Title stringlengths 0 905 | Abstract stringlengths 0 11.3k | Container_Title stringlengths 0 126 | Subject listlengths 1 13 |
|---|---|---|---|
Intraoperative Heparin Flushes and Subsequent Acute Heparin-induced Thrombocytopenia | [
"Anesthesiology and Pain Medicine"
] | ||
PROGRAMAS DE EDUCACIÓN SEXUAL EN PANAMÁ | [
"Health Policy",
"Health (social science)"
] | ||
Moving from Silos to Systems in Black Women’s Health Research | Abstract This special issue of Meridians offers a unique opportunity to reflect on the complexity of black women’s racialized and gendered health landscapes in light of relevant social and political contexts and conventions about: a) what constitutes research excellence, and b) how and by whom credible research is created. Throughout my forty-plus years of academic life, I have been repeatedly and sometimes painfully reminded of the importance of ongoing critical reflection on what it will take for black health researchers to generate evidence that will have major impacts on the health of black communities and individuals. US black women’s reproductive outcomes, health risk factors, disease occurrence, and survival after disease onset reflect multiple disadvantages when compared with US white women and, in some cases, with black men. These disadvantages can be understood as legacies of racially-biased and discriminatory US social and economic policies, practices, and attitudes dating back to black enslavement. Underlying causes of pervasive and persistent health disparities affecting the US black population are generally not acknowledged or are underestimated, including within academic circles. Black women’s health researchers, therefore face ongoing challenges of studying disparities in ways that take these underlying causes into account, while recognizing that such research may be met with resistance in various forms. Furthermore, research that addresses the diverse, dynamic, and intersectional causes of black women’s health problems will require multisectoral, multilevel, and interdisciplinary collaborations that extend beyond the boundaries and discipline-specific paradigms of the academic silos that typically control academic reward systems. I envision a future black women’s health research agenda that emanates from such a systems paradigm. The agenda would frame black women’s health and well-being as emerging from complex interactions among several causal factors acting at multiple levels and shifting over time. I believe that black women academics and those who link arms with us to address black women’s health issues have the capacity to succeed in generating major and long-lasting improvements in black women’s health, but only if we radically shift our approach to be systems-oriented. Current approaches may produce isolated successes, but these can easily be attenuated by the larger, unfavorable systems in which they occur. This vision is timely considering current US and global attention to social determinants of health and to achieving overall health equity. There are great opportunities, individually and (especially) collectively, to build on learnings from past decades and leverage today’s research tools to impact upon current and emerging black women’s health issues. | [
"Social Sciences (miscellaneous)",
"Anthropology",
"Gender Studies"
] | |
Economic Security in the United States. | [
"Management of Technology and Innovation",
"Organizational Behavior and Human Resource Management",
"Strategy and Management"
] | ||
Chronische Eisenmangelanämie aufgrund intestinaler Telangiektasien bei einer Jugendlichen mit kongenitaler Asplenie | [
"Gastroenterology"
] | ||
Characterization and cloning of chitin deacetylases from Rhizopus circinans | [
"Biotechnology"
] | ||
Mitochondrial DNA Methylation and the Development of Diabetic Retinopathy | Free Radical Biology and Medicine | [
"Physiology (medical)",
"Biochemistry"
] | |
Maritime Scenography and the Spectacle of Cruising | [
"Visual Arts and Performing Arts"
] | ||
P1‐312: BRAINS FOR DEMENTIA RESEARCH: CONCORDANCE OF CLINICAL AND NEUROPATHOLOGICAL DIAGNOSES IN DECEASED PARTICIPANTS | [
"Psychiatry and Mental Health",
"Cellular and Molecular Neuroscience",
"Geriatrics and Gerontology",
"Neurology (clinical)",
"Developmental Neuroscience",
"Health Policy",
"Epidemiology"
] | ||
Canzoniere | [
"Literature and Literary Theory"
] | ||
An accurate pair potential function for diatomic systems | [
"Physical and Theoretical Chemistry"
