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Clinical efficacy of immunochemotherapy with rituximab , fludarabine and mitoxantrone followed by 2-monthly rituximab maintenance was evaluated in 29 patients with previously untreated follicular lymphoma in a prospective phase II trial ( AGMT-NHL9 ) . | [{'class': 'POS', 'spans': ['rituximab', 'fludarabine', 'mitoxantrone'], 'is_context_needed': True}] |
Palliative chemotherapy with carboplatin and etoposide produced a minimal response . | [{'class': 'NEG', 'spans': ['carboplatin', 'etoposide'], 'is_context_needed': False}] |
In vitro susceptibilities of ocular Bacillus cereus isolates to clindamycin , gentamicin , and vancomycin alone or in combination . | [{'class': 'COMB', 'spans': ['clindamycin', 'gentamicin', 'vancomycin'], 'is_context_needed': True}] |
Most ( ≥ 75 % ) patients received ESHAP ( etoposide , methylprednisolone , cytarabine , cisplatin ) or DHAP ( cisplatin , cytosine arabinoside , dexamethasone ) as salvage chemotherapy . | [{'class': 'COMB', 'spans': ['etoposide', 'methylprednisolone', 'cytarabine', 'cisplatin'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [4, 6], 'is_context_needed': True}] |
Patients treated on CCG-3881 ( n = 116 ) received four-drug chemotherapy for 9 months ( cisplatin , cyclophosphamide , doxorubicin , and etoposide ) , with surgery and local radiation to residual disease . | [{'class': 'POS', 'spans': ['cisplatin', 'cyclophosphamide', 'doxorubicin', 'etoposide'], 'is_context_needed': True}] |
These data suggest that weekly docetaxel plus carboplatin may be an important therapeutic second-line treatment option for patients with DRPC . | [{'class': 'POS', 'spans': ['docetaxel', 'carboplatin'], 'is_context_needed': False}] |
The recommended phase II dose is bortezomib 1.0 mg/m on days 1 , 4 , 8 , and 11 plus docetaxel 75 mg/m on day 1 , cycled every 21 days . | [{'class': 'POS', 'spans': ['bortezomib', 'docetaxel'], 'is_context_needed': False}] |
Budesonide/formoterol pMDI affords equivalent formoterol-related bronchodilatory effects versus formoterol DPI at formoterol doses of 4.5 , 9 , and 18 microg , indicating that practitioners can expect and patients will experience similar bronchodilation from the same dose of formoterol whether it is delivered as monotherapy via a DPI or as combination therapy with budesonide via one pMDI . | [{'class': 'COMB', 'spans': ['formoterol', 'budesonide'], 'is_context_needed': True}] |
A 29-year-old white man with recurrent Hodgkin 's disease received doxorubicin , bleomycin , vinblastine , and dacarbazine ( ABVD ) chemotherapy once every two weeks for 12 cycles . | [{'class': 'COMB', 'spans': ['doxorubicin', 'bleomycin', 'vinblastine', 'dacarbazine'], 'is_context_needed': True}] |
This review focuses on the activity and toxicity of the time-limited combination of venetoclax plus rituximab for the treatment of relapsed or refractory CLL , presenting clinical trial results and data from correlative studies , with the aim of highlighting the strengths of this treatment approach and discuss weaknesses and possible areas of improvement . | [{'class': 'POS', 'spans': ['venetoclax', 'rituximab'], 'is_context_needed': True}] |
Advanced male breast cancer treatment with the LH-RH analogue buserelin alone or in combination with the antiandrogen flutamide . | [{'class': 'COMB', 'spans': ['buserelin', 'flutamide'], 'is_context_needed': True}] |
In an effort to improve its efficacy , mitoxantrone was tested for synergistic activity with cidofovir . | [{'class': 'POS', 'spans': ['mitoxantrone', 'cidofovir'], 'is_context_needed': True}] |
In the current study , we investigated the hypothesis that targeting of P-gp by diltiazem can enhance the cytotoxicity of gemcitabine and 5-FU against human pancreatic cancer cells . | [{'class': 'POS', 'spans': ['diltiazem', 'gemcitabine'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': True}] |
