Title stringlengths 0 905 | Abstract stringlengths 0 11.3k | Container_Title stringlengths 0 126 | Subject listlengths 1 13 |
|---|---|---|---|
Toxicant-associated Steatohepatitis | Hepatotoxicity is the most common organ injury due to occupational and environmental exposures to industrial chemicals. A wide range of liver pathologies ranging from necrosis to cancer have been observed following chemical exposures both in humans and in animal models. Toxicant-associated fatty liver disease (TAFLD) is a recently named form of liver injury pathologically similar to alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD). Toxicant-associated steatohepatitis (TASH) is a more severe form of TAFLD characterized by hepatic steatosis, inflammatory infiltrate, and in some cases, fibrosis. While subjects with TASH have exposures to industrial chemicals, such as vinyl chloride, they do not have traditional risk factors for fatty liver such as significant alcohol consumption or obesity. Conventional biomarkers of hepatotoxicity including serum alanine aminotransferase activity may be normal in TASH, making screening problematic. This article examines selected chemical exposures associated with TAFLD in human subjects or animal models and concisely reviews the closely related NAFLD and ALD. | [
"Cell Biology",
"Toxicology",
"Molecular Biology",
"Pathology and Forensic Medicine"
] | |
The anterolateral complex in anterior cruciate ligament deficient knees demonstrate sonographic abnormalities on high-resolution sonography | [
"Orthopedics and Sports Medicine",
"Surgery"
] | ||
Encephalopathy induced by oral hypoglycemic drugs | [
"Critical Care and Intensive Care Medicine"
] | ||
The Impact of MYC Rearrangements and “Double Hit” Abnormalities in Diffuse Large B-Cell Lymphoma | [
"Cancer Research",
"Oncology",
"Hematology"
] | ||
New York Obstetrical Society | American Journal of Obstetrics and Gynecology | [
"Obstetrics and Gynecology"
] | |
Yield behavior and energy absorbing characteristics of rubber-modified epoxies subjected to biaxial stress states | Polymer Composites | [
"Materials Chemistry",
"Polymers and Plastics",
"Ceramics and Composites"
] | |
Cytology and Cellular Pathology of the Nervous System. | [
"Neurology (clinical)",
"Arts and Humanities (miscellaneous)"
] | ||
Easy access to drug information derwent information and ovid technologies Inc | [
"Biochemistry",
"Analytical Chemistry"
] | ||
Role of Mg and Ti on a SiCp,ZrCp/Al composite at elevated temperatures | [
"Mechanical Engineering",
"Mechanics of Materials"
] | ||
Situation économiques des chemins de fer argentins | Revue de Métallurgie | [
"Materials Chemistry",
"Metals and Alloys",
"Physical and Theoretical Chemistry",
"Condensed Matter Physics"
] | |
: Government by Constitution: The Political Systems of Democracy . Herbert J. Spiro. | [
"Arts and Humanities (miscellaneous)",
"Anthropology"
] | ||
2-[(4-Bromo-2,3-dioxobutyl)thio]adenosine 5'-monophosphate, a new nucleotide analog that acts as an affinity label of pyruvate kinase | [
"Biochemistry"
] | ||
Floodplains and Connectivity Zones: Enhancing the Provision of Ecosystem Services | Water Resources Management | [
"Water Science and Technology",
"Civil and Structural Engineering"
] | |
Activation of Macrophages by Lipopolysaccharide for Assessing the Immunomodulatory Property of Biomaterials | [
"Biomedical Engineering",
"Biomaterials",
"Biochemistry",
"Bioengineering"
] | ||
Momentum Budgets of a Subtropical Squall Line Determined from Dual-Doppler Data | [
"Earth and Planetary Sciences (miscellaneous)",
"Atmospheric Science",
"Oceanography"
] | ||
Parallel Changes in Positive Youth Development and Self-awareness: the Role of Emotional Self-regulation, Self-esteem, and Self-reflection | AbstractThe aim of the present study was to examine whether early adolescents’ positive development (i.e., resilience and psychological wellbeing) could be enhanced by stimulating three dimensions of self-awareness: emotional self-regulation, self-esteem, and self-reflection. An experimental field study (randomized controlled trial) was conducted. Seventh grade students (N = 1299; Mage = 12.38; 54% boys) completed multiple assessments at the beginning, during, and immediately after the intervention or at parallel time points for students in the control condition. Changes in the assessed constructs were examined with parallel process latent growth curve models. The results showed that increases in emotional self-regulation and self-esteem were related to concurrent increases in both resilience and psychological wellbeing. Changes in self-reflection were, however, not related to changes in these outcomes. The trajectories of change and parallel processes were similar in the intervention and control condition. These findings suggest that interventions aiming to stimulate positive youth development might be optimized by also focusing on youth’s self-awareness, though more knowledge about how self-awareness can be stimulated best is needed. This trial was registered in the Dutch Trial Register, number NL6371 (old number: NTR6554), on July 3, 2017. | [
"Public Health, Environmental and Occupational Health"
] | |
