Title stringlengths 0 905 | Abstract stringlengths 0 11.3k | Container_Title stringlengths 0 126 | Subject listlengths 1 13 |
|---|---|---|---|
Correction. Reciprocal Solubility of the Normal Propyl Ethers of 1,2-Propylene Glycol and Water | [
"Colloid and Surface Chemistry",
"Biochemistry",
"Catalysis"
] | ||
Studies of the interaction of psychological and pharmacological determinants of smoking. | [
"Developmental Neuroscience",
"Experimental and Cognitive Psychology"
] | ||
Growth, maturation, and physical activity, 2nd edition | [
"Genetics",
"Anthropology",
"Ecology, Evolution, Behavior and Systematics",
"Anatomy"
] | ||
Die Anwendung von Aktivitätsgrakienten in der Dünnschichtchromatographie | Helvetica Chimica Acta | [
"Inorganic Chemistry",
"Organic Chemistry",
"Physical and Theoretical Chemistry",
"Drug Discovery",
"Biochemistry",
"Catalysis"
] | |
Two-loop QCD renormalization and anomalous dimension of the scalar diquark operator | [
"Nuclear and High Energy Physics"
] | ||
Paper 11: Training for Management | The paper emphasizes the importance of management in engineering and states the need for formalized education and training in management today. The content of some of the courses, seminars, and conferences covered at the English Electric Staff Training Centre at Dunchurch is then discussed together with some of the projects and exercises used. Some of the difficulties of running such a centre and ascertaining the real training needs are then mentioned. The importance of evaluation on a proper feedback basis by the use of management-by-objectives principles is also considered. | [
"Cell Biology",
"Developmental Biology",
"Embryology",
"Anatomy"
] | |
Additions to Symplocaceae of the Old World Including New Caledonia | [
"Plant Science",
"Ecology, Evolution, Behavior and Systematics"
] | ||
Back Matter | [
"Ecology, Evolution, Behavior and Systematics"
] | ||
A Button for Gastrostomy Feedings | [
"Maternity and Midwifery",
"Pharmacology (nursing)"
] | ||
ZnO nanocontainers: structural study and controlled release | [
"Materials Chemistry"
] | ||
Surveillance of drugs that most frequently induce acute kidney injury: A pharmacovigilance approach | [
"Pharmacology (medical)",
"Pharmacology"
] | ||
Prevention and Management of COVID-19-Associated Venous Thromboembolism | Распространение новой коронавирусной инфекции SARS-CoV-2, классифицируемой сейчас как COVID-19, приобрело глобальный характер. Врачи, занимающиеся лечением пациентов с COVID-19, ежедневно сталкиваются с новыми и неожиданными проблемами. Коронавирусная болезнь может быть причиной системной коагулопатии и тромботических осложнений. Недавние исследования подтвердили крайне высокую частоту встречаемости тромбоэмболических событий, в особенности в группе пациентов с тяжелым течением коронавирусной пневмонии. Сепсис-индуцированная активация коагуляционного каскада в сочетании с широкой распространенностью в общей популяции известных факторов риска венозной тромбоэмболии (ВТЭ) способствуют развитию в организме протромботического статуса. Аномальные параметры коагуляции связаны с плохим прогнозом для пациентов с COVID-19-пневмонией. Определенные гематологические биомаркеры, включая D-димер, могут выступать в качестве предикторов тромботических событий и неблагоприятных исходов заболевания. Вероятность развития тромботических осложнений следует определять у всех пациентов с COVID-19, которые входят в группу высокого риска ВТЭ и имели несколько неблагоприятных факторов до начала коронавирусной инфекции (более 8 баллов по шкале Caprini). В случаях развития сепсис-индуцированной коагулопатии антикоагулянтная терапия, по-видимому, связана с лучшим прогнозом в отношении смертности. Уровень D-димера может служить показателем эффективности антикоагулянтной терапии, однако такой подход не является общепринятым. В настоящем обзоре литературы обобщены накопленные на сегодняшний день эпидемиологические данные и текущие рекомендации по профилактике и лечению COVID-19-ассоциированной ВТЭ. Дальнейшие исследования должны быть сосредоточены на разработке оптимальных стратегий диагностики и профилактики COVID-19-ассоциированной ВТЭ и связанной с ней летальности The disease caused by coronavirus SARS-CoV-2, named CoViD-19, has become a global emergency. Physicians that treat patients with COVID-19 face new and unexpected challenges every day. COVID-19 can lead to systemic coagulation activation and thrombotic complications. Recent studies confirmed very high cumulative incidence of thromboembolic events, particularly in critically illpatients with COVID-19 pneumonia. The sepsis-related activation of the coagulation combined with high prevalence of common thrombotic risk factors can contribute to this prothrombotic state. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. Coagulation biomarkers, including D-dimer, can help in the identification of patients with the risk of complications and mortality. D-dimers may be used to monitor the effectiveness of anticoagulants, although this practice is not universally accepted. Risk assessment in admission is important to identify high-risk patients with multiple risk factors before the onset of the viral infection (Caprini score >8). In case of sepsis-induced coagulopathy, anticoagulant therapy appears to be associated with better prognosis in relation to mortality. In this review, we summarize available epidemiological data on venous thromboembolism and recommendations on thromboprophylaxis in COVID-19. Future research should focus on optimal diagnostic and prophylactic strategies to prevent VTE and potentially improve survival. | [
"Cardiology and Cardiovascular Medicine"
] | |
