Title stringlengths 0 905 | Abstract stringlengths 0 11.3k | Container_Title stringlengths 0 126 | Subject listlengths 1 13 |
|---|---|---|---|
Kinetics and reactivity of substituted anilines with 2-chloro-5-nitropyridine in dimethyl sulfoxide and dimethyl formamide | [
"Inorganic Chemistry",
"Organic Chemistry",
"Physical and Theoretical Chemistry",
"Biochemistry"
] | ||
Large momentum pion production in proton nucleus collisions and the idea of “fluctuons” in nuclei | [
"Nuclear and High Energy Physics"
] | ||
Minimisation of parameter estimation errors in dynamic PET: choice of scanning schedules | [
"Radiology, Nuclear Medicine and Imaging",
"Radiological and Ultrasound Technology"
] | ||
A new large amicable pair | [
"Computational Mathematics",
"Computational Theory and Mathematics",
"Modeling and Simulation"
] | ||
Thriving with Stone Age Minds: Evolutionary Psychology, Christian Faith, and the Quest for Human Flourishing, Justin L.Barrett and Pamela EbstyneKing, IVP, 2021 (ISBN 987‐0‐8308‐5293‐2), xvi + 192 pp., pb $20 | Reviews in Religion & Theology | [
"Industrial and Manufacturing Engineering",
"Environmental Engineering"
] | |
Mechanisms responsible for increasing immunoreactivity of apolipoprotein A-I with storage: the role of oxidation. | Abstract Atherogenesis has been linked to low concentrations of high-density lipoprotein and its principal carrier protein, apolipoprotein (apo) A-I, in serum. We measured apo A-I by enzyme-linked immunosorbent assay, using polyclonal antiserum raised against purified apo A-I and conjugated to peroxidase. During storage at 4 degrees C and above, the immunoreactivity of apo A-I increased so that measured values in stored serum were difficult to interpret. The immunoreactivity of serum apo A-I also increased substantially (up to 50-fold) during exposure to NaIO4. This increase was apo A-I concentration dependent, was linearly dependent on the concentration of NaIO4 up to 200 mmol/L at pH 7.4 and 25 degrees C, and was not ascribable to nonspecific binding of antibody-peroxidase conjugate to the reaction wells. Treatment with NaIO4 caused apo A-I immunoreactivity to increase to a peak or plateau, then gradually decline. In 100 mmol/L NaIO4 (pH 7.4, 25 degrees C), this plateau occurred 30-60 min after oxidation commenced. When frozen serum and stored nonfrozen serum were both oxidized with NaIO4 under the same conditions, the apo A-I from the frozen serum had a significantly (P = 0.0004) greater increase in immunoreactivity. Sera from different patients with different apo A-I concentrations did not have proportionately increased immunoreactivity after treatment with NaIO4. Our findings suggest that the increase in apo A-I immunoreactivity on storage at 4 degrees C or higher involves atmospheric oxidation, and they raise the possibility of in vivo oxidized and nonoxidized forms of apo A-I. | Clinical Chemistry | [
"Biochemistry (medical)",
"Clinical Biochemistry"
] |
An Ombudsman for Advances | Advances in Skin & Wound Care | [
"Advanced and Specialized Nursing",
"Dermatology"
] | |
Two Outstanding Explosives Based on 1,2-Dinitroguanidine: Ammonium- dinitroguanidine and 1,7-Diamino-1,7-dinitrimino-2,4,6-trinitro-2,4,6-triazaheptane | [
"Inorganic Chemistry"
] | ||
GU/Ob/Gyn | [
"Radiology, Nuclear Medicine and Imaging"
] | ||
WESTMINSTER AND BRUSSELS THE RELATIONSHIP OF PARLIAMENT TO THE eec | [
"Public Administration",
"Sociology and Political Science"
] | ||
58-OR | [
"Immunology",
"Immunology and Allergy"
] | ||
Correspondence | [
"Anesthesiology and Pain Medicine",
"Neurology (clinical)"
] | ||
Polythiophene-coated Fe3O4 superparamagnetic nanocomposite: Synthesis and application as a new sorbent for solid-phase extraction | [
"Spectroscopy",
"Environmental Chemistry",
"Biochemistry",
"Analytical Chemistry"
] | ||
A new device for density gradient fractionation | [
"Cell Biology",
"Molecular Biology",
"Biochemistry",
"Biophysics"
] | ||
Small molecules as friends and foes of the immune system | Every organism is in contact with numerous small molecules ( | [
"Drug Discovery",
"Pharmacology",
"Molecular Medicine"
] | |
Editorial Board | [
"Gerontology"
] | ||
Editorial | [
"Cell Biology",
"Histology",
"Pathology and Forensic Medicine"
] | ||
Chest Radiograph Findings in Asymptomatic and Minimally Symptomatic Quarantined Patients in Codogno, Italy during COVID-19 Pandemic | Radiology | [
"Radiology, Nuclear Medicine and Imaging"
] | |
Nitrogen fertilization increases rice rhizodeposition and its stabilization in soil aggregates and the humus fraction` | [
"Plant Science",
"Soil Science"
] | ||
GEE-based Bell model for longitudinal count outcomes | [
"Statistics and Probability"
] | ||
Editorial | [
"Small Animals"
] | ||