Overview and Improvement of Procedures and Practices of Electricity Transmission System Operators in South East Europe to Mitigate Cybersecurity Threats | The implementation of information and communication technologies (ICT) in power systems increases the risks of cybersecurity threats, requiring protection measures that should reflect the multi-actor environment of the contemporary power systems. This paper provides a critical assessment of the cybersecurity practices of the transmission system operators (TSOs) from South East Europe (SEE) and the implementation of obligations for TSOs emerging from the complex set of cybersecurity and electricity legislation. The analyses of TSO cybersecurity practices are based on a survey conducted with the TSOs from SEE and show there is a lack of consistent cybersecurity policy at the TSO level. These analyses demonstrate that the differences between TSOs from the SEE region are not very significant with regards to implementation of technical protection and defense measures for critical infrastructures (CIs) and assets. The comprehensive analyses of electricity and cybersecurity legislation uncover the obligations of TSOs emerging from legislation and relate them to current TSO cybersecurity practices, confirming the necessity to boost existing practices. Considering the analyzed legislation and implemented practices, this paper presents a proposal for a cybersecurity framework for TSOs that should improve their organizational and operational response to the evolving cybersecurity challenges. | Systems | [
"Information Systems and Management",
"Computer Networks and Communications",
"Modeling and Simulation",
"Control and Systems Engineering",
"Software"
] |
When does it pay to invest in pricing algorithms? | Production and Operations Management | [
"Management of Technology and Innovation",
"Industrial and Manufacturing Engineering",
"Management Science and Operations Research"
] | |
Hypoxia alters testicular functions of marine medaka through microRNAs regulation | [
"Health, Toxicology and Mutagenesis",
"Aquatic Science"
] | ||
Late Cretaceous–early Paleocene ostracod biostratigraphy of Scientific Drilling Sk1(N) in the Songliao Basin, northeast China | Cretaceous non-marine deposits are widespread in China and have been studied comprehensively. The Songliao Basin in northeast China is thought to be well suited for investigation of Cretaceous biostratigraphy. However, despite much research having been conducted in the basin, little is known about its Late Cretaceous biostratigraphy and paleoenvironment. Here, we establish a high-resolution biostratigraphy of the Late Cretaceous based on ostracods from borehole SK1(n) in the Songliao Basin, northeast China. As part of the present study, 45 species assigned to 20 genera have been recovered, with one new species (Ilyocypris bisulcatan. sp.) and five ostracod assemblages: theCypridea gunsulinensis–Mongolocypris magnaassemblage, which is marked by the first occurrence (F.O.) ofIlyocyprimorphawith nodes and spines; theIlyocyprimorpha–Limnocypridea sunliaonensis–Periacanthellaassemblage, which ranges from the F.O. ofIlyocyprimorphawith nodes and spines to the F.O. ofStrumosiasp.; theStrumosia inanditaassemblage from the F.O. ofStrumosiasp. to the lower occurrence (L.O.) ofStrumosia inandita; theTalicypridea amoena–Metacypris kaitunensis–Ziziphocypris simakoviassemblage from the F.O. ofMongolocypris apiculata(Cea) andTalicypridea amoenato the F.O. ofIlyocyprissp.; and theIlyocyprisassemblage from the F.O. ofIlyocyprissp. to the L.O. ofIlyocypris bisulcatan. sp.Moreover, the zonal fossilIlyocypris bisulcatan. sp. of Zone 5 is here described for the first time from the upper Mingshui Formation, and Paleocene charophyte genera includingNeocharaandGrovesicahrahave been found to coexist with the Zone 5 fauna. The age of theIlyocyprisAssemblage is assigned to the latest Maastrichtian to the earliest Danian. | [
"Paleontology"
] | |
Change Strategies and Associated Implementation Challenges: An Analysis of Online Counselling Sessions | [
"Sociology and Political Science"
] | ||
Studies of stereotypy function in the canary (Serinus canarius) | Animal Behaviour | [
"Animal Science and Zoology",
"Ecology, Evolution, Behavior and Systematics"
] | |
Spectrophotometric study of charge transfer complex between 2,6-diaminopyridine and 2,5-dihydroxy-p-benzoquinone | [
"Materials Chemistry",
"Physical and Theoretical Chemistry",
"Condensed Matter Physics",
"Electronic, Optical and Magnetic Materials"
] | ||
Reflections on the ebola public health emergency of international concern, Part 1: Post-Ebola syndrome: The silent outbreak | [
"Infectious Diseases"
] | ||
The White House as a Black Box: Oral History and the Problem of Evidence in Presidential Studies | Scholars who study the American presidency usually have to rely on indirect evidence for understanding the internal operations of the ‘black box’ that is a contemporaneous White House. Most of the direct evidence about White House behavior becomes available only after a president has left office, when confidential communications are opened to the public by the presidential libraries. In recent years, however, such direct evidence has become increasingly inaccessible, because of changes in the record-keeping habits of senior executive branch officials and because of the politics of archival release. This article explores the nature and extent of these problems, and how elite oral history interviewing can compensate for them. It further examines the strengths and weaknesses of oral history as a means of learning about the usually hidden workings of the American presidency. | Political Studies | [