Effects of a natural multi‑component compound formulation on the growth, morphology and extracellular matrix production of human adult dermal fibroblasts | Experimental and Therapeutic Medicine | [
"Cancer Research",
"Immunology and Microbiology (miscellaneous)"
] | |
A car-use mini disc (MD) changer | IEEE Transactions on Consumer Electronics | [
"Electrical and Electronic Engineering",
"Media Technology"
] | |
[2+2+2] Cycloaddition Reactions of Macrocyclic Systems Catalyzed by Transition Metals. A Review | [
"Chemistry (miscellaneous)",
"Analytical Chemistry",
"Organic Chemistry",
"Physical and Theoretical Chemistry",
"Molecular Medicine",
"Drug Discovery",
"Pharmaceutical Science"
] | ||
Pure intra mode decision in HEVC using optimized firefly algorithm | [
"Electrical and Electronic Engineering",
"Computer Vision and Pattern Recognition",
"Media Technology",
"Signal Processing"
] | ||
Leadership characteristics and practices in schools with different effectiveness and improvement profiles | [
"Strategy and Management",
"Arts and Humanities (miscellaneous)",
"Education"
] | ||
EXPRESSION OF TRANSFORMING GROWTH FACTOR-ALPHA, EPIDERMAL GROWTH-FACTOR RECEPTOR AND PROLIFERATING CELL NUCLEAR ANTIGEN IN GASTRIC-CARCINOMA - AN IMMUNOHISTOCHEMICAL STUDY | International Journal of Oncology | [
"Cancer Research",
"Oncology"
] | |
Abstract 5240: Functional and therapeutic significance of ESR1 gene fusions in breast cancer | Abstract RNA sequencing detects estrogen receptor alpha gene (ESR1) fusion transcripts in estrogen receptor positive (ER+) breast cancer but their role in disease pathogenesis remains unclear. Herein we examined multiple in-frame and out-of-frame ESR1 fusions and found only two, both identified in advanced endocrine treatment resistant disease, encoded stable and functional in-frame fusion proteins. In both examples, ESR1-e6>YAP1 and ESR1-e6>PCDH11X, the N-terminal, DNA binding and dimerization motifs encoded by exons 2-6 were fused to C-terminal sequences from the partner gene. Functional properties included estrogen-independent growth, constitutive expression of ER target genes, anti-estrogen resistance, induction of cellular motility in vitro and the development of lung metastasis in vivo. Chromatin immunoprecipitation and RNA sequencing experiments showed both fusions uniquely activated a metastasis-associated transcriptional program. ESR1-e6>YAP1 and ESR1-e6>PCDH11X-induced growth remained sensitive to a CDK4/6 inhibitor, palbociclib, and a patient-derived xenograft (PDX) expressing the ESR1-e6>YAP1 fusion was also responsive. Transcriptionally active ESR1 fusions therefore trigger both endocrine therapy resistance and metastatic progression explaining the association with fatal disease progression, although CDK4/6 inhibitor treatment is predicted to be effective. Citation Format: Jonathan T. Lei, Jieya Shao, Jin Zhang, Michael Iglesia, Doug W. Chan, Jin Cao, Meenakshi Anurag, Purba Singh, Xiaping He, Yoshimasa Kosaka, Ryoichi Matsunuma, Robert Crowder, Jeremy Hoog, Chanpheng Phommaly, Rodrigo Goncalves, Susana Romalho, Raquel M. Peres, Nindo Punturi, Cheryl Schmidt, Alex Bartram, Eric Jou, W V. Lai, Oliver Hampton, Anna Rogers, Ethan Tobias, Poojan Parikh, Sherri R. Davies, Shunqiang Li, Cynthia X. Ma, Vera Suman, Kelly K. Hunt, Mark A. Watson, Katherine A. Hoadley, E A. Thompson, Xi Chen, Shyam M. Kavuri, Chad J. Creighton, Christopher A. Maher, Charles M. Perou, Svasti Haricharan, Matthew J. Ellis. Functional and therapeutic significance of ESR1 gene fusions in breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 5240. | Cancer Research | [
"Cancer Research",
"Oncology"
] |
A comparison of the characteristics, motivations, preferences and expectations of men donating sperm online or through a sperm bank | Abstract STUDY QUESTION How do the demographic characteristics, motivations, experiences and expectations of unregulated sperm donors (men donating sperm online through a connection website) compare to sperm donors in the regulated sector (men donating through a registered UK sperm bank)? SUMMARY ANSWER Online donors were more likely to be older, married and have children of their own than sperm bank donors, were more varied in their preferences and expectations of sperm donation, and had more concerns about being a sperm donor. WHAT IS KNOWN ALREADY While studies have examined motivations and experiences of both regulated sperm bank, and unregulated online sperm donors, no study has directly compared these two groups of donors. STUDY DESIGN, SIZE, DURATION An email was sent to the 576 men who were registered sperm donors at the London Sperm Bank, the UK’s largest sperm bank regulated by the Human Fertilisation and Embryology Authority (HFEA), who had commenced donation between January 2010 and December 2016, and had consented to be contacted for research. The online survey, which contained multiple choice and open-ended questions, was completed by 168 men over a 7-week period. The responses were compared to those of sperm donors registered on Pride Angel, a large UK-based connection website for donors and recipients of sperm: our research team had already collected these data. In total, 5299 sperm donors were on Pride Angel at time of data capture and 400 men had completed a similar survey. The responses of 70 actual online sperm donors (i.e. those whose sperm had been used to conceive at least one child) were used for comparison with the sperm bank donors. PARTICIPANTS/MATERIALS, SETTING, METHODS The survey obtained data on the sperm donors’ demographic characteristics, motivations, experiences and expectations of sperm donation. Data from sperm bank donors were compared to online donors to examine differences between the two groups. The study compared online and clinic donors who