A ORIGEM E OS FUNDAMENTOS DA SEQUÊNCIA FEDATHI | Este artigo tem a finalidade de apresentar, por meio de uma análise histórico-conceitual, a origem e os fundamentos da Sequência Fedathi, método de ensino que conduz a ação do professor em sala de aula no processo de ensino para a aprendizagem do aluno, desenvolvido pelo professor Hermínio Borges Neto no início da década de 1970. O texto inicia-se com um breve relato histórico e, em seguida, mostra as concepções filosóficas do campo da matemática que influenciaram seu desenvolvimento e sistematização, perpassando pelos fundamentos e princípios que embasam a concepção fedathiana de ensino, em seguida, traz uma ideia de seus níveis: preparação, vivência e análise. Este trabalho foi realizado a partir de uma análise bibliográfica assim como de observações das vivências cotidianas do Laboratório de Pesquisa Multimeios da Faculdade de Educação (Faced) da Universidade Federal do Ceará (UFC) e nas pesquisas desenvolvidas ao longo dos anos sobre a proposta metodológica aqui apresentada assim como em obras do campo da Educação Matemática. A partir de uma fundamentação lógico-dedutiva-construtiva, a proposta de Borges Neto (2016) desenvolveu-se durante três décadas e, atualmente, caminha para uma consolidação por meio das experiências em sala de aula vividas por seus pesquisadores da matemática e também dos que atuam além das ‘ciências duras’. | [
"Marketing",
"Organizational Behavior and Human Resource Management",
"Strategy and Management",
"Drug Discovery",
"Pharmaceutical Science",
"Pharmacology"
] | |
A novel practical truss-based approach for evaluation the non-linear behavior of steel plate shear walls | [
"Safety, Risk, Reliability and Quality",
"Building and Construction",
"Architecture",
"Civil and Structural Engineering"
] | ||
Cecil Bendall (ed.): Çikshāsamuccaya: a compendium of Buddhistic teaching complied by Çāntideva chiefly from earlier Mahāyāna-sūtras. (Indo-Iranian Reprints, I.) [vii] vii, xlvii, 419 pp. front. 's-Gravenhage: Mounton & Co., 1957(Distributed in G.B. by International University Booksellers. £3 2s | [
"History",
"Cultural Studies"
] | ||
Quantum chemistry study on the open end of single-walled carbon nanotubes | [
"Physical and Theoretical Chemistry"
] | ||
Application of impedance boundary conditions in finite element analysis of linear motors | [
"Electrical and Electronic Engineering",
"Electronic, Optical and Magnetic Materials"
] | ||
A Pedological Catenal Characterization along Steeply Sloped and Perhumid Regions: The Case Study of Piedemonte Llanero, Colombia | Owing to data scarcity, the soil properties of the Colombian “Piedemonte Llanero” are poorly quantified. To provide basic information about how pedogenic properties along a steeply sloped and perhumid landscape are related to its use (which can help lead toward better management and establishment of a sustainable crop production system), this work addresses the characterization of the morphogenetic and chemical features of selected Piedemonte Llanero soils. Research was conducted in a sequence of soils composed of four profiles located in a transect of 200–1800 m of altitude. After macromorphologically identifying, describing, and analyzing soils based on these data, soil weathering and general fertility were interpreted. Ultisols, Inceptisols, Entisols and Oxisols were fundamentally identified according to Soil Taxonomy; that is, Lixisols, Cambisols, Umbrisols, and Ferralsols, according to IUSS Working Group WRB (2015). The dominant effect of humidity attributes in soil formation, with slope and slope gradients, was the major controlling factor for the contrasting soil genesis and properties along the watershed sequence. The acid character, low cation exchange capacity, and degree of saturation stood out, and, including the inherent increase in Al3+ of change, were the most outstanding characters. The data obtained by this study present a substantial basis for good land use planning and will facilitate technology to be transferred from one area to another with a similar environmental picture. | Agriculture | [
"Plant Science",
"Agronomy and Crop Science",
"Food Science"
] |
Rabdomiosarcoma y tumor del saco de Yolk testicular | ANTECEDENTES: las neoplasias testiculares tienen características morfológicas y manifestaciones clínicas diversas, representan de 1 a 2% de todos los cánceres malignos del hombre y hasta 10% de todas las enfermedades malignas del sistema genitourinario masculino.OBJETIVO: reportar la incidencia, diagnóstico, tratamiento y pronóstico del rabdomiosarcoma testicular y tumor del saco vitelino.CASO CLÍNICO: paciente masculino de 43 años de edad, con padecimiento de ocho meses de evolución caracterizado por aumento de volumen testicular izquierdo, doloroso, de intensidad moderada, irradiado al miembro inferior ipsilateral, con cuadros de remisión y exacerbación, acompañados de dificultad para la ventilación. Se le realizó orquiectomía radical izquierda. El informe histopatológico fue de tumor mixto de células germinales compuesto por tumor de saco vitelino sarcomatoide (50%) y rabdomiosarcoma (30%).CONCLUSIONES: los rabdomiosarcomas intratesticulares son agresivos e infrecuentes. Es común que al momento del diagnóstico los rabdomiosarcomas se manifiesten con afectación ganglionar o metástasis. El estadio clínico, el tipo histológico y el apego al tratamiento influyen en la evolución natural del cáncer.PALABRAS CLAVE: rabdomiosarcoma, saco de Yolk, orquiectomía, testicular. | Revista Mexicana de Urología | [