"Sociology and Political Science"
] |
Derivation of equations of motion for the magnetization of an antiferromagnet | [
"Mathematical Physics",
"Statistical and Nonlinear Physics"
] | ||
Genetic algorithms and artificial neural networks for loading pattern optimisation of advanced gas-cooled reactors | Annals of Nuclear Energy | [
"Nuclear Energy and Engineering"
] | |
A new adhesion barrier for myomectomy: The shelhigh dome pericardial no-react treated patch | [
"Obstetrics and Gynecology"
] | ||
Probing the dynamics of perisaccadic perception with EEG | Journal of Vision | [
"Sensory Systems",
"Ophthalmology"
] | |
Ghrelin suppression is associated with weight loss and insulin action following gastric bypass surgery at 12 months in obese adults with type 2 diabetes | [
"Endocrinology",
"Endocrinology, Diabetes and Metabolism",
"Internal Medicine"
] | ||
Generic Decision Support Model for Determining the Best Marketer | [
"Management of Technology and Innovation",
"Physics and Astronomy (miscellaneous)",
"Engineering (miscellaneous)"
] | ||
Improving Pediatric Breast Ultrasound Reporting and Recommendations | [
"Radiology, Nuclear Medicine and Imaging"
] | ||
Exact train pathing | Journal of Scheduling | [
"Artificial Intelligence",
"Management Science and Operations Research",
"Software"
] | |
Cumulative Incidence of Cytomegalovirus Infection and Disease After Heart Transplantation in the Last Decade: Effect of Preemptive Therapy | [
"Transplantation",
"Surgery"
] | ||
VITRECTOMY RESULTS FOR RHEGMATOGENOUS RETINAL DETACHMENT WITH CONCOMITANT MACULAR HOLE IN NONMYOPIC PATIENTS | [
"Ophthalmology"
] | ||
Issue Information | [
"Industrial Relations"
] | ||
Integral representations of the schrödinger propagator | [
"Mathematical Physics",
"Statistical and Nonlinear Physics"
] | ||
Existence of Lévy's area and pathwise integration | [
"Statistics and Probability"
] | ||
Should Health Care Professionals Google Patients or Family Members? | [
"Neurology (clinical)",
"Neurology",
"Rehabilitation",
"Physical Therapy, Sports Therapy and Rehabilitation"
] | ||
Comment | Biometric Technology Today | [
"Electrical and Electronic Engineering"
] | |
Can Quantifiable Bone Scans Help Guide Timing of Surgery in Skeletal Class III Patients? | Journal of Oral and Maxillofacial Surgery | [
"Otorhinolaryngology",
"Oral Surgery",
"Surgery"
] | |
Teaching of Military Medicine | [
"Education"
] | ||
Does the Brief Symptom Inventory-18 Case Rule Apply in Adult Survivors of Childhood Cancer?: Comparison With the Symptom Checklist-90 | [
"Developmental and Educational Psychology",
"Pediatrics, Perinatology and Child Health"
] | ||
Acoustical research in the physical sciences: Superconductivity and superfluidity | [
"Acoustics and Ultrasonics",
"Arts and Humanities (miscellaneous)"
] | ||
IEEE Feedback | [
"Electrical and Electronic Engineering",
"Industrial and Manufacturing Engineering",
"Energy Engineering and Power Technology",
"Control and Systems Engineering"
] | ||
Coupling molecular and risk analysis to investigate the origin, distribution and potential impact of non-native species: an application to ruffe Gymnocephalus cernua in Turkey | The European Zoological Journal | [
"Animal Science and Zoology"
] | |
Some issues associated with the intermediate space in single-crystal plasticity | [
"Mechanical Engineering",
"Mechanics of Materials",
"Condensed Matter Physics"
] | ||
Preoperative use of testosterone propionate as an aid to surgical treatment of endometriosis | [
"Obstetrics and Gynecology"
] | ||
Maurice Merleau-Ponty: Between Phenomenology and Structuralism | [
"Museology",
"Archeology",
"History"
] | ||
KAJIAN KES TAN SRI ABDUL KHALID IBRAHIM LWN BANK ISLAM (M) BERHAD MENGENAI ISU PENENTUAN KEPUTUSAN OLEH MAHKAMAH ATAU MAJLIS PENASIHAT SHARIAH DALAM HAL-HAL KEWANGAN DAN PERBANKAN ISLAM | Majlis Penasihat Shariah (SAC) telah ditubuhkan di bawah Bank Negara Malaysia bagi tujuan menyelaras prinsip-prinsip Islam di dalam isu-isu kewangan dan merupakan badan rujukan utama di dalam kes-kes berkaitan kewangan Islam di dalam negara. Walaubagaimanapun, pindaan Akta Bank Negara Malaysia 2009 telah memberi kesan kepada keputusan SAC berkaitan isu kewangan Islam apabila SAC dapat mengikat mahkamah sivil untuk mengikutnya di dalam keputusan sesuatu kes. Berikutan masalah ini, kuasa SAC telah dilihat bertentangan dengan semangat perlembagaan melalui hak kesamarataan dan hak mahkamah untuk membuat keputusan tanpa terikat dengan mana-mana badan. Pindaan yang dibuat di dalam Akta Bank Negara Malaysia 2009 melalui beberapa peruntukan juga dianggap sebagai bertentangan dengan perlembagaan (unconstitutional). Kertas kerja ini akan menggunakan kaedah kajian perbandingan (comparative study) yang melibatkan perbandingan beberapa akta dan peruntukan undang-undang serta perlembagaan persekutuan. Kertas kerja ini juga mencadangkan agar kedudukan SAC diperkemaskan melalui kewujudan akta baru iaitu Akta Perkhidmatan Kewangan Islam 2013 (IFSA) dan peranan SAC dapat diperkukuhkan demi kemaslahatan perbankan dan kewangan Islam. Kata kunci: Majlis Penasihat Shariah (SAC), Institusi Perbankan dan Kewangan Islam, Bank Negara Malaysia, Undang-Undang Perlembagaan | UUM Journal of Legal Studies | [
