Title stringlengths 0 905 | Abstract stringlengths 0 11.3k | Container_Title stringlengths 0 126 | Subject listlengths 1 13 |
|---|---|---|---|
A NUMERICAL STUDY OF UNSTEADY INFILTRATION INTO TWO-LAYERED SOIL | JP Journal of Heat and Mass Transfer | [
"Atomic and Molecular Physics, and Optics"
] | |
The Utility of Remote Video Technology in Continuing Neurosurgical Care in the COVID-19 Era: Reflections from the Past Year | [
"Neurology (clinical)",
"Surgery"
] | ||
Reconstruction of the (310), (210) and (110) surfaces in fcc metals | [
"Materials Chemistry",
"Surfaces, Coatings and Films",
"Surfaces and Interfaces",
"Condensed Matter Physics"
] | ||
The Restoration Rake-Heor: Transformations in Sexual Understanding in Seventeenth-Century England | [
"Museology",
"Archeology",
"History"
] | ||
Some Preliminary Observations on the Intergovernmental Conferences: The Relations between the Concepts of a Common Market, a Monetary Union, an Economic Union, a Political Union and So | [
"Law",
"Political Science and International Relations"
] | ||
Individual variation in Black-capped chickadee (Poecile atricapillus) foraging behavior in response to a predator model. | [
"Psychology (miscellaneous)",
"Ecology, Evolution, Behavior and Systematics"
] | ||
Direct Measurements of Half-Cycle Reaction Heats during Atomic Layer Deposition by Calorimetry | Chemistry of Materials | [
"Materials Chemistry"
] | |
Visualität und Multimodalität in wissenschaftlichen Präsentationen | Abstract In recent times presentations have drawn the attention of scientific interest as a new form of communication. In visualization of abstract structures or relationships in scholarly presentations using diagrams, different medial layers of meaning are conjoined in a very special way. The present paper examines firstly the multimodal structure of presentations and the mechanisms of establishing cross-modality coherence. Then the results of a reception experiment are discussed that gives rise to the assumption that multimodality can in fact improve the understanding of scholarly presentations. In the final part of the paper the production of an abstract visualization in a scholarly presentation is exemplified with regard to the solution of disambiguation and linearization problems. We claim that abstract visualizations in presentations are used to produce narratives by the speaker, and without such narratives this kind of visualization cannot be understood properly. | [
"Linguistics and Language",
"Developmental and Educational Psychology",
"Language and Linguistics"
] | |
Complications of Fat Grafting | [
"Surgery"
] | ||
Editorial Board EOV | [
"Management, Monitoring, Policy and Law",
"Development",
"Geography, Planning and Development"
] | ||
A Randomized, Placebo-Controlled Trial of Gamma Linolenic Acid as an Add-on Therapy to Minocycline for the Treatment of Rosacea | [
"Dermatology"
] | ||
A computer-aided simulation model for the I–V characteristic of M-n-p silicon Schottky-barrier diodes produced by use of low-energy arsenic-ion implantation | [
"Materials Chemistry",
"Electrical and Electronic Engineering",
"Condensed Matter Physics",
"Electronic, Optical and Magnetic Materials"
] | ||
Evolutionary Relationships of the Caryophyllidae Based on Comparative rbcL Sequences | [
"Plant Science",
"Genetics",
"Ecology, Evolution, Behavior and Systematics"
] | ||
Quarantine Maze, Part Two | [
"Visual Arts and Performing Arts",
"Cultural Studies"
] | ||
Locus of Control as a Multidimensional Personality Correlate of Political Involvement | [
"Education",
"Business, Management and Accounting (miscellaneous)"
] | ||
Effect of absorbing impurities on explosive initiation by laser light | [
"Energy Engineering and Power Technology",
"Fuel Technology"
] | ||
Report from Accident and Emergency departments | [
"Psychiatry and Mental Health"
] | ||