had all been accepted as sperm donors: online donors who had been ‘vetted’ by recipients and sperm bank donors who had passed the rigorous screening criteria set by the clinic. MAIN RESULTS AND THE ROLE OF CHANCE A response rate of 29% was obtained from the sperm bank donors. Online donors were significantly older than sperm bank donors (mean ± SD: 38.7 ± 8.4 versus 32.9 ± 6.8 years, respectively) and were more likely to have their own children (p < 0.001 for both characteristics). Both groups rated the motivation ‘I want to help others’ as very important. Online donors rated ‘I don’t want to have children myself’, ‘to have children/procreate’ and ‘to enable others to enjoy parenting as I have myself’ as more important than sperm bank donors, whereas sperm bank donors rated financial payment as more important than online donors, as well as confirmation of own fertility. Most (93.9%) online donors had donated their sperm elsewhere, through other connection sites, fertility clinics, sperm banks or friends and family, compared to only 2.4% of sperm bank donors (p < 0.001). There was a significant difference in how donors viewed their relationship to the child, with online donors much less likely than sperm bank donors to see their relationship as a ‘genetic relationship only’. Online donors had more concerns about being a donor (p < 0.001), for example, being concerned about ‘legal uncertainty and child financial support’ and ‘future contact and uncertainty about relationship with donor-conceived child’. LIMITATIONS, REASONS FOR CAUTION Findings may not be representative of all sperm donors as only one online connection site and one HFEA registered sperm bank were used for recruitment. WIDER IMPLICATIONS OF THE FINDINGS Despite concern regarding shortages of sperm donors in licensed clinics and unease regarding the growing popularity of unregulated connection websites, this is the first study to directly compare online and sperm bank donors. It highlights the importance of considering ways to incorporate unregulated online sperm donors into the regulated sector. With many online donors well aware of the legal risks they undertake when donating in the unregulated online market, this would both increase the number of sperm donors available at clinics but also provide legal protection and support for donors. STUDY FUNDING/COMPETING INTEREST(S) This study was supported by the Wellcome Trust Grants 104 385/Z/14/Z and 097857/Z/11/Z. The authors have no conflicts of interest. | [
"Obstetrics and Gynecology",
"Rehabilitation",
"Reproductive Medicine"
] | |
Développement d’un algorithme de prédiction personnalisé de l’évolution de la sévérité de la dermatite atopique | Annales de Dermatologie et de Vénéréologie - FMC | [
"Ocean Engineering",
"Safety, Risk, Reliability and Quality"
] | |
Ueber die Constitution des Radicals C 3 H 5 in dem Eugenol und Anethol | [
"Inorganic Chemistry"
] | ||
Providing Environmental Science Services | [
"Marketing",
"Public Administration",
"Sociology and Political Science"
] | ||
Implementation of Discontinuous Skeletal methods on arbitrary-dimensional, polytopal meshes using generic programming | [
"Applied Mathematics",
"Computational Mathematics"
] | ||
Assessment of Genetic Stability on In Vitro Propagation of Ardisia crenata var. bicolor Using ISSR Markers | Ardisia crenata var. bicolor is a multi-purpose plant and has important ornamental and medicinal properties. Conventional methods of propagating the species from seeds and cuttings have low efficiency because of the recalcitrant properties of seeds and low survival rate of high-quality cuttings. This work aims to study the in vitro regeneration protocol for direct organogenesis from nodal segments of A. crenata var. bicolor on Murashige and Skoog (MS) medium, with different combinations and concentrations of plant growth regulators (PGRs). The treatments used for the establishment and proliferation of shoots included MS medium supplemented with different concentrations of Benzyl-aminopurine (BAP) and indole-3-butyric acid (IBA). For rooting, IBA was used in combination with naphthaleneacetic acid (NAA) in full- and half-strength MS media. Maximum shoot establishment (76.67%) and the highest shoot length (6.6 cm) were observed on MS medium with 1.0 mg·L−1 BAP with 0.5 mg·L−1 IBA, while BAP at 1.0 mg·L−1 with 0.25 mg·L−1 IBA obtained the highest shoot proliferation (4.5 ± 1.53). The best rooting response (83.33%) was achieved on half-strength MS including 1.0 mg·L−1 IBA with 0.25 mg·L−1 NAA, and the maximum survival rate of 84.4% was observed after acclimatization under 75% shading. To define their genetic stability, using eleven primers of ISSR markers to assess the genetic stability of the unstable leaf color samples compared with their mother plant, the ISSR markers demonstrated a level of genetic polymorphism in plantlets, but without other morphological variations. This indicates the genetic resemblance to the mother plant and the reliability of this protocol for the efficient micropropagation of A. crenata var. bicolor. | [
"Plant Science"
] | |
Respiratory depression in the acute management of seizures | [
"Pediatrics, Perinatology and Child Health"
] | ||
Mise en place de la cohorte Constances. Premiers résultats de la phase pilote | [
"Public Health, Environmental and Occupational Health",
"Epidemiology"
] | ||
Transition from fetus to neonate | [
"Surgery"
] | ||
Venous Thromboembolism Prophylaxis: Patients at High Risk to Fail Intermittent Pneumatic Compression | Obstetrical & Gynecological Survey | [
"Obstetrics and Gynecology"
] | |
