Title stringlengths 0 905 | Abstract stringlengths 0 11.3k | Container_Title stringlengths 0 126 | Subject listlengths 1 13 |
|---|---|---|---|
Sequential Injection of 3% Sodium Tetradecyl Sulfate and 20% Sodium Chloride in the Treatment of Refractory Varicosity of the Greater Saphenous Vein | The Journal of Dermatologic Surgery and Oncology | [
"Dermatology",
"Oncology"
] | |
Secondary mould metabolites of Cladosporium tenuissimum, a hyperparasite of rust fungi | Phytochemistry | [
"Horticulture",
"Plant Science",
"Molecular Biology",
"Biochemistry"
] | |
Calendar of meetings | [
"Applied Mathematics",
"Computational Theory and Mathematics",
"Computational Mathematics",
"Statistics and Probability"
] | ||
Innovation and Entrepreneurship for the Diversification and Growth of the Gulf Cooperation Council Economies | The Arab States of the Gulf region have vast reserves of petroleum. The reduction in oil prices since the summer of 2014, and their volatility pose strong challenges to the six economies of the Gulf Cooperation Council (GCC). In the present contribution, we argue that, in the long-run, diversified economies perform better than mono-sector economies. Also, innovation and entrepreneurship are key drivers for the diversification and growth of GCC economies. More specifically, in this article we analyze the innovation performance of the GCC economies and we consider their innovation strategies. In addition, we provide an overview of entrepreneurship in the GCC countries to grasp its current state, aiming at identifying the conditions to foster entrepreneurship in order to develop the non-oil private sector. Finally, we discuss the policies that would be required to boost innovation and stimulate entrepreneurship in the Arab States of the Gulf with the aim of diversifying their economies and enhancing their growth. | Business and Management Studies | [
"Industrial and Manufacturing Engineering",
"Materials Science (miscellaneous)",
"Business and International Management"
] |
Lumbar spine X-rays for back pain: Still justified as a screening examination in South Africa | Standard teaching in the imaging approach to patients with back pain is that plain X-ray should only be obtained after 3 months of conservative treatment and thorough clinical examination and appropriate laboratory investigations. This approach, while appropriate in first-world countries, may lead to conditions such as tuberculosis of the spine being overlooked. An analysis was therefore made of 1 383 patients with complaints of lower back pain who were referred for X-ray of the lumbar spine. In 28 patients active spinal tuberculosis was diagnosed; in 8 of these patients the diagnosis had not been suspected clinically. It is concluded that in South Africa with its unsophisticated patient population and poor facilities, limited X-ray (lateral and AP view) of the lumbar spine is justified in patients presenting with back pain for the first time. | [
"Radiology, Nuclear Medicine and Imaging",
"Radiological and Ultrasound Technology"
] | |
Circulating Ki-67 index in plasma as a biomarker and prognostic indicator in chronic lymphocytic leukemia | [
"Cancer Research",
"Oncology",
"Hematology"
] | ||
Functional implications of spontaneous sarcoplasmic reticulum Ca2+ release in the heart | [
"Physiology (medical)",
"Cardiology and Cardiovascular Medicine",
"Physiology"
] | ||
Revisiting the apparatus: the theatre chair and cinematic spectatorship | [
"Visual Arts and Performing Arts",
"Communication",
"Cultural Studies"
] | ||
Role of MRI in Evaluation of Focal Liver Lesions: A Cross-sectional Study | Introduction: The non-invasive diagnosis of liver lesions is usually achieved with contrast material-enhanced computed tomography and Magnetic Resonance (MR) imaging. Dynamic three dimensional gradient-recalled-echo MR imaging provides dynamic contrast-enhanced thin-section images with fat saturation and a high signal-to-noise ratio and is excellent for the evaluation of various focal hepatic lesions. Aim: To explore the effectiveness and hence the clinical utility of plain and contrast MR characterisation of focal hepatic lesions in patients and their correlation with the histopathological findings. Materials and Methods: The present study was a multicenteric study done on both Inpatients and Outpatients of Department of Radiology of Tertiary care hospitals in Bengaluru, from January 2020 to August 2020. A total of 42 patients diagnosed with focal liver lesions by Ultrasonography were included in this study. Plain MRI study was done by using spin echo technique and contrast MRI study was done after rapid bolus injection (0.1 mmol/kg body weight) of gadolinium dimeglumine. Pathological and post-operative histopathological findings were noted. Microsoft excel software was used for data analysis and tables were prepared for comparison of collected data. Specificity and sensitivity were calculated for diagnostic accuracy of MRI. Results: This study included forty-two patients in total, twenty-five male and seventeen female patients, in age group of 15 to 84 years with a mean age of 48 years. Metastasis and Hepatocellular Carcinoma (HCC) were most common malignant lesions in liver while Hemangiomas were most common benign lesions followed by simple and complex cysts and hepatic adenoma. The present study calculated the specificity and sensitivity of MRI of focal hepatic lesions and correlated the findings clinically, pathologically and histopathologically. The