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1 | Case 1 | Courses of Treatment | Benign and Proliferative | Courses of Treatment. → 2022-02-11 Excision, Lt. (8H and 5H).. C. W. Lee · B. H. Choi (*). Department of Radiology, National Cancer Center,. Goyang, Republic of Korea. e-mail: cwlee@ncc.re.kr; iawy82@ncc.re.kr. Y. Kwon. Department of Radiology, Center for Breast Cancer, National. Cancer Center, Goyang, Gyeonggi, Republ... |
9 | Case 1 | Important Radiologic | Benign and Proliferative | Important Radiologic. Findings. 1. 2. 1.3. |
15 | Case 1 | Patient History | Benign and Proliferative | Patient History and Progress. Female/37 years old, pre-menopause.. Screen detected mass lesion on left breast. 8 o’clock and 5 o’clock direction.. Outside result of biopsy: Papillary neoplasm.. No family history.. No comorbidities.. 1.2. |
2 | Case 1 | Courses of Treatment | Carcinoma In Situ | Carcinoma In Situ. Eun Sook Lee, Chan Wha Lee, Youngmi Kwon,. Yunju Kim, and Bo Hwa Choi. 1. . 1.1. . Courses of Treatment. Operation + Postoperative radiation therapy +. Tamoxifen 20 mg/day for 5 years.. 1.3.1. . Operation. 5. 6. 1.3.2. . Pathology Report. Ductal carcinoma in situ, pathological TN cat. egory (AJC... |
10 | Case 1 | Important Radiologic | Carcinoma In Situ | Important Radiologic. Findings. 1 2 3. 4. E. S. Lee. Center for Breast Cancer, National Cancer Center,. Goyang, Kyonggi-do, Republic of Korea. e-mail: eslee@ncc.re.kr. C. W. Lee (*) · B. H. Choi. Division of Diagnostic Radiology, Center for Breast. Cancer, National Cancer Center,. Goyang, Republic of Korea. e-mail: cwl... |
16 | Case 1 | Patient History | Carcinoma In Situ | Patient History and Progress. Female/47 years old, pre-menopause.. Screen detected a mass lesion on left breast in. 10 o’clock direction.. No family history of breast cancer or other. cancers.. S/P Uterine myomectomy.. 1.2. |
3 | Case 1 | Courses of Treatment | HR(+) HER2(+) Breast Cancer | . 1.1. . Courses of Treatment. Neoadjuvant chemotherapy (#6 cycles of. docetaxel and carboplatin and trastuzumab. and pertuzumab) + Operation + Post-. operative radiation therapy + Tamoxifen. 20 mg/day.. 7. 1.3.1. . Pathology Report. Invasive Ductal Carcinoma. 1. Post-chemotherapy status.. 2. Size of invasi... |
11 | Case 1 | Important Radiologic | HR(+) HER2(+) Breast Cancer | Important Radiologic. Findings. 1 2 3 4 5. 6. 1.3. |
17 | Case 1 | Patient History | HR(+) HER2(+) Breast Cancer | Patient History and Progress. Female/47 years old, pre-menopause.. Screen detected mass lesion on left breast 5. o’clock direction.. No family history.. No comorbidities.. 1.2. |
4 | Case 1 | Courses of Treatment | HR(+) HER2(-) Breast Cancer | HR(+) HER2(−) Breast Cancer. Yunju Kim, Bo Hwa Choi, Eun-Gyeong Lee,. Ji Young You, and Youngmi Kwon. 1. . 1.1. . Courses of Treatment. Operation + Letrozole 2.5 mg/day. 1.3.1. . Operation. Left total mastectomy, sentinel lymph node. 2. Histologic grade: 2/3 (tubule formation: 2/3,. nuclear pleomorphism: 2/3, mitot... |
12 | Case 1 | Important Radiologic | HR(+) HER2(-) Breast Cancer | Important Radiologic. Findings. See Figs. 1, 2 and 3.. 1.3. |
18 | Case 1 | Patient History | HR(+) HER2(-) Breast Cancer | Patient History and Progress. Female/87 years old, post-menopause.. Screen detected mass lesion on left breast sub. areolar area.. No family history.. Hypertension, diabetes mellitus, arrhythmia,. total knee replacement, cerebrovascular accident.. 1.2. |
