Title stringlengths 0 905 | Abstract stringlengths 0 11.3k | Container_Title stringlengths 0 126 | Subject listlengths 1 13 |
|---|---|---|---|
Mobile gamma-irradiation robot | Radiation Physics and Chemistry | [
"Radiation"
] | |
Studien über ein Salz des β-Pyridons und einiger Nicotinsäurederivate in ihrer Wirkung auf den Uterus | Archiv für Gynäkologie | [
"Obstetrics and Gynecology"
] | |
Issue Information - TOC | [
"Oncology"
] | ||
Teleshopping or store shopping? A choice model for forecasting the use of new telecommunications-based services | Environment and Planning B: Planning and Design | [
"Geography, Planning and Development"
] | |
On the hydrogen-ion concentration and some related properties of normal human blood1 | [
"Physiology"
] | ||
Systematic study on the solubilization of phospholipid vesicles by various surfactants | Journal of Colloid and Interface Science | [
"Colloid and Surface Chemistry",
"Surfaces, Coatings and Films",
"Biomaterials",
"Electronic, Optical and Magnetic Materials"
] | |
The Impact of Taking Parental Leave on Fathers’ Participation In Childcare And Relationships With Children: Lessons from Sweden | [
"Sociology and Political Science",
"Development"
] | ||
The constitutional conditions and models of political party funding | Przegląd Prawa Konstytucyjnego | [
"Applied Mathematics"
] | |
The Case of the Disappearing Allergy Medications | Many commonly prescribed combination cough, cold, and allergy products have disappeared from pharmacy shelves. In 2011, the US Food and Drug Administration (FDA) took action to remove these products from the US marketplace. This article discusses why the medications are unavailable and how to determine if a product you intend to prescribe is a part of this FDA action. The available alternative antihistamine products are discussed. | [
"Pulmonary and Respiratory Medicine",
"Immunology and Allergy"
] | |
JAMES JOSEPH BUSS. Winning the West with Words: Language and Conquest in the Lower Great Lakes. | The American Historical Review | [
"Museology",
"Archeology",
"History"
] | |
Überlegungen zur Semantik von τεῦχος in der Verwaltungssprache der Papyri und Inschriften | Archiv für Papyrusforschung und verwandte Gebiete | [
"Archeology",
"History"
] | |
Type 2 diabetes mellitus—current therapies and the emergence of surgical options | [
"Endocrinology",
"Endocrinology, Diabetes and Metabolism"
] | ||
Branch Libraries and Discrete Collections | [
"Library and Information Sciences",
"Information Systems"
] | ||
Identification and functional characterization of the Aux/IAA gene VcIAA27 in blueberry | Plant Signaling & Behavior | [
"Plant Science"
] | |
A Natural Biomarker Deserving Attention | [
"Cardiology and Cardiovascular Medicine"
] | ||
The anomeric specificity of yeast galactokinase | [
"Molecular Biology",
"Biochemistry",
"Biophysics"
] | ||
A computational neurodegenerative disease progression score: Method and results with the Alzheimer's disease neuroimaging initiative cohort | [
"Cognitive Neuroscience",
"Neurology"
] | ||
A Fairytale | Appalachian Heritage | [
"Immunology and Allergy"
] | |
INTERNAL LABOUR MARKETS: EVIDENCE FROM TWO LARGE AUSTRALIAN EMPLOYERS | [
"Economics and Econometrics",
"History"
] | ||
The anti‐tumourigenic effect of ellagic acid in SKOV‐3 ovarian cancer cells entails activation of autophagy mediated by inhibiting Akt and activating AMPK | [
"Physiology (medical)",
"Pharmacology",
"Physiology"
] | ||
Hydrochemistry of groundwater in the Savelugu–Nanton District, Northern Ghana | Environmental Earth Sciences | [
"Earth-Surface Processes",
"Geology",
"Pollution",
"Soil Science",
"Water Science and Technology",
"Environmental Chemistry",
"Global and Planetary Change"
] | |