specificity of MRI for characterisation of focal liver disease was high (90.4%). Specificity of MRI for HCC was found to be 96.7 % and that for metastasis was 97% while sensitivity for Haemangiomas is found to be 100%.MRI is superior compared to other modalities like ultrasound and CT in having high spatial resolution. Multiple sequences like T1, T2 and fat suppression techniques like IN PHASE, OUT OF PHASE helps in demonstrating lesion characters like architecture, margin, haemorrhage, fat component and vascular invasion of the lesions. Conclusion: MRI is valuable for the characterization of focal liver lesions detected on Ultrasonography. Basic MRI sequences along with chemical shift imaging sequences and dynamic contrast imaging has significant role in characterising the focal liver lesions. Despite that, It should be the modality choice for the lesions which are undetected or doubtful on ultrasound and CT examinations. | [
"Clinical Biochemistry"
] | |
HCudaBLAST: an implementation of BLAST on Hadoop and Cuda | [
"Information Systems and Management",
"Computer Networks and Communications",
"Hardware and Architecture",
"Information Systems"
] | ||
Recent Technological Advancement in Surrounding Gate MOSFET for Biosensing Applications - a Synoptic Study | Silicon | [
"Electronic, Optical and Magnetic Materials"
] | |
Technical and economical aspects of solar desalination with particular emphasis on solar pond powered distillation plants | [
"Mechanical Engineering",
"Water Science and Technology"
] | ||
TCTAP C-067 Successful PCI for CTO via the Previous Implanted Stent Strut in CPA Patient Treated with Hemodialysis | Journal of the American College of Cardiology | [
"Cardiology and Cardiovascular Medicine"
] | |
Control y prevención de las enfermedades cardiovasculares en el mundo | [
"Cardiology and Cardiovascular Medicine"
] | ||
Minimally Invasive Left Ventricular Assist Device Insertion Facilitates Subsequent Heart Transplant | Objective We have observed that minimally invasive left ventricular assist device (LVAD) insertion leads to more facile re-entry and easier cardiac transplantation. We hypothesize minimally invasive LVAD implantation results in improved outcomes at the time of subsequent heart transplant. Methods All adults undergoing cardiac transplantation between October 2015 and March 2019 at our institution were retrospectively reviewed. Those bridged to transplantation with a HeartWare HVAD were identified and divided into 2 cohorts based upon the surgical approach: those who underwent HVAD placement by conventional sternotomy versus minimally invasive insertion via lateral thoracotomy and hemisternotomy (LTHS). Patient demographics, as well as perioperative transplant outcomes, including survival, length of stay (LOS), blood utilization, ischemic time, bypass time, and postoperative extracorporeal membrane oxygenation (ECMO) were compared between cohorts. Results Forty-two patients were bridged to heart transplant with a HVAD implanted via either sternotomy ( n = 22) or LTHS technique ( n = 20). Demographics were similar between groups. There was 1 predischarge death in the sternotomy group and none in the LTHS group. Body surface area, cardiopulmonary bypass time, ischemic time, ECMO utilization, and reoperation for bleeding were similar. Red blood cell units transfused were significantly lower in the LTHS cohort (3.0 [1.0-5.0] vs 6.0 [2.5-10.0] P = 0.046). The LTHS cohort had a significantly shorter hospital LOS (12.0 [11.0-28.0] vs 22.5 [15.7-41.7] P = 0.022) with a trend toward shorter intensive care unit LOS (6.0 [5.0-10.5] vs 11.0 [6.0-21.5] days P = 0.057). Conclusions Minimally invasive HVAD implantation improves outcomes at subsequent heart transplantation, resulting in shorter LOS and less red cell transfusion. Larger multi-institutional studies are necessary to validate these findings. | [
"Cardiology and Cardiovascular Medicine",
"Surgery",
"Pulmonary and Respiratory Medicine"
] | |
InfoSec Process Action Model (IPAM) | While much of the extant InfoSec research relies on single assessment models that predict intent to act, this article proposes a multi-stage InfoSec Process Action Model (IPAM) that can positively change individual InfoSec behavior. We believe that this model will allow InfoSec researchers to focus more directly on the process that leads to action and develop better interventions that address problematic security behaviors. Building on successful healthcare efforts that resulted in smoking cessation, regular exercise, and a healthier diet, among others, IPAM is a hybrid predictive process approach to behavioral InfoSec improvement. IPAM formulates the motivational antecedents of intent as separate from the volitional drivers of behavior. Singular fear appeals often seen in InfoSec research are replaced by more nuanced treatments appropriately differentiated to support behavioral change as part of a process; phase-appropriate measures of self-efficacy are employed to more precisely assess the likelihood that a participant will act on good intentions; and decisional balance assessment of pro and con perceptions is monitored over time. These notions better align InfoSec research with both leading security practice and successful comparators in healthcare. We believe IPAM can both help InfoSec research models better explain actual behavior and better inform practical security behavior improvement initiatives. | [
"Computer Networks and Communications",
