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1 | TGF-beta1 Improves Biomechanical Strength by Extracellular Matrix Accumulation Without Increasing the Number of Tenogenic Lineage Cells in a Rat Rotator Cuff Repair Model | Trial Systematic Review Project | BACKGROUND: Transforming growth factor beta1 (TGF-beta1) positively regulates the tenogenic marker genes scleraxis ( Scx) and tenomodulin ( Tnmd) in mesenchymal progenitors in vitro. However, little is known about the effect of TGF-beta1 on the expression of tenogenic markers during rotator cuff (RC) healing in rats.
H... |
1 | A prospective study of carpal tunnel syndrome: workplace and individual risk factors | Diagnosis and Treatment of Carpal Tunnel Syndrome CPG | OBJECTIVES: To quantify the risk for carpal tunnel syndrome (CTS) from workplace physical factors, particularly hand activity level and forceful exertion, while taking into account individual factors including age, gender, body mass index (BMI), and pre-existing medical conditions. METHODS: Three healthcare and manufac... |
1 | Should we be analysing breast reduction specimens? A systematic analysis of over 1,000 consecutive cases | Reduction Mammoplasty for Female Breast Hypertrophy | BACKGROUND: Reduction mammoplasty (RM) continues to be popular. The reported incidence of occult breast carcinoma in these specimens varies between 0.05 and 1.8 %. Literature review reveals a wide discrepancy in study methodology, outcome measures, and even what is constituted as a "significant" result. We set out to i... |
0 | Long-Term Effects of Glucosamine and Chondroitin Sulfate on the Progression of Structural Changes in Knee Osteoarthritis: Six-Year Followup Data From the Osteoarthritis Initiative | OAK 3 - Non-arthroplasty tx of OAK | OBJECTIVE: To examine the long-term (6-year) effect of combined glucosamine (Glu) and chondroitin sulfate (CS) treatment on cartilage volume in knee osteoarthritis (OA).
METHODS: Participants were from the Osteoarthritis Initiative progression and incidence subcohorts, had magnetic resonance imaging (MRI) of the target... |
0 | Osteoclasts in multiple myeloma are derived from Gr-1+CD11b+myeloid-derived suppressor cells | MSTS 2018 - Femur Mets and MM | Osteoclasts play a key role in the development of cancer-associated osteolytic lesions. The number and activity of osteoclasts are often enhanced by tumors. However, the origin of osteoclasts is unknown. Myeloid-derived suppressor cells (MDSCs) are one of the pre-metastatic niche components that are induced to expand b... |
0 | Antimicrobial and enzyme-responsive multi-peptide surfaces for bone-anchored devices | Dental Implant Infection | Functionalization of dental and orthopedic implants with multiple bioactivities is desirable to obtain surfaces with improved biological performance and reduced infection rates. While many approaches have been explored to date, nearly all functionalized surfaces are static, i.e., non-responsive to biological cues. Howe... |
0 | A Systematic Review and Meta-Analysis of Ilizarov Methods in the Treatment of Infected Nonunion of Tibia and Femur | DoD SSI (Surgical Site Infections) | BACKGROUND: Infected nonunion of tibia and femur are common in clinical practice, however, the treatment of these diseases has still been a challenge for orthopaedic surgeons. Ilizarov methods can eradicate infection, compensate bone defects and promote the bone union through progressive bone histogenesis. The objectiv... |
1 | National trauma databank analysis of mortality and limb loss in isolated lower extremity vascular trauma | DoD LSA (Limb Salvage vs Amputation) | OBJECTIVES: Lower extremity injury is common in trauma patients; however, the influence of arterial injury on devastating patient and limb outcomes can be confounded by the presence and physiological derangement of concomitant head or thoracoabdominal injuries. We analyzed isolated lower extremity injuries with an arte... |
0 | Bacterial endocarditis complicating systemic lupus erythematosus | Prevention of Orthopaedic Implant Infection in Patients Undergoing Dental Procedures | Culture proven bacterial endocarditis occurred in 6 of 571 patients with systemic lupus erythematosus (SLE) admitted to the National Institutes of Health (NIH). Although 4 of the patients had a murmur noted on examination prior to developing endocarditis, only one of the 6 had a recognized valvular abnormality. Bacteri... |
0 | Relationships between physical performance and knee and hip osteoarthritis: findings from the European Project on Osteoarthritis (EPOSA) | OAK 3 - Non-arthroplasty tx of OAK | BACKGROUND: poor physical performance (PP) is known to be associated with disability, lower quality of life and higher mortality rates. Knee and hip osteoarthritis (OA) might be expected to contribute to poor PP, through joint pain and restricted range of movement. Both clinical and self-reported OA are often used for ... |
0 | Tibial component rotation assessment using CT scan in medial and lateral unicompartmental knee arthroplasty | Surgical Management of Osteoarthritis of the Knee CPG | BACKGROUND: Rotation of tibial component has not been analysed in literature for unicompartmental knee arthroplasty. The purpose of the study was to determine and compare the rotation of medial and lateral unicompartmental knee arthroplasty (UKA) tibial components. We assumed both components (lateral and medial) were p... |
1 | Functional outcome of tibial fracture with acute compartment syndrome and correlation to deep posterior compartment pressure | DOD - Acute Comp Syndrome CPG | AIM: To measure single baseline deep posterior compartment pressure in tibial fracture complicated by acute compartment syndrome (ACS) and to correlate it with functional outcome.