Work of the All-Union Interbranch Hydromechanization Section during 1976 | [
"Energy Engineering and Power Technology",
"Geotechnical Engineering and Engineering Geology",
"Ocean Engineering",
"Water Science and Technology"
] | ||
Élus aquitains et économie régionale sous la IIIe République | Parlement[s], Revue d'histoire politique | [
"Political Science and International Relations",
"Sociology and Political Science",
"History"
] | |
Synthesis of nanocrystalline Ba(CoxZn1−x)2Fe16O27 by sol–gel auto-combustion method | [
"Materials Chemistry",
"Metals and Alloys",
"Mechanical Engineering",
"Mechanics of Materials"
] | ||
Assessment of Gap between Knowledge and Practices among Type 2 Diabetes Mellitus Patients at a Tertiary-Care Hospital in Bangladesh | Newly diagnosed type 2 diabetes (T2 DM) patients who do not receive diabetes education (DE) have average knowledge on DM, and their practices about diabetes need to be improved. This prompted us to evaluate what happens when old diagnosed patients receive DE. The study therefore assessed the association between knowledge and practices in terms of Hemoglobin A1c (HbA1c), body mass index (BMI), and waist circumference (WC) among 500 diagnosed T2 DM using a cross-sectional design. An interviewer-administered questionnaire was used for assessing their knowledge. The mean knowledge score of the patients was 15.29 ± 3.6. A significant negative association was found between the knowledge score and the HbA1c level. Age was positively associated with HbA1c and WC. Duration of DM was positively and education was negatively associated with HbA1c. Gender was negatively associated with BMI while income was positively associated with BMI and WC. All the associations were significant. The diagnosed T2 DM patients are deficient of sufficient knowledge; the knowledge score and HbA1c have a significant negative relationship, not other actions. The risk factors for the patients’ outcome include old age, female gender, years of education, economic status, and duration of DM. | Advances in Public Health | [
"Public Health, Environmental and Occupational Health"
] |
Progress and prospects: RNA-based therapies for treatment of HIV infection | [
"Genetics",
"Molecular Biology",
"Molecular Medicine"
] | ||
Issue Highlights—November 2021 | [
"Cell Biology",
"Histology",
"Pathology and Forensic Medicine"
] | ||
A study of secondary cutaneous amyloidosis in basal cell carcinoma in Chinese patients: lack of correlation with bcl-2 or p53 protein expression | [
"Dermatology"
] | ||
Influence of hydrogen on room temperature recrystallisation of electrodeposited Cu films: thermal desorption spectroscopy | [
"Metals and Alloys",
"Surfaces, Coatings and Films",
"Surfaces and Interfaces",
"Mechanics of Materials",
"Condensed Matter Physics"
] | ||
Frontmatter | at - Automatisierungstechnik | [
"Electrical and Electronic Engineering",
"Computer Science Applications",
"Control and Systems Engineering"
] | |
The Development of Children's Graphic Representations of the Large-Scale Environment | [
"Education"
] | ||
Synthèse et stéréochimie d'un organosilane asymétrique bifonctionnel. Préparation de nouveaux composés organosiliciés optiquiment actifs | [
"Materials Chemistry",
"Inorganic Chemistry",
"Organic Chemistry",
"Physical and Theoretical Chemistry",
"Biochemistry"
] | ||
Microscale Hybrid Additive Manufacturing of Ultra‐Fine, Embedded Cu/Ag(shell)–P4VP(core) Grid for Flexible Transparent Electrodes | [
"Industrial and Manufacturing Engineering",
"Mechanics of Materials"
] | ||
Integration of motion information during binocular rivalry | [
"Sensory Systems",
"Ophthalmology"
] | ||
Can Sleep and Wakefulness Be Distinguished in Children by Cardiorespiratory and Videotape Recordings? | [
"Cardiology and Cardiovascular Medicine",
"Critical Care and Intensive Care Medicine",
"Pulmonary and Respiratory Medicine"
] | ||