"Management Information Systems"
] | |
Relation between projective geometry and group contraction in spontaneously broken symmetry theories | [
"Nuclear and High Energy Physics"
] | ||
Participative service redesign using appreciative inquiry | Approaches to the development of strategy within the context of change vary in both style and success. A participatory approach to change provides everyone involved in the process with the opportunity to share their experience and knowledge, explore common values and create something they can have shared ownership of and responsibility for. The challenges to management are often around their perceived position of power, their need to control and plan the change process and the concept that ideas are best generated by experts. | [
"Rehabilitation",
"Physical Therapy, Sports Therapy and Rehabilitation"
] | |
Sensitive Electrochemical Detection of Dopamine, Uric and Ascorbic Acids Based on poly-(Dianix Yellow) Film Modified Electrode | International Journal of Electrochemical Science | [
"Electrochemistry"
] | |
Numerical analysis of a slope stabilized with piles and anchor cable frame beams | [
"Earth-Surface Processes",
"Geology",
"Pollution",
"Soil Science",
"Water Science and Technology",
"Environmental Chemistry",
"Global and Planetary Change"
] | ||
Indian Media Framing of the Image of Muslims | [
"Social Sciences (miscellaneous)",
"Linguistics and Language",
"Communication"
] | ||
Fecundity of the mirror carp Cyprinus carpio L. at the Serow Fish Farm (Egypt) | [
"Aquatic Science"
] | ||
Registro Alemán de la Disección Aguda de Aorta Tipo A (GERAADA) | Cirugía Cardiovascular | [
"Cardiology and Cardiovascular Medicine",
"Surgery"
] | |
Early response to immunosuppressive therapy predicts good renal outcome in lupus nephritis: Lessons from long-term followup of patients in the Euro-Lupus Nephritis Trial | [
"Pharmacology (medical)",
"Immunology",
"Rheumatology",
"Immunology and Allergy"
] | ||
Vladimir M. Mirsky (Ed.): Ultrathin Electrochemical Chemo- and Biosensors: Technology and Performance | Analytical and Bioanalytical Chemistry | [
"Biochemistry",
"Analytical Chemistry"
] | |
Ammonia line strengths and N2-, O2-, Ar-, He-, and self-broadening coefficients in the v2 band near 10.4 µm | Journal of Quantitative Spectroscopy and Radiative Transfer | [
"Spectroscopy",
"Atomic and Molecular Physics, and Optics",
"Radiation"
] | |
Comparative Studies of the Ethynyl Estrogens used in Oral Contraceptives. VI. Effects with and without Progestational Agents on Carbohydrate Metabolism in Humans, Baboons, and Beagles | Fertility and Sterility | [
"Obstetrics and Gynecology",
"Reproductive Medicine"
] | |
Endocrine Problems During Pregnancy | [
"Anesthesiology and Pain Medicine"
] | ||
INCUBATING INNOVATION | Companies must leverage the full spectrum of innovation, from the incremental to the revolutionary. | Journal of Business Strategy | [
"Strategy and Management",
"Management Information Systems"
] |
Cycling toward Elimination of Leukemic Stem Cells | Cell Stem Cell | [
"Cell Biology",
"Genetics",
"Molecular Medicine"
] | |
Issues with analyzing noble gases using gas chromatography with thermal conductivity detection | Analytical and Bioanalytical Chemistry | [
"Biochemistry",
"Analytical Chemistry"
] | |
The Chemistry of N-Substituted Pyridinium Salts | [
"Organic Chemistry",
"Pharmacology",
"Analytical Chemistry"
] | ||
Macroeconomic Determinants of Household Debt in OECD Countries | This article investigates the macroeconomic determinants of household debt in developed economies using a sample comprising 26 OECD countries for the period of 2002q1–2020q4. By resorting to the unconditional quantile regression, we find relevant asymmetries in the response of household debt. According to our results, economic growth leads to lower household debt, but the beneficial effect decreases as the level of household debt increases. Inflation lowers household borrowing only if the level of debt is high. Higher house prices lead to higher household debt, with the impact becoming stronger as the level of debt is higher. Investments go hand in hand with household debt, and higher investments lead to higher levels of borrowing, even when household debt is already high. Mortgage credit interest rates are positively linked with household debt, starting with higher debt levels. A rising unemployment rate leads to lower household debt, but the link becomes weaker as the level of debt increases. Higher public expenditures are generally associated with lower household debt. In addition, we find that household debt exhibits very powerful autoregressive behavior, being difficult to reduce rapidly in the case of need. | Sustainability | [
"Management, Monitoring, Policy and Law",
"Renewable Energy, Sustainability and the Environment",
"Geography, Planning and Development"
] |
Microprobe Analysis of Ocher On Bone from The Anzick Burial Site | [
"Anthropology"
] | ||
Characterising the effects of high ammonia emission on the growth of Norway spruce | Plant and Soil | [
"Plant Science",
"Soil Science"
] | |
SEM-studies of the xylem of diseased oak trees growing in the Krotoszyn Plateau | [
"Ecology",
"Forestry"
] | ||
Thermal photons from heavy ion collisions: A spectral function approach | Physical Review C | [
"Nuclear and High Energy Physics"
] | |