METHODS: Thirty-two tibial fractures with ACS were evaluated clinically and the deep posterior compartment pressure was measured. Urgent fas... |
0 | Infection of a total knee arthroplasty by Candida parapsilosis. A case report of successful treatment by joint reimplantation with a literature review | Prevention of Orthopaedic Implant Infection in Patients Undergoing Dental Procedures | This article describes a case of total knee infection by Candida parapsilosis treated by joint reimplantation. Surgical treatment consisted of resection arthroplasty with wound stablization by external fixation. Antibiotic treatment consisted of 6 weeks of intravenous amphotericin B and 7 weeks of oral 5-fluorocytosine... |
0 | Protein interaction and microRNA network analysis in osteoarthritis meniscal cells | AMP (Acute Meniscal Pathology) | Osteoarthritis is the most common form of arthritis among elderly adults. Herein, we performed protein-protein interaction (PPI) and miRNA network analysis to evaluate the global correlation between miRNA regulation and the PPI network in human osteoarthritis. Our results showed that desmoplakin (DSP), cystatin A (CSTA... |
0 | Peripheral Nerve Blocks for Major Lower Extremity Amputations | DoD LSA (Limb Salvage vs Amputation) | Major lower extremity amputations (above knee amputation or below knee amputation) are common procedures performed for patients with end stage ischemia, infection, and/or disfiguration. Patients undergoing major lower extremity amputations have significant morbidity and mortality. Up to 95% of amputees report chronic p... |
0 | Upper extremity vascular injury: a current in-theater wartime report from Operation Iraqi Freedom | DoD LSA (Limb Salvage vs Amputation) | Past wartime experience and recent civilian reports indicate upper extremity (UE) vascular injury occurs less often and with less limb loss than lower extremity (LE) injury. Given advances in critical care, damage control techniques, and military armor technology, the objective of this evaluation was to define contempo... |
1 | Relationship between Clinical, MRI, and Arthroscopic Findings: A Guide to Correct Diagnosis of Meniscal Tears | AMP (Acute Meniscal Pathology) | <b>Purpose</b> The aim of this prospective study was to compare and correlate clinical, MRI, and arthroscopic findings in cases of suspected meniscal tears. Using arthroscopic findings as the gold standard, the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of clinical inve... |
1 | The occurrence of osteoarthritis at a minimum of ten years after reconstruction of the anterior cruciate ligament | Anterior Cruciate Ligament Injuries CPG | OBJECTIVE: The objective of this study was to evaluate the incidence of radiographic osteoarthritis in the operated knee in comparison with the contralateral knee ten years after a bone-tendon bone patellar autograft ACL-reconstruction and to evaluate to which level patients regain activity ten years after reconstructi... |
0 | A minimally invasive technique for surgical treatment of hallux valgus: Simple, effective, rapid, inexpensive (SERI) | DoD SSI (Surgical Site Infections) | Purpose: Several bony and soft tissue procedures have been described for the treatment of hallux valgus, and currently mini-invasive surgical techniques are preferred in order to reduce surgical trauma, complications, time of surgery and to allow an earlier recovery. The aim of this study is to analyse a series of 1,00... |
0 | Signalling pathways involved in endocrine resistance in breast cancer and associations with epithelial to mesenchymal transition (Review) | MSTS 2018 - Femur Mets and MM | Both de novo and acquired endocrine resistance constitute a major therapeutic problem for treatment of hormone-positive breast cancer. Multiple explanatory mechanisms have been proposed through the study of cellular models which focus principally on receptor tyrosine kinase mediated signalling pathways utilizing src, P... |
0 | Proteomics-based strategy to delineate the molecular mechanisms of the metastasis suppressor gene BRMS1 | MSTS 2018 - Femur Mets and MM | The breast cancer metastasis suppressor 1 (BRMS1) gene has been shown to suppress metastasis without affecting the growth of the primary tumor in mouse models. It has also been shown to suppress the metastasis of tumors derived from breast, melanoma, and, more recently, ovarian carcinoma (see ref 1). However, how BRMS1... |
0 | A meta-analysis of prior corticosteroid use and fracture risk | Management of Hip Fractures in the Elderly | The relationship between use of corticosteroids and fracture risk was estimated in a meta-analysis of data from seven cohort studies of approximately 42,000 men and women. Current and past use of corticosteroids was an important predictor of fracture risk that was independent of prior fracture and BMD. INTRODUCTION: Th... |
0 | Development and relative validity of a new field instrument for detection of geriatric cachexia: preliminary analysis in hip fracture patients | Hip Fx in the Elderly 2019 | BACKGROUND: Geriatric cachexia is distinct from other age-related muscle wasting syndromes; however, detection and therefore treatment is challenging without the availability of valid instruments suitable for application in the clinical setting. This study assessed the sensitivity and specificity of a newly developed s... |
0 | Very long-term osteoarthritis rate after anterior cruciate ligament reconstruction: 182 cases with 22-yearâ?? follow-up | OAK 3 - Non-arthroplasty tx of OAK | Background: Few data are available on the 20-year outcomes of anterior cruciate ligament (ACL) reconstruction. The purpose of this study was to assess the prevalence and risk factors of knee osteoarthritis at least 20 years after ACL reconstruction. Hypothesis: Factors associated with progression to knee osteoarthritis... |