"Law",
"Sociology and Political Science"
] |
Die Bedeutung der Natriumretention in der Physiologie des Frühgeborenen und in der Pathologie des Säuglings | Acta Paediatrica | [
"Pediatrics, Perinatology and Child Health"
] | |
Price: £176PD Hoeprich, MC Jordan and AR Ronald, Infectious Diseases —A Treatise of Infectious Processes, J. B. Lipincott Company, Philadelphia (1996) ISBN 0-397-51296-1, p. 1532 pages. | [
"Infectious Diseases",
"Microbiology (medical)"
] | ||
Zur Physiologie von Sportbewegungen | [
"Physiology (medical)",
"Public Health, Environmental and Occupational Health",
"Orthopedics and Sports Medicine",
"Physiology"
] | ||
Defining fallopian tube‐derived miRNA cancer signatures | [
"Cancer Research",
"Radiology, Nuclear Medicine and Imaging",
"Oncology"
] | ||
Radial Oscillations of the Generalized Roche Model. | [
"Space and Planetary Science",
"Astronomy and Astrophysics"
] | ||
Perinatal and childhood risk factors for overweight in a provincial sample of Canadian Grade 5 students | [
"Public Health, Environmental and Occupational Health",
"Nutrition and Dietetics",
"Health Policy",
"Pediatrics, Perinatology and Child Health"
] | ||
CpG hypermethylation of the promoter region inactivates the estrogen receptor-? gene in patients with prostate carcinoma | [
"Cancer Research",
"Oncology"
] | ||
Mesozoic structural and metamorphic history of the central Ruby Mountains metamorphic core complex, Nevada | [
"Geology"
] | ||
Signal Transduction Pathways That Regulate Eukaryotic Protein Synthesis | [
"Cell Biology",
"Molecular Biology",
"Biochemistry"
] | ||
Abdelwahab Elmessiri’s Islamic humanism | Abdelwahab Elmessiri’s intellectual journey narrates the story of modern ideologies that have led to the marginalization of divine revelation, giving rise to materialistic worldviews that promise their adherents progress, happiness, and freedom. Elmessiri, however, introduced a critical sociology that underlines the dark side of modernity, stressing that modernity has transformed humankind into a bundle of biological functions, economic needs, contractual relationships, instincts, and sexual drives. The end of utopian ideologies and the rise of globalization have radicalized the situation, which Elmessiri refers to as ‘comprehensive secularism.’ Against this background, Elmessiri experienced many moments of illumination, culminating in his advocacy of an ‘Islamic humanism’ that sees human life as complex phenomenon permeated with secrets, dualities, and diversities. This review, however, argues that Elmessiri’s Islamic humanism is ironically based on humanist Marxism and Western critical sociology. | International Sociology | [
"Sociology and Political Science"
] |
Molecular Microbiology | [
"Molecular Biology",
"Microbiology"
] | ||
Tissue culture and the use of transgenic plants to study plant development | [
"Plant Science",
"Biotechnology"
] | ||
Plant Production in Relation to Foliage Illumination | Annals of Botany | [
"Plant Science"
] | |
Photooxidation with Rose Bengal of a Critical Histidine Residue in Yeast Enolase* | Biochemistry | [
"Biochemistry"
] | |
Decorative supplements and their role in fabric designs and women's fashion | The decorative supplements added are important factors in determining many decorative effects and how to implement them, whether in fabrics or fashion, and also work to determine the nature of perception for both the designer and the recipient and have a key role in shaping the human personality and determining his motives and emotional tendencies in the acquisition of fabrics and fashion and the vocabulary they carry A design that has certain connotations and symbols that gain its value from the effects it leaves on the physical formations of women. The problem of the research came with the following question (What are the decorative supplements and their role in the designs of fabrics and women’s fashion?) The research also dealt with three sections, the first topic included the methodological framework in posing the problem and its importance and objectives as well as On the definition of the most important terms, and the second topic included the theoretical framework, which included the following topics: First: The concept of decorative complements in design, Second: Decorative designs in fabrics and fashion. As for the third topic, it included the research procedures to reach the objectives of the research, and it relied on the analytical description method, and then the most important results and recommendations were included, and finally the most important sources and references.1. The design models relied on industrial raw materials in the first place because of their good appearance, high ironing ability, flexibility, softness, and high ability to accept dyeing and printing techniques, which helped in showing the aesthetic aspects that are consistent with the design goal and the age stage.2. The printing technology has played a clear role in highlighting the aesthetic qualities of the decorative designs through the optical values. These values have achieved the variation in the percentage of appearance and how to influence the nature of the recipient's perception of it, which made the technology an active role in determining the nature of the decorative supplements added and the method of influencing the recipient. | [
