Title stringlengths 0 905 | Abstract stringlengths 0 11.3k | Container_Title stringlengths 0 126 | Subject listlengths 1 13 |
|---|---|---|---|
The four transitions in Bulgarian education | [
"Linguistics and Language",
"Language and Linguistics"
] | ||
Unrecognised and untreated depression in geriatric patients with hip fractures | [
"Psychiatry and Mental Health",
"Geriatrics and Gerontology"
] | ||
Body shape classification of Korean middle-aged women using 3D anthropometry | AbstractMost Korean apparel companies lack suitable dress forms for the different body types of middle-aged Korean women, resulting in poor clothing fit for them. As a part of an ongoing project to develop a dress form that fully reflects Korean middle-aged women’s bodies, this study classified the body shapes and examined the anthropometric characteristics of women in their 40s and 50s. The 3D anthropometric data of 302 middle-aged women of normal weight (18.5 ≤ BMI | [
"Marketing",
"Strategy and Management",
"Materials Science (miscellaneous)",
"Cultural Studies",
"Social Psychology"
] | |
Fracture Paths from Front Kinetics: Relaxation and Rate Independence | [
"Mechanical Engineering",
"Mathematics (miscellaneous)",
"Analysis"
] | ||
Brief Overview of This Month's JACI | Journal of Allergy and Clinical Immunology | [
"Immunology",
"Immunology and Allergy"
] | |
Use of the CTrach Laryngeal Mask Airway in adult patients: a retrospective review of 126 cases | Journal of Clinical Anesthesia | [
"Anesthesiology and Pain Medicine"
] | |
The effects of doxycycline on semen parameters | [
"Obstetrics and Gynecology",
"Reproductive Medicine"
] | ||
Three‐dimensional Random Dielectric Colloid Metamaterial with Giant Isotropic Optical Activity | [
"Condensed Matter Physics",
"Atomic and Molecular Physics, and Optics",
"Electronic, Optical and Magnetic Materials"
] | ||
Hemicelluloses-based sprayable and biodegradable pesticide mulch films for Chinese cabbage growth | [
"Molecular Biology",
"Biochemistry",
"Structural Biology"
] | ||
How Mössbauer spectroscopy can be of value to industry to select extraterrestrial objects for natural resources | AbstractSpace agencies are working on the project of capturing asteroids which contain natural resources valuable for industry. Based on studies of meteorites samples it was determined that the most useful source of raw materials for this purpose could be parent bodies of ordinary chondrites of type H. The identification of the type of ordinary chondrites with the use of a classical method (determination of the Fa/Fs ratio (fayalite versus ferrosilite) by electron microprobe measurements) cannot be performed on the surface of asteroids due to technical reasons. It may, however, be done based on Mössbauer measurements followed by the application of the 4M method. The name of the method – 4M, comes from four words: Meteorites, Mössbauer spectroscopy, Multidimensional discriminant analysis and Mahalanobis distance. Following the success of Mössbauer spectroscopy in the mission on Mars, there are suggestions to use the same method for the investigation of the surface of asteroids. In our experimental study, in which five Mössbauer laboratories took part, we assessed the effectiveness and reliability of the 4M method by comparison of the results obtained by Mössbauer studies of ordinary chondrites of type H, L and LL. Details of the study and problems related to the effectiveness of the 4M method are discussed. | [
"Physical and Theoretical Chemistry",
"Condensed Matter Physics",
"Nuclear and High Energy Physics",
"Atomic and Molecular Physics, and Optics"
] | |
Assessment of the Mechanisms for Sr-90 and TRU Removal from Complexant-Containing Tank Wastes at Hanford | Separation Science and Technology | [
"Filtration and Separation",
"Process Chemistry and Technology"
] | |
European Cohorts of patients and schools to Advance Response to Epidemics (EuCARE): a cluster randomised interventional and observational study protocol to investigate the relationship between schools and SARS-CoV-2 infection | Abstract Background Contradictory results were reported on the role of school closure/reopening on the overall SARS-CoV-2 transmission rate, as well as on which kind and level of mitigation measures implemented in schools may be effective in limiting its diffusion. Some recent studies were reassuring, showing that opening did not increase the community spread, although teachers and families are worried about the high class density. On the other hand, distance learning was associated with a negative impact on learning, sociability and psychological health, especially in vulnerable children. As it becomes clear that the SARS-CoV-2 pandemic will last for a long time, there is a high need for studies