5 | Case 1 | Courses of Treatment | HR(−) HER2(+) Breast Cancer | HR(−) HER2(+) Breast Cancer. Youngmi Kwon, Yunju Kim, Bo Hwa Choi,. Ji Young You, Ran Song, Jeayeon Woo,. and Soojin Park. 1. . 1.1. . pertuzumab) + Operation + Post-operative radia. tion therapy + Trastuzumab.. Result. Intensity. Positive %. Estrogen. receptor. Negative (0/8). 0. 0. Progesterone. receptor. Negative... |
13 | Case 1 | Important Radiologic | HR(−) HER2(+) Breast Cancer | Important Radiologic Findings. 1 2 3. 4. Y. Kwon. Department of Radiology, Center for Breast Cancer,. National Cancer Center, Goyang, Gyeonggi,. Republic of Korea. e-mail: ymk@ncc.re.kr. Y. Kim. Department of Pathology, National Cancer Center,. Goyang, Gyeonggi, Republic of Korea. e-mail: radkyj@ncc.re.kr. B. H. Choi. ... |
19 | Case 1 | Patient History | HR(−) HER2(+) Breast Cancer | Patient History and Progress. Female/59 years old, post-menopause.. Self-detected mass lesion on right breast 12. o’clock direction.. No family history.. S/P Tuberculosis.. 1.2. |
6 | Case 1 | Courses of Treatment | HR(−) HER2(−) Breast Cancer | HR(−) HER2(−) Breast Cancer. Eun Sook Lee, Chan Wha Lee, Youngmi Kwon,. Jeayeon Woo, and Yunju Kim. 1. . 1.1. . Courses of Treatment. Neoadjuvant chemotherapy (#4 cycles of. doxorubicin. and. cyclophosphamide. +. #4 cycles of docetaxel) + Operation + Post-. operative radiation therapy.. 1.3.1. . Operation. 7. 1.3.... |
14 | Case 1 | Important Radiologic | HR(−) HER2(−) Breast Cancer | Important Radiologic Findings. 1 2. 3. E. S. Lee. Center for Breast Cancer, National Cancer Center,. Goyang, Kyonggi-do, Republic of Korea. e-mail: eslee@ncc.re.kr. C. W. Lee. Division of Diagnostic Radiology, Center for Breast Cancer,. National Cancer Center, Goyang, Republic of Korea. e-mail: drlee4958@gmail.com. Y. ... |
20 | Case 1 | Patient History | HR(−) HER2(−) Breast Cancer | Patient History and Progress. Female/40 years old, pre-menopause.. Screen detected a mass lesion at 1 o’clock. direction of the left breast.. No family history.. No comorbidities.. BRCA 1 and 2 mutation: Not detected,. CHEK2 VUS (variant of uncertain).. 1.2. |
7 | Case 1 | Courses of Treatment | Local Recurrence | Local Recurrence. Yunju Kim, Eun-Gyeong Lee, Ran Song,. and Eun Sook Lee. 1. . 1.1. . Courses of Treatment. Right breast IDC → Neoadjuvant chemotherapy. → Operation → Adjuvant therapy → Right. breast recurrence (IDC).. 1.2.1. . Primary Treatment. 1 2 3. 4. Neoadjuvant Chemotherapy. Neoadjuvant chemotherapy #4 cycles... |
21 | Case 1 | Patient History | Local Recurrence | Patient History and Progress. Female/41 years old, pre-menopause.. Screen detected mass lesion on lower medial. and lower outer portion of right breast.. Family history of breast cancer, maternal aunt.. No comorbidities.. BRCA 1 and 2 mutation: Not detected.. 1.2. |
8 | Case 1 | Courses of Treatment | Metastatic Breast Cancer | Metastatic Breast Cancer. Youngmi Kwon, Yunju Kim, Bo Hwa Choi,. Eun-Gyeong Lee, Ji Young You, and Eun Sook Lee. 1. . 1.1. . Courses of Treatment. Left breast cancer → Operation + Adjuvant. therapy → Chest wall recurrence → Palliative. therapy. →. Pleural. fissure. recur. rence → Palliative therapy.. 1.2.1. . P... |
22 | Case 1 | Patient History | Metastatic Breast Cancer | Patient History and Progress. Female/49 years old, post-menopause.. No family history.. 1.2. |
23 | Case 10 | Courses of Treatment | Benign and Proliferative | Courses of Treatment. →2021-11-09 excision (Lt. 3H SA, Lt. nipple. mass).. Pathology Report. • Breast, “left subareolar 3 o’clock”, excision:. –. – Atypical ductal hyperplasia.. • Breast, “left nipple mass,” excision:. –. – Nipple adenoma (florid papillomatosis).. . . C. W. Lee et al.. 29. . . 11. |