Sliding stability analysis of gravity retaining walls using the pseudo-dynamic method | The sliding stability of gravity retaining walls for the dynamic active case is studied using the pseudo-dynamic method. After rectifying the wall inertia equations, the pseudo-static method of Richards and Elms is compared with the present pseudo-dynamic method in the active case. Comparison of the two methods for the same combination of input parameters indicates that the pseudo-static method and the pseudo-dynamic method predict the same value of combined dynamic factor (FW) for the low range of horizontal seismic acceleration coefficient kh. However, for higher values of kh, the pseudo-static method overestimates the value of FW compared with the pseudo-dynamic method. Using the pseudo-dynamic method, it is observed that the maximum values of the stability factors (the soil active thrust factor FT, the wall inertia factor FI and FW) do not occur simultaneously during the application of input motions. When FW is at its maximum value (which is the sliding stability criterion), other factors are not at their maximum values, and thus multiplying the maximum of the partial factors causes overestimation of FW in the pseudo-static method. Comparing the predictions of the pseudo-dynamic method with the experimental results confirms that use of the pseudo-static method for seismic design of retaining walls may be over-conservative, especially for high values of peak ground motions. | [
"Earth and Planetary Sciences (miscellaneous)",
"Geotechnical Engineering and Engineering Geology"
] | |
Distillation of Gaussian Einstein-Podolsky-Rosen steering with noiseless linear amplification | AbstractEinstein–Podolsky–Rosen (EPR) steering is one of the most intriguing features of quantum mechanics and an important resource for quantum communication. For practical applications, it remains a challenge to protect EPR steering from decoherence due to its intrinsic difference from entanglement. Here, we experimentally demonstrate the distillation of Gaussian EPR steering and entanglement in lossy and noisy environments using measurement-based noiseless linear amplification. Different from entanglement distillation, the extension of steerable region happens in the distillation of EPR steering, besides the enhancement of steerabilities. We demonstrate that the two-way or one-way steerable region is extended after the distillation of EPR steering when the NLA is implemented based on Bob’s or Alice’s measurement results. We also show that the NLA helps to extract the secret key from the insecure region in one-sided device-independent quantum key distribution with EPR steering. Our work paves the way for quantum communication exploiting EPR steering in practical quantum channels. | npj Quantum Information | [
"Computational Theory and Mathematics",
"Computer Networks and Communications",
"Statistical and Nonlinear Physics",
"Computer Science (miscellaneous)"
] |
The acoustofluidic focusing and separation of rare tumor cells using transparent lithium niobate transducers | Research on circulating tumor cells (CTCs) is of great significance in cancer diagnosis, prognosis and even the development of personalized therapy. | [
"Biomedical Engineering",
"Biochemistry",
"Bioengineering"
] | |
4th Biennial Scottish Conference on the diabetic foot | [
"Endocrinology, Diabetes and Metabolism",
"Internal Medicine"
] | ||
The “Subjects” of Ottoman International Law | [
"Law",
"Religious Studies",
"Anthropology",
"History",
"Cultural Studies"
] | ||
Characteristics of high-performance anti-corrosion/anti-wear ceramic coatings on magnesium‑lithium alloy by plasma electrolytic oxidation surface engineering | [
"Materials Chemistry",
"Surfaces, Coatings and Films",
"Surfaces and Interfaces",
"Condensed Matter Physics"
] | ||
Defining Patient-Specific Risk in Acute Myeloid Leukemia | Journal of Clinical Oncology | [
"Cancer Research",
"Oncology"
] | |
Enrollment Management and Career Services: Translating Concepts into Practice | [
"Organizational Behavior and Human Resource Management",
"Applied Psychology",
"Education"
] | ||
Ice Shelf Basal Melt and Influence on Dense Water Outflow in the Southern Weddell Sea | [
"Earth and Planetary Sciences (miscellaneous)",
"Space and Planetary Science",
"Geochemistry and Petrology",
"Geophysics",
"Oceanography"
] | ||
Event related potential manifestations of the oblique effect | [
"Physiology (medical)",
"Neuropsychology and Physiological Psychology"
] | ||
Adult Vitelliform Macular Detachment Occurring in Patients with Basal Laminar Drusen | [
"Ophthalmology"
] | ||
The Provision of Assistance to Small Firms | Douglas Ritchie, David Asch and Alastair Weir lecture at the Humberside College of Higher Education, United Kingdon. This note reports on the initial findings of an extensive research study into the provision of help and support for small firms, its wide diversity, and its effectiveness. | International Small Business Journal: Researching Entrepreneurship | [
"Business and International Management"
] |
Effects of drought stress on the seedling growth, development, and metabolic activity in different cultivars of canola | [
"Plant Science",
"Soil Science"
] | ||
Tetrabenazine | Expert Opinion on Pharmacotherapy | [
"Pharmacology (medical)",
"Pharmacology"
] | |
Quodvultdeus of Carthage: The Creedal Homilies. Conversion in Fifth-Century North Africa â By Thomas Macy Finn | [
"Religious Studies"
] | ||
The Definition of Diversity | [
"Library and Information Sciences",
"Public Administration"
] | ||
A method for computation of the discrete Fourier transform over a finite field | [