] | ||
Nosocomial rotavirus infections in adult renal transplant recipients | [
"Infectious Diseases",
"Microbiology (medical)"
] | ||
Editorial. The (Un) Scientific Method | [
"Analytical Chemistry"
] | ||
Priority Assistance to Laboratories | [
"Analytical Chemistry"
] | ||
Burial dolomitization and dedolomitization of the late Cambrian Wagok Formation, Yeongweol, Korea | [
"Geochemistry and Petrology"
] | ||
EINGEGANGENE BÜCHER | ZAMM - Zeitschrift für Angewandte Mathematik und Mechanik | [
"Applied Mathematics",
"Computational Mechanics"
] | |
U.S | [
"Critical Care and Intensive Care Medicine",
"Surgery"
] | ||
RETROPERITONEAL NEUROFIBROSARCOMA IN A PATIENT WITH NEUROFIBROMATOSIS 2: A CASE REPORT AND REVIEW OF THE LITERATURE | [
"Pathology and Forensic Medicine",
"Pediatrics, Perinatology and Child Health"
] | ||
Asymptotic analysis of compound liquid jets at low Reynolds numbers | Applied Mathematics and Computation | [
"Applied Mathematics",
"Computational Mathematics"
] | |
Andrew Salkey Wins Poetry Award | [
"Sociology and Political Science",
"Arts and Humanities (miscellaneous)",
"Cultural Studies"
] | ||
Recurrent versus diffusive dynamics for a kicked quantum system | [
"Mathematical Physics",
"Statistical and Nonlinear Physics"
] | ||
Thompson’s conjecture for some finite simple groups with connected prime graph | [
"Logic",
"Analysis"
] | ||
Human ATP-Binding Cassette transporters ABCB1 and ABCG2 confer resistance to CUDC-101, a multi-acting inhibitor of histone deacetylase, epidermal growth factor receptor and human epidermal growth factor receptor 2 | [
"Pharmacology",
"Biochemistry"
] | ||
Experimental Study of One-Shot Vascular Anastomostic Device for Proximal Vein Graft Anastomoses | [
"Cardiology and Cardiovascular Medicine",
"Pulmonary and Respiratory Medicine",
"Surgery"
] | ||
Unregelmässiges Verhalten von Fliessbettsystemen bei rheologischen Messungen | [
"Applied Mathematics",
"Industrial and Manufacturing Engineering"
] | ||
Differential decomposition of arbuscular mycorrhizal fungal hyphae and glomalin | [
"Soil Science",
"Microbiology"
] | ||
A Clinicopathologic Correlative Study of Noncontact Transscleral Nd:YAG Cyclophotocoagulation | [
"Ophthalmology"
] | ||
Effects of rehydration on physiological and transcriptional responses of a water-stressed rhizobium | Journal of Microbiology | [
"Applied Microbiology and Biotechnology",
"Microbiology"
] | |
A New Method to Harvest Ramus Bone Using the Erbium, Chromium:Yttrium-Scandium-Gallium-Garnet Laser | [
"Otorhinolaryngology",
"Oral Surgery",
"Surgery"
] | ||
EDB | [
"Electrochemistry"
] | ||
After 9/11: US Policy in Northeast Asia | Asia-Pacific Review | [
"Political Science and International Relations",
"Economics and Econometrics",
"History"
] | |
Time trend of asthma prevalence among school children in Taiwan: ISAAC phase I and III surveys | [
"Immunology",
"Immunology and Allergy",
"Pediatrics, Perinatology and Child Health"
] | ||
Introductory Statistical Inference by N. Mukhopadhyay | [
"Statistics, Probability and Uncertainty",
"Economics and Econometrics",
"Social Sciences (miscellaneous)",
"Statistics and Probability"
] | ||
Effect of Acute Δ9-Tetrahydrocannabinol Treatment on Serum Luteinizing Hormone and Prolactin Levels in Adult Female Rats | [
"Obstetrics and Gynecology",
"Reproductive Medicine"
] | ||
Purification and properties of a self-associating, 50-kDa copper-binding protein from brindled mouse livers. | [
"Cell Biology",
"Molecular Biology",
"Biochemistry"
] | ||
La patrulla multiétnica en la Segunda Guerra Mundial: nuevas perspectivas sobre el cine de combate | Se repasa aquí la evolución del cine de la Segunda Guerra Mundial que tiene como centro la peripecia de un pequeño grupo de soldados –patrulla o escuadrón– sometido a la tensión del combate y que presentan orígenes culturales diversos. así mismo se revisarán aportaciones como las de Quentin Tarantino (Malditos bastardos, 2009) o David ayer (Corazones de acero, 2014) en las que la violencia y el deseo de venganza son síntomas del desencanto y el pesimismo ante los conflictos bélicos actuales. | Revista de Filología Románica | [
"Literature and Literary Theory",
"Linguistics and Language",
"Language and Linguistics"
] |
