bala1524/Drug_Combination_Extraction · Datasets at Hugging Face

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Inflammatory breast cancer ( IBC ) is a rare , aggressive form of breast cancer associated with HER2 amplification , with high risk of metastasis and an estimated median survival of 2.9 y. We performed an open-label , single-arm phase II clinical trial ( ClinicalTrials.gov NCT01325428 ) to investigate the efficacy and safety of afatinib , an irreversible ErbB family inhibitor , alone and in combination with vinorelbine in patients with HER2-positive IBC .	[{'class': 'POS', 'spans': ['afatinib', 'vinorelbine'], 'is_context_needed': True}]
Carboplatin and paclitaxel versus cisplatin , paclitaxel and doxorubicin for first-line chemotherapy of advanced ovarian cancer : a Hellenic Cooperative Oncology Group ( HeCOG ) study .	[{'class': 'POS', 'spans': ['Carboplatin', 'paclitaxel'], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 3, 4], 'is_context_needed': True}]
For susceptibility testing , DS-8587 exhibited more effective antibacterial activity when compared with ciprofloxacin and levofloxacin .	[{'class': 'NEG', 'spans': ['ciprofloxacin', 'levofloxacin'], 'is_context_needed': False}]
Since 1987 , we have evaluated carboplatin alone or in combination with etoposide in two separate phase II trials of patients with non-small cell lung cancer ( NSCLC ) who had not received prior chemotherapy .	[{'class': 'COMB', 'spans': ['carboplatin', 'etoposide'], 'is_context_needed': True}]
FLAIE ( fludarabine , cytarabine , idarubicin , and etoposide ) , a four drug induction chemotherapy for adult acute myeloid leukemia : A single center experience .	[{'class': 'COMB', 'spans': ['fludarabine', 'cytarabine', 'idarubicin', 'etoposide'], 'is_context_needed': True}]
Overall , our study shows that the combination of dabrafenib and cetuximab results in increased antitumor activity and decreased stem cell capacities in BRAF(V600E)-mutant CRC cells .	[{'class': 'POS', 'spans': ['dabrafenib', 'cetuximab'], 'is_context_needed': False}]
Forty-seven patients with previously untreated metastatic or unresectable colorectal adenocarcinoma received capecitabine 1000 mg/m2 twice daily on days 2 - 15 and intravenous irinotecan 100 mg/m2 on days 1 and 8 , every 21 days .	[{'class': 'POS', 'spans': ['capecitabine', 'irinotecan'], 'is_context_needed': True}]
Amphotericin B plus flucytosine were initially given to 4 patients , all of them developed liver and renal abnormalities to some degree after therapy .	[{'class': 'NEG', 'spans': ['Amphotericin', 'flucytosine'], 'is_context_needed': False}]
Liposomes were surface modified with transferrin ( Tf ) for receptor targeting , and cell penetrating peptide PFVYLI ( PFV ) to increase translocation of doxorubicin ( Dox ) and Erlotinib ( Erlo ) across the BBB into glioblastoma ( U87 ) tumor cells .	[{'class': 'POS', 'spans': ['doxorubicin', 'Erlotinib'], 'is_context_needed': True}]
Endpoints were determination of maximum tolerated dose of doxorubicin and etoposide , treatment tolerability , and survival .	[{'class': 'POS', 'spans': ['doxorubicin', 'etoposide'], 'is_context_needed': True}]
Multiple ongoing clinical trials are currently evaluating the role of immune checkpoint inhibitors in ACC ( pembrolizumab , combination pembrolizumab and relacorilant , nivolumab , combination nivolumab and ipilimumab ) .	[{'class': 'COMB', 'spans': ['pembrolizumab', 'relacorilant'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [4, 5], 'is_context_needed': True}]
Bevacizumab and intetumumab can be administered safely in combination .	[{'class': 'POS', 'spans': ['Bevacizumab', 'intetumumab'], 'is_context_needed': False}]