Accuracy of electroanatomical mapping-guided cardiac radiotherapy for ventricular tachycardia: pitfalls and solutions | Abstract Aims To analyse and optimize the interobserver agreement for gross target volume (GTV) delineation on cardiac computed tomography (CCT) based on electroanatomical mapping (EAM) data acquired to guide radiotherapy for ventricular tachycardia (VT). Methods and results Electroanatomical mapping data were exported and merged with the segmented CCT using manual registration by two observers. A GTV was created by both observers for predefined left ventricular (LV) areas based on preselected endocardial EAM points indicating a two-dimensional (2D) surface area of interest. The influence of (interobserver) registration accuracy and availability of EAM data on the final GTV and 2D surface location within each LV area was evaluated. The median distance between the CCT and EAM after registration was 2.7 mm, 95th percentile 6.2 mm for observer #1 and 3.0 mm, 95th percentile 7.6 mm for observer #2 (P = 0.9). Created GTVs were significantly different (8 vs. 19 mL) with lowest GTV overlap (35%) for lateral wall target areas. Similarly, the highest shift between 2D surfaces was observed for the septal LV (6.4 mm). The optimal surface registration accuracy (2.6 mm) and interobserver agreement (Δ interobserver EAM surface registration 1.3 mm) was achieved if at least three cardiac chambers were mapped, including high-quality endocardial LV EAM. Conclusion Detailed EAM of at least three chambers allows for accurate co-registration of EAM data with CCT and high interobserver agreement to guide radiotherapy of VT. However, the substrate location should be taken in consideration when creating a treatment volume margin. | [
"Physiology (medical)",
"Cardiology and Cardiovascular Medicine"
] | |
Crystal structure of I III IV Se4 compounds | [
"Condensed Matter Physics",
"Electronic, Optical and Magnetic Materials"
] | ||
IMEX Large Time Step Finite Volume Methods for Low Froude Number Shallow Water Flows | AbstractWe present new large time step methods for the shallow water flows in the low Froude number limit. In order to take into account multiscale phenomena that typically appear in geophysical flows nonlinear fluxes are split into a linear part governing the gravitational waves and the nonlinear advection. We propose to approximate fast linear waves implicitly in time and in space by means of a genuinely multidimensional evolution operator. On the other hand, we approximate nonlinear advection part explicitly in time and in space by means of the method of characteristics or some standard numerical flux function. Time integration is realized by the implicit-explicit (IMEX) method. We apply the IMEX Euler scheme, two step Runge Kutta Cranck Nicolson scheme, as well as the semi-implicit BDF scheme and prove their asymptotic preserving property in the low Froude number limit. Numerical experiments demonstrate stability, accuracy and robustness of these new large time step finite volume schemes with respect to small Froude number. | [
"Physics and Astronomy (miscellaneous)"
] | |
Investigation of physico-chemical degradation through weathering acceleration of hemp/PLA biocomposite: thermal analysis | Journal of Thermal Analysis and Calorimetry | [
"Physical and Theoretical Chemistry",
"Condensed Matter Physics"
] | |
Growing Teratoma Syndrome and Gliomatosis Peritonei in a 15-Year-Old Girl With Immature Ovarian Teratoma: Case Report and Review of the Literature | [
"Obstetrics and Gynecology",
"Pediatrics, Perinatology and Child Health"
] | ||
Abstract P6-16-06: Twitter chats: Utilizing an innovative technology platform to offer education and tools to people with breast cancer | Abstract Background. The use of social media for health information and peer support has grown significantly over time. According a 2015 study from the Pew Research Center, 65 percent of U.S. adults utilize social media, up from 7 percent a decade earlier. A 2014 study reported 72 percent of adult internet users search online for health information, often focused on specific diseases or treatments, with 16 percent seeking others with similar health concerns. Twitter, a popular social media platform for information- and support-seekers, grew from 54 million monthly active users in 2010 to approximately 241 million in 2013. To address the growing use of Twitter as an information and support portal, Living Beyond Breast Cancer (LBBC) decided to pilot a Twitter chat in 2014. The goals for the chat were to: (1) increase understanding of a breast cancer concern; (2) connect impacted individuals to one another in a supportive and safe online space; (3) offer practical resources for further exploration; and (4) increase LBBC's reach online among users interested in breast cancer. Methods. LBBC staff researched best practices for Twitter chats. The topic of triple-negative breast cancer (TNBC) was chosen for LBBC's pilot program to coincide with Triple Negative Breast Cancer Awareness Day. The staff developed 7 questions and 10 alternates to deliver over 60 minutes. Using publicly available data from Symplur, hashtags were considered and developed. A panel was recruited of one medical oncologist, two advocates, and two women with TNBC. Panelists were encouraged to prepare Tweets in advance and, during the chat, to use assigned hashtags, correct medical inaccuracies, and attend to emotional concerns among chat participants. LBBC staff developed resource-rich tweets. The program was promoted over social media channels. At the end of the chat, participants were offered an incentivized opportunity to evaluate the program via a URL link to LBBC's existing survey instrument. Results. Using the #TNBCchat hashtag, the March 3, 2014, program and activity the next week produced 234 tweets from 127 