In all , 171 patients with histologically verified non-small cell lung carcinoma were treated with ifosfamide 2.0 g/m2 on days 1 - 5 in combination with ( 91 patients ) etoposide 120 mg/m2 on day 1 . | [{'class': 'POS', 'spans': ['ifosfamide', 'etoposide'], 'is_context_needed': True}] |
In the large-scale trials carried out in Tanganyika and described in this paper , such a combination , containing amodiaquine for schizontocidal effect and primaquine as a gametocytocide , was administered to three distinct population groups of more than 5000 at differing intervals of time , in order to determine the ability of this combination to interfere with transmission in the absence of other malaria control measures . | [{'class': 'COMB', 'spans': ['amodiaquine', 'primaquine'], 'is_context_needed': True}] |
In transplant eligible patients , induction therapy consists of bortezomib , lenalidomide , dexamethasone ( VRd ) given for approximately 3 - 4 cycles followed by autologous stem cell transplantation ( ASCT ) . | [{'class': 'POS', 'spans': ['bortezomib', 'lenalidomide', 'dexamethasone'], 'is_context_needed': True}] |
Genistein combined polysaccharide enhances activity of docetaxel , bicalutamide and Src kinase inhibition in androgen-dependent and independent prostate cancer cell lines . | [{'class': 'POS', 'spans': ['Genistein', 'docetaxel'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}] |
Combination therapy with bosentan and sildenafil was effective for this case of refractory PAH associated with fibrotic lung in systemic sclerosis . | [{'class': 'POS', 'spans': ['bosentan', 'sildenafil'], 'is_context_needed': False}] |
Analysis of 52 eyes with high-risk retinoblastoma managed with postenucleation adjuvant chemotherapy using vincristine sulfate , etoposide phosphate , and carboplatin showed no evidence of systemic metastasis in any case during a mean ( range ) follow-up of 66 ( 12 - 202 ) months . | [{'class': 'POS', 'spans': ['vincristine', 'etoposide', 'carboplatin'], 'is_context_needed': True}] |
Clinical and cost-effectiveness of capecitabine and tegafur with uracil for the treatment of metastatic colorectal cancer : systematic review and economic evaluation . | [{'class': 'COMB', 'spans': ['capecitabine', 'tegafur'], 'is_context_needed': True}] |
Cost-effectiveness of cetuximab , cetuximab plus irinotecan , and panitumumab for third and further lines of treatment for KRAS wild-type patients with metastatic colorectal cancer . | [{'class': 'POS', 'spans': ['cetuximab', 'irinotecan'], 'is_context_needed': True}] |
This multicenter pilot study assessed the feasibility and efficacy of a time-intensified bleomycin , etoposide , doxorubicin , cyclophosphamide , vincristine , procarbazine , and prednisone ( BEACOPP ) regimen given in 14-day intervals ( BEACOPP-14 ) with granulocyte colony-stimulating factor ( G-CSF ) support in advanced Hodgkin 's lymphoma . | [{'class': 'POS', 'spans': ['bleomycin', 'etoposide', 'doxorubicin', 'cyclophosphamide', 'vincristine', 'procarbazine', 'prednisone'], 'is_context_needed': True}] |
Safety and efficacy of daclatasvir and asunaprevir in hepatitis C virus-infected patients with renal impairment . | [{'class': 'POS', 'spans': ['daclatasvir', 'asunaprevir'], 'is_context_needed': True}] |
We report the results of replacement of steroids by azathioprine ( AZA ) in 25 primary cadaveric renal transplant recipients initially treated with CsA and methylprednisolone ( MP ) . | [{'class': 'POS', 'spans': ['azathioprine', 'CsA'], 'is_context_needed': True}] |
One group of patients was treated with oral mefloquine ( 750 mg ) and artemether ( 600 mg by injection , 200 mg initially and 100 mg every 12 h ) . | [{'class': 'POS', 'spans': ['mefloquine', 'artemether'], 'is_context_needed': True}] |
