Title stringlengths 0 905 | Abstract stringlengths 0 11.3k | Container_Title stringlengths 0 126 | Subject listlengths 1 13 |
|---|---|---|---|
The Comparative Ecology of Impatiens capensis Meerb. (Balsaminaceae) in Central New Jersey | Bulletin of the Torrey Botanical Club | [
"Plant Science"
] | |
Digital Innovations in Financial Services: Challenges & Opportunities | There are many large forces sweeping society, from demographic and social changes to shifts in global economic power. But one force especially – namely, technological breakthroughs – has an inconsistent affect on financial services. Here in this paper important technology-driven influencers which will shape competition in financial services industry are going to be discussed. The financial services industry has seen drastic technology-led changes over the past few years. Many executives look to their IT departments to enhance efficiency and facilitate game-changing innovation – while somehow also lowering costs and continuing to support legacy systems. Meanwhile, companies are encroaching upon established markets, leading with customer friendly solutions developed from the bottom up and unencumbered by legacy systems. Customers have had their expectations set by other industries; they're now demanding better services, seamless experiences regardless of channel, and more value for his or her money. Regulators demand more from the industry too, and have began to adopt new technologies which will revolutionize their ability to gather and analyze information. The pace of change shows no signs of slowing, in reality technology-driven change is so persistent that no financial organization is immune. | YMER Digital | [
"Management, Monitoring, Policy and Law",
"Geography, Planning and Development"
] |
Political business cycles in a dynamic bipartisan voting model | [
"Statistics, Probability and Uncertainty",
"Sociology and Political Science"
] | ||
Microwave‐Assisted 1,3‐Dipolar Cycloaddition of Azomethine Ylides to [60]Fullerene: Thermodynamic Control of Bis‐Addition with Ionic Liquids Additives | [
"Organic Chemistry",
"Physical and Theoretical Chemistry"
] | ||
Management and Ideology: The Legacy of the International Scientific Management Movement. By Judith A. Merkle. (Berkeley: University of California Press, 1980. Pp. ix + 325. $18.50.) | [
"Political Science and International Relations",
"Sociology and Political Science"
] | ||
Computation of electromagnetic transients on transmission lines with nonlinear components | [
"Electrical and Electronic Engineering"
] | ||
Pulmonary function abnormalities in adult patients with acute exacerbation of bronchiectasis | Lung function impairments, especially airflow obstruction, are important features during acute exacerbation in patients with bronchiectasis. Recognition of the risk factors associated with airflow obstruction is important in the management of these exacerbations. The medical records of adult patients admitted to the Peking University People’s Hospital, Beijing, China, from 2004 to 2011 with a diagnosis of bronchiectasis were reviewed retrospectively. Univariate and multivariate analyses were used to evaluate the risk factors associated with airflow obstruction. Airflow obstruction was found in 55.6% of 156 patients hospitalized with acute exacerbation of bronchiectasis, and the risk factors associated with airflow obstruction included young age (≤14 years old) at diagnosis (odds ratio (OR) = 3.454, 95% confidence interval (CI) 1.709–6.982, p = 0.001) as well as the presence of chronic obstructive pulmonary disease (COPD; OR = 14.677, 95% CI 5.696–37.819, p = 0.001), asthma (OR = 3.063, 95% CI 1.403–6.690, p = 0.005), and wheezing on auscultation (OR = 3.279, 95% CI 1.495–7.194, p = 0.003). The C-reactive protein (13.9 mg/dl vs. 6.89 mg/dl, p = 0.005), partial pressure of arterial oxygen (66.7 ± 8.57 mmHg vs. 89.56 ± 12.80 mmHg, p | Chronic Respiratory Disease | [
"Pulmonary and Respiratory Medicine"
] |
High-Spatial-Resolution High-Temperature Sensor Based on Ultra-Short Fiber Bragg Gratings With Dual-Wavelength Differential Detection | [
"Atomic and Molecular Physics, and Optics"
] | ||
Sensitive Detection of Clonal Immunoglobulin Rearrangements in Frozen and Paraffin Embedded Tissues by Polymerase Chain Reaction Heteroduplex Analysis | [
"Cell Biology",
"Molecular Biology",
"Pathology and Forensic Medicine"
] | ||
What do we Learn from a Machine Understanding News Content? Stock Market Reaction to News | [
"Industrial and Manufacturing Engineering",
"Polymers and Plastics",
"History",
"Business and International Management"
] | ||
Midwestern Section ASAS 1983 Younger Animal Scientist Extension Award | [
"Genetics",
"Animal Science and Zoology",
"Food Science"
] | ||
α2-Adrenergic Receptor-Mediated Ca2+ Influx and Release in Porcine Myometrial Cells1 | [
"Cell Biology",
"Reproductive Medicine"
] | ||
Thermodynamic and physiochemical insights into chickpea protein-Persian gum interactions and environmental effects | [
"Molecular Biology",
"Biochemistry",
"Structural Biology"
] | ||
Purification and characterization of chicken brain cytosolic aspartate aminotransferase | Neurochemical Research | [
"Cellular and Molecular Neuroscience",
"Biochemistry"
] | |
33–43 GHz and 66–86 GHz VCO With High Output Power in an 80 GHz ${\rm f | [
"Electrical and Electronic Engineering",
"Condensed Matter Physics"
] | ||
Knowledge, attitudes, and behaviors toward skin cancer among marine fisheries students of Udayana University, Bali | [
"Oncology",
"Hematology"
] | ||
Arachidonate and other fatty acids mobilize Ca2+ ions and stimulate β-glucuronidase release in a Ca2+-dependent fashion from undifferentiated HL-60 cells | [
"Cell Biology",
"Molecular Biology",
"Physiology"
] | ||
Farbspeicherungen an der menschlichen Leukocytenkultur | [
"Cell Biology",
"Plant Science"
] | ||