The protocol consisted of oral gefitinib 250 mg daily for 1 year plus intravenous oxaliplatin 85 or 100 mg/m(2 ) on days 1 , 15 , and 29 , and RT ( 50.4 Gy in 28 1.8-Gy fractions ) .	[{'class': 'COMB', 'spans': ['gefitinib', 'oxaliplatin'], 'is_context_needed': True}]
Forty-eight patients were treated with mitoxantrone alone , 40 with mitoxantrone plus beta-interferon , 11 with fluorouracil plus folinic acid and the remaining four with adriamycin .	[{'class': 'COMB', 'spans': ['mitoxantrone', 'beta-interferon'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [2, 3], 'is_context_needed': True}]
Fifty-one HIV-negative patients with an average age of 50.3 years were treated with chemotherapy regimen included 2500 mg/m(2 ) MTX with Leucovorin rescue and 1.4 mg/m(2 ) vincristine ( day two ) , which was administered every other week for 6 weeks .	[{'class': 'COMB', 'spans': ['Leucovorin', 'vincristine'], 'is_context_needed': True}]
Phase I study of decitabine with doxorubicin and cyclophosphamide in children with neuroblastoma and other solid tumors : a Children 's Oncology Group study .	[{'class': 'NEG', 'spans': ['decitabine', 'doxorubicin'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [0, 2], 'is_context_needed': True}]
Our study involves a preliminary phase II trial , which evaluates the activity , feasibility and tolerability of a sequential combination of docetaxel and gemcitabine followed by docetaxel and carboplatin , as first-line treatment for inoperable NSCLC .	[{'class': 'POS', 'spans': ['docetaxel', 'gemcitabine', 'carboplatin'], 'is_context_needed': True}]
The combination of galunisertib and sorafenib showed acceptable safety and a prolonged OS outcome .	[{'class': 'POS', 'spans': ['galunisertib', 'sorafenib'], 'is_context_needed': False}]
All the patients were conditioned with busulfan ( BU ) 12 mg.kg-1 and cyclophosphamide ( CY ) 3.6 g.m-2 , of whom 4 were conditioned with additioned antithymocyte globulin(ATG ) .	[{'class': 'POS', 'spans': ['busulfan', 'cyclophosphamide', 'antithymocyte globulin(ATG'], 'is_context_needed': True}]
Phase II study of an intensive combination chemotherapy with cisplatin , adriamycin , etoposide and cyclophosphamide ( CAVE ) in small cell lung cancer .	[{'class': 'POS', 'spans': ['cisplatin', 'adriamycin', 'etoposide', 'cyclophosphamide'], 'is_context_needed': False}]
Simultaneous treatment with gefitinib and pemetrexed enhanced cell growth inhibition and cell death and prevented the appearance of gefitinib resistance mediated by T790 M mutation or epithelial-to-mesenchymal transition ( EMT ) in PC9 and HCC827 cells , respectively .	[{'class': 'POS', 'spans': ['gefitinib', 'pemetrexed'], 'is_context_needed': False}]
Two courses of eight drugs in 1 day followed by two courses of etoposide plus carboplatin ( 500 and 800 mg/m(2 ) per course , respectively ) were administered after surgery .	[{'class': 'POS', 'spans': ['etoposide', 'carboplatin'], 'is_context_needed': True}]
3 . When timolol was administered concomitantly with hydrochlorothiazide , plasma renin activity was suppressed and blood pressure was significantly lowered .	[{'class': 'POS', 'spans': ['timolol', 'hydrochlorothiazide'], 'is_context_needed': False}]
Phase I study combining treatment with temsirolimus and sunitinib malate in patients with advanced renal cell carcinoma .	[{'class': 'NEG', 'spans': ['temsirolimus', 'sunitinib'], 'is_context_needed': True}]
2 . The two combination treatment regimes lowered the 12 h post-dose blood pressure more effectively than did atenolol alone , but the high dose nifedipine combination was no more effective than the low dose nifedipine combination .	[{'class': 'POS', 'spans': ['atenolol', 'nifedipine'], 'is_context_needed': True}]