31 | Case 10 | Important Radiologic | Benign and Proliferative | Important Radiologic. Findings. 16. 17. 10.3. |
37 | Case 10 | Patient History | Benign and Proliferative | Bloody discharge from left nipple.. No family history.. No comorbidities.. 10.2. |
24 | Case 10 | Courses of Treatment | Carcinoma In Situ | 10.1. . Courses of Treatment. Operation + Tamoxifen 20 mg/day for 5 years.. Operation. 47. 48. Pathology Report. Ductal carcinoma in situ, pathological TN cat. egory (AJCC 2017): pTisN0(sn). . 1. Size of tumor: 2.0 cm (pTis).. . 2. Nuclear grade: low.. . 3. Necrosis: absent.. . 4. Architectural pattern: solid.. .... |
32 | Case 10 | Important Radiologic | Carcinoma In Situ | Important Radiologic. Findings. 43 44 45. 46. 10.3. |
38 | Case 10 | Patient History | Carcinoma In Situ | Patient History and Progress. Female/52 years old, pre-menopause.. Screen detected microcalcification on mid. inner portion left breast.. Outside result of biopsy:. Left 9:30 o’clock, ductal carcinoma in situ.. Right 11 o’clock, flat epithelial atypia with. microcalcification.. No family history.. BRCA 1 and 2 mutatio... |
25 | Case 10 | Courses of Treatment | HR(+) HER2(+) Breast Cancer | 10.1. . Courses of Treatment. Neoadjuvant chemotherapy (#6 cycles of. docetaxel and carboplatin and trastuzumab. and pertuzumab) + Operation + Post-. operative radiation therapy + Trastuzumab. emtansine + Letrozole 2.5 mg/day with. goserelin.. S. Park et al.. 329. . . . HR(+) HER2(+) Breast Cancer. 330. . 5... |
33 | Case 10 | Important Radiologic | HR(+) HER2(+) Breast Cancer | Important Radiologic. Findings. 52 53 54 55 56. 57. 10.3. |
39 | Case 10 | Patient History | HR(+) HER2(+) Breast Cancer | Patient History and Progress. Female/32 years old, pre-menopause.. Self-detected skin changes and mass lesion on. left breast.. Family history of breast cancer, maternal aunt.. No comorbidities.. BRCA 1 and 2 mutation: Not detected, NBN. and PALB2 VUS (variant of uncertain).. 10.2. |
26 | Case 10 | Courses of Treatment | HR(+) HER2(-) Breast Cancer | Courses of Treatment. Operation. +. Adjuvant. chemotherapy. (#4 cycles of docetaxel & cyclophospha. mide). +. Post-operative. radiation. ther. apy + Tamoxifen 20 mg/day.. Operation. Left breast conserving surgery, axillary lymph. 5. Surgical margins:. . (a) superior margin: 10 mm,. . (b) inferior margin: 30 mm,. ... |
34 | Case 10 | Important Radiologic | HR(+) HER2(-) Breast Cancer | Important Radiologic. Findings. See Figs. 48, 49, 50 and 51.. 10.3. |
40 | Case 10 | Patient History | HR(+) HER2(-) Breast Cancer | No comorbidities.. 10.2. |
27 | Case 10 | Courses of Treatment | HR(−) HER2(+) Breast Cancer | 10.1. . Courses of Treatment. Neoadjuvant chemotherapy (#6 cycles of. docetaxel and carboplatin and trastuzumab and. pertuzumab) + Operation + Trastuzumab and. pertuzumab.. Operation. 77. a. b. . . Y. Kwon et al.. 469. Pathology Report. No residual tumor with stromal degeneration.. . 1. Post-chemotherapy status..... |
35 | Case 10 | Important Radiologic | HR(−) HER2(+) Breast Cancer | Important Radiologic. Findings. 69 70 71. 72. . . . HR(−) HER2(+) Breast Cancer. 466. . Y. Kwon et al.. 467. 10.3. . After Neoadjuvant. Chemotherapy. 73 74 75. 76. . . . . . HR(−) HER2(+) Breast Cancer. 468. 10.4. |
