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Ultimately , the patient was successfully treated with combination therapy of Liposomal amphotericin B and Miltefosine without any relapse . | [{'class': 'POS', 'spans': ['amphotericin', 'Miltefosine'], 'is_context_needed': False}] |
However , verapamil significantly increased the sensitivity to etoposide , doxorubicin and vincristine in cells highly expressing MRP gene . | [{'class': 'POS', 'spans': ['verapamil', 'etoposide'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 3], 'is_context_needed': False}] |
Synergy was observed in vitro when HCT-116 cells were treated over a broad range of doses of trametinib and palbociclib . | [{'class': 'POS', 'spans': ['trametinib', 'palbociclib'], 'is_context_needed': False}] |
Using a FOLFOXIRI ( 5-fluorouracil [ 5-FU ] , irinotecan , and oxaliplatin ) combination regimen , patients with metastatic colorectal cancer now have the possibility of longer survival , but disappointingly , with increased toxicities . | [{'class': 'POS', 'spans': ['5-FU', 'irinotecan', 'oxaliplatin'], 'is_context_needed': False}] |
Combinations of antibodies with targeted drugs like ibrutinib , idelalisib , or lenalidomide are expected to replace chemotherapy-based combinations for treating CLL in the near future . | [{'class': 'POS', 'spans': ['antibodies', 'ibrutinib'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 3], 'is_context_needed': False}] |
The responses to quinine and mefloquine or halofantrine showed no correlation with each other . | [{'class': 'COMB', 'spans': ['quinine', 'mefloquine'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}] |
In a phase II study , we treated 26 consecutive patients with refractory advanced sarcoma with ifosfamide and etoposide combination chemotherapy . | [{'class': 'POS', 'spans': ['ifosfamide', 'etoposide'], 'is_context_needed': True}] |
A case of delivery of healthy infant in breast cancer patient incidentally treated with goserelin acetate and tamoxifen during pregnancy . | [{'class': 'POS', 'spans': ['goserelin acetate', 'tamoxifen'], 'is_context_needed': False}] |
Treatment-naive patients with nonmetastatic N2 or N3 SCCHN were randomly assigned to CRT alone ( CRT arm ; docetaxel , fluorouracil , and hydroxyurea plus radiotherapy 0.15 Gy twice per day every other week ) versus two 21-day cycles of IC ( docetaxel 75 mg/m(2 ) on day 1 , cisplatin 75 mg/m(2 ) on day 1 , and fluorouracil 750 mg/m(2 ) on days 1 to 5 ) followed by the same CRT regimen ( IC + CRT arm ) . | [{'class': 'NEG', 'spans': ['docetaxel', 'cisplatin', 'fluorouracil'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 1, 2], 'is_context_needed': True}] |
The objective of this study was to compare the effect of sildenafil alone and sildenafil with bosentan on severity of tricuspid regurgitation and duration of hospitalization in new-borns with persistent pulmonary hypertension . | [{'class': 'POS', 'spans': ['sildenafil', 'bosentan'], 'is_context_needed': True}] |
In Crohn 's disease in remission after 6 months of azathioprine in combination with infliximab , 63.8 % of practitioners discontinued azathioprine . | [{'class': 'NEG', 'spans': ['azathioprine', 'infliximab'], 'is_context_needed': False}] |
Long-term outcome for men with androgen independent prostate cancer treated with ketoconazole and hydrocortisone . | [{'class': 'POS', 'spans': ['ketoconazole', 'hydrocortisone'], 'is_context_needed': False}] |
Randomized trial of betahistine mesilate tablets as augmentation for oxcarbazepine and carbamazepine in treating vestibular paroxysmia . | [{'class': 'POS', 'spans': ['betahistine', 'oxcarbazepine'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': True}] |