"Computer Networks and Communications",
"Computer Science Applications",
"Information Systems"
] | ||
Fetal nutritional status: diagnosis and future perspectives | Ultrasound in Obstetrics and Gynecology | [
"Obstetrics and Gynecology",
"Radiology, Nuclear Medicine and Imaging",
"Reproductive Medicine",
"Radiological and Ultrasound Technology"
] | |
Experimental insights on the coordination modes of coumarin-3-carboxilic acid towards Cr(III)-, Co(II)-, Ni(II)-, Cu(II)- and Zn(II): A detailed potentiometric and spectroscopic investigation in aqueous media | [
"Materials Chemistry",
"Physical and Theoretical Chemistry",
"Spectroscopy",
"Condensed Matter Physics",
"Atomic and Molecular Physics, and Optics",
"Electronic, Optical and Magnetic Materials"
] | ||
Delayed Diagnosis of TSH-Secreting Adenoma Attributed to Worsening Post-Traumatic Stress Disorder Symptoms in a Military Veteran Because of Provider Anchoring Bias | Military Medicine | [
"Public Health, Environmental and Occupational Health"
] | |
Redefining the Cut-Off Ranges for TSH Based on the Clinical Picture, Results of Neuroimaging and Laboratory Tests in Unsupervised Cluster Analysis as Individualized Diagnosis of Early Schizophrenia | Thyroid abnormalities, including mild forms of hypothyroidism and hyperthyroidism, are reported as risk factors for the development of a number of neuropsychiatric disorders, including schizophrenia. The diagnostic process still takes into account the extreme ranges of the accepted reference values for serum TSH since the concentration of free thyroxine in the serum does not change by definition. TSH mU/L cut-off values in psychiatric patients are currently clinically considered in the case of extremely high serum TSH levels (>4.0 mU/L). The results obtained in this study suggest that the clinically significant value has a lower TSH cut-off point with an upper limit of 2–2.5 mU/L. The criteria for the differential diagnosis of patients with schizophrenia, however, mainly take into account statutory reference ranges without a background related to the history of thyroid diseases in the family. The results indicate the need to lower the upper cut-off values for TSH among patients with early psychosis, which is related to the potential clinical significance of the obtained values both in the field of clinical evaluation and neuroimaging and laboratory evaluation parameters. The cut-off points obtained with the prior available knowledge coincided with the values established in the unsupervised clustering method, which further confirms the legitimacy of their use in the individualized diagnosis strategy of schizophrenia. | [
"Medicine (miscellaneous)"
] | |
Using teleconsultation to enhance the care of patients with acute burns | [
"Health Policy",
"Sociology and Political Science",
"Health (social science)"
] | ||
The three-dimensional structure ofEscherichia coliporphobilinogen deaminase at 1.76-Å resolution | Proteins: Structure, Function, and Bioinformatics | [
"Molecular Biology",
"Biochemistry",
"Structural Biology"
] | |
Alzheimer disease: Evidence for a central pathogenic role of iron-mediated reactive oxygen species | Journal of Alzheimer's Disease | [
"Psychiatry and Mental Health",
"Geriatrics and Gerontology",
"Clinical Psychology"
] | |
Analysis of predictability and accountability transparency practices and FTA on trade growth in selected countries of the Asia-Pacific region: a descriptive-causal approach | [
"Economics, Econometrics and Finance (miscellaneous)",
"Economics and Econometrics"
] | ||
Investigation on inlet obstruction in transitional flow regime: Heat transfer augmentation and pressure drop analysis | [
"Fluid Flow and Transfer Processes",
"Engineering (miscellaneous)"
] | ||
Report of 729 obstetrical cases in Chungking | [
"Obstetrics and Gynecology"
] | ||
POS0197 RESPONSIVENESS OF ULTRASOUND SYNOVITIS AND CLINICAL OUTCOMES IN PSORIATIC ARTHRITIS TREATED WITH SECUKINUMAB: DATA FROM THE ULTIMATE TRIAL | Background:Power Doppler ultrasonography is a sensitive imaging tool to assess synovitis in psoriatic arthritis (PsA).1,2 ULTIMATE (NCT02662985) is the first large, randomised, double-blind placebo-controlled phase IIIb study in PsA, using ultrasound to evaluate early response to secukinumab on synovitis. The use of the standardised and reliable global EULAR-OMERACT composite ultrasound synovitis score at patient level (GLOESS) as the primary endpoint showed the early and significant benefit of secukinumab vs. placebo on synovitis at week 12.3Objectives:To investigate the responsiveness and discriminative validity of GLOESS compared to clinical outcomes on joints at week 12 and report ultrasound and clinical efficacy data up to week 24.Methods:This is a 52-week study with a 12-week double-blind, placebo-controlled period followed by 12-week open-label (OL) and 6-month OL extension. All placebo patients were switched to secukinumab (300 or 150 mg) at week 12.3 Discriminative validity of GLOESS was analysed post-hoc: within-group responsiveness was assessed by comparing its standardised response mean (SRM) to that of core set of ACR response in the initial secukinumab group over 12 and 24 weeks. Mean change from baseline up to week 12 of GLOESS was determined with mixed-effect model repeated measures analysis (MMRM) and from week 12-24 as observed. 