Title stringlengths 0 905 | Abstract stringlengths 0 11.3k | Container_Title stringlengths 0 126 | Subject listlengths 1 13 |
|---|---|---|---|
The Accuracy of Noninvasive Hemoglobin Monitoring Using the Radical-7 Pulse CO-Oximeter in Children Undergoing Neurosurgery | [
"Anesthesiology and Pain Medicine"
] | ||
EFFECT OF TRAINING ON VO2 KINETICS IN RELATION TO LACTATE THRESHOLD | [
"Physical Therapy, Sports Therapy and Rehabilitation",
"Orthopedics and Sports Medicine"
] | ||
Effect of a pyrrolidinium zwitterion on charge/discharge cycle properties of Li/LiCoO2 and graphite/Li cells containing an ionic liquid electrolyte | Journal of Power Sources | [
"Electrical and Electronic Engineering",
"Physical and Theoretical Chemistry",
"Energy Engineering and Power Technology",
"Renewable Energy, Sustainability and the Environment"
] | |
Kinetics of the Complexation of Dioxouranium(VI) with Chlorophosphonazo III | [
"Physical and Theoretical Chemistry"
] | ||
The effects of two free-floating plants ( Eichhornia crassipes and Pistia stratiotes ) on the burrow morphology and water quality characteristics of pond loach ( Misgurnus anguillicaudatus ) habitat | [
"Ecology",
"Aquatic Science",
"Ecology, Evolution, Behavior and Systematics"
] | ||
3D simulation of the matter transport by surface diffusion within a level-set context | European Journal of Computational Mechanics | [
"Mechanical Engineering",
"Mechanics of Materials",
"Modeling and Simulation"
] | |
Forum | [
"Atomic and Molecular Physics, and Optics"
] | ||
Editorial Board | [
"Building and Construction"
] | ||
Impact of the exposome on food allergy development | [
"Immunology",
"Immunology and Allergy"
] | ||
A controlled trial of multiphasic screening in middle-age: results of the South-East London Screening Study* | [
"Epidemiology"
] | ||
Current Status and Issues with Conventional Technology and Anammox Treatment in Nitrogen Removal from Swine Wastewater | [
"Earth-Surface Processes"
] | ||
Human pharmacokinetics of N-L-leucyl-doxorubicin, a new anthracycline derivative, and its correlation with clinical toxicities | [
"Pharmacology (medical)",
"Pharmacology"
] | ||
Duplex ultrasound criteria for in-stent restenosis of mesenteric arteries | [
"Cardiology and Cardiovascular Medicine",
"Surgery"
] | ||
Editorial Board | Electrochemistry Communications | [
"Electrochemistry"
] | |
Regulation of Hepatocyte Growth Factor Activator Inhibitor 2 by Hypoxia in Breast Cancer | Abstract Purpose: To examine the in vitro regulation of hepatocyte growth factor activator inhibitor type 2 (HAI-2) in breast cancer cells and the in vivo predictive role for the efficacy of chemoendocrine primary therapy in patients with breast cancer. Materials and Methods: HAI-2 regulation was studied in a panel of breast cancer cell lines comparing normoxia to hypoxia. The effect of HIF-1α RNAi on HAI-2 expression was evaluated in these cells. HAI-2 was examined in breast cancer using in situ hybridization and immunohistochemistry. The HAI-2 predictive role was assessed in T2-4 N0-1 breast cancers (n = 177) enrolled in a neoadjuvant randomized trial comparing epirubicin versus epirubicin + tamoxifen. Results: HAI-2 mRNA and protein were regulated by hypoxia in the c-erbB2–positive cell lines, SKBR3 and BT474, and controlled by HIF-1α in these cells. Immunohistochemistry confirmed this profile with high expression of HAI-2 in c-erbB2–positive breast cancer. HAI-2 was correlated with T status (P < 0.004), node involvement (P = 0.01), and c-erbB2 expression (P = 0.05). HAI-2 also correlated with hypoxia markers such as carbonic anhydrase IX expression (P = 0.01) and HIF-1α. Additionally, high levels of HAI-2 were a significant predictor for poor clinical complete response to preoperative epirubicin in univariate (P = 0.01) and multivariate analyses (P = 0.016). No correlation with disease-free survival and survival was observed. Conclusion: HAI-2 expression in breast cancer correlated with tumor aggressiveness in vivo. It is a HIF target in c-erbB2–positive cells and it is an independent negative predictive factor of efficacy of anthracycline therapy. The interaction of HAI-2 with the hepatocyte growth factor activation pathway may be a useful site for therapeutic intervention. | [