contributors, reaching 198,985 accounts. Participants wrote 118 tweet replies and retweeted 291 comments. Questions covered the definition of and treatments for TNBC, differences between metastatic and early-stage disease, unique emotional concerns, and methods to reduce recurrence risk. The three most popular tweets promoted the program, introduced panelists, and shared resources about PARP inhibitors. Encouraged by the pilot program's reach and results, LBBC has delivered 20 Twitter chats as of June 2018. Topics have included nutrition, parenting, caregiving, and breast reconstruction. Over time, LBBC staff has refined the program model with the goals of increasing engagement, delivering more useful content, and driving users toward the evaluation. Conclusions. Twitter chats allow nonprofit organizations to inexpensively utilize innovative technology to provide educational information to and foster a community of support among people impacted by breast cancer. By utilizing core organizational principles of appropriate program delivery, LBBC delivers practical content that may improve the quality of life of users in distant locations. Citation Format: Guglielmino JE, Ormerod CL, Grillo AB, Sood SA. Twitter chats: Utilizing an innovative technology platform to offer education and tools to people with breast cancer [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr P6-16-06. | [
"Cancer Research",
"Oncology"
] | |
A combined synchronization index for evaluating collective action social media | AbstractSocial media has provided a citizen voice, giving rise to grassroots collective action, where users deploy a concerted effort to disseminate online narratives and even carry out offline protests. Sometimes these collective action are aided by inorganic synchronization, which arise from bot actors. It is thus important to identify the synchronicity of emerging discourse on social media and the indications of organic/inorganic activity within the conversations. This provides a way of profiling an event for possibility of offline protests and violence. In this study, we build on past definitions of synchronous activity on social media— simultaneous user action–and develop a Combined Synchronization Index (CSI) which adopts a hierarchical approach in measuring user synchronicity. We apply this index on six political and social activism events on Twitter and analyzed three action types: synchronicity by hashtag, URL and @mentions.The CSI provides an overall quantification of synchronization across all action types within an event, which allows ranking of a spectrum of synchronicity across the six events. Human users have higher synchronous scores than bot users in most events; and bots and humans exhibits the most synchronized activities across all events as compared to other pairs (i.e., bot-bot and human-human). We further rely on the harmony and dissonance of CSI-Network scores with network centrality metrics to observe the presence of organic/inorganic synchronization. We hope this work aids in investigating synchronized action within social media in a collective manner. | Applied Network Science | [
"Computational Mathematics",
"Computer Networks and Communications"
] |
Using anterior segment optical coherence tomography to compare the smoothness of anterior iris surface between two eyes in unilateral Fuchs’ uveitis syndrome | [
"Cellular and Molecular Neuroscience",
"Sensory Systems",
"Ophthalmology"
] | ||
La glyptique d'Oc-ēo | [
"Archeology",
"History"
] | ||
Fast multigrid solvers for conforming and non-conforming multi-patch Isogeometric Analysis | [
"Computer Science Applications",
"Mechanical Engineering",
"Mechanics of Materials",
"Computational Mechanics"
] | ||
Modulating the electronic and magnetic structures of P-doped graphene by molecule doping | Journal of Physics: Condensed Matter | [
"Condensed Matter Physics"
] | |
A continuous Leontief dynamic input-output model | Papers of the Regional Science Association | [
"Environmental Science (miscellaneous)",
"Geography, Planning and Development"
] | |
Post anterior rectal resection syndrome - a retrospective multicentre study | [
"Gastroenterology"
] | ||
National Constitutional Courts in supranational litigation: A contextual analysis | [
"Law"
] | ||
In vivo carotid plaque MRI using quantitative T 2 * measurements with ultrasmall superparamagnetic iron oxide particles: a dose-response study to statin therapy | [
"Spectroscopy",
"Radiology, Nuclear Medicine and Imaging",
"Molecular Medicine"
] | ||
Buchbesprechung | [
"Animal Science and Zoology"
] | ||
The Politics of Nationalizing Curricular Content | American Journal of Education | [
"Education"
] | |
Active Control Algorithms for the Control of Rotor Vibrations Using Hybrid Squeeze Film Dampers | The hybrid squeeze film damper (HSFD) has proven itself to be an effective controlling device of vibration in rotating machinery. The critical stage in the development of the HSFD as an active vibration suppressant, is the development of the control algorithms for active control of rotor vibrations. This paper summarizes, evaluates, and compares the control algorithms for HSFD-supported rotors. Quantitative as well as qualitative measures of the effectiveness of the control algorithms are presented. The study includes the PID-type controllers, LQR, gain scheduling, adaptive and bang-bang controllers. The adaptive, gain scheduling, and nonlinear proportional controllers have proved to be quite effective in the active control of HSFD supported rotors, with impressive results. | [
"Mechanical Engineering",
"Energy Engineering and Power Technology",
"Aerospace Engineering",
"Fuel Technology",
"Nuclear Energy and Engineering"
] | |
Musculoskeletal Care | [