Low-risk patients received three cycles of modified CODOX-M ( cyclophosphamide , doxorubicin , adriamycin , vincristine with intrathecal methotrexate and cytarabine followed by high-dose systemic methotrexate , regimen A ) .	[{'class': 'POS', 'spans': ['cyclophosphamide', 'doxorubicin', 'vincristine', 'methotrexate', 'cytarabine', 'adriamycin'], 'is_context_needed': True}]
Background The National Wilms Tumor Study ( NWTS ) approach to treating stage III favorable-histology Wilms tumor ( FHWT ) is Regimen DD4A ( vincristine , dactinomycin , and doxorubicin ) and radiation therapy .	[{'class': 'POS', 'spans': ['vincristine', 'doxorubicin', 'dactinomycin'], 'is_context_needed': True}]
Enrolled patients received ADT in the form of leuprolide every 12 weeks for 24 months with bicalutamide initiating after the completion of chemotherapy .	[{'class': 'POS', 'spans': ['leuprolide', 'bicalutamide'], 'is_context_needed': True}]
To evaluate the efficacy and safety of lapatinib ( L ) and trastuzumab ( T ) combination in HER2-positive metastatic breast cancer ( MBC ) patients previously treated with T and/or L.	[{'class': 'POS', 'spans': ['lapatinib', 'trastuzumab'], 'is_context_needed': True}]
Meloxicam combined with sorafenib synergistically inhibits tumor growth of human hepatocellular carcinoma cells via ER stress-related apoptosis .	[{'class': 'POS', 'spans': ['Meloxicam', 'sorafenib'], 'is_context_needed': False}]
We validated these initial findings in samples collected in a clinical trial comparing the nucleoside analog fludarabine alone or in combination with the alkylating agent cyclophosphamide in untreated CLL samples collected prior to starting therapy ( E2997 ) .	[{'class': 'COMB', 'spans': ['fludarabine', 'cyclophosphamide'], 'is_context_needed': True}]
Cetuximab is a monoclonal antibody against EGFR with additive preclinical activity with irinotecan .	[{'class': 'POS', 'spans': ['Cetuximab', 'irinotecan'], 'is_context_needed': False}]
A non-specific inhibitor of 5-HT reuptake , imipramine , did not produce this amnesic effect , nor did the combination of fenfluramine with the MAOI tranylcypromine , although it produced , as expected , the " serotonergic syndrome . " Results for the metabolic precursor of 5-HT , 5-HTP , also administered peripherally , were inconsistent , with amnesic effects seen at 5 and 20 mg/kg but none at 10 mg/kg .	[{'class': 'NEG', 'spans': ['fenfluramine', 'tranylcypromine'], 'is_context_needed': False}]
Activity of irinotecan and temozolomide in the presence of O6-methylguanine-DNA methyltransferase inhibition in neuroblastoma pre-clinical models .	[{'class': 'POS', 'spans': ['irinotecan', 'temozolomide'], 'is_context_needed': True}]
This is a phase II study of etoposide , vincristine , and doxorubicin , administered as a 96-hour continuous infusion , with intravenous ( IV ) bolus cyclophosphamide and oral prednisone ( EPOCH ) in 74 consecutive patients who relapsed from or failed to respond to most of the same drugs administered on a bolus schedule .	[{'class': 'POS', 'spans': ['etoposide', 'vincristine', 'doxorubicin', 'cyclophosphamide', 'prednisone'], 'is_context_needed': True}]
Based on the FIRM-ACT trial , mitotane plus etoposide , doxorubicin , and cisplatin is now the established first-line cytotoxic therapy .	[{'class': 'POS', 'spans': ['mitotane', 'etoposide', 'doxorubicin', 'cisplatin'], 'is_context_needed': False}]
Consistent with previous reports , genistein combined with doxorubicin had a synergistic effect on MCF-7/Adr cells , and genistein reduced the chemoresistance of these cells .	[{'class': 'POS', 'spans': ['genistein', 'doxorubicin'], 'is_context_needed': False}]