"Automotive Engineering"
] | |
Facilitators and barriers to optimal preventive service use among providers and older patients | Geriatric Nursing | [
"Gerontology"
] | |
Survival nomogram for endometrial cancer with lung metastasis: A SEER database analysis | PurposeThe lung is the most common distant metastatic organ in patients with endometrial cancer (EC) but is rarely reported. This study examines the association between clinical characteristics and overall survival (OS) in EC with lung metastasis.MethodsPatients with EC who had accompanying lung metastasis were selected from the Surveillance, Epidemiology, and End Results (SEER) database between 2010 and 2017. Univariate and multivariate Cox regression were used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) and assess OS outcomes related to EC with lung metastasis. A Cox proportional hazards nomogram model for OS was constructed and validated. The calibration plot, receiver operating characteristic (ROC) curve and decision curve analysis (DCA) were used to evaluate the discriminative ability and clinical benefit of the novel nomogram. Kaplan–Meier curves and scatter diagram analysis were used to investigate the risk stratifications of the nomogram.ResultsOverall, 1542 EC patients with lung metastasis between 2010 and 2017 were included and randomly divided into training and validation cohorts. A nomogram model was constructed using the clinical characteristics of tumor grade, histological type, surgery, adjuvant chemotherapy, adjuvant radiation, brain metastasis and liver metastasis. The concordance indexes (C-indexes) were 0.750 (95% CI, 0.732-0.767) and 0.743 (95% CI, 0.719-0.767) for the training cohort and validation cohort, respectively. Calibration plots and DCA showed good clinical applicability of the nomogram. The areas under the curves (AUCs) were 0.803 and 0.766 for 1-year and 3-year OS, respectively, indicating that the nomogram model had a stable discriminative ability. An online calculator of our nomogram is available on the internet at https://endometrialcancer.shinyapps.io/DynNomapp/. Additionally, patients in the high-risk group had a significantly worse OS than those in the low-risk group.ConclusionAn easy-to-use, highly accurate nomogram was developed for predicting the prognosis of EC patients with lung metastasis. | [
"Cancer Research",
"Oncology"
] | |
Table of contents | [
"Electrical and Electronic Engineering",
"Mechanical Engineering"
] | ||
REVIEWS | [
"Religious Studies"
] | ||
Performance evaluation of sustainable geopolymer concrete produced from ferrochrome slag and silica fume | [
"Civil and Structural Engineering",
"Environmental Engineering"
] | ||
Ultrastructural Examination and Cell Count Determinations of Avian Glomeruli from Grossly Normal and Grossly Swollen Kidneys of Broilers at Slaughter | [
"Animal Science and Zoology",
"Food Animals"
] | ||
Fabrication of solar cells with CO2 gas sensing capabilities based on a NiO/ZnO p-n junction for developing self-powered gas sensors | Abstract Solar cells based on a NiO/ZnO p-n junction structure responding to CO2 gas were fabricated by conventional RF sputtering. The developed NiO/ZnO solar cells exhibited evident photovoltaic effects and response to CO2 gas when exposed to sunlight at room temperature without thermal heating or external power supply. The open-circuit voltage, generated by the solar cells absorbing only UV light, increased in a CO2 atmosphere and decreased in air. Moreover, the response mechanism of the NiO/ZnO solar cells to CO2 gas was investigated using electrochemical impedance spectroscopy. The results suggested that the depletion layer width of the NiO/ZnO interface changed under CO2 gas with light illumination. These results represent the potential application of the NiO/ZnO p-n junction structure toward self-powered gas sensors. | Japanese Journal of Applied Physics | [
"Physics and Astronomy (miscellaneous)"
] |
Educação Ambiental: Um Balanço | Comunicações | [
"Marketing",
"Organizational Behavior and Human Resource Management",
"Strategy and Management",
"Drug Discovery",
"Pharmaceutical Science",
"Pharmacology"
] | |
The methylisothiazolinone epidemic: Is the fire out or is Rome still burning? | [
"Dermatology",
"Immunology and Allergy"
] | ||
Book Notes | The Journal of American History | [
"History and Philosophy of Science",
"History"
] | |
