their growth and replication and can be treated by anti-e... |
1261 | The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells. | [
{
"docid": "13023410",
"title": "BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks.",
"text": "The oncogenic BCR/ABL tyrosine kinase induces constitutive DNA damage in Philadelphia chromosome (Ph)-positive leukemia cells. We find that B... | [
{
"docid": "5765455",
"title": "Reactive oxygen species, DNA damage, and error-prone repair: a model for genomic instability with progression in myeloid leukemia?",
"text": "Myelodysplastic syndromes (MDS) comprise a heterogeneous group of disorders characterized by ineffective hematopoiesis, with an in... |
1263 | The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element. | [
{
"docid": "3981729",
"title": "Structural basis for sequence-specific recognition of DNA by TAL effectors.",
"text": "TAL (transcription activator-like) effectors, secreted by phytopathogenic bacteria, recognize host DNA sequences through a central domain of tandem repeats. Each repeat comprises 33 to ... | [
{
"docid": "46816158",
"title": "The crystal structure of TAL effector PthXo1 bound to its DNA target.",
"text": "DNA recognition by TAL effectors is mediated by tandem repeats, each 33 to 35 residues in length, that specify nucleotides via unique repeat-variable diresidues (RVDs). The crystal structure... |
1265 | The risk of breast cancer among parous women decreases with placental weight of pregnancies. | [
{
"docid": "37480103",
"title": "Pregnancy characteristics and maternal risk of breast cancer.",
"text": "CONTEXT During pregnancy, serum levels of estrogen, progesterone, and other hormones are markedly higher than during other periods of life. Pregnancy hormones primarily are produced in the placenta,... | [
{
"docid": "13765757",
"title": "Timing of menarche and first full-term birth in relation to breast cancer risk.",
"text": "Ages at menarche and first birth are established risk factors for breast cancer. The interval between these ages may also affect risk, since the breast is more susceptible to carci... |
1268 | The risk of cancer rises with level of alcohol consumption. | [
{
"docid": "52072815",
"title": "Alcohol use and burden for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016",
"text": "Summary Background Alcohol use is a leading risk factor for death and disability, but its overall association with health rem... | [
{
"docid": "46437558",
"title": "The role of alcohol in the Russian mortality crisis.",
"text": "AIMS Alcohol is believed to be an important factor behind the sharp rise in mortality during the period 1990-94 in Russia. However, the rise in the standard alcohol consumption proxy does not seem to be suff... |
1269 | The risk of female prisoners harming themselves is ten times that of male prisoners. | [
{
"docid": "13900610",
"title": "Self-harm in prisons in England and Wales: an epidemiological study of prevalence, risk factors, clustering, and subsequent suicide",
"text": "BACKGROUND Self-harm and suicide are common in prisoners, yet robust information on the full extent and characteristics of peopl... | [
{
"docid": "14843502",
"title": "Self-reported health status and access to health services in a sample of prisoners in Italy",
"text": "BACKGROUND Self-reported health status in underserved population of prisoners has not been extensively explored. The purposes of this cross-sectional study were to asse... |
1275 | The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) is decorated with VgrG and PAAR proteins. | [
{
"docid": "27731651",
"title": "A view to a kill: the bacterial type VI secretion system.",
"text": "The bacterial type VI secretion system (T6SS) is an organelle that is structurally and mechanistically analogous to an intracellular membrane-attached contractile phage tail. Recent studies determined t... | [
{
"docid": "4406819",
"title": "PAAR-repeat proteins sharpen and diversify the Type VI secretion system spike",
"text": "The bacterial type VI secretion system (T6SS) is a large multicomponent, dynamic macromolecular machine that has an important role in the ecology of many Gram-negative bacteria. T6SS ... |
1276 | The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response. | [
{
"docid": "3475317",
"title": "Inflammatory signaling in human Tuberculosis granulomas is spatially organized",
"text": "Granulomas are the pathological hallmark of tuberculosis (TB). However, their function and mechanisms of formation remain poorly understood. To understand the role of granulomas in T... | [
{
"docid": "34615397",
"title": "Human tuberculous granulomas induce peripheral lymphoid follicle-like structures to orchestrate local host defence in the lung.",
"text": "The human tuberculous granuloma provides the morphological basis for local immune processes central to the outcome of tuberculosis. ... |
1284 | Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events | [
{
"docid": "3578380",
"title": "Postmarket Safety Events Among Novel Therapeutics Approved by the US Food and Drug Administration Between 2001 and 2010",
"text": "Importance Postmarket safety events of novel pharmaceuticals and biologics occur when new safety risks are identified after initial regulator... | [
{
"docid": "13256155",
"title": "Molecularly targeted therapy based on tumour molecular profiling versus conventional therapy for advanced cancer (SHIVA): a multicentre, open-label, proof-of-concept, randomised, controlled phase 2 trial.",
"text": "BACKGROUND Molecularly targeted agents have been report... |
1288 | There is a positive correlation between hip fractures and statin use. | [
{
"docid": "4687948",
"title": "HMG-CoA reductase inhibitors and the risk of hip fractures in elderly patients.",
"text": "CONTEXT Recent animal studies have found that 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) lipid-lowering drugs (statins) substantially increase bone formation, but whether stati... | [
{
"docid": "16812091",
"title": "Clinical use of bone densitometry: scientific review.",
"text": "CONTEXT Osteoporosis causes substantial morbidity and costs $13.8 billion annually in the United States. Measurement of bone mass by densitometry is a primary part of diagnosing osteoporosis and deciding a ... |