24 week efficacy outcomes included ACR responses, HAQ-DI, PASI response and resolution of dactylitis. These outcomes were exploratory and reported either according to non-responder imputation (ACR response), or as observed (HAQ-DI, PASI response and resolution of dactylitis).Results:Of 166 patients enrolled, a total of 155 patients (93%) completed 24 weeks of treatment (secukinumab, 79 patients 95%; placebo, 76 patients 92%). Mean change from baseline to week 24 in GLOESS was similar in the initial secukinumab and placebo-secukinumab groups. A continued improvement in GLOESS was observed in the secukinumab group, with catch-up improvement in the placebo group after switch to active therapy (Figure 1). Both SRM of GLOESS and ACR core components over 12 and 24 weeks were high (Table 1). Similar clinical response rates were reported for clinical joint count, skin, dactylitis and function at week 24 in secukinumab and placebo switchers groups (Table 1).Conclusion:These analyses highlight the responsiveness and high discriminative validity of GLOESS in PsA, resembling that of key clinical PsA manifestations and physical function.References:[1]D’Agostino MA and Coates LC. J Rheumatol. 2019;46:337–9.[2]Uson J, et al. Rheumatol Clin. 2018;14:27–35.[3]D’Agostino MA, et al. Arthritis Rheumatol. 2020;72 (suppl 10).Figure 1.Mean change from baseline in GLOESS by treatment through Week 24Table 1.Responsiveness of GLOESS - analysed by standardised response mean and efficacy outcomes at week 24Standardised response mean(Initial secukinumab)Efficacy of secukinumabWeek0–12(N = 83)Week0–24(N = 83)Responders(%)Secukinumabweek 0–24(N = 83)Placebo switchersweek 12–24(N = 83)GLOESS1.051.06ACR208774Tender joint count1.031.35ACR506449Swollen joint count0.911.18ACR703423Patient global assessment of disease activity1.371.55HAQ-DI*8063Physician global assessment of disease activity1.592.39PASI 75†7259Pain1.321.53PASI 90†6245HAQ-DI score1.321.32Resolutionof dactylitis (LDI=0)6759*HAQ-DI response is defined as an improvement of at least 0.35 score points compared to baseline (change ≤ −0.35)†N value for PASI response in secukinumab and placebo groups are 36 and 33; respectively. PASI response was calculated for patients with BSA ≥ 3 %.BSA, Body Surface Area; LDI, Leeds Dactylitis IndexDisclosure of Interests:Maarten Boers Consultant of: BMS, Novartis, Pfizer, GSK, Philip G Conaghan Speakers bureau: AbbVie, AstraZeneca, BMS, Eli Lilly, Galapagos, Gilead, Novartis and Pfizer, Consultant of: AbbVie, AstraZeneca, BMS, Eli Lilly, Galapagos, Gilead, Novartis and Pfizer, Georg Schett Speakers bureau: AbbVie, BMS, Celgene, Janssen, Eli Lilly, Novartis, Roche and UCB, Peter Mandl Speakers bureau: AbbVie, BMS, Celgene, Janssen, Eli Lilly, MSD, Novartis, Roche and UCB, Grant/research support from: AbbVie, BMS, Celgene, Janssen, Eli Lilly, MSD, Novartis, Roche and UCB, Esperanza Naredo Speakers bureau: AbbVie, Roche, BMS, Pfizer, UCB, Eli Lilly, Novartis, Janssen, and Celgene, Consultant of: AbbVie, Novartis and BMS, Grant/research support from: Eli Lilly, Filip van den Bosch Speakers bureau: AbbVie, Celgene, Janssen, Eli Lilly, Galapagos, Merck, Novartis, Pfizer, and UCB Pharma, Consultant of: AbbVie, Celgene, Janssen, Eli Lilly, Galapagos, Merck, Novartis, Pfizer, and UCB Pharma, Ruben Burgos-Vargas: None declared, Anne-Marie Duggan Employee of: Novartis, Punit Goyanka Employee of: Novartis, Corine Gaillez Shareholder of: Novartis and BMS, Employee of: Novartis, Maria-Antonietta D’Agostino Speakers bureau: Sanofi, Novartis, BMS, Janssen, Celgene, Roche, AbbVie, UCB, and Eli Lilly, Consultant of: Sanofi, Novartis, BMS, Janssen, Celgene, Roche, AbbVie, UCB, and Eli Lilly | [
"Immunology",
"Immunology and Allergy",
"Rheumatology"
] | |
Identification of Listeria monocytogenes Genes Expressed in Response to Growth at Low Temperature | ABSTRACT Listeria monocytogenes is a food-borne bacterial pathogen that is able to grow at refrigeration temperatures. To investigate microbial gene expression associated with cold acclimation, we used a differential cDNA cloning procedure known as selective capture of transcribed sequences (SCOTS) to identify bacterial RNAs that were expressed at elevated levels in bacteria grown at 10°C compared to those grown at 37°C. A total of 24 different cDNA clones corresponding to open reading frames in the L. monocytogenes strain EGD-e genome were obtained by SCOTS. These included cDNAs for L. monocytogenes genes involved in previously described cold-adaptive responses ( flaA and flp ), regulatory adaptive responses ( rpoN , lhkA , yycJ , bglG , adaB , and psr ), general microbial stress responses ( groEL , clpP , clpB , flp , and trxB ), amino acid metabolism ( hisJ , trpG , cysS , and aroA ), cell surface alterations ( fbp , psr , and flaA ), and degradative metabolism ( eutB , celD , and mleA ). Four additional cDNAs were obtained corresponding to genes potentially unique to L. monocytogenes and showing no significant similarity to any other previously described genes. Northern blot analyses confirmed increased steady-state levels of RNA for all members of a subset of genes examined during growth at a low temperature. These results indicated that L. monocytogenes acclimation to growth at 10°C likely involves amino acid starvation, oxidative stress, aberrant protein synthesis, cell surface remodeling, alterations in degradative metabolism, and induction of global regulatory responses. | [
"Ecology",
"Applied Microbiology and Biotechnology",
"Food Science",
"Biotechnology"
] | |