"Urology"
] |
Electronic structure of BaSnO3investigated by high-energy-resolution electron energy-loss spectroscopy andab initiocalculations | Journal of Vacuum Science & Technology A: Vacuum, Surfaces, and Films | [
"Surfaces, Coatings and Films",
"Surfaces and Interfaces",
"Condensed Matter Physics"
] | |
Technical Notes: Electronic Versus Fluid Multiplexing in Recording Tensiometer Systems | [
"Agricultural and Biological Sciences (miscellaneous)"
] | ||
Protected nanoaperture based on multi-excitation of the localized surface plasmon between a ridge nanoaperture and metal nanoparticle | [
"Physics and Astronomy (miscellaneous)"
] | ||
Boris Mikhailovich Mirkin (to the 75th anniversary of his birthday) | Vegetation of Russia | [
"Plant Science",
"Ecology, Evolution, Behavior and Systematics"
] | |
Production and characterization of bamboo-based activated carbon through single-step H3PO4 activation for CO2 capture | [
"Health, Toxicology and Mutagenesis",
"Pollution",
"Environmental Chemistry"
] | ||
Investigations of the relation between fabric mechanical properties and behaviour | In transforming fabrics into garment it is necessary to know, besides the manner of processing, the behaviour of the fabric in particular manufacturing processes. It is necessary to define why and how fabrics behave in a particular way when exposed to various strains. The answers to these questions are obtained by investigating fabric mechanics, as non‐linear mechanical fabric properties at lower strains, which is the case in transforming fabrics into garments. The area to be investigated is quite wide and the investigations presented here deal only with the most important elastic strains occurring in processing fabrics into garments, such as tensile, pressure, shear and bending, as each individual type of strain bears specific importance in studying fabric behaviour, as well as in garment quality control. Strains impacting the fabric, i.e. the reaction of the fabric to these strains, are presented through the parameters of mechanical properties. A relation is also explained between characteristic histeresis curves and fabric behaviour in real garment manufacturing processes, obtained through recording fabric behaviour in particular garment manufacturing processes. Results obtained through the investigations of mechanical properties of the fabrics analysed and their behaviour in garment manufacturing processes helped to determine the so‐called critical, or border values for particular parameters of mechanical properties. | [
"Polymers and Plastics",
"Materials Science (miscellaneous)",
"Business, Management and Accounting (miscellaneous)"
] | |
An Offbeat Wheezer | [
"Pediatrics, Perinatology and Child Health"
] | ||
Effects of Early Life Stress on the Developing Basolateral Amygdala-Prefrontal Cortex Circuit: The Emerging Role of Local Inhibition and Perineuronal Nets | The links between early life stress (ELS) and the emergence of psychopathology such as increased anxiety and depression are now well established, although the specific neurobiological and developmental mechanisms that translate ELS into poor health outcomes are still unclear. The consequences of ELS are complex because they depend on the form and severity of early stress, duration, and age of exposure as well as co-occurrence with other forms of physical or psychological trauma. The long term effects of ELS on the corticolimbic circuit underlying emotional and social behavior are particularly salient because ELS occurs during critical developmental periods in the establishment of this circuit, its local balance of inhibition:excitation and its connections with other neuronal pathways. Using examples drawn from the human and rodent literature, we review some of the consequences of ELS on the development of the corticolimbic circuit and how it might impact fear regulation in a sex- and hemispheric-dependent manner in both humans and rodents. We explore the effects of ELS on local inhibitory neurons and the formation of perineuronal nets (PNNs) that terminate critical periods of plasticity and promote the formation of stable local networks. Overall, the bulk of ELS studies report transient and/or long lasting alterations in both glutamatergic circuits and local inhibitory interneurons (INs) and their associated PNNs. Since the activity of INs plays a key role in the maturation of cortical regions and the formation of local field potentials, alterations in these INs triggered by ELS might critically participate in the development of psychiatric disorders in adulthood, including impaired fear extinction and anxiety behavior. | [