1289 | There is a relation between Erythromycin use and hypertrophic pyloric stenosis. | [
{
"docid": "21239672",
"title": "Use of macrolides in mother and child and risk of infantile hypertrophic pyloric stenosis: nationwide cohort study",
"text": "OBJECTIVE To assess the association between use of macrolide antibiotics in mothers and infants from pregnancy onset until 120 days after birth a... | [
{
"docid": "27550580",
"title": "T1 mapping for myocardial extracellular volume measurement by CMR: bolus only versus primed infusion technique.",
"text": "OBJECTIVES The aim of this study was to determine the accuracy of the contrast \"bolus only\" T1 mapping cardiac magnetic resonance (CMR) technique ... |
1291 | There is no association between HNF4A mutations and diabetes risks. | [
{
"docid": "56893404",
"title": "Macrosomia and Hyperinsulinaemic Hypoglycaemia in Patients with Heterozygous Mutations in the HNF4A Gene",
"text": "Background Macrosomia is associated with considerable neonatal and maternal morbidity. Factors that predict macrosomia are poorly understood. The increase... | [
{
"docid": "4886637",
"title": "Diabetes, metabolic syndrome, and breast cancer: a review of the current evidence.",
"text": "Incidences of breast cancer, type 2 diabetes, and metabolic syndrome have increased over the past decades with the obesity epidemic, especially in industrialized countries. Insul... |
1293 | There is no increased risk of hypospadias with clomiphene. | [
{
"docid": "43329366",
"title": "Use of clomifene during early pregnancy and risk of hypospadias: population based case-control study.",
"text": "Clomifene is widely used for inducing ovulation.1 It is structurally related to diethylstilbestrol, which has been linked to vaginal and cervical clear cell a... | [
{
"docid": "380526",
"title": "Common variants in DGKK are strongly associated with risk of hypospadias",
"text": "Hypospadias is a common congenital malformation of the male external genitalia. We performed a genome-wide association study using pooled DNA from 436 individuals with hypospadias (cases) a... |
1294 | There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors. | [
{
"docid": "2078658",
"title": "Oct4 links multiple epigenetic pathways to the pluripotency network",
"text": "Oct4 is a well-known transcription factor that plays fundamental roles in stem cell self-renewal, pluripotency, and somatic cell reprogramming. However, limited information is available on Oct4... | [
{
"docid": "4896726",
"title": "Pioneer factor Pax7 deploys a stable enhancer repertoire for specification of cell fate",
"text": "Pioneer transcription factors establish new cell-fate competence by triggering chromatin remodeling. However, many features of pioneer action, such as their kinetics and sta... |
1295 | There is no relation between Erythromycin use and hypertrophic pyloric stenosis. | [
{
"docid": "21239672",
"title": "Use of macrolides in mother and child and risk of infantile hypertrophic pyloric stenosis: nationwide cohort study",
"text": "OBJECTIVE To assess the association between use of macrolide antibiotics in mothers and infants from pregnancy onset until 120 days after birth a... | [
{
"docid": "27550580",
"title": "T1 mapping for myocardial extracellular volume measurement by CMR: bolus only versus primed infusion technique.",
"text": "OBJECTIVES The aim of this study was to determine the accuracy of the contrast \"bolus only\" T1 mapping cardiac magnetic resonance (CMR) technique ... |
1297 | There was an estimated 30 million cases of pneumonia in young children worldwide in 2010. | [
{
"docid": "9167230",
"title": "Global and regional burden of hospital admissions for severe acute lower respiratory infections in young children in 2010: a systematic analysis",
"text": "BACKGROUND The annual number of hospital admissions and in-hospital deaths due to severe acute lower respiratory inf... | [
{
"docid": "20999249",
"title": "Imported malaria in children: a national surveillance in the Netherlands and a review of European studies.",
"text": "BACKGROUND Falciparum malaria or malaria tropica is one of the leading causes of childhood mortality worldwide. Malaria-related deaths occur mainly in su... |
1300 | Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides. | [
{
"docid": "6421792",
"title": "Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL",
"text": "Acute lymphoblastic leukemia (ALL) is an aggressive hematological tumor resulting from the malignant transformation of lymphoid progenitors. Despite intensive chem... | [
{
"docid": "1373287",
"title": "Prognostic importance of 6-mercaptopurine dose intensity in acute lymphoblastic leukemia.",
"text": "6-Mercaptopurine (6MP) and methotrexate are the backbone of continuation therapy for childhood acute lymphoblastic leukemia (ALL). In studies of oral 6MP and methotrexate,... |
1302 | Tirasemtiv has no effect on cardiac muscle. | [
{
"docid": "12631697",
"title": "Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases",
"text": "Limited neural input results in muscle weakness in neuromuscular disease because of a reduction in the density of muscle innervation, the rate o... | [
{
"docid": "37673301",
"title": "Peptide and non-peptide G-protein coupled receptors (GPCRs) in skeletal muscle.",
"text": "G-protein coupled receptors (GPCRs) represent a large class of cell surface receptors that mediate a multitude of functions. Over the years, a number of GPCRs and ancillary protein... |
1304 | Tirasemtiv targets cardiac muscle. | [
{
"docid": "12631697",
"title": "Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases",
"text": "Limited neural input results in muscle weakness in neuromuscular disease because of a reduction in the density of muscle innervation, the rate o... | [
{
"docid": "106301",
"title": "Cardiac neural crest cells contribute to the dormant multipotent stem cell in the mammalian heart",
"text": "Arodent cardiac side population cell fraction formed clonal spheroids in serum-free medium, which expressed nestin, Musashi-1, and multi-drug resistance transporter... |
1305 | Tirasemtiv targets fast-twitch muscle. | [
{
"docid": "12631697",
"title": "Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases",