Sorafenib in combination with gemcitabine in recurrent epithelial ovarian cancer : a study of the Princess Margaret Hospital Phase II Consortium . | [{'class': 'POS', 'spans': ['Sorafenib', 'gemcitabine'], 'is_context_needed': True}] |
Pharmacological inhibition of p70S6 K using the PI3K/mTOR inhibitor NVP-BEZ235 , the specific mTOR inhibitor Rapamycin and the specific p70S6 K inhibitor PF-4708671 potentiated Selumetinib effects in resistant cells . | [{'class': 'POS', 'spans': ['Selumetinib', 'NVP-BEZ235'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 1], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 3], 'is_context_needed': False}] |
Vinorelbine , ifosfamide and cisplatin as first-line treatment in patients with inoperable non-small cell lung cancer . | [{'class': 'POS', 'spans': ['Vinorelbine', 'ifosfamide', 'cisplatin'], 'is_context_needed': True}] |
Two large Phase III trials conducted in the Americas and across Europe , Australia , and Asia showed lower cumulative pregnancy rates in the NOMAC/E2 groups compared to the drospirenone ( DRSP ) 3 mg in combination with ethinyl estradiol ( EE ) 30 µg ( DRSP/EE ) groups but this difference was not statistically significant . | [{'class': 'POS', 'spans': ['drospirenone', 'ethinyl estradiol'], 'is_context_needed': False}] |
The objective was to compare the pharmacodynamic ( PD ) and pharmacokinetic ( PK ) effects of ticagrelor with clopidogrel among subjects of Hispanic ethnicity , as the PD and PK effects of antiplatelet agents among Hispanics are not specifically known . | [{'class': 'COMB', 'spans': ['ticagrelor', 'clopidogrel'], 'is_context_needed': True}] |
For example , the renal excretion of methotrexate by glomerular filtration and tubular secretion is affected by a number of weak organic acids , such as probenecid , salicylates and penicillin , which compete for tubular secretion , resulting in delayed clearance of methotrexate . | [{'class': 'POS', 'spans': ['methotrexate', 'probenecid'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 3], 'is_context_needed': False}] |
To investigate the cardiac safety of adjuvant Non-Pegylated Liposomal Doxorubicin ( NPL-DOX ) combined to Cyclophosphamide ( CTX ) and followed by weekly Paclitaxel , in older patients ( ≥65 years ) with diagnosis of high risk breast cancer . | [{'class': 'POS', 'spans': ['Doxorubicin', 'Cyclophosphamide', 'Paclitaxel'], 'is_context_needed': True}] |
The high incidence of imported malaria ( 0.70 % ) and the low costs of providing chemoprophylaxis resulted in a cost-benefit ratio of 0.19 for chloroquine and proguanil and 0.57 for a regimen containing mefloquine . | [{'class': 'POS', 'spans': ['chloroquine', 'proguanil'], 'is_context_needed': False}] |
Clinical trials suggest reduced benefit from the combination of cetuximab with oxaliplatin . | [{'class': 'NEG', 'spans': ['cetuximab', 'oxaliplatin'], 'is_context_needed': False}] |
L-carnitine was administered 1 h before doxorubicin injection and daily thereafter for 15 days . | [{'class': 'POS', 'spans': ['L-carnitine', 'doxorubicin'], 'is_context_needed': True}] |
Recoveries of both amino acids were increased bilaterally by local perfusion with veratridine ( 100 microM , given under halothane anaesthesia ) , pretreatment with reserpine ( 4 mg/kg , i.p . , 24 h beforehand ) , unilateral pretreatment of the medial forebrain bundle with 6-OHDA ( 8 microg/4 microl ) , and by the systemic ( 1 mg/kg , i.p . ) or bilateral intrastriatal ( 7 microg/0.5 microl under halothane anaesthesia ) administration of the dopamine D2 receptor antagonist haloperidol , but not raclopride ( 2 mg/kg , i.p . ) . | [{'class': 'POS', 'spans': ['reserpine', 'veratridine'], 'is_context_needed': False}, {'class': 'POS', 'spans': [3, 5], 'is_context_needed': False}, {'class': 'NEG', 'spans': [5, 6], 'is_context_needed': False}] |