Within-season grass herbage crude-protein- and nitrate-N concentrations as affected by rates and seasonal distribution of fertilizer nitrogen in a high yearly rainfall climate | An orchardgrass study in which three rates of N (100, 200 and 400 kg ha−1) each distributed in 1/0/0/0, 0.75/0.25/0/0, 0.50/0.25/0.25/0 and 0.25/0.25/0.25/0.25 proportions prior to four cut intervals examined crude-protein-N and nitrate-N concentrations in grass herbage at each cut in three trials. Crude-protein-N concentration frequently increased to a greater degree and in a different pattern (based on cut) than yield as the rate of N application increased. This showed that crude-protein-N by itself cannot be used as a method for determining the N sufficiency status of grass. Both rate and distribution of fertilizer N strongly influenced plant nitrate-N concentration; the degree of change varied considerably among cuts and trials. Plant nitrate-N concentration in the control did not correspond to yield responsiveness to N application, making it a poor indicator of the plant's need for fertilizer applications. Residual effects of N applications on plant nitrate-N were noted into the last cut of the season from a single spring application. The effect of N rate and distribution, then, was a function of immediate and residual effects of the applications. There was some evidence that N present in the soil in nitrate-N form enhanced the potential for high nitrate-N in the plant. Plant nitrate-N concentrations accounted for up to 29% of the total N in the plant with concentrations greater than 4000 mg N kg−1 at the highest N application rates. Plant nitrate-N did not exceed 1000 mg N kg−1, a concentration considered safe for ruminants, when 75 kg N ha−1 or less ammonium nitrate was applied as a single application prior to a growth interval for all cuts. Since grass protein- and nitrate-N concentrations respond differently than yield to N applications, a specific combination of rate and distribution of fertilizer will not necessarily produce maximum herbage quantity and quality simultaneously. Key words: Crude-protein-N, plant nitrate-N, residual effect, split applications | [
"Horticulture",
"Plant Science",
"Agronomy and Crop Science"
] | |
Corrigendum | Studies in History and Philosophy of Science Part A | [
"History and Philosophy of Science",
"History"
] | |
Post-dam sediment dynamics and processes in the Colorado River estuary: Implications for habitat restoration | [
"Management, Monitoring, Policy and Law",
"Nature and Landscape Conservation",
"Environmental Engineering"
] | ||
La contribution des étrangers à la population de la France entre le 1er janvier 1946 et le 1er janvier 1980. Dossier statistique commenté | [
"Demography"
] | ||
A Case of Dermoid Cyst of the Pancreas | The Japanese Journal of Gastroenterological Surgery | [
"Gastroenterology",
"Surgery"
] | |
Variation of repetitive cortical spreading depression waves is related with relative refractory period: a computational study | Quantitative Biology | [
"Applied Mathematics",
"Computer Science Applications",
"Biochemistry, Genetics and Molecular Biology (miscellaneous)",
"Modeling and Simulation"
] | |
Spectral-domain optical coherence tomography for the non-invasive investigation of the pigment layers of Tang Dynasty tomb murals exhibited in museums | [
"Electrical and Electronic Engineering",
"Atomic and Molecular Physics, and Optics",
"Electronic, Optical and Magnetic Materials"
] | ||
Effects of Bovine Follicular Fluid and Passive Immunization against Gonadotropin-Releasing Hormone (GnRH) on Messenger Ribonucleic Acid for GnRH Receptor and Gonadotropin Subunits in Ovariectomized Ewes1 | [
"Cell Biology",
"Reproductive Medicine"
] | ||
Erosion, isostatic response, and the missing peneplains | [
"Earth-Surface Processes"
] | ||
Visual Localization across Seasons Using Sequence Matching Based on Multi-Feature Combination | [
"Electrical and Electronic Engineering",
"Biochemistry",
"Instrumentation",
"Atomic and Molecular Physics, and Optics",
"Analytical Chemistry"
] | ||
Editorial board | [
"Tourism, Leisure and Hospitality Management",
"Development"
] | ||
Post mortem sampling of the brain and other tissues in neurodegenerative disease | [
"Histology",
"Pathology and Forensic Medicine"
] | ||
Kingship, Religion, and Rituals in a Nigerian Community: A Phenomenological Study of Ondo Yoruba Festivals | [
"Religious Studies"
] | ||
Catalytic features of Rh and Ni supported catalysts in the steam reforming of glycerol to produce hydrogen | [
"Process Chemistry and Technology",
"Catalysis"
] | ||
Existence et construction des extensions galoisiennes et non-abéliennes de degré 8 d'un corps de caractéristique differente de 2. | [
"Applied Mathematics"
] | ||