Superconvergence of finite element method for parabolic problem | We study superconvergence of a semi-discrete finite element scheme for parabolic problem. Our new scheme is based on introducing different approximation of initial condition. First, we give a superconvergence ofuh−Rhu, then use a postprocessing to improve the accuracy to higher order. | International Journal of Mathematics and Mathematical Sciences | [
"Mathematics (miscellaneous)"
] |
Health care utilization associated with adverse events (AEs) among metastatic non-small cell lung cancer (mNSCLC) patients treated with immunotherapy or chemotherapy. | e20655 Background: Chemotherapy and immunotherapy (IO) are associated with increased overall survival in patients with mNSCLC, yet real-world data on AE-associated healthcare utilization are sparse. This study assessed incidence and utilization associated with AEs among patients initiating first-line treatment for mNSCLC with IO, IO with chemotherapy (IC), or chemotherapy alone (CH). Methods: Data were claims from commercial and Medicare Advantage patients (Jan 2008-Feb 2018). Inclusion criteria were mNSCLC, health plan enrollment for ≥6 months pre- (baseline) and ≥1 month post-index date; initiation of recommended systemic therapy for mNSCLC. Excluded were targeted or small-cell lung cancer therapy, and baseline surgery or other systemic therapy. AE incidence and healthcare utilization were measured from start of 1st line therapy until earliest of start of 2nd line therapy or 180 days. AEs evaluated included hematologic, GI, endocrine, infections, infusion reactions, muscle, neurological, and respiratory. Results: Cohorts were 8,818 CH, 482 IO, and 412 IC. Mean age was older for IO (72 yrs, vs. 69 IC, 68 CH; P | [
"Cancer Research",
"Oncology"
] | |
A note from the Editor in Chief | [
"Computer Graphics and Computer-Aided Design",
"Human-Computer Interaction"
] | ||
A Wideband Microstrip Common-Mode Suppression Filter Using Signal Interference Techniques | [
"Electrical and Electronic Engineering",
"Condensed Matter Physics"
] | ||
The Outcomes of Conservative Nonpharmacological Treatments for Achilles Tendinopathy: An Umbrella Review | Achilles tendinopathy (AT) is the most common injury of the Achilles tendon and represents 55–65% of all Achilles tendon clinical diagnoses. AT is characterized by pain, swelling, and impaired performance. ATs can be divided into two types, according to anatomical location—midportion AT (MAT) and insertional AT (IAT). MAT more often occurs in older, less active, and overweight populations, while IAT usually occurs in the more physically active population. Both types of AT can be treated by different treatments, such as surgery, conservative pharmacological treatments, and conservative nonpharmacological treatments. This umbrella review aims to assemble the evidence from all available systematic reviews and/or meta-analyses to determine which conservative nonpharmacological treatments are most commonly used and have the greatest effects. Three major electronic scientific databases (PubMed, Scopus, and Web of Science) were screened. The reference lists of several recent articles on AT were also searched. We found 50 articles that met the inclusion criteria. The methodological quality of the included articles was assessed using the AMSTAR 2 tool. Eccentric (ECC) exercise, isotonic (ISOT) exercise, and acupuncture treatment showed the greatest effects for treating MAT as a standalone therapy. Meanwhile, extracorporeal shockwave therapy and ECC exercise provided the best outcomes for treating IAT as individual treatments. However, an even greater pain decrease, greater function improvement, and greater patient satisfaction for treating either MAT or IAT were achieved with combined protocols of ECC exercise with extracorporeal shockwave therapy (in both cases), ECC exercise with cold air and high-energy laser therapy (in the case of IAT), or ECC exercise with ASTYM therapy (in the case of IAT). | [
"Fluid Flow and Transfer Processes",
"Computer Science Applications",
"Process Chemistry and Technology",
"Instrumentation"
] | |
A short-term operating room surgery scheduling problem integrating multiple nurses roster constraints | [
"Artificial Intelligence",
"Medicine (miscellaneous)"
] | ||
Founders, foundations and early identities: football’s early growth in Barcelona | [
"Sociology and Political Science",
"Cultural Studies",
"Social Psychology"
] | ||
Digoxin bioavailability during quinidine administration | [
"Pharmacology (medical)",
"Pharmacology"
] | ||
Life and Art in the Countryside: Happiness and/or Roman Virtue? | [
"Classics"
] | ||
Reply to comment on “Thermodynamic modelling of an system using the ionic model” by I.-H. Jung and Y.-B. Kang | Calphad | [
"Computer Science Applications"
] | |
International Journal of Nursing Terminologies and Classifications | [
"Nursing (miscellaneous)",
"Fundamentals and Skills"
] | ||
Assessment of Meteorological Drought in Korea under Climate Change | Drought has become one of the most important elements for water resources planning and management in Korea. The objective of this study is to estimate the spatial distribution of drought and change in the drought characteristics over time due to climate change. For the spatial characterization of drought, the standardized precipitation index (SPI) is calculated from the 45 observatories in Korea and the spatial distribution is also estimated based on the joint probability analysis using the copula method. To analyze the effect of climate change, spatial distribution of drought in the future is analyzed using the SPI time series calculated from Representative Concentration Pathways (RCPs) scenarios and HADGEM3-RA regional climate model. The results show that the Youngsan River and the northwest of Nakdong River basins in Korea have nearly doubled drought amount compared to the present and are most vulnerable to drought in near future (2016 to 2039 years). | [
"Atmospheric Science",
"Pollution",
"Geophysics"
] | |