Combination of ibrutinib and ublituximab ( n = 64 ) had an ORR of 78 % ( CR 7 % ) in a phase 3 study .	[{'class': 'POS', 'spans': ['ibrutinib', 'ublituximab'], 'is_context_needed': True}]
Paclitaxel , 5-fluorouracil , hydroxyurea , and concomitant radiation therapy for poor-prognosis head and neck cancer .	[{'class': 'NEG', 'spans': ['Paclitaxel', '5-fluorouracil', 'hydroxyurea'], 'is_context_needed': True}]
The results suggest that the superior efficacy of nivolumab plus ipilimumab over sunitinib was maintained in intermediate-risk or poor-risk and intention-to-treat patients with extended follow-up , and show the long-term benefits of nivolumab plus ipilimumab in patients with previously untreated advanced renal cell carcinoma across all risk categories .	[{'class': 'POS', 'spans': ['nivolumab', 'ipilimumab'], 'is_context_needed': False}]
A randomized trial of mobilization of peripheral blood stem cells with cyclophosphamide , etoposide , and granulocyte colony-stimulating factor with or without cisplatin in patients with malignant lymphoma receiving high-dose chemotherapy .	[{'class': 'NEG', 'spans': ['cyclophosphamide', 'etoposide', 'cisplatin'], 'is_context_needed': True}]
Treatment of pancreatic cancer with a combination of docetaxel , gemcitabine and granulocyte colony-stimulating factor : a phase II study of the Greek Cooperative Group for Pancreatic Cancer .	[{'class': 'POS', 'spans': ['docetaxel', 'gemcitabine'], 'is_context_needed': True}]
Such situations are known as exposing to pneumococcal meningitis and to resistance of the strain involved to penicillin G. Both patients were cured by vancomycin in continuous infusion associated with rifampicin or fosfomycin .	[{'class': 'POS', 'spans': ['vancomycin', 'rifampicin', 'fosfomycin'], 'is_context_needed': True}]
In 2011 , the combination of rituximab with bendamustine ( 31 % ) was most frequent used followed by the rituximab-fludarabine-cyclophosphamide ( 22 % ) regime .	[{'class': 'POS', 'spans': ['rituximab', 'bendamustine'], 'is_context_needed': True}]
The combination of ofatumumab and bendamustine in elderly patients with diffuse large B-cell lymphoma demonstrated modest efficacy compared with standard of care .	[{'class': 'POS', 'spans': ['ofatumumab', 'bendamustine'], 'is_context_needed': False}]
The most common chemotherapy and route of administration for systemic treatment is paclitaxel plus carboplatin given intravenously .	[{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': False}]
Aflibercept has been used in combination with folinic acid (leucovorin)-fluorouracil-irinotecan ( FOLFIRI ) chemotherapy in mCRC patients and among patients with mCRC with wild-type KRAS , the outcomes were significantly improved by panitumumab in combination with folinic acid (leucovorin)-fluorouracil-oxaliplatin ( FOLFOX ) or FOLFIRI .	[{'class': 'POS', 'spans': ['panitumumab', 'folinic acid'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 1], 'is_context_needed': True}]
The current mainstay of systemic treatment for patients with metastatic or unresectable disease remains doxorubicin with or without ifosfamide in the first-line setting .	[{'class': 'POS', 'spans': ['doxorubicin', 'ifosfamide'], 'is_context_needed': False}]
After an initial 6 - 8 weeks of metformin , they received either letrozole ( 2.5 mg ) or clomiphene ( 100 mg ) from day 3 - 7 of their menstrual cycle .	[{'class': 'POS', 'spans': ['metformin', 'letrozole'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}]
No study has evaluated the significance of CD30 expression in DLBCL patients treated with rituximab , etoposide , prednisone , vincristine , cyclophosphamide , and doxorubicin ( R-EPOCH ) .	[{'class': 'COMB', 'spans': ['rituximab', 'etoposide', 'prednisone', 'vincristine', 'cyclophosphamide', 'doxorubicin'], 'is_context_needed': True}]