"Behavioral Neuroscience",
"Biological Psychiatry",
"Psychiatry and Mental Health",
"Neurology",
"Neuropsychology and Physiological Psychology"
] | |
Vorbereitung zur Facharztprüfung HNO | [
"Otorhinolaryngology"
] | ||
Mentored Reviews | [
"Urology",
"Obstetrics and Gynecology",
"Surgery"
] | ||
Abstracts and Discussions, Atlantic City Meeting, 1936 | [
"Atmospheric Science"
] | ||
mmCSM-AB: guiding rational antibody engineering through multiple point mutations | Abstract While antibodies are becoming an increasingly important therapeutic class, especially in personalized medicine, their development and optimization has been largely through experimental exploration. While there have been many efforts to develop computational tools to guide rational antibody engineering, most approaches are of limited accuracy when applied to antibody design, and have largely been limited to analysing a single point mutation at a time. To overcome this gap, we have curated a dataset of 242 experimentally determined changes in binding affinity upon multiple point mutations in antibody-target complexes (89 increasing and 153 decreasing binding affinity). Here, we have shown that by using our graph-based signatures and atomic interaction information, we can accurately analyse the consequence of multi-point mutations on antigen binding affinity. Our approach outperformed other available tools across cross-validation and two independent blind tests, achieving Pearson's correlations of up to 0.95. We have implemented our new approach, mmCSM-AB, as a web-server that can help guide the process of affinity maturation in antibody design. mmCSM-AB is freely available at http://biosig.unimelb.edu.au/mmcsm_ab/. | [
"Genetics"
] | |
Jet from the enigmatic high-latitude star BP Psc and evolutionary status of its driving source | ABSTRACT BP Psc is an active late-type (sp:G9) star with unclear evolutionary status lying at high-galactic latitude b = −57°. It is also the source of the well collimated bipolar jet. We present results of the proper motion and radial velocity study of BP Psc outflow based on the archival Hα imaging with the GMOS camera at 8.1-m Gemini-North telescope as well as recent imaging and long-slit spectroscopy with the SCORPIO multimode focal reducer at 6-m BTA telescope of SAO RAS. The 3D kinematics of the jet revealed the full spatial velocity up to ∼140 km s−1 and allows us to estimate the distance to BP Psc system as D = 135 ± 40 pc. This distance leads to an estimation of the central source luminosity L* ≈ 1.2 L⊙, indicating that it is the ≈1.3M⊙ T Tauri star with an age t ≲ 7 Myrs. We measured the electron density of order Ne ∼ 102 cm−3 and mean ionization fraction f ≈ 0.04 within the jet knots and estimated upper limit of the mass-loss rate in NE lobe as $\dot{M | [
"Space and Planetary Science",
"Astronomy and Astrophysics"
] | |
THE PRODUCTION OF FATTY LIVERS IN RATS ON THREONINE- AND LYSINE-DEFICIENT DIETS | [
"Cell Biology",
"Molecular Biology",
"Biochemistry"
] | ||
Individual Differences in Interest and Narrative Writing | [
"Developmental and Educational Psychology",
"Education"
] | ||
Amalgams as Alternative Bonding Materials | Amalgams, which are mechanically alloyed mixes of a liquid metal with a powder, offer advantages in situations where large devices are to be bonded to materials with significant coefficient of expansion differences or where extremely temperature‐sensitive devices are to be bonded. This is because these materials will set or harden at or near room temperature to yield hard metallic bonds with melting points from 280°C up to ∼600°C depending upon the systems used. In this paper the results of a survey study of three binary systems of gallium with copper, nickel and silver are described. Wetting characteristics, bond strengths with and without metallisation, bulk properties including electrical and thermal properties and thermal cycle performance of joints are described. The feasibility of using these materials for bonding metallised and unmetallised surfaces of a variety of ceramics and semiconductors is clearly demonstrated. | Soldering & Surface Mount Technology | [
"Electrical and Electronic Engineering",
"Condensed Matter Physics"
] |
Österreichischer Sachstandsbericht Klimawandel 2014 | Von rund 240 Forschenden erstellt, repräsentiert derÖsterreichische Sachstandsbericht Klimawandel 2014 (AAR14) die Konsensposition der österreichischen Klimaforschungs-Community zu Klimawandel, seinen Folgen und Maßnahmen in Österreich. Er bietet eine politikrelevante Einschätzung des Kenntnisstands, ohne politische Vorgaben zu liefern. | [