"Cancer Research",
"Oncology"
] | |
China economic review 30 years | [
"Economics and Econometrics",
"Finance"
] | ||
Ingratiation and the use of power. | [
"Sociology and Political Science",
"Social Psychology"
] | ||
Corrigendum to “Towards a dendrochronologically refined date of the Laacher See eruption around 13,000 years ago” [Quat. Sci. Rev. 229 (2020) 106128] | [
"Geology",
"Archeology",
"Ecology, Evolution, Behavior and Systematics",
"Global and Planetary Change"
] | ||
HIV-1 Nef Interacts with LMP7 To Attenuate Immunoproteasome Formation and Major Histocompatibility Complex Class I Antigen Presentation | The ubiquitin-proteasome system (UPS) is essential for the degradation of damaged proteins, which takes place in the proteasome. Upon activation by cytokines, the catalytic subunits of the proteasome are replaced by distinct isoforms resulting in the formation of an immunoproteasome (iProteasome). iProteasome generates peptides used by major histocompatibility complex class I (MHC-I) for antigen presentation and is essential for immune responses. HIV-1 is the causative agent of AIDS, and HIV-1-specific cytotoxic T lymphocytes (CTLs) provide immune responses limiting viral replication. This study identifies a distinct mechanism by which HIV-1 promotes immune evasion. The viral protein negative regulatory factor (Nef) interacts with a component of iProteasome, LMP7, attenuating iProteasome formation and protein degradation function, and thus repressing the MHC-I antigen presentation activity of MHC-I. Therefore, HIV-1 targets LMP7 to inhibit iProteasome activation, and LMP7 may be used as the target for the development of anti-HIV-1/AIDS therapy. | [
"Virology",
"Microbiology"
] | |
Kinetic Characterization of the Function of Myosin Loop 4 in the Actin−Myosin Interaction | Biochemistry | [
"Biochemistry"
] | |
The impact of the COVID-19 pandemic on transcatheter aortic valve implantation (TAVI) service: a United Kingdom tertiary centre experience | Abstract Background/Introduction Untreated, symptomatic, severe aortic stenosis carries significant mortality and morbidity. Timely intervention is pivotal to ensure patient safety. The COVID-19 pandemic created unprecedented challenges to the UK's National Health Service (NHS), resulting in the deferral of all elective work, including TAVI services from March 2020. Purpose To evaluate clinical outcomes and time delays in patients undergoing TAVI during the pandemic period compared to an age and risk factor-matched cohort of patients prior to COVID-19. We hypothesized that there were significant time delays, more emergency procedures and related adverse outcomes in patients who underwent TAVI during the pandemic period. Methods We analysed prospectively collected data (patient characteristics, procedural details, complications and in-hospital outcomes) of 210 consecutive patients who underwent TAVI between March 2019 and February 2021 in a tertiary centre in the UK (The centre serves for a population of 2.5 million and provided in-patient treatment for 5590 COVID-positive patients over a 12 month period). We compared time-lags from an initial referral to outpatient review, CT aortograms, valve implantation and 30-day mortality between patients who underwent TAVI between March 2019 and Feburary 2020 (N=134) and those who underwent TAVI between March 2020 and February 2021 (COVID Group=76). Results The mean age of the cohort was 81.4±6.6 years and majority were females (51%) and were in moderate risk category (EuroSCORE II=4.55±5.5). Of the total cohort, 4 (5.3%) patients acquired COVID-19 pneumonia during the hospital stay. The age, cardiovascular comorbidities and risk scores were comparable between the control group and the COVID cohort. (Table 1). There were no significant differences in procedural complications in the control group compared to the COVID-19 group (Table 1). The median waiting time from referral to TAVI clinic was significantly shorter in the COVID-19 group (33 (8–66) vs. 51 (17–89) days (P=0.04)) and there was no significant difference in time delays for CT