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100 | Case 13 | Important Radiologic | HR(−) HER2(+) Breast Cancer | Important Radiologic. Findings. 92 93. 94. . Y. Kwon et al.. 479. 95 96 97. 98. 13.4. |
106 | Case 13 | Patient History | HR(−) HER2(+) Breast Cancer | Patient History and Progress. Female/44 years old, pre-menopause.. Self-detected palpable mass lesion on left. breast 11 o’clock direction.. No family history.. No comorbidities.. 13.2. |
93 | Case 13 | Courses of Treatment | HR(−) HER2(−) Breast Cancer | 13.1. . Courses of Treatment. Neoadjuvant chemotherapy (#4 cycles of. doxorubicin and cyclophosphamide + #4. cycles of docetaxel) + Operation + Post-. operative radiation therapy + Adjuvant. capecitabine.. Operation. 98. Pathology Report. Invasive Ductal Carcinoma. 1. Post-chemotherapy status.. 2. Size of t... |
101 | Case 13 | Important Radiologic | HR(−) HER2(−) Breast Cancer | Important Radiologic. Findings. 91 92. 93. After Neoadjuvant. Chemotherapy. 94 95 96. 97. 13.3. |
107 | Case 13 | Patient History | HR(−) HER2(−) Breast Cancer | Patient History and Progress. Female/67 years old, post-menopause.. Self-detected mass lesion on left breast.. No family history.. Hepatitis C virus carrier, arrhythmia.. 13.2. |
94 | Case 13 | Courses of Treatment | Local Recurrence | 13.1. . Courses of Treatment. Right breast microinvasive ductal carcinoma →. Operation → Right breast recurrence (DCIS).. Primary Treatment. 96 97. 98. . . . Local Recurrence. 754. a. b. . a. b. . Operation. . 99. 100. Pathology Report. Microinvasive Ductal Carcinoma. 1. Size of invasive component: <0.1 cm. (pT1mi)... |
108 | Case 13 | Patient History | Local Recurrence | Patient History and Progress. Female/42 years old, pre-menopause.. Screen detected mass lesion on right breast 3. o’clock direction and bloody discharge from. right nipple.. Outside result of biopsy: Ductal carcinoma in. situ.. No family history.. No comorbidities.. BRCA 1 and 2 mutation: not detected.. 13.2. |
95 | Case 13 | Courses of Treatment | Metastatic Breast Cancer | 13.1. . Courses of Treatment. Right breast cancer → Operation → Adjuvant. therapy → Ipsilateral axillary lymph node. recurrence.. Primary Treatment. Estrogen. receptor. Intermediate. (6/8). 1. >2/3. Progesterone. receptor. Strong (8/8). 3. >2/3. C-erbB2. Negative (0). Ki-67. Positive in. 18% of tumor. cells. Adjuvant ... |
109 | Case 13 | Patient History | Metastatic Breast Cancer | Patient History and Progress. Female/39 years old, post-menopause.. Family history of ovarian cancer, paternal. aunt.. BRCA. 1. mutation: VUS. (variant. of. uncertain).. S/p bilateral salpingo-oophorectomy.. 13.2. |
110 | Case 14 | Courses of Treatment | Benign and Proliferative | 14.1. . Courses of Treatment. →2021-10-15 excision, Rt.. Pathology Report. • Breast, right, excision:. –. – Atypical ductal hyperplasia involving. intraductal papilloma with marked cautery. artifact.. C. W. Lee et al.. 33. . . 15. |
118 | Case 14 | Important Radiologic | Benign and Proliferative | Important Radiologic. Findings. 23. 24. 14.3. |
124 | Case 14 | Patient History | Benign and Proliferative | Patient History and Progress. Female/60 years old, post-menopause.. Screen detected mass lesion on right breast. 9 o’clock direction.. Family history of breast cancer, mother.. s/p Total hysterectomy (leiomyoma) and Left. salpingo-oophorectomy.. 14.2. |