High-throughput genotyping of wheat-barley amphiploids utilising diversity array technology (DArT) | Abstract Background Hordeum chilense, a native South American diploid wild barley, is one of the species of the genus Hordeum with a high potential for cereal breeding purposes, given its high crossability with other members of the Triticeae tribe. Hexaploid tritordeum (×Tritordeum Ascherson et Graebner, 2n=6×=42, AABBHchHch) is the fertile amphiploid obtained after chromosome doubling of hybrids between Hordeum chilense and durum wheat. Approaches used in the improvement of this crop have included crosses with hexaploid wheat to promote D/Hch chromosome substitutions. While this approach has been successful as was the case with triticale, it has also complicated the genetic composition of the breeding materials. Until now tritordeum lines were analyzed based on molecular cytogenetic techniques and screening with a small set of DNA markers. However, the recent development of DArT markers in H. chilense offers new possibilities to screen large number of accessions more efficiently. Results Here, we have applied DArT markers to genotype composition in forty-six accessions of hexaploid tritordeum originating from different stages of tritordeum breeding program and to H. chilense-wheat chromosome addition lines to allow their physical mapping. Diversity analyses were conducted including dendrogram construction, principal component analysis and structure inference. Euploid and substituted tritordeums were clearly discriminated independently of the method used. However, dendrogram and Structure analyses allowed the clearest discrimination among substituted tritordeums. The physically mapped markers allowed identifying these groups as substituted tritordeums carrying the following disomic substitutions (DS): DS1D (1Hch), DS2D (2Hch), DS5D (5Hch), DS6D (6Hch) and the double substitution DS2D (2Hch), DS5D (5Hch). These results were validated using chromosome specific EST and SSR markers and GISH analysis. Conclusion In conclusion, DArT markers have proved to be very useful to detect chromosome substitutions in the tritordeum breeding program and thus they are expected to be equally useful to detect translocations both in the tritordeum breeding program and in the transference of H. chilense genetic material in wheat breeding programs. | [
"Plant Science"
] | |
A practical method of assessing the freezing tolerance of large populations of field-grown winter cereals | A practical method for determining the freezing tolerance of winter cereals using "rootrainers"™ is outlined and compared to the method described by Gusta et al. (1978). Advantages to this method are: a reduction in labour, the plants are stored intact, the crown and root system are disturbed minimally, no transplanting following freezing is required, root regrowth can readily be evaluated and large numbers of plants can be catalogued and stored at sub-zero temperatures for future evaluation. Whole plants frozen using the rootrainer method had a freezing tolerance similar to trimmed plants frozen in moist sand as described in the original method by Gusta et al. (1978). Key words: Winter wheat, winter cereals, freezing tolerance | [
"Horticulture",
"Plant Science",
"Agronomy and Crop Science"
] | |
Digestive proteinases of the larger black flour beetle, Cynaeus angustus (Coleoptera: Tenebrionidae) | AbstractDigestion in the larger black flour beetle, Cynaeus angustus (LeConte), was studied to identify new control methods for this pest of stored grains and grain products. The physiological pH of the larval gut, as measured with extracts in water, was approximately 6.1, and the pH for optimal hydrolysis of casein by gut extracts was 6.2 when buffers were reducing. However, under non-reducing conditions, hydrolysis of casein and synthetic serine proteinase substrates was optimal in alkaline buffer. Three major proteinase activities were observed in zymograms using casein or gelatin. Caseinolytic activity of C. angustus gut extracts was inhibited by inhibitors that target aspartic and serine proteinase classes, with minor inhibition by a cysteine proteinase inhibitor. In particular, soybean trypsin and trypsin/chymotrypsin inhibitors were most effective in reducing the in vitro caseinolytic activity of gut extracts. Based on these data, further studies are suggested on the effects of dietary soybean inhibitors of serine proteinases, singly and in combination with aspartic and cysteine proteinase inhibitors, on C. angustus larvae. Results from these studies can be used to develop new control strategies to prevent damage to grains and stored products by C. angustus and similar coleopteran pests. | Bulletin of Entomological Research | [
"Insect Science",
"Agronomy and Crop Science"
] |
Interpenetrating polymer networks on the basis of polyurethanes and polyurethane ionom ers | [
"Materials Chemistry",
"Polymers and Plastics"
] | ||
“Qualcosa è cambiato”: il bambino e la dialisi peritoneale, oggi | Nell'ultimo decennio, si è verificato un importante cambiamento della situazione culturale e socio-economica delle famiglie che assistono i bambini che necessitano di dialisi (aumento del numero delle famiglie monoparentali o con genitori separati e delle famiglie di immigrati e incremento della povertà e, quindi, della necessità di lavoro per entrambi i genitori). Vi è stato, inoltre, un aumento dei pazienti con comorbidità severe correlate a prematurità o a sindromi genetiche, ora avviati alla dialisi, contrariamente a quanto si faceva in passato. Si è palesato con maggiore chiarezza il rischio di peritonite sclerosante con un'importante quota di decessi, in parte, ma non completamente, correlata al numero di peritoniti e alla durata della dialisi peritoneale. Nello stesso tempo, si è assistito a un sostanziale miglioramento delle tecniche dialitiche, peraltro maggiormente evidente per le metodiche extracorporee. Per tutti questi motivi, l'assioma degli anni '90 “bambino in dialisi = bambino in dialisi peritoneale” non è più da considerarsi del tutto valido. La scelta della metodica più consona al singolo paziente e alla sua famiglia dipende, quindi, dal lavoro di valutazione di un team multidisciplinare, che consideri attentamente sia gli aspetti clinici del bambino con insufficienza renale cronica terminale sia i fattori psico-sociali ed economici relativi ai vari tipi di trattamento, nello specifico di una determinata famiglia. Solo in questo modo si possono prevenire gli insuccessi terapeutici (dropouts), spesso riportati per alcune categorie di bambini in dialisi peritoneale. La conseguenza di quanto detto, dal punto di vista epidemiologico, è stata, in questi ultimi anni, nel nostro centro, la ridistribuzione della prima scelta di trattamento a favore dell'emodialisi. | [