41 | Case 10 | Patient History | HR(−) HER2(+) Breast Cancer | Patient History and Progress. Female/36 years old, pre-menopause.. Self-detected palpable mass lesion on left. breast 9 o’clock direction.. Family history of breast cancer, aunt. (paternal).. S/P Tuberculosis, s/p salpingectomy.. BRCA 1 and 2 mutation: Not detected, ATM. VUS (variant of uncertain).. 10.2. |
28 | Case 10 | Courses of Treatment | HR(−) HER2(−) Breast Cancer | 10.1. . Courses of Treatment. Neoadjuvant chemotherapy (#4 cycles of. doxorubicin and cyclophosphamide + #4. cycles of paclitaxel and cisplatin) + Operation. + Post-operative radiation therapy + ada. gloxad simolenin plus capecitabine.. Operation. 73. E. S. Lee et al.. 609. . . . HR(−) HER2(−) Breast Cancer. 610... |
36 | Case 10 | Important Radiologic | HR(−) HER2(−) Breast Cancer | Important Radiologic. Findings. 66 67. 68. After Neoadjuvant. Chemotherapy. 69 70 71. 72. 10.3. |
42 | Case 10 | Patient History | HR(−) HER2(−) Breast Cancer | Patient History and Progress. Female/56 years old, post-menopause.. Self-detected palpable mass lesion on right. breast.. No family history.. Asthma.. 10.2. |
29 | Case 10 | Courses of Treatment | Local Recurrence | 10.1. . Courses of Treatment. Right breast IDC→ Operation → Adjuvant ther. apy → Right breast recurrence (IDC).. Primary Treatment. 76 77. 78. Operation. . . 79. 80. Pathology Report. . 1. Invasive ductal carcinoma.. . (a) Size of tumor: 1.8 cm (pT1c).. . (b) Histologic grade: 2/3 (tubule formation:. 3/3, nuclea... |
43 | Case 10 | Patient History | Local Recurrence | Patient History and Progress. Female/42 years old, pre-menopause.. Screen detected mass lesion on right breast 5. o’clock direction.. Outside result of biopsy: Invasive ductal. carcinoma.. No family history.. s/p myomectomy.. 10.2. |
30 | Case 10 | Courses of Treatment | Metastatic Breast Cancer | 10.1. . Courses of Treatment. Left breast cancer → Operation → Adjuvant. therapy → Ipsilateral breast and lung recur. rence → Palliative therapy → Progression on. lung, left breast.. Primary Treatment. See Figs. 31, 32, and 33.. Operation. Dec. 2020 Left breast conserving surgery, senti. nel lymph node biopsy.. Path... |
44 | Case 10 | Patient History | Metastatic Breast Cancer | Patient History and Progress. Female/53 years old, post-menopause.. No family history.. S/p cholecystectomy, s/p knee giant cell tumor. excision, s/p interstitial mammoplasty.. S/p otitis media operation.. 10.2. |
45 | Case 11 | Courses of Treatment | Benign and Proliferative | 11.1. . Courses of Treatment. →2021-10-29 excision, Rt.. Benign and Proliferative Case Series. 30. . . . . Pathology Report. Diagnosis. • Breast, right, excision:. –. – Intraductal papilloma.. 12. |
53 | Case 11 | Important Radiologic | Benign and Proliferative | Important Radiologic. Findings. 18. 11.3. |
59 | Case 11 | Patient History | Benign and Proliferative | Patient History and Progress. Female/39 years old, pre-menopause.. Serous discharge from right nipple.. No family history.. Asthma, hyperthyroidism.. 11.2. |
46 | Case 11 | Courses of Treatment | Carcinoma In Situ | 11.1. . Courses of Treatment:. Operation. Operation. . 50. 51. Pathology Report. <First operation>. . 1. Ductal Carcinoma In Situ, Pathological TN. Category (AJCC 2017): pTis. . (a) Size of tumor: 0.3 cm (pTis).. . (b) Nuclear grade: low.. . (c) Necrosis: absent.. . (d) Architectural pattern: micropapillary/. cr... |
54 | Case 11 | Important Radiologic | Carcinoma In Situ | Important Radiologic. Findings. 49. 11.3. |