The role of irinotecan and oxaliplatin in the treatment of advanced colorectal cancer . | [{'class': 'POS', 'spans': ['irinotecan', 'oxaliplatin'], 'is_context_needed': True}] |
In both cases , chemotherapy comprising rituximab + dose-adjusted EPOCH regimen ( etoposide , prednisone , vincristine , cyclophosphamide and doxorubicin ) was administered . | [{'class': 'POS', 'spans': ['rituximab', 'etoposide', 'prednisone', 'vincristine', 'cyclophosphamide', 'doxorubicin'], 'is_context_needed': True}] |
Bleeding prophylaxis included combinations of plasma-derived factor ( VWD ) or recombinant factor ( haemophilia A and haemophilia B ) , desmopressin and/or tranexamic acid . | [{'class': 'POS', 'spans': ['desmopressin', 'tranexamic'], 'is_context_needed': True}] |
Although progression-free survival with the bevacizumab plus capecitabine combination is inferior to that noted with bevacizumab plus paclitaxel , we suggest that physicians should consider possible predictive risk factors for overall survival , individual 's treatment priorities , and the differing safety profiles . | [{'class': 'COMB', 'spans': ['bevacizumab', 'capecitabine'], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': False}] |
The combination of ixabepilone and bevacizumab was well tolerated , with modest activity in second - or later-line mRCC , but it is not recommended as a therapy without further clinical development . | [{'class': 'COMB', 'spans': ['ixabepilone', 'bevacizumab'], 'is_context_needed': True}] |
Eligible patients with unresectable MPM , without disease progression following 4 to 6 cycles of pemetrexed and platinum were randomized 1:1 to observation or continuation of pemetrexed until progression , stratified by number of cycles ( < 6 or 6 ) , cis- or carboplatin containing regimen , and histology . | [{'class': 'COMB', 'spans': ['pemetrexed', 'platinum'], 'is_context_needed': True}] |
A Phase II trial reported a median OS duration of 8.6 months for patients receiving cetuximab plus irinotecan , plus a median time to progression of 4.1 months , a tumour response rate of 22.9 % and suggested that treatment with cetuximab in combination with irinotecan is associated with significantly more adverse events ( any grade 3 or grade 4 adverse event ) than cetuximab monotherapy . | [{'class': 'COMB', 'spans': ['cetuximab', 'irinotecan'], 'is_context_needed': True}] |
Our results show meaningful activity of T-DM1 after front-line pertuzumab plus trastuzumab and a taxane , with about 27 % of patients having an objective response and 40 % of patients achieving durable disease control . | [{'class': 'POS', 'spans': ['pertuzumab', 'trastuzumab'], 'is_context_needed': False}] |
Dapagliflozin seemed to play a role in accelerating the patient 's urinary sodium excretion as well as reducing gross fluid retention despite the fact that her nephrotic condition was resistant to furosemide . | [{'class': 'POS', 'spans': ['Dapagliflozin', 'furosemide'], 'is_context_needed': True}] |
PA combination of goserelin and tamoxifen in patients with relapsed ovarian cancer can not be recommended as standard therapy , but may result in long-term survival in individual patients . | [{'class': 'COMB', 'spans': ['goserelin', 'tamoxifen'], 'is_context_needed': True}] |
In previous analyses of the MURANO study , fixed-duration venetoclax plus rituximab ( VenR ) resulted in improved progression-free survival ( PFS ) compared with bendamustine plus rituximab ( BR ) in patients with relapsed or refractory chronic lymphocytic leukemia ( CLL ) . | [{'class': 'POS', 'spans': ['venetoclax', 'rituximab'], 'is_context_needed': False}, {'class': 'COMB', 'spans': [2, 3], 'is_context_needed': True}] |