Evaluation of Heterocyclic Carboxamides as Potential Efflux Pump Inhibitors in Pseudomonas aeruginosa | The ability to rescue the activity of antimicrobials that are no longer effective against bacterial pathogens such as Pseudomonas aeruginosa is an attractive strategy to combat antimicrobial drug resistance. Herein, novel efflux pump inhibitors (EPIs) demonstrating strong potentiation in combination with levofloxacin against wild-type P. aeruginosa ATCC 27853 are presented. A structure activity relationship of aryl substituted heterocyclic carboxamides containing a pentane diamine side chain is described. Out of several classes of fused heterocyclic carboxamides, aryl indole carboxamide compound 6j (TXA01182) at 6.25 µg/mL showed 8-fold potentiation of levofloxacin. TXA01182 was found to have equally synergistic activities with other antimicrobial classes (monobactam, fluoroquinolones, sulfonamide and tetracyclines) against P. aeruginosa. Several biophysical and genetic studies rule out membrane disruption and support efflux inhibition as the mechanism of action (MOA) of TXA01182. TXA01182 was determined to lower the frequency of resistance (FoR) of the partner antimicrobials and enhance the killing kinetics of levofloxacin. Furthermore, TXA01182 demonstrated a synergistic effect with levofloxacin against several multidrug resistant P. aeruginosa clinical isolates. | [
"Pharmacology (medical)",
"Infectious Diseases",
"Microbiology (medical)",
"Biochemistry",
"Microbiology"
] | |
Rapid diagnosis of amoebic liver abscess using recombinant Entamoeba histolytica pyruvate phosphate dikinase | [
"Infectious Diseases",
"Microbiology (medical)"
] | ||
The potential role of biological treatment of chronic rhinosinusitis with nasal polyps: a nationwide cohort study | Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) can be a challenge to treat despite appropriate pharmacological therapy and endoscopic sinus surgery. With the introduction of biological treatment, costs will increase. In this study, we determine the number of patients with CRSwNP treated with endoscopic sinus surgery and revision surgery and thereby fulfil the main criterion for treatment with biologics in the newest European guidelines. Furthermore, we estimate a potential number of recipients of biologics nationwide. Methods: All adult patients registered in the Danish National Patient Registry as having undergone first endoscopic sinus surgery for CRSwNP from 2012–2018 were included. The number of operations, surgery dates, and comorbidities were extracted. The Kaplan-Meier method was used to calculate the revision rate over time. Revision surgery was used as a surrogate to determine the pool of potential recipients of biologics, as these would fulfil the eligibility criteria and ensure the necessary cost-effectiveness. Results: A total of 4667 operated patients with CRSwNP were included out of a population of 4.7 million adults (incidence 14/100,000 person-years). Approximately 18% (120 per year) was estimated to have revision surgery within seven years. The median time to revision surgery was 22 months. Of all analysed patients, 21% had registered asthma and/or allergic rhinitis, while these diseases were registered in 34% of patients treated with revision surgery. Conclusion: In Denmark, an average of 120 operated patients annually will have revision surgery within seven years and may benefit from treatment with biologics as an alternative option to revision surgery. | [
"Otorhinolaryngology"
] | |
The NAD-dependent protein deacetylase Sirt1 regulates POMC transcription and ACTH synthesis | [
"Endocrinology",
"Endocrinology, Diabetes and Metabolism",
"Internal Medicine"
] | ||
Investigating the Usability of Universities’ Websites: Upgrading Visualization Preference and System Performance | The usefulness of a web site is based on the prospect of a satisfactory website user. In improving the usefulness of a university’s website, it is essential to present precise data and disseminate prompt information to students. This paper was conducted to analyse and recommend a better process for the information display (content and work processes) of university websites development. Questionnaires were distributed and feedbacks were received from 350 respondents. The aim of the study was to evaluate the effectiveness of the process of (content and processes) of the university websites based on five main aspects: i) Content and Organization Structure, ii) Linkages and Navigation, iii) Language, iv) Education Content and v) Option and Performance. Analysis showed that the percentage of question items has a positive tendency in perception regarding improvements need to enhance the intensity of the university website portal, especially in terms of links, content organization and live help desk requirements that can directly provide an easier means of that can providing information and accelerating up the operation of receiving data. In summary, this study also outlines the proposal for academic websites display to increase the serviceability of the site to users. | International Journal of Interactive Mobile Technologies (iJIM) | [