"Pharmacology (medical)"
] | |
JME volume 49 issue 1 Cover and Front matter | [
"Health Policy",
"Issues, Ethics and Legal Aspects"
] | ||
La médaille d'Isabella Andreini | [
"Archeology"
] | ||
Fabrication of electrospun almond gum/PVA nanofibers as a thermostable delivery system for vanillin | International Journal of Biological Macromolecules | [
"Molecular Biology",
"Biochemistry",
"Structural Biology"
] | |
UK agricultural exporters’ perceived barriers and government assistance requirements | Marketing Intelligence & Planning | [
"Marketing"
] | |
The depth of the Rees algebra of three general binary forms | Communications in Algebra | [
"Algebra and Number Theory"
] | |
Measuring Uncertainty and Its Impact on the Economy | The Review of Economics and Statistics | [
"Economics and Econometrics",
"Social Sciences (miscellaneous)"
] | |
The importance of acid site locations for n-butene skeletal isomerization on ferrierite | [
"Physical and Theoretical Chemistry",
"Process Chemistry and Technology",
"Catalysis"
] | ||
A Review Of: “Congress, the Press, and Political Accountability” | [
"Sociology and Political Science",
"Communication"
] | ||
P59 Hypokalemic paralysis as initial presentation in female patients with primary Sjogren's syndrome—a case series | [
"Rheumatology"
] | ||
Deciphering America: The American Scene | [
"Literature and Literary Theory"
] | ||
Treatment of experimental venous thrombosis with streptokinase and ancrod (Arvin) | Abstract Phenol was applied to the exposed femoral veins of anaesthetized dogs and the fate of the induced thrombi was followed by serial phlebography and eventual histology. Thrombi less than 24 hours old were treated with a 9-hour infusion of streptokinase and patency was restored in 38 of 48 veins (79 percent). Rethrombosis had occurred 6 days later in all of 10 veins which received no further treatment. Five of 14 veins (36 per cent) remained patent when dogs were given treatment with ancrod following thrombolysis by streptokinase. Probable explanations for rethrombosis in the other 9 veins despite ancrod therapy were failure to clear the veins completely of thrombi with streptokinase and failure to maintain a sufficiently low level of plasma fibrinogen in some dogs because of bleeding. Streptokinase therapy followed by ancrod warrants further study in the treatment of deep-vein thrombosis. | British Journal of Surgery | [
"Surgery"
] |
Gelatin Films from Carp Skin Crosslinked by Gallic Acid and Incorporated with Chitosan/Tuna Lipid Fractions | Journal of Polymers and the Environment | [
"Materials Chemistry",
"Polymers and Plastics",
"Environmental Engineering"
] | |
Tanshinone IIA Protects Against Cardiac Hypertrophy via Inhibiting Calcineurin/Nfatc3 Pathway | [
"Cell Biology",
"Developmental Biology",
"Molecular Biology",
"Applied Microbiology and Biotechnology",
"Ecology, Evolution, Behavior and Systematics"
] | ||
Estimating E-workability Components Across Central European Countries | At present, shifting the workforce to a home-based work environment was and is a necessary response to Covid-19 crisis. In the post-pandemic work environment, e-working may continue being popular even in agribusiness. The study objective was to examine the motives for adopting face-to-display working environments within selected V4 countries and Austria in 2019, with the study being done in terms of the various components related to the spread of e-working. The study adopted Spearman’s Rho correlation using 16 numerical variables to measure the strength of association between two variables (e-working and 16 numerical variables). This study investigated the impact of 16 selected factors in determining e-workability in V4 countries and Austria. The study found that when e-working and the percentage of GDP services are considered, a very strong positive correlation is indicated: As the GDP increases, the probability of e-working increases. High levels of education and of technology reveal a strong positive correlation. When the number of highly educated employees decreases, the number of e-workers decreases. In respect of technology, greater utilisation of digital public services, internet access and computer access from the home increase the likelihood of e-working. A medium education level and the use of the internet show a strong negative correlation: When the medium educational attainment level rises, e-working decreases. As the utilisation of the internet increases, the proportion of e-working falls. These components affected higher e-workability. Through the examination of the motives for adopting face-to-display working environments, this study advances the knowledge in the e-working field of the selected countries. | Agris on-line Papers in Economics and Informatics | [
"Management, Monitoring, Policy and Law",
"Economics, Econometrics and Finance (miscellaneous)",
"Agricultural and Biological Sciences (miscellaneous)",
"Geography, Planning and Development"
] |