The aim of the present study was to determine whether a combination of atorvastatin and amlodipine causes sympathoinhibition via reduction of oxidative stress in the RVLM and improves cognitive dysfunction of hypertensive rats . | [{'class': 'POS', 'spans': ['atorvastatin', 'amlodipine'], 'is_context_needed': True}] |
Active treatment consisted of hydrochlorothiazide ( 25 - 50 mg/day ) plus triamterene ( 50 - 100 mg/day ) with the addition of alpha-methyldopa ( 0.5 - 2.0 g/day ) in one-third of the patients . | [{'class': 'POS', 'spans': ['hydrochlorothiazide', 'triamterene', 'alpha-methyldopa'], 'is_context_needed': True}] |
It is predicted that patients suffering from both VL and cardiac disorders ( atrial fibrillation ) may benefit if they are treated with warfarin in conjunction with first-line antileishmanial therapies such as miltefosine and AmBisome . | [{'class': 'COMB', 'spans': ['warfarin', 'miltefosine'], 'is_context_needed': True}] |
If concomitant therapy is absolutely necessary , the dose of digoxin should be halved prior to initiating dronedarone . | [{'class': 'COMB', 'spans': ['digoxin', 'dronedarone'], 'is_context_needed': True}] |
All patients received neoadjuvant chemotherapy with cyclophosphamide , doxorubicin , and fluorouracil , or cyclophosphamide , doxorubicin , vincristine , and prednisone . | [{'class': 'POS', 'spans': ['cyclophosphamide', 'doxorubicin', 'fluorouracil'], 'is_context_needed': True}, {'class': 'POS', 'spans': [3, 4, 5, 6], 'is_context_needed': True}] |
We analyzed 129 non-Hodgkin lymphoma patients who underwent AHSCT from 1996 to 2013 using the most common regimens : CBV ( cyclophosphamide , carmustine and etoposide ; n = 16 ) , BEAM ( carmustine , etoposide , cytarabine and melphalan ; n = 36 ) and BEAC ( carmustine , etoposide , cytarabine and cyclophosphamide ; n = 77 ) . | [{'class': 'POS', 'spans': ['cyclophosphamide', 'carmustine', 'etoposide'], 'is_context_needed': True}, {'class': 'POS', 'spans': [3, 4, 5, 6], 'is_context_needed': True}, {'class': 'POS', 'spans': [8, 9, 10, 7], 'is_context_needed': True}] |
Early Prostate-Specific Antigen ( PSA ) Change at Four Weeks of the First-Line Treatment Using Abiraterone and Enzalutamide Could Predict Early/Primary Resistance in Metastatic Castration-Resistant Prostate Cancer . | [{'class': 'POS', 'spans': ['Abiraterone', 'Enzalutamide'], 'is_context_needed': True}] |
Dexamethasone , cytarabine , ifosfamide , and cisplatin as salvage therapy in non-Hodgkin lymphoma . | [{'class': 'POS', 'spans': ['Dexamethasone', 'cytarabine', 'ifosfamide', 'cisplatin'], 'is_context_needed': True}] |
Cost-effectiveness of ribociclib plus letrozole | [{'class': 'POS', 'spans': ['ribociclib', 'letrozole'], 'is_context_needed': True}] |
We investigated whether lapatinib plus gemcitabine has synergistic or antagonistic effects on the pancreatic cancer cell lines MiaPaca-2 and PANC-1 . | [{'class': 'COMB', 'spans': ['lapatinib', 'gemcitabine'], 'is_context_needed': True}] |
The PANDORA trial has demonstrated that the combination of high dose pantoprazole with docetaxel is tolerable , but the clinical activity was not sufficient to warrant further testing . | [{'class': 'COMB', 'spans': ['pantoprazole', 'docetaxel'], 'is_context_needed': True}] |
Effective plasma levels of both saquinavir and lopinavir can be achieved by the co-administration of saquinavir soft-gel capsules and lopinavir/ritonavir . | [{'class': 'POS', 'spans': ['saquinavir', 'lopinavir'], 'is_context_needed': True}] |
In recent years several tyrosine kinase inhibitors targeting specific molecular pathways involved in its pathogenesis have been investigated , such as sorafenib , lenvatinib , and sunitinib . | [{'class': 'POS', 'spans': ['sorafenib', 'sunitinib'], 'is_context_needed': True}] |