Combined initial cyclophosphamide with repeated methylprednisolone pulse therapy for severe paraquat poisoning from dermal exposure . | [{'class': 'POS', 'spans': ['cyclophosphamide', 'methylprednisolone'], 'is_context_needed': True}] |
Hyper-CVAD , given in odd-number courses ( Courses 1 , 3 , 5 , and 7 ) , was alternated with methotrexate and cytarabine ( MTX/Ara-C ) , given in even-number courses ( Courses 2 , 4 , 6 , and 8) . | [{'class': 'POS', 'spans': ['methotrexate', 'cytarabine'], 'is_context_needed': True}] |
Despite systemic chemotherapy combining pemetrexed , bevacizumab and Cisplatinum , the disease relapsed eight months later with multiple metastatic lung nodules leading to a treatment shift . | [{'class': 'NEG', 'spans': ['pemetrexed', 'bevacizumab', 'Cisplatinum'], 'is_context_needed': False}] |
Pretreatment with NaHCO3 , NH4Cl , SKF 525A , piperonyl butoxide , progesterone , cysteamine , phenobarbital or metyrapone prior to the administration of [methyl-14C]nicotine was studied . | [{'class': 'POS', 'spans': ['[methyl-14C]nicotine', 'metyrapone'], 'is_context_needed': True}, {'class': 'POS', 'spans': [8, 4], 'is_context_needed': True}] |
Because the mass invaded the pancreas and superior mesenteric vein as well as duodenum and the disease was disseminated to liver and peritoneum , she received palliative chemotherapy using vincristine , doxorubicin , cyclophosphamide , ifosfamide , and etoposide . | [{'class': 'POS', 'spans': ['vincristine', 'doxorubicin', 'cyclophosphamide', 'ifosfamide', 'etoposide'], 'is_context_needed': False}] |
In HCV genotype 1 infection and F3 or F4 liver fibrosis , treatment with boceprevir or telaprevir in addition to pegylated interferon and ribavirin is recommended . | [{'class': 'POS', 'spans': ['boceprevir', 'pegylated interferon', 'ribavirin'], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 2, 3], 'is_context_needed': False}] |
The combination of ifosfamide with oral etoposide appears to have significant but manageable toxicity and encouraging efficacy in platinum resistant ovarian cancer . | [{'class': 'POS', 'spans': ['ifosfamide', 'etoposide'], 'is_context_needed': False}] |
This Phase I , randomized , open-label study evaluated the gastric pH-altering effects of omeprazole , a proton pump inhibitor , and the CYP3A enzyme/P-glycoprotein (Pgp)-inhibitory effects of ritonavir , an HIV protease inhibitor , on the pharmacokinetics and safety of the hepatitis C virus ( HCV ) non-structural protein 5A ( NS5A ) inhibitor GSK2336805 in healthy male and female subjects . | [{'class': 'POS', 'spans': ['omeprazole', 'ritonavir', 'GSK2336805'], 'is_context_needed': True}] |
Phase II study of weekly paclitaxel and sorafenib as second/third-line therapy in patients with adrenocortical carcinoma . | [{'class': 'NEG', 'spans': ['paclitaxel', 'sorafenib'], 'is_context_needed': True}] |
This study indicates that cyclophosphamide , doxorubicin , and methotrexate are , at best , marginally active as single agents , and new drugs with more efficacy are needed before combination chemotherapy can be expected to result in any meaningful prolongation of survival in non-small cell lung cancer . | [{'class': 'POS', 'spans': ['cyclophosphamide', 'doxorubicin', 'methotrexate'], 'is_context_needed': True}] |
The combined treatment of curcumin and docetaxel inhibited the proliferation and induced apoptosis significantly higher than the curcumin and docetaxel-treated group alone . | [{'class': 'POS', 'spans': ['curcumin', 'docetaxel'], 'is_context_needed': False}] |
Previously , a study of ours showed that the combination of dabrafenib and trametinib improves progression-free survival compared with dabrafenib and placebo in patients with BRAF Val600Lys/Glu mutation-positive metastatic melanoma . | [{'class': 'POS', 'spans': ['dabrafenib', 'trametinib'], 'is_context_needed': False}] |