111 | Case 14 | Courses of Treatment | Carcinoma In Situ | 14.1. . Courses of Treatment:. Operation. Operation. 61. 62. Pathology Report. <First operation>. Ductal carcinoma in situ, pathological TN cat. egory (AJCC 2017): pTis. . 1. Size of tumor: 0.3 cm (pTis).. . 2. Nuclear grade: low.. . 3. Necrosis: absent.. . 4. Architectural pattern: papillary.. . 5. Surgical mar... |
119 | Case 14 | Important Radiologic | Carcinoma In Situ | Important Radiologic. Findings. 60. 14.3. |
125 | Case 14 | Patient History | Carcinoma In Situ | Patient History and Progress. Female/54 years old, pre-menopause.. Screen detected microcalcification on upper. inner portion of left.. No family history.. Taking medication for bladder dysfunction.. 14.2. |
112 | Case 14 | Courses of Treatment | HR(+) HER2(+) Breast Cancer | 14.1. . Courses of Treatment. Operation + Adjuvant chemotherapy (#4. cycles of doxorubicin and cyclophosphamide. followed by #4 cycles of docetaxel and trastu. zumab) + Post-operative radiation ther. apy + Trastuzumab + Tamoxifen 20 mg/day.. 77. Pathology Report. Invasive Ductal Carcinoma. 1. Size of tumor: 1.5... |
120 | Case 14 | Important Radiologic | HR(+) HER2(+) Breast Cancer | Important Radiologic. Findings. 74 75. 76. 14.3. |
126 | Case 14 | Patient History | HR(+) HER2(+) Breast Cancer | Patient History and Progress. Female/51 years old, peri-menopause.. Screen detected mass lesion on portion of. lower of right breast.. Family history of breast cancer, sister.. Hypothyroidism (taking on synthroid).. BRCA 1 and 2 mutation: Not detected.. 14.2. |
113 | Case 14 | Courses of Treatment | HR(+) HER2(-) Breast Cancer | 14.1. . Courses of Treatment. Neoadjuvant therapy (Palbociclib 125 mg/day. &. tamoxifen. 20. mg/day. with. gosere. lin) + Operation + Post-operative radiation. therapy. +. Letrozole. 2.5. mg/day. with. goserelin.. Operation. Left breast conserving surgery, sentinel lymph. . (a) superior margin: 5 mm.. . (b) inf... |
121 | Case 14 | Important Radiologic | HR(+) HER2(-) Breast Cancer | Important Radiologic. Findings. See Figs. 68, 69, 70, 71 and 72.. 14.3. |
127 | Case 14 | Patient History | HR(+) HER2(-) Breast Cancer | Patient History and Progress. Female/43 years old, pre-menopause.. Screen detected mass lesion on left breast 1. and 3 o’clock direction.. No family history.. No comorbidities.. 14.2. |
114 | Case 14 | Courses of Treatment | HR(−) HER2(+) Breast Cancer | 14.1. . Courses of Treatment. Neoadjuvant chemotherapy (#3 cycles of. docetaxel and trastuzumab and pertuzumab after. followed #3 cycles of trastuzumab and pertu. zumab #4) + Operation + Post-operative radia. tion therapy + Trastuzumab emtansine.. Operation. Microinvasive Ductal Carcinoma. 1. Size of invasive compo... |
122 | Case 14 | Important Radiologic | HR(−) HER2(+) Breast Cancer | Important Radiologic. Findings. 100 101 102. 103. . HR(−) HER2(+) Breast Cancer. After Neoadjuvant. Chemotherapy. 104 105 106. 107. HR(−) HER2(+) Breast Cancer. 486. 14.4. |
128 | Case 14 | Patient History | HR(−) HER2(+) Breast Cancer | Patient History and Progress. Female/74 years old, post-menopause.. Screen detected mass lesion on right breast 12. o’clock direction.. No family history.. S/P retroperitoneum, excision (paragang. lioma).. 14.2. |
115 | Case 14 | Courses of Treatment | HR(−) HER2(−) Breast Cancer | 14.1. . Courses of Treatment. Operation + Adjuvant chemotherapy (#4. cycles of doxorubicin and cyclophosphamide. + #12 cycles of paclitaxel) + Post-. operative. radiation therapy.. Operation. 103. Pathology Report. Invasive Ductal Carcinoma. 1. Size of tumor: 3.0 cm (pT2).. 2. Histologic grade: 3/3 (tubule form... |