60 | Case 11 | Patient History | Carcinoma In Situ | Patient History and Progress. Female/44 years old, pre-menopause.. Screen detected mass lesion on right breast 8. o’clock direction.. Outside result of biopsy:. Right breast, 8 o’clock, (1) adenosis, (2) fibro. cystic change, (3) flat epithelial atypia.. Family history, Father: Prostate cancer.. S/P Percutaneous closu... |
47 | Case 11 | Courses of Treatment | HR(+) HER2(+) Breast Cancer | 11.1. . Courses of Treatment. Operation + Adjuvant chemotherapy (#4. cycles of doxorubicin and cyclophospha. mide). +. Post-operative. radiation. ther. apy + Trastuzumab + Letrozole 2.5 mg/day.. 63. Pathology Report. . 1. Invasive Ductal Carcinoma.. . (a) Size of tumor: 1.1 cm (pT1c).. . (b) Histologic grade: 2... |
55 | Case 11 | Important Radiologic | HR(+) HER2(+) Breast Cancer | Important Radiologic. Findings. 59 60 61. 62. HR(+) HER2(+) Breast Cancer. 334. . . 11.3. |
61 | Case 11 | Patient History | HR(+) HER2(+) Breast Cancer | Patient History and Progress. Female/60 years old, post-menopause.. Screen detected microcalcification on upper. outer portion of right breast.. No family history.. Hypertension.. 11.2. |
48 | Case 11 | Courses of Treatment | HR(+) HER2(-) Breast Cancer | Courses of Treatment. Operation. +. Adjuvant. chemotherapy. (#4 cycles of docetaxel & cyclophospha. mide). +. Post-operative. radiation. ther. apy + Letrozole 2.5 mg/day.. Operation. Left breast conserving surgery, sentinel lymph. 5. Surgical margins:. . (a) superior margin: 5 mm,. . (b) inferior margin: 15 mm,. ... |
56 | Case 11 | Important Radiologic | HR(+) HER2(-) Breast Cancer | Important Radiologic. Findings. See Figs. 53, 54, 55 and 56.. 11.3. |
62 | Case 11 | Patient History | HR(+) HER2(-) Breast Cancer | Dyslipidemia.. 11.2. |
49 | Case 11 | Courses of Treatment | HR(−) HER2(+) Breast Cancer | 11.1. . operative radiation therapy + Trastuzumab.. Operation. 86. Pathology Report. Invasive Ductal Carcinoma. 1. Post-chemotherapy status.. 2. Size of tumor: 1.5 cm (ypT1c).. 3. Histologic grade: 3/3 (tubule formation: 3/3,. nuclear pleomorphism: 3/3, mitotic count:. 3/3, 5/HPF).. 4. Intraductal component: prese... |
57 | Case 11 | Important Radiologic | HR(−) HER2(+) Breast Cancer | Important Radiologic. Findings. 78 79 80. 81. . . HR(−) HER2(+) Breast Cancer. 470. . After Neoadjuvant. Chemotherapy. 82 83 84. 85. . . Y. Kwon et al. |
63 | Case 11 | Patient History | HR(−) HER2(+) Breast Cancer | Patient History and Progress. Female/56 years old, post-menopause.. Self-detected palpable mass lesion on right. breast.. No family history.. Diabetes mellitus, hepatitis C virus carrier.. 11.2. |
50 | Case 11 | Courses of Treatment | HR(−) HER2(−) Breast Cancer | 11.1. . Courses of Treatment. Neoadjuvant chemotherapy (#4 cycles of doxo. rubicin and cyclophosphamide + #4 cycles of. docetaxel) + Operation + Post-operative radia. tion therapy + Adjuvant capecitabine.. Operation. 82. Pathology Report. Invasive Ductal Carcinoma. 1. Post-chemotherapy status.. 2. Size of tumor: 0... |
58 | Case 11 | Important Radiologic | HR(−) HER2(−) Breast Cancer | Important Radiologic. Findings. 74 75 76. 77. E. S. Lee et al.. 613. . . . HR(−) HER2(−) Breast Cancer. 614. . After Neoadjuvant. Chemotherapy. 78 79 80. 81. 11.3. |
64 | Case 11 | Patient History | HR(−) HER2(−) Breast Cancer | Patient History and Progress. Female/50 years old, pre-menopause.. Screen detected mass lesion on upper outer. portion of right breast.. Family history of breast cancer, mother and. aunt (paternal).. No comorbidities.. BRCA 1 and 2 mutation: Not detected.. 11.2. |