The Activation Mechanism of Hsp26 does not Require Dissociation of the Oligomer | [
"Molecular Biology",
"Structural Biology"
] | ||
Hatchments in churches | [
"Library and Information Sciences",
"Literature and Literary Theory",
"Linguistics and Language",
"Language and Linguistics"
] | ||
“No die, no rest”? Coercive Discipline in Liberian Military Organisations | Discipline forms the backbone of all military organisations. While discipline is traditionally associated with draconian punishment, this association is increasingly only applied to non-Western contexts. African rebel movements and similar, weak organisations are represented especially often as lacking non-coercive means of instilling discipline. This article explores the utility of coercive discipline in one such context – the Second Liberian Civil War (1999–2003). I argue that Liberia's weak military organisations faced significant restrictions when it came to employing direct coercion. Executions, which are often equated with coercion in existing literature, threatened to rive the already frail organisations. Even other formal instruments of discipline, such as military hierarchies and rules and regulations, remained contested throughout the war. Consequently, more indirect means were adopted. Ultimately, the main users of coercion were not military organisations, but peers. This suggests that it is easier for strong organisations to coerce their members, and that the relationship between coercion and organisational strength may need to be reassessed. Furthermore, existing positive perceptions of camaraderie between brothers-in-arms requires re-evaluation. | [
"Political Science and International Relations",
"Sociology and Political Science",
"Development",
"Cultural Studies"
] | |
Exposure-Response Analysis for Beryllium Sensitization and Chronic Beryllium Disease Among Workers in a Beryllium Metal Machining Plant | Journal of Occupational and Environmental Hygiene | [
"Public Health, Environmental and Occupational Health"
] | |
Ausstellung von Meisterwerken mohammedanischer Kunst in München (Mai bis Oktober 1910). | [
"History",
"Cultural Studies"
] | ||
Indirect costs counteract the effects of pollinator-mediated phenotypic selection on corolla size in the Mediterranean shrub Halimium atriplicifolium | Journal of Plant Ecology | [
"Plant Science",
"Ecology",
"Ecology, Evolution, Behavior and Systematics"
] | |
Patients with functional dyspepsia have reduced fasting radial strain of the gastric antrum | [
"Radiology, Nuclear Medicine and Imaging"
] | ||
EDITORIAL | English | [
"Literature and Literary Theory"
] | |
Postepileptic Asystole | [
"Psychiatry and Mental Health"
] | ||
Shareholder Taxes in Acquisition Premiums: The Effect of Capital Gains Taxation | [
"Economics and Econometrics",
"Finance",
"Accounting"
] | ||
The Southern Hemisphere Westerlies in a Warming World: Propping Open the Door to the Deep Ocean | Abstract A coupled climate model with poleward-intensified westerly winds simulates significantly higher storage of heat and anthropogenic carbon dioxide by the Southern Ocean in the future when compared with the storage in a model with initially weaker, equatorward-biased westerlies. This difference results from the larger outcrop area of the dense waters around Antarctica and more vigorous divergence, which remains robust even as rising atmospheric greenhouse gas levels induce warming that reduces the density of surface waters in the Southern Ocean. These results imply that the impact of warming on the stratification of the global ocean may be reduced by the poleward intensification of the westerlies, allowing the ocean to remove additional heat and anthropogenic carbon dioxide from the atmosphere. | [
"Atmospheric Science"
] | |
Founder-Controlled Firms and R&D Investments: New Evidence From Canada | Our study investigates the R&D investment behavior of founder-controlled Canadian listed firms. We use De Massis et al.’s model of the sufficiency conditions of ability and willingness and adapt it to predict investments in R&D. As founder-controlled firms are heterogeneous in nature, we distinguish four categories: lone founder firms and family founder firms with and without excess voting rights. In line with our predictions, we find that only lone founder firms without excess voting rights have both the ability and the willingness to invest in R&D and so they invest more in R&D than their counterparts. | [