123 | Case 14 | Important Radiologic | HR(−) HER2(−) Breast Cancer | Important Radiologic. Findings. 99 100 101. 102. 14.3. |
129 | Case 14 | Patient History | HR(−) HER2(−) Breast Cancer | Patient History and Progress. Female/43 years old, pre-menopause.. Self-detected palpable mass lesion on right. breast.. Family history of breast cancer, grandmother.. s/p Right breast, mammotome excision, s/p. right ear, benign excision.. BRCA 1 and 2 mutation: Not detected.. 14.2. |
116 | Case 14 | Courses of Treatment | Local Recurrence | 14.1. . Courses of Treatment. Right breast infiltrating ductal carcinoma →. Operation → Left breast recurrence (IDC).. Primary Treatment. 103. 104. Operation. Aug. 2003 Right breast conserving surgery, axil. lary lymph node dissection, left breast mass. excision.. Pathology Report. <Right>. Infiltrating Ductal Carcin... |
130 | Case 14 | Patient History | Local Recurrence | Patient History and Progress. Female/72 years old, post-menopause.. Screen detected mass lesion on right breast 1. o’clock direction and left 9 o’clock direction.. No family history.. Diabetes mellitus.. BRCA 1 and 2 mutation: Not detected, ATM. and POLE VUS (variant of uncertain).. . . . Local Recurrence. 756. 14.2. ... |
117 | Case 14 | Courses of Treatment | Metastatic Breast Cancer | Courses of Treatment. Right breast cancer → Operation → Adjuvant. therapy → Ipsilateral axillary lymph node. recurrence.. Primary Treatment. Estrogen. receptor. Intermediate. (6/8). 2. 1/3–2/3. Progesterone. receptor. Strong (7/8). 2. >2/3. C-erbB2. Negative (0). Ki-67. Positive in. 35% of tumor. cells. Adjuvant Therap... |
131 | Case 14 | Patient History | Metastatic Breast Cancer | Hepatitis B carrier.. 14.2. |
132 | Case 15 | Courses of Treatment | Benign and Proliferative | 15.1. . Courses of Treatment. →2021-10-12 excision, Lt.. Benign and Proliferative Case Series. 34. . . Pathology Report. • Breast, left, excision:. –. – Atypical ductal hyperplasia, focal. –. – Fibroadenomatous change.. 16. |
140 | Case 15 | Important Radiologic | Benign and Proliferative | Important Radiologic. Findings. 25. 26. 15.3. |
146 | Case 15 | Patient History | Benign and Proliferative | Patient History and Progress. Female/33 years old, pre-menopause.. Screen detected mass lesion on left breast. 3 o’clock direction.. Family history of pancreatic cancer, maternal. grandmother.. No comorbidities.. BRCA 1 and 2 mutation: Not detected.. 15.2. |
133 | Case 15 | Courses of Treatment | Carcinoma In Situ | 15.1. . Courses of Treatment. Operation + Postoperative radiation therapy +. Tamoxifen 20 mg/day for 5 years.. Operation. 67. 68. E. S. Lee et al.. 83. 2. Nuclear grade: high.. 3. Necrosis: present.. 4. Architectural pattern: micropapillary/cribri. form/solid/comedo.. 5. Skin: no involvement of tumor.. 6. Surgic... |
141 | Case 15 | Important Radiologic | Carcinoma In Situ | Important Radiologic. Findings. 63 64 65. 66. 15.3. |
147 | Case 15 | Patient History | Carcinoma In Situ | Patient History and Progress. Female/52 years old, pre-menopause.. Screen detected mass lesion on right breast. 1 o’clock direction.. No family history.. No comorbidities.. 15.2. |
134 | Case 15 | Courses of Treatment | HR(+) HER2(+) Breast Cancer | 15.1. . Courses of Treatment. Operation + Adjuvant chemotherapy (#4. cycles of doxorubicin and cyclophospha. mide). +. Post-operative. radiation. ther. apy + Trastuzumab + Tamoxifen 20 mg/day.. 82. . . . . HR(+) HER2(+) Breast Cancer. 346. . . Pathology Report. . 1. Invasive Ductal Carcinoma with apocrine. diff... |