"Computer Networks and Communications",
"Computer Science Applications"
] |
Book Review: Petrarch the First Modern Scholar and Man of Letters | Journal of Education | [
"Education"
] | |
Peter the Chanter, Innocent III and Theological Views on Collective Guilt and Punishment | Innocent III regularised ecclesiastical usage of several penalties which punished the innocent along with the guilty, notably the interdict. His actions need to be understood in their intellectual as well as political context. It has long been thought that Peter the Chanter taught the future pope when he studied theology at Paris. This article presents evidence of the Chanter's radical influence on Innocent's attitude to collective guilt and punishment and compares their views with canonistic doctrine. | [
"Religious Studies",
"History"
] | |
Genome-Wide Association Screening Determines Peripheral Players in Male Fertility Maintenance | Deciphering the functional relationships of genes resulting from genome-wide screens for polymorphisms that are associated with phenotypic variations can be challenging. However, given the common association with certain phenotypes, a functional link should exist. We have tested this prediction in newly sequenced exomes of altogether 100 men representing different states of fertility. Fertile subjects presented with normal semen parameters and had naturally fathered offspring. In contrast, infertile probands were involuntarily childless and had reduced sperm quantity and quality. Genome-wide association study (GWAS) linked twelve non-synonymous single-nucleotide polymorphisms (SNPs) to fertility variation between both cohorts. The SNPs localized to nine genes for which previous evidence is in line with a role in male fertility maintenance: ANAPC1, CES1, FAM131C, HLA-DRB1, KMT2C, NOMO1, SAA1, SRGAP2, and SUSD2. Most of the SNPs residing in these genes imply amino acid exchanges that should only moderately affect protein functionality. In addition, proteins encoded by genes from present GWAS occupied peripheral positions in a protein–protein interaction network, the backbone of which consisted of genes listed in the Online Mendelian Inheritance in Man (OMIM) database for their implication in male infertility. Suggestive of an indirect impact on male fertility, the genes focused were indeed linked to each other, albeit mediated by other interactants. Thus, the chances of identifying a central player in male infertility by GWAS could be limited in general. Furthermore, the SNPs determined and the genes containing these might prove to have potential as biomarkers in the diagnosis of male fertility. | [
"Inorganic Chemistry",
"Organic Chemistry",
"Physical and Theoretical Chemistry",
"Computer Science Applications",
"Spectroscopy",
"Molecular Biology",
"Catalysis"
] | |
On Fennoscandian polypores 9. Gelatoporia n. gen. and Tyromyces canadensis, plus notes on Skeletocutis and Antrodia | [
"Infectious Diseases",
"Plant Science",
"Microbiology"
] | ||
An outcome measure for patients with cervical myelopathy: Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ): Part 1 | [
"Orthopedics and Sports Medicine",
"Surgery"
] | ||
Indium zinc oxide films deposited on PET by LF magnetron sputtering | [
"Surfaces, Coatings and Films",
"Acoustics and Ultrasonics",
"Condensed Matter Physics",
"Electronic, Optical and Magnetic Materials"
] | ||
Registration of Occupational Diseases in Costa Rica | [
"Epidemiology"
] | ||
Intergroup Trial Fails to Demonstrate a Benefit with the Addition of Irinotecan to Bolus 5-Fluorouracil/Leucovorin in Stage III Colon Cancer | [
"Gastroenterology",
"Oncology"
] | ||
Generation of catalytic protein particles in Escherichia coli cells using the cellulose-binding domain from Cellulomonas fimi as a fusion partner | [
"Biomedical Engineering",
"Applied Microbiology and Biotechnology",
"Bioengineering",
"Biotechnology"
] | ||
A low-energy-spread rf accelerator for a far-infrared free electron laser | [
"Instrumentation",
"Nuclear and High Energy Physics"