The in vitro antibacterial activity of zidovudine alone and in combination with ciprofloxacin was investigated . | [{'class': 'POS', 'spans': ['zidovudine', 'ciprofloxacin'], 'is_context_needed': True}] |
This patient was a case of primary antiphospholipid antibody syndrome in which endothelial cell damage was located exclusively in the capillary lumens and pulse cyclophosphamide therapy in addition to prednisolone and anticoagulant was effective . | [{'class': 'POS', 'spans': ['cyclophosphamide', 'prednisolone'], 'is_context_needed': False}] |
Vancomycin and gentamicin were administered systemically just prior to surgery and streptomycin was added to the irrigating solution . | [{'class': 'POS', 'spans': ['Vancomycin', 'gentamicin', 'streptomycin'], 'is_context_needed': True}] |
We observed a synergistic cytotoxic effect for the combination of foretinib and lapatinib on the viability and proliferation of the examined melanoma cell lines . | [{'class': 'POS', 'spans': ['foretinib', 'lapatinib'], 'is_context_needed': False}] |
Following knockdown of ANXA2 in NB cell line SK-N-BE(2 ) using shRNA , we demonstrate enhanced drug sensitivity for doxorubicin ( 2.77-fold ) and etoposide ( 7.87-fold ) compared with control . | [{'class': 'POS', 'spans': ['doxorubicin', 'etoposide'], 'is_context_needed': False}] |
Combined therapy with amiodarone and carvedilol provided greatest reduction of sudden arrhythmic and total mortality . | [{'class': 'POS', 'spans': ['amiodarone', 'carvedilol'], 'is_context_needed': False}] |
Patients with progressive refractory NSCLC who had previously benefitted from erlotinib ( objective response or stable disease > 8weeks ) were randomized to receive treatment with either erlotinib and sorafenib ( 400 mg orally twice daily ) or sorafenib alone . | [{'class': 'NEG', 'spans': ['erlotinib', 'sorafenib'], 'is_context_needed': True}] |
In this challenging field , aflibercept offers a good option for oxaliplatin-refractory mCRC patients when combined with irinotecan and 5-fluorouracil irrespective of prior anti-angiogenic treatment . | [{'class': 'POS', 'spans': ['aflibercept', 'irinotecan', '5-fluorouracil'], 'is_context_needed': False}] |
The combination of 1-hour paclitaxel , carboplatin , and extended oral schedule etoposide is feasible and well tolerated at the doses administered in this phase II trial . | [{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin', 'etoposide'], 'is_context_needed': False}] |
In this regard , we have synthesized Pem-PEG-Gem , wherein pemetrexed ( Pem ) and gemcitabine ( Gem ) are conjugated to a heterobifunctional polyethylene glycol ( PEG ) polymer for the effective treatment of Non-Small Cell Lung Cancer ( NSCLC ) . | [{'class': 'POS', 'spans': ['pemetrexed', 'gemcitabine'], 'is_context_needed': True}] |
After the initiation of antimalarial treatment with artesunate and mefloquine , his clinical condition gradually improved . | [{'class': 'POS', 'spans': ['artesunate', 'mefloquine'], 'is_context_needed': False}] |
For those few patients who do not respond to first-line therapy , the combination of vinblastine , ifosfamide , and cisplatin is the most popular regimen for the subset of platinum-sensitive tumors . | [{'class': 'POS', 'spans': ['vinblastine', 'ifosfamide', 'cisplatin'], 'is_context_needed': True}] |
Patients received once-daily vandetanib ( planned dosing levels of 100 , 200 , and 300 mg ) with concomitant daily radiotherapy ( 1.8 Gy/d , 45 Gy total ) and chemotherapy , consisting of infusional 5-FU ( 225 mg/m/d over 96 h , weekly ) , paclitaxel ( 50 mg/m , days 1 , 8 , 15 , 22 , 29 ) and carboplatin ( AUC of 5 , days 1 , 29 ) . | [{'class': 'POS', 'spans': ['vandetanib', '5-FU', 'paclitaxel', 'carboplatin'], 'is_context_needed': True}] |