142 | Case 15 | Important Radiologic | HR(+) HER2(+) Breast Cancer | Important Radiologic. Findings. 78 79 80. 81. 15.3. |
148 | Case 15 | Patient History | HR(+) HER2(+) Breast Cancer | Patient History and Progress. Female/42 years old, pre-menopause.. Self-detected palpable mass lesion on right. breast 6 o’clock direction.. Family history of breast cancer, maternal aunt.. No comorbidities.. BRCA 1 and 2 mutation: Not detected.. 15.2. |
135 | Case 15 | Courses of Treatment | HR(+) HER2(-) Breast Cancer | 15.1. . Courses of Treatment. Operation + Post-operative radiation ther. apy + Anastrozole 1 mg/day.. Operation. Left breast conserving surgery, sentinel lymph. (a) superior margin: 35 mm.. . (b) inferior margin: 10 mm.. . (c) medial margin: 15 mm.. . (d) lateral margin: 5 mm.. . (e) deep margin: 12 mm.. . (f)... |
143 | Case 15 | Important Radiologic | HR(+) HER2(-) Breast Cancer | Important Radiologic. Findings. See Figs. 74, 75, 76 and 77.. 15.3. |
149 | Case 15 | Patient History | HR(+) HER2(-) Breast Cancer | Patient History and Progress. Female/58 years old, post-menopause.. Screen detected mass lesion on left breast 12. o’clock direction.. No family history.. Hypertension, dyslipidemia, s/p transobtura. tor tape for stress urinary incontinence.. 15.2. |
136 | Case 15 | Courses of Treatment | HR(−) HER2(+) Breast Cancer | 15.1. . 116. Pathology Report. Invasive Ductal Carcinoma. 1. Post-chemotherapy status.. 2. Size of tumor: 1.9 cm (ypT1c).. 3. Histologic grade: 3/3 (tubule formation: 3/3,. nuclear pleomorphism: 3/3, mitotic count:. 2/3, 12/10HPF).. 4. Intraductal component: absent.. 5. Skin: no involvement of tumor.. 6. Surgica... |
144 | Case 15 | Important Radiologic | HR(−) HER2(+) Breast Cancer | Important Radiologic. Findings. 109 110 111. . After Neoadjuvant. Chemotherapy. 113 114. 115. . HR(−) HER2(+) Breast Cancer. 492 |
150 | Case 15 | Patient History | HR(−) HER2(+) Breast Cancer | Patient History and Progress. Female/61 years old, post-menopause.. Self-detected palpable mass lesion on right. breast 12 o’clock direction.. No family history.. Hypertension.. HR(−) HER2(+) Breast Cancer. 488. . Y. Kwon et al.. 489. 15.2. |
137 | Case 15 | Courses of Treatment | HR(−) HER2(−) Breast Cancer | 15.1. . Courses of Treatment. Operation + operation.. Operation. . 107. Pathology Report. . 1. Invasive Ductal Carcinoma.. . (a) Size of invasive component: 0.4 cm. (pT1a).. . (b) Size of intraductal component: 4.0 cm.. . (c) Histologic grade: 3/3 (tubule formation:. 3/3, nuclear pleomorphism: 3/3, mitotic. coun... |
145 | Case 15 | Important Radiologic | HR(−) HER2(−) Breast Cancer | Important Radiologic. Findings. 104 105. 106. 15.3. |
151 | Case 15 | Patient History | HR(−) HER2(−) Breast Cancer | Patient History and Progress. Female/74 years old, post-menopause.. Self-detected bloody discharge on the nipple. of the left breast.. No family history.. S/P hysterectomy (due to myoma), hyperten. sion, s/p shoulder calcific tendinitis operation.. 15.2. |
138 | Case 15 | Courses of Treatment | Local Recurrence | 15.1. . Courses of Treatment. Right breast IDC → Operation → Adjuvant. therapy →Left breast and axillary lymph node. recurrence (IDC) → Left axillary lymph node. recurrence.. Primary Treatment. 109. 110. Operation. 111. Pathology Report. Invasive Ductal Carcinomas (×2).. 1. Size of tumor: 2.1 cm, 0.7 cm (pT2(m)).. 2.... |
