Title stringlengths 0 905 | Abstract stringlengths 0 11.3k | Container_Title stringlengths 0 126 | Subject listlengths 1 13 |
|---|---|---|---|
Quality Control Mechanisms in Bacterial Translation | Ribosome stalling during translation significantly reduces cell viability, because cells have to spend resources on the synthesis of new ribosomes. Therefore, all bacteria have developed various mechanisms of ribosome rescue. Usually, the release of ribosomes is preceded by hydrolysis of the tRNApeptide bond, but, in some cases, the ribosome can continue translation thanks to the activity of certain factors. This review describes the mechanisms of ribosome rescue thanks to trans-translation and the activity of the ArfA, ArfB, BrfA, ArfT, HflX, and RqcP/H factors, as well as continuation of translation via the action of EF-P, EF-4, and EttA. Despite the ability of some systems to duplicate each other, most of them have their unique functional role, related to the quality control of bacterial translation in certain abnormalities caused by mutations, stress cultivation conditions, or antibiotics. | [
"Molecular Biology",
"Molecular Medicine",
"Biochemistry",
"Biotechnology"
] | |
Monitoring of Pain and Stress in an Infant With Asphyxia During Induced Hypothermia | [
"Pediatrics, Perinatology and Child Health"
] | ||
Mepitel Film is superior to Biafine cream in managing acute radiation‐induced skin reactions in head and neck cancer patients: a randomised intra‐patient controlled clinical trial | Journal of Medical Radiation Sciences | [
"Radiology, Nuclear Medicine and Imaging",
"Radiological and Ultrasound Technology"
] | |
Theory and Practice in Dividend Distribution | [
"Economics and Econometrics"
] | ||
Study on the transplantation of microencapsulated hepatic-like cells derived from umbilical cord blood cells for the treatment of acute hepatic failure in rats | [
"Cell Biology"
] | ||
Status and main growth trends in production of lubricating greases, oil additives, and lubricating-cooling fluids | [
"Energy Engineering and Power Technology",
"Fuel Technology"
] | ||
Domnick Hunter Group plc, UK | [
"Industrial and Manufacturing Engineering",
"Filtration and Separation"
] | ||
Revisión de diciembre de 2007 | [
"Dermatology"
] | ||
Evolution of Hox Clusters in Salmonidae: A Comparative Analysis Between Atlantic Salmon (Salmo salar) and Rainbow Trout (Oncorhynchus mykiss) | [
"Genetics",
"Molecular Biology",
"Ecology, Evolution, Behavior and Systematics"
] | ||
Adequação de recursos humanos ao PSF: percepção de formandos de dois modelos de formação acadêmica em odontologia | O Programa Saúde da Família - PSF foi instituído pelo governo federal objetivando reverter o modelo assistencial. Os recursos humanos envolvidos devem estar preparados para alcançar os objetivos que o PSF propõe. O propósito desse artigo foi avaliar os desejos, percepções e preparo de acadêmicos de Odontologia, em relação aos princípios do PSF, de duas diferentes Faculdades de Odontologia, aqui denominadas Faculdades 1 e 2. Buscou-se ainda analisar se as faculdades tiveram potencial transformador sobre os acadêmicos, graduando-os com compromisso social e sensibilidade humanitária, considerados importantes para aqueles que querem trabalhar no PSF. Questionários individuais foram aplicados por um único pesquisador. As respostas foram analisadas pelo programa Epi-Info. Os resultados mostraram que prevalece entre os acadêmicos o desejo de trabalhar no PSF por razões ligadas às dificuldades do mercado de trabalho e os mesmos citam freqüentemente a técnica como a principal característica necessária a um dentista para que o mesmo atue no PSF. Por outro lado, diferenças estatisticamente significativas foram encontradas entre os acadêmicos, apontando uma provável influência do Estágio Supervisionado, ministrado sob a forma de internato rural, sobre a formação do acadêmico da Faculdade 1, possivelmente habilitando-o melhor para o PSF. | Ciência & Saúde Coletiva | [
"Public Health, Environmental and Occupational Health",
"Health Policy"
] |
Boosting oxygen reduction catalysis with abundant copper single atom active sites | Single atomic copper doping in ultrathin nitrogenated carbon nanosheets over 20.9 wt% was achieved, greatly boosting the oxygen reduction catalysis. | Energy & Environmental Science | [
"Pollution",
"Nuclear Energy and Engineering",