Porous reduced graphene oxides derived by selective removal and formation of oxygen functional groups and their electrochemical capacitances | [
"Applied Mathematics",
"Industrial and Manufacturing Engineering"
] | ||
Defining Borderline Resectable Pancreatic Cancer: Emerging Consensus for an Old Challenge | [
"Oncology"
] | ||
Synthesis of a Novel 2,5-Dipropylhydroquinone-Bridged Ladder-Like Polymethylsiloxane Using a Hydroquinone H-Bonding Self-Assembling Template | [
"Materials Chemistry",
"Polymers and Plastics",
"Organic Chemistry"
] | ||
Perspective on robotic surgery and its role in head and neck cancers | [
"Radiology, Nuclear Medicine and Imaging",
"Oncology"
] | ||
Abstract: Wetumpka Melange, A New Stratigraphic Unit in Alabama | [
"Earth and Planetary Sciences (miscellaneous)",
"Geochemistry and Petrology",
"Geology",
"Energy Engineering and Power Technology",
"Fuel Technology"
] | ||
N-terminal-pro-brain natriuretic peptide as a haemodynamic marker in idiopathic pulmonary arterial hypertension | [
"Pulmonary and Respiratory Medicine"
] | ||
Heterogeneous effects of cholecystokinin on neuronal response properties in deep layers of rat barrel cortex | [
"Pharmacology (medical)",
"Biological Psychiatry",
"Psychiatry and Mental Health",
"Neurology (clinical)",
"Neurology",
"Pharmacology"
] | ||
Patients’ Perspectives on Wait Times and the Referral-Consultation Process While Attending a Tertiary Diabetes and Endocrinology Centre: Is Econsultation an Acceptable Option? | [
"Endocrinology",
"Endocrinology, Diabetes and Metabolism",
"Internal Medicine"
] | ||
Characteristics of landslide path dependency revealed through multiple resolution landslide inventories in the Nepal Himalaya | Geomorphology | [
"Earth-Surface Processes"
] | |
Editorial Board | [
"Space and Planetary Science",
"Earth and Planetary Sciences (miscellaneous)",
"Geochemistry and Petrology",
"Geophysics"
] | ||
Static and dynamic characterization of metal hydride tanks for energy management applications | [
"Renewable Energy, Sustainability and the Environment"
] | ||
Extraneural Metastasis of a Pineal Tumor | [
"Neurology (clinical)",
"Neurology"
] | ||
Appropriateness of coronary revascularization for patients with chronic stable angina or following an acute myocardial infarction: multinational versus Dutch criteria | [
"Public Health, Environmental and Occupational Health",
"Health Policy"
] | ||
Effects of COVID-19 on Cryptocurrency and Emerging Market Connectedness: Empirical Evidence from Quantile, Frequency, and Lasso Networks | [
"Industrial and Manufacturing Engineering",
"Polymers and Plastics",
"History",
"Business and International Management"
] | ||
The therapeutic power of poetry in Ian McEwan’s Saturday and The Children Act | Journal of Poetry Therapy | [
"Clinical Psychology",
"Rehabilitation"
] | |
Characterization of the Lipid Profile in Dementia and Depression in the Elderly | The purpose of the study was to examine the association of plasma lipid concentrations with changes in cognitive function and depressive states in elderly Greek individuals. The study population consisted of 3 groups: A) 37 subjects with dementia, B) 33 subjects with depression, and C) 33 controls. All individuals were screened with the Mini-Mental State Examination (MMSE), the Geriatric Depression Scale (GDS), and an evaluation of their psychiatric state. Lipid profile was assessed in all subjects, and the results were statistically evaluated at P | Journal of Geriatric Psychiatry and Neurology | [
"Psychiatry and Mental Health",
"Geriatrics and Gerontology",
"Neurology (clinical)"
] |