and solutions to support safe schools opening based on scientific evidence of harms and benefits. The Lolli-Methode (LM) is a strategy for epidemiological surveillance and early intervention aiming at SARS-CoV-2 outbreaks’ reduction in schools, relying on polymerase chain reaction analysis of saliva samples. Methods In this cluster randomised trial protocol, we aim to determine whether the LM is useful to support schools opening and to reduce clusters and attack rates in schools, compared with the standard of care (SoC) surveillance by public health departments. This multicenter study will enrol 440 classes (around 8800 students, teachers and other personnel) from two countries, cluster randomised to LM or SoC. The samples from the pools will be collected and tested using PCR-based techniques. Test results will be combined with questionnaires filled in by children, parents, schoolteachers, and principals, concerning ongoing mitigation measures, their perceived psychological impact and other health and socio-economic information. An ancillary observational study will be carried out to study the prevalence of SARS-CoV-2 in schools, frequencies and size of clusters and attack rates, to compare the effectiveness of the different preventive measures adopted and to evaluate psychological issues in students and teachers in relation to the pandemic’s containment measures. Discussion By the end of this study, we will have defined and characterised the applicability of the LM for SARS-CoV-2 surveillance, as well as the impact of pandemic preventive measures on children and teachers. Trial registration International Standard Randomised Controlled Trial Number: NCT05396040, 27.05.2022. | [
"Infectious Diseases"
] | |
Indecent Exposure | [
"Cell Biology",
"Molecular Biology"
] | ||
Water mites (Hydrachnidia) of temporary ponds of Western Siberia: do the composition and the structure of acarofauna change over a long period of time? | Temporary ponds are specific freshwater habitats in which the characteristic fauna of aquatic organisms is formed. One of the large groups of invertebrates in temporary water bodies is water mites. In this work, water mites were studied in three different types of temporary ponds in the vicinity of the city of Tyumen, Western Siberia. The studies were carried out in two periods with a long time interval between them: in 2008–2010 and 2018–2019. In total, 33 species of water mites from 7 families were identified in the studied ponds. All ponds were dominated by vernal mite species typical for this type of water bodies. Also, they were characterized by similar seasonal dynamics of numbers. The species composition and the number of mites in different ponds varied, which is associated with different physicochemical parameters and the fauna of invertebrates, which served as food objects and hosts for the adults and larvae. Despite the small size and periodic drying of the ponds, the fauna of the mites inhabiting them has changed little over the long period of time that separates the studies. Only in one pond, which became permanent due to the rise of groundwater, significant changes in acarofauna were observed. Considering such constancy of the fauna of water mites of temporary ponds, they can be used as bioindicators of the ecological state of water bodies. | [
"Insect Science",
"Ecology",
"Ecology, Evolution, Behavior and Systematics"
] | |
Efficient Atomistic Simulation of Heterostructure Field-Effect Transistors | [
"Electrical and Electronic Engineering",
"Electronic, Optical and Magnetic Materials",
"Biotechnology"
] | ||
Optimizing measurement of the electrical anisotropy of muscle | [
"Physiology (medical)",
"Cellular and Molecular Neuroscience",
"Neurology (clinical)",
"Physiology"
] | ||
Study on friction properties of polydopamine modified graphene oxide as lubricant additive | [
"Organic Chemistry",
"Physical and Theoretical Chemistry",
"Atomic and Molecular Physics, and Optics"
] | ||
Efficient identity-based online/offline encryption and signcryption with short ciphertext | [
"Computer Networks and Communications",
"Safety, Risk, Reliability and Quality",
"Information Systems",
"Software"
] | ||
Law for the Nurse Manager | [
"Leadership and Management"
] | ||