"Renewable Energy, Sustainability and the Environment",
"Environmental Chemistry"
] |
Historical issues in Polish-Russian relations within the period of 1989 to 2007 | The article focuses on the issue of the influence of the historical conditions on the Polish-Russian relations at the turn of the 20th and 21st centuries. The history of these two countries is linked by a long-lasting and difficult past, and thus numerous unresolved disputes, burdens, and myths arose that have been felt to this day. In 1989, after the fall of the Communist system in our country, new political elites managing the process of democratic changes in the Third Polish Republic made efforts that aimed at settling disputed threads from the common Polish-Russian history. On the way to making up for the past, the period between 1989 and 2007 was marked by a number of important events that could be seen as the symbol of the common reconciliation. Unfortunately, there were also moments of regression and deep crisis that negatively affected the cooperation of both countries in the matter of dealing with difficult cards of the common history. This was influenced by a different approach to the past that is understood differently in Poland and in Russia and that contributed to the emergence of numerous misunderstandings, as well as to the mutual accusations in this field. | Rocznik Instytutu Europy Środkowo-Wschodniej | [
"Energy Engineering and Power Technology",
"Fuel Technology"
] |
Fluorescence imaging of intracellular telomerase activity for tumor cell identification by oligonucleotide-functionalized gold nanoparticles | An oligonucleotide-functionalized gold nanoparticle probe was developed and the high-efficiency detection of telomerase activity for cellular imaging toward the identification of tumors was realized. | [
"Electrochemistry",
"Spectroscopy",
"Environmental Chemistry",
"Biochemistry",
"Analytical Chemistry"
] | |
New Type of College Needed | [
"Education"
] | ||
Barbara | [
"Literature and Literary Theory",
"Visual Arts and Performing Arts",
"Cultural Studies"
] | ||
Vicarious C-amination of 1-methyl-4-nitroimidazole | [
"Organic Chemistry",
"Drug Discovery",
"Biochemistry"
] | ||
Analogies between SARS-CoV-2 infection dynamics and batch chemical reactor behavior | Chemical Engineering Science | [
"Applied Mathematics",
"Industrial and Manufacturing Engineering"
] | |
The role of filamentous CTXphi bacteriophage in Vibrio cholerae genetics and diversity | [
"Microbiology (medical)"
] | ||
Actualization of Religious Figures in Building a Culture of Peace in Plajan Pakis Aji Jepara | The lack of understanding of the culture of peace and the inadequate actualization of religious leaders (Islam, Christianity, and Hinduism) in Plajan Village, has resulted in the stagnation of a culture of peace that has been formed for a long time. Therefore, it is necessary to optimally actualize religious figures (Islam, Christianity, and Hinduism) in Plajan Village. This is because religious leaders are the key agents in fostering religious communities and as projections of the examples of religious adherents. To be stronger, it can also be added with innovation in the realm of peace management. Peace management is the answer to various challenges of division, conflict, and so on. Because peace management emphasizes intensive dialogue or interaction between religious leaders and religious communities. This research methodology uses qualitative research with a case study approach. Data collection techniques through observation and documentation methods. While the data analysis technique uses the Miles Huberman model, which consists of three stages, namely data reduction, data presentation, and drawing conclusions. | [
"Applied Mathematics"
] | |
Rational selection of the cation of an ionic liquid to control the reaction outcome of a substitution reaction | Rational selection of ionic liquids to get the rate constant you want in a substitution process. | [
"Materials Chemistry",
"Metals and Alloys",
"Surfaces, Coatings and Films",
"Ceramics and Composites",
"Electronic, Optical and Magnetic Materials",
"Catalysis"
] | |
RHIZOSTABILIZATION OF METALS IN SOILSUSING LUPINUS LUTEUSINOCULATED WITH THE METAL RESISTANT RHIZOBACTERIUMSERRATIASP. MSMC541 | [
"Plant Science",
"Pollution",
"Environmental Chemistry"
] | ||