"Finance",
"Business, Management and Accounting (miscellaneous)"
] | |
Synthesis and Film-Forming Properties of Ethynylporphyrins | [
"Materials Chemistry"
] | ||
On Detecting and Classifying DGA Botnets and their Families | [
"Law"
] | ||
Peptide Hormone “Receptors”: Specific Binding of3H-FSH to Testis | [
"Endocrinology"
] | ||
Reductions in qEEG slowing over 1 year and after treatment with Cerebrolysin in patients with moderate–severe traumatic brain injury | [
"Biological Psychiatry",
"Psychiatry and Mental Health",
"Neurology (clinical)",
"Neurology"
] | ||
Nerve Growth Factor Delivery by Gene Transfer Induces Differential Outgrowth of Sensory, Motor, and Noradrenergic Neurites after Adult Spinal Cord Injury | Experimental Neurology | [
"Developmental Neuroscience",
"Neurology"
] | |
Selective Measurement Of Activated Contact Activation Factor XII In The Matrix Of Intravenous Immunoglobulin | [
"Immunology",
"Immunology and Allergy"
] | ||
Abstract PS13-32: Hormone- and HER2 receptor change in non-pCR breast cancer specimens after neoadjuvant treatment | Abstract Introduction: This study aimed at identification of breast cancer patients with a switched hormone- or HER2 receptor status after neoadjuvant chemotherapy. Therefore, patients without pathological complete response (pCR) were evaluated. The hormone and HER2 receptor status determined prior to neoadjuvant chemotherapy was compared with the corresponding receptor status determined in the surgical specimen after neoadjuvant chemotherapy. Methods: Clinicopathological data of 249 patients, who received neoadjuvant treatment between 2016 and 2019 at the LMU breast center, Munich were reviewed. Among those, 129 patients (52%) with non-pCR were identified. Of those, 11 patients had a residual positive lymph node only. pCR was defined as absence of invasive tumor in breast and lymph node (ypT0/is; ypN0). According to German clinical guidelines, specimens were labeled hormone receptor positive, if ≥1% of tumor nuclei were reported estrogen receptor positive or ≥10% of tumor nuclei were reported progesterone receptor positive. Tumors were labeled HER2-positive if immunohistochemistry showed strong complete circular membrane staining of >10% of invasive cells or if in-situ-hybridization showed HER2 positivity. Surgical specimens of patients with non-pCR were pathologically evaluated in order to 1) detect a receptor status switch compared to the analysis prior to neoadjuvant chemotherapy and 2) to see whether additional post neoadjuvant treatment options become available. Results: The following results apply exclusively to non-pCR cases. Median age at diagnosis was 51 years, 27 patients were younger than 40. One male patient is included.A total of 36 cases (28%) switched either hormone- or HER2-status, including two cases of a simultaneous switch. In 19 cases, the hormone receptor status switched. 3 patients switched from hormone receptor negative to positive, while 16 switched from hormone receptor positive to negative. A total of 17 cases showed a switch in HER2 receptor status. 6 patients switched from HER2-negative to HER2-positive, while 11 switched from HER2-positive to HER2-negative. Due to technical limitations, HER2 status was not evaluable in two cases, and hormone receptor status in one case. See table below. Conclusion: Our results illustrate, that a biomarker status switch after neoadjuvant treatment occurs in almost a third (28%) of cases. Reassessment of hormone- and HER2-receptor status subsequent to neoadjuvant treatment is still under discussion, with regard to post-neoadjuvant treatment. Nevertheless, it may have potential benefits for patients regarding individualization of treatment and potentially even patient outcome. At present, only gain of receptors should impact treatment concepts; in case of loss of receptors, treatment should not be changed as results in the residual tumor tissue may not reflect receptor status on disseminated tumor cells. Biomarker status in patients with non-pCRBiomarrker