Fruit traits of tree species in lower montane rainforest at Doi Suthep–Pui, northern Thailand | AbstractFruits are a major food resource for wildlifes and have evolved different traits which attract specific frugivores and facilitate seed dispersal. This study examines the quantity of the frequency of fruit tree species, distribution amongst fruit traits and estimates the potential availability of the fruit resource for frugivores in a 16-ha permanent forest plot at Doi Suthep–Pui, Thailand. The similarity amongst traits for fleshy fruited species was explored using Principal Component Analysis (PCA). Fleshy fruited species comprised 122 of 208 tree species >2 cm diameter at breast height (DBH) recorded in the permanent plot. Amongst fleshy fruited species, small fruits (length Litsea martabanica and Persea gamblei are the greatest density and represented the major PCA group; black, small-sized and thin husk indehiscent fruits. These fruiting trees scattered throughout the permanent plot and were of good regeneration status. Indicating fleshy fruit can be a food resource for frugivores especially small-sized fruit. Furthermore, large-fruited species such as Madhuca floribunda is low density but important to preserve for food resource of large frugivores. This finding is very important not only for forest protection policy but also for wildlife conservation as food resources. | [
"Ecology, Evolution, Behavior and Systematics"
] | |
English Undefiled | [
"Education"
] | ||
Hearts of Wisdom: American Women Caring for Kin, 1850-1940 | [
"History and Philosophy of Science",
"History"
] | ||
‘I like my accent but…’: EFL teachers’ evaluation of English accent varieties | [
"Linguistics and Language",
"Language and Linguistics",
"Education"
] | ||
Uniform helical fluid motion in a cone with a diaphragm | [
"Fluid Flow and Transfer Processes",
"Mechanical Engineering"
] | ||
Synthesis and antitumor activity of 5-deaza-5,6,7,8-tetrahydrofolic acid and its N10-substituted analogs | [
"Drug Discovery",
"Molecular Medicine"
] | ||
Tratamiento de trombocitopenia inmune primaria con eltrombopag en un paciente con síndrome coronario agudo reciente | [
"Cardiology and Cardiovascular Medicine"
] | ||
Long-term nonsurgical management of barrett's esophagus with high-grade dysplasia | [
"Gastroenterology",
"Hepatology"
] | ||
Placement | Journal of the American College of Emergency Physicians | [
"Critical Care and Intensive Care Medicine"
] | |
Suzanne Césaire: archéologie littéraire et artistique d’une mémoire empêchée. Par Anny-Dominique Curtius | [
"Literature and Literary Theory",
"Linguistics and Language",
"History",
"Language and Linguistics",
"Cultural Studies"
] | ||
Marks of Distinction | [
"Materials Chemistry"
] | ||
Inversion barriers by the MINDO [modified intermediate neglect of differential overlap] method | [
"Colloid and Surface Chemistry",
"Biochemistry",
"Catalysis"
] | ||
Interventional Radiology Strategies in the Treatment of Pseudomyxoma Peritonei | CardioVascular and Interventional Radiology | [
"Cardiology and Cardiovascular Medicine",
"Radiology, Nuclear Medicine and Imaging"
] | |
Structure and phase composition of Nb/Ti system subjected to compression plasma flow impact | [
"Materials Chemistry",
"Surfaces, Coatings and Films",
"Surfaces and Interfaces",
"Condensed Matter Physics"
] | ||
Coastal Cliffs: Report of a Symposium | The Geographical Journal | [
"Earth-Surface Processes",
"Geography, Planning and Development"
] | |
Study of Fe−Ti and Fe−TiN interfaces by conversion electron Mössbauer spectroscopy | [
"Physical and Theoretical Chemistry",
"Condensed Matter Physics",
"Nuclear and High Energy Physics",
"Atomic and Molecular Physics, and Optics"
] | ||
Enhanced Longevity by Ibuprofen, Conserved in Multiple Species, Occurs in Yeast through Inhibition of Tryptophan Import | [
"Cancer Research",
"Genetics (clinical)",
"Genetics",
"Molecular Biology",
"Ecology, Evolution, Behavior and Systematics"
] | ||
Finding harmony in the asymmetric aortic valve | [
"Cardiology and Cardiovascular Medicine",
"Surgery",
"Pulmonary and Respiratory Medicine"
] | ||
The Evidence Is In: Lifestyle Interventions Can Prevent Diabetes | Early epidemiological and clinical trials suggested that type 2 diabetes could be prevented or delayed by lifestyle modifications. The Finnish Diabetes Prevention Study and the Diabetes Prevention Programs provided conclusive evidence that type 2 diabetes could be prevented or delayed with modest lifestyle changes—5% to 7% loss of body weight and 150 min/week of physical activity. Both used intensive intervention strategies and continued support and follow-up to achieve study goals. Other smaller studies made similar observations. Various medications—metformin, acarbose, troglitazone and pioglitazone, orlistat, and rosiglitazone—and bariatric surgery have also been effective for the prevention or delay of diabetes. Nutrient factors studied include the contribution of a high dietary fat intake, especially saturated fat, to the development of diabetes and increased intake of fiber, whole grains, and alcohol to decreased risk. A review of the evidence led the American Diabetes Association to conclude that lifestyle interventions should be the first choice for prevention or delay of diabetes and that drug therapy should not be a substitute for lifestyle interventions—healthy and appropriate food choices and physical activity. | [