Suggested evidence linking the association of the drug to the event includes knowing that Panitumumab and Irinotecan can contribute to all other possible causes of cardiac arrest , temporal relationship and pharmacological time plausibility , and recognized association with the product or the class .	[{'class': 'NEG', 'spans': ['Panitumumab', 'Irinotecan'], 'is_context_needed': False}]
Cyclophosphamide , mitoxantrone , fluorouracil versus conventional CMF as adjuvant treatment in node-positive breast cancer patients .	[{'class': 'POS', 'spans': ['Cyclophosphamide', 'mitoxantrone', 'fluorouracil'], 'is_context_needed': True}]
After the operation , an alternating vincristine , doxorubicin , and cyclophosphamide/ifosfamide and etoposide ( IE ) regimen was given for eight cycles , and the patient survived for 66 mo without progression .	[{'class': 'POS', 'spans': ['vincristine', 'doxorubicin', 'etoposide'], 'is_context_needed': False}]
A total of 34 patients with androgen-independent prostate cancer received doxorubicin , 30 mg/m(2 ) , every 2 weeks and ketoconazole daily , 400 mg orally every 8 hours .	[{'class': 'POS', 'spans': ['doxorubicin', 'ketoconazole'], 'is_context_needed': True}]
Three first-line drugs are recommended , pegylated interferon alfa-2a , entecavir and tenofovir .	[{'class': 'POS', 'spans': ['pegylated interferon alfa-2a', 'entecavir', 'tenofovir'], 'is_context_needed': False}]
A phase 1/2 trial of tivozanib in combination with durvalumab is currently underway .	[{'class': 'POS', 'spans': ['tivozanib', 'durvalumab'], 'is_context_needed': True}]
Health-related quality of life of patients with advanced breast cancer treated with everolimus plus exemestane versus placebo plus exemestane in the phase 3 , randomized , controlled , BOLERO-2 trial .	[{'class': 'POS', 'spans': ['everolimus', 'exemestane'], 'is_context_needed': True}]
Phase 2 study of irinotecan and paclitaxel in patients with recurrent or refractory small cell lung cancer .	[{'class': 'POS', 'spans': ['irinotecan', 'paclitaxel'], 'is_context_needed': True}]
This was a multicenter phase II pilot study of rituximab and modified hyper-fractionated cyclophosphamide , vincristine doxorubicin , dexamethasone ( modified R-hyperCVAD ) administered every 28 days for four to six cycles followed by rituximab maintenance therapy consisting of four weekly doses every 6 months for 2 years .	[{'class': 'POS', 'spans': ['rituximab', 'cyclophosphamide', 'vincristine', 'doxorubicin', 'dexamethasone'], 'is_context_needed': True}]
This trial will close to accrual in September 1995 , and analysis of the trial should provide useful information regarding the potential synergy of doxorubicin and paclitaxel , the degree of cross-resistance between the two compounds , and the relationship between steady-state paclitaxel levels and response to therapy .	[{'class': 'POS', 'spans': ['doxorubicin', 'paclitaxel'], 'is_context_needed': False}]
26 patients received adjuvant chemotherapy ( carboplatin plus etoposide ) .	[{'class': 'POS', 'spans': ['carboplatin', 'etoposide'], 'is_context_needed': True}]
A concentration-dependent effect of venetoclax on PFS and a prolonged synergistic effect of 6 cycles of concomitant rituximab were identified .	[{'class': 'POS', 'spans': ['venetoclax', 'rituximab'], 'is_context_needed': False}]
Carboplatin plus taxanes are non-inferior to epirubicin plus cyclophosphamide followed by taxanes as adjuvant chemotherapy for early triple-negative breast cancer .	[{'class': 'POS', 'spans': ['Carboplatin', 'taxanes'], 'is_context_needed': False}, {'class': 'COMB', 'spans': [2, 3], 'is_context_needed': True}]