152 | Case 15 | Patient History | Local Recurrence | Patient History and Progress. Female/63 years old, post-menopause.. Self-detected mass lesion on right breast 9. o’clock direction.. Family history of breast cancer, mother.. Hypertension, s/p Left leg fracture operation.. BRCA 1 and 2 mutation: Not detected.. 15.2. |
139 | Case 15 | Courses of Treatment | Metastatic Breast Cancer | 15.1. . Courses of Treatment. Right breast cancer → Operation → Adjuvant. therapy → Ipsilateral axillary lymph node. recurrence.. Primary Treatment. receptor. Strong (8/8). 3. >2/3. Progesterone. receptor. Strong (8/8). 3. >2/3. C-erbB2. Negative (1+). Ki-67. Positive in. 31% of tumor. cells. Adjuvant Therapy. Tamoxif... |
153 | Case 15 | Patient History | Metastatic Breast Cancer | Patient History and Progress. Female/74 years old, post-menopause.. No family history.. Hypertension.. 15.2. |
154 | Case 16 | Courses of Treatment | Benign and Proliferative | 16.1. . Courses of Treatment. →2021-09-13 needle biopsy.. Pathology Report. Diagnosis. • Breast, right, needle biopsy:. –. – Ductal carcinoma in situ.. Nuclear grade: low.. Necrosis: present.. C. W. Lee et al.. 35. . . . Benign and Proliferative Case Series. 36. . Architectural pattern: micropapillary/. cribriform/c... |
162 | Case 16 | Important Radiologic | Benign and Proliferative | Important Radiologic. Findings. 27 28. 29. 16.3. |
168 | Case 16 | Patient History | Benign and Proliferative | Patient History and Progress. Female/59 years old, post-menopause.. Screen detected mass lesion on right breast. 7 o’clock direction.. No family history.. s/p Total hysterectomy, s/p left nephrectomy. (donor), s/o cholecystectomy.. 16.2. |
155 | Case 16 | Courses of Treatment | Carcinoma In Situ | 16.1. . Courses of Treatment:. Operation. Operation. 73. 74. Pathology Report. Ductal carcinoma in situ, pathological TN cat. egory (AJCC 2017): pTis(Paget)N0 (sn). . 1. Size of tumor: 1.5 cm (pTis(Paget)).. . 2. Nuclear grade: high.. . 3. Necrosis: present.. Carcinoma In Situ. 4. Architectural. pattern:. cribrif... |
163 | Case 16 | Important Radiologic | Carcinoma In Situ | Important Radiologic. Findings. 69 70 71. 72. E. S. Lee et al.. 85. . . . . 16.3. |
169 | Case 16 | Patient History | Carcinoma In Situ | Patient History and Progress. Female/75 years old, post-menopause.. Screen detected microcalcification on left. breast 12 o’clock direction.. Outside result of biopsy: Left breast 12 o’clock,. fibrosis.. Family history of breast cancer, mother.. Hypertension.. BRCA 1 and 2: Not examination.. 16.2. |
156 | Case 16 | Courses of Treatment | HR(+) HER2(+) Breast Cancer | 16.1. . Courses of Treatment. Operation + Adjuvant chemotherapy (#4. cycles. of. docetaxel. and. cyclophospha. mide). +. Post-operative. radiation. ther. apy + Trastuzumab + Letrozole 2.5 mg/day.. 87. Pathology Report. . 1. Invasive Ductal Carcinoma.. . (a) Size of tumor: 1.1 cm (pT1c).. . (b) Histologic grade:... |
164 | Case 16 | Important Radiologic | HR(+) HER2(+) Breast Cancer | Important Radiologic. Findings. 83 84 85. 86. 16.3. |
170 | Case 16 | Patient History | HR(+) HER2(+) Breast Cancer | Patient History and Progress. Female/54 years old, peri-menopause.. Self-detected palpable mass lesion on right. breast 6 o’clock direction.. No family history.. Diabetes. mellitus,. S/P. hysterectomy,. agoraphobia.. 16.2. |
157 | Case 16 | Courses of Treatment | HR(+) HER2(-) Breast Cancer | 16.1. . Courses of Treatment. Operation + Post-operative radiation ther. apy + Tamoxifen 20 mg/day.. Operation. Left breast conserving surgery, sentinel lymph. cribriform/solid, extensive intraductal com. ponent: present).. 5. Skin: no involvement of tumor.. 6. Surgical margins:. . (a) superior margin: 20 mm.. ... |