The calcium channel blocker verapamil has been previously shown to augment the chemosensitivity of pancreatic adenocarcinoma cell lines to doxorubicin by mechanisms other than changes in the intracellular accumulation , retention , or metabolism of doxorubicin . | [{'class': 'COMB', 'spans': ['verapamil', 'doxorubicin'], 'is_context_needed': True}] |
The results of a randomized phase II trial have demonstrated that the addition of cetuximab to irinotecan in patients with irinotecan-resistant tumors represents another active treatment option for these patients . | [{'class': 'POS', 'spans': ['cetuximab', 'irinotecan'], 'is_context_needed': False}] |
Normal heart rate and rhythm were then preserved temporarily with digoxin and flecainide . | [{'class': 'POS', 'spans': ['digoxin', 'flecainide'], 'is_context_needed': False}] |
A phase I/II and pharmacokinetic study of irinotecan in combination with capecitabine as first-line therapy for advanced colorectal cancer . | [{'class': 'POS', 'spans': ['irinotecan', 'capecitabine'], 'is_context_needed': True}] |
The purpose of this study was to determine whether combination therapy with vancomycin and TZP is associated with an incidence of AKI in pediatric patients higher than that in those on combination therapy with vancomycin and cefepime . | [{'class': 'NEG', 'spans': ['vancomycin', 'TZP'], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': True}] |
In patients who experience disease progression after etoposide , doxorubicin , cisplatin with mitotane ( EDP-M ) , gemcitabine and metronomic capecitabine , or the less used streptozotocin , represent a second-line chemotherapy option . | [{'class': 'POS', 'spans': ['gemcitabine', 'capecitabine'], 'is_context_needed': False}, {'class': 'POS', 'spans': [4, 6], 'is_context_needed': False}] |
We conclude that ropivacaine alone injected into the pterygomandibular region does not affect the cardiovascular system and that the addition of epinephrine has no beneficial effect . | [{'class': 'COMB', 'spans': ['ropivacaine', 'epinephrine'], 'is_context_needed': True}] |
The next broad-spectrum drug was ethionamide , followed by ansamycin , rifampin , capreomycin , kanamycin , streptomycin and ethambutol . | [{'class': 'COMB', 'spans': ['ethionamide', 'rifampin', 'capreomycin', 'kanamycin', 'streptomycin', 'ethambutol', 'ansamycin'], 'is_context_needed': True}] |
Phase I/II study of gefitinib and capecitabine in patients with colorectal cancer . | [{'class': 'POS', 'spans': ['gefitinib', 'capecitabine'], 'is_context_needed': True}] |
Both the BTK inhibitor ibrutinib and the BCL2 inhibitor venetoclax are active as monotherapy in the treatment of mantle-cell lymphoma . | [{'class': 'POS', 'spans': ['ibrutinib', 'venetoclax'], 'is_context_needed': True}] |
A group of 14 patients with small-cell lung cancer received a 1-h intravenous infusion of 2.0 or 3.0 g/m2 ifosfamide over 1 or 2 days in combination with 175 mg/m2 paclitaxel and carboplatin at AUC 6 . | [{'class': 'COMB', 'spans': ['ifosfamide', 'paclitaxel', 'carboplatin'], 'is_context_needed': True}] |
Ticlopidine and clopidogrel achieve antiplatelet effects by inhibiting the binding of adenosine 5'-disphosphate to its platelet receptor . | [{'class': 'POS', 'spans': ['Ticlopidine', 'clopidogrel'], 'is_context_needed': True}] |
Irinotecan plus gemcitabine induces both radiographic and CA 19 - 9 tumor marker responses in patients with previously untreated advanced pancreatic cancer . | [{'class': 'POS', 'spans': ['Irinotecan', 'gemcitabine'], 'is_context_needed': True}] |
The patient was treated with a combination of cyclophosphamide , doxorubicin , vincristine , and prednisone as initial management immediately after diagnosis . | [{'class': 'POS', 'spans': ['cyclophosphamide', 'doxorubicin', 'vincristine', 'prednisone'], 'is_context_needed': True}] |