] | ||
Evolutionary relationships of the Tehuelche scallop Aequipecten tehuelchus (Bivalvia: Pectinidae) from the south-western Atlantic Ocean | This study addresses aspects of the phylogenetic relationships of the commercial Tehuelche scallop, Aequipecten tehuelchus s.l. (Bivalvia: Pectinidae), from southern South America using molecular techniques. The Tehuelche scallop presents two different putative subspecies, A. t. tehuelchus and A. t. madrynensis, and a potentially related sympatric species, Flexopecten felipponei. The Tehuelche scallop is a very important component of ecosystems and is the target of artisanal fisheries in the northern Patagonian gulfs of Argentina. Despite its importance, the systematic relationships of these taxa have not been fully addressed. The main goal of this study is to place the Tehuelche scallop within a partial phylogenetic framework of the family Pectinidae. Scallops were sampled at 10 localities distributed along the south-western Atlantic Ocean. Phylogenetic reconstructions were carried out from two mitochondrial (12S rRNA and 16S rRNA) and two nuclear markers (28S rRNA and H3) using Bayesian, maximum likelihood and maximum parsimony analyses. Our phylogenetic analysis indicates that the two putative subspecies of the Tehuelche scallop together with F. felipponei form a monophyletic clade, without differentiating at the specific level. Observed differences would be the result of phenotypic plasticity, probably caused by environmental factors. However, further analysis using genes with faster evolution rate are needed to corroborate it. Our phylogenetic analysis resolved to Aequipecten as polyphyletic. The Tehuelche scallop has a basal position within the Argopecten group and we recommend that it should be transferred to this genus. The relationship between the hypotheses about the origin of the Tehuelche scallop implicit in the literature and our results are discussed. | Journal of the Marine Biological Association of the United Kingdom | [
"Aquatic Science"
] |
Resminostat in patients with relapsed or refractory Hodgkin lymphoma: results of the phase II SAPHIRE study | Leukemia & Lymphoma | [
"Cancer Research",
"Oncology",
"Hematology"
] | |
The status and distribution of three species of Sternula terns on the eastern coast of Africa and in the western Indian Ocean, with two species new for Mozambique | [
"Animal Science and Zoology",
"Ecology, Evolution, Behavior and Systematics"
] | ||
Neurophysiology of migraine | The Journal of Headache and Pain | [
"Anesthesiology and Pain Medicine",
"Neurology (clinical)"
] | |
The influence of test method, conductor profile and substrate anisotropy on the permittivity values required for accurate modeling of high frequency planar circuits | PurposeThe purpose of this paper is to help high frequency circuit designers understand how to choose the best permittivity value for a laminate material for accurate modeling.Design/methodology/approachIn this paper, experimental measurements of the performance of simple circuits are compared to various mathematical and software models.FindingsHigher permittivity values were obtained using samples with bonded copper foil compared to samples etched free of foil. These higher values yielded better agreement between measured and modelled performance using current automated design software. High profile foil on thin laminates was found to increase the surface impedance of the conductor and change the propagation constant and apparent permittivity of the laminate by 15 percent or more. It was also demonstrated that, under some circumstances, the anisotropy of the substrate could result in differences in measured and modelled performance.Research limitations/implicationsOnly a limited number of circuit laminate materials were closely examined. Future work should include a wider variety of laminates.Originality/valueThe paper details the magnitude of the effects of test method, conductor profile and substrate anisotropy on the values of a material's permittivity best suited for circuit design purposes. | [
"Electrical and Electronic Engineering",
"Industrial and Manufacturing Engineering"
] | |
Electrodeposition of Bright Al-Zr Alloy Coatings from Dimethylsulfone-Based Baths | Journal of The Electrochemical Society | [
"Materials Chemistry",
"Electrochemistry",
"Surfaces, Coatings and Films",
"Condensed Matter Physics",
"Renewable Energy, Sustainability and the Environment",
"Electronic, Optical and Magnetic Materials"