Comparative study of ceftriaxone monotherapy versus a combination regimen of cefuroxime plus gentamicin for treatment of serious bacterial infections : the efficacy , safety and effect on fecal flora .	[{'class': 'NEG', 'spans': ['cefuroxime', 'gentamicin'], 'is_context_needed': True}]
A phase 1b , dose escalation study was performed to assess maximum tolerated dose , safety/toxicity , clinical efficacy and explored pharmacodynamic biomarkers of response to entinostat combined with lapatinib with or without trastuzumab .	[{'class': 'POS', 'spans': ['entinostat', 'lapatinib', 'trastuzumab'], 'is_context_needed': True}]
Objective and palliative effect of chemotherapy is marked for weekly doxorubicin , prednisone with mitoxantrone and etoposide associated with platin-salts for prostatic carcinoma with neuroendocrine differentiation .	[{'class': 'COMB', 'spans': ['doxorubicin', 'prednisone', 'mitoxantrone', 'etoposide'], 'is_context_needed': True}]
The recommendations derived from the comprehensive assessment of the literature and guidelines are to continue NSAIDs and low dose aspirin , and phosphodiesterase inhibitors ( dipyridamole , cilostazol , Aggrenox ) during interventional techniques .	[{'class': 'POS', 'spans': ['aspirin', 'dipyridamole'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}]
Enhanced growth-inhibiting effects were also observed in HCC cells treated with a combination of sorafenib and silibinin .	[{'class': 'POS', 'spans': ['sorafenib', 'silibinin'], 'is_context_needed': False}]
The effects of the Acanthopanax obovatus polysaccharide ( AOPS ) as well as its combination with cyclophosphamide ( CY ) or prednisolone on immune responses were investigated in mice .	[{'class': 'POS', 'spans': ['Acanthopanax obovatus polysaccharide', 'cyclophosphamide'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': True}]
We did the QuiRedex study to compare early treatment with lenalidomide plus dexamethasone with observation in patients with high-risk smouldering multiple myeloma .	[{'class': 'POS', 'spans': ['lenalidomide', 'dexamethasone'], 'is_context_needed': True}]
Of the patients , 26 were treated with a chemotherapy regimen known to cause prolonged and sometimes permanent azoospermia ( BEACOPP -- bleomycin , etoposide , doxorubicin , cyclophosphamide , vincristine , procarbazine , and prednisolone ) and 26 with a regimen known to have a much milder effect on gonadal function ( ABVD -- doxorubicin , bleomycin , vincristine , and dacarbazine ) .	[{'class': 'POS', 'spans': ['bleomycin', 'vincristine', 'dacarbazine', 'doxorubicin'], 'is_context_needed': False}, {'class': 'NEG', 'spans': [0, 1, 2, 3, 4, 5, 6], 'is_context_needed': False}]
Tissue from preclinical models and patients ' biopsies were collected pre-treatment and on Cycle ( C ) 1 , Day ( D ) 9 to characterize the effect of gemcitabine and salirasib on activated Ras protein levels .	[{'class': 'POS', 'spans': ['gemcitabine', 'salirasib'], 'is_context_needed': True}]
The effect of dasatinib , an inhibitor of Src and Abl kinases , on paclitaxel sensitivity was measured in ovarian cancer cells and HEY xenografts .	[{'class': 'POS', 'spans': ['dasatinib', 'paclitaxel'], 'is_context_needed': True}]
The maximum tolerated dose ( MTD ) was 20 mg/m2/day I.V. bolus for 5 days of fludarabine plus 60 mg/m2/day I.V. of paclitaxel given as a continuous infusion over 72 hours .	[{'class': 'POS', 'spans': ['fludarabine', 'paclitaxel'], 'is_context_needed': True}]
Further studies are needed to identify predictors of response and toxicity to this approach , as well as the optimal scheduling of ipilimumab with maintenance nivolumab .	[{'class': 'POS', 'spans': ['ipilimumab', 'nivolumab'], 'is_context_needed': True}]