165 | Case 16 | Important Radiologic | HR(+) HER2(-) Breast Cancer | Important Radiologic. Findings. See Figs. 79, 80, 81 and 82.. 16.3. |
171 | Case 16 | Patient History | HR(+) HER2(-) Breast Cancer | Patient History and Progress. Female/51 years old, peri-menopause.. Screen detected mass lesion on left breast 2. o’clock direction.. No family history.. No comorbidities.. 16.2. |
158 | Case 16 | Courses of Treatment | HR(−) HER2(+) Breast Cancer | 16.1. . Courses of Treatment. Operation + adjuvant chemotherapy (#4 cycles of. docetaxel and cyclophosphamide) + Post-. operative radiation therapy + Trastuzumab.. Operation. 121. Pathology Report. Invasive Ductal Carcinoma. 1. Size of tumor: 1.5 cm (pT1c).. 2. Histologic grade: 3/3 (tubule formation: 3/3,. nucle... |
166 | Case 16 | Important Radiologic | HR(−) HER2(+) Breast Cancer | Important Radiologic. Findings. 117 118 119. |
172 | Case 16 | Patient History | HR(−) HER2(+) Breast Cancer | Patient History and Progress. Female/57 years old, post-menopause.. Self-detected palpable mass lesion on left. breast.. No family history.. Hypothyroidism (taking on synthroid).. 16.2. |
159 | Case 16 | Courses of Treatment | HR(−) HER2(−) Breast Cancer | 16.1. . Courses of Treatment. Neoadjuvant chemotherapy (#4 cycles of. doxorubicin and cyclophosphamide + #4. cycles of docetaxel) + Operation + Post-. operative radiation therapy.. Operation. 117. Pathology Report. No residual tumor with foamy histiocytic. collection. . 1. Post-chemotherapy status.. . 2. Lymp... |
167 | Case 16 | Important Radiologic | HR(−) HER2(−) Breast Cancer | Important Radiologic. Findings. 109 110 111. 112. HR(−) HER2(−) Breast Cancer. 630. . . . . E. S. Lee et al.. 631. . After Neoadjuvant. Chemotherapy. 113 114 115. 116. 16.3. |
173 | Case 16 | Patient History | HR(−) HER2(−) Breast Cancer | Patient History and Progress. Female/42 years old, pre-menopause.. Self-detected palpable mass lesion on left. breast.. No family history.. s/p Cholecystectomy, s/p appendectomy, s/p. vocal cord operation.. 16.2. |
160 | Case 16 | Courses of Treatment | Local Recurrence | 16.1. . Courses of Treatment. Left breast DCIS → Operation → Adjuvant. therapy → Left breast recurrence (DCIS).. Primary Treatment. 116. 117. Operation. 118. Pathology Report. Ductal Carcinoma In Situ. . 1. Size of tumor: 3.0 cm (pTis).. . 2. Nuclear grade: low.. . 3. Necrosis: present.. . 4. Architectural pattern... |
174 | Case 16 | Patient History | Local Recurrence | Patient History and Progress. Female/43 years old, pre-menopause.. Screen detected mass lesion on left breast 7. o’clock direction.. Outside result of biopsy: Ductal carcinoma in. situ.. No family history.. No comorbidities.. 16.2. |
161 | Case 16 | Courses of Treatment | Metastatic Breast Cancer | 16.1. . Courses of Treatment. Left breast cancer → Operation → Adjuvant. therapy → Ipsilateral axillary lymph node. recurrence.. Primary Treatment. pT2N1a(sn).. Size of tumor: 2.5 cm and 1.0 cm, lymph. node: 1/2, size of metastatic carcinoma: 2.1 mm.. Result. Intensity Positive %. Estrogen. receptor. Strong (8/8). 3... |
175 | Case 16 | Patient History | Metastatic Breast Cancer | Patient History and Progress. Female/46 years old, post-menopause.. No family history.. S/p myomectomy & bilateral salpingo-. oophorectomy.. 16.2. |