"Nursing (miscellaneous)",
"Rehabilitation",
"Physical Therapy, Sports Therapy and Rehabilitation",
"Orthopedics and Sports Medicine",
"Chiropractics",
"Rheumatology"
] | ||
Sequelae After Involution of Superficial Infantile Hemangioma: Early Intervention with 595-nm Pulsed Laser Combined with 755-nm Long-Pulsed Alexandrite Laser versus Wait-and-See | [
"Dermatology"
] | ||
PD28-08 A DOUBLE-BLIND, PLACEBO-CONTROLLED PARALLEL GROUP STUDY TO EVALUATE THE EFFECT OF A SINGLE ORAL DOSE OF GSK958108 ON EJACULATION LATENCY TIME IN MALE PATIENTS SUFFERING FROM PREMATURE EJACULATION | [
"Urology"
] | ||
SigMod: an exact and efficient method to identify a strongly interconnected disease-associated module in a gene network | Abstract Motivation Apart from single marker-based tests classically used in genome-wide association studies (GWAS), network-assisted analysis has become a promising approach to identify a set of genes associated with disease. To date, most network-assisted methods aim at finding genes connected in a background network, whatever the density or strength of their connections. This can hamper the findings as sparse connections are non-robust against noise from either the GWAS results or the network resource. Results We present SigMod, a novel and efficient method integrating GWAS results and gene network to identify a strongly interconnected gene module enriched in high association signals. Our method is formulated as a binary quadratic optimization problem, which can be solved exactly through graph min-cut algorithms. Compared to existing methods, SigMod has several desirable properties: (i) edge weights quantifying confidence of connections between genes are taken into account, (ii) the selection path can be computed rapidly, (iii) the identified gene module is strongly interconnected, hence includes genes of high functional relevance, and (iv) the method is robust against noise from either the GWAS results or the network resource. We applied SigMod to both simulated and real data. It was found to outperform state-of-the-art network-assisted methods in identifying disease-associated genes. When SigMod was applied to childhood-onset asthma GWAS results, it successfully identified a gene module enriched in consistently high association signals and made of functionally related genes that are biologically relevant for asthma. Availability and implementation An R package SigMod is available at: https://github.com/YuanlongLiu/SigMod Supplementary information Supplementary data are available at Bioinformatics online. | [
"Computational Mathematics",
"Computational Theory and Mathematics",
"Computer Science Applications",
"Molecular Biology",
"Biochemistry",
"Statistics and Probability"
] | |
Foliar application of fertilizer based on proline and inosine stimulates the second flush growth of Italian ryegrass (Lolium multiflorum Lam.) | [
"Plant Science",
"Agronomy and Crop Science",
"Ecology, Evolution, Behavior and Systematics"
] | ||
Book Reviews | [
"Horticulture",
"Plant Science"
] | ||
Informationen aus Österreich | Manuelle Medizin | [
"Complementary and Alternative Medicine",
"Physical Therapy, Sports Therapy and Rehabilitation",
"Complementary and Manual Therapy"
] | |
An empirical analysis of the relationship of bond yield spreads and macro economic factors | [
"Economics and Econometrics",
"Finance"
] | ||
The risk of Barrett's esophagus associated with abdominal obesity in males and females | International Journal of Cancer | [
"Cancer Research",
"Oncology"
] | |
Ovarian Steroid Regulation of 5-HT1A Receptor Binding and G protein Activation in Female Monkeys | [
"Psychiatry and Mental Health",
"Pharmacology"
] | ||
IgE antibodies to food allergen extracts and to specific food proteins among 616 children in mid-childhood in an unselected birth cohort | [
"Immunology",
"Immunology and Allergy"
] | ||
Sense of responsibility in ICU end-of-life decision-making: Relatives’ experiences | Background: Relatives of intensive care unit patients who lack or have reduced capacity to consent are entitled to information and participation in decision-making together with the patient. Practice varies with legislation in different countries. In Norway, crucial decisions such as withdrawing treatment are made by clinicians, usually morally justified to relatives with reference to the principle of non-maleficence. The relatives should, however, be consulted about whether they know what the patient would have wished in the situation. Research objectives: To examine and describe relatives’ experiences of responsibility in the intensive care unit decision-making process. Research design: A secondary analysis of interviews with bereaved relatives of intensive care unit patients was performed, using a narrative analytical approach. Participants and research context: In all, 27 relatives of 21 deceased intensive care unit patients were interviewed about their experiences from the end-of-life decision-making process. Most interviews took place in the participants’ homes, 3–12 months after the patient’s death. Ethical considerations: Based on informed consent, the study was approved by the Data Protection Official of the Norwegian Social Science Data Services and by the Regional Committee for Medical and Health Research Ethics. Findings: The results show that intensive care unit relatives experienced a sense of responsibility in the decision-making process, independently of clinicians’ intention of sparing them. Some found this troublesome. Three different variants of participation were revealed, ranging from paternalism to a more active role for relatives. Discussion: For the study participants, the sense of responsibility reflects the fact that ethics and responsibility are grounded in the individual’s relationship to other people. Relatives need to be included in a continuous dialogue over time to understand decisions and responsibility. Conclusion: Nurses and physicians should acknowledge and address relatives’ sense of responsibility, include them in regular dialogue and help them separate their responsibility from that of the clinicians. | [