Ueber die Aetheriflcirung einiger mehrbasischen Säuren | [
"Inorganic Chemistry"
] | ||
THE DEVELOPMENT AND ECONOMIC FUNCTION OF HOT SPRING RESORT SETTLEMENTS AT IKAHO AND KINUGAWA SPA | Geographical Review of Japan | [
"Geography, Planning and Development"
] | |
Good characterizations for some degree constrained subgraphs | [
"Computational Theory and Mathematics",
"Discrete Mathematics and Combinatorics",
"Theoretical Computer Science"
] | ||
Synthesis, characterization, and coordination chemistry of phosphines with ethylenedioxythiophene substituents | The preparation of several new phosphines bearing one or more 3,4-ethylenedioxythiophene (EDOT) units as substituents linked at the 2-thienyl position is described. The phosphines were prepared by reaction of lithiated EDOT intermediates with appropriate chlorophosphines to afford (3,4-ethylenedioxy-2-thienyl)diphenylphosphine (1), (bis(3,4-ethylenedioxy-2-thienyl)phenylphosphine (2), tris(3,4-ethylenedioxy-2-thienyl)phosphine (3), 2,5-bis(diphenylphosphino)-3,4-ethylenedioxythiophene (4), and 2-diphenylphosphino-5-mesitylthio-3,4-ethylenedioxythiophene (5). Molybdenum carbonyl complexes of compounds 13 were prepared by reaction of the phosphine ligands with cis-Mo(CO)4(pip)2. In all cases, spectroscopic evidence is fully consistent with the phosphines acting as monodentate, P-bound ligands. Electrochemical studies on the phosphines as well as their metal complexes indicate that the normal electrochemical redox robustness of the EDOT group is dramatically decreased by the presence of phosphine substituents: all compounds exhibited irreversible oxidation processes and no evidence of electropolymerization was observed for the phosphines bearing two or three EDOT groups. Key words: phosphines, thiophene, 3,4-ethylenedioxythiophene, EDOT, electrochemistry, coordination complexes. | [
"Organic Chemistry",
"Catalysis"
] | |
61: Lung sparing surgery for mesothelioma is a safe and effective modality in the treatment of malignant mesothelioma | [
"Cancer Research",
"Pulmonary and Respiratory Medicine",
"Oncology"
] | ||
A Comparison of Clinical Registry Versus Administrative Claims Data for Reporting of 30-Day Surgical Complications | [
"Surgery"
] | ||
A Comparison of Urban and Rural Students on Scholastic and Related Variables | The Journal of Social Psychology | [
"Social Psychology"
] | |
Landfill gas emission prediction using Voronoi diagrams and importance sampling | [
"Ecological Modeling",
"Environmental Engineering",
"Software"
] | ||
The Cannock Chase ironworks, 1590 | [
"History"
] | ||
Amorphous As2 S3 thin film waveguide with grating coupler | [
"Electrical and Electronic Engineering",
"Atomic and Molecular Physics, and Optics",
"Electronic, Optical and Magnetic Materials"
] | ||
MODELING THE LOAD ON RECEPTION FACILITIES | [
"Waste Management and Disposal",
"Water Science and Technology",
"Ecology"
] | ||
Local rectal portal hypertension in the absence of a patent superior rectal vein | Endoscopy | [
"Gastroenterology"
] | |
L’irradiation des aires ganglionnaires (sus-claviculaire et mammaire interne) augmente-t-elle la toxicité de la radiothérapie adjuvante mammaire ? | [
"Radiology, Nuclear Medicine and Imaging",
"Oncology"
] | ||
Involvement of GCMB in the transcriptional regulation of the human parathyroid hormone gene in a parathyroid-derived cell line PT-r | Bone | [
"Histology",
"Physiology",
"Endocrinology, Diabetes and Metabolism"
] | |
‘Tausi Feagaiga (Covenant Keeper): Impacting Health Care in an Island Nation | [
"Public Health, Environmental and Occupational Health"
] | ||
Education, competence and staffing standards set for unscheduled care | Emergency Nurse | [
"Emergency Nursing"
] | |
Identification of soil denitrification peak as nitrous oxide | [
"Environmental Chemistry"
] | ||