aortogram, MDT or TAVI procedure between the two groups. The median length of stay (2 (2–4) vs 2.5 (2–9) days) and 30 day mortality (1.4% vs 5.3%) was comparable between the two groups (Table 1). Conclusion Contrary to our hypothesis, our analysis demonstrated that there were no significant time delays, excess complications or mortality in TAVI procedures during the COVID-19 pandemic period despite the excess burden imposed on our local health services. More importantly, very few TAVI patients acquired COVID-19 infection during in-hospital stay. This is likely due to prompt identification of innovative ways of re-configuring an existing local patient pathway, by the TAVI team, to deliver safe and uninterrupted TAVI services during this unprecedented pandemic setting. Funding Acknowledgement Type of funding sources: None. Figure 1. Referral times | European Heart Journal | [
"Cardiology and Cardiovascular Medicine"
] |
Editorial Board | [
"Electrical and Electronic Engineering",
"Energy Engineering and Power Technology"
] | ||
Goal Setting – Ziele smart formulieren | [
"Psychiatry and Mental Health",
"Applied Psychology"
] | ||
The Bed Case | [
"Energy Engineering and Power Technology",
"Fuel Technology"
] | ||
IP229 Proposal of a Multicentric-Based Score for Graft Patency in Below-knee Femoropopliteal Bypass With Heparin-Bonded ePTFE Graft in Patients With Critical Limb Ischemia | Journal of Vascular Surgery | [
"Cardiology and Cardiovascular Medicine",
"Surgery"
] | |
APS, an adapter protein with a PH and SH2 domain, is a substrate for the insulin receptor kinase | APS (adapter protein with a PH and SH2 domain) is the newest member of a family of tyrosine kinase adapter proteins including SH2-B and Lnk. We previously identified SH2-B as an insulin-receptor-binding protein and substrate [Kotani, Wilden and Pillay (1998) Biochem J. 335, 103-109]. Here we show that APS interacts with the insulin receptor kinase activation loop through its SH2 domain and insulin stimulates the tyrosine-phosphorylation of APS. Furthermore, the phosphorylation of activation-loop tyrosine residues 1158 and 1162 are required for this interaction. | [
"Cell Biology",
"Molecular Biology",
"Biochemistry"
] | |
Announcements & calendar | [
"Physiology (medical)",
"Biochemistry"
] | ||
[Front cover] | [
"Electrical and Electronic Engineering"
] | ||
Tetracapsuloides bryosalmonae and PKD in juvenile wild salmonids in Denmark | [
"Aquatic Science",
"Ecology, Evolution, Behavior and Systematics"
] | ||
A Streak Spectrograph for the Analysis of Short-Lived Intermediates Generated by Flash Photolysis or Pulse Radiolysis | Applied Optics | [
"Industrial and Manufacturing Engineering",
"Materials Science (miscellaneous)",
"Business and International Management"
] | |
High strength kiloampere Bi2Sr2CaCu2Oxcables for high-field magnet applications | [
"Materials Chemistry",
"Electrical and Electronic Engineering",
"Metals and Alloys",
"Condensed Matter Physics",
"Ceramics and Composites"
] | ||
David Holloran Lumsdaine, Moral vision in International Politics: The Aid Regime, 1949—1989Princeton: Princetion University Press, 1993), 416 pp., $49.50 cloth, $16.95 paper | Ethics & International Affairs | [
"Political Science and International Relations",
"Philosophy"
] | |
Estimates of uncertainty of measurement from proficiency testing data: a case study | [
"Safety, Risk, Reliability and Quality",
"Instrumentation"
] | ||
Seasonal variation in the antifouling defence of the temperate brown algaFucus vesiculosus | Biofouling | [
"Water Science and Technology",
"Applied Microbiology and Biotechnology",
"Aquatic Science"
] | |
Utterance modifiers and universals of grammatical borrowing | [
"Linguistics and Language",
"Language and Linguistics"
] | ||
Busy building the evidence base | [
"Pediatrics"
] | ||
Word length effect in free recall of randomly assembled word lists | [
"Cellular and Molecular Neuroscience",
"Neuroscience (miscellaneous)"
] | ||
Les Traumatismes du Thorax. By Jean-Chafles Sournia. 9 1/2 × 6 in. Pp. 354, with 92 illustrations and 9 plates. 1958. Paris: Gaston Doin et Cie. 4,800 fr | [
"Surgery"
] | ||
The Fulcra of Conflict. | Journal of Educational Psychology | [