"Economics, Econometrics and Finance (miscellaneous)",
"Environmental Science (miscellaneous)"
] | |
Pseudoexfoliation syndrome: pathological manifestations of relevance to intraocular surgery | [
"Ophthalmology"
] | ||
The experience of administration of the preparation tonsilgon n in treatment of chronic tonsillitis in sickly children | The analysis of clinical efficacy of Tonsilgon N was performed on the basis of clinical observations of 35 sickly children with chronic tonsillitis (single-agent trial). Following the analysis the authors established the advisability of Tonsilgon N administration in treatment of the compensated form of chronic tonsillitis in sickly and chronically ailing children. The reduced frequency of acute respiratory viral diseases and the decreased risk of its transition into the decompensated form of chronic tonsillitis have also been recorded. | [
"Geology",
"Ocean Engineering",
"Water Science and Technology"
] | |
BOOK REVIEWS | [
"Public Health, Environmental and Occupational Health"
] | ||
On the Relative Efficiency of Different Methods of Determining Longitudes on Jupiter | [
"Space and Planetary Science",
"Astronomy and Astrophysics"
] | ||
The spin-orbit splitting in the Si bandstructure measured by means of spin-resolved photoemission | [
"Materials Chemistry",
"Condensed Matter Physics"
] | ||
Bianchi Type-I Dust-Filled Accelerating Brans–Dicke Cosmology | [
"Astronomy and Astrophysics"
] | ||
Mixed oligonucleotides for random mutagenesis: best way of making them | [
"Organic Chemistry",
"Physical and Theoretical Chemistry",
"Biochemistry"
] | ||
Magnificat and Nunc Dimittis, from the First Service | Notes | [
"Library and Information Sciences",
"Music"
] | |
Anillin promotes astral microtubule-directed cortical myosin polarization | Assembly of a cytokinetic contractile ring is a form of cell polarization in which the equatorial cell cortex becomes differentiated from the polar regions. Microtubules direct cytokinetic polarization via the central spindle and astral microtubules. The mechanism of central spindle–directed furrow formation is reasonably well understood, but the aster-directed pathway is not. In aster-directed furrowing, cytoskeletal factors accumulate to high levels at sites distal to the asters and at reduced levels at cortical sites near the asters. In this paper, we demonstrate that the cytoskeletal organizing protein anillin (ANI-1) promotes the formation of an aster-directed furrow in Caenorhabditis elegans embryos. Microtubule-directed nonmuscle myosin II polarization is aberrant in embryos depleted of ANI-1. In contrast, microtubule-directed polarized ANI-1 localization is largely unaffected by myosin II depletion. Consistent with a role in the induction of cortical asymmetry, ANI-1 also contributes to the polarization of arrested oocytes. Anillin has an evolutionarily conserved capacity to associate with microtubules, possibly providing an inhibitory mechanism to promote polarization of the cell cortex. | [
"Cell Biology",
"Molecular Biology"
] | |
Using root cause analysis to promote critical thinking in final year Bachelor of Midwifery students | [
"Education"
] | ||
Female Reproductive Cycle and Obsessive-Compulsive Disorder | The Journal of Clinical Psychiatry | [
"Psychiatry and Mental Health"
] | |
Conrad Celtes and Kunz von der Rosen: Two Problems in Portrait Identification | [
"History",
"Visual Arts and Performing Arts"
] | ||
Anorectal Infection: Abscess-Fistula | [
"Gastroenterology",
"Surgery"
] | ||
Synchronization in the cell cycle by inhibitors of DNA replication induces histone H2AX phosphorylation: an indication of DNA damage | [
"Cell Biology"
] | ||
Plant Direct | [
"Plant Science",
"Biochemistry, Genetics and Molecular Biology (miscellaneous)",
"Ecology",
"Ecology, Evolution, Behavior and Systematics"
] | ||
Athletes and Others in Brutal Heat or Cold “And There Are Storms We Cannot Weather...” | [
"Public Health, Environmental and Occupational Health",
"Orthopedics and Sports Medicine"
] | ||
Differential induction of c-fos and c-myc during ischemic preconditioing in swine | Journal of Molecular and Cellular Cardiology | [
"Cardiology and Cardiovascular Medicine",
"Molecular Biology"
] | |
The utility and accuracy of computed tomography in the diagnosis of occipitocervical dissociation | [
"Neurology (clinical)",
"Surgery",
"Orthopedics and Sports Medicine"
] | ||
Reply | The Journal of Pediatrics | [
"Pediatrics, Perinatology and Child Health"
] | |
Physical Awareness a Key to Improving Adolescent Male Health: A Grounded Theory Study of the Perception of Testicular Self-examination in Male Student Athletes | [
"Advanced and Specialized Nursing"
] | ||
Multiple Sclerosis and Antecedent Infections | [