A sphingosine kinase inhibitor combined with temozolomide induces glioblastoma cell death through accumulation of dihydrosphingosine and dihydroceramide, endoplasmic reticulum stress and autophagy | AbstractGlioblastomas (GBMs) are very aggressive tumors with low chemosensitivity. The DNA-alkylating agent temozolomide (TMZ) is currently the most efficient chemotoxic drug for GBM therapy; however, many patients develop resistance to TMZ. Combining TMZ with another agent could present an improved treatment option if it could overcome TMZ resistance and avoid side effects. Sphingosine kinase inhibitors (SKIs) have emerged as anticancer agents. Sphingosine kinases are often overexpressed in tumors where their activity of phosphorylating sphingosine (Sph) contributes to tumor growth and migration. They control the levels of the pro-apoptotic ceramide (Cer) and Sph and of the pro-survival sphingosine-1 phosphate. In the present work, TMZ was combined with a specific SKI, and the cytotoxic effect of each drug alone or in combination was tested on GBM cell lines. The combination of sublethal doses of both agents resulted in the cell death potentiation of GBM cell lines without affecting astrocyte viability. It triggered a caspase-3-dependent cell death that was preceded by accumulation of dihydrosphingosine (dhSph) and dihydroceramide (dhCer), oxidative stress, endoplasmic reticulum stress, and autophagy. Autophagy was identified as the crucial switch that facilitated induction of this cell death potentiation. The sublethal dose of the inhibitor induced these stress events, whereas that of TMZ induced the destructive autophagy switch. Remarkably, neither Cer nor Sph, but rather the Cer intermediates, dhSph and dhCer, was involved in the cytotoxicity from the combination. Cell lines sensitive to the combination expressed low levels of the antioxidant enzyme glutathione peroxidase-1, indicating this enzyme as a potential marker of sensitivity to such treatment. This work shows for the first time a strong interaction between a SKI and TMZ, leading to a tumor cell-specific death induction. It further demonstrates the biological relevance of dihydrosphingolipids in cell death mechanisms and emphasizes the potential of drugs that affect sphingolipid metabolism for cancer therapy. | [
"Cancer Research",
"Cell Biology",
"Cellular and Molecular Neuroscience",
"Immunology"
] | |
Exciton characteristics of Tl1−x CuxInS2 single crystals | [
"Condensed Matter Physics",
"Electronic, Optical and Magnetic Materials"
] | ||
The neuronal nicotinic acetylcholine receptors α4* and α6* differentially modulate dopamine release in mouse striatal slices | [
"Cellular and Molecular Neuroscience",
"Biochemistry"
] | ||
Studies on 4-methylumbelliferone caprylate as a substrate for hog pancreatic lipase | [
"Cell Biology",
"Molecular Biology",
"Biochemistry",
"Biophysics"
] | ||
Ultrasonic cell disruption of stabilised sludge with subsequent anaerobic digestion | Ultrasonics | [
"Acoustics and Ultrasonics"
] | |
Induced Anti-Non Gal Antibodies in Human Xenograft Recipients | [
"Transplantation"
] | ||
Nano-TaC powder synthesized using modified spark plasma sintering apparatus and its densification | [
"Materials Chemistry",
"Surfaces, Coatings and Films",
"Process Chemistry and Technology",
"Ceramics and Composites",
"Electronic, Optical and Magnetic Materials"
] | ||
Correlation between Antibiotic Consumption and Hand Hygiene Compliance Among Anesthesia and Intensive Care Healthcare Professionals | Aims: The aim of this study was to investigate the correct use of gloves and alcohol-based products for hand hygiene and identify opportunities for hand hygiene replacement with gloves among healthcare professionals working in the Department of Anesthesia and Intensive Care of a tertiary care University Hospital. Background: Two centuries have passed since the discovery of Semmelweis that the “puerperal fever” was due to an infection transmitted by the hands. Currently the hand hygiene is still not well performed, rather it is often replaced by the improper use of gloves. Microbial transmission is estimated to occur in one-fifth of all contact cases. Objective: To investigate the correct use of gloves and alcohol-based products for hand hygiene and identify opportunities for hand hygiene replacement with gloves among healthcare professionals. Furthermore, to correlate the consumption data of the hydroalcoholic solution and the amount of antibiotics used for the treatment of hospital-acquired infections. Method: The study was conducted over six months period (from January to June 2018); during this period, 20 monitoring sessions were performed. The following indicators were evaluated: a) Non-adherence to hand hygiene with concomitant use of gloves; b) Adhesion to alcoholic friction of hands; c) Hand-washing adhesion. Instead, the consumption data, provided by the hospital ward itself, were used for the evaluation of d) The antibiotics used in the treatment of hospital-acquired infections; e) The hydro-alcoholic solution used by the healthcare professionals for hand hygiene. Results: The frequency of non-adherence to hand hygiene was very high at the beginning of the study, subsequently it decreased to about a half percent to that at the initial stage. The adhesion to alcoholic friction of hands increased during the study period. Otherwise, the hand-washing adhesion slightly reduced, especially in March probably due to the recruitment of new inadequately trained nursing staff. The trend of antibiotic consumption was similar to handwashing. The consumption of hydro-alcoholic solution was very low, however over time, it increased considerably until the end of the study. Conclusion: In light of the findings from this work, it is necessary to make the hospital staff increasingly aware of the correct practice of hand hygiene and to organize training and informative sessions to promote the health of the individual and the community. | [
"Anesthesiology and Pain Medicine"
] | |