"Developmental and Educational Psychology",
"Education"
] | |
Expandable, dual-excipient fibrous dosage forms for prolonged delivery of sparingly-soluble drugs | [
"Pharmaceutical Science"
] | ||
Christina R. Victor, Old Age in Modern Society: A Textbook of Social Gerontology, Croom Helm, Beckenham, Kent, 1987, 338 pp., £22.50 hbk, ISBN 0 7099 2628 6, £10.95 hbk, ISBN 0 7099 2630 8. | [
"Public Health, Environmental and Occupational Health",
"Geriatrics and Gerontology",
"Arts and Humanities (miscellaneous)",
"Social Psychology",
"Health (social science)"
] | ||
A Challenge for Engineering Biomimetic Microvascular Models: How do we Incorporate the Physiology? | The gap between in vitro and in vivo assays has inspired biomimetic model development. Tissue engineered models that attempt to mimic the complexity of microvascular networks have emerged as tools for investigating cell-cell and cell-environment interactions that may be not easily viewed in vivo. A key challenge in model development, however, is determining how to recreate the multi-cell/system functional complexity of a real network environment that integrates endothelial cells, smooth muscle cells, vascular pericytes, lymphatics, nerves, fluid flow, extracellular matrix, and inflammatory cells. The objective of this mini-review is to overview the recent evolution of popular biomimetic modeling approaches for investigating microvascular dynamics. A specific focus will highlight the engineering design requirements needed to match physiological function and the potential for top-down tissue culture methods that maintain complexity. Overall, examples of physiological validation, basic science discoveries, and therapeutic evaluation studies will emphasize the value of tissue culture models and biomimetic model development approaches that fill the gap between in vitro and in vivo assays and guide how vascular biologists and physiologists might think about the microcirculation. | Frontiers in Bioengineering and Biotechnology | [
"Biomedical Engineering",
"Histology",
"Bioengineering",
"Biotechnology"
] |
Correcting aberrations of a transverse-field neutron resonance spin echo instrument | Neutron resonance spin echo (NRSE) technique has the potential to increase the Fourier time and energy resolution in neutron scattering by using radio frequency (rf) neutron spin-flippers. However, aberrations arising from variations in the neutron path length between the rf flippers reduce the polarization. Here, we develop and test a transverse static-field magnet, a series of which are placed between the rf flippers, to correct for these aberrations. The prototype correction magnet was both simulated in an NRSE beamline using McStas, a Monte Carlo neutron ray-tracing software package, and measured using neutrons. The results from the prototype demonstrate that this static-field design corrects for transverse-field NRSE aberrations. | [
"Instrumentation"
] | |
Hipotiroidismo en el anciano | [
"Family Practice",
"Public Health, Environmental and Occupational Health"
] | ||
‘We Are Drinking Diseases’: Perception of Water Insecurity and Emotional Distress in Urban Slums in Accra, Ghana | Water security is critical to the health and well-being of people around the world, especially among populations experiencing water stresses and rapid urbanization in low- to middle-income countries (LMICs). Recent research suggests water insecurity is associated with negative mental health outcomes. Despite global improvement in access to safe water across the world, the World Health Organization (WHO) reports that access to safe water in urban areas has not changed significantly or has stagnated in certain countries. In most African cities, entrepreneurial water vendors have stepped up to fill supply gaps in the formal delivery system by selling vended water. As part of a larger research program that aims to assess and analyze public perceptions around vended water, this paper explores the links connecting water insecurity and emotional distress among urban slum dwellers who mostly use vended water in Accra, Ghana. We used a parallel mixed-methods approach. Our