Modified Constraint-Induced Therapy in Chronic Stroke: Results of a Single-Blinded Randomized Controlled Trial | Background and Purpose This single-blinded randomized controlled trial compared the efficacy of a reimbursable, outpatient, modified constraint-induced therapy (mCIT) protocol (half-hour therapy sessions occurring 3 days per week in which subjects used the more affected arm combined with less affected arm restriction 5 days per week for 5 hours; both of these regimens were administered during a 10-week period) with that of a time-matched exercise program for the more affected arm or a no-treatment control regimen. Subjects Thirty-five subjects with chronic stroke participated in the study. Methods The Action Research Arm Test (ARAT), Fugl-Meyer Assessment of Motor Recovery After Stroke (FM), and Motor Activity Log (MAL) were administered to the subjects. Results After intervention, significant differences were observed on the ARAT and MAL Amount of Use and Quality of Movement scales, all in favor of the mCIT group. Discussion and Conclusion The data affirm previous findings suggesting that this reimbursable, outpatient protocol increases more affected arm use and function. Magnitude of changes was consistent with those reported in more intense protocols, such as constraint-induced therapy. | [
"Physical Therapy, Sports Therapy and Rehabilitation"
] | |
RICHMOND, MARY E. Social Diagnosis. Pp. 511. Price, $2.00. New York: Ruasell Sage Foundation, 1917 | [
"Sociology and Political Science"
] | ||
Imprints of late quaternary climatic and sea level changes on East and South Indian coast | [
"Earth and Planetary Sciences (miscellaneous)",
"Geotechnical Engineering and Engineering Geology",
"Environmental Science (miscellaneous)",
"Oceanography"
] | ||
Two‐step annealing of arsenic‐implanted 〈111〉 silicon | [
"Physics and Astronomy (miscellaneous)"
] | ||
The adult with chronic cough | [
"Immunology",
"Immunology and Allergy"
] | ||
The influence of tamoxifen on growth behavior and cell–cell adhesion in OSCC in vitro | Oral Oncology | [
"Cancer Research",
"Oncology",
"Oral Surgery"
] | |
Risk Factors for Domestic Minor Sex Trafficking in the United States | [
"Law",
"Nursing (miscellaneous)",
"Psychiatry and Mental Health",
"Psychiatric Mental Health",
"Pathology and Forensic Medicine",
"Issues, Ethics and Legal Aspects"
] | ||
Synthesis of the New Nucleoside 5'-Alpha-Iminophosphates Using Staudinger Reaction | [
"Industrial and Manufacturing Engineering",
"Polymers and Plastics",
"History",
"Business and International Management"
] | ||
Survey Sampling. | [
"Sociology and Political Science"
] | ||
BOSTON SOCIETY OF PSYCHIATRY AND NEUROLOGY | [
"Neurology (clinical)",
"Arts and Humanities (miscellaneous)"
] | ||
Urokinase Plasminogen Activator System–Targeted Delivery of Nanobins as a Novel Ovarian Cancer Therapy | Abstract The urokinase system is overexpressed in epithelial ovarian cancer cells and is expressed at low levels in normal cells. To develop a platform for intracellular and targeted delivery of therapeutics in ovarian cancer, we conjugated urokinase plasminogen activator (uPA) antibodies to liposomal nanobins. The arsenic trioxide–loaded nanobins had favorable physicochemical properties and the ability to bind specifically to uPA. Confocal microscopy showed that the uPA-targeted nanobins were internalized by ovarian cancer cells, whereas both inductively coupled plasma optical mass spectrometry (ICP-MS) and fluorescence-activated cell sorting (FACS) analyses confirmed more than four-fold higher uptake of targeted nanobins when compared with untargeted nanobins. In a coculture assay, the targeted nanobins showed efficient uptake in ovarian cancer cells but not in the normal primary omental mesothelial cells. Moreover, this uptake could be blocked by either downregulating uPA receptor expression in the ovarian cancer cells using short-hairpin RNA (shRNA) or by competition with free uPA or uPA antibody. In proof-of-concept experiments, mice bearing orthotopic ovarian tumors showed a greater reduction in tumor burden when treated with targeted nanobins than with untargeted nanobins (47% vs. 27%; P < 0.001). The targeted nanobins more effectively inhibited tumor cell growth both in vitro and in vivo compared with untargeted nanobins, inducing caspase-mediated apoptosis and impairing stem cell marker, aldehyde dehydrogenase-1A1 (ALDH1A1), expression. Ex vivo fluorescence imaging of tumors and organs corroborated these results, showing preferential localization of the targeted nanobins to the tumor. These findings suggest that uPA-targeted nanobins capable of specifically and efficiently delivering payloads to cancer cells could serve as the foundation for a new targeted cancer therapy using protease receptors. Mol Cancer Ther; 12(12); 2628–39. ©2013 AACR. | [
"Cancer Research",
"Oncology"
] | |
Subject index | [