Abstract PS16-30: Pms1 gene: A new risk-mutation description? | Abstract INTRODUCTION: PMS1 is part of the cluster of genes related to Mismatch repair genes (MMR) and has been used for investigation in oncogenetic panels. The MMR genes play an important role in tumor control and progression, however, the role of PMS1 in this process still poorly understood and information about its role in increasing the risk of developing a hereditary cancer predisposition syndrome (SHPC) is not completely understood.AIM: To characterize clinically and genetically cancer patients with NCCN criteria for SHPC and carriers of variants in the PMS1 gene.METHODOLOGY: A total of 368 patients suspected of having SHPC, according to the National Comprehensive Cancer Network (NCCN) criteria, were investigated using a Next-Generation Sequencing (NGS) in a panel containing 31 genes. Those that showed variation in the PMS1 gene were grouped, and the tumors were characterized in clinical and molecular aspects.RESULTS: From the 368 patients analyzed, 6.8% (25/368) patients presented Variants of Uncertain Significance (VUS) in PMS1. There was a case of Breast Cancer (BC) with a variant in PMS1, not described in ClinVar, presented in heterozygosis, probably pathogenic [Chr2:190.738,325 NM_000534: c.2578delA: p.(Arg860.Glufs*14)]. Besides, this case was associated with a family history (FH) of cancer breast cancer and melanoma. It is worth mentioning that only one patient was a man, with colorectal cancer (CRC), and his FH also was CRC in addition to stomach cancer. The only change founded was the presence of VUS NM_000534:c.1615A>G:p.(Met539Val) which was identified in 32% (8/25). This VUS was the only genetic alteration observed in 20% (5/25) patients with tumors in the breast (3), thyroid (1), CRC (1), and ovary (1). One of these patients had bilateral breast cancer and thyroid tumor. The patients had their age at diagnosis ranged from 25 to 65 years, with an average of 41 years. The carriers of variants exclusively in PMS1 [40% (10/25)] had different tumors: breast (6); CRC (3); ovary (2); lymphoma (1); thyroid (1); others 32% (n = 8/25) that presented additional VUS in different genes: [ATM (2); BARD (1); CDH1 (1); CHECK2 (1); NBN (1); APC (1); POLE (1)]. Different pathogenic variants (PV) [28% (n = 7/25)] also were identified, besides the previous PMS1 VUS described. The PV was founded in ATM (1); BRCA1 (3); NF1 (1); TP53 (1); MUTYH-heterozygosis (1), and PMS1 (1) gene. A double pathogenic variation was identified in a patient (MUTYH in heterozygosis and BRCA1). The findings in PMS1, even currently classified as VUS, should highlight observation for the clinical and familiar history. Genetic panels should be increasingly used in the investigation of SPHC.CONCLUSION: The roles of PMS1 in cancer progression need further investigations. A few numbers of reports have been identified on germline PMS1 mutations, considering defined disease phenotypes. Therefore, the performance of genetic panels, including the PMS1 gene, in SHPC further investigations will expand our knowledge and permit precise genetic counseling. Citation Format: Isabelle JoyceLima Silva-Fernandes, Clarissa Gondim Picanço-Albuquerque, Maria Claudia dos Santos Luciano, Deysi Viviana Tenazoa Wong, Maria Júlia Barbosa Bezerra, Flavio Silveira Bitencourt, Francisca Fernanda Barbosa Oliveira, Paulo Goberlanio de Barros Silva, Rosane Oliveira Sant´anna, Marcos Venicio Alves Lima. Pms1 gene: A new risk-mutation description? [abstract]. In: Proceedings of the 2020 San Antonio Breast Cancer Virtual Symposium; 2020 Dec 8-11; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2021;81(4 Suppl):Abstract nr PS16-30. | [
"Cancer Research",
"Oncology"
] | |
Masthead | [
"Organic Chemistry"
] | ||
Machine learning insights concerning inflammatory and liver-related risk comorbidities in non-communicable and viral diseases | [
"Gastroenterology"
] | ||
Building on success? Future challenges for doctoral education globally | Purpose In the past 20 years, doctoral programmes have become the focus of policy initiatives. This has led to considerable changes in their structures and consequently student experience. In this essay, the author explores some of the changes by situating an examination of doctoral education-past, present, future-within the broader context of academic life, and the nature and role of research in developed economies. This analysis provides the context in which to draw out some implications for the future study of doctoral education. Design/methodology/approach The essay draws on a synthesis of the research on doctoral education, early career researcher trajectories, research structures and academic work environment. Findings The analysis suggests the following: doctoral education reform is being driven largely by policy concerns, rather than by evidence or disciplinary intention; and academic work environment is becoming less and less attractive due to increasing demands for productivity and accountability. Originality/value The author concludes with a call to action: unless we, as academics, take action on several fronts, we may find that the PhD becomes purely a policy instrument, and that in the long-term, life of an academic will no longer be attractive to PhD graduates. | [
"Education"
] | |
Marine spatial planning and the Greek experience | [
"Law",
"Management, Monitoring, Policy and Law",
"Economics and Econometrics",
"Aquatic Science"
] | ||
A cation carrier in the yeast cell wall | [
"Computer Science Applications",
"History",
"Education"
] | ||
Microlensing by halo MACHOs with a spatially varying mass function | [
"Space and Planetary Science",
"Astronomy and Astrophysics"
] | ||
Announcements | [
"Neurology (clinical)",
"Surgery"
] | ||
Aluminum-induced decreases in choline acetyltransferase, tyrosine hydroxylase, and glutamate decarboxylase in selected regions of rabbit brain | [
"Neurology (clinical)",