"Public Health, Environmental and Occupational Health",
"Health Policy",
"Medicine (miscellaneous)"
] | |
Mania-Like Symptoms Suggestive of Childhood-Onset Bipolar Disorder in Clinically Referred Children | [
"Psychiatry and Mental Health",
"Developmental and Educational Psychology"
] | ||
Is gradientless solid state calorimetry possible? | [
"Physical and Theoretical Chemistry",
"Condensed Matter Physics",
"Instrumentation"
] | ||
Inexpensive Japanese Beetle Traps | Journal of Economic Entomology | [
"Insect Science",
"Ecology"
] | |
„DIE ÄGYPTISCHE HELENA“ AN DER OPER | Österreichische Musikzeitschrift | [
"Music"
] | |
Unit Cell Dimension of Face-centered Cubic Chromium Hydride and Space Groups of Two Chromium Hydrides | [
"Colloid and Surface Chemistry",
"Biochemistry",
"Catalysis"
] | ||
Structural and pedagogic change in further and higher education: a case study approach | [
"Education"
] | ||
Olefin‐Palladiumchlorid‐Komplexe, IV. Zur Konstitution der π‐Allyl‐Palladiumchlorid‐Komplexe | [
"Inorganic Chemistry"
] | ||
Membership Changes | [
"Forestry"
] | ||
Structural and magnetic properties of the interstitial carbide-hydride NdScSiC0.5H0.2 | [
"Materials Chemistry",
"Metals and Alloys",
"Mechanical Engineering",
"Mechanics of Materials"
] | ||
Human leukocyte antigen class I and II alleles in non-Hodgkin lymphoma etiology | Abstract Genome-wide association and candidate gene studies implicate different genetic variants within the 6p21 chromosomal region with different non-Hodgkin lymphoma (NHL) subtypes. Complementing these efforts, we conducted human leukocyte antigen (HLA) class I and class II genotyping among 610 NHL cases and 555 controls of non-Hispanic white descent from a US multicenter study. Allele-disease associations were assessed by logistic regression for NHL and its subtypes. Statistically significant associations between HLA and NHL subtypes include HLA-DRB1*0101 for follicular lymphoma (odds ratio [OR] = 2.14, P | [
"Cell Biology",
"Hematology",
"Immunology",
"Biochemistry"
] | |
Catenary soil differentiation on opposite-facing slopes related to erosion-deposition and restricted leaching processes, northern Negev, Israel | [
"Earth-Surface Processes",
"Ecology",
"Ecology, Evolution, Behavior and Systematics"
] | ||
Abstract B19: Genome-wide integrated epigenomics identifies FZD-X as novel modulator for platinum sensitivity in high-grade serous ovarian cancer | Abstract The major hindrance for successful treatment of advanced stage ovarian cancer patients stems from platinum-based chemotherapy resistance. In cancer, the epigenetic alterations like DNA methylation, play a crucial role in regulation of genes related to response towards chemotherapies. Identifying these epigenetically regulated key genes, which modulate platinum response, may improve patient selection, response to therapy, and find novel targeted strategies to overcome platinum resistance. Here we applied integrated epigenomics approach to identify novel genes associated with high grade serous ovarian cancer platinum response. We performed next generation sequencing on methylation-enriched genomic DNA of ovarian cancer patient material from responders (≥18 months progression free survival, n=8) and non-responders (≤6 months progression free survival, n=10) to platinum chemoresponse. Expression data of same patients was also integrated to identify differentially methylated and expressed genes. These genes were validated further on external patients cohort using bisulfite-pyrosequencing and other publically available datasets. Furthermore, candidate genes were functionally tested on ovarian cancer cell lines panel using several in vitro assays. Based on integrated epigenomics analysis, we identified Frizzled receptor (FzdX) as an epigenetically regulated gene, significantly unmethylated (p<0.0005) and highly expressed (p<0.003) in non-responder group of ovarian cancer patients. Further, FzdX was successfully validated by bisulfite-pyrosequencing on independent external patient cohort (responder: n=21 and non-responder: n=31). Concordant hypermethylation and corresponding gene silencing of FzdX was observed in a large panel of ovarian cancer cell lines (n=11). Additionally, demethylating agents caused reduction in methylation and high expression of FzdX in ovarian cancer cell lines, confirming FzdX as an epigenetically regulated gene. Targeted genetic inhibition of FzdX using siRNAs in ovarian cancer cell lines caused significant sensitization towards cisplatin treatment in short and long-term survival assays. FzdX silencing made ovarian cancer cells more