"Pharmacology (medical)",
"Pharmacology"
] | ||
Current position of high-resolution MS for drug quantification in clinical & forensic toxicology | This paper reviews high-resolution MS approaches published from January 2011 until March 2014 for the quantification of drugs (of abuse) and/or their metabolites in biosamples using LC-MS with time-of-flight or Orbitrap™ mass analyzers. Corresponding approaches are discussed including sample preparation and mass spectral settings. The advantages and limitations of high-resolution MS for drug quantification, as well as the demand for a certain resolution or a specific mass accuracy are also explored. | [
"Medical Laboratory Technology",
"Clinical Biochemistry",
"Analytical Chemistry"
] | |
Evaporatively-driven Marangoni instabilities of volatile liquid films spreading on thermally conductive substrates | [
"Colloid and Surface Chemistry"
] | ||
Hilbert Spaces Unconditional Bases Consisting of Values of Entire Vector-Functions of Order 1/2 | [
"Applied Mathematics",
"Statistics and Probability"
] | ||
Front Matter | [
"Sociology and Political Science"
] | ||
Time to Empower People With Stroke | Journal of Neurologic Physical Therapy | [
"Neurology (clinical)",
"Rehabilitation",
"Physical Therapy, Sports Therapy and Rehabilitation"
] | |
Evaluating the educational value of simulation games: Learners’ perspective | [
"Education"
] | ||
Exsolution of Ca-clinopyroxene from orthopyroxene aided by deformation | [
"Geochemistry and Petrology"
] | ||
Fungal diversity associated with bamboo litter from Bambusetum of Rain Forest Research Institute, Northeast India | Kumar R, Tapwal A, Pandey S, Rishi R. 2013. Fungal diversity associated with bamboo litter from Bambusetum of Rain Forest Research Institute, Northeast India. Biodiversitas 14: 79-88. Fungi play an important role in leaf litter decomposition due to their ability to break down the lignocelluloses matrix, which other organisms are unable to digest. Diversity of bamboo leaf litter fungi from fallen leaves and undergoing active decomposition leaves in different season and different depth was carried out in 2009-10. Twenty four samples were collected from Bambusetum of Rain Forest Research Institute (RFRI),  Northeast India. The moist chamber, direct isolation and dilution plate methods were used to assess the diversity of fungal species. Fungi were cultivated on 3% malt extract agar and half strength potato dextrose agar. The litter was divided into freshly fallen senescent leaves (grade 1) and leaves already undergoing active decomposition (grade 2). Moist chamber incubation of the litter revealed 45 fungal taxa belonging to 22 genera. fungal taxa were found on grade I and 39 fungal taxa found on grade II litter. Although 24 fungal taxa were common to both grades, Differences were observed in percentage occurrence of fugal species between the two grades of litter. Periodic surveys were carried out to collect macrofungi. Young and matured carpophores of 16 macro fungi species were collected in different seasons. Out of these macrofungi, 3 species belongs to family Entolomataceae and Agaricacea, two species belongs to Tricholomataceae and Geoglossaceae one species belongs to each family Dacrymycetaceae, Pluteaceae, Coprinaceae, Marasmiaceae Lycoperdaceae and Phallaceae. The bamboo leaf-litter was selected for the present syudy because of the dominance and great economic value of bamboo vegetation in North-east India. | [
"Plant Science",
"Molecular Biology",
"Animal Science and Zoology"
] | |
Change in clinician-assessed measures of multiple sclerosis and subject-reported quality of life: results from the IMPACT study | Background The IMPACT study demonstrated the benefit of interferon beta-1a (IFNβ-1a, Avonex®) two-year change in disability measured by the Multiple Sclerosis Functional Composite (MSFC) in secondary progressive multiple sclerosis (SP-MS) and health-related quality of life (HRQoL) measured by the Multiple Sclerosis Quality of Life Inventory (MSQLI). The IMPACT data permit a detailed assessment of the relation between clinical and self-reported measures. Methods IMPACT was an international randomized, double-blind, placebo-controlled trial of SP-MS patients. As the MSQLI is only in English, this report includes US and Canadian subjects. Subjects were randomized to weekly intramuscular (im) injections of INb-1a (60 mg) or placebo for 24 months. Results At baseline and follow-up, MSQLI correlations were generally stronger with the EDSS than with the MSQLI, MSFC but comparable with MSFC components. Combining the two groups, MSQLI changes for those in the best and worst MSFC change quartiles demonstrated a statistical difference for six of the 11 MSQLI scales. Linear regression demonstrated that EDSS change from baseline to month-24 scores was correlated with change in two MSQLI components. Conclusion These data support the appropriateness of using the MSQLI with individuals who have SP-MS. | Multiple Sclerosis Journal | [