51 | Case 11 | Courses of Treatment | Local Recurrence | 11.1. . Courses of Treatment. Right breast IDC → Operation → Adjuvant. therapy → Right breast recurrence (IDC).. Primary Treatment. Operation. Nov. 2008 Right breast conserving surgery, senti. nel lymph node biopsy (outside).. Pathology Report. Invasive Ductal Carcinoma. . 1. Size of tumor: 1.3 cm (pT1c).. . 2. Lym... |
65 | Case 11 | Patient History | Local Recurrence | Patient History and Progress. Female/45 years old, post-menopause.. Screen detected mass lesion on right breast 10. o’clock direction.. No family history.. S/P bilateral salpingo-oophorectomy (right. ovary borderline tumor).. BRCA 1 and 2 mutation: Not detected.. 11.2. |
52 | Case 11 | Courses of Treatment | Metastatic Breast Cancer | Courses of Treatment. Both breasts cancer → Operation → Adjuvant. therapy → Right axillary lymph node. Intensity. Positive %. Estrogen. receptor. Strong (8/8). 3. >2/3. Progesterone. receptor. Weak (3/8). 2. <1%. C-erbB2. Equivocal. (2+). Result. Intensity. Positive %. Ki-67. Positive in. 22% of. tumor cells. SISH. Equ... |
66 | Case 12 | Courses of Treatment | Benign and Proliferative | 12.1. . Courses of Treatment. →2021-10-29 excision, Lt.. Pathology Report. Diagnosis. • Breast, left, excision:. –. – Intraductal papilloma (#1. 2 o’clock, #2.. 5 o’clock & #3. 9 o’clock) with (1) usual. ductal hyperplasia, (2) apocrine metaplasia.. C. W. Lee et al.. 31. 13. |
74 | Case 12 | Important Radiologic | Benign and Proliferative | Important Radiologic. Findings. 19. 20. 12.3. |
80 | Case 12 | Patient History | Benign and Proliferative | Patient History and Progress. Female/70 years old, post-menopause.. Screen detected mass lesion on left breast. 2 o’clock and 5 o’clock and 9 o’clock direction.. No family history.. s/p Right breast conserving surgery (right. breast cancer), hypertension, diabetes mellitus.. 12.2. |
67 | Case 12 | Courses of Treatment | Carcinoma In Situ | 12.1. . Courses of Treatment. Operation + Tamoxifen 20 mg/day for 5 years.. Operation. . . 55. 56. Pathology Report. Ductal carcinoma in situ, pathological TN cat. egory (AJCC 2017): pTisN0(sn). . 1. Size of tumor: 1.0 cm (pTis).. . 2. Nuclear grade: high.. . 3. Necrosis: present.. . 4. Architectural. pattern:.... |
75 | Case 12 | Important Radiologic | Carcinoma In Situ | Important Radiologic. Findings. 52 53. 54. 12.3. |
81 | Case 12 | Patient History | Carcinoma In Situ | Patient History and Progress. Female/49 years old, pre-menopause.. Screen detected mass lesion on right breast. 4:30 and 9 o’clock direction.. Outside result of biopsy:. Left breast 4: 30 o’clock, ductal carcinoma in. situ.. Left breast 9 o’clock, intraductal papilloma.. Family history of breast cancer, sister at her. ... |
68 | Case 12 | Courses of Treatment | HR(+) HER2(+) Breast Cancer | 12.1. . Courses of Treatment. Neoadjuvant chemotherapy (#1 cycle of. docetaxel and carboplatin and trastuzumab. and pertuzumab followed by #5 cycles of. docetaxel and carboplatin) + Operation +. Adjuvant chemotherapy (doxorubicin and. cyclophosphamide) + Post-. operative radiation. therapy + Letrozole 2.5 mg/day..... |
76 | Case 12 | Important Radiologic | HR(+) HER2(+) Breast Cancer | Important Radiologic. Findings. 64 65 66 67. 68. S. Park et al.. 337. . . 12.3. |
82 | Case 12 | Patient History | HR(+) HER2(+) Breast Cancer | Patient History and Progress. Female/63 years old, post-menopause.. Screen detected mass lesion on left breast 10. o’clock direction.. No family history.. s/p Idiopathic thrombocytopenic purpura. (2020).. 12.2. |