apoptosis prone as showed by apoptotic acridine orange staining and high expression of cleaved PARP and caspase 3. Furthermore, siRNAs mediated silencing of FzdX in ovarian cancer cell lines led to reduction in their migratory and invasion potential as compared to control counter parts in various functional assays. Conclusively, our integrative epigenomics analysis revealed FzdX as novel epigenetic modulator for platinum-sensitivity in ovarian cancer patients, which might be exploited for predictive and therapeutic approaches. This study has been granted by the Dutch Cancer Society, KWF (RUG 2010-4833). Citation Format: Tushar Tomar, Nicolette G. Alkema, Gert Jan Meersma, Tim De Meyer, Wim van Criekinge, Harry G. Klip, Ate GJ van der Zee, Steven de Jong, G. Bea A. Wisman. Genome-wide integrated epigenomics identifies FZD-X as novel modulator for platinum sensitivity in high-grade serous ovarian cancer. [abstract]. In: Proceedings of the AACR Special Conference on Chromatin and Epigenetics in Cancer; Sep 24-27, 2015; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2016;76(2 Suppl):Abstract nr B19. | [
"Cancer Research",
"Oncology"
] | |
Partial Superior Capsular Reconstruction to Augment Arthroscopic Repair of Massive Rotator Cuff Tears Using Autogenous Biceps Tendon: Effect on Retear Rate | Background: Massive rotator cuff tears have a high incidence of postoperative retear that can reach 90%. It is still unclear which intervention may reduce the incidence of retear and improve the functional and clinical outcomes. Purpose/Hypothesis: The purpose of this study was to investigate the clinical and structural outcomes at 2 years after repair of reparable massive rotator cuff tears with and without the use of partial superior capsular reconstruction (pSCR), using the autologous long head of the biceps tendon (LHBT) as a graft. It was hypothesized that augmentation with a pSCR would decrease retear rates. Study Design: Cohort study; Level of evidence, 3. Methods: The authors compared arthroscopic repair of massive posterosuperior rotator cuff tears with and without augmentation using the LHBT for pSCR between 2015 and 2017. After applying the selection criteria, 106 patients were included in the study and distributed into 2 groups of 50 and 56 patients. Patients in the first group (50 patients) underwent arthroscopic repair without use of the LHBT (AR group), and patients in the second group (56 patients) underwent arthroscopic repair with use of the LHBT for pSCR (AR-LHBT group). The structural outcome was evaluated by ultrasound at 2 years of follow-up. Function and pain were evaluated preoperatively and at the 2-year follow-up using the American Shoulder and Elbow Surgeons (ASES) score and visual analog scale (VAS). Pre- and postoperative active range of motion, including forward elevation, external rotation, and abduction, were also documented. Results: No significant differences were found between groups regarding the baseline characteristics. After 24 months, both groups showed significant improvement from preoperative ASES scores, VAS score, and active range of motion ( P Conclusion: Use of the LHBT for pSCR to augment massive rotator cuff tears resulted in markedly lower retear rates and modestly improved pain and function outcomes compared with repair alone. | The American Journal of Sports Medicine | [
"Physical Therapy, Sports Therapy and Rehabilitation",
"Orthopedics and Sports Medicine"
] |
Editorial Board | [
"Pharmacology (medical)",
"Psychiatry and Mental Health",
"Pharmacology",
"Toxicology"
] | ||
Libras Humor: Playing with the Internal Structure of Signs | Sign Language Studies | [
"Linguistics and Language",
"Language and Linguistics"
] | |
Pulsations of microwave emission and flare plasma diagnostics | Astronomy Letters | [
"Space and Planetary Science",
"Astronomy and Astrophysics"
] | |
Comparison of Four Serological Tests To Determine the CagA or VacA Status of Helicobacter pylori Strains | ABSTRACT We compared four tests for antibodies to CagA or VacA, HelicoBlot 2.0, RIDA Blot Helicobacter, CHIRON RIBA H. pylori SIA, and an enzyme-linked immunosorbent assay using recombinant CagA. Immunoblot assays were accurate for determining Helicobacter pylori status but poor for determining CagA or VacA status (accuracy, 66 to 80% for CagA status and 34 to 67% for VacA status). None can be recommended for determining CagA or VacA status. | [
"Microbiology (medical)"
] | |
The chill chain “from carcass to consumer” | [
"Food Science"
] | ||
Prognostic evaluation by oxygenation with positive end-expiratory pressure in acute exacerbation of idiopathic pulmonary fibrosis: A retrospective cohort study | The Clinical Respiratory Journal | [
"Genetics (clinical)",
"Pulmonary and Respiratory Medicine",