compared to those for rats treated with trovafloxacin or clindamycin plus gentamicin | [{'class': 'NEG', 'spans': ['clindamycin', 'gentamicin'], 'is_context_needed': True}] |
All but one received two induction courses of the 3 day-AVI ( doxorubicin 50 mg/m(2 ) day 1 , etoposide 120 mg/m(2 ) day 1 , 2 , 3 , ifosfamide 2000 mg/m(2 ) day 1 , 2 ) regimen . | [{'class': 'POS', 'spans': ['doxorubicin', 'etoposide', 'ifosfamide'], 'is_context_needed': True}] |
In the phase I trial , 19 patients received bolus doxorubicin ( 50 mg/m2 ) followed after a 16-hour interval by paclitaxel ( given at dose levels ranging from 130 to 250 mg/m2 ) by 3-hour infusion every 3 weeks , for a maximum of eight cycles . | [{'class': 'POS', 'spans': ['doxorubicin', 'paclitaxel'], 'is_context_needed': True}] |
Exposure of LLC-PK1 cells to hydrogen peroxide ( 2.5 mM ) resulted in a significant increase in the bleomycin-detectable iron ( iron capable of catalyzing free radical reactions ) content that was prevented by cimetidine , but not ranitidine . | [{'class': 'POS', 'spans': ['hydrogen peroxide', 'cimetidine'], 'is_context_needed': False}, {'class': 'NEG', 'spans': [0, 2], 'is_context_needed': False}] |
Patients were randomly assigned 1:1 centrally to either the docetaxel , prednisone , and custirsen combination or docetaxel and prednisone alone . | [{'class': 'POS', 'spans': ['docetaxel', 'prednisone', 'custirsen'], 'is_context_needed': True}] |
[ Carboplatin and etoposide combination for the treatment of recurrent epithelial ovarian cancer ] . | [{'class': 'POS', 'spans': ['Carboplatin', 'etoposide'], 'is_context_needed': True}] |
One-hour paclitaxel plus carboplatin in the treatment of advanced non-small cell lung cancer : results of a multicentre , phase II trial . | [{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': True}] |
Preliminary data combining trastuzumab with the antiangiogenic antibody bevacizumab is encouraging ; this combination will be tested in both early stage and late stage disease . | [{'class': 'POS', 'spans': ['trastuzumab', 'bevacizumab'], 'is_context_needed': False}] |
A decrease in VEGF-A expression in the tumor node and salivary gland was found after monotherapy with melatonin and cyclophosphamide and , especially , after combined treatment , which proves maximum therapeutic efficiency of combined administration of chemical agents with various mechanisms of action . | [{'class': 'POS', 'spans': ['melatonin', 'cyclophosphamide'], 'is_context_needed': False}] |
The combination of rituximab , bendamustine , and cytarabine ( R-BAC ) was highly active in a pilot trial of mantle cell lymphoma , but its use was restricted by high haematological toxicity . | [{'class': 'POS', 'spans': ['rituximab', 'bendamustine', 'cytarabine'], 'is_context_needed': False}] |
Despite treatment with PH specific therapy ( sildenafil , ambrisentan , and epoprostenol ) , her condition worsened rapidly with acute right heart failure ( RHF ) . | [{'class': 'COMB', 'spans': ['sildenafil', 'ambrisentan', 'epoprostenol'], 'is_context_needed': True}] |
Data from the present study show the feasibility and tolerability of combination ixabepilone plus carboplatin , with ixabepilone administered on day 1 or on days 1 and 8 on a 21-day cycle . | [{'class': 'COMB', 'spans': ['ixabepilone', 'carboplatin'], 'is_context_needed': True}] |
Thirteen stage III B and 13 stage IV patients received intermediate doses of ifosfamide ( 1000 mg/m2 ) , carboplatin ( 120 mg/m2 ) and etoposide ( 120 mg/m2 ) given intravenously on day 1 to 3 every 4 weeks . | [{'class': 'POS', 'spans': ['ifosfamide', 'carboplatin', 'etoposide'], 'is_context_needed': True}] |
The null hypothesis was there is no difference with respect to pain scores between ketorolac and iliac crest bupivacaine infusion as analgesic adjuncts to intravenous opioids . | [{'class': 'POS', 'spans': ['ketorolac', 'bupivacaine'], 'is_context_needed': True}] |