] | |
Momentum exchange theory of photon diffraction | [
"Atomic and Molecular Physics, and Optics"
] | ||
La Théorie et la Pratique d'un Éducateur Élisabéthain: Richard Mulcaster C. 1531-1611 | [
"History"
] | ||
GÜNCEL ARKEOLOJİK BULGULAR IŞIĞINDA MÖ 2. BİNYILDA AMASYA BÖLGESİ | [
"Archeology"
] | ||
I requisiti software e le "user story" | [
"Applied Mathematics"
] | ||
Mining production information management system in an open pit based on GIS/GPS/GPRS/RFID | [
"Geotechnical Engineering and Engineering Geology",
"Energy Engineering and Power Technology"
] | ||
Pair production from vacuum at the focus of an X-ray free electron laser | [
"Nuclear and High Energy Physics"
] | ||
Indole-3-acetic acid based tunable hydrogels for antibacterial, antifungal and antioxidant applications | Journal of Macromolecular Science, Part A | [
"Materials Chemistry",
"Polymers and Plastics",
"Ceramics and Composites"
] | |
Stress management | [
"Psychiatry and Mental Health",
"Clinical Psychology"
] | ||
Editorial | [
"Transportation",
"Automotive Engineering"
] | ||
Empirical likelihood ratio for two-sample compound Poisson process problems | [
"Applied Mathematics",
"Statistics, Probability and Uncertainty",
"Modeling and Simulation",
"Statistics and Probability"
] | ||
Novel long-range 1H and 13C n.m.r. isotope effects transmitted via hydrogen bonds in a macrolide antibiotic: bafilomycin A1 | Journal of the Chemical Society, Chemical Communications | [
"Molecular Medicine"
] | |
Micro-buckling of periodically layered composites in regions of stress concentration | Composite Structures | [
"Civil and Structural Engineering",
"Ceramics and Composites"
] | |
Blockade of NFκB activation and renal inflammation by ultrasound-mediated gene transfer of Smad7 in rat remnant kidney | [
"Nephrology"
] | ||
Preface | [
"Condensed Matter Physics"
] | ||
Inactivation of harmful algal bloom by an environmentally friendly photocatalyst under photo-Fenton-like degradation process | Journal of Cleaner Production | [
"Industrial and Manufacturing Engineering",
"Strategy and Management",
"Renewable Energy, Sustainability and the Environment",
"Building and Construction"
] | |
The association between patients’ perceived continuity of care and beliefs about oral anticancer treatment | [
"Oncology"
] | ||
Menu labelling and healthy food choices: a randomised controlled trial | Purpose The purpose of this paper is to examine the effects of different menu labelling formats on healthy food choices in a real restaurant setting. Design/methodology/approach This cross-sectional, randomised and controlled parallel-group trial was conducted in Brazil in 2013. In total, 313 university students were randomly assigned to one of three parallel groups with different menu labelling formats. Of these, data from 233 students were analysed. The others did not attend and were excluded. Intervention Group 1 (n=88) received information in the form of a traffic light plus guideline daily amounts, while Intervention Group 2 (n=74) was presented with ingredients list plus highlighted symbols (IL+S). The control group (n=71) received a menu with no menu labelling. Data were collected on one weekday in a restaurant setting. Trial outcomes were assessed by healthy food choices. Findings Healthy food choices of students who received the menu showing IL+S were significantly higher when compared to the other groups. This same menu labelling format positively affected healthy food choices in women, not overweight participants and in participants who often ate out more than twice a week. Originality/value Menu labelling format presenting ingredients list and highlighted symbols was positively associated with healthy food choices among the university students in Brazil. This type of labelling could be adopted in future legislation on menu labelling in Brazil and around the world. | [
"Food Science",
"Business, Management and Accounting (miscellaneous)"
] | |