0 | Pakistan's Health System Against COVID-19: Where Do Things Stand? | Coronavirus Disease 2019 (COVID-19) | The national response of Pakistan's health system to COVID-19 was assessed by applying a framework of three distinct tiers. The first tier assessed politico-economic ecosystems: lockdown procedures, contact-screening, monetary/organisational arrangements for economically deprived groups, and travel restrictions. The se... |
0 | Adjuvant denosumab in postmenopausal patients with hormone receptor-positive breast cancer (ABCSG-18): disease-free survival results from a randomised, double-blind, placebo-controlled, phase 3 trial | AMP (Acute Meniscal Pathology) | BACKGROUND: In postmenopausal women with hormone receptor-positive, early-stage breast cancer, treatment with adjuvant aromatase inhibitors is the standard of care, but it increases risk for osteoporosis and fractures. Results from the ABCSG-18 trial showed that use of denosumab as an adjuvant to aromatase inhibitor th... |
0 | Sagittal plane balancing in the total knee arthroplasty | Surgical Management of Osteoarthritis of the Knee CPG | Postoperative stiffness or instability may result from a total knee arthroplasty imbalanced in the sagittal plane. Total knee arthroplasty instrumentation systems differ in the basic strategies used to assure this balance. In an anterior referencing system, changes in femoral size affect flexion gap tightness, and femo... |
0 | Breast reduction surgery in the UK and Ireland - Current trends | Panniculectomy & Abdominoplasty CPG | Introductions: This paper reviews the current status of bilateral breast reduction surgery in the UK and Ireland; It examines the pre-operative, operative and postoperative management of women. Patients and Methods: A questionnaire established information about surgeons' experience, bilateral breast reduction workload,... |
0 | Knee effusion affects knee mechanics and muscle activity during gait in individuals with knee osteoarthritis | OAK 3 - Non-arthroplasty tx of OAK | OBJECTIVE: To test the hypothesis that knee effusion presence in those with knee osteoarthritis (OA) alters knee joint muscle activation patterns and sagittal plane mechanics during gait.
METHODS: Thirty-five patients with medial compartment knee OA were assessed for the presence of effusion using a brush test. Based o... |
0 | Risk of bleeding in patients with continued dual antiplatelet therapy during orthopedic surgery | Hip Fx in the Elderly 2019 | Background:To prevent risk of life-threatening stent thrombosis, all patients need to undergo dual antiplatelet therapy (DAPT) for at least 6 weeks to 12 months after stent implantation. If DAPT is continued during noncardiac surgery, there is a risk of severe bleeding at the surgical site. Our study was to assess the ... |
0 | Risk factors for open-angle glaucoma in Nigeria: results from the Nigeria National Blindness and Visual Impairment Survey | Upper Eyelid and Brow Surgery | BACKGROUND: The glaucoma-specific blindness prevalence in Nigeria (0.7 %, 95 % CI 0.6-0.9 %) among those aged >/=40 years is one of the highest ever reported. This study determined the risk factors for open-angle glaucoma (OAG) in adults examined in the Nigeria National Blindness and Visual Impairment Survey. METHODS: ... |
0 | Differences in the Radius of Curvature Between Femoral Condyles: Implications for Osteochondral Allograft Matching | Osteochondritis Dissecans 2020 Review | BACKGROUND: The radius of curvature (ROC) is an important variable related to potential cartilage incongruities in the transplantation of a large femoral osteochondral allograft. The anterior-posterior length (APL) of a condyle is used as a criterion for donor-graft acceptance. We hypothesized that there would be a lin... |
0 | Association of prostate-specific antigen levels and patterns of benign and malignant uptake detected. on bone scintigraphy in patients with newly diagnosed prostate carcinoma | MSTS 2018 - Femur Mets and MM | The bone scan patterns of benign and malignant uptake in 432 patients with newly diagnosed prostate carcinoma were reviewed in relation to prostate-specific antigen (PSA) levels determined within 4 months of scintigraphy. Scan results were categorized in terms of likelihood of metastatic disease and anatomical location... |
0 | Statins and hip fracture prevention - a population based cohort study in women | Management of Hip Fractures in the Elderly | OBJECTIVE: To study the association of long-term statin use and the risk of low-energy hip fractures in middle-aged and elderly women. DESIGN: A register-based cohort study. SETTING: Finland. PARTICIPANTS: Women aged 45-75 years initiating statin therapy between 1996 and 2001 with adherence to statins >/=80% during the... |
1 | Conversion From Limb Salvage to Late Amputation: Lessons Learned From Recent Battlefields With Application to Civilian Trauma | DoD LSA (Limb Salvage vs Amputation) | Battlefield injuries and high-energy civilian trauma present orthopaedic surgeons with treatment challenges. Despite efforts at limb salvage, some patients elect late amputation. This article reviews risk factors that predispose to late amputation. Using a MEDLINE search, English language peer-reviewed articles from 19... |
0 | Subchondral chitosan/blood implant-guided bone plate resorption and woven bone repair is coupled to hyaline cartilage regeneration from microdrill holes in aged rabbit knees | PJI DX Updated Search | OBJECTIVE: Little is known of how to routinely elicit hyaline cartilage repair tissue in middle-aged patients. We tested the hypothesis that in skeletally aged rabbit knees, microdrill holes can be stimulated to remodel the bone plate and induce a more integrated, voluminous and hyaline cartilage repair tissue when tre... |
1 | Resilience and Other Possible Outcomes After Mild Traumatic Brain Injury: a Systematic Review | DoD PRF (Psychosocial RF) | The relation between resilience and mild traumatic brain injury (TBI) outcome has been theorized but empirical studies have been scarce. This systematic review aimed to describe the research in this area. Electronic databases (Medline, CINAHL, PsychINFO, SPORTdiscus, and PILOTS) were searched from inception to August 2... |