Etoposide in combination with low-dose CAG ( cytarabine , aclarubicin , G-CSF ) for the treatment of relapsed or refractory acute myeloid leukemia : a multicenter , randomized control trial in southwest China . | [{'class': 'POS', 'spans': ['Etoposide', 'cytarabine', 'aclarubicin', 'G-CSF'], 'is_context_needed': True}] |
were randomized in an open-label , crossover fashion to treatment A ( dolasetron 100 mg on day 1 ) and treatment B ( dolasetron 100 mg plus aprepitant 125 mg on day 1 , aprepitant 80 mg on days 2 - 3 ) . | [{'class': 'POS', 'spans': ['dolasetron', 'aprepitant'], 'is_context_needed': True}] |
The regimen of gemcitabine combined with ifosfamide and anthracycline is feasible , tolerable and effective in patients with recurrent platinum resistant/refractory epithelial ovarian cancer . | [{'class': 'POS', 'spans': ['gemcitabine', 'ifosfamide', 'anthracycline'], 'is_context_needed': False}] |
Second-line treatments consisted of cetuximab plus irinotecan for arm A , and oxaliplatin plus either 5-fluorouracil ( FOLFOX ) or capecitabine ( CapeOX ) for the control arms . | [{'class': 'POS', 'spans': ['cetuximab', 'irinotecan'], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 4], 'is_context_needed': True}] |
In the UT-EC-1 cell line the growth inhibition was 72 % with paclitaxel , 54 % with carboplatin and 73 % with the combination of these compounds . | [{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': True}] |
Several lines of evidence implicate serotonin ( 5-HT ) as the mediator of this enhancement : ( 1 ) Tranyclypromine-enhanced nicotine reinforcement was blocked by the 5-HT₂ receptor antagonists , ritanserin and ketanserin ; ( 2 ) parachloroamphetamine ( PCA ) , a 5-HT releaser , also enhanced nicotine self-administration in animals in which MAO activity was inhibited ; ( 3 ) pretreatment with tranylcypromine increased PCA-induced 5-HT overflow in the nucleus accumbens . | [{'class': 'COMB', 'spans': ['nicotine', 'ketanserin'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [2, 4], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 5], 'is_context_needed': True}] |
Ursodeoxycholic acid is conjugated with taurine to promote secretin-stimulated biliary hydrocholeresis in the normal rat . | [{'class': 'POS', 'spans': ['Ursodeoxycholic acid', 'taurine'], 'is_context_needed': True}] |
This study assessed the efficacy and safety of telaprevir in combination with peginterferon-α-2b ( PEG IFN ) and ribavirin ( RBV ) , for Japanese difficult-to-treat patients with hepatitis C virus ( HCV ) genotype 2 who had not achieved sustained virological response ( SVR ) during prior treatment . | [{'class': 'POS', 'spans': ['telaprevir', 'peginterferon-α-2b'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}] |
Combination of a betalactam antibiotic ( ampicillin or azlocillin ) or polymyxin B with rifampicin were studied with their administration in succession at various intervals in an experimental model of plague infection of albino mice . | [{'class': 'POS', 'spans': ['ampicillin', 'rifampicin'], 'is_context_needed': True}, {'class': 'POS', 'spans': [1, 3], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': True}] |
Previous treatments with rituximab and with rituximab plus high dose glucocorticoids , as well as with cyclophosphamide , azathioprine , plasma exchange , hyperbaric therapy , VAC therapy , prostacyclin , mycophenolate mofetil and surgery , had previously failed . | [{'class': 'NEG', 'spans': ['rituximab', 'glucocorticoids'], 'is_context_needed': False}, {'class': 'NEG', 'spans': [1, 2], 'is_context_needed': False}, {'class': 'NEG', 'spans': [1, 3], 'is_context_needed': False}] |