"Epidemiology"
] | ||
Reevaluation of Edrophonium Chloride Test in Childhood Myasthenia Gravis | Pediatrics International | [
"Pediatrics, Perinatology and Child Health"
] | |
Electrochemical behaviour of zirconium metal and its oxide film in LiOH and HF solutions | Journal of Applied Electrochemistry | [
"Materials Chemistry",
"Electrochemistry"
] | |
Book review | Transportation Research Part A: Policy and Practice | [
"Management Science and Operations Research",
"Transportation",
"Civil and Structural Engineering"
] | |
Pill burden and out-of-pocket medication costs of a contemporary heart failure with reduced ejection fraction cohort | Abstract Introduction Modern pharmacological treatment of heart failure with reduced ejection fraction (HFrEF) dramatically improves its prognosis. However, the increasingly complexity and associated costs might threat their effective uptake in clinical practice. We aimed to study the pill burden and out-of-pocket costs of cardiovascular drug therapy of a contemporary cohort of HFrEF patients. Methods We performed a retrospective, cross-sectional, single-center study on a convenience sample of 100 consecutive HFrEF patients assessed at our HF outpatient clinic (January-June 2020). The pill burden was assessed by the number of prescribed different cardiovascular drugs and pills per day. The out-of-pocket (OOP) costs were defined using the total patients co-payment of cardiovascular medications per month of treatment, taken in account the exemptions provided by the Portuguese National Health System (NHS). The included drug classes were antiplatelets, anticoagulants, statins, HF drugs (Beta-blockers [BB], angiotensin-converting enzyme inhibitors [ACEi]/ angiotensin receptor blockers [ARBs]/ angiotensin receptor-neprilysin inhibition [ARNI], mineralocorticoid antagonists [MRA], sodium glucose cotransport inhibitors [iSGLT2], digoxin, loop diuretic) and antiarrhythmics. Results The mean age was 62±12 years and only 24% were female. The etiology of HF was ischemic in 42% of the patients, 86% were in NYHA II class and 5% in NYHA III-IV. The mean LVEF was 34±5% and the median NT-proBNP was 482 pg/mL [172–1120]. 92% of patients were on BB, 67% on ACEI/ARBs, 25% on ARNI, 81% on MRA and 30% on iSGLT2. The use of implantable cardioverter-defibrillators was 38% and 20% of patients were resynchronized. The number of cardiovascular (CV) drugs per day was 5.4±1.6 per patient and the number of CV pills per day was 6.6±2. Most patients (65%) had low income and had the maximal exemption on medication costs provided by NHS. Overall, the mean OOP costs was €16.1 per month of treatment and the mean OOP costs for patients exempted and not exempted was €12.9 and €22.3, respectively. The mean OOP costs of evidence-based HF-modifying drugs (BB, ACEI/ARBs, ARNI, MRA, iSGLT2) was €10.1 and the mean OOP costs of evidence-based HF-modifying drugs for patients exempted and not exempted were €7.9 and €14.2, respectively. However, for patients on ARNI the mean OOP costs was almost 3 times higher (€33.6). Conclusions In this optimally treated contemporary cohort of HFrEF, the pill burden due to cardiovascular therapy only is high (7 pills/day). With the exception of patients on ARNI, the overall OOP costs of HF-modifying prognostic drugs are low. Funding Acknowledgement Type of funding sources: None. | [
"Cardiology and Cardiovascular Medicine"
] | |
Evaluation of oil sludge as an alternative fuel in the production of Portland cement clinker | Construction and Building Materials | [
"Building and Construction",
"Civil and Structural Engineering"
] | |
Noninferiority of three monthsversussix months of oxaliplatin‐based adjuvant chemotherapy for resected colon cancer. How shouldIDEAfindings affect clinical practice? | [
"Cancer Research",
"Oncology"
] | ||
A G4-DNA/B-DNA junction at codon 12 of c-Ha-ras is actively and asymmetrically methylated by DNA (cytosine-5)methyltransferase | [
"Cell Biology",
"Molecular Biology",
"Biochemistry",
"Biophysics"
] | ||
Characterization of microwave processed aluminium powder | [
"Materials Chemistry",
"Surfaces, Coatings and Films",
"Process Chemistry and Technology",
"Ceramics and Composites",
"Electronic, Optical and Magnetic Materials"
] | ||
Sustained Efficacy and Safety Of a Pre-coseasonal 300IR 5-grass Pollen SLIT Tablet Over 3 Pollen Seasons In Adult SAR | Journal of Allergy and Clinical Immunology | [
"Immunology",
"Immunology and Allergy"
] | |