To our knowledge , we present the first reported case of SS associated with linezolid and methadone with a brief review of the literature . | [{'class': 'NEG', 'spans': ['linezolid', 'methadone'], 'is_context_needed': True}] |
Recent clinical trials have reported improved survival for two novel agents ; ipilimumab , a humanized , IgG1 monoclonal antibody that blocks cytotoxic T-lymphocyte-associated antigen 4 ( CTLA-4 ) and vemurafenib , a BRAF ( v-raf murine sarcoma viral oncogene homolog B1 ) inhibitor targeting an activating mutation in the serine-threonine-protein kinase BRAF gene . | [{'class': 'POS', 'spans': ['ipilimumab', 'vemurafenib'], 'is_context_needed': False}] |
Three interventions exhibited significantly improved OS results over chemotherapy ( all HR < 1 ): Ipilimumab , Nivolumab and Ipilimumab + Chemotherapy . | [{'class': 'POS', 'spans': ['Ipilimumab', 'Nivolumab', 'Ipilimumab', 'Chemotherapy'], 'is_context_needed': False}] |
The breast trial participants studied were those elderly enrolled between 1995 and 1997 and treated with doxorubicin and cyclophosphamide or this combination with paclitaxel . | [{'class': 'COMB', 'spans': ['doxorubicin', 'cyclophosphamide'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 1, 2], 'is_context_needed': True}] |
The intensive polychemotherapy regimen eBEACOPP ( bleomycin , etoposide , doxorubicin , cyclophosphamide , vincristine , procarbazine , and prednisone in escalated doses ) is very active in patients with advanced-stage Hodgkin 's lymphoma , albeit at the expense of severe toxicities . | [{'class': 'COMB', 'spans': ['bleomycin', 'etoposide', 'doxorubicin', 'cyclophosphamide', 'vincristine', 'procarbazine', 'prednisone'], 'is_context_needed': True}] |
Systemic treatments , and here in particular a combined therapeutic regimen of chemotherapy and electron beam , bexarotene , or denileukin diftitox , showed more adverse effects than topical or skin-directed treatments . | [{'class': 'NEG', 'spans': ['bexarotene', 'denileukin diftitox'], 'is_context_needed': False}] |
Risk factors associated with cardiotoxicity within 2 years of doxorubicin administration included age [ adjusted hazard ratio ( aHR ) = 1.02 , 95 % confidence interval ( CI ) 1.00 - 1.04 ; p = 0.05 ] , metastasis ( aHR = 2.66 ; 95 % CI 1.36 - 5.20 ; p < 0.01 ) , and concomitant trastuzumab ( aHR = 4.08 ; 95 % CI 2.31 - 7.21 ; p | [{'class': 'NEG', 'spans': ['doxorubicin', 'trastuzumab'], 'is_context_needed': True}] |
Twenty-four patients have been treated to date , and the maximum tolerated dose has been reached at paclitaxel 185 mg/m2 and carboplatin 350 mg/m2 . | [{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': True}] |
[ Aztreonam or gentamicin combined with piperacillin as empiric antibiotic therapy during neutropenia of patients with hematologic diseases ] . | [{'class': 'POS', 'spans': ['Aztreonam', 'piperacillin'], 'is_context_needed': True}, {'class': 'POS', 'spans': [1, 2], 'is_context_needed': True}] |
The present study was undertaken to further elucidate the effect of salbutamol on the pharmacokinetics of digoxin in man . | [{'class': 'COMB', 'spans': ['salbutamol', 'digoxin'], 'is_context_needed': True}] |
Mecamylamine reversed the effects of nicotine on SHR performance . | [{'class': 'POS', 'spans': ['Mecamylamine', 'nicotine'], 'is_context_needed': True}] |
The combination of sub-effective doses of leflunomide and cyclosporin A resulted in significant inhibition of chronic arthritis . | [{'class': 'POS', 'spans': ['leflunomide', 'cyclosporin'], 'is_context_needed': False}] |
In the metastatic setting , FOLFIRINOX ( folinic acid , 5-fluorouracil , irinotecan , and oxaliplatin ) , and nab-paclitaxel plus gemcitabine have yielded only modest improvements in survival . | [{'class': 'COMB', 'spans': ['folinic', '5-fluorouracil', 'irinotecan', 'oxaliplatin'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [4, 5], 'is_context_needed': True}] |