"text": "Limited neural input results in muscle weakness in neuromuscular disease because of a reduction in the density of muscle innervation, the rate o... | [
{
"docid": "40631095",
"title": "The Combination of Exercise and Respiratory Training Improves Respiratory Muscle Function in Pulmonary Hypertension",
"text": "Increased dyspnea and reduced exercise capacity in pulmonary arterial hypertension (PAH) can be partly attributed to impaired respiratory muscle... |
1306 | Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS. | [
{
"docid": "6000423",
"title": "The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype.",
"text": "Despite genetic heterogeneity, myelodysplastic syndromes (MDSs) share features of cytological dysplasia and ineffective hematopoiesis. We report that a hallmark of MDSs is a... | [
{
"docid": "3616843",
"title": "Association of Toll-Like Receptor 4 on Human Monocyte Subsets and Vulnerability Characteristics of Coronary Plaque as Assessed by 64-Slice Multidetector Computed Tomography.",
"text": "BACKGROUND Although Toll-like receptor 4 (TLR-4) is involved in monocyte activation in ... |
1307 | Tonic signaling from the scFv induces constitutive stimulation. | [
{
"docid": "18231807",
"title": "4-1BB Costimulation Ameliorates T Cell Exhaustion Induced by Tonic Signaling of Chimeric Antigen Receptors",
"text": "Chimeric antigen receptors (CARs) targeting CD19 have mediated dramatic antitumor responses in hematologic malignancies, but tumor regression has rarely ... | [
{
"docid": "34016944",
"title": "Resistance to gefitinib in PTEN-null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3'-kinase/Akt pathway signaling.",
"text": "PURPOSE Tyrosine kinase (TK) inhibitors a... |
1308 | Tonic signaling from the scFv is amplified by MyD88/CD40. | [
{
"docid": "18231807",
"title": "4-1BB Costimulation Ameliorates T Cell Exhaustion Induced by Tonic Signaling of Chimeric Antigen Receptors",
"text": "Chimeric antigen receptors (CARs) targeting CD19 have mediated dramatic antitumor responses in hematologic malignancies, but tumor regression has rarely ... | [
{
"docid": "2734421",
"title": "The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.",
"text": "Medullary thymic epithelial cells (mTECs) establish T cell self-tolerance through the expression of autoimmune regulator (... |
1309 | Tonic signaling from the scFv prevents constitutive stimulation. | [
{
"docid": "18231807",
"title": "4-1BB Costimulation Ameliorates T Cell Exhaustion Induced by Tonic Signaling of Chimeric Antigen Receptors",
"text": "Chimeric antigen receptors (CARs) targeting CD19 have mediated dramatic antitumor responses in hematologic malignancies, but tumor regression has rarely ... | [
{
"docid": "13639330",
"title": "Histone Methylation-Dependent Mechanisms Impose Ligand Dependency for Gene Activation by Nuclear Receptors",
"text": "Nuclear receptors undergo ligand-dependent conformational changes that are required for corepressor-coactivator exchange, but whether there is an actual ... |
1310 | Traditional reviews are biased in their interpretations. | [
{
"docid": "8042158",
"title": "Systematic reviews from astronomy to zoology: myths and misconceptions.",
"text": "Systematic literature reviews are widely used as an aid to evidence based decision making. For example, reviews of randomised controlled trials are regularly used to answer questions about ... | [
{
"docid": "27138601",
"title": "Free water elimination diffusion tractography: A comparison with conventional and fluid-attenuated inversion recovery, diffusion tensor imaging acquisitions.",
"text": "PURPOSE White matter tractography reconstructions using conventional diffusion tensor imaging (DTI) ne... |
1311 | Trans-acting factors, such as lncRNAs, influence mRNA translation. | [
{
"docid": "13763195",
"title": "LincRNA-p21 suppresses target mRNA translation.",
"text": "Mammalian long intergenic noncoding RNAs (lincRNAs) are best known for modulating transcription. Here we report a posttranscriptional function for lincRNA-p21 as a modulator of translation. Association of the RNA... | [
{
"docid": "26378103",
"title": "The structure and expression of a novel gene activated in early mouse embryogenesis.",
"text": "We report the cloning and sequence determination of the mouse H19 gene. This gene is under the genetic control of two trans-acting loci in the mouse, termed raf and Rif. These... |
1312 | Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus. | [
{
"docid": "24177706",
"title": "Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes.",
"text": "Animal host defense against infection requires the expression of defense genes at the right place and the right time. Understanding such tight control of host d... | [
{
"docid": "45401535",
"title": "Candida albicans-Staphylococcus aureus polymicrobial peritonitis modulates host innate immunity.",
"text": "Despite advances in medical device fabrication and antimicrobial treatment therapies, fungal-bacterial polymicrobial peritonitis remains a serious complication for... |
1314 | Transcription rates in S. cerevisiae range between 0.7 and 2 kb/min. | [
{
"docid": "13072112",
"title": "Distinction and relationship between elongation rate and processivity of RNA polymerase II in vivo.",
"text": "A number of proteins and drugs have been implicated in the process of transcriptional elongation by RNA polymerase (Pol) II, but the factors that govern the elo... | [
{
"docid": "43566999",
"title": "Exercise blood flow patterns within and among rat muscles after training.",
"text": "This study was designed to determine the influence of a long-term, moderate-intensity treadmill training program on the distribution of blood flow within and among muscles of rats during... |
1315 | Transcription rates in S. cerevisiae range between 7 and 12 kb/min. | [
{
"docid": "13072112",
"title": "Distinction and relationship between elongation rate and processivity of RNA polymerase II in vivo.",
"text": "A number of proteins and drugs have been implicated in the process of transcriptional elongation by RNA polymerase (Pol) II, but the factors that govern the elo... | [
{
"docid": "29788648",