Delineation of Groundwater Potential and Recharge Zone Using Electrical Resistivity Method Around Veeranam Tank, Tamil Nadu, India | Journal of The Institution of Engineers (India): Series A | [
"Mechanical Engineering",
"Agricultural and Biological Sciences (miscellaneous)",
"Building and Construction",
"Civil and Structural Engineering",
"Architecture"
] | |
Hand-twistable plastically deformable crystals of a rigid small organic molecule | The crystals of the small rigid molecule 4-bromobenzonitrile exhibit highly flexible plastic bending behaviour that occurs on two perpendicular faces of the crystal, a rare situation, leading to the formation of helical/twisted and curled crystals. | [
"Materials Chemistry",
"Metals and Alloys",
"Surfaces, Coatings and Films",
"Ceramics and Composites",
"Electronic, Optical and Magnetic Materials",
"Catalysis"
] | |
MHN DROUSILLHOS | [
"Archeology",
"History"
] | ||
Buchbesprechungen – Book Reviews – Livres nouveaux | [
"Nutrition and Dietetics",
"Medicine (miscellaneous)"
] | ||
Detection of a narrow-band noise as a function of its interaural correlation | Psychonomic Science | [
"Catalysis"
] | |
An experimental study of multiple-choice and open-ended tests in physics | Journal of Research in Science Teaching | [
"Education"
] | |
Liberation Theology in Tanzania and South Africa: A First World interpretation | [
"Sociology and Political Science",
"Geography, Planning and Development"
] | ||
Client-server trends | [
"Electrical and Electronic Engineering"
] | ||
On Nature and the Human | [
"Arts and Humanities (miscellaneous)",
"Anthropology"
] | ||
Long-term efficacy and cost-effectiveness of infliximab as first-line treatment in rheumatoid arthritis: systematic review and meta-analysis | [
"Pharmacology (medical)",
"Health Policy"
] | ||
Object Tracking Based on the Fusion of Roadside LiDAR and Camera Data | IEEE Transactions on Instrumentation and Measurement | [
"Electrical and Electronic Engineering",
"Instrumentation"
] | |
Characterization of aerosol optical depth, aerosol mass concentration, UV irradiance and black carbon aerosols over Indo-Gangetic plains, India, during fog period | [
"Atmospheric Science"
] | ||
A FOLLOW-UP STUDY OF A CHILDPSYCHIATRIC CLIENTELE, WITH SPECIAL REGARD TO THE INCIDENCE OF PSYCHOSIS | [
"Psychiatry and Mental Health"
] | ||
Macroalgal treatment to alleviate the strawberry yield loss caused by Macrophomina phaseolina (Tassi) Goid. in greenhouse cultivation system | The application of algae has been considered a key element for integrated disease management in sustainable agriculture. These organisms can act as a bio-stimulant for induction of resistance against a variety of abiotic and biotic agents that cause economical loss to crop production globally. Charcoal rot disease caused by Macrophomina phaseolina (Tassi) Goid. is one of the biotic agents restricting strawberry (Fragaria × ananassa Duch.) yield in many cultivation sites. Herein, the foliar application of brown alga (Sargassum angustifolium) was investigated for the reduction of the disease symptoms and improvement of vegetative and reproductive indices in strawberries under greenhouse conditions. The results showed that alga-treated infected plants showed symptom remission. Moreover, vegetative and reproductive indices of alga-treated plants were significantly improved. Biochemical analysis showed that in alga-treated infected plants the total phenol, flavonoids, and total antioxidant activity were significantly increased compared to non-treated infected plants. Furthermore, the content of defense-related enzymes, viz. phenylalanine ammonia-lyase and polyphenol oxidase, were significantly increased in the infected plants pre-treated with the alga extract. Foliar application of S. angustifolium extract can induce defense responses in strawberry plants infected by M. phaseolina leading to improved growth indices of the plants. It can be concluded that S. angustifolium extract is a promising source of bio-stimulants for induction of disease resistance against charcoal rot disease in strawberry cultivations. | [
"Horticulture",
"Management, Monitoring, Policy and Law",
"Agronomy and Crop Science",
"Ecology",
"Food Science",
"Global and Planetary Change"
] | |
PROCEEDINGS OF THE PHYSIOLOGICAL SOCIETY | [
"Physiology"
] | ||
When the means modify the ends. (E)Valuating and transforming the purpose of a nonprofit organization through impact assessment. | In a context marked by a trend towards marketization and a rise in performance measures, nonprofit organizations (NPOs) suffer pressures to show that their activities have visible impacts. Based on the French pragmatist sociology’s Economies of Worth framework, we explore how NPOs may come to change what they value and what is their fundamental purpose. More specifically, we delve into the process of valuation triggered by the intervention of consultants to help a NPO develop an impact evaluation tool aimed at legitimizing its actions. Our findings show how this process led to a complete redefinition of the NPO’s “theory of change”, ultimately distantiating the NPO from its initial, explicit purposes. | Canadian Journal of Nonprofit and Social Economy Research | [
"Literature and Literary Theory",
"History",
"Cultural Studies"
] |
Catalytic pyrolysis of polyethylene: A comparison between pillared and restructured clays | Journal of Analytical and Applied Pyrolysis | [
"Analytical Chemistry",
"Fuel Technology"
] | |