Elevation of c-FLIP in Castrate-Resistant Prostate Cancer Antagonizes Therapeutic Response to Androgen Receptor–Targeted Therapy | Abstract Purpose: To characterize the importance of cellular Fas-associated death domain (FADD)–like interleukin 1β-converting enzyme (FLICE) inhibitory protein (c-FLIP), a key regulator of caspase-8 (FLICE)–promoted apoptosis, in modulating the response of prostate cancer cells to androgen receptor (AR)–targeted therapy. Experimental Design: c-FLIP expression was characterized by immunohistochemical analysis of prostatectomy tissue. The functional importance of c-FLIP to survival and modulating response to bicalutamide was studied by molecular and pharmacologic interventions. Results: c-FLIP expression was increased in high-grade prostatic intraepithelial neoplasia and prostate cancer tissue relative to normal prostate epithelium (P < 0.001). Maximal c-FLIP expression was detected in castrate-resistant prostate cancer (CRPC; P < 0.001). In vitro, silencing of c-FLIP induced spontaneous apoptosis and increased 22Rv1 and LNCaP cell sensitivity to bicalutamide, determined by flow cytometry, PARP cleavage, and caspase activity assays. The histone deacetylase inhibitors (HDACi), droxinostat and SAHA, also downregulated c-FLIP expression, induced caspase-8- and caspase-3/7–mediated apoptosis, and increased apoptosis in bicalutamide-treated cells. Conversely, the elevated expression of c-FLIP detected in the CRPC cell line VCaP underpinned their insensitivity to bicalutamide and SAHA in vitro. However, knockdown of c-FLIP induced spontaneous apoptosis in VCaP cells, indicating its relevance to cell survival and therapeutic resistance. Conclusion: c-FLIP reduces the efficacy of AR-targeted therapy and maintains the viability of prostate cancer cells. A combination of HDACi with androgen deprivation therapy may be effective in early-stage disease, using c-FLIP expression as a predictive biomarker of sensitivity. Direct targeting of c-FLIP, however, may be relevant to enhance the response of existing and novel therapeutics in CRPC. Clin Cancer Res; 18(14); 3822–33. ©2012 AACR. | [
"Cancer Research",
"Oncology"
] | |
BSAVA Membership rates | [
"Small Animals"
] | ||
The effect of hydrogen peroxide / L-histidine-induced DNA single- vs. double-strand breaks on poly(ADP-ribose)polymerase | European Journal of Pharmacology: Molecular Pharmacology | [
"Pharmacology"
] | |
Zervikale Wirbelsäulenchirurgie des Rheumatikers | [
"Rheumatology"
] | ||
The anti‐secession law, framing, and political change in Taiwan | [
"Political Science and International Relations",
"Sociology and Political Science"
] | ||
Abstract PD6-07: Volumetric changes on longitudinal dynamic contrast enhanced MR imaging (DCE-MRI) as an early treatment response predictor to neoadjuvant systemic therapy (NAST) in triple negative breast cancer (TNBC) patients | Abstract Background and Purpose:There is currently a lack of recognized imaging criteria for prediction of treatment response to NAST in breast cancer patients with recent reports showing that breast MRI is the most accurate modality for evaluation of NAST response. DCE-MRI evaluates tumor perfusion that influences tumor enhancement at the post-contrast subtraction images and allows for more accurate measurement of changes in tumor volume during NAST. In this study, we evaluated the ability of tumor volumetric changes after 2 and 4 cycles of NAST by longitudinal ultrafast DCE-MRI to predict pathologic complete response (pCR) in TNBC undergoing NAST. Materials and Methods: Stage I-III TNBC patients enrolled in an IRB approved prospective clinical trial (ARTEMIS, NCT02276433) who had ultrafast DCE-MRI at baseline (BL, N=103), post 2 cycles (C2, N=59), and post 4 cycles (C4, N=103) of anthracycline-based NAST,and had surgery, were included in this analysis. Tumor volume was calculated using 3D measurements of the index lesion at BL, C2, and C4. Percent change of tumor volume (%TV) between BL, C2, and C4 was calculated at early (9-12 sec) and delayed (360-480 sec) phases of DCE-MRI. The largest lesion was used for analysis in patients with multicentric or multifocal disease. Demographic, clinical, and pathologic data and treatment response at surgery (pCR versus non-pCR) were documented. Receiver operating characteristics curve (ROC) analysis was performed for prediction of pCR status. Positive predictive value (PPV), negative predictive value (NPV) and Youden Index were used to select %TV cut-off thresholds for pCR prediction.Results: 103 patients (median age, 53 years; range, 24-79 years) were included, 48 (47%) had pCR, and 55 (53%) had non-pCR at surgical pathology. The %TV reduction at C2 DCE-MRI was predictive of pCR on both early phase DCE MRI (AUC, 0.873; CI:0.779-0.968, p < .0001) and delayed phase DCE MRI (AUC, 0.844; CI:0.742-0.947, p < .0001). Optimal thresholds were as follows: 70% TV reduction on early phase DCE MRI with Youden’s index of 1.58 was able to predict pCR correctly for 79% of patients with PPV of 81%; 75% TV reduction on delayed phase with Youden’s Index of 1.44 was able to predict pCR correctly for 71% of patients with PPV of 85%.%TV reduction was also predictive of pCR at the C4 time point on both early phase DCE MRI (AUC, 0.761; CI:0.665-0.856, p < .0001) and delayed phase DCE MRI (AUC, 0.737; CI:0.641-0.833, p < .0001). Optimal thresholds were as follows: 90% TV reduction on early phase DCE MRI with Youden’s index of 1.43 was able to correctly predict pCR in 72% of patients with PPV of 70%; and 90% TV reduction on delayed phase with Youden’s Index of 1.34 was able to predict pCR correctly in 68% of patients with PPV of 71%.Conclusion: Our data shows that percent tumor volume reduction by DCE-MRI after 2 and 4 cycles of NAST was able to predict pCR in TNBC with high accuracy and can be used as an early imaging biomarker of NAST response prediction. Volumetric changes by longitudinal DCE-MRI can be used to differentiate chemoresistant and chemosensitive TNBC patients as early as after 2 cycles of NAST, and can help to triage patients for treatment de-escalation or targeted therapy. Citation Format: Gaiane Margishvili Rauch, Adrada E Beatriz, Rosalind P Candelaria, Nabil Elshafeey, Abeer H Abdelhafez, Benjamin C Musall, Jia Sun, Medina Boge, Rania M.M Mohamed, Jong Bum Son, Shu Zhang, Jessica Leung, Deanna Lane, Marion Scoggins, David Spak, Elsa Arribas, Lumarie Santiago, Gary J Whitman, Huong T. Le-Petross, Tanya W Moseley, Jason B. White, Elizabeth Ravenberg, Ken-Pin Hwang, Peng Wei, Lei Huo, Jennifer K Litton, Vicente Valero, Debu Tripathy, Alastair M Thompson, Mark D Pagel, Jingfei Ma, Wei T Yang, Stacy Moulder. Volumetric changes on longitudinal dynamic contrast enhanced MR imaging (DCE-MRI) as an early treatment response predictor to neoadjuvant systemic therapy (NAST) in triple negative breast cancer (TNBC) patients [abstract]. In: Proceedings of the 2020 San Antonio Breast Cancer Virtual Symposium; 2020 Dec 8-11; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2021;81(4 Suppl):Abstract nr PD6-07. | [