0 | Risk factors associated with the occurrence of hip fracture in Japanese patients with rheumatoid arthritis: a prospective observational cohort study | Surgical Management of Osteoarthritis of the Knee CPG | Risk factors associated with the occurrence of hip fracture in Japanese patients with rheumatoid arthritis (RA) were evaluated in a prospective, observational cohort study. Physical disability, advanced age, history of total knee replacement (TKR), and low body mass index (BMI) appear to be associated with the occurren... |
1 | Outcome of endoscopic carpal tunnel release in patients with chronic nonhand pain compared with those without chronic pain | Diagnosis and Treatment of Carpal Tunnel Syndrome CPG | PURPOSE: This prospective observational study compared the outcomes of single-port endoscopic carpal tunnel release in patients taking narcotic pain medication chronically for back, neck, leg, or other bodily pain for more than 3 months, with patients not taking chronic narcotic pain medication (control group). METHODS... |
0 | Life event timing and the emotional consequences of surgical menopause for Asian-Pacific women in Guam | DoD PRF (Psychosocial RF) | Using Behavior Risk Factor Survey data (N = 398), this study tests the age-norms hypothesis by examining the emotional consequences of the timing of surgical menopause for women in Guam's Asian-Pacific community. The results of the study are supportive of the hypothesis that off-scheduled life events result in consider... |
1 | A meta-analysis of the incidence of anterior cruciate ligament tears as a function of gender, sport, and a knee injury-reduction regimen | Anterior Cruciate Ligament Injuries CPG | PURPOSE: The literature has shown that anterior cruciate ligament (ACL) tear rates vary by gender, by sport, and in response to injury-reduction training programs. However, there is no consensus as to the magnitudes of these tear rates or their variations as a function of these variables. For example, the female-male A... |
0 | (untitled) | SR for PM on OA of All Extremities | Developmental dysplasia of the hip (DDH) can lead to the later development of chronic pain, osteoarthritis, and limitations in activity. Screening for DDH has been practiced for over 40 years, but recommendations from major professional societies differ. To synthesize the evidence on risks and benefits of screening for... |
1 | Does preoperative rehabilitation improve patient-based outcomes in persons who have undergone total knee arthroplasty? A systematic review | Surgical Management of Osteoarthritis of the Knee CPG | BACKGROUND: Common clinical practice includes attempts to improve pain, function, motion, and patient independence before total knee arthroplasty (TKA) surgery. Although preoperative rehabilitation often is prescribed, it is unknown whether this care improves patient outcomes after TKA surgery. OBJECTIVE: To focus on h... |
0 | Articular surface replacement of the hip: a prospective single-surgeon series | Management of Hip Fractures in the Elderly | We present the early clinical and radiological results of Articular Surface Replacement (ASR) resurfacings in 214 hips (192 patients) with a mean follow-up of 43 months (30 to 57). The mean age of the patients was 56 years (28 to 74) and 85 hips (40%) were in 78 women. The mean Harris hip score improved from 52 (11 to ... |
0 | Men's adjustment to spinal cord injury: the unique contributions of conformity to masculine gender norms | DoD PRF (Psychosocial RF) | Men constitute 82% of the approximately 250,000 people in the United States living with a spinal cord injury. Unfortunately, however, little is known about the impact of men's adherence to gender norms on their adjustment to such injuries. The present investigation examined the utility of masculine norms in explaining ... |
0 | Correlation between cortical excitabilityand local B-amyloid deposition as evaluated by MEG and PIB-PET | Diagnosis and Treatment of Carpal Tunnel Syndrome CPG | Background: It has been noticed that patients with Alzheimer's disease (AD) often show seizures [Hause et al, 1986], however the underlying pathomechanisms were not completely understood. Recently, frequent occurrence of seizures were also found in transgenic mice for AD model [Palop et al. 2007], and Bousche et al (20... |
0 | Antibiotic prophylaxis: current recommendations in plastic surgery | Panniculectomy & Abdominoplasty CPG | Background: Guidelines for prophylactic antibiotics in surgery have long been established; however, few have focused on recommendations in plastic surgery. Surgical site infection rates remain low, yet the use of prophylactic antibiotics has surged in the past 30Â years. This article summarizes current recommendations ... |
1 | Analysis of synovial fluid in culture-negative samples of suspicious periprosthetic infections | PJI DX Updated Search | Synovial fluid analysis can help to rule out a periprosthetic infection. The goal of this study was to evaluate the prognostic significance of synovial fluid suspicious for a periprosthetic infection given the synovial leukocyte count and percent of neutrophils. From August 2006 to November 2008, patients who had synov... |
0 | Pain, fear of falling and stair climbing ability in patients with knee osteoarthritis before and after knee replacement: 6 month follow-up study | Surgical Management of Osteoarthritis of the Knee CPG | OBJECTIVES: (1) to evaluate the change in time of pain, stair climbing ability and fear of falling (FOF), (2) to determine the association between pain, stair climbing ability and FOF for patients with knee osteoarthritis (OA) following the knee replacement over the course of six months, (3) and to compare the results ... |