quantitative results show that water-insecure households (OR = 2.23, p = 0.01) were more likely to report emotional distresses compared to water-secure households. However, households with improved sanitation (OR = 0.28, p = 0.01) and those willing to participate for improved water and sanitation (OR = 0.28, p = 0.01) were less likely to report emotional distress. Our qualitative results offered support for the quantitative results, as participants not only hold various perceptions regarding the safety and quality of vended water but expressed emotional distresses such as fear of contamination, discomfort, worry over arbitrary change in prices, and anxiety. The implications of the results for policy and practice, specifically to ensuring access to safe water, are discussed. | [
"Health, Toxicology and Mutagenesis",
"Public Health, Environmental and Occupational Health"
] | |
Highly birefringent chalcogenide optical fiber for polarization-maintaining in the 3-85 µm mid-IR window | Optics Express | [
"Atomic and Molecular Physics, and Optics"
] | |
CLINICAL CHALLENGE | [
"Animal Science and Zoology"
] | ||
J. G. Cummins, "El habla de Coria y sus cercanías" (Book Review) | [
"Literature and Literary Theory",
"Linguistics and Language",
"Language and Linguistics"
] | ||
Degenerative Changes of the Menisci of the Knee | [
"Radiology, Nuclear Medicine and Imaging",
"Radiological and Ultrasound Technology"
] | ||
Effect of anti alphafetoprotein antibody (AAA) on the AFP producing hepatoma | [
"Oncology"
] | ||
The current pattern of gestational age-related anthropometric parameters of term Nigerian neonates | [
"Pediatrics, Perinatology and Child Health"
] | ||
The Impact of Methylenetetrahydrofolate Reductase C677T Gene Polymorphism on Engraftment after Allogeneic Hematopoetic Cell Transplantation. | Abstract Methotrexate (MTX) is an antifolate agent used to prevent graft versus host disease (GVHD) in allogeneic hemapoietic cell transplantation (AHCT). The effectiveness of MTX is largely attributable to its role of MTHR and its gene polymorphism is a common (10–12% homozygote and 40% heterozygote) variation in the population. It was shown by Ulrich et al that C677T polymorphism leads to variations in toxicities. Depending on to this finding, we investigated whether methylenetetrahyrofolate reductase (MTHFR) C677T gene polymorphism has any affect on engraftment kinetics of patients undergoing AHCT. We retrospectively analyzed our cohort of 82 allogeneic stem cell recipients whose MTHFR gene polymorphism of C677T region was analyzed by RQ-PCR for the pretransplant evaluation of hereditary thrombophilia. The patient’s median age was 31 (range, 14–50) years, with a M/F: 50/32 and diagnosis; 35 AML, 26 CML, 12 ALL and 9 other. Nearly all the patients received ablative conditioning regimen (BU-CY) or CY-TBI. All the patients received CSA and short term MTX for GVHD prophylaxis. Stem cell source was bone marrow (BM) in 23 and peripheral blood (PB) in 59. MTHFR gene polymorphism was detected in 32 (39%) of all patients, whose 90% were heterozygote (MTHFR HeZ). When we compared the engraftment kinetics, granulocyte engraftment was found to be late in MTHFR HeZ group (neutrophil 1000 median 19 vs 17 d; p=0.01) but no difference in platelet engraftment. In order to eliminate the effect of stem cell source on engraftment kinetics we have done the same analysis for BM and PB group separately. We have observed that MTHFR gene polymorphism had a prominent effect on BM recipients, as both neutrophil 500 and 1000 and also platelet engraftments were affected (granulocyte 500 median 21 vs 15 p=0.005; granulocyte 1000 median 22.5 vs 17 p=0.0001 and plt 20 median 27 vs 21 p=0.03) significantly. On the contrary, there was no difference in the PB group. There was no difference in acute GVHD incidence. Our knowledge on epigenetic data will help us on tailoring the chemotherapy regimen for conditioning and GvHD prophylaxis in transplant recipients. Our data on a limited patient size suggests that the presence of MTHFR HeZ may have an impact on allo HCT recipients’ engraftment kinetics while using MTX for GVHD prophylaxis and BM as stem cell source. | [