"Cancer Research",
"Oncology"
] | |
Electron-impact ionization of highly charged hydrogenic atomic ions | [
"Atomic and Molecular Physics, and Optics"
] | ||
Designing PolyHIPE/CNC Nanocomposites for Application of Environmental Adsorption Processes | Journal of Polymers and the Environment | [
"Materials Chemistry",
"Polymers and Plastics",
"Environmental Engineering"
] | |
James Beck, ed. Raphael before Rome. (National Gallery of Art, Washington, Studies in the History of Art, 17.) Hanover-London: University Press of New England, 1986. 210 pp. $27.50. | [
"Literature and Literary Theory",
"Visual Arts and Performing Arts",
"History"
] | ||
Steroid Control of Gonadotropin Secretion and Ovarian Function in Heifers | [
"Endocrinology"
] | ||
A 12-Bit 500-MS/s Current Steering CMOS DAC for High-Speed PLC Modems | A 12-bit 500-MS/s current steering digital-to-analog converter (DAC) for high-speed power line communication (PLC) modems is presented in this paper. The performance of current steering DAC is limited by the current cell mismatches and glitch problems caused by switching timing errors. In this paper, the current cell design procedure is presented to minimize random mismatches. Then, a new data-weighted averaging (DWA) technique with fewer glitches and low hardware complexity is proposed to compensate for the gradient mismatch. Spurious-free dynamic range (SFDR) improvement and low complexity are effectively achieved by employing both a row–column structure and a (CSA) structure as the floor plan of the proposed DAC. The proposed DAC is implemented in a standard 0.18-[Formula: see text]m CMOS process with an active area of 2.445[Formula: see text]mm2, which achieves a differential non linearity (DNL) of 0.25[Formula: see text]LSB and an integral non-linearity (INL) of 0.19[Formula: see text]LSB. Additionally, the SFDR increases by 13.2[Formula: see text]dB (on average) when employing the proposed DWA technique. The total power consumption of the proposed DAC is 176[Formula: see text]mW from a 1.8-V supply voltage. | [
"Electrical and Electronic Engineering",
"Hardware and Architecture"
] | |
Acting out hostility in normal volunteers: Negative correlation with levels of 5HIAA in cerebrospinal fluid | [
"Biological Psychiatry",
"Psychiatry and Mental Health"
] | ||
Research priorities and best practices for managing climate risk and climate change adaptation in Australian agriculture | [
"Management, Monitoring, Policy and Law",
"Geography, Planning and Development"
] | ||
THE CHEMICAL AND PHYSICAL EXAMINATION OF PORTLAND CEMENT. | Journal of the American Chemical Society | [
"Colloid and Surface Chemistry",
"Biochemistry",
"Catalysis"
] | |
Die Einwanderung der Slaven in das Oströmische Reich im Lichte der Sprachforschung | Zeitschrift für Slawistik | [
"Literature and Literary Theory",
"Linguistics and Language",
"Language and Linguistics",
"Cultural Studies"
] | |
Shared identity content between leader and follower influences intentional mobilization and challenge and threat states | [
"Applied Psychology"
] | ||
An Evaluation of Vitek2™ Direct Susceptibility Testing (DST) of Gram-Negative Bacteria (GNB) from Positive Blood Cultures (+BC). | Open Forum Infectious Diseases | [
"Infectious Diseases",
"Oncology"
] | |
Ratio | [
"Philosophy"
] | ||
Preparation of neurotensin analogs with a novel pro-tyr replacement | [
"Organic Chemistry",
"Clinical Biochemistry",
"Drug Discovery",
"Pharmaceutical Science",
"Molecular Biology",
"Molecular Medicine",
"Biochemistry"
] | ||
Development of cryopelletization and formulation measures to improve stability of Echis carinatus venum protein for use in diagnostic rotational thromboelastometry | [
"Pharmaceutical Science"
] | ||
Surface structure of GaAs(001)-(2 × 4) α, β and γ phases | [
"Materials Chemistry",
"Inorganic Chemistry",
"Condensed Matter Physics"
] | ||
The Relation of Cumulative Demographic Risk to Mothers' Responsivity and Control: Examining the Role of Toddler Temperament | [
"Developmental and Educational Psychology",
"Pediatrics, Perinatology and Child Health"
] | ||
Modelling of Spouted and Spout-Fluid Beds: Key for Their Successful Scale Up | [
"Energy (miscellaneous)",
"Energy Engineering and Power Technology",
"Renewable Energy, Sustainability and the Environment",
"Electrical and Electronic Engineering",
"Control and Optimization",
"Engineering (miscellaneous)"
] | ||
Clinical recommendations of Cochrane reviews in pediatric gastroenterology: Systematic analysis | [
"Pediatrics, Perinatology and Child Health"
] | ||
Using novel strain aging kinetics models to determine the effect of solution temperature on critical strain of Al-Zn-Mg-Cu alloy | Journal of Alloys and Compounds | [
"Materials Chemistry",
"Metals and Alloys",
"Mechanical Engineering",
"Mechanics of Materials"
] | |
Items | [
"Obstetrics and Gynecology"
] | ||