The decision to test a triple combination has led to the development of Fansimef , a fixed combination with tablets containing 250 mg mefloquine , 500 mg sulfadoxine and 25 mg pyrimethamine . | [{'class': 'POS', 'spans': ['mefloquine', 'sulfadoxine', 'pyrimethamine'], 'is_context_needed': True}] |
The aim of this study was to evaluate three active agents , bleomycin ( BLM ) , epirubicin and carboplatin in a new combination ( BECA ) in terms of feasibility , activity and toxicity in patients with recurrent and metastatic squamous cell carcinoma of the head and neck . | [{'class': 'POS', 'spans': ['bleomycin', 'epirubicin', 'carboplatin'], 'is_context_needed': True}] |
A phase II trial of cytarabine , cisplatin , and etoposide was conducted in 38 patients with refractory stage III and IV non-Hodgkin 's lymphoma . | [{'class': 'COMB', 'spans': ['cytarabine', 'cisplatin', 'etoposide'], 'is_context_needed': True}] |
The combination of camrelizumab plus gemcitabine and cisplatin has a manageable toxicity profile and promising preliminary antitumour activity for this disease in treatment-naive patients . | [{'class': 'POS', 'spans': ['camrelizumab', 'gemcitabine', 'cisplatin'], 'is_context_needed': False}] |
His infection failed to respond to combinations of surgery , fluconazole and itraconazole . | [{'class': 'NEG', 'spans': ['fluconazole', 'itraconazole'], 'is_context_needed': True}] |
The protective effect of tianeptine against PTZ seizures was mitigated when tianeptine was administered with naloxone . | [{'class': 'COMB', 'spans': ['tianeptine', 'naloxone'], 'is_context_needed': True}] |
The sensitivity of human neuroblastoma-derived cell lines , cell line-derived , and patient-derived xenograft ( PDX ) models with varying ALK statuses to crizotinib combined with topotecan and cyclophosphamide ( topo/cyclo ) was examined . | [{'class': 'POS', 'spans': ['crizotinib', 'topotecan', 'cyclophosphamide'], 'is_context_needed': True}] |
Patients were randomised to either receive additional tretinoin ( 45mg/m(2)/day ) for 12 weeks ( arm A ) , or peg-interferon and ribavirin alone ( arm B ) . | [{'class': 'COMB', 'spans': ['ribavirin', 'peg-interferon'], 'is_context_needed': True}] |
This study sought to determine the efficacy and toxicity of weekly paclitaxel and carboplatin in CUP . | [{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': True}] |
The patient achieved complete remission after two cycles of chemotherapy of daunorubicin , cytarabine and etoposide . | [{'class': 'POS', 'spans': ['daunorubicin', 'cytarabine', 'etoposide'], 'is_context_needed': False}] |
This synergy was abrogated through siRNA knockdown of IkB. The synergistic effect of combining selinexor and bortezomib in vitro provides rationale for further investigation of this combination treatment for patients with high-risk neuroblastoma . | [{'class': 'POS', 'spans': ['selinexor', 'bortezomib'], 'is_context_needed': False}] |
Therapy included 4 or 8 intensive therapy elements N1 ( Etoposide 125 mg/m2 day 1 - 4 , Vindesine 3 mg/m2 day 1 , Cisplatin 40 mg/m2 day 1 - 4 ) and N2 ( Vincristine 1.5 mg/m2 day 1 + 8 , Dacarbazine 200 mg/m2 day 1 - 5 , Ifosfamide 1500 mg/ m2 day 1 - 5 , Doxorubicin 30 mg/m2 day 6 + 7 ) in alternating order . | [{'class': 'POS', 'spans': ['Etoposide', 'Cisplatin', 'Vindesine'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [2, 3, 4, 5], 'is_context_needed': True}] |
Efficacy and safety of tacrolimus and low-dose prednisone in Chinese children with steroid-resistant nephrotic syndrome . | [{'class': 'POS', 'spans': ['tacrolimus', 'prednisone'], 'is_context_needed': True}] |
Genistein reduced Bcl-2 phosphorylation triggered by paclitaxel and vincristine without changing Bax protein expression . | [{'class': 'POS', 'spans': ['Genistein', 'paclitaxel'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}] |