Triton Field Trials: Promoting Consistent Environmental Monitoring Methodologies for Marine Energy Sites | Uncertainty surrounding the potential environmental impacts of marine energy (ME) has resulted in extensive and expensive environmental monitoring requirements for ME deployments. Recently, there have been more ME deployments and associated environmental data collection efforts, but no standardized methodologies for data collection. This hinders the use of previously collected data to inform new ME project permitting efforts. Triton Field Trials (TFiT), created at the Pacific Northwest National Laboratory by the United States (U.S.) Department of Energy, explores ways to promote more consistent environmental data collection and enable data transferability across ME device types and locations. Documents from 118 previous ME projects or ME-related research studies in the U.S. and internationally were reviewed to identify the highest priority stressor–receptor relationships to be investigated and the technologies and methodologies used to address them. Thirteen potential field sites were assessed to determine suitable locations for testing the performance of relevant monitoring technologies. This introductory paper provides an overview of how priority research areas and associated promising technologies were identified as well as how testing locations were identified for TFiT activities. Through these scoping efforts, TFiT focused on four activity areas: collision risk, underwater noise, electromagnetic fields, and changes in habitat. Technologies and methodologies were tested at field sites in Alaska, Washington, California, and New Hampshire. Detailed information on the effectiveness of the identified methodologies and specific recommendations for each of the four focus areas are included in the companion papers in this Special Issue. | Journal of Marine Science and Engineering | [
"Ocean Engineering",
"Water Science and Technology",
"Civil and Structural Engineering"
] |
Calendar | [
"Biophysics"
] | ||
Phenothiazines suppress proliferation and induce apoptosis in cultured leukemic cells without any influence on the viability of normal lymphocytes | [
"Pharmacology (medical)",
"Cancer Research",
"Pharmacology",
"Toxicology",
"Oncology"
] | ||
Lawrence O. Gostin and Zita Lazzarini Human Rights and Public Health in the AIDS Pandemic | AbstractNo Abstract | [
"Law",
"Health Policy"
] | |
Carcinoid Tumors: Past, Present, and Future | [
"Oncology",
"Surgery"
] | ||
Abstract 10646: The Use of Beta Blockers and Renin Angiotensin System Inhibitors Among Patients with Concurrent HFrEF and Alzheimer’s Disease and Related Dementias (ADRD) | Introduction: Recent data suggests that patients with concurrent HFrEF and ADRD (HF+ADRD) have markedly higher mortality than HFrEF patients without ADRD. One of the proposed mechanisms for this is a lower rate of guideline directed medical therapy (GDMT) use in the HF+ADRD population. The aim of this study is to determine the change in GDMT use before and after HFrEF hospitalization for patients with HF+ADRD. Methods: We used 100% Medicare Parts A and B and a random 40% sample of Part D to create a cohort of 397,680 fee-for-service beneficiaries with ≥1 hospitalization for HFrEF between 2012 and 2018. We used previously validated ICD-9/10 codes to define ADRD. We created 4 exposure groups for both evidenced-based beta-blockers (BB) and renin angiotensin system inhibitors (RASI): “continued” (on drug before and after hospitalization); “initiated” (not on before, but on after); “discontinued” (on before, but not after) and “never started” (not on before or after). Results: Rates of BB continuation (42% vs. 37%, pTable 1 ). Rates of BB discontinuation (13% vs. 10%, p Conclusions: Rates of BB/RASI continuation and initiation are higher among HFrEF patients without ADRD while rates of BB/RASI discontinuation and never starting are higher among HF+ADRD patients. Additional work is needed to understand why GDMT use is lower in patients with HF+ADRD and to determine whether, in this population, there are adverse outcomes associated with failing to receive GDMT, such as increased HFrEF symptoms, hospital admissions, and mortality. | [