"Neurology (clinical)",
"Neurology"
] |
Long-term effects of neonatal seizures: a behavioral, electrophysiological, and histological study | [
"Developmental Biology",
"Developmental Neuroscience"
] | ||
Aborder la RSE avec des partenariats entreprises-associations | Cet article analyse la contribution des partenariats entreprises-associations pour amorcer une démarche de responsabilité sociale d’entreprise. Les auteurs montrent notamment comment le fonctionnement des partenariats constitue une modularisation de leur complexité intrinsèque, ainsi que de celle de la RSE. Cette approche permet d’identifier de bonnes pratiques, dans le but de concrétiser une telle démarche au niveau organisationnel et de nourrir le projet RSE au niveau global. | [
"Strategy and Management",
"Economics and Econometrics",
"Business and International Management"
] | |
The Origin of Amebocytes in Biomphalaria glabrata | [
"Ecology, Evolution, Behavior and Systematics",
"Parasitology"
] | ||
Cosmic Baryon Asymmetry in Different Neutrino Mass Models with Mixing Angles | We investigate the comparative studies of cosmological baryon asymmetry in different neutrino mass models with and withoutθ13by considering the three-diagonal form of Dirac neutrino mass matrices and the three aspects of leptogenesis, unflavoured, flavoured, and nonthermal. We found that the estimations of any models withθ13are consistent in all the three stages of calculations of leptogenesis and the results are better than the predictions of any models withoutθ13which are consistent in a piecemeal manner with the observational data in all the three stages of leptogenesis calculations. For the normal hierarchy of Type-IA with charged lepton matrix, model with and withoutθ13predicts inflaton mass required to produce the observed baryon asymmetry to beMϕ~2.2×1011 GeV andMϕ~3.6×1010 GeV, and the corresponding reheating temperatures areTR~4.86×106 GeV andTR~4.50×106 GeV respectively. These predictions are not in conflict with the gravitino problem which required the reheating temperature to be below107 GeV. And these values apply to the recent discovery of Higgs boson of mass~125 GeV. One can also have the right order of relic dark matter abundance only if the reheating temperature is bounded to below107 GeV. | [
"Nuclear and High Energy Physics"
] | |
Weierstrass functions in Zygmund’s class | Proceedings of the American Mathematical Society | [
"Applied Mathematics"
] | |
Developmental Responses of Tobacco Plants under Constant and Artificial Alternating Temperature Conditions. | [
"Genetics",
"Agronomy and Crop Science",
"Food Science"
] | ||
Relevance of feeding ecology in the management of invasive species: Prey variability in a novel invasive crab | Estuarine, Coastal and Shelf Science | [
"Aquatic Science",
"Oceanography"
] | |
Pharmaceutical Research | [
"Pharmacology (medical)",
"Organic Chemistry",
"Pharmaceutical Science",
"Pharmacology",
"Molecular Medicine",
"Biotechnology"
] | ||
All-optical switching of silicon disk resonator based on photothermal effect in metal–insulator–metal absorber | [
"Atomic and Molecular Physics, and Optics"
] | ||
Oxford medial unicompartmental knee arthroplasty in patients younger and older than 60 years of age | We present a comparison of the results of the Oxford unicompartmental knee arthroplasty in patients younger and older than 60 years of age. The ten-year all-cause survival of the | [
"Orthopedics and Sports Medicine",
"Surgery"
] | |
CT manifestations of peritoneal leiomyosarcomatosis. | [
"Radiology, Nuclear Medicine and Imaging"
] | ||
An Inversion Theorem-Based Kernel Density Estimator for a Weighted Average and Difference of Weighted Averages with Applications | [
"Statistics and Probability"