0 | Supplementary vitamin E does not affect the loss of cartilage volume in knee osteoarthritis: a 2 year double blind randomized placebo controlled study | OAK 3 - Non-arthroplasty tx of OAK | OBJECTIVE: To determine whether vitamin E affects change in cartilage volume in patients with knee osteoarthritis (OA). METHODS: In a double blind, placebo controlled trial, 136 patients with knee OA (American College of Rheumatology clinical and radiographic criteria) were randomized to receive vitamin E (500 IU) or p... |
1 | Intraoperative three-dimensional imaging in the treatment of distal radius fractures | Distal Radius Fractures | INTRODUCTION: In operative treatment of distal radius fractures satisfying outcome mainly relies on anatomical fracture reduction and correct implant placement. Examination with two-dimensional fluoroscopy may not provide reliable information about this. The aim of this study was to determine the effectiveness of addit... |
0 | Bearing dislocation and progression of osteoarthritis after mobile-bearing unicompartmental knee arthroplasty vary between asian and western patients: A meta-analysis | OAK 3 - Non-arthroplasty tx of OAK | Implant survivorship is reported to be lower and complications, particularly bearing dislocation, are reported to be more frequent in Asian than in Western patients with medial knee osteoarthritis (OA) undergoing Oxford® Phase III unicompartmental knee arthroplasty (UKA). To date, however, these complications have not... |
0 | The plastic surgery postcode lottery in England | Reduction Mammoplasty for Female Breast Hypertrophy | INTRODUCTION AND AIM: The National Health Service (NHS) provides treatment free at the point of delivery to patients. Elective medical procedures in England are funded by 149 independent Primary Care Trusts (PCTs), which are each responsible for patients within a defined geographical area. There is wide variation of av... |
0 | The Chemokine Receptor CXCR4 and c-MET Cooperatively Promote Epithelial-Mesenchymal Transition in Gastric Cancer Cells | MSTS 2018 - Femur Mets and MM | The C-X-C motif chemokine receptor 4 (CXCR4) pathway can promote tumor metastasis but is dependent on cross talk with other signaling pathways. The MET proto-oncogene (c-MET) participates in metastasis and is highly expressed in gastric cancer. However, the relationship between CXCR4 and c-MET signaling and their mecha... |
0 | Comparison of The Effects of Concentric And Eccentric Isokinetic Exercises in Patients With Knee Osteoarthritis | OAK 3 - Non-arthroplasty tx of OAK | This study aims to compare the effects of concentric and eccentric isokinetic exercises on proprioception and muscle architecture in patients with knee osteoarthritis. 69 patients will be included in this study. Patients will be divided into three groups; concentric exercise group (n:23), eccentric exercise group (n:23... |
0 | Finite element analysis of the proximal femur and hip fracture risk in older men | Management of Hip Fractures in the Elderly | Low areal BMD (aBMD) is associated with increased risk of hip fracture, but many hip fractures occur in persons without low aBMD. Finite element (FE) analysis of QCT scans provides a measure of hip strength. We studied the association of FE measures with risk of hip fracture in older men. A prospective case-cohort stud... |
0 | Establishing recommendations for physical medicine and rehabilitation: the SOFMER methodology | Surgical Management of Osteoarthritis of the Knee CPG | OBJECTIVE: The development of a rigorous methodology based on published results of clinical trials, evaluation of daily practice in France and multidisciplinary expert opinion to elaborate recommendations for rehabilitation interventions. METHODS AND RESULTS: The following describes the methodology of SOFMER (Societe F... |
0 | Role of Free Iliac Crest Flap in Foot and Ankle Reconstruction | DoD LSA (Limb Salvage vs Amputation) | Background Reconstruction of extensive bone and compound defects in the foot and ankle is challenging. This cross-sectional study aimed to assess the outcomes of free iliac crest flap in foot and ankle reconstruction. Methods We retrospectively reviewed patient records and identified 13 cases with 1 osseous and 12 comp... |
0 | Dual hip bone mineral density in postmenopausal women: geometry and effect of physical activity | Management of Hip Fractures in the Elderly | The objectives of this study were to (1) obtain both femoral neck strength (FNS) and hip axis length (HAL) values from left and right femurs (regardless of hip dominance) measured by DXA and evaluate their relationship with BMD of all hip regions including total hip, (2) determine if there is a difference between domin... |
0 | Incidence of deep infection in aseptic revision THA using vancomycin-impregnated impacted bone allograft | Prevention of Orthopaedic Implant Infection in Patients Undergoing Dental Procedures | The addition of antibiotic to cement is a frequent practice in aseptic revision hip surgery There is concern about adding vancomycin to cement due to potential effects on mechanical properties and prolonged elution of subtherapeutic levels antibiotic. Bone allografts can store and provide high levels of vancomycin to s... |
0 | Treatment of unstable fractures of the distal radius by external fixation | Distal Radius Fractures | The Roger Anderson external fixator was used in the treatment of unstable fractures of the distal radius in 52 patients, and the results evaluated after a follow-up averaging 58 months. The indications for its use were failure to maintain adequate closed reduction using plaster, and instability of the fracture as deter... |
0 | Denosumab treatment of prostate cancer with bone metastases and increased urine N-telopeptide levels after therapy with intravenous bisphosphonates: results of a randomized phase II trial | MSTS 2018 - Femur Mets and MM | PURPOSE: Patients with bone metastases have high rates of RANKL driven bone resorption and an increased risk of skeletal morbidity. Osteoclast mediated bone resorption can be assessed by measuring urine N-telopeptide and can be inhibited by denosumab, a fully human antibody against RANKL.