status in patients with non-pCRStatus at initial diagnosisStatus in surgical non-pCR specimenCases with switch in biomarker status after NACHR positive99 (77%)85 (66%)3HR negative30 (23%)43 (34%)16HR total12912819 (15%)HER2 positive35 (27%)28 (22%)6HER2 negative94 (73%)99 (78%)11HER2 total12912717 (13%)Cases with switch in biomarker status36 (28%) Citation Format: Moritz Dimpfl, Tom Degenhardt, Doris Mayr, Elisa Schmoeckel, Nadia Harbeck, Rachel Wuerstlein. Hormone- and HER2 receptor change in non-pCR breast cancer specimens after neoadjuvant treatment [abstract]. In: Proceedings of the 2020 San Antonio Breast Cancer Virtual Symposium; 2020 Dec 8-11; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2021;81(4 Suppl):Abstract nr PS13-32. | [
"Cancer Research",
"Oncology"
] | |
The Theoretical Calculations and Experimental Measurements of Acid Dissociation Constants and Thermodynamic Properties of Betanin in Aqueous Solutions at Different Temperatures | Journal of Solution Chemistry | [
"Physical and Theoretical Chemistry",
"Molecular Biology",
"Biochemistry",
"Biophysics"
] | |
Max Kaser, Das Römische Privatrecht, I. Abschnitt (Rechtsgeschichte des Altertums in Rahmen des Handbuchs der Altertumswissenschaft, X.3.3.1). Munich: C. H. Beck, 1955. Pp. XXVI + 651. DM 54. | Journal of Roman Studies | [
"Literature and Literary Theory",
"Archeology",
"Visual Arts and Performing Arts",
"History",
"Classics"
] | |
Synchronous primary double malignancy involving stomach and hepatic flexure of colon: A case report | [
"Oncology"
] | ||
Practical color measurement: A primer for the beginner, a reminder for the expert, by Anni Berger-Schunn, John Wiley & Sons, New York, 1994. 175 pp. $54.95 | [
"Human Factors and Ergonomics"
] | ||
Cloning and expression of the essential gene for guanylate kinase from yeast. | [
"Cell Biology",
"Molecular Biology",
"Biochemistry"
] | ||
On the permanent axes of motion for a heavy gyrostat near an immovable point | [
"Applied Mathematics",
"Mechanical Engineering",
"Mechanics of Materials",
"Modeling and Simulation"
] | ||
Observations on Myelination of Human Spinal Cord and Some Effects of Parturitional Transection | Journal of Neuropathology & Experimental Neurology | [
"Cellular and Molecular Neuroscience",
"Neurology (clinical)",
"Neurology",
"Pathology and Forensic Medicine"
] | |
Expression of nuclear and membrane progesterone receptors in the canine oviduct during the periovulatory period | Important reproductive events take place in the canine oviduct in the presence of increasing concentrations of progesterone (P4). To investigate the potential effects of P4 on the canine oviduct, the expression of nuclear (PR) and membrane (PGRMC1 and 2, mPRα, β and γ) P4 receptors was studied by quantitative RT-PCR and immunohistochemistry. Oviducts were collected from Beagle bitches after the onset of pro-oestrus and before the LH peak (Pre-LH), after the LH peak and before ovulation (Pre-ov) and on Days 1, 4 and 7 post-ovulation (n = 6 bitches/stage). PR mRNA concentrations decreased from Pre-LH to Day 7 in the ampulla and isthmus, whereas both PGRMC1 and 2 mRNA levels increased over the same period. The main change in mPR expression was an increase in mPRβ and γ mRNAs at Day 7 in the isthmus. Furthermore, PR proteins were expressed in the nuclei of luminal epithelial, stromal and muscular cells, whereas the expression of PGRMCs and mPRs was primarily cytoplasmic and localised in the luminal epithelium. The immunostaining for PR decreased at Day 4 in the stroma and muscle, whereas it remained strong in the epithelium from Pre-LH to Day 7. PGRMC1 staining was strong at Days 4 and 7 whereas PGRMC2 was highly expressed from Pre-ov to Day 7. The most intense immunostaining signals for all three mPRs were observed at Day 7. Our results strongly support the hypothesis that P4 is an important regulator of oviductal functions in the bitch through complementary classical and non-classical P4 pathways. | [
"Developmental Biology",
"Endocrinology",
"Genetics",
"Molecular Biology",
"Animal Science and Zoology",
"Reproductive Medicine",
"Biotechnology"
] | |
A simple phase-field model for interface tracking in three dimensions | [
"Computational Mathematics",