] | ||
Multiple heterotope Hodenentwicklung beim Schwein | [
"Cell Biology",
"Molecular Biology",
"Pathology and Forensic Medicine"
] | ||
NAVIGATION | [
"Atmospheric Science"
] | ||
Dowsing | [
"Library and Information Sciences",
"Literature and Literary Theory",
"Linguistics and Language",
"Language and Linguistics"
] | ||
Bcl2, a transcriptional target of p38α, is critical for neuronal commitment of mouse embryonic stem cells | Cell Death & Differentiation | [
"Cell Biology",
"Molecular Biology"
] | |
P53 Menorrhagia in adolescents with inherited bleeding disorders | [
"Hematology"
] | ||
Safety of self-expandable metal stents (SEMS) or emergency surgery for acute malignant colonic obstruction in patients treated with bevacizumab. | [
"Cancer Research",
"Oncology"
] | ||
A Note on the Orlik–Solomon Algebra | European Journal of Combinatorics | [
"Discrete Mathematics and Combinatorics"
] | |
Scale-up of immunoaffinity separation processes | [
"Applied Microbiology and Biotechnology",
"Biotechnology",
"Bioengineering"
] | ||
High-order approximation of wave propagation constants in a uniformly curved waveguide | [
"Electrical and Electronic Engineering",
"Computer Networks and Communications"
] | ||
Old and New Horns of the Prong-Horned Antelope | [
"Nature and Landscape Conservation",
"Genetics",
"Animal Science and Zoology",
"Ecology",
"Ecology, Evolution, Behavior and Systematics"
] | ||
The impact of the implementation of the antimicrobial stewardship program in a victorian regional hospital | [
"Infectious Diseases",
"Public Health, Environmental and Occupational Health"
] | ||
Abstract P2-09-26: Circadian Clock Genes in Primary Breast Cancer: Strong Predictors of Pathologic Response on Neoadjuvant Chemotherapy | Abstract Background: Circadian clocks involve 15 specific genes, which control cell cycle, apoptosis, DNA repair and metabolism. Circadian disruption is associated with both an increased risk of breast cancer, and poor survival in patients (pts) with metastatic cancer (IARC#98; Innominato et al. Cancer Res 2009). Objective: to provide first evidence of clinical relevance of clock genes expression for the therapeutic sensitivity of primary breast cancer. Method: Affymetrix Hgu133plus2 microarrays data were derived from 189 primary breast cancers. All the pts had non metastatic disease and were registered in multicenter Phase II trial of neoadjuvant chemotherapy with epirubicin-cyclophosphamide (4 courses) then docetaxel ± herceptin (4 courses). In this study, negative hormonal receptor status and limited tumor size predicted for pathological complete response rate (pCR) (Pierga JY, et al Breast Cancer Res Treat. 2010).The expression data of 15 core clock genes, within the whole tumor transcriptome, were related both to tumor mitotic index (MI) and estrogen receptors (ESR1), and to chemotherapy-induced pCR. Statistical validation involved T-test statistics, with corrections for multiple testing. Results: In the tumor biopsy obtained before treatment onset, both Per2 and Cry2 expressions correlated positively with ESR1 (r≥0.43; P<0.001) and inversely with (MI (r≤−0.28; P<0.007). In addition, a positive correlation was found for Dec 1 with ESR1 (r=0.65, P<0.001). The mean expressions of Per2, Cry2 and Dec 1 before chemotherapy were lower in the 32 pts who subsequently achieved pathologic complete response (pCR) as compared to the 157 who did not (P<0.001). No other clock gene expression was significantly related to pCR. The odds ratio confirmed the decreased chance of achieving pCR with increased expression of clock genes Per2, Cry2 or Dec1. Clock gene expression and pCR Conclusion: Low expressions of three core genes in the negative loop of the molecular circadian clock strongly predicted for the induction of a pathologic complete response of primary breast cancer with neoadjuvant chemotherapy. While circadian clock disruption seems to constitute a poor prognostic factor in cancer patients, our data suggest that the downregulation of core circadian genes in tumors significantly enhances susceptibility to chemotherapy. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P2-09-26. | Cancer Research | [
"Cancer Research",
"Oncology"
] |
Predictive temperature tracking for batch evaporative crystallizers: the partial state model reference approach | Journal of Process Control | [