"title": "NuA4 lysine acetyltransferase Esa1 is targeted to coding regions and stimulates transcription elongation with Gcn5.",
"text": "NuA4, the major H4 lysine acetyltransferase (KAT) complex in Saccharomyces cerevisiae, is recruited to promoters and stimulates transcription in... |
1322 | Transplanted human glial progenitor cells can mature in their host animal. | [
{
"docid": "16284655",
"title": "Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice.",
"text": "Human astrocytes are larger and more complex than those of infraprimate mammals, suggesting that their role in neural processing has expanded with ev... | [
{
"docid": "14192687",
"title": "Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease.",
"text": "The long-term goal of nuclear transfer or alternative reprogramming approaches is to create patient-specific donor ... |
1323 | Treatment with a protein named FN impairs regenerative abilities of aged muscles. | [
{
"docid": "19912367",
"title": "Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice",
"text": "Age-related changes in the niche have long been postulated to impair the function of somatic stem cells. Here we demonstrate that the aged stem cell ... | [
{
"docid": "20418809",
"title": "Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia",
"text": "A key determinant of geriatric frailty is sarcopenia, the age-associated loss of skeletal muscle mass and strength. Although the e... |
1324 | Treatment with a protein named FN restores regenerative abilities of aged muscles. | [
{
"docid": "19912367",
"title": "Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice",
"text": "Age-related changes in the niche have long been postulated to impair the function of somatic stem cells. Here we demonstrate that the aged stem cell ... | [
{
"docid": "4326318",
"title": "Rejuvenation of aged progenitor cells by exposure to a young systemic environment",
"text": "The decline of tissue regenerative potential is a hallmark of ageing and may be due to age-related changes in tissue-specific stem cells. A decline in skeletal muscle stem cell (s... |
1325 | Treatment with the EC uptake inhibitor AM404 resulted in a dose-dependent decrease in the expression of immobility. | [
{
"docid": "40476126",
"title": "Functional role of high-affinity anandamide transport, as revealed by selective inhibition.",
"text": "Anandamide, an endogenous ligand for central cannabinoid receptors, is released from neurons on depolarization and rapidly inactivated. Anandamide inactivation is not c... | [
{
"docid": "10207180",
"title": "β-site amyloid precursor protein-cleaving enzyme 1(BACE1) inhibitor treatment induces Aβ5-X peptides through alternative amyloid precursor protein cleavage",
"text": "INTRODUCTION The β-secretase enzyme, β-site amyloid precursor protein-cleaving enzyme 1 (BACE1), cleaves... |
1327 | Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK. | [
{
"docid": "24241932",
"title": "Ecological analysis of ethnic differences in relation between tuberculosis and poverty.",
"text": "OBJECTIVE To examine the effect of ethnicity on the relation between tuberculosis and deprivation. \n DESIGN Retrospective ecological study comparing incidence of tubercu... | [
{
"docid": "7111021",
"title": "Integration of antiretroviral therapy with tuberculosis treatment.",
"text": "BACKGROUND We previously reported that integrating antiretroviral therapy (ART) with tuberculosis treatment reduces mortality. However, the timing for the initiation of ART during tuberculosis t... |
1328 | Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue. | [
{
"docid": "3475317",
"title": "Inflammatory signaling in human Tuberculosis granulomas is spatially organized",
"text": "Granulomas are the pathological hallmark of tuberculosis (TB). However, their function and mechanisms of formation remain poorly understood. To understand the role of granulomas in T... | [
{
"docid": "34615397",
"title": "Human tuberculous granulomas induce peripheral lymphoid follicle-like structures to orchestrate local host defence in the lung.",
"text": "The human tuberculous granuloma provides the morphological basis for local immune processes central to the outcome of tuberculosis. ... |
1330 | Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines. | [
{
"docid": "14075252",
"title": "Paraneoplastic thrombocytosis: the secrets of tumor self-promotion.",
"text": "Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between ... | [
{
"docid": "21382907",
"title": "Reduced Cytokine Release in Ex Vivo Response to Cilengitide and Cetuximab Is a Marker for Improved Survival of Head and Neck Cancer Patients",
"text": "Targeting of αVβ3 and αVβ5 integrins by cilengitide may reduce growth of solid tumors including head and neck squamous ... |
1331 | Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines. | [
{
"docid": "14075252",
"title": "Paraneoplastic thrombocytosis: the secrets of tumor self-promotion.",
"text": "Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between ... | [
{
"docid": "8702697",
"title": "miR-205 hinders the malignant interplay between prostate cancer cells and associated fibroblasts.",
"text": "AIMS Tumor microenvironment is a strong determinant for the acquisition of metastatic potential of cancer cells. We have recently demonstrated that cancer-associat... |
1333 | Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients. | [
{
"docid": "1649738",
"title": "Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma",
"text": "Survivors of pediatric Hodgkin's lymphoma are at risk for radiation therapy–induced second malignant neoplasms (SMNs). We identified two variants at... | [
{
"docid": "6559701",
"title": "Regulation of the latent-lytic switch in Epstein-Barr virus.",
"text": "Epstein-Barr virus (EBV) infection contributes to the development of several different types of human malignancy, including Burkitt lymphoma, Hodgkin lymphoma, and nasopharyngeal carcinoma. As a herpe... |
1334 | Type 1 Diabetes is associated with subtle perturbations in T reg development. | [
{
"docid": "13923140",
"title": "Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity",
"text": "Autoimmune diseases are thought to result from imbalances in normal immune physiology and regulation. Here, we show that autoimmune disease susceptibility and resistance al... | [