"Computational Theory and Mathematics",
"Modeling and Simulation"
] | ||
Facile synthesis of rare-earth pyrazolonates by the reaction of rare-earth metals with 1-phenyl-3-methyl-4-isobutyryl-5-pyrazolone. Crystal structures of [Ln(PMIP)3]2 (Ln=Y, Gd, Tb, Er, Tm) | Inorganica Chimica Acta | [
"Materials Chemistry",
"Inorganic Chemistry",
"Physical and Theoretical Chemistry"
] | |
Mão branca: a opinião pública e os grupos de extermínio no Brasil (1980-1985) | O objetivo é recompormos a prática utilizada pelo grupo de extermínio Mão Branca na cidade de Campina Grande, Paraíba, e com isso, questionarmos a classificação das suas vítimas, tanto na imprensa quanto na historiografia campinense. Para isso, utilizamos a teoria da história oral dos depoentes, denunciantes e testemunhas do Esquadrão da Morte em São Paulo, relacionada à transformação na cultura jornalística paulistana sobre os grupos de extermínio e a origem do jornalismo investigativo no Estadão. A partir daí, abordamos a proximidade da opinião pública carioca com o grupo de extermínio Mão Branca da Baixada Fluminense, a quem, o nome das vítimas e os locais aonde os corpos seriam encontrados eram informados e publicados em matérias de Capa do Última Hora. Tal método de imposição da ordem militar remanescente da ditadura e da “limpeza social” foi transportado do Rio de Janeiro para Campina Grande em 1979, quando o Grupo de Extermínio Mão Branca se formou, ainda sem a nomenclatura, mas baseado na extorsão e na tortura de marginais da Zona Leste da cidade. Isso, até a expulsão de um dos seus membros, Temporal, que ao retornar à corporação, como policial de oficio, por intermédio do segundo membro, o superintendente da polícia civil da Paraíba, Ciço Tomé, foi lotado como subordinado ao terceiro membro do grupo, o chefe de investigação da Primeira Delegacia Distrital, Zezé Basílio. Formava-se a versão campinense dos Mão Branca, que no ano de 1980, aparecia no jornal Diário da Borborema como o justiceiro, algoz de bandidos perigosos, e como supomos, a partir do paradigma indiciário de Ginzburg, influenciou o tratamento historiográfico campinense. A partir do momento que a identificação das vítimas passou a reconhecê-las como pobres marginalizados e/ou delinquentes, sem conjecturar que na realidade, a maioria das vítimas dos Mão Branca eram detentos do regime fechado ou semiaberto da Casa de Detenção de Campina Grande. A análise interpretativa do processo do único policial condenado pelos crimes do grupo, Zezé Basílio, revelou que: inspirados no grupo de extermínio carioca, os Mão Branca campinense, também telefonavam para o jornal, indicando a localização dos corpos. No entanto, parecido com o que ocorreu com o Esquadrão da Morte paulistano, a atitude da opinião pública campinense se transformou, a partir da denúncia dos parentes das vítimas, da sociedade civil e da igreja católica. Ainda assim, o que nunca foi dito é que as vítimas dos Mão Branca não eram pessoas perigosas, como exposto nos jornais, mas também, não eram apenas pobres marginalizados, como oferecido à historiografia, eram detentos da Casa de Detenção, que retirados de suas celas por Zezé Basílio e Ciço Tomé, com o pretexto de transferi-los de cela ou para a delegacia distrital, os levavam para a morte, registrada nas matérias de capa do Diário da Borborema, além de outras, que despistassem a prática. | [
"Marketing",
"Organizational Behavior and Human Resource Management",
"Strategy and Management",
"Drug Discovery",
"Pharmaceutical Science",
"Pharmacology"
] | |
CLINICAL OUTCOMES OF ABIRATERONE ACETATE FOR TREATMENT OF CASTRATION-RESISTANT PROSTATE CANCER: A RETROSPECTIVE ANALYSIS | The Japanese Journal of Urology | [
"Urology"
] | |
Fabrication and characterization of hydrophobic microarc oxidation/poly-lactic acid duplex coating on biodegradable Mg–Ca alloy for corrosion protection | [
"Surfaces, Coatings and Films",
"Condensed Matter Physics",
"Instrumentation"
] | ||
Sammelbericht pro 1888 | [
"Insect Science"
] | ||
Signaling pathways implicated in PGF2α effects on Fgf2+/+ and Fgf2−/− osteoblasts | Journal of Cellular Physiology | [
"Cell Biology",
"Clinical Biochemistry",
"Physiology"
] | |
Evaluation Model and Method of Margin in Electromagnetic Environmental Effects for Complex Systems | [