"Physiology (medical)",
"Cardiology and Cardiovascular Medicine"
] | |
Bioactive nanomembranes of semiconductor polythiophene and thermoplastic polyurethane: thermal, nanostructural and nanomechanical properties | [
"Organic Chemistry",
"Polymers and Plastics",
"Biochemistry",
"Bioengineering"
] | ||
The temperature of the sea-surface in the region of the Aegean and its relation to air temperature | [
"Atmospheric Science"
] | ||
BSAVA INews | [
"Small Animals"
] | ||
A Review of Live Survey Application: SurveyMonkey and SurveyGizmo | Live survey application is being used to get opinion from others. There are several types of live survey monkey that currently popular such as SurveyMonkey and Survey Gizmo. These live survey application will be compared in several types of features to identify which is suitable for education purpose. The comparison will be on the advantage and disadvantage of both applications, the security issues and solution on how to solve the issues. Three (3) phases involve in the research methodology such as searching, identify and the result of the comparison. The output of this paper is a comparison table that can be used for educational purpose. | [
"Information Systems and Management",
"Statistics, Probability and Uncertainty"
] | |
E-CADHERIN IMMUNOSTAINING OF BLADDER TRANSITIONAL CELL CARCINOMA, CARCINOMA IN SITU AND LYMPH NODE METASTASES WITH LONG-TERM FOLLOWUP | [
"Urology"
] | ||
Predicting Peculiar Interstellar Extinction from Gaseous Abundances: Erratum | [
"Space and Planetary Science",
"Astronomy and Astrophysics"
] | ||
The MFMU cesarean registry: Induction of labor following one prior cesarean | American Journal of Obstetrics and Gynecology | [
"Obstetrics and Gynecology"
] | |
Numerical Modeling of Sperm Swimming | Due to rising human infertility, sperm motility has been an important subject. Among the hundreds of millions of sperms on the journey up the oviducts, only a few excellent travelers will reach the eggs. This journey is affected by many factors, some of which include sperm quality, sperm density, fluid rheology and chemotaxis. In addition, the sperm swimming through different body tracks and fluids involves complex sperm flagellar, complex fluid environment, and multi-sperm and sperm-wall interactions. Therefore, this topic has generated substantial research interest. In this paper, we present a review of computational studies on sperm swimming from an engineering perspective with focus on both simplified theoretical methods and fluid–structure interaction methods. Several open issues in this field are highlighted. | [
"Fluid Flow and Transfer Processes",
"Mechanical Engineering",
"Condensed Matter Physics"
] | |
Carbamic Esters from Urea | Journal of the American Chemical Society | [
"Colloid and Surface Chemistry",
"Biochemistry",
"Catalysis"
] | |
T/B-cell interactions are more transient in response to weak stimuli in SLE-prone mice | European Journal of Immunology | [
"Immunology",
"Immunology and Allergy"
] | |
The Horror and the Pleasure of Un-English Fiction: Ida von Hahn-Hahn and Fanny Lewald in England | [
"Literature and Literary Theory",
"Cultural Studies"
] | ||
M.P.3.08 Resistance exercise training in mitochondrial myopathy due to single, large-scale deletions: Implications for therapy | [
"Genetics (clinical)",
"Neurology (clinical)",
"Neurology",
"Pediatrics, Perinatology and Child Health"
] | ||
Markers of Nerve Tissue Injury in the Cerebrospinal Fluid in Patients With Lumbar Disc Herniation and Sciatica | [
"Neurology (clinical)",
"Orthopedics and Sports Medicine"
] | ||
Polarization-independent frequency conversion for quantum optical communication | [
"Atomic and Molecular Physics, and Optics",
"Statistical and Nonlinear Physics"
] | ||
A Low-Molecular-Mass GTP-Binding Protein in the Cytosol of Germinated Wheat Embryos | [
"Biochemistry"
] | ||
Electronic spectra of some isocyanide complexes | [