"Immunology and Allergy"
] | |
The lower reaches of the Nemunas River at the end of the Last (Weichselian) Glacial and beginning of the Holocene | [
"Geology"
] | ||
The construction of discrete orthogonal coordinates | [
"Computer Science Applications",
"Physics and Astronomy (miscellaneous)",
"Applied Mathematics",
"Computational Mathematics",
"Modeling and Simulation",
"Numerical Analysis"
] | ||
An intermolecular potential for (NH3)2 | [
"Physical and Theoretical Chemistry"
] | ||
Pathological observations of intrahepatic peribiliary glands in 1,000 consecutive autopsy livers. II. A possible source of cholangiocarcinoma | [
"Hepatology"
] | ||
Catamenial pneumothorax recurrence due to endometriosis | [
"Pulmonary and Respiratory Medicine"
] | ||
Absorción peritoneal de líquido de irrigación vesical | [
"Anesthesiology and Pain Medicine",
"Critical Care and Intensive Care Medicine"
] | ||
Tentative guidelines for studying the behaviour of p,p'-DDT under field and laboratory conditions | Journal of Environmental Science and Health, Part B | [
"Pollution",
"Food Science"
] | |
British Food Journal Volume 26 Issue 1 1924 | At a meeting of the Hull Corporation Health Committee, on November 22nd, the Town Clerk referred to the decision in the recent case of milk, alleged to have contained dirt. Originally the justices dismissed the summons on a legal point. The Corporation, prosecuting, asked for a case to be stated in the High Court, and the latter decided in the Corporation's favour, and sent the case back to the Hull magistrates to be heard on its merits. The evidence of the prosecution was that the milk contained 3·9 parts of dirt per 100,000 parts of milk, the far greater part of the sediment present consisting of manure. In previous cases prosecutions were secured where the dirt was slightly less, but this summons was dismissed on the ground that there was no standard laid down by law as to what amount of dirt might be permitted. If this was a reason for dismissal, then milk might be half dirt. That was absurd. The question was “What was the Corporation going to do?” He suggested that they should go on exactly as they were doing, take the cases, and place the responsibility on the justices. Perhaps if they went on a little longer they would get some idea at to what the Bench considered was such a state of contamination as to justify the local authority in taking action. | [
"Food Science",
"Business, Management and Accounting (miscellaneous)"
] | |
A Model of Neutralization Techniques | Deviant Behavior | [
"Law",
"Sociology and Political Science",
"Clinical Psychology",
"Social Psychology"
] | |
Formation and roles of hydrogen peroxide during soil remediation by direct multi-channel pulsed corona discharge in soil | [
"Filtration and Separation",
"Analytical Chemistry"
] | ||
The influence of electric-field bending on the nonlinearity of capacitive sensors | IEEE Transactions on Instrumentation and Measurement | [
"Electrical and Electronic Engineering",
"Instrumentation"
] | |
p-Methoxyphenacyl esters as photodeblockable protecting groups for phosphates | Journal of the Chemical Society, Chemical Communications | [
"Molecular Medicine"
] | |
Reactions of Diethyl Dibromomalonate and Ethyl 2,2-Dichloroacetoacetate with Water and Carbonyl Compounds (Aldehydes and Ketones) in the Presence of Pentacarbonyliron | [
"Organic Chemistry"
] | ||
Defying death: showing Bcl-2 the way home | [
"Cell Biology"
] | ||
Characterization of γS-Crystallin Isoforms from Lip Shark (Chiloscyllium colax): Evolutionary Comparison between γS and β/γ Crystallins | [
"Cell Biology",
"Molecular Biology",
"Biochemistry",
"Biophysics"
] | ||
The Arabidopsis SUMO E3 Ligase AtMMS21 Dissociates the E2Fa/DPa Complex in Cell Cycle Regulation | AbstractDevelopment requires the proper execution and regulation of the cell cycle via precise, conserved mechanisms. Critically, the E2F/DP complex controls the expression of essential genes during cell cycle transitions. Here, we discovered the molecular function of the Arabidopsis thaliana SUMO E3 ligase METHYL METHANESULFONATE SENSITIVITY GENE21 (AtMMS21) in regulating the cell cycle via the E2Fa/DPa pathway. DPa was identified as an AtMMS21-interacting protein and AtMMS21 competes with E2Fa for interaction with DPa. Moreover, DPa is a substrate for SUMOylation mediated by AtMMS21, and this SUMOylation enhances the dissociation of the E2Fa/DPa complex. AtMMS21 also affects the subcellular localization of E2Fa/DPa. The E2Fa/DPa target genes are upregulated in the root of mms21-1 and mms21-1 mutants showed increased endoreplication. Overexpression of DPa affected the root development of mms21-1, and overexpression of AtMMS21 completely recovered the abnormal phenotypes of 35S:E2Fa-DPa plants. Our results suggest that AtMMS21 dissociates the E2Fa/DPa complex via competition and SUMOylation in the regulation of plant cell cycle. | [