"Applied Mathematics",
"Electrical and Electronic Engineering"
] | ||
Exploring the disparity in tangible outcomes of internet use between persons with disabilities and persons without disabilities in South Korea | [
"Public Health, Environmental and Occupational Health"
] | ||
The context framing the changes in health-related quality of life and working competence before and after lung transplantation: one-year follow-up in Taiwan | [
"Transplantation",
"Surgery"
] | ||
Proteomic as an Exploratory Approach to Develop Vaccines Against Tick-Borne Diseases Using Lyme Borreliosis as a Test Case | Tick-borne diseases affecting humans and animals are on the rise worldwide. Vaccines constitute an effective control measure, but very few are available. We selected Lyme borreliosis, a bacterial infection transmitted by the hard tick Ixodes, to validate a new concept to identify vaccine candidates. This disease is the most common tick-borne disease in the Northern Hemisphere. Although attempts to develop a vaccine exist, none have been successfully marketed. In tick-borne diseases, the skin constitutes a very specific environment encountered by the pathogen during its co-inoculation with tick saliva. In a mouse model, we developed a proteomic approach to identify vaccine candidates in skin biopsies. We identified 30 bacterial proteins after syringe inoculation or tick inoculation of bacteria. Discovery proteomics using mass spectrometry might be used in various tick-borne diseases to identify pathogen proteins with early skin expression. It should help to better develop sub-unit vaccines based on a cocktail of several antigens, associated with effective adjuvant and delivery systems of antigens. In all vector-borne diseases, the skin deserves further investigation to better define its role in the elaboration of protective immunity against pathogens. | [
"Pharmacology (medical)",
"Infectious Diseases",
"Drug Discovery",
"Pharmacology",
"Immunology"
] | |
4816757 Reconfigurable integrated circuit for enhanced testing in a manufacturing environment | [
"Electrical and Electronic Engineering",
"Surfaces, Coatings and Films",
"Safety, Risk, Reliability and Quality",
"Condensed Matter Physics",
"Atomic and Molecular Physics, and Optics",
"Electronic, Optical and Magnetic Materials"
] | ||
Dwelling in Possibilities: Our Students' Spectacular Hunger for Life Makes Them Radically Vulnerable | Arts Education Policy Review | [
"Visual Arts and Performing Arts",
"Education"
] | |
Synthesis, aggregation behavior, and simvastatin solubilization by block polyethers with different structures | [
"Materials Chemistry",
"Colloid and Surface Chemistry",
"Polymers and Plastics",
"Physical and Theoretical Chemistry"
] | ||
Review of Dynamics of structures: Theory and applications to earthquake engineering by Anil S. Chopra | [
"Mechanical Engineering",
"Mechanics of Materials",
"Building and Construction",
"Civil and Structural Engineering"
] | ||
Messung des Scheitelwertes hoher Wechselspannungen, Teil I | [
"Electrical and Electronic Engineering",
"Instrumentation"
] | ||
Scientific Theory and Scientific Evidence: An Analysis of Lie-Detection | The Yale Law Journal | [
"Law"
] | |
Books received | [
"Education"
] | ||
The synthesis of inhibitors for processing proteinases and their action on the Kex2 proteinase of yeast | Peptidyl chloromethane and sulphonium salts containing multiple Arg and Lys residues were synthesized as potential inhibitors of prohormone and pro-protein processing proteinases. The potencies of these compounds were assayed by measuring the kinetics of inactivation of the yeast Kex2 proteinase, the prototype of a growing family of eukaryotic precursor processing proteinases. The most potent inhibitor, Pro-Nvl-Tyr-Lys-Arg-chloromethane, was based on cleavage sites in the natural Kex2 substrate pro-alpha-factor. This inhibitor exhibited a Ki of 3.7 nM and a second-order inactivation rate constant (k2/Ki) of 1.3 x 10(7) M-1.s-1 comparable with the value of kcat./Km obtained with Kex2 for the corresponding peptidyl methylcoumarinylamide substrate. The enzyme exhibited sensitivity to the other peptidyl chloromethanes over a range of concentrations, depending on peptide sequence and alpha-amino decanoylation, but was completely resistant to peptidyl sulphonium salts. Kinetics of inactivation by these new inhibitors of a set of ‘control’ proteinases, including members of both the trypsin and subtilisin families, underscored the apparent specificity of the compounds most active against Kex2 proteinase. | Biochemical Journal | [