"Cell Biology",
"Hematology",
"Immunology",
"Biochemistry"
] | |
"Parenting" Teenage Parents: A Clinician's Notes | [
"Social Sciences (miscellaneous)",
"Developmental and Educational Psychology",
"Education"
] | ||
Molecular and Immunohistochemical Study of Platelet Derived Growth Factor Receptor Alpha in KIT Negative Gastrointestinal Stromal Tumors; the First Report from Iran | [
"Gastroenterology",
"Hepatology"
] | ||
Coordination of a supply chain with a loss-averse retailer under two types of contracts | [
"Management of Technology and Innovation",
"Information Systems and Management",
"Strategy and Management",
"Computer Science Applications"
] | ||
Computer-Based Patient Data Management: Effective Use of Equipment and Personnel | [
"Obstetrics and Gynecology"
] | ||
Editorial Board | [
"Psychiatry and Mental Health"
] | ||
The Impact of Professional Noticing on Teachers' Adaptations of Challenging Tasks | Mathematical Thinking and Learning | [
"Developmental and Educational Psychology",
"Education"
] | |
Comparison of methyl-CCNU and CCNU in patients with advanced forms of Hodgkin's disease, lymphosarcoma and reticulum cell sarcoma | [
"Cancer Research",
"Oncology"
] | ||
L’invention de la décentralisation | Parliaments, Estates and Representation | [
"Sociology and Political Science"
] | |
Patent Digest | [
"Materials Chemistry",
"Polymers and Plastics"
] | ||
Air mediates the impact of a compliant hemisphere on a rigid smooth surface | When a soft elastic body impacts upon a smooth solid surface, the intervening air fails to drain, deforming the impactor. High-speed imaging with the VFT reveal rich dynamics and sensitivity to the impactor's elastic properties and the impact velocity. | [
"Condensed Matter Physics"
] | |
The Cosmic Baryon Budget | [
"Space and Planetary Science",
"Astronomy and Astrophysics"
] | ||
Exploring the risk information gap. Research into information supply and information demand of different parties concerned | Safety Science | [
"Public Health, Environmental and Occupational Health",
"Safety Research",
"Safety, Risk, Reliability and Quality"
] | |
On the influence of map analysis formulation in the estimation of wind field derivatives | [
"Atmospheric Science"
] | ||
In Search of Annual Legumes to Improve Forage Sorghum Yield and Nutritive Value in the Southern High Plains | [
"Plant Science",
"Soil Science",
"Agronomy and Crop Science"
] | ||
Transannular Diels-Alder reaction of 14-membered macrocyclic trienes. Part II: Experimental results and synthetic potential | Tetrahedron Letters | [
"Organic Chemistry",
"Drug Discovery",
"Biochemistry"
] | |
On cyanmethaemoglobin and photomethaemoglobin | [
"Physiology"
] | ||
Dissolved organic carbon uptake in streams: A review and assessment of reach-scale measurements | [
"Paleontology",
"Atmospheric Science",
"Soil Science",
"Water Science and Technology",
"Ecology",
"Aquatic Science",
"Forestry"
] | ||
Subsurface flows associated with non-Joy oriented active regions: a case study | [
"Computer Science Applications",
"History",
"Education"
] | ||
Chemically functionalized conical PET nanopore for protein detection at the single-molecule level | [
"Electrochemistry",
"Biomedical Engineering",
"Biophysics",
"Biotechnology"
] | ||
The case of Invernizzi (Kraft Italia) | After a number of years of advertising efforts aimed at sustaining the brand Invernizzi, in 2000 Kraft decided to focus its marketing efforts on sales growth. Its portfolio is composed of four different categories of fresh cheese; three of them are traditional Italian products (Mozzarella, Crescenza and Gorgonzola) and one (“Giravolte”) is a ready to cook cheese that, after its launch in 1998, achieved remarkable results. The brand Invernizzi (born at the beginning of the last century) has a good reputation in Italy especially among the baby boom generation. However from mid‐1990s (like other classic brands) it started to suffer increasing competition arising from private labels and low priced products. Italian consumers continue to expect quality, innovation and service but they are paying more and more attention to price. In this situation Kraft marketing management is wondering how much the company should invest in new products (like Giravolte) and what should be, in the portfolio, the role of the classic products that are still leading their markets. | [