"Materials Chemistry",
"Inorganic Chemistry",
"Physical and Theoretical Chemistry"
] | ||
‘Brightening the dreary existence of the Irish peasant’: Cinema transforms leisure in provincial Ireland | [
"History",
"Visual Arts and Performing Arts",
"Cultural Studies"
] | ||
Intra-Facility Acquisition of Methicillin-Resistant Staphylococcus aureus (MRSA) in Southern Wisconsin Skilled Nursing Facilities | [
"Infectious Diseases",
"Oncology"
] | ||
Plasmonic properties of Fischer's patterns: polarization effects | Physical Chemistry Chemical Physics | [
"Physical and Theoretical Chemistry"
] | |
Synthesis and properties of symmetrical N,N'-Bis(R-adamantan-1-yl)ureas as target-oriented soluble epoxide hydrolase (sEH) inhibitors | [
"Organic Chemistry"
] | ||
Governing Social Inclusion: Europeanization through Policy Coordination, by K. Armstrong (New York: Oxford University Press, 2010, ISBN 9870199278374); xvi+332 pp., £50.00 hb. Framing Europe: The Policy Shaping Strategies of the European Commission, by M. | [
"Political Science and International Relations",
"Economics and Econometrics",
"Business and International Management"
] | ||
Exergy investigation of three ideal regeneration methods for liquid desiccant: Thermal air, mechanical vapor recompression and electrodialysis regeneration | [
"Electrical and Electronic Engineering",
"Mechanical Engineering",
"Building and Construction",
"Civil and Structural Engineering"
] | ||
Influencia del sexo en el abordaje de la enfermedad cardiovascular en atención primaria | [
"Family Practice"
] | ||
Optical anisotropy of diphenylmethane type residues in polymers | [
"Materials Chemistry",
"Polymers and Plastics",
"Condensed Matter Physics"
] | ||
Should a Medical Center Deny Employment to a Physician Because He Smokes Tobacco Products? | [
"Cardiology and Cardiovascular Medicine",
"Pulmonary and Respiratory Medicine",
"Surgery"
] | ||
Joan M. Petersen. The Dialogues of Gregory the Great in Their Late Antique Cultural Background. (Studies and Texts, number 69.) Toronto: Pontifical Institute of Mediaeval Studies; distributed by E. J. Brill, Leiden. 1984. Pp. xxiv, 227. f. 51 | [
"Museology",
"Archeology",
"History"
] | ||
Two Distinguished Awards for MRD Founding Editor Jack D. Ives | [
"Development",
"Environmental Chemistry"
] | ||
Ambient air particulate matter: A cause of airway and systemic disease | Toxicology Letters | [
"Toxicology"
] | |
A free-space method for measurement of dielectric constants and loss tangents at microwave frequencies | IEEE Transactions on Instrumentation and Measurement | [
"Electrical and Electronic Engineering",
"Instrumentation"
] | |
Planet (254).Augusta | [
"Space and Planetary Science",
"Astronomy and Astrophysics"
] | ||
Electrical activity of human colonic smooth muscle in vitro. | [
"Physiology"
] | ||
One-Pot Synthesis of Thieno[2,3-b]pyridine and Pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine Derivatives | Russian Journal of Organic Chemistry | [
"Organic Chemistry"
] | |
A new era for castrate resistant prostate cancer: A treatment review and update | Purpose: The purpose of this review article is to present the current treatment options for castrate resistant prostate cancer in addition to the recently approved agents and their role in treatment. Summary: The biology of prostate cancer and the data supporting the use of traditional chemotherapeutic options in castrate resistant prostate cancer are reviewed. The newly approved agents, sipuleucel-T, cabazitaxel, and abiraterone, are presented as well. The studies that led to the approval of these three agents are discussed in this article as well as their current and potential roles in the treatment of castrate resistant prostate cancer. Conclusion: New mechanisms, drugs, and clinically relevant molecular targets show survival advantage and are new options available for patients after traditional chemotherapy. The roles of these new agents have yet to be further clarified in future studies. | [