MATERIALS AND METHODS: Eligibl... |
1 | Current Concepts: Evaluation and Treatment of Discoid Meniscus in the Pediatric Athlete | AMP (Acute Meniscal Pathology) | Discoid meniscus is a rare anatomical variant with altered morphology and structure that can sometimes present symptomatically, typically in the pediatric population. The discoid meniscus is usually in the lateral compartment of the knee and is characterized by a partial or complete filling-in of central meniscal tissu... |
0 | A modified surgical technique for neglected fracture of lateral humeral condyle in children | Pediatric Supracondylar Humerus Fracture 2020 Review | Operative treatment for neglected fracture of lateral humeral condyle (LHC) is difficult because of contracted muscle, fibrous tissue formation, and indistinct bony edges. Its success depends on the ability to preserve blood supply during the surgery. We retrospectively reviewed eight cases of neglected fracture of LHC... |
0 | Fluoride for treating postmenopausal osteoporosis | Management of Hip Fractures in the Elderly | BACKGROUND: Osteoporosis is a condition that results in an increased risk of fractures due to the reduction of bone volume, which is caused by an imbalance between bone formation and bone resorption. Because of this property, fluoride has been used for over 30 years as a treatment for osteoporosis. OBJECTIVES: To asses... |
0 | Hip fractures among the elderly: factors associated with in-hospital mortality | Management of Hip Fractures in the Elderly | Factors associated with mortality were examined for 27,370 hip fracture patients aged 65 years or older in Maryland hospitals, using discharge data for 1979-1988. Variables of interest included sociodemography, principal medical and injury diagnoses, E-code, year, disposition, and hospital. For both white males and whi... |
0 | Dextromethorphan Use in Multimodal Analgesia Regimens for Total Knee Arthroplasty | AAHKS (4) Acetaminophen | Each subject will receive as part of their standard of care a spinal with sedation for intraoperative anesthesia. Subjects will be randomly assigned using computer generated allotment. The group designation will be placed in sealed envelopes. The group listed will determine whether or not they will receive dextromethor... |
0 | Lack of impact of intravenous lidocaine on analgesia, functional recovery, and nociceptive pain threshold after total hip arthroplasty | AAHKS (8) Anesthetic Infiltration | BACKGROUND: The analgesic effect of perioperative low doses of intravenous lidocaine has been demonstrated after abdominal surgery. This study aimed to evaluate whether a continuous intravenous low-dose lidocaine infusion reduced postoperative pain and modified nociceptive pain threshold after total hip arthroplasty.
M... |
0 | In vivo compatibility of Dynesys((R)) spinal implants: a case series of five retrieved periprosthetic tissue samples and corresponding implants | PJI DX Updated Search | PURPOSE: To determine whether particulate debris is present in periprosthetic tissue from revised Dynesys((R)) devices, and if present, elicits a biological tissue reaction. METHODS: Five Dynesys((R)) dynamic stabilization systems consisting of pedicle screws (Ti alloy), polycarbonate-urethane (PCU) spacers and a polye... |
0 | Chronic Q fever in a renal transplant recipient: A case report | PJI DX Updated Search | Q fever is a zoonosis caused by Coxiella burnetii that presents with a wide spectrum of acute and chronic manifestations. Progression to chronic Q fever is frequently associated with valve and vascular prosthesis, aneurisms, pregnancy, immunosuppression, and advanced chronic kidney disease. We present a case of a kidne... |
1 | Do clinical presentation and pre-operative quality of life predict satisfaction with care after total hip or knee replacement? | Surgical Management of Osteoarthritis of the Knee CPG | We conducted a multicentre cohort study of 228 patients with osteoarthritis followed up after total hip or knee replacement. Quality of life and patient satisfaction were assessed by self-administered questionnaires. Patient satisfaction was the dependent variable in a multivariate linear regression model. Independent ... |
0 | The dislocator, early and late: the 3 am phone call | PJI DX Updated Search | Hip dislocation is one of the most common causes of patient and surgeon dissatisfaction following hip replacement. To correctly treat dislocation, the causes must first be understood. Patient factors include age older than 70 years, medical comorbidities, female sex, musculoligamentous laxity, revision surgery, issues ... |
0 | Fibrous dysplasia with acromegaly | Diagnosis and Treatment of Carpal Tunnel Syndrome CPG | McCune-Albright Syndrome (MAS) is a triad of fibrous dysplasia of bone (97%), cafe-au-lait macules (85%) and precocious puberty (52%). It is due to mutation in the Gs protein (alpha) subunit leading to cAMP overproduction. Hyperactive endocrinopathies associated with MAS include Cushing's Syndrome (50%), growth hormone... |
0 | Total hip reconstruction in the anatomically distorted hip. Cemented versus hybrid total hip arthroplasty | Dental Implant Infection | Recent reports in the literature strongly support the idea that cement is the optimum form of fixation of the femoral component in total hip replacement. For hybrid total hip arthroplasty, we used a cemented cup instead of an uncemented cup since this was inevitable in cases of poorly developed acetabulum. The uncement... |
0 | Bone metastases: assessment, management and treatment options | MSTS 2018 - Femur Mets and MM | Cancer cells from a primary tumour can spread to other parts of the body through the bloodstream or the lymphatic system. Bone metastases are common in multiple myeloma, where 70-80% of patients have bone metastases at diagnosis. They are also a common feature in solid tumours such as breast, lung, prostate, thyroid an... |
0 | Recommendations for CTV margins in radiotherapy planning for non melanoma skin cancer | Reconstruction After Skin Cancer | Purpose: To provide practice guidelines for delineating clinical target volume (CTV) for radiotherapy planning of non melanoma (NMSC) skin cancers. Methods and materials: A prospective, single arm, study. Preoperatively, a radiation oncologist outlined the boundary of a gross lesion, and drew 5-mm incremental marks in ... |
0 | Responsiveness and reliability of MRI in knee osteoarthritis: a meta-analysis of published evidence | AMP (Acute Meniscal Pathology) | OBJECTIVE: To summarize literature on the responsiveness and reliability of MRI-based measures of knee osteoarthritis (OA) structural change.