This Nordic multicenter phase II study evaluated the efficacy and safety of oxaliplatin combined with the Nordic bolus schedule of fluorouracil ( FU ) and folinic acid ( FA ) as first-line treatment in metastatic colorectal cancer . | [{'class': 'POS', 'spans': ['oxaliplatin', 'fluorouracil', 'folinic acid'], 'is_context_needed': True}] |
In xenograft studies , the combination of trastuzumab plus letrozole is equally effective in inhibiting growth of MCF-7Ca tumors as letrozole alone . | [{'class': 'POS', 'spans': ['trastuzumab', 'letrozole'], 'is_context_needed': False}] |
The patient showed a substantial response to treatment with a combination of antimicrobial therapies consisting of clarithromycin , amikacin , and cefoxitin for 6 months . | [{'class': 'POS', 'spans': ['clarithromycin', 'amikacin', 'cefoxitin'], 'is_context_needed': False}] |
The methods have been utilized to evaluate the pharmacokinetics and bioavailability of oral dosage forms containing levodopa and carbidopa . | [{'class': 'COMB', 'spans': ['levodopa', 'carbidopa'], 'is_context_needed': True}] |
Contribution of moxifloxacin or levofloxacin in second-line regimens with or without continuation of pyrazinamide in murine tuberculosis . | [{'class': 'POS', 'spans': ['moxifloxacin', 'pyrazinamide'], 'is_context_needed': True}, {'class': 'POS', 'spans': [1, 2], 'is_context_needed': True}] |
The addition of tamoxifen did not worsen the known side effects of gefitinib , or induce additional side effects . | [{'class': 'COMB', 'spans': ['tamoxifen', 'gefitinib'], 'is_context_needed': True}] |
A topical combination of 0.25 % finasteride and 3 % minoxidil may be a promising option in the treatment of FPHL with an additional benefit of increasing hair diameter . | [{'class': 'POS', 'spans': ['finasteride', 'minoxidil'], 'is_context_needed': False}] |
Acute verapamil toxicity in a patient with chronic toxicity : possible interaction with ceftriaxone and clindamycin . | [{'class': 'NEG', 'spans': ['verapamil', 'ceftriaxone', 'clindamycin'], 'is_context_needed': False}] |
Eighty-three patients were treated with rituximab , cyclophosphamide , doxorubicin , vincristine , prednisone ( R-CHOP ) , 7 with rituximab , etoposide , cyclophosphamide , doxorubicin , vincristine , prednisone ( R-EPOCH ) , and 6 with R-CHOP with methotrexate , 3 g/m(2 ) . | [{'class': 'NEG', 'spans': ['rituximab', 'cyclophosphamide', 'doxorubicin', 'vincristine', 'prednisone'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [6, 7, 8, 9, 10, 11], 'is_context_needed': True}, {'class': 'NEG', 'spans': [12, 13], 'is_context_needed': True}] |
Among them , 18 ( 85.7 % ) patients had disease control with gefitinib and 12 ( 57.1 % ) patients with salvage erlotinib . | [{'class': 'POS', 'spans': ['gefitinib', 'erlotinib'], 'is_context_needed': True}] |
The combination of volasertib with pemetrexed did not improve efficacy compared with pemetrexed monotherapy . | [{'class': 'NEG', 'spans': ['volasertib', 'pemetrexed'], 'is_context_needed': False}] |
A phase I/II study was carried out to determine the maximum tolerated dose of paclitaxel ( Taxol ; Bristol-Myers Squibb Company , Princeton , NJ ) in combination with a fixed dose of carboplatin ( area under the concentration-time curve = 6 by Calvert method ) given on an every-3-week schedule to patients with non-small cell lung cancer ( NSCLC ) . | [{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': True}] |
These results suggest that therapy with insulin plus dexamethasone but not therapy with leptin is beneficial for diabetics . | [{'class': 'POS', 'spans': ['dexamethasone', 'insulin'], 'is_context_needed': False}] |
This study investigated the efficacy and toxicity associated with consolidation chemotherapy using paclitaxel and carboplatin after concurrent chemoradiation ( CCR ) in cervical cancer patients . | [{'class': 'NEG', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': True}] |