{
"docid": "266641",
"title": "CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells",
"text": "Regulatory T (T reg) cells are critical regulators of immune tolerance. Most T reg cells are defined based on expression of CD4, CD25, and the transcription facto... |
1340 | Ultrasound guidance significantly reduces the number of needle insertion attempts necessary for a given procedure. | [
{
"docid": "15482274",
"title": "Ultrasound imaging for lumbar punctures and epidural catheterisations: systematic review and meta-analysis.",
"text": "OBJECTIVE To determine whether ultrasound imaging can reduce the risk of failed lumbar punctures or epidural catheterisations, when compared with standa... | [
{
"docid": "52874170",
"title": "How do I perform a lumbar puncture and analyze the results to diagnose bacterial meningitis?",
"text": "CONTEXT Diagnostic lumbar punctures (LPs), commonly used to rule out meningitis, are associated with adverse events. \n OBJECTIVE To systematically review the eviden... |
1341 | Ultrasound guidance significantly reduces the number of traumatic procedures when attempting needle insertion. | [
{
"docid": "15482274",
"title": "Ultrasound imaging for lumbar punctures and epidural catheterisations: systematic review and meta-analysis.",
"text": "OBJECTIVE To determine whether ultrasound imaging can reduce the risk of failed lumbar punctures or epidural catheterisations, when compared with standa... | [
{
"docid": "52874170",
"title": "How do I perform a lumbar puncture and analyze the results to diagnose bacterial meningitis?",
"text": "CONTEXT Diagnostic lumbar punctures (LPs), commonly used to rule out meningitis, are associated with adverse events. \n OBJECTIVE To systematically review the eviden... |
1342 | Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors. | [
{
"docid": "8148122",
"title": "Global Reorganization of Replication Domains During Embryonic Stem Cell Differentiation",
"text": "DNA replication in mammals is regulated via the coordinate firing of clusters of replicons that duplicate megabase-sized chromosome segments at specific times during S-phase... | [
{
"docid": "4037034",
"title": "Development of a novel helper-dependent adenovirus-Epstein-Barr virus hybrid system for the stable transformation of mammalian cells.",
"text": "Epstein-Barr virus (EBV) episomes are stably maintained in permissive proliferating cell lines due to EBV nuclear antigen 1 (EB... |
1345 | Up-regulation of the p53 pathway and related molecular events speeds cancer progression. | [
{
"docid": "9559146",
"title": "Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors",
"text": "Cells from organisms with renewable tissues can permanently withdraw from the cell cycle in response to diverse stress, including dysfunctional telomeres, DNA damage, strong ... | [
{
"docid": "28249680",
"title": "BAX/BAK-independent mitoptosis during cell death induced by proteasome inhibition?",
"text": "Proteasome inhibitors induce rapid death of cancer cells. We show that in epithelial cancer cells, such death is associated with dramatic and simultaneous up-regulation of sever... |
1346 | Upon developing tyrosine-kinase inhibitor resistance, new mutations in epidermal growth factor receptors emerge and cause treatment failure. | [
{
"docid": "9505402",
"title": "Acquired EGFR C797S mutation mediates resistance to AZD9291 in non–small cell lung cancer harboring EGFR T790M",
"text": "Here we studied cell-free plasma DNA (cfDNA) collected from subjects with advanced lung cancer whose tumors had developed resistance to the epidermal ... | [
{
"docid": "9929089",
"title": "Subsequent chemotherapy reverses acquired tyrosine kinase inhibitor resistance and restores response to tyrosine kinase inhibitor in advanced non-small-cell lung cancer",
"text": "BACKGROUND Patients with advanced or metastatic non-small cell lung cancer (NSCLC) can devel... |
1347 | Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung. | [
{
"docid": "19005293",
"title": "Memory CD4+ T cells induce innate responses independently of pathogen",
"text": "Inflammation induced by recognition of pathogen-associated molecular patterns markedly affects subsequent adaptive responses. We asked whether the adaptive immune system can also affect the ... | [
{
"docid": "3835423",
"title": "CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection.",
"text": "Tissue-resident memory T (Trm) cells provide enhanced protection against infection at mucosal sites. Here we found that CD4(+) T cells are important ... |
1348 | Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung. | [
{
"docid": "19005293",
"title": "Memory CD4+ T cells induce innate responses independently of pathogen",
"text": "Inflammation induced by recognition of pathogen-associated molecular patterns markedly affects subsequent adaptive responses. We asked whether the adaptive immune system can also affect the ... | [
{
"docid": "3835423",
"title": "CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection.",
"text": "Tissue-resident memory T (Trm) cells provide enhanced protection against infection at mucosal sites. Here we found that CD4(+) T cells are important ... |
1349 | Upregulation of PD1 causes the downmodulation of Satb1. | [
{
"docid": "5377642",
"title": "SATB1 Expression Governs Epigenetic Repression of PD‐1 in Tumor‐Reactive T Cells",
"text": "&NA; Despite the importance of programmed cell death‐1 (PD‐1) in inhibiting T cell effector activity, the mechanisms regulating its expression remain poorly defined. We found that ... | [
{
"docid": "3981033",
"title": "IAP antagonists induce anti-tumor immunity in multiple myeloma",
"text": "The cellular inhibitors of apoptosis (cIAP) 1 and 2 are amplified in about 3% of cancers and have been identified in multiple malignancies as being potential therapeutic targets as a result of their... |
1350 | Upregulation of PD1 causes the upregulation of Satb1. | [
{
"docid": "5377642",
"title": "SATB1 Expression Governs Epigenetic Repression of PD‐1 in Tumor‐Reactive T Cells",
"text": "&NA; Despite the importance of programmed cell death‐1 (PD‐1) in inhibiting T cell effector activity, the mechanisms regulating its expression remain poorly defined. We found that ... | [