METHODS: A literature search was conducted using articles published up to the time of the search, April 2009. 1338 abstracts obtained with this search were preliminarily screened... |
0 | Tri-axial loading response to anti-gravity running highlights movement strategy compensations during knee injury rehabilitation of a professional soccer player | AMP (Acute Meniscal Pathology) | Anti-gravity treadmills have been used in rehabilitation to manipulate exposure to loading and to prescribe return to outside running. Analysis is typically restricted to the vertical plane, but tri-axial accelerometry facilitates multi-planar analysis with relevance to injury mechanism. In this case a professional mal... |
1 | Influence of compensation status on time off work after carpal tunnel release and rotator cuff surgery: a meta-analysis | Diagnosis and Treatment of Carpal Tunnel Syndrome CPG | BACKGROUND: The assessment of post-surgical outcomes among patients with Workers' Compensation is challenging as their results are typically worse compared to those who do not receive this compensation. These patients' time to return to work is a relevant outcome measure as it illustrates the economic and social implic... |
0 | Developing person-centred practice in hip fracture care for older people | Hip Fx in the Elderly 2019 | AIM: To facilitate a multidisciplinary collaborative approach to developing person-centred practice in hip fracture care for older people.
METHOD: Collaborative inquiry, a form of action research, was used to collect data for this study. It involved exploration of dilemmas, questions and problems that are part of human... |
0 | Inhibitors of hydroxymethylglutaryl-coenzyme A reductase and risk of fracture among older women | MSTS 2022 - Metastatic Disease of the Humerus | BACKGROUND: Inhibitors of hydroxymethylglutaryl-coenzyme A reductase (statins) increase new bone formation in rodents and in human cells in vitro. Statin use is associated with increased bone mineral density of the femoral neck. We undertook a population-based case-control study at six health-maintenance organisations ... |
0 | Patient-specific total knee arthroplasty: The importance of planning by the surgeon | Surgical Management of Osteoarthritis of the Knee CPG | Purpose: The purpose of the study was to evaluate the accuracy of the planning of the patient-specific pin guides in total knee arthroplasty (TKA). This planning was performed primarily by a technician of the company and offered to the surgeon. All parameters of the implantation can either be modified or accepted by th... |
0 | Midterm outcomes following anatomic-based popliteus tendon reconstructions | AMP (Acute Meniscal Pathology) | PURPOSE: The purpose of this study was to document subjective outcomes following anatomic-based reconstruction of the popliteus tendon when the popliteus tendon was the only injured posterolateral knee structure. It was hypothesized that popliteus tendon reconstruction would result in improved patient outcomes after su... |
0 | Statistical aspects of the normal visual field in short-wavelength automated perimetry | Upper Eyelid and Brow Surgery | PURPOSE: To determine the intraindividual and interindividual characteristics of normal sensitivity derived by short-wavelength automated perimetry (SWAP) as a function of threshold algorithm. To determine also the influence of ocular media absorption on the magnitude of the interindividual variation in normal sensitiv... |
0 | Comprehensive Arthroscopic Characterization of Discoid Meniscus Tears and Instability Using the PRiSM Discoid Meniscus Classification | AMP (Acute Meniscal Pathology) | The discoid meniscus is a congenital abnormality, with the vast majority occurring in the lateral meniscus. More commonly seen in pediatric populations, patients present with acute or chronic knee symptoms such as joint line pain, audible or palpable mechanical symptoms, and the inability to achieve terminal extension.... |
0 | Early prediction of femoral head avascular necrosis following neck fracture | Management of Hip Fractures in the Elderly | Femoral neck fracture puts at risk functional prognosis in young patients and can be life-threatening in the elderly. The present study reviews methods of femoral head vascularity assessment following neck fracture, to address the following issues: what is the risk of osteonecrosis? And what, in the light of this risk,... |
0 | Sedation during regional anaesthesia: Patient expectation and experience | Surgical Management of Osteoarthritis of the Knee CPG | To compare the expectation & experience of conscious levels during surgery under regional anaesthesia, with the study conducted previously. Methods: After verbal consent 66 patients were contacted using a questionnaire on the first post operative day, during April 2011 at Regional Orthopaedic Centre in Belfast. Data fo... |
0 | Contemporary pain management in total knee arthroplasty | AAHKS (8) Anesthetic Infiltration | Pain management has become a very important part of postoperative care for total knee arthroplasty patients. Contemporary pain control has evolved from high-dose opioid in the past to state-of-the-art multimodal regimens. These include multiple non-opioid medication such as NSAIDs, COX-2 inhibitors, and gabapentinoid, ... |