"Molecular Biology"
] | ||
Biomarkers of Antiangiogenic Therapy: How Do We Move From Candidate Biomarkers to Valid Biomarkers? | Journal of Clinical Oncology | [
"Cancer Research",
"Oncology"
] | |
Corrigendum: Analysis of regularized inversion of data corrupted by white Gaussian noise (2014 Inverse Problems 30 045009) | [
"Applied Mathematics",
"Computer Science Applications",
"Mathematical Physics",
"Signal Processing",
"Theoretical Computer Science"
] | ||
On the supersymmetry invariance of flat supergravity with boundary | Abstract The supersymmetry invariance of flat supergravity (i.e., supergravity in the absence of any internal scale in the Lagrangian) in four dimensions on a manifold with non-trivial boundary is explored. Using a geometric approach we find that the supersymmetry invariance of the Lagrangian requires to add appropriate boundary terms. This is achieved by considering additional gauge fields to the boundary without modifying the bulk Lagrangian. We also construct an enlarged supergravity model from which, in the vanishing cosmological constant limit, flat supergravity with a non-trivial boundary emerges properly. | Journal of High Energy Physics | [
"Nuclear and High Energy Physics"
] |
0805 Halo-Traction induced Obstructive sleep apnea | Abstract Introduction Obstructive sleep apnea (OSA) is the most common sleep-related breathing disorder. It is a multi-factorial disease with a variety of identified causes including age, male gender, obesity, craniofacial and upper airway abnormalities. We would like to describe a patient who had severe OSA following application of Halo traction, which significantly improved following the removal of the device. Report of Cases: 14-year-old male with medical history of spina bifida, chiari malformation s/p decompression, shunted hydrocephalus and severe scoliosis, was admitted to the hospital for anterior spinal discectomy L2-S1 and Halo application with traction for scoliosis. He previously had nocturnal polysomnogram (NPSG) in 2017 that demonstrated very mild mixed apnea with an apnea hypopnea index (AHI) of 5.5. Because central apneas were very brief and clustered in REM, family elected to repeat a study rather than treat. In 2019, he had a follow up study with complaints of snoring and thirst, and this demonstrated an AHI of 21 with 29 brief central apneas and 72 hypopneas, 1 obstructive apnea. He had a T&A and turbinate ablation and due to the global pandemic did not undergo repeat sleep study. During admission for his anterior spinal discectomy and Halo, he demonstrated persistent night time hypoxia. A split night sleep study showed evidence of severe OSA with pretreatment AHI of 94.4, oxygen nadir 86%. Continuous positive airway pressure (CPAP) was initiated at 5 cm of water and titrated to 11 cm of water. On CPAP of +11 severe obstructive events continued with an AHI of 40.6, oxygen nadir 92%. A bilevel positive airway pressure (BIPAP) titration study the subsequent night started at pressures of 12/6 and titrated to 21/9 with respiratory rate of 12 yet demonstrated AHI of 51, oxygen nadir 89%. Study transitioned to average volume assisted pressure support (AVAPS) with IPAP max of 26, IPAP minimum of 12 EPAP of 9, tidal volume of 175ml, rate of 12 with inadequate control of his obstructive events with an AHI of 24.8, minimum oxygen saturations of 91. While hospitalized, he remained on AVAPS with normal capillary blood gases. Halo traction was removed 2 weeks following his surgery with plan was to send him home on AVAPS and repeat NPSG in 6 weeks. However, as a result of COVID pandemic/Philips recall, CPAP was the only device available for home use, so CPAP therapy at +8 cm was trialed overnight, demonstrating oxygen nadir of 92% and a normal capillary blood gas in the morning. Patient was then discharged home on CPAP of +8 cm of water. He returned back to sleep center for a BIPAP titration study to re-establish BIPAP/AVAPS settings, as his inpatient sleep study had shown severe OSA. During the sleep study, he was started on BIPAP 12/6 and he remained on it throughout the night with 0 central and 0 obstructive events. As he did well, he was advised to continue CPAP +8 with plans to repeat the sleep study off CPAP. In clinic follow up, he reported mild skin breakdown and occasionally waking unrefreshed. Conclusion As our patient did significantly better following the removal of Halo traction device, it is likely that Halo traction device caused fixed over flexion of the cervical spine that resulted in decrease in his airway diameter, which further worsened during his sleep, and caused severe OSA. Support (If Any) | [
"Physiology (medical)",
"Neurology (clinical)"
] | |
Metal-metal vs tellurium-tellurium bonding in WTe2 and its ternary variants TaIrTe4 and NbIrTe4 | [
"Colloid and Surface Chemistry",
"Biochemistry",
"Catalysis"
] | ||
Discriminative Deep Face Shape Model for Facial Point Detection | [
"Artificial Intelligence",
"Computer Vision and Pattern Recognition",
"Software"
] | ||
Comparison of questionnaire-derived and tumour registry-derived smoking histories | [
"Cancer Research",
"Oncology"
] | ||