{
"docid": "3981033",
"title": "IAP antagonists induce anti-tumor immunity in multiple myeloma",
"text": "The cellular inhibitors of apoptosis (cIAP) 1 and 2 are amplified in about 3% of cancers and have been identified in multiple malignancies as being potential therapeutic targets as a result of their... |
1351 | Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron. | [
{
"docid": "28369117",
"title": "Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons",
"text": "Axons and dendrites differ in both microtubule organization and in the organelles and proteins they contain. Here we show that the microtubule motor dynein has a ... | [
{
"docid": "21598000",
"title": "Structural basis for the activation of microtubule assembly by the EB1 and p150Glued complex.",
"text": "Plus-end tracking proteins, such as EB1 and the dynein/dynactin complex, regulate microtubule dynamics. These proteins are thought to stabilize microtubules by formin... |
1353 | Urbanization is an important risk factor related to the transmission of dengue fever. | [
{
"docid": "18816720",
"title": "Spatial and Temporal Clustering of Dengue Virus Transmission in Thai Villages",
"text": "BACKGROUND Transmission of dengue viruses (DENV), the leading cause of arboviral disease worldwide, is known to vary through time and space, likely owing to a combination of factors ... | [
{
"docid": "2097256",
"title": "Population Density, Water Supply, and the Risk of Dengue Fever in Vietnam: Cohort Study and Spatial Analysis",
"text": "BACKGROUND Aedes aegypti, the major vector of dengue viruses, often breeds in water storage containers used by households without tap water supply, and ... |
1355 | V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress. | [
{
"docid": "5256564",
"title": "Pharmacological Blockade of ASCT2-dependent Glutamine Transport Leads To Anti-tumor Efficacy in Preclinical Models",
"text": "The unique metabolic demands of cancer cells underscore potentially fruitful opportunities for drug discovery in the era of precision medicine. Ho... | [
{
"docid": "24185667",
"title": "DAP kinase regulates JNK signaling by binding and activating protein kinase D under oxidative stress",
"text": "The stress-activated kinase JNK mediates key cellular responses to oxidative stress. Here we show that DAP kinase (DAPk), a cell death promoting Ser/Thr protei... |
1356 | Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa. | [
{
"docid": "13764090",
"title": "Large intestine-targeted nanoparticle-releasing oral vaccine to control genitorectal viral infection",
"text": "Both rectal and vaginal mucosal surfaces serve as transmission routes for pathogenic microorganisms. Vaccination through large intestinal mucosa, previously pr... | [
{
"docid": "708425",
"title": "Intermittent prophylaxis with oral truvada protects macaques from rectal SHIV infection.",
"text": "HIV continues to spread globally, mainly through sexual contact. Despite advances in treatment and care, preventing transmission with vaccines or microbicides has proven dif... |
1360 | Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion. | [
{
"docid": "11614737",
"title": "Combination varenicline and bupropion SR for tobacco-dependence treatment in cigarette smokers: a randomized trial.",
"text": "IMPORTANCE Combining pharmacotherapies for tobacco-dependence treatment may increase smoking abstinence. \n OBJECTIVE To determine efficacy an... | [
{
"docid": "5114940",
"title": "Pharmacological interventions for smoking cessation: an overview and network meta-analysis.",
"text": "BACKGROUND Smoking is the leading preventable cause of illness and premature death worldwide. Some medications have been proven to help people to quit, with three licens... |
1361 | Varying expression levels of EBI2 affect the positioning and migration of B cells. | [
{
"docid": "15488881",
"title": "Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses.",
"text": "Humoral immunity depends on both rapid and long-term antibody production against invading pathogens. This is achieved by the generation of spatially distinct ext... | [
{
"docid": "38587347",
"title": "Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses.",
"text": "Humoral immune responses depend on B cells encountering antigen, interacting with helper T cells, proliferating and differentiating into low-affinity plasma cells ... |
1364 | Venules have less significant tunica adventitia than arterioles. | [
{
"docid": "8290953",
"title": "Scaffold-based three-dimensional human fibroblast culture provides a structural matrix that supports angiogenesis in infarcted heart tissue.",
"text": "BACKGROUND We have developed techniques to implant angiogenic patches onto the epicardium over regions of infarcted card... | [
{
"docid": "1122279",
"title": "Endothelium-mediated relaxation of porcine collateral-dependent arterioles is improved by exercise training.",
"text": "BACKGROUND Endothelium-dependent modulation of coronary tone is impaired in the collateral-dependent coronary microcirculation. We used a porcine model ... |
1366 | VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus. | [
{
"docid": "4406819",
"title": "PAAR-repeat proteins sharpen and diversify the Type VI secretion system spike",
"text": "The bacterial type VI secretion system (T6SS) is a large multicomponent, dynamic macromolecular machine that has an important role in the ecology of many Gram-negative bacteria. T6SS ... | [
{
"docid": "27731651",
"title": "A view to a kill: the bacterial type VI secretion system.",
"text": "The bacterial type VI secretion system (T6SS) is an organelle that is structurally and mechanistically analogous to an intracellular membrane-attached contractile phage tail. Recent studies determined t... |
1367 | Vitamin D deficiency effects birth weight. | [
{
"docid": "2425364",
"title": "Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies.",
"text": "OBJECTIVE To assess the effect of 25-hydroxyvitamin D (25-OHD) levels on pregnancy outcomes and birth... | [
{
"docid": "13312471",
"title": "Vitamin D insufficiency and the blunted PTH response in established osteoporosis: the role of magnesium deficiency",