Free Vibration Analysis of Symmetrically Laminated Fully Clamped Skew Plates Using Extended Kantorovich Method | In this paper, free vibration analysis of thin symmetrically laminated skew plates with fully clamped edges is investigated. The governing differential equation for skew plate which is a fourth order partial differential equation (PDE) is obtained by transforming the differential equation in Cartesian coordinates into skew coordinates. Based on the multi-term extended Kantorovich method (MTEKM) an efficient and accurate approximate closed-form solution is presented for the governing PDE. Application of the MTEKM reduces the governing PDE to a dual set of ordinary differential equations. These sets of equations are then solved with infinite power series solution, in an iterative manner until convergence was achieved. Results of this study show the fast rate of convergence of the MTEKM. Usually two or three iterations are enough to obtain reasonably accurate results. The frequency parameters of laminated composite plates are obtained for different skew angles and lay-up configuration for different composites laminates skew plates. Comparisons have been made with the available results in the literature which show the accuracy and efficiency of the method. | Key Engineering Materials | [
"Mechanical Engineering",
"Mechanics of Materials"
] |
Community dominance by a canopy species controls the relationship between macroalgal production and species richness | [
"Aquatic Science",
"Oceanography"
] | ||
Gender, age and flexible working in later life | In many countries economic and social concerns associated with ageing populations have focused attention onto flexible forms of working as key to encouraging people to work longer and delay retirement. This article argues that there has been a remarkable lack of attention paid to the role of gender in extending working lives and contends that this gap has arisen because of two, inter-related, oversights: little consideration of relationships between gender and flexible working beyond the child-caring phase of life; and the prevailing tendency to think of end of working life and retirement as gender-neutral or following a typical male trajectory. The findings of a qualitative study of people aged 50+ in the UK challenge some of the key assumptions underpinning the utility of flexible work in extending working lives, and provide insight into the ways in which working in later life is constructed and enacted differently for men and women. | Work, Employment and Society | [
"Organizational Behavior and Human Resource Management",
"Economics and Econometrics",
"Sociology and Political Science",
"Accounting"
] |
A coordinated health communication campaign addressing casino and sports gambling among undergraduate students | Research has outlined many negative effects of disordered gambling. While gambling disorder exists among all US sociodemographic groups, college students are particularly vulnerable. This study describes a health communication approach commonly studied in the intervention of college behaviors such as risky alcohol/substance use and sexual activity. Specifically, two health communication messages targeting casino and sports betting disordered gambling were distributed at a Midwestern US public research university, and central intercept techniques were utilized to collect quantitative and qualitative data assessing student reception. Results revealed females preferred the casino message more than males (U = 4696.50, p | [
"Psychiatry and Mental Health",
"Clinical Psychology"
] | |
Mimicry in Trypanosoma cruzi: fantasy and reality | Current Opinion in Immunology | [
"Immunology",
"Immunology and Allergy"
] | |
Utilization of methanol and acetone as mutual solvents to reduce interfacial tension (IFT) in enhanced oil recovery process by carbonated smart water injection | [
"Materials Chemistry",
"Physical and Theoretical Chemistry",
"Spectroscopy",
"Condensed Matter Physics",
"Atomic and Molecular Physics, and Optics",
"Electronic, Optical and Magnetic Materials"
] | ||
TRAUMATISMES CRANIO-CÉRÉBREAUX. MÉCANISME ET ÉTIOLOGIE. FRACTURES DE LA VOUTE ET DE LA BASE. SYMPTOMES LOCALISATEURS | The Journal of Nervous and Mental Disease | [
"Psychiatry and Mental Health"
] | |
A RANDOMIZED CONTROLLED TRIAL OF THE EFFECT OF ALCOHOL CONSUMPTION ON BLOOD PRESSURE | [
"Physiology (medical)",
"Pharmacology",
"Physiology"
] | ||
Pathogenicity of Vibrio harveyi to salmonids | [
"Veterinary (miscellaneous)",
"Aquatic Science"
] | ||
Promotion effect of support calcination on ethanol production from CO hydrogenation over Rh/Fe/Al2O3 catalysts | [
"Process Chemistry and Technology",
"Catalysis"
] | ||
Adolescent Students’ Knowledge of Depression and Appropriate Help-seeking in Nigeria | [
"Community and Home Care"
] | ||