Primary Megakaryocytes Reveal a Role for Transcription Factor Nf-E2 in Integrin αiibβ3 Signaling | Platelet integrin αIIbβ3 responds to intracellular signals by binding fibrinogen and triggering cytoskeletal reorganization, but the mechanisms of αIIbβ3 signaling remain poorly understood. To better understand this process, we established conditions to study αIIbβ3 signaling in primary murine megakaryocytes. Unlike platelets, these platelet precursors are amenable to genetic manipulation. Cytokine-stimulated bone marrow cultures produced three arbitrary populations of αIIbβ3-expressing cells with increasing size and DNA ploidy: small progenitors, intermediate-size young megakaryocytes, and large mature megakaryocytes. A majority of the large megakaryocytes bound fibrinogen in response to agonists, while almost none of the smaller cells did. Fibrinogen binding to large megakaryocytes was inhibited by Sindbis virus-mediated expression of isolated β3 integrin cytoplasmic tails. Strikingly, large megakaryocytes from mice deficient in the transcription factor NF-E2 failed to bind fibrinogen in response to agonists, despite normal surface expression of αIIbβ3. Furthermore, while megakaryocytes from wild-type mice spread on immobilized fibrinogen and exhibited filopodia, lamellipodia and Rho-dependent focal adhesions and stress fibers, NF-E2–deficient megakaryocytes adhered poorly. These studies establish that agonist-induced activation of αIIbβ3 is controlled by NF-E2–regulated signaling pathways that mature late in megakaryocyte development and converge at the β3 cytoplasmic tail. Megakaryocytes provide a physiologically relevant and tractable system for analysis of bidirectional αIIbβ3 signaling. | [
"Cell Biology"
] | |
Reshaping Regulation | The Electricity Journal | [
"Management of Technology and Innovation",
"Energy (miscellaneous)",
"Business and International Management"
] | |
The hepatic “nodule” | Gastrointestinal Endoscopy | [
"Gastroenterology",
"Radiology, Nuclear Medicine and Imaging"
] | |
Improvements in Stress, Affect, and Irritability Following Brief Use of a Mindfulness-based Smartphone App: A Randomized Controlled Trial | [
"Applied Psychology",
"Developmental and Educational Psychology",
"Experimental and Cognitive Psychology",
"Health (social science)",
"Social Psychology"
] | ||
Dynamic geomagnetic field models | [
"Space and Planetary Science",
"Geophysics"
] | ||
OPC UA für Industrie 4.0 | Die Kommunikation bei Industrie 4.0 wird nicht mehr auf reinen Daten, sondern auf dem Austausch semantischer Information basieren. Darüber hinaus wird die Übertragungssicherheit eine herausragende Bedeutung haben. Diese Aufgabenstellungen sind Kernpunkte der OPC Unified Architecture (OPC UA). OPC UA enthält eine Beschreibungssprache und die Kommunikationsdienste für Informationsmodelle. Der Beitrag beschreibt, warum dieser Standard universell nutzbar ist. Er kommt bereits in Anwendungsdomänen wie Fertigungs-, Prozess-, Gebäude-, Energieautomatisierung und Condition Monitoring zum Einsatz. | [
"Electrical and Electronic Engineering",
"Atomic and Molecular Physics, and Optics"
] | |
Psychometric Properties of Clinical Performance Ratings | A total of 7931 ratings of 482 third- and fourth-year medical students were gath ered over twelve four-week periods. Ratings were made by multiple raters, house officers, and attending faculty, on fifteen behaviorally-anchored rating scales. The data were factor analyzed separately for each of the twelve periods. | Evaluation & the Health Professions | [
"Health Policy"
] |
Thinking Italian Animals. Human and Posthuman in Modern and Italian Literature and Film | [
"Literature and Literary Theory"
] | ||
Phosphine complexes of main group elements: phosphinomethyl substituted aluminates as anionic phosphine ligands to lithium and X-ray structure of Me2Al(CH2PMe2)2Li(Me2NCH2CH2NMe2) | [
"Molecular Medicine"
] | ||
WITHDRAWN: Persistent sciatic artery aneurysm | [
"Cardiology and Cardiovascular Medicine",
"Surgery"
] | ||
Effect of Maturation on Hemodynamic and Autonomic Control Recovery Following Maximal Running Exercise in Highly Trained Young Soccer Players | [
"Physiology (medical)",
"Physiology"
] | ||
Isolation ofβ-glucan from the cell wall ofSaccharomyces cerevisiae | [
"Organic Chemistry",
"Plant Science",
"Biochemistry",
"Analytical Chemistry"
] | ||
Age-dependent changes of glyoxalase I expression in human brain | [
"Geriatrics and Gerontology",
"Developmental Biology",
"Neurology (clinical)",
"Aging"
] | ||