Response of the Nitric Oxide System to Hypobaric Hypoxia in the Aged Striatum | Background: Nitric oxide (NO) appears to play a key role in the hypoxic injury to the brain. We have previously reported that hypoxia/reoxygenation downregulated NO synthases (NOS) in the adult striatum. Until now, no data were available concerning the influence of aging in conjunction with hypoxia/reoxygenation on the NO system in the striatum. Objective: The aim of this study was to assess the role of the NO pathway in the hypoxic aged striatum. Methods: Wistar rats 24-25 months old were submitted to hypobaric hypoxia (20 min)/reoxygenation (0 h, 24 h, 5 days). Expression (PCR, immunohistochemistry/image analysis) and activity (NADPH-diaphorase/image analysis) of NOS isoforms (neuronal NOS or nNOS, endothelial NOS or eNOS, inducible NOS or iNOS) were analyzed together with nitrated protein expression (immunohistochemistry/image analysis). NO levels were indirectly quantified as nitrates/nitrites (NOx). Results: The mRNA levels of NOS isoforms were undetectable at 0 h after hypoxia in the striatum compared to the control. At later reoxygenation times, nNOS mRNA decreased, while eNOS mRNA augmented. Protein levels of nNOS and eNOS rose at 24 h after hypoxia, and iNOS protein increased at 5 days. NOx levels remained unchanged, whereas in situ NOS activity and protein nitration diminished during reoxygenation in the aged striatum. Conclusion: The aged striatum may overexpress NOS isoforms as a neuroprotective-adaptive mechanism to hypoxia. However, this mechanism may not work properly in the aged striatum, since no changes in NO levels were detected after hypoxia. This may be related to the low activity of NOS isoforms in the hypoxic striatum. | [
"Geriatrics and Gerontology",
"Aging"
] | |
Établissement des volumes cibles anatomocliniques (Clinical Target Volume) pour les cancers laryngés en fonction de la localisation de départ et des modalités d'extension | [
"Radiology, Nuclear Medicine and Imaging",
"Oncology"
] | ||
Same Coin, Different Sides: Differential Impact of Social Learning on Two Facets of Music Piracy | [
"Information Systems and Management",
"Management Science and Operations Research",
"Computer Science Applications",
"Management Information Systems"
] | ||
Effect of Reactive Self-Assembled Monolayer at the Anode Interface of Organic Light-Emitting Diode | Organic light-emitting diodes (OLEDs) were prepared on indium-tin oxide (ITO) substrates that were modified with various self-assembled monolayers (SAMs) including those which have reactive terminal units. The OLED performance was analyzed in terms of molecular length, dipole moment and HOMO level of SAM molecules estimated by the density functional theory calculation. It was suggested that the current efficiency of OLED is partly improved by controlling the carrier balance, interfacial dipole moment, and electron energy level by SAM modification. More importantly, remarkable improvement in OLED efficiency was achieved by chemically tethering the inorganic/organic interface via benzophenone-terminated SAM. The reactive SAM having benzophenone terminal group can be a promising tool to control the inorganic/organic interface for organic devices. | Journal of Nanoscience and Nanotechnology | [
"Condensed Matter Physics",
"Biomedical Engineering",
"Bioengineering"
] |
Characterization of oxygen species adsorbed on copper and nickel oxides by X-ray photoelectron spectroscopy | Surface Science | [
"Materials Chemistry",
"Surfaces, Coatings and Films",
"Surfaces and Interfaces",
"Condensed Matter Physics"
] | |
Asymptotic formulation of a differentially rotating star with small dissipation | [
"Space and Planetary Science",
"Astronomy and Astrophysics"
] | ||
Crustacean vitellogenin: a systematic and experimental analysis of their genes, genomes, mRNAs and proteins; and perspective to Next Generation Sequencing | Abstract Crustacean vitellogenesis is a process that involves Vitellin, produced via endoproteolysis of its precursor, which is designated as Vitellogenin (Vtg). The Vtg gene, mRNA and protein regulation involve several environmental factors and physiological processes, including gonadal maturation and moult stages, among others. Once the Vtg gene, mRNAs and protein are obtained, it is possible to establish the relationship between the elements that participate in their regulation, which could either be species-specific, or tissue-specific. This work is a systematic analysis that compares the similarities and differences of Vtg genes, mRNA and Vtg between the crustacean species reported in databases with respect to that obtained from the transcriptome of Callinectes arcuatus, C. toxotes, Penaeus stylirostris and P. vannamei obtained with MiSeq sequencing technology from Illumina. Those analyses confirm that the Vtg obtained from selected species will serve to understand the process of vitellogenesis in crustaceans that is important for fisheries and aquaculture. | Crustaceana | [
"Animal Science and Zoology",
"Aquatic Science"
] |
Stefano Varese, Résistance et utopie dans l’Amazonie péruvienne. Le sel de la montagne, Paris, L’Harmattan, 2015, 274 p., ISBN 978-2-343-06452-9 | [
"History"
] | ||
Chronic dietary lithium inhibits basal C-fos mRNA expression in rat brain | Progress in Neuro-Psychopharmacology and Biological Psychiatry | [
"Biological Psychiatry",
"Pharmacology"
] |
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