"Cell Biology",
"Plant Science"
] | |
The Muller’s Ratchet and Aging | Trends in Genetics | [
"Genetics"
] | |
Self-crosslinking hyaluronic acid–carboxymethylcellulose hydrogel enhances multilayered 3D-printed construct shape integrity and mechanical stability for soft tissue engineering | Abstract One of the primary challenges in extrusion-based 3D bioprinting is the ability to print self-supported multilayered constructs with biocompatible hydrogels. The bioinks should have sufficient post-printing mechanical stability for soft tissue and organ regeneration. Here, we report on the synthesis, characterization and 3D printability of hyaluronic acid (HA)–carboxymethylcellulose (CMC) hydrogels cross-linked through N-acyl-hydrazone bonding. The hydrogel’s hydrolytic stability was acquired by the effects of both the prevention of the oxidation of the six-membered rings of HA, and the stabilization of acyl-hydrazone bonds. The shear-thinning and self-healing properties of the hydrogel allowed us to print different 3D constructs (lattice, cubic and tube) of up to 50 layers with superior precision and high post-printing stability without support materials or post-processing depending on their compositions (H7:C3, H5:C5 and H3:C7). Morphological analyses of different zones of the 3D-printed constructs were undertaken for verification of the interconnection of pores. Texture profile analysis (TPA) (hardness (strength), elastic recovery, etc) and cyclic compression studies of the 3D-printed constructs demonstrated exceptional elastic properties and fast recovery after 50% strain, respectively, which have been attributed to the addition of CMC into HA. A model drug quercetin was released in a sustained manner from hydrogels and 3D constructs. In vitro cytotoxicity studies confirmed the excellent cyto-compatibility of these gels. In vivo mice studies prove that these biocompatible hydrogels enhance angiogenesis. The results indicate that controlling the key properties (e.g. self-crosslinking capacity, composition) can lead to the generation of multilayered constructs from 3D-bioprintable HA-CMC hydrogels capable of being leveraged for soft tissue engineering applications. | [
"Biomedical Engineering",
"Biomaterials",
"Biochemistry",
"Bioengineering",
"Biotechnology"
] | |
Minocycline can delay the development of morphine tolerance, but cannot reverse existing tolerance in the maintenance period of neuropathic pain in rats | Clinical and Experimental Pharmacology and Physiology | [
"Physiology (medical)",
"Pharmacology",
"Physiology"
] | |
The accelerating effect of a small cationic quaternary ammonium compound and the adsorption kinetics in the dyeing of silk with reactive dyes | [
"Materials Science (miscellaneous)",
"Chemistry (miscellaneous)"
] | ||
The Establishment of Telomerase-immortalized Tangier Disease Cell Lines Indicates the Existence of an Apolipoprotein A-I-inducible but ABCA1-independent Cholesterol Efflux Pathway | Journal of Biological Chemistry | [
"Cell Biology",
"Molecular Biology",
"Biochemistry"
] | |
Transition from open partial nephrectomy directly to robotic surgery: experience of a single surgeon to achieve “TRIFECTA” | International braz j urol | [
"Urology"
] | |
Legal update | [
"Management Science and Operations Research"
] | ||
On the remainder of truncated asymptotic series | [
"Computer Science Applications",
"Physics and Astronomy (miscellaneous)",
"Applied Mathematics",
"Computational Mathematics",
"Modeling and Simulation",
"Numerical Analysis"
] | ||
Prognostic factors for stage III epithelial ovarian cancer treated with intraperitoneal chemotherapy: A Gynecologic Oncology Group study | [
"Obstetrics and Gynecology",
"Oncology"
] | ||
Assessment of the stability of sheep sausages with the addition of different concentrations of Origanum vulgare extract during storage | [
"Food Science"
] | ||
Systemic Histiocytosis* | [
"Ophthalmology"
] | ||
Bridging Coordination of Vinylarenes to Pd3 - or Pd4 Cluster Sites | [
"Catalysis",
"Organic Chemistry"
] | ||
Acquisition and performance as a function of uncertainty and structure in serial tracking tasks | Acta Psychologica | [
"Arts and Humanities (miscellaneous)",
"Developmental and Educational Psychology",
"Experimental and Cognitive Psychology"
] | |
Experimental investigation of the seismic performance of trapeze supports of the suspended ducts and pipes | [
"Safety, Risk, Reliability and Quality",
"Building and Construction",
"Architecture",
"Civil and Structural Engineering"
] | ||