176 | Case 17 | Courses of Treatment | Benign and Proliferative | 17.1. . Courses of Treatment. →2021-09-17 excision, Rt.. Pathology Report. Diagnosis. • Breast, right, excision:. –. – Atypical ductal hyperplasia involving. mammary cyst.. –. – Usual ductal hyperplasia, focal with. microcalcification.. 18. |
184 | Case 17 | Important Radiologic | Benign and Proliferative | Important Radiologic. Findings. 30. 31. . Benign and Proliferative Case Series. 38. . 17.3. |
190 | Case 17 | Patient History | Benign and Proliferative | Patient History and Progress. Female/39 years old, pre-menopause.. Screen detected mass lesion on right breast 9. o’clock direction.. No family history.. s/p appendectomy (cecal cancer), s/p hyster. ectomy, and bilateral salpingo-oophorectomy.. s/p partial hepatectomy.. 17.2. |
177 | Case 17 | Courses of Treatment | Carcinoma In Situ | 17.1. . Courses of Treatment. Operation + Tamoxifen 20 mg/day for 5 years.. Operation. 79. 80. Pathology Report. Ductal carcinoma in situ, pathological TN cat. egory (AJCC 2017): pTis(Paget)N0(sn). . 1. Size of tumor: 1.5 cm (pTis(Paget)).. . 2. Nuclear grade: high.. . 3. Necrosis: present.. . 4. Architectural. p... |
185 | Case 17 | Important Radiologic | Carcinoma In Situ | Important Radiologic. Findings. 75 76 77. 78. 17.3. |
191 | Case 17 | Patient History | Carcinoma In Situ | Patient History and Progress. Female/40 years old, pre-menopause.. Screen detected nodule and microcalcification. on upper outer portion of right breast.. No family history.. No comorbidities.. 17.2. |
178 | Case 17 | Courses of Treatment | HR(+) HER2(+) Breast Cancer | 17.1. . Courses of Treatment. Operation + Adjuvant chemotherapy (#4. cycles of doxorubicin and cyclophospha. mide) + Trastuzumab + Tamoxifen 20 mg/day.. . . . 92 93. 94. Pathology Report. [Right].. . 1. Ductal carcinoma in situ.. . (a) Size of tumor: 0.7 cm (pTis).. . (b) Nuclear grade: low.. . (c) Necrosis:... |
186 | Case 17 | Important Radiologic | HR(+) HER2(+) Breast Cancer | Important Radiologic. Findings. 88 89 90. 91. 17.3. |
192 | Case 17 | Patient History | HR(+) HER2(+) Breast Cancer | Patient History and Progress. Female/38 years old, post-menopause.. Self-detected palpable mass lesion on left. breast 1 o’clock direction.. Family history of prostate cancer, maternal. father.. S/P salpingo-oophorectomy (2022).. BRCA 2 mutation carrier.. 17.2. |
179 | Case 17 | Courses of Treatment | HR(+) HER2(-) Breast Cancer | Courses of Treatment. Operation + Post-operative radiation ther. apy + Tamoxifen 20 mg/day.. Operation. Left breast conserving surgery, sentinel lymph. sive intraductal component: present).. 5. Skin: no involvement of tumor.. 6. Surgical margins:. . (a) superior margin: 5 mm.. . (b) inferior margin: (see note 1)... |
187 | Case 17 | Important Radiologic | HR(+) HER2(-) Breast Cancer | Important Radiologic. Findings. See Figs. 84, 85, 86 and 87.. 17.3. |
193 | Case 17 | Patient History | HR(+) HER2(-) Breast Cancer | o’clock direction.. No family history.. S/P Lumbar spine disc herniation operation,. s/p pain block in lumbar spine.. S/p hormone replacement due to amenorrhea.. 17.2. |
180 | Case 17 | Courses of Treatment | HR(−) HER2(+) Breast Cancer | 17.1. . Courses of Treatment. Operation + Adjuvant chemotherapy (#4 cycles. of doxorubicin and cyclophosphamide + #4. cycles of docetaxel and trastuzumab) + Post-. operative radiation therapy + Trastuzumab.. Operation. 126. Pathology Report. Invasive Ductal Carcinoma. 1. Size of tumor: 1.8 and 1.5 cm (pT1c(2))..... |