"Pharmacology (medical)",
"Oncology"
] | |
Multi-Level Reversible Data Anonymization via Compressive Sensing and Data Hiding | [
"Computer Networks and Communications",
"Safety, Risk, Reliability and Quality"
] | ||
Recording the Brain at Work: The Visible, the Readable, and the Invisible in Electroencephalography | Journal of the History of the Neurosciences | [
"History and Philosophy of Science",
"Neurology (clinical)"
] | |
Femoral compression device | [
"LPN and LVN",
"Advanced and Specialized Nursing",
"Assessment and Diagnosis",
"Critical Care Nursing",
"Emergency Nursing"
] | ||
Antepartum screening in the office-based practice: Findings from the Collaborative Ambulatory Research Network | [
"Obstetrics and Gynecology",
"Pediatrics, Perinatology and Child Health"
] | ||
New perturbation bounds of partitioned generalized Hermitian eigenvalue problem | [
"Applied Mathematics",
"Computational Mathematics"
] | ||
Abstract P2-26-10: Statins exhibit an anti-tumor effect by attenuating PD-L1 in breast cancer cells and macrophages and reducing breast tumor progression in xenograft mouse model | Abstract Background: Statins were suggested for repurposed drugs, having multifaceted effects which include anti-tumor activities by modulating the immune response. Here, we aimed to demonstrate the effect of statins on programmed death-ligand 1 (PD-L1) expression in triple-negative breast cancer (TNBC) cells. Methods: Thirteen human TNBC cell lines, mouse macrophage cell line (RAW 264.7), cholesterol and 27-hydroxycholesterol, and clinically approved lovastatin and simvastatin were used. Flow cytometry, Annexin V/propidium iodide assay, western blot, qRT-PCR, transwell migration assay, and immunohistochemistry were employed. A co-culture of macrophages with various breast cancer cells was performed. An orthotopic breast tumor mouse model and metastasis model by injection of GFP-tagged MDA-MB-231 cells into mammary gland fat pad and the tail vein injection were produced. In tumor model mice, lovastatin(10mg/kg) was daily injected intraperitoneally. In vivo fluorescent imaging was used to identify primary tumor development and lung metastasis. Results: Among thirteen TNBC cell lines, MDA-MB-231, HCC38, and HCC70 highly expressed endogenous/constitutive PD-L1. Statins reduced PD-L1 expression and exerted anti-proliferative and apoptotic effects in MDA-MB-231, HCC38, HCC70, and Raw264.7 in a dose- and time-dependent manner (p< 0.05). Meanwhile, statins increased the expression of PD-L1 in Hs578T and MDA-MB-468. STAT3 phosphorylation was inhibited in MDA-MB-231 and HCC70, but not in Hs578T, while AKT phosphorylation was reduced in MDA-MB-231, HCC70, Hs578T, and MDA-MB-468 when statins were treated. The migration of MDA-MB-231 and Raw264.7 in statin-treated conditioned media was decreased (p< 0.05). Cholesterol and 27-hydroxy cholesterol did not restore PD-L1 expression in statin-treated MDA-MB-231. Statins suppressed the expression of M2 markers (PD-L1, CD206, YM-1, Fizz1, arginase-1) in RAW26437 stimulated by a conditioned medium of MDA-MB-231. Lovastatin suppressed the primary tumor growth and metastasis in xenograft tumor mice. Conclusions: Our findings show that statins have an anti-tumor effect, which kills breast cancer cells and triggers macrophage reprogramming by reducing PD-L1 expression, impairing the AKT, ERK, and STAT3 signal pathways, and decreasing M2 markers. Further study is needed to investigate an in-depth molecular mechanism study by which statins regulate PD-L1 expression in TNBC and to confirm the safe and effective use of statins as adjuvant therapy in TNBC. Citation Format: Sangeun Lee, Hoe Suk Kim, So-Hyun Yoon, Seungyeon Ryu, Moonjou Baek, A Young Park, Han-Byoel Lee, Wonshik Han. Statins exhibit an anti-tumor effect by attenuating PD-L1 in breast cancer cells and macrophages and reducing breast tumor progression in xenograft mouse model [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P2-26-10. | Cancer Research | [