"Food Science",
"Business, Management and Accounting (miscellaneous)"
] | |
Dental caries and hypoplastic amelogenesis imperfecta: Clinical, structural, biochemical and molecular approaches | Microbial Pathogenesis | [
"Infectious Diseases",
"Microbiology"
] | |
On the definition of exergy efficiencies for petroleum systems: Application to offshore oil and gas processing | [
"Pollution",
"Mechanical Engineering",
"Building and Construction",
"Electrical and Electronic Engineering",
"Industrial and Manufacturing Engineering",
"Civil and Structural Engineering"
] | ||
Immunochemical methods in cell and molecular biology, (biological techniques series) | [
"Endocrinology",
"Biochemistry"
] | ||
Induction of Hepatitis E Virus Anti-ORF3 Antibodies from Systemic Administration of a Muscle-Specific Adeno-Associated Virus (AAV) Vector | The hepatitis E virus (HEV) is a major global health problem, leading to large outbreaks in the developing world and chronic infections in the developed world. HEV is a non-enveloped virus, which circulates in the blood in a quasi-enveloped form. The quasi-envelope protects HEV particles from neutralising anti-capsid antibodies in the serum; however, most vaccine approaches are designed to induce an immune response against the HEV capsid. In this study, we explored systemic in vivo administration of a novel synthetic and myotropic Adeno-associated virus vector (AAVMYO3) to express the small HEV phosphoprotein ORF3 (found on quasi-enveloped HEV) in the musculature of mice, resulting in the robust and dose-dependent formation of anti-ORF3 antibodies. Neutralisation assays using the serum of ORF3 AAV-transduced mice showed a modest inhibitory effect on the infection of quasi-enveloped HEV in vivo, comparable to previously characterised anti-ORF3 antibodies used as a control. The novel AAVMYO3 capsid used in this study can serve as a versatile platform for the continued development of vector-based vaccines against HEV and other infectious agents, which could complement traditional vaccines akin to the current positive experience with SARS-CoV-2. | [
"Virology",
"Infectious Diseases"
] | |
The validity of the modified equation for nonlinear shock waves | [
"Computer Science Applications",
"Physics and Astronomy (miscellaneous)",
"Applied Mathematics",
"Computational Mathematics",
"Modeling and Simulation",
"Numerical Analysis"
] | ||
PERTURBATION OF PHOSPHOLIPID MEMBRANES BY GIBBERELLINS | [
"Plant Science",
"Physiology"
] | ||
Letter to the Editor: Emergency Department Versus Operating Suite Intubation in Operative Trauma Patients: Does Location Matter? | [
"Surgery"
] | ||
Review of the application and efficacy of extracorporeal shockwave therapy in equine tendon and ligament injuries | [
"Equine"
] | ||
Effect of inhibitors of protein synthesis and DNA replication on the induction of proteolytic activities, caspase-like activities and cell death in the unicellular chlorophyteDunaliella tertiolecta | [
"Plant Science",
"Aquatic Science"
] | ||
Application usability levels: a framework for tracking project product progress | The space physics community continues to grow and become both more interdisciplinary and more intertwined with commercial and government operations. This has created a need for a framework to easily identify what projects can be used for specific applications and how close the tool is to routine autonomous or on-demand implementation and operation. We propose the Application Usability Level (AUL) framework and publicizing AULs to help the community quantify the progress of successful applications, metrics, and validation efforts. This framework will also aid the scientific community by supplying the type of information needed to build off of previously published work and publicizing the applications and requirements needed by the user communities. In this paper, we define the AUL framework, outline the milestones required for progression to higher AULs, and provide example projects utilizing the AUL framework. This work has been completed as part of the activities of the Assessment of Understanding and Quantifying Progress working group which is part of the International Forum for Space Weather Capabilities Assessment. | [