188 | Case 17 | Important Radiologic | HR(−) HER2(+) Breast Cancer | Important Radiologic. Findings. 122 123 124. 125. . HR(−) HER2(+) Breast Cancer. 498. . . . 17.3. |
194 | Case 17 | Patient History | HR(−) HER2(+) Breast Cancer | Patient History and Progress. Female/41 years old, pre-menopause.. Self-detected palpable mass lesion on left. breast.. Family history of breast cancer, aunt. (maternal).. S/P Lumbar spine disc operation.. BRCA 1 and 2 mutation: Not detected,. MUTYH VUS (variant of uncertain).. 17.2. |
181 | Case 17 | Courses of Treatment | HR(−) HER2(−) Breast Cancer | 17.1. . Courses of Treatment. Operation + Adjuvant chemotherapy (#2. cycles of doxorubicin and cyclophosphamide,. refuse) + Post-operative radiation therapy.. Operation. 122. Pathology Report. Invasive Ductal Carcinoma. 1. Size of tumor: 1.3 cm (pT1c).. 2. Histologic grade: 3/3 (tubule formation: 3/3,. nuclear ple... |
189 | Case 17 | Important Radiologic | HR(−) HER2(−) Breast Cancer | Important Radiologic. Findings. 118 119 120. 121. 17.3. |
195 | Case 17 | Patient History | HR(−) HER2(−) Breast Cancer | Patient History and Progress. Female/70 years old, post-menopause.. Screen detected mass at the upper outer quad. rant of the left breast.. Family history of breast cancer, niece.. h/o Tuberculosis, s/p appendectomy, s/p. myomectomy.. BRCA 1 and 2 mutation: Not tested.. 17.2. |
182 | Case 17 | Courses of Treatment | Local Recurrence | 17.1. . Courses of Treatment. Right breast DCIS → Operation → Adjuvant. therapy → Right breast recurrence (mucinous. carcinoma).. Primary Treatment. 122. Operation. 123. Pathology Report. Ductal Carcinoma In Situ. . 1. Post-excisional biopsy status.. . 2. Size of tumor: 1.5 cm, residual.. . 3. Nuclear grade: high..... |
196 | Case 17 | Patient History | Local Recurrence | Patient History and Progress. Female/43 years old, pre-menopause.. Screen detected mass lesion on right breast 7. o’clock direction.. Outside result of mammotome biopsy: ductal. carcinoma in situ.. No family history.. s/p Total thyroidectomy (thyroid cancer).. BRCA 2 VUS (variant of uncertain).. 17.2. |
183 | Case 17 | Courses of Treatment | Metastatic Breast Cancer | 17.1. . Courses of Treatment. Right breast cancer → Operation → Adjuvant. therapy → Ipsilateral axillary lymph node. recurrence.. Primary Treatment. Estrogen. receptor. Strong. (7/8). 3. 1/3–2/3. Progesterone. receptor. Strong. (7/8). 2. >2/3. C-erbB2. Negative. (0). Ki-67. Positive in. 15% of. tumor. cells. Adjuvant ... |
197 | Case 17 | Patient History | Metastatic Breast Cancer | Patient History and Progress. Female/69 years old, post-menopause.. Family history of breast cancer, daughter.. BRCA. 1. mutation: VUS. (variant. of. uncertain).. 17.2. |
198 | Case 18 | Courses of Treatment | Benign and Proliferative | 18.1. . Courses of Treatment. →2021-08-27 excision, Rt.. Pathology Report. Diagnosis. • Breast, right, excision:. –. – Atypical ductal hyperplasia with micro-. calcification.. Post-excision status.. –. – Intraductal papilloma.. C. W. Lee et al.. 39. . . 19. |
206 | Case 18 | Important Radiologic | Benign and Proliferative | Important Radiologic. Findings. 32. 33. 18.3. |
212 | Case 18 | Patient History | Benign and Proliferative | Patient History and Progress. Female/57 years old, pre-menopause.. Screen detected mass lesion on right breast. 9 ~ 10 o’clock direction.. No family history.. No comorbidities.. s/p Right breast excision.. 18.2. |
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