69 | Case 12 | Courses of Treatment | HR(+) HER2(-) Breast Cancer | Courses of Treatment. Operation. +. Adjuvant. chemotherapy. (#4 cycles of docetaxel & cyclophospha. mide). +. Post-operative. radiation. ther. apy + Tamoxifen 20 mg/day.. Operation. Right breast conserving surgery, sentinel lymph. extratumoral (30%) (nuclear grade: low,. necrosis: present, architectural pattern: sol... |
77 | Case 12 | Important Radiologic | HR(+) HER2(-) Breast Cancer | Important Radiologic. Findings. See Figs. 58, 59, 60 and 61.. 12.3. |
83 | Case 12 | Patient History | HR(+) HER2(-) Breast Cancer | S/P hysterectomy, dyslipidemia, diabetes mel. litus, s/p cervical spine disc operation.. 12.2. |
70 | Case 12 | Courses of Treatment | HR(−) HER2(+) Breast Cancer | 12.1. . Invasive Ductal Carcinoma with medullary. pattern. 1. Size of tumor: 2.9 cm (pT2).. 2. Histologic grade: 3/3 (tubule formation: 3/3,. nuclear pleomorphism: 3/3, mitotic count:. 3/3, 5/HPF).. 3. Intraductal component: present, intratu. moral/extratumoral (30%) (nuclear grade:. high, necrosis: present, archi... |
78 | Case 12 | Important Radiologic | HR(−) HER2(+) Breast Cancer | Important Radiologic. Findings. 87 88 89 |
84 | Case 12 | Patient History | HR(−) HER2(+) Breast Cancer | Patient History and Progress. Female/66 years old, post-menopause.. Self-detected palpable mass lesion on left. breast.. No family history.. Hypertension, thyroidectomy (hyperthyroid. ism), s/p salpingectomy.. 12.2. |
71 | Case 12 | Courses of Treatment | HR(−) HER2(−) Breast Cancer | 12.1. . Courses of Treatment. Neoadjuvant chemotherapy (#4 cycles of doxo. rubicin and cyclophosphamide + #4 cycles of. docetaxel) + Operation + Adjuvant capecitabine.. Operation. . . . 89. 90. Pathology Report. Invasive Ductal Carcinoma. 1. Post-chemotherapy status.. 2. Size of tumor: 0.5 cm (ypT1a).. 3. His... |
79 | Case 12 | Important Radiologic | HR(−) HER2(−) Breast Cancer | Important Radiologic. Findings. 83 84. 85. . . . HR(−) HER2(−) Breast Cancer. 618. . . . . After Neoadjuvant. Chemotherapy. 86 87. 88. 12.3. |
85 | Case 12 | Patient History | HR(−) HER2(−) Breast Cancer | Patient History and Progress. Female/47 years old, post-menopause.. Screen detected a mass lesion on right breast. 10 o’clock direction.. Family history of breast cancer, aunt (mater. nal) and cousin.. Family history of ovarian cancer, aunt.. Lupus (follow-up), s/p bilateral salpingo-. oophorectomy, s/p unilateral th... |
72 | Case 12 | Courses of Treatment | Local Recurrence | 12.1. . Courses of Treatment. Right breast DCIS → Operation → Right breast. recurrence (microinvasive ductal carcinoma).. Primary Treatment. 89 90. 91. Operation. . 92. Pathology Report. Ductal carcinoma in situ. . 1. Size of tumor: 2.3 cm (pTis).. . 2. Nuclear grade: low.. . 3. Necrosis: absent.. . 4. Architectu... |
86 | Case 12 | Patient History | Local Recurrence | Patient History and Progress. Female/55 years old, peri-menopause.. Screen detected mass lesion on right breast 9. o’clock direction.. Family history of prostate cancer, father.. s/p hysterectomy, HPV infection.. 12.2. |
73 | Case 12 | Courses of Treatment | Metastatic Breast Cancer | 12.1. . Courses of Treatment. Left breast cancer → Operation → Adjuvant. therapy → Ipsilateral axillary lymph node. recurrence → Contralateral breast cancer.. Primary Treatment. receptor. Strong (8/8). 3. >2/3. Progesterone. receptor. Intermediate. (6/8). 2. 1/3–2/3. C-erbB2. Equivocal (2+). Ki-67. Positive in 26%. of... |