"Cancer Research",
"Oncology"
] |
Lipoblastoma mediastínico en pediatría | Objetivo: Describir dos casos de lipoblastoma mediastínico, patología de baja incidencia y poco conocida, siendo aún más infrecuente en mediastino, sin haber reportes descritos en nuestro país.Casos Clínicos: 2 pacientes, ambos de sexo masculino, menores de 3 años, en los que se encontró como hallazgo incidental una masa mediastínica en una radiografía de tórax. El estudio se complementó con una tomografía computada y en uno de los pacientes con una biopsia toracoscópica. En ambos se logró extirpación completa de la lesión vía toracotomía, siendo apoyado vía toracoscópica previa a la extracción de la lesión en uno de ellos. Uno de los pacientes evolucionó con Síndrome de Claude Bernard Horner el cual resolvió de manera espontánea luego de dos años y el segundo caso no presentó complicaciones.Conclusiones: el lipoblastoma mediastínico es una patología muy poco frecuente, las descripciones de la literatura se asemejan a los casos expuestos en este artículo, concluyendo que presentan un patrón muy similar entre ellos. Teniendo un pronóstico favorable si se logra la resección completa y siendo fundamental diferenciarlo de sus diagnósticos diferenciales para descartar malignidad. | Revista Chilena de Pediatría | [
"Pediatrics, Perinatology and Child Health"
] |
Hematogenous origin of the inflammatory response in acute poliomyelitis | [
"Neurology (clinical)",
"Neurology"
] | ||
Modulating Toll-like receptor signaling as a novel antiinfective approach | Drug News & Perspectives | [
"Drug Discovery",
"Pharmacology"
] | |
Fault Tolerance Analysis of Five-Level Neutral-Point-Clamped Inverters under Clamping Diode Open-Circuit Failure | Multilevel inverters are increasingly used in industrial applications in which service continuity is crucial. This paper presents an original approach to ensure the fault-tolerant operation of neutral-point-clamped (NPC) inverters in the case of an open-circuit fault event in a clamping diode, which is rarely investigated in the conducted research work. The proposed fault-tolerant strategy meets the following criteria: restoring rated output voltage and current during post-fault operation, realizing fault-tolerant operation without additional components, maintaining rated total harmonic distortion (THD) during fault-tolerant operation, and fast transition between faulty operation and remedial operation. In the proposed approach, prior to applying the appropriate remedial action, identification of the defective clamping diode is required. In this respect, a very fast and simple logic-based fault diagnosis is presented whose implementation does not need any additional components and external circuit. Moreover, it does not require any component modeling and complicated calculations. The proposed strategy is validated by simulation and experimentation. | [
"Electrical and Electronic Engineering",
"Computer Networks and Communications",
"Hardware and Architecture",
"Signal Processing",
"Control and Systems Engineering"
] | |
Testosteronmangel und metabolisches Syndrom | [
"Urology"
] | ||
Some hydrodynamic aspects of 3-phase inverse fluidized bed | [
"Condensed Matter Physics"
] | ||
Closure to “ Load Sequence and Structure‐Foundation Interaction ” by Peter T. Brown and Si K. R. Yu (March, 1986, Vol. 112, No. 3) | [
"Mechanical Engineering",
"Mechanics of Materials",
"Building and Construction",
"Civil and Structural Engineering"
] | ||
Abdominal Obesity Is Characterized by Higher Pulse Pressure: Possible Role of Free Triiodothyronine | [
"Endocrinology, Diabetes and Metabolism"
] |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.