Neurofeedback for opioid dependent patients in an outpatient setting: a pilot feasibility study | Abstract Background Neurofeedback (NF) has been described as “probably efficacious” when used in conjunction with other interventions for substance use disorders, including the recent studies in the population of individuals with opioid use disorder. Despite these promising outcomes, the seriousness of the opioid epidemic, and the high rate of relapse even with the most effective medication-assisted maintenance treatments NF continues to be an under-researched treatment modality. This article explores factors that affected the feasibility of adding Alpha/Theta Neurofeedback to treatment as usual for opioid dependence in an outpatient urban treatment center. The study strived to replicate previous research completed in Iran that found benefits of NF for opioid dependence. Methods Out of approximately two dozen patients eligible for Alpha/Theta NF, about 60% (n = 15) agreed to participate; however, only 2 participants completed treatment. The rates of enrollment in response to active treatment were monitored. Results The 4 factors affecting feasibility were: (1) the time commitment required of participants and providers, (2) ineffectiveness of standard incentives to promote participation, (3) delayed effects of training, and (4) the challenges of researching treatment options not reimbursed by the insurance companies. Conclusions The findings indicate that a large-scale study examining the use of NF for the treatment of opioid use disorder in the United States will likely be difficult to accomplish without modification to the traditional randomized control study approach and suggests challenges to the implementation of this treatment in an outpatient setting. A single-case methodology is proposed as a viable alternative. | [
"Psychiatry and Mental Health",
"Health Policy"
] | |
Sustainability in manufacturing processes: practices performed in metal forming, casting, heat treatment, welding and electrostatic painting | International Journal of Sustainable Development & World Ecology | [
"Management, Monitoring, Policy and Law",
"Geography, Planning and Development"
] | |
Influence of bagasse ash with different fineness on alkali-silica reactivity of mortar | This research aimed to study the effect of finenesses of bagasse ash (BGA) on the alkali-silica reaction of mortar. The BGA sample was ground to have particles retained on a sieve No. 325 of 33±1% and 5±1% by weight. Ground BGA samples were used separately to replace ordinary Portland cement (OPC) at rates of 10, 20, 30 and 40% by weight of binder to cast mortars. The compressive strengths and the alkali-silica reaction (ASR) of mortars were investigated. The results showed that a large particle size of BGA is not suitable for use in lowering ASR because it results in a low compressive strength and high expansion due to ASR. The mortars containing BGA with higher fineness exhibited higher compressive strength and lower expansion due to ASR than the mortars containing BGA with lower fineness. The results also suggested that the ground BGA retained on a sieve No. 325 of less than 5% by weight is suitable to be used as a good pozzolan which provides high compressive strength and reduces the expansion of mortar due to ASR even though it contains high LOI. The obtained results also encourage the utilization of ground BGA effectively which leads to reduce the disposal of bagasse ash. | [
"Mechanics of Materials",
"Building and Construction"
] | |
Biologisch-chemische Untersuchungen an excidiertem Scheidengewebe über Glykose und Milchsäureentwicklung | [
"Obstetrics and Gynecology"
] | ||
Une édition du Tacite de Juste Lipse, avec annotations de Muret, conservée à la Mazarine | [
"Literature and Literary Theory",
"Linguistics and Language",
"History",
"Language and Linguistics"
] | ||
Apport calorique et protidique et masse osseuse | [
"Rheumatology"
] | ||
On the influence of the companion star in Eta Carinae: 2D radiative transfer modelling of the ultraviolet and optical spectra★ | [
"Space and Planetary Science",
"Astronomy and Astrophysics"
] | ||
Regulation of ecto‐NTPDase I gene expression in Trypanosoma cruzi (974.7) | The FASEB Journal | [
"Genetics",
"Molecular Biology",
"Biochemistry",
"Biotechnology"
] | |
Tagungen und Kongresse | [
"Hematology"
] | ||
Structure and Function of the Digestive Tract of a Herbivorous Lizard Iguana iguana | [
"Physiology (medical)",
"Endocrinology",
"Animal Science and Zoology",
"Physiology"
] | ||
Randomised clinical trial: safety, tolerability, pharmacokinetics and pharmacodynamics of repeated doses of TAK-438 (vonoprazan), a novel potassium-competitive acid blocker, in healthy male subjects | Alimentary Pharmacology & Therapeutics | [
"Pharmacology (medical)",
"Gastroenterology",
"Hepatology"
] | |
“Crime” in the lab-detecting social interaction | European Economic Review | [
"Economics and Econometrics",
"Finance"
] | |
Titelei | [
"Philosophy"
] | ||
Cardiovascular safety of lercanidipine in patients with angina pectoris: a review of six randomized clinical trials | Current Therapeutic Research | [
"Pharmacology (medical)",
"Pharmacology"
] |
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