87 | Case 12 | Patient History | Metastatic Breast Cancer | Patient History and Progress. Female/78 years old, post-menopause.. No family history.. Hypertension, diabetes mellitus.. 12.2. |
88 | Case 13 | Courses of Treatment | Benign and Proliferative | 13.1. . Courses of Treatment. →2021-10-26 excision, Rt.. . Benign and Proliferative Case Series. 32. . Pathology Report. • Breast, right 12 o’clock, excision:. –. – Flat. epithelial. atypia. with. microcalcification. • Breast, right 2 o’clock, excision:. –. – Atypical. ductal. hyperplasia. with. microcalcification..... |
96 | Case 13 | Important Radiologic | Benign and Proliferative | Important Radiologic. Findings. 21. 22. 13.3. |
102 | Case 13 | Patient History | Benign and Proliferative | Patient History and Progress. Female/45 years old, pre-menopause.. Screen detected microcalcification on upper. center of right breast.. No family history.. No comorbidities.. 13.2. |
89 | Case 13 | Courses of Treatment | Carcinoma In Situ | . Courses of Treatment. Operation + Tamoxifen 20 mg/day for 5 years.. Operation. 58. 59. Pathology Report. <First operation>. Ductal carcinoma in situ, pathological TN cat. egory (AJCC 2017): pTis. . 1. Size of tumor: 0.5 cm (pTis).. . 2. Nuclear grade: low.. . 3. Necrosis: absent.. . 4. Architectural pattern: pa... |
97 | Case 13 | Important Radiologic | Carcinoma In Situ | Important Radiologic. Findings. 57. 13.3. |
103 | Case 13 | Patient History | Carcinoma In Situ | Patient History and Progress. Female/61 years old, post-menopause.. Screen detected mass lesion on left breast. 10 o’clock direction.. Outside result of biopsy: Left breast. 10 o’clock, papillary neoplasm.. Family history of breast cancer, sister.. No comorbidities.. BRCA 1 and 2: Not check.. 13.2. |
90 | Case 13 | Courses of Treatment | HR(+) HER2(+) Breast Cancer | 13.1. . Courses of Treatment. Operation + Adjuvant chemotherapy (#4. cycles. of. docetaxel. and. cyclophospha. mide). +. Post-operative. radiation. ther. apy + Trastuzumab + Letrozole 2.5 mg/day.. 73. Pathology Report. Invasive Ductal Carcinoma. 1. Size of tumor: 2.1 cm (pT2).. 2. Histologic grade: 2/3 (tubule f... |
98 | Case 13 | Important Radiologic | HR(+) HER2(+) Breast Cancer | Important Radiologic. Findings. 70 71. 72. 13.3. |
104 | Case 13 | Patient History | HR(+) HER2(+) Breast Cancer | Patient History and Progress. Female/53 years old, post-menopause.. Screen detected mass lesion on left breast 1:30. o’clock direction.. No family history.. Hypertension, arrhythmia, s/p myomectomy.. 13.2. |
91 | Case 13 | Courses of Treatment | HR(+) HER2(-) Breast Cancer | Courses of Treatment. Operation. +. Adjuvant. chemotherapy. (#4 cycles of doxorubicin & cyclophosphamide. followed by #4 cycles of docetaxel) + Post-. operative radiation therapy + Letrozole. 2.5 mg/day.. Operation. sive intraductal component: absent).. 4. Skin and nipple: dermal involvement of. tumor.. 5. Surg... |
99 | Case 13 | Important Radiologic | HR(+) HER2(-) Breast Cancer | Important Radiologic. Findings. See Figs. 63, 64, 65 and 66.. 13.3. |
105 | Case 13 | Patient History | HR(+) HER2(-) Breast Cancer | S/P Tuberculosis, S/P appendectomy.. 13.2. |
92 | Case 13 | Courses of Treatment | HR(−) HER2(+) Breast Cancer | 13.1. . Courses of Treatment. Neoadjuvant chemotherapy (#6 cycles of. docetaxel and carboplatin and trastuzumab and. pertuzumab) + Operation + Post-operative radia. 2. Size of tumor: 0.3 cm (ypT1a).. 3. Histologic grade: 3/3 (tubule formation: 3/3,. nuclear pleomorphism: 3/3, mitotic count:. 3/3, 4/HPF).. 4. Intra... |
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