"Issues, Ethics and Legal Aspects"
] | |
Lipids from Seeds of Matricaria matricarioides | [
"Plant Science"
] | ||
Classification of functional abilities of children and adolescents with cerebral palsy | [
"Neurology (clinical)",
"Developmental Neuroscience",
"Pediatrics, Perinatology and Child Health"
] | ||
Aberrant p53 Staining Does Not Predict Cisplatin Resistance in Locally Advanced Non-Small Cell Lung Cancer | [
"Cancer Research",
"Oncology"
] | ||
Almost commuting pairs of unitary operators and flat currents | [
"Algebra and Number Theory",
"Analysis"
] | ||
Studies on the mechanisms of rootlet inhibition in developing barley embryos | [
"Biochemistry",
"Food Science"
] | ||
20. Ein Fall von progressiver Paralyse bei Mutter und Kind (A Case of General Paresis in Mother and Child) | [
"Psychiatry and Mental Health"
] | ||
Towards a Property Market Paradigm of Urban Change | Conventional treatments of urban change almost uniformly ignore the role of land and property markets as essential mediators of such change. The urban built environment is assumed to be a passive adapter to structural change. However, given the complexity of property market process—in particular the disparate nature of market actors, decision rules, and institutions, the immutable characteristics of property, and the obvious constraints imposed by the existing built environment—simple adaptive adjustment is unlikely to take place. These factors can themselves be expected to play an important part in shaping urban growth and development outcomes. In response to these concerns, we propose a property market paradigm of urban change and examine its relevance in the context of six major European urban regions. The results suggest that this approach can provide a more holistic understanding of contemporary urban change than that offered by conventional analysis. | [
"Environmental Science (miscellaneous)",
"Geography, Planning and Development"
] | |
A spontaneous mutation in the nicotinamide nucleotide transhydrogenase gene of C57BL/6J mice results in mitochondrial redox abnormalities | [
"Physiology (medical)",
"Biochemistry"
] | ||
Progress toward the Total Synthesis of Kalihinane Diterpenoids | [
"Organic Chemistry",
"Physical and Theoretical Chemistry",
"Biochemistry"
] | ||
The Dream of a New Social Order: Popular Magazines in America, 1893-1914. | [
"Sociology and Political Science",
"Anthropology",
"History"
] | ||
Varón con enfermedad renal crónica. ¿Normotenso? | [
"Gastroenterology",
"Community and Home Care"
] | ||
Variabilité et homogénéité des modes de débitage en Chine entre 300 000 et 50 000ans | [
"History and Philosophy of Science",
"Anthropology"
] | ||
Dehydroxylation of alcohols for nucleophilic substitution | The convenient dehydroxylative substitution of alcohols with various nucleophiles promoted by the Ph3P/ICH2CH2I system under mild conditions is described. | Chemical Communications | [
"Materials Chemistry",
"Metals and Alloys",
"Surfaces, Coatings and Films",
"Ceramics and Composites",
"Electronic, Optical and Magnetic Materials",
"Catalysis"
] |
Multiple Needle-Stick Injuries With Risk of Human Immunodeficiency Virus Exposure in a Primary School | [
"Infectious Diseases",
"Microbiology (medical)",
"Pediatrics, Perinatology and Child Health"
] | ||
Cinquante ans d'histoire : de l'Institut français de Beyrouth à l'Institut français d'archéologie du Proche-Orient | [
"Archeology",
"History"
] | ||
Simple and sensitive method for visual detection of temporal asymmetry of ultrashort laser pulses | [
"Atomic and Molecular Physics, and Optics"
] | ||
Impaired cardiac function following experimental spinal cord injury occurs due to the loss of descending sympathetic control and precedes structural remodeling | [
"Genetics",
"Molecular Biology",
"Biochemistry",
"Biotechnology"
] | ||
Getting in and Getting on in the Youth Labour Market: Governing Young People’s Employability in Regional Context. by PaulineLeonard and RachelWilde. Bristol University Press, UK, 2019, 160pp., ISBN: 978‐1529202298, Price 45.34, h/b. | [
"Management of Technology and Innovation",
"Organizational Behavior and Human Resource Management"
] | ||
The Pfitzinger Reaction. (Review) | [
"Organic Chemistry"
] | ||
To Avoid Unnecessary Red Tape: Vasily Tatishchev’s Proposals on Streamlining Court Proceedings | Vasily Tatishchev is known not only as an outstanding statesman, but also as a scientist who stood at the origin of many sciences. He gained fame as a legal scholar, an expert on the legislation of foreign countries and his homeland. Unlike any of his contemporaries, he reflected on the role of laws in the development of a country, formulated requirements for their content, raised the question of their codification, took the initiative to draft bills, and identified and prepared important legislative documents for publication. The previously unknown document presented in this article makes it possible to talk about Tatishchev’s attempt on behalf of the state to resolve another important issue, the remuneration of judges and clerical officers by introducing payments dependent on the total amount of the claim, the volume of prepared court documents, and their varieties. The author proves Tatishchev’s authorship in the development of such proposals, explaining the reasons for their