Patients in arm 1 ( n = 88 ) received 4 cycles of paclitaxel and carboplatin followed by 2 to 4 cycles of gemcitabine-based combination chemotherapy . | [{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin', 'gemcitabine-based'], 'is_context_needed': True}] |
In patients receiving digoxin and propafenone simultaneously , the SDCs should be monitored and the digoxin dose reduced if there is evidence of toxicity . | [{'class': 'COMB', 'spans': ['digoxin', 'propafenone'], 'is_context_needed': True}] |
To review the clinical effectiveness and cost-effectiveness evidence base for lapatinib ( LAP ) in combination with an aromatase inhibitor ( AI ) and trastuzumab ( TRA ) in combination with an AI for the first-line treatment of patients who have hormone receptor-positive (HR+)/human epidermal growth factor 2-positive ( HER2 + ) mBC . | [{'class': 'POS', 'spans': ['lapatinib', 'AI'], 'is_context_needed': True}, {'class': 'POS', 'spans': [1, 2], 'is_context_needed': True}] |
Since combination therapy with nateglinide and vildagliptin restored the decrease in pancreatic beta cell mass , our present findings suggest that combination therapy could be a promising therapeutic strategy for postprandial dysmetabolism associated with obese and insulin resistance . | [{'class': 'POS', 'spans': ['nateglinide', 'vildagliptin'], 'is_context_needed': False}] |
Patients were randomised to receive either four or eight courses of cytotoxic chemotherapy with cyclophosphamide , vincristine and etoposide and also randomised to receive , on disease progression , either second line chemotherapy ( methotrexate and doxorubicin ) or symptomatic treatment only . | [{'class': 'POS', 'spans': ['cyclophosphamide', 'vincristine', 'etoposide'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [3, 4], 'is_context_needed': True}] |
Tazobactam has inhibitory activity , and therefore protects piperacillin against Richmond and Sykes types II , III , IV and V beta-lactamases , staphylococcal penicillinase and extended-spectrum beta-lactamases . | [{'class': 'POS', 'spans': ['Tazobactam', 'piperacillin'], 'is_context_needed': True}] |
The diagnosis was stage IIIA HHV-8-LBL , and he was treated with 6 cycles of R-EPOCH ( rituximab , etoposide , vincristine , doxorubicin , cyclophosphamide , and prednisone ) infusion chemotherapy . | [{'class': 'POS', 'spans': ['rituximab', 'etoposide', 'vincristine', 'doxorubicin', 'cyclophosphamide', 'prednisone'], 'is_context_needed': True}] |
Our objective was to define the maximum tolerated dose of an escalating dose of ifosfamide in combination with a fixed dose of doxorubicin supported by granulocyte colony-stimulating factor ( Neupogen ) . | [{'class': 'POS', 'spans': ['ifosfamide', 'doxorubicin'], 'is_context_needed': True}] |
A combined analysis of two pivotal randomized trials of a single dose of pegfilgrastim per chemotherapy cycle and daily Filgrastim in patients with stage II-IV breast cancer . | [{'class': 'POS', 'spans': ['pegfilgrastim', 'Filgrastim'], 'is_context_needed': True}] |
At initial treatment with dabrafenib plus trametinib , three patients achieved a partial response and one patient achieved a complete response . | [{'class': 'POS', 'spans': ['dabrafenib', 'trametinib'], 'is_context_needed': True}] |
We performed this meta-analysis to evaluate the clinical efficacy and safety of gemcitabine plus cisplatin ( GP ) and paclitaxel plus cisplatin ( TP ) combined with thermotherapy in the treatment of NSCLC , as well as to provide reference for clinical practice and future research . | [{'class': 'POS', 'spans': ['gemcitabine', 'cisplatin', 'thermotherapy'], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 3, 4], 'is_context_needed': True}] |
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