Validation of the Intention Attribution Test for Children (IAC) | The Intention Attribution Test for Children (IAC) was created to assess hostile attribution bias in preschool- and early school-aged children. It comprises 16 cartoon strips presenting situations in which one character (either a child or an adult) causes harm to another, either intentionally, accidentally (nonintentional), or without his or her intention being clear (ambiguous). Its validity was tested on 233 children aged 4 to 12 years. Exploratory factor analysis and item response theory models demonstrated support for a single factor of hostile attribution bias for the ambiguous and nonintentional items. Analyses revealed, however, that the intentional items did not contribute to this same overall construct of hostile intention attribution bias. Correlations with the Social Perception Test and with sociometry suggest good validity of the IAC. The IAC may be a useful instrument for research and in the context of therapeutic intervention addressing socially inappropriate behavior in childhood. | Assessment | [
"Applied Psychology",
"Clinical Psychology"
] |
Exploration of a Ce0.65Zr0.25Pr0.1O2−δ-Based Electrocatalyst That Exhibits Rapid Performance Deterioration Despite Its High Oxygen Storage Capability | [
"Electrical and Electronic Engineering",
"Materials Chemistry",
"Electrochemistry",
"Energy Engineering and Power Technology",
"Chemical Engineering (miscellaneous)"
] | ||
The Poison Paradox | [
"Pharmacology (medical)",
"Pharmacology"
] | ||
Accuracy of Computerized Tomography in the Diagnosis of Colovesical Fistula Secondary to Diverticular Disease | [
"Urology"
] | ||
Properties of the multiscale maxima and zero-crossings representations | [
"Electrical and Electronic Engineering",
"Signal Processing"
] | ||
Adsorption of molybdate and tetrathiomolybdate onto pyrite and goethite: Effect of pH and competitive anions | [
"Environmental Chemistry",
"Environmental Engineering",
"Pollution",
"Health, Toxicology and Mutagenesis",
"Public Health, Environmental and Occupational Health"
] | ||
Synthesis, characterization, and reactivity of alkoxo complexes containing Cp*M(NO) groups (M = molybdenum, tungsten) | [
"Inorganic Chemistry",
"Organic Chemistry",
"Physical and Theoretical Chemistry"
] | ||
Effects of age, phenobarbital, β-naphthoflavone and dexamethasone on rat hepatic heme oxygenase | [
"Health, Toxicology and Mutagenesis",
"Toxicology"
] | ||
Rectified Diffusion under Adiabatic Conditions | The Journal of the Acoustical Society of America | [
"Acoustics and Ultrasonics",
"Arts and Humanities (miscellaneous)"
] | |
Elimination of tertiary .alpha. hydrogens from tosylhydrazones with lithium diisopropylamide: preparation of trisubstituted alkenes | [
"Organic Chemistry"
] | ||
Behavior Matters | American Journal of Preventive Medicine | [
"Public Health, Environmental and Occupational Health",
"Epidemiology"
] | |
Activated microglia provide a neuroprotective role by balancing glial cell-line derived neurotrophic factor and tumor necrosis factor-α secretion after subacute cerebral ischemia | [
"Genetics"
] | ||
REVIEW: Practical Physics by T. G. Bedford | [
"Space and Planetary Science",
"Astronomy and Astrophysics"
] | ||
Visual Neuroscience is soliciting papers for a feature issue: Comparative, ecological, and development aspects of visual system design and function | [
"Sensory Systems",
"Physiology"
] | ||
In Silico Identification of Conserved MiRNAs from Physcomitrella patens ESTs and their Target Characterization | Background: MicroRNAs (miRNAs) are groups of small non-protein-coding endogenous single stranded RNAs with approximately 18-24 nucleotides in length. High evolutionary sequence conservation of miRNAs among plant species and availability of powerful computational tools allow identification of new orthologs and paralogs. Methods: New conserved miRNAs in P. patens were found by EST-based homology search approaches. All candidates were screened according to a series of miRNA filtering criteria. Unigene, DFCI Gene Index (PpspGI) databases and psRNATarget algorithm were applied to identify target transcripts using P. patens putative conserved miRNA sequences. Results: Nineteen conserved P. patens miRNAs were identified. The sequences were homologous to known reference plant mature miRNA from 10 miRNA families. They could be folded into the typical miRNA secondary structures. RepeatMasker algorithm demonstrated that ppt-miR2919e and pptmiR1533 had simple sequence repeats in their sequences. Target sites (49 genes) were identified for 7 out of 19 miRNAs. GO and KEGG analysis of targets indicated the involvement of some in important multiple biological and metabolic processes. Conclusion: The majority of the registered miRNAs in databases were predicted by computational approaches while many more have remained unknown. Due to the conserved nature of miRNAs in plant species from closely to distantly related, homology search-based approaches between plants species could lead to the identification of novel miRNAs in other plant species providing baseline information for further search about the biological functions and evolution of miRNAs. | Current Bioinformatics | [
"Computational Mathematics",
"Genetics",
"Molecular Biology",
"Biochemistry"
] |
Hidden dangers | [
"LPN and LVN",
"Advanced and Specialized Nursing",
"Assessment and Diagnosis",
"Critical Care Nursing",
"Emergency Nursing"
] | ||
Response | [
"Health Policy",
"Issues, Ethics and Legal Aspects",
"Health (social science)"
] |
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