Development and Maintenance of the Ethiopian Legal Information Website | Information and Communication Technology in general and the internet in particular have been creating unprecedented opportunities in facilitating and streamlining access to information. Websites have become a common way of publishing legal information for the public in many countries. In Ethiopia, however, the availability of legal websites has been very limited or non-existent. Except for the constitution, no other basic Ethiopian law has ever been published online. To benefit from the tremendous potentials of the internet, a project was initiated to develop an Ethiopian Legal Information Web Site.Based on users' requirements obtained from questionnaire analysis, and current paradigms and implications, the Ethiopian Legal Information Website was designed, developed, implemented and maintained. The website is an online database of Ethiopian basic laws developed by Mekelle University, Ethiopia, in cooperation with the Non-Western Law Department of Ghent University, Belgium.Basic laws included on the site at present are the Ethiopian Constitution, Civil Code, Criminal Code, Civil Procedure Code, Criminal Procedure Code, Commercial Code and Family Code. The laws can be viewed and used in full text html, whereas some of the laws including the 2004 Criminal Code, Family Code, FDKE Constitution and the Tigray Regional State Constitution are available in pdf Laws can be searched by keywords using the site search engine. Comments and suggestions from experts and Ethiopian laws users have been collected, hence modifications, improvements and additions have been made to the website. The Ethiopian Legal Information Website was first hosted on the University of Ghent internet server and currently in the Mekelle University server at http://mail.mu.edu. et/~ethiopialaws/.1 The Ethiopian Legal Information Website has been found to be a useful web portal to access and use the basic Ethiopian laws. The University of Ghent, ILO, the Library of Congress, AUSTLII, WASHLAW, WIKIPEDIA and other major legal web portals make citations in reference to the site. While the website currently contains only the basic laws of the federal government, an action plan is prepared to include regional laws of Ethiopia. Other legal information including amendments to the laws, decisions and legal news will also be included on the site, hence a comprehensive Ethiopian Legal Web Portal will be developed and maintained. Key Words: Legal Information, Legal Information Website, Digital Divide | [
"Industrial and Manufacturing Engineering",
"Environmental Engineering"
] | |
[Front cover] | IEEE Transactions on Pattern Analysis and Machine Intelligence | [
"Applied Mathematics",
"Artificial Intelligence",
"Computational Theory and Mathematics",
"Computer Vision and Pattern Recognition",
"Software"
] | |
Impacto de um programa de reabilitação respiratória nos autocuidados higiene, vestir-se/despir-se e andar avaliados pela escala London Chest of Daily Living em pessoas com doença respiratória crónica | As pessoas com doença respiratória crónica (DRC) apresentam compromissos do processo respiratório, com elevado impacto no autocuidado, designadamente devido a dispneia e cansaço decorrente da imobilidade induzida pela doença. Torna-se, assim relevante conhecer qual o impacto dos programas de reabilitação respiratória (PRR) nos autocuidados higiene, vestir/despir-se e andar. Trata-se de um estudo quasiexperimental, que incluiu pessoas com DRC admitidas para PRR, sendo o impacto da DRC nos autocuidados avaliado no inicio e no final do PRR. Foram incluídas 38 pessoas (71,9% homens), mediana de idades 67 anos (±15.6) e FEV1% mediano de 39,51%. Encontradas melhorias estatística (p | [
"Microbiology (medical)",
"Immunology",
"Immunology and Allergy"
] | |
Birefringence Measurement for Magnetic Fluid Film Using Optical Fiber System | [
"Electrical and Electronic Engineering",
"Atomic and Molecular Physics, and Optics",
"Electronic, Optical and Magnetic Materials"
] | ||
Pharmacy patron perspectives of community pharmacist administered influenza vaccinations | [
"Pharmaceutical Science",
"Pharmacy"
] | ||
An aromatic Ca2B8 complex for reversible hydrogen storage | [
"Energy Engineering and Power Technology",
"Condensed Matter Physics",
"Fuel Technology",
"Renewable Energy, Sustainability and the Environment"
] | ||
NATIONAL ACCOUNTS AND NATIONAL INCOME IN THE UNION OF SOUTH AFRICA SINCE 1933 | [
"Economics and Econometrics"
] | ||
Nutritional Problems of Developing Countries | [
"Infectious Diseases",
"Microbiology (medical)"
] | ||
Masthead | [
"Energy Engineering and Power Technology",
"Fuel Technology",
"Nuclear Energy and Engineering",
"Renewable Energy, Sustainability and the Environment"
] | ||
Case Study | SO YOU MISSED YOUR RIDE HOME BECAUSE THE HOSPITAL SCREWED UP your outpatient appointment? Don't worry. Chances are a smiling hospital employee will give you cab fare home. Miss a hospital meal because you got stuck down in radiology? No problem. You might get your own special meal to make up for it. Unhappy with your stay? In all likelihood, your case was the exception. The hospital is sorry, and they might just say it with flowers. | [
"Strategy and Management",
"Management Information Systems"
] | |
Surfactant-Impregnated MOF-Coated Fabric for Antimicrobial Applications | [
"Biochemistry (medical)",
"Biomedical Engineering",
"Biomaterials"
] | ||
A survey of notified travel-associated infections: implications for travel health advice | [
"Public Health, Environmental and Occupational Health"
] | ||
Novel treatment protocol for ameliorating refractory, chronic pain in patients with autosomal dominant polycystic kidney disease | Kidney International | [
"Nephrology"
] | |
Assessment of Heavy Metals Contamination and Potential Ecological Risk in Soils Affected by a Former Mn Mining Activity, Drama District, Northern Greece | [
"Health, Toxicology and Mutagenesis",
"Pollution",
"Soil Science",
"Environmental Chemistry"
] | ||
Extracorporeal photopheresis affects interleukin (IL)-10 and IL-12 production by monocytes in patients with chronic graft-versus-host disease | [
"Dermatology"
] | ||
Bounding the number of segment histories during data race detection | [
"Artificial Intelligence",
"Computer Graphics and Computer-Aided Design",
"Computer Networks and Communications",
"Hardware and Architecture",
"Theoretical Computer Science",
"Software"
] | ||
The field induced in a two-layer medium by an arbitrary source | Geophysical Journal International | [
"Geochemistry and Petrology",
"Geophysics"
] |
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