0 | Ruptured intercostal artery pseudoaneurysm: A rare cause of acute back pain | PJI DX Updated Search | A 63-year-old man with no relevant medical history presented with acute non-traumatic back pain and was found to have a T8 intercostal artery pseudoaneurysm associated with haemomediastinum on CT of the chest. He was taken to angiography with interventional radiology and the aneurysm was coiled without complication |
0 | Midterm Results of Total Hip Arthroplasty in Patients With High Hip Dislocation After Suppurative Hip Arthritis | DoD SSI (Surgical Site Infections) | Background: Total hip arthroplasty (THA) is technically challenging in patients with high dislocation of the hip secondary to suppurative arthritis. The technical difficulty is attributable to the complex hip anatomy and the potential risk of recurrent infection in these patients. This study investigated the midterm re... |
0 | Risk of cardiovascular events in patients receiving celecoxib: a meta-analysis of randomized clinical trials | SR for PM on OA of All Extremities | Some nonsteroidal anti-inflammatory drugs (NSAIDs), including cyclooxygenase-2 selective inhibitors, have been associated with increased cardiovascular (CV) events in recent clinical trials or observational studies. To determine whether the cyclooxygenase-2 selective inhibitor celecoxib affects CV risk, the incidence o... |
1 | Carpal-tunnel syndrome. Results of a prospective trial of steroid injection and splinting | Diagnosis and Treatment of Carpal Tunnel Syndrome CPG | In order to define the role of steroid injection and splinting as a method of treatment of carpal-tunnel syndrome, a prospective study was performed on fifty hands in forty-one consecutive patients. All hands were treated with a single injection and three weeks of splinting. Follow-up ranged from a minimum of six month... |
1 | Postoperative analgesic efficacy of peripheral levobupivacaine and ropivacaine: a prospective, randomized double-blind trial in patients after total knee arthroplasty | AAHKS (9/10) Regional Nerve Blocks | BACKGROUND: Several previous trials have characterized the intra- and postoperative effects of the recently introduced local anesthetics, levobupivacaine and ropivacaine, for a variety of continuous peripheral nerve blocks.
METHODS: We compared the analgesic efficacy of levobupivacaine 0.125% versus ropivacaine 0.2% vi... |
0 | Fractures in lower limbs with prior amputation. A study of ninety cases | Management of Hip Fractures in the Elderly | Eighty-five lower-limb amputees with ninety subsequent fractures of the residual limb were studied retrospectively. Most of the fractures were managed by non-operative methods, with the exception of unstable intertrochanteric fractures and displaced fractures of the femoral neck. Indications for operative and non-opera... |
0 | Rheumatoid arthritis patients with hip fracture: a nationwide study | Hip Fx in the Elderly 2019 | Summary: The study was to investigate the outcomes of rheumatoid arthritis (RA) patients with hip fractures with a large-scale, population-based, nationwide, case-cohort study using the Taiwan National Health Insurance database. The group has hip fractures at a younger age, higher complication, and mortality rate, whic... |
0 | Modified vertical reduction mammaplasty: Ten years of experience | Reduction Mammoplasty for Female Breast Hypertrophy | Background: Over the years, vertical scar breast reduction has gained more and more importance. This is due to the fact that this technique is associated with smaller scars and absence of scars in the inframammary fold. However, this technique also has some disadvantages, such as the pleating of the vertical scar durin... |
0 | Distal Radius Fractures: Reconstruction Approaches, Planning, and Principles | Distal Radius Fractures | Distal radius fracture (DRF) is a common injury. Treatment options have evolved and now several can be used to address even the most complex fracture patterns. Complex fractures of the distal radius and ulna can be challenging, and specific goals must be kept in mind to achieve definitive anatomical and functional rest... |
0 | Pyoderma gangrenosum following reduction mammaplasty | Reduction Mammoplasty for Female Breast Hypertrophy | The failure of a postoperative local infection to resolve after appropriate antibiotic therapy should prompt consideration of other diagnoses. Reported here is a case of pyoderma gangrenosum, a rare necrotizing disorder, occurring after reduction mammaplasty. The clinical presentation was one of progressive wound deter... |
0 | The radioulnar joints and forearm axis: surgeons' perspective | Distal Radius Fractures | Forearm injuries are common and can vary in complexity. The fractures are easily diagnosed, but the associated soft tissue injuries may not be as obvious. Treatment results are dependent not only on the fracture healing but on the return of normal relationships about the distal radioulnar joint, the interosseous membra... |
0 | Use of a shoulder abduction brace after arthroscopic rotator cuff repair: A study on gait performance and falls | AAHKS (5) Gabapentinoids | Background: Fall prevention is essential in patients after arthroscopic rotator cuff repair because of the high risk of re-rupture. However, there are no reports related to falls that occur during the early postoperative period, while the affected limb is immobilized. Objectives: This study assessed gait performance an... |
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