"Space and Planetary Science",
"Atmospheric Science"
] | |
The visual component to saccadic compression | Journal of Vision | [
"Sensory Systems",
"Ophthalmology"
] | |
XVI. Auszüge | [
"Inorganic Chemistry",
"Condensed Matter Physics"
] | ||
The evaluation of the impact of titania nanotube covers morphology and crystal phase on their biological properties | [
"Biomedical Engineering",
"Biomaterials",
"Bioengineering",
"Biophysics"
] | ||
Omental Infarction in Children: Color Doppler Sonography Correlated with Surgery and Pathology Findings | American Journal of Roentgenology | [
"Radiology, Nuclear Medicine and Imaging"
] | |
Spiritual Values: A Question of Existence in William Faulkner’s the Sound and the Fury and Absalom, Absalom! | Values are the necessary code for human conduct for harmonious life of integrity. Human beings are rational; they have reason for each and every action. Their actions bring out their beliefs, attitudes and custom. William Faulkner in his novels The Sound and the Fury and Absalom, Absalom! delivers perfect medium of the values in spirituality and absence in it. This research work focuses on the absence of spiritual values which lead to confusion and disorientation in the lives of many characters. All the characters discussed in the works of William Faulkner gives a perfect medium of trouble not only to self but also to others just because of the least consideration that is given to the values based on spirituality. | [
"Electrical and Electronic Engineering",
"Mechanics of Materials",
"Civil and Structural Engineering"
] | |
Un futuro incierto | SEMERGEN - Medicina de Familia | [
"Family Practice",
"Public Health, Environmental and Occupational Health"
] | |
Estimation of the Concentration Parameter in von Mises-Fisher Distributions | [
"Applied Mathematics",
"Statistics, Probability and Uncertainty",
"Agricultural and Biological Sciences (miscellaneous)",
"Statistics and Probability"
] | ||
Eigenfunctions in the Galerkin method of tidal current modelling | Continental Shelf Research | [
"Geology",
"Aquatic Science",
"Oceanography"
] | |
Similarity Indices for Spatia I Ecological Data | [
"Applied Mathematics",
"Statistics and Probability"
] | ||
Targeting the Osmotic Stress Response for Strain Improvement of an Industrial Producer of Secondary Metabolites | [
"Applied Microbiology and Biotechnology",
"Biotechnology"
] | ||
Accurate whole‐mount bone and cartilage staining requires acid‐free conditions | [
"Ecology, Evolution, Behavior and Systematics",
"Histology",
"Biotechnology",
"Anatomy"
] | ||
NbCl5 a multifunctional reagent for the synthesis of new halogenated aminoquinoline compounds through innovative one-pot reaction and the acidochromism effect | Tetrahedron | [
"Organic Chemistry",
"Drug Discovery",
"Biochemistry"
] | |
The Current State of Mobile Phone Apps for Monitoring Heart Rate, Heart Rate Variability, and Atrial Fibrillation: Narrative Review | [
"Health Informatics"
] | ||
Effects of Temperature, Sonication Time, and Power Settings on Size Distribution and Extractability of Total Wheat Flour Proteins as Determined by Size-Exclusion High-Performance Liquid Chromatography | [
"Organic Chemistry",
"Food Science"
] | ||
The Arkhangel’skiĭ–Tall problem: a consistent counterexample | [
"Algebra and Number Theory"
] | ||
The Insertion of ‘Twist’ into Yarns by Means of Air-jets. Part I: An Experimental Study of Air-jet Spinning | Journal of the Textile Institute | [
"Industrial and Manufacturing Engineering",
"Polymers and Plastics",
"Materials Science (miscellaneous)"
] | |
Brass Matrix of a Butcher | [
"Library and Information Sciences",
"Literature and Literary Theory",
"Linguistics and Language",
"Language and Linguistics"
] | ||
The Estrella de Sevilla and Claramonte (Book Review) | [
"Literature and Literary Theory",
"Linguistics and Language",
"Language and Linguistics"
] |
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