"Industrial and Manufacturing Engineering",
"Computer Science Applications",
"Modeling and Simulation",
"Control and Systems Engineering"
] | |
Islamic Education and Islamization: Evolution of Themes, Continuities and New Directions | [
"Political Science and International Relations",
"Sociology and Political Science",
"Anthropology",
"Cultural Studies"
] | ||
";“Characteristics of cognitive evaluation in transplanted liver patients in a tertiary care hospital";” | [
"Neurology (clinical)",
"Neurology"
] | ||
Virus-Isolierung aus kranken Larven vonHibernia defoliaria L. undEuproctis chrysorrhoea L. | [
"Ecology, Evolution, Behavior and Systematics"
] | ||
Luck, AM, 2004-2009 | [
"Computer Science Applications",
"History",
"Education"
] | ||
954. Demonstration of In Vivo Off-Targeting Using rAAV-Delivered Ribozymes and shRNA Molecules in a Mouse Model of Huntington's Disease | [
"Drug Discovery",
"Pharmacology",
"Genetics",
"Molecular Biology",
"Molecular Medicine"
] | ||
Research on spectral reflectance reconstruction based on compressive sensing by a gradual modulation wheel | Journal of Optical Technology | [
"Applied Mathematics",
"Computational Mathematics",
"Atomic and Molecular Physics, and Optics"
] | |
Determination of triglycerides with special emphasis on biosensors: A review | [
"Molecular Biology",
"Biochemistry",
"Structural Biology"
] | ||
Oerative treatment of the plantar-flexed inverted foot in adult hemiplegia | The Journal of Bone & Joint Surgery | [
"Orthopedics and Sports Medicine",
"Surgery"
] | |
Adenocarcinoma of the ethmoid following radiotherapy for bilateral retinoblastoma | The Laryngoscope | [
"Otorhinolaryngology"
] | |
Plurality Voting and the Computation of the Average Duration of Frames of Parallel Mutual Exclusion Accesses | [
"Applied Mathematics",
"Computational Theory and Mathematics",
"Computer Science Applications",
"Numerical Analysis",
"Analysis"
] | ||
Religionsunterricht in Ostdeutschland. Zu alten und neuen Herausforderungen | Abstract Religious education in East Germany is religious education in the plural. Different models stand side by side. Acceptance and structural anchoring in the individual school types also vary. Nevertheless, unifying challenges can be identified that need to be addressed. They make it clear that there is a need for a further development or readjustment of the models of religious instruction that on the one hand satisfies the positionality of religiosity, which is so important from the point of view of religious didactics, and on the other hand is capable of absorbing religious diversity and secularity on the part of students inside. | [
"Religious Studies"
] | |
Rapid Optimization of a Peptide Inhibitor of Malaria Parasite Invasion by Comprehensive N-Methyl Scanning | [
"Cell Biology",
"Molecular Biology",
"Biochemistry"
] | ||
High-Temperature Testing of the Properties of Blast Furnace Coke | The article describes the behaviour of coke in the blast furnace. Factors, which cause weakening and degradation of coke lumps at temperatures above 1300°C have been analyzed. On the basis of preliminary testing of samples taken from a blast furnace at different distances from the tuyère outlet and tests for thermo-abrasion ξ, the advisability of using the pre-tuyère chamber for the assessment of coke quality at high temperatures has been indicated. Thermodynamic calculations for the determination of the chemical composition of the products of reaction of coke ash mineral substances with elementary carbon and air, as well as the behaviour of coke at high temperatures under inert gas conditions are presented. The number of compounds forming from coke ash components during heating in a stream of gases of highly differential reductiveness reflects the complexity of the physicochemical phenomena. | [
"Mechanical Engineering",
"Mechanics of Materials",
"Condensed Matter Physics"
] | |
An experiment of stress buildup and relaxation in the flow of viscoelastic polymer melts | Rheologica Acta | [
"Condensed Matter Physics"
] | |
Book Review: Economics | [
"Education"
] | ||
Radiation-assisted chemical short-range order formation in high-entropy alloys | Scripta Materialia | [
"Condensed Matter Physics",
"Mechanics of Materials",
"Metals and Alloys",
"Mechanical Engineering"
] |
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