"Cell Biology",
"Molecular Biology",
"Biochemistry"
] |
Advances in Deepwater-Pipeline Route Selection—A Gulf of Mexico Case Study | Summary The selection of pipeline routes and the location of the associated tie-in structures require detailed knowledge of the seabed conditions and shallow geology. The areas along the routes and the areas regionally around the routes must be accurately surveyed. This is especially important for the complex geology and seabed topography found in the deepwater Gulf of Mexico. The Mardi Gras project used an autonomous underwater vehicle (AUV) to provide high-quality survey data. These data allowed the project to make decisions with a high degree of confidence regarding pipeline routing, ultimately leading to successful installation of the Mardi Gras pipelines. | [
"Management, Monitoring, Policy and Law",
"Mechanical Engineering",
"Ocean Engineering"
] | |
AST and ALT correlate with oxidative stress in hpn patients | [
"Nutrition and Dietetics",
"Endocrinology, Diabetes and Metabolism"
] | ||
Pair production by γ-rays on electrons | [
"Physics and Astronomy (miscellaneous)",
"Engineering (miscellaneous)"
] | ||
The ORACLE I and II randomised trial results do not remove the need for prophylaxis against early onset Group B streptococcal disease | BJOG: An International Journal of Obstetrics and Gynaecology | [
"Obstetrics and Gynecology"
] | |
Estimation of dynamic discrete models from time aggregated data | [
"Applied Mathematics",
"Economics and Econometrics"
] | ||
Changes in nuclear composition following cyclic compression of the intervertebral disc in an in vivo rat-tail model | [
"Biomedical Engineering",
"Biophysics"
] | ||
Geographical origin and sexual-system evolution of the androdioecious plant Gynochthodes boninensis (Rubiaceae), endemic to the Bonin Islands, Japan | Molecular Phylogenetics and Evolution | [
"Genetics",
"Molecular Biology",
"Ecology, Evolution, Behavior and Systematics"
] | |
Blast Vibration Effects on Historical Buildings | Australian Journal of Structural Engineering | [
"Mechanical Engineering",
"Mechanics of Materials",
"Civil and Structural Engineering"
] | |
Highly fluorescent chiral N-S-doped carbon dots from cysteine: Affecting cellular energy metabolism | Free Radical Biology and Medicine | [
"Physiology (medical)",
"Biochemistry"
] | |
Xenotransplantation in Immunodeficient Mice to Evaluate New Therapeutic Strategies for Refractory Childhood Acute Lymphoblastic Leukemia | [
"Pediatrics, Perinatology and Child Health"
] | ||
WHY QUALITY INITIATIVES FAIL | The guru of the international quality movement explains what keeps going wrong with so many American efforts at total quality management. | Journal of Business Strategy | [
"Strategy and Management",
"Management Information Systems"
] |
B. F. Skinner's Skepticism About Choices and Future Consequences | [
"History and Philosophy of Science",
"Philosophy"
] | ||
Occurrence of triclosan in plasma of wild Atlantic bottlenose dolphins (Tursiops truncatus) and in their environment | [
"Health, Toxicology and Mutagenesis",
"Pollution",
"Toxicology"
] | ||
A study of selective and nonselective reactive ion etching of GaAs/AlGaAs materials | [
"Materials Chemistry",
"Electrical and Electronic Engineering",
"Condensed Matter Physics",
"Electronic, Optical and Magnetic Materials"
] | ||
A Phase Equation of Third-Order in Spatial Derivatives | [
"Physics and Astronomy (miscellaneous)"
] | ||
180: Do genetic and environmental influences on abnormal metabolic profile in pregnancy continue to second generation offspring? | [
"Obstetrics and Gynecology"
] | ||
Epidermal Growth Factor Regulation of Equine Glycoprotein Hormone α Subunit Expression in Trophoblast Cells1 | [
"Cell Biology",
"Reproductive Medicine"
] | ||
NICE alternatives | [
"Complementary and Alternative Medicine"
] |
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