"text": "Vitamin D insufficiency is common, however within individuals, not all manifest the biochemical effects of PTH excess. This further extends to pa... |
1371 | Vitamin D is an important factor in the relationship between calcium and parathyroid hormone. | [
{
"docid": "16256507",
"title": "Relationship between serum parathyroid hormone levels, vitamin D sufficiency, and calcium intake.",
"text": "CONTEXT Adequate vitamin D status for optimum bone health has received increased recognition in recent years; however, the ideal intake is not known. Serum 25-hyd... | [
{
"docid": "23267371",
"title": "Vitamin D: The \"sunshine\" vitamin.",
"text": "Vitamin D insufficiency affects almost 50% of the population worldwide. An estimated 1 billion people worldwide, across all ethnicities and age groups, have a vitamin D deficiency (VDD). This pandemic of hypovitaminosis D c... |
1372 | Walking in traffic areas in London did not improve lung function in elderly adults. | [
{
"docid": "21003930",
"title": "Respiratory and cardiovascular responses to walking down a traffic-polluted road compared with walking in a traffic-free area in participants aged 60 years and older with chronic lung or heart disease and age-matched healthy controls: a randomised, crossover study",
"tex... | [
{
"docid": "53779698",
"title": "Exercise as a therapeutic approach to improve blood pressure in patients with peripheral arterial disease: current literature and future directions.",
"text": "INTRODUCTION Patients with symptomatic peripheral artery disease (PAD) exhibit reduced functional capacity and ... |
1373 | Walking in traffic areas in London improves lung function in elderly adults. | [
{
"docid": "21003930",
"title": "Respiratory and cardiovascular responses to walking down a traffic-polluted road compared with walking in a traffic-free area in participants aged 60 years and older with chronic lung or heart disease and age-matched healthy controls: a randomised, crossover study",
"tex... | [
{
"docid": "53779698",
"title": "Exercise as a therapeutic approach to improve blood pressure in patients with peripheral arterial disease: current literature and future directions.",
"text": "INTRODUCTION Patients with symptomatic peripheral artery disease (PAD) exhibit reduced functional capacity and ... |
1374 | Weighed food records (WFR) result in high completion since they're cheap to run and impose low participant burden. | [
{
"docid": "21993510",
"title": "Accuracy of weighed dietary records in studies of diet and health.",
"text": "OBJECTIVE To provide an independent evaluation of seven day weighed dietary records, which are currently accepted as the most accurate technique for assessing habitual dietary intake in studies... | [
{
"docid": "21623140",
"title": "Comparison of dietary assessment methods in a Southern French population: use of weighed records, estimated-diet records and a food-frequency questionnaire",
"text": "Objective: The main objective of the study was to develop appropriate dietary assessment instruments for... |
1375 | Weighed food records (WFR) result in poor completion since they're costly to run and impose high participant burden. | [
{
"docid": "21993510",
"title": "Accuracy of weighed dietary records in studies of diet and health.",
"text": "OBJECTIVE To provide an independent evaluation of seven day weighed dietary records, which are currently accepted as the most accurate technique for assessing habitual dietary intake in studies... | [
{
"docid": "21623140",
"title": "Comparison of dietary assessment methods in a Southern French population: use of weighed records, estimated-diet records and a food-frequency questionnaire",
"text": "Objective: The main objective of the study was to develop appropriate dietary assessment instruments for... |
1376 | Whole brain radiotherapy increases the occurrence of new brain metastases. | [
{
"docid": "3944632",
"title": "Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial.",
"text": "CONTEXT In patients with brain metastases, it is unclear whether adding up-front whole-brain radiat... | [
{
"docid": "19408393",
"title": "Value of whole brain re-irradiation for brain metastases--single centre experience.",
"text": "AIMS There is controversy in published studies regarding the role of repeat whole brain radiation (WBRT) for previously irradiated brain metastases. The aim of our retrospectiv... |
1378 | Women are more susceptible to death due to pneumonia when compared to men. | [
{
"docid": "2488880",
"title": "Gender-dependent differences in outcome after the treatment of infection in hospitalized patients.",
"text": "CONTEXT While it is established that management strategies and outcomes differ by gender for many diseases, its effect on infection has not been adequately studie... | [
{
"docid": "33835579",
"title": "Pathology of postprimary tuberculosis in humans and mice: contradiction of long-held beliefs.",
"text": "Tuberculosis remains one of the world's leading infectious causes of death. Approximately 80% of all disease is due to postprimary (secondary) tuberculosis in the lun... |
1380 | Women with a lower birth weight are more likely to develop breast cancer later in life. | [
{
"docid": "16322674",
"title": "Birth Size and Breast Cancer Risk: Re-analysis of Individual Participant Data from 32 Studies",
"text": "BACKGROUND Birth size, perhaps a proxy for prenatal environment, might be a correlate of subsequent breast cancer risk, but findings from epidemiological studies have... | [
{
"docid": "5487448",
"title": "Birth weight and mammographic density among postmenopausal women in Sweden.",
"text": "Birth weight is a significant predictor of breast cancer risk in adult life and mammary gland mass could be an intermediate stage in this long process. We have studied the association o... |
1381 | YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis. | [
{
"docid": "13481880",
"title": "YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration",
"text": "Tissue regeneration requires dynamic cellular adaptation to the wound environment. It is currently unclear how this is orchestrated at the cellular level and how ... | [
{
"docid": "42782688",
"title": "VSL#3 probiotic upregulates intestinal mucosal alkaline sphingomyelinase and reduces inflammation.",