Cladribine with Granulocyte Colony-Stimulating Factor , Cytarabine , and Aclarubicin Regimen in Refractory/Relapsed Acute Myeloid Leukemia : A Phase II Multicenter Study . | [{'class': 'POS', 'spans': ['Cladribine', 'Granulocyte Colony-Stimulating Factor', 'Cytarabine', 'Aclarubicin'], 'is_context_needed': True}] |
Combining erlotinib with doxorubicin or docetaxel or SN-38 resulted in additive or even synergistic antiproliferative effects . | [{'class': 'POS', 'spans': ['erlotinib', 'doxorubicin'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 3], 'is_context_needed': False}] |
The present work is concerned with simultaneous determination of cefepime ( CEF ) and the co-administered drug , levofloxacin ( LEV ) , in spiked human plasma by applying a new approach , Savitzky-Golay differentiation filters , and combined trigonometric Fourier functions to their ratio spectra . | [{'class': 'POS', 'spans': ['cefepime', 'levofloxacin'], 'is_context_needed': False}] |
Forthcoming data from phase 3 placebo-controlled trials of everolimus , one focused on monotherapy for pancreatic NET and the other on combination use with octreotide LAR for patients with advanced NET and a history of carcinoid syndrome , will provide insight into its future place in NET therapy . | [{'class': 'COMB', 'spans': ['everolimus', 'octreotide'], 'is_context_needed': True}] |
The effects of prednisone and azathioprine on circulating immunoglobulin levels and lymphocyte subpopulations in normal dogs . | [{'class': 'NEG', 'spans': ['prednisone', 'azathioprine'], 'is_context_needed': True}] |
The analytical range for dihydroartemisinin , dihydroartemisinin-glucuronide and artesunate was 10 - 1000 ng/ml and for artemether 90 - 3000 ng/ml with a lower limit of quantification of 10 and 90 ng/ml , respectively . | [{'class': 'COMB', 'spans': ['dihydroartemisinin', 'dihydroartemisinin-glucuronide', 'artesunate'], 'is_context_needed': True}] |
Amphotericin B MICs were reduced upon combination with rifabutin from a mean of 0.65 microg/ml to a mean of 0.16 microg/ml against Aspergillus , and from a mean of 0.97 microg/ml to a mean of 0.39 microLg/ml against Fusarium ( P < 0.000001 for both ) . | [{'class': 'POS', 'spans': ['Amphotericin', 'rifabutin'], 'is_context_needed': True}] |
Neoadjuvant therapy with gemcitabine plus doxorubicin results in a high tumor response rate with moderate oral and hematologic toxicity . | [{'class': 'POS', 'spans': ['gemcitabine', 'doxorubicin'], 'is_context_needed': False}] |
In this parallel group , randomized , double-blind study , 301 PD patients , the majority with motor fluctuations , received entacapone ( 200 mg ) or placebo with each daily dose of standard or controlled-release ( CR ) levodopa . | [{'class': 'POS', 'spans': ['entacapone', 'levodopa'], 'is_context_needed': True}] |
Importance of adding neomycin to metronidazole for bowel preparation . | [{'class': 'POS', 'spans': ['neomycin', 'metronidazole'], 'is_context_needed': False}] |
A combination chemotherapy regimen containing mitomycin-C ( 10 mg/m2 , day 2 ) , vincristine ( 0.5 mg/m2 , days 1 and 4 ) , bleomycin ( 30 U QD , days 1 - -4 as a continuous intravenous infusion during courses one and two only ) , and cis-platinum ( 50 mg/m2 , days 1 and 22 ) was administered every 6 weeks to 14 evaluable patients with advanced ( i.e. , Stage IVB ) and/or recurrent squamous cell carcinoma of the cervix . | [{'class': 'POS', 'spans': ['mitomycin-C', 'vincristine', 'bleomycin', 'cis-platinum'], 'is_context_needed': True}] |
Co-injection of the lowest doses of levobupivacaine and lidocaine dramatically increased the paw withdrawal latency . | [{'class': 'NEG', 'spans': ['levobupivacaine', 'lidocaine'], 'is_context_needed': True}] |
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