Effect of Trigonella foenum-graecum L. on Metabolic Activity of CYP2D6 and CYP3A4 | Background: The present study investigated the effect of fenugreek seeds powder and its alcoholic extract on metabolic activity of drug-metabolizing enzymes CYP2D6 and CYP3A4. Materials and Methods: Dextromethorphan (DEX) was used as a probe for measuring metabolic activity, based on its CYP2D6- and CYP3A4-mediated metabolism to dextrorphan (DOR) and 3-methoxymorphinan (3-MM), respectively. For the in vitro investigations, DEX (25µM) was incubated with human liver microsomes and NADPH and tested with and without the fenugreek extract. For the in vivo study, phase I, 6 subjects received a single dose of DEX (30 mg); in phase II, after washout period, the fenugreek seeds powder was administered for 1 week and DEX was administered with its last dose. Results: In vitro, fenugreek extract inhibits CYP2D6-mediated O-demethylation of DEX. Higher concentrations (50 and 100µg/ml) of extract inhibit CYP2D6 and CYP3A4 activity. In vivo results indicated that fenugreek does not significantly inhibit CYP2D6 and CYP3A4 metabolic activity. There was no significant change in the levels of DEX metabolites (DOR 12% and 3-MM 9%) excreted in urine and their urine metabolic ratios (P values: 0.257 and 0.333 DEX/DOR and DEX/3-MM, respectively). Conclusion: In vitro and in vivo observations suggested that fenugreek may not have substantial effect on the metabolic activity of CYP2D6 and CYP3A4. | [
"Complementary and Alternative Medicine"
] | |
Étude spectrographique de complexes dinucléaires pontés | [
"Biochemistry"
] | ||
Human Factors Applications in Teleoperator Design and Operation | [
"Condensed Matter Physics",
"Nuclear Energy and Engineering",
"Nuclear and High Energy Physics"
] | ||
The Conformation of Poly-L-tyrosine in Quinoline from Dielectric Dispersion Studies | [
"Colloid and Surface Chemistry",
"Biochemistry",
"Catalysis"
] | ||
A Stereoselective Oxy-Michael Route to Protected β-Aryl-β-Hydroxy-α-Amino Acids | [
"Organic Chemistry"
] | ||
1491 PUBLICATION The usefulness of continuous administration of hypoxic cytotoxin combined with mild temperature hyperthermia, with reference to the effects on quiescent cell populations in solid tumors | European Journal of Cancer Supplements | [
"Cancer Research",
"Oncology"
] | |
Coordination constraints during bimanual versus unimanual performance conditions | Neuropsychologia | [
"Behavioral Neuroscience",
"Cognitive Neuroscience",
"Experimental and Cognitive Psychology"
] | |
decapentaplegic is required for arrest in G1 phase during Drosophila eye development | SUMMARY During eye development in Drosophila, cell cycle progression is coordinated with differentiation. Prior to differentiation, cells arrest in G1 phase anterior to and within the morphogenetic furrow. We show that Decapentaplegic (Dpp), a TGF-β family member, is required to establish this G1 arrest, since Dpp-unresponsive cells located in the anterior half of the morphogenetic furrow show ectopic S phases and ectopic expression of the cell cycle regulators Cyclins A, E and B. Conversely, ubiquitous over-expression of Dpp in the eye imaginal disc transiently inhibits S phase without affecting Cyclin E or Cyclin A abundance. This Dpp-mediated inhibition of S phase occurs independently of the Cyclin A inhibitor Roughex and of the expression of Dacapo, a Cyclin E-Cdk2 inhibitor. Furthermore, Dpp-signaling genes interact genetically with a hypomorphic cyclin E allele. Taken together our results suggest that Dpp acts to induce G1 arrest in the anterior part of the morphogenetic furrow by a novel inhibitory mechanism. In addition, our results provide evidence for a Dpp-independent mechanism that acts in the posterior part of the morphogenetic furrow to maintain G1 arrest. | Development | [
"Developmental Biology",
"Molecular Biology"
] |
Singular and Plural Pronominal Reference in Spanish | [
"Linguistics and Language",
"Language and Linguistics",
"Experimental and Cognitive Psychology"
] | ||
Stable surface coating of silicone elastomer with phosphorylcholine and organosilane copolymer with cross-linking for repelling proteins | [
"Colloid and Surface Chemistry",
"Physical and Theoretical Chemistry",
"Surfaces and Interfaces",
"Biotechnology"
] | ||
PRODUCTION, PRELIMINARY CHARACTERIZATION, AND BIOACTIVITIES OF EXOPOLYSACCHARIDES FROMPleurotus geesteranus 5# | Preparative Biochemistry and Biotechnology | [
"Biochemistry",
"Biotechnology"
] | |
Coupling of visual to auditory cues during phonotactic approach in the phaneropterine bushcricket Poecilimon affinis | [
"Behavioral Neuroscience",
"Animal Science and Zoology",
"Physiology",
"Ecology, Evolution, Behavior and Systematics"
] | ||
Spin-valve and tunnel-valve structures with in situ in-stack bias | [
"Electrical and Electronic Engineering",
"Electronic, Optical and Magnetic Materials"
] |
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