FELTARBEJDE OM ETNISK IDENTITET: Et canadisk indiansk samfund i 1990’eme | Niels Winther Braroe: Fieldwork on Ethnic Identity: A Canadian Indian Community in the 1990’s This article describes some obstacles to fieldwork in a Plains Cree Indian com-munity. The research is a continuation of study begun in the 1960’s, after an absence of twenty-five years. Two areas of “trouble” are discussed. The first has to do with the effects of a book about the community published by the author; the second set of difficulties results from newly emergent factional divisions on the reserve. Both of these are relevant to the author’s interest in changing expressions of ethnic identity of the band, and political and economic changes associated with a new Indian cultural self-image. The author describes some approaches taken to negotiate these obstacles. | [
"Anthropology"
] | |
Synthesis of 6-methyl-7-hydroxy-8-ribityllumazine and its identification with a blue-violet fluorescent substance from Ashbya gossypii | [
"Molecular Biology",
"Biochemistry",
"Biophysics"
] | ||
Reducing hip fracture risk with risedronate in elderly women with established osteoporosis | [
"Geriatrics and Gerontology"
] | ||
Effectiveness of Monovalent and Pentavalent Rotavirus Vaccine | OBJECTIVE: Previous US evaluations have not assessed monovalent rotavirus vaccine (RV1, a G1P[8] human rotavirus strain) effectiveness, because of its later introduction (2008). Using case-control methodology, we measured the vaccine effectiveness (VE) of the 2-dose RV1 and 3-dose pentavalent vaccine (RV5) series against rotavirus disease resulting in hospital emergency department or inpatient care. METHODS: Children were eligible for enrollment if they presented to 1 of 5 hospitals (3 in Georgia, 2 in Connecticut) with diarrhea of ≤10 days’ duration during January through June 2010 or 2011, and were born after RV1 introduction. Stools were collected; immunization records were obtained from providers and state electronic immunization information system (IIS). Case-subjects (children testing rotavirus antigen-positive) were compared with 2 control groups: children testing rotavirus negative and children selected from IIS. RESULTS: Overall, 165 rotavirus-case subjects and 428 rotavirus-negative controls were enrolled. Using the rotavirus-negative controls, RV1 VE was 91% (95% confidence interval [CI] 80 to 95) and RV5 VE was 92% (CI 75 to 97) among children aged ≥8 months. The RV1 VE against G2P[4] disease was high (94%, CI 78 to 98), as was that against G1P[8] disease (89%, CI 70 to 96). RV1 effectiveness was sustained among children aged 12 through 23 months (VE 91%; CI 75 to 96). VE point estimates using IIS controls were similar to those using rotavirus-negative controls. CONCLUSIONS: RV1 and RV5 were both highly effective against severe rotavirus disease. RV1 conferred sustained protection during the first 2 years of life and demonstrated high effectiveness against G2P[4] (heterotypic) disease. | [
"Pediatrics, Perinatology and Child Health"
] | |
Hong Kong's Growth Synchronisation with China and the U.S.: A Trend and Cycle Analysis | SSRN Electronic Journal | [
"Industrial and Manufacturing Engineering",
"Polymers and Plastics",
"History",
"Business and International Management"
] | |
Quantitation of Specific Parameters of Motility in Large Numbers of Human Sperm by Digital Image Processing1 | [
"Cell Biology",
"Reproductive Medicine"
] | ||
Temperature structure functions for air flow over moderately heated ground | [
"Condensed Matter Physics",
"Fluid Flow and Transfer Processes",
"Mechanics of Materials",
"Computational Mechanics",
"Mechanical Engineering"
] | ||
Linear optical signal processing with optical filters: a tutorial | [
"Electrical and Electronic Engineering",
"Electronic, Optical and Magnetic Materials"
] | ||
3 Wnt/β-catenin signalling is a potential therapeutic target for castrate-resistant prostate cancer | [
"Urology"
] | ||
Refining the link between psychopathy, antisocial behavior, and empathy: A meta-analytical approach across different conceptual frameworks | [
"Psychiatry and Mental Health",
"Clinical Psychology"
] | ||
Theory of global cooling | [
"Energy Engineering and Power Technology",
"Development",
"Renewable Energy, Sustainability and the Environment"
] | ||
The In vitro Cultivation of Oesophagostomum radiatum, the Nodular Worm of Cattle. II. The Use of This Technique to Study Immune Responses of Host Tissue Extracts against the Developing Nematode | [
"Ecology, Evolution, Behavior and Systematics",
"Parasitology"
] | ||
Fetal congenital complete heart block: prophylaxis with intravenous gammaglobulin and treatment with dexamethasone | The Australian and New Zealand Journal of Obstetrics and Gynaecology | [
"Obstetrics and Gynecology"
] |
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