"text": "BACKGROUND Alkaline sphingomyelinase, an enzyme found exclusively in bile and the intestinal brush border, hydrolyzes sphingomyelin into ceramide, sphingosine an... |
1383 | aPKCz causes tumour suppression by affecting glutamine metabolism. | [
{
"docid": "17755060",
"title": "Control of Nutrient Stress-Induced Metabolic Reprogramming by PKCζ in Tumorigenesis",
"text": "Tumor cells have high-energetic and anabolic needs and are known to adapt their metabolism to be able to survive and keep proliferating under conditions of nutrient stress. We ... | [
{
"docid": "3831884",
"title": "Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway",
"text": "Cancer cells have metabolic dependencies that distinguish them from their normal counterparts. Among these dependencies is an increased use of the amino acid glutamine to fue... |
1386 | cSMAC formation represses weak ligand signalling. | [
{
"docid": "306006",
"title": "The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse.",
"text": "T cell activation is predicated on the interaction between the T cell receptor and peptide-major histocompatibility (pMHC) ligands. The factors that determine... | [
{
"docid": "9283422",
"title": "T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster.",
"text": "T cell receptor (TCR) signaling is initiated and sustained in microclusters; however, it's not known whether signaling al... |
1387 | eRNAs influence is linked to senescence, aging, and carcinogenesis. | [
{
"docid": "9669099",
"title": "eRNAs are required for p53-dependent enhancer activity and gene transcription.",
"text": "Binding within or nearby target genes involved in cell proliferation and survival enables the p53 tumor suppressor gene to regulate their transcription and cell-cycle progression. Us... | [
{
"docid": "15521377",
"title": "Keeping your senescent cells under control",
"text": "Cellular senescence is a stable form of cell-cycle arrest which is thought to limit the proliferative potential of premalignant cells [1]. The senescence phenotype was initially described by Hayflick and Moorhead in 1... |
1390 | mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes. | [
{
"docid": "2890952",
"title": "Mechanistic characterization of the sulfur-relay system for eukaryotic 2-thiouridine biogenesis at tRNA wobble positions",
"text": "The wobble modification in tRNAs, 5-methoxycarbonylmethyl-2-thiouridine (mcm(5)s(2)U), is required for the proper decoding of NNR codons in ... | [
{
"docid": "34498325",
"title": "A conserved modified wobble nucleoside (mcm5s2U) in lysyl-tRNA is required for viability in yeast.",
"text": "Transfer RNAs specific for Gln, Lys, and Glu from all organisms (except Mycoplasma) and organelles have a 2-thiouridine derivative (xm(5)s(2)U) as wobble nucleos... |
1391 | miR-142-5P is a known regulator of raised body temperature. | [
{
"docid": "6766459",
"title": "RBM3 regulates temperature sensitive miR-142–5p and miR-143 (thermomiRs), which target immune genes and control fever",
"text": "Fever is commonly used to diagnose disease and is consistently associated with increased mortality in critically ill patients. However, the mol... | [
{
"docid": "53211308",
"title": "Exosomal miR-99a-5p is elevated in sera of ovarian cancer patients and promotes cancer cell invasion by increasing fibronectin and vitronectin expression in neighboring peritoneal mesothelial cells",
"text": "BACKGROUND microRNAs (miRNAs) stably exist in circulating bloo... |
1392 | miR-142-5P is a temperature-sensitive microRNA (miRNA). | [
{
"docid": "6766459",
"title": "RBM3 regulates temperature sensitive miR-142–5p and miR-143 (thermomiRs), which target immune genes and control fever",
"text": "Fever is commonly used to diagnose disease and is consistently associated with increased mortality in critically ill patients. However, the mol... | [
{
"docid": "53211308",
"title": "Exosomal miR-99a-5p is elevated in sera of ovarian cancer patients and promotes cancer cell invasion by increasing fibronectin and vitronectin expression in neighboring peritoneal mesothelial cells",
"text": "BACKGROUND microRNAs (miRNAs) stably exist in circulating bloo... |
1393 | miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription. | [
{
"docid": "2000038",
"title": "MicroRNAs can generate thresholds in target gene expression",
"text": "MicroRNAs (miRNAs) are short, highly conserved noncoding RNA molecules that repress gene expression in a sequence-dependent manner. We performed single-cell measurements using quantitative fluorescence... | [
{
"docid": "16086778",
"title": "Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis",
"text": "The biological antagonism between Notch and Numb controls the proliferative/differentiative balance in development and homeostasis. Although altered Notch signaling has b... |
1394 | miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells. | [
{
"docid": "2251426",
"title": "microRNAs: A Safeguard against Turmoil?",
"text": "Emerging data suggest that microRNAs (miRNAs) are instrumental in a variety of stress responses in addition to their more recognized role in development. Surprisingly, miRNAs, which normally suppress expression of target ... | [
{
"docid": "12582729",
"title": "Flow-Dependent Regulation of Kruppel-Like Factor 2 Is Mediated by MicroRNA-92a.",
"text": "BACKGROUND Upregulated by atheroprotective flow, the transcription factor Krüppel-like factor 2 (KLF2) is crucial for maintaining endothelial function. MicroRNAs (miRNAs) are nonco... |
1397 | p16INK4A degradation is linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs). | [
{
"docid": "17717391",
"title": "Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model",
"text": "Monitoring cancer and aging in vivo remains experimentally challenging. Here, we describe a luciferase knockin mouse (p16(LUC)), which faithfully reports expression of p16(INK4a),... | [
{
"docid": "22309946",
"title": "Asymptomatic spinal cord lesions predict disease progression in radiologically isolated syndrome.",
"text": "BACKGROUND Technological advancements in neuroimaging and the increased use of these diagnostic modalities are responsible for the discovery of incidentally ident... |
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