appearance in terms of the upcoming reform of the plant management system based on bills developed by Tatishchev between 1734 and 1735: these were meant to regulate the relationship between the state and owners of private factories and the powers of the crown administration in state enterprises. The document adds to the existing idea of Tatishchev as a connoisseur of Russian legislation, his deep understanding of problems connected with the activities of judicial institutions, and his attempt to introduce remuneration principles enshrined in Swedish and German legislation into Russian legal practice. The implementation of these proposals would help expedite the adoption of judicial decisions and guarantee judges and clerical servants decent pay. The significance of the proposals formulated by Tatishchev cannot be overemphasised: there was hardly anyone else in Russia who was capable of offering a whole system of monetary compensation for those involved in organising court trials and drawing up documents, demonstrating deep detailed knowledge of judicial documentation. | [
"Literature and Literary Theory",
"Linguistics and Language",
"Visual Arts and Performing Arts",
"History",
"Language and Linguistics",
"Cultural Studies"
] | |
Thermodynamic properties of the kagome lattice in herbertsmithite | [
"Condensed Matter Physics",
"Electronic, Optical and Magnetic Materials"
] | ||
Does the amount of thyroglobulin antigen influence the severity and genetic control of murine autoimmune thyroiditis? | Immunology Letters | [
"Immunology",
"Immunology and Allergy"
] | |
Progress in the map world | 500 YEARS OF THE PRINTED MAP: a forthcoming exhibition at the British Museum, June—December 1972. | [
"Library and Information Sciences"
] | |
Safety and Tolerability of High-dose Weekly Liposomal Amphotericin B Antifungal Prophylaxis | [
"Infectious Diseases",
"Microbiology (medical)",
"Pediatrics, Perinatology and Child Health"
] | ||
Really Trying or Merely Trying | [
"Social Sciences (miscellaneous)",
"Health (social science)"
] | ||
Organizational barriers to transparency | Transparency in the activities of government and public service agencies has become a democratic sine qua non, legislated by access to information laws in many countries. While these laws have increased the amount of information available to the public, it is evident that numerous public organizations still try to conceal information, although no public or private interest of any importance justifies such behaviour. This article will develop a typology of these forms of behaviour which will allow for a better understanding of the origins of such dynamics and pave the way for a better evaluation of the point of equilibrium between administrative privilege and transparency. | [
"Public Administration",
"Sociology and Political Science"
] | |
Effectiveness of specific immunotherapy in the treatment of Hymenoptera venom hypersensitivity: A meta-analysis | [
"Pharmacology (medical)",
"Pharmacology"
] | ||
Cover Feature: Rational Development of Guanidinate and Amidinate Based Cerium and Ytterbium Complexes as Atomic Layer Deposition Precursors: Synthesis, Modeling, and Application (Chem. Eur. J. 15/2021) | [
"Catalysis",
"Organic Chemistry"
] | ||
Multilevel luminescence of Er3+/Pr3+ co-doped Ca2Nb2O7 ceramics and composite films for optical anti-counterfeiting | Ceramics International | [
"Materials Chemistry",
"Surfaces, Coatings and Films",
"Process Chemistry and Technology",
"Ceramics and Composites",
"Electronic, Optical and Magnetic Materials"
] | |
A New Cold War? Missile Defenses, Nuclear Arms Reductions, and Cyber War | [
"Political Science and International Relations"
] | ||
Development of spruce (Picea abies [L.] Karst.) target (crop) trees in pole-stage stand with different initial spacing and tending regime | [
"Soil Science",
"Forestry"
] | ||
Treatment outcomes of adult osteosarcoma in Srinagarind Hospital | [
"Oncology",
"Hematology"
] | ||
Kinetics of reversible surface crystallization and melting in poly(ethylene oxide): Effect of crystal thickness observed in the dynamic heat capacity | [
"Surfaces and Interfaces",
"Biophysics",
"Biotechnology"
] | ||
Cultivation of the Dible MushroomLentinula edodes (Shiitake) in Pasteurized Wheat Straw– Alternative Use of Georthermal Energy in Mexico | Engineering in Life Sciences | [
"Bioengineering",
"Environmental Engineering",
"Biotechnology"
] | |
Iatrogenic ruptures of the tracheobronchial tree | [
"Pulmonary and Respiratory Medicine"
] | ||
Numerical Solution of the Time Dependent Emden-Fowler Equations with Boundary Conditions using Modified Decomposition Method | Applied Mathematics & Information Sciences | [
"Applied Mathematics",
"Computational Theory and Mathematics",
"Computer Science Applications",
"Numerical Analysis",
"Analysis"
] | |
JOURNAL OF THE ILLUMINATING ENGINEERING INSTITUTE OF JAPAN, Journal of the Illuminating Engineering Institute of Japan | [
"Electrical and Electronic Engineering"
] | ||
Zero-Delay Mechanical Thrombectomy for Distal Large Vessel Occlusion Detected on Intraoperative Angiogram After Microsurgical Clipping of a Posterior Communicating Artery Aneurysm: Value of Hybrid Operating Room | [
"Neurology (clinical)",
"Surgery"
] | ||
Untersuchungen zum Einfluß des Gehaltes an pflanzlichem Rohprotein in der Ration auf die Verwertung von Harnstoff bei der Milchkuh | [
"Animal Science and Zoology"
] | ||
The Gonad-Brain Relationship: Effects of Female Sex Hormones on Electroshock Convulsions in the Rat | [
"Endocrinology"
] | ||
Wound healing activity of Azadirachta indica A. juss stem bark in mice | [
"Drug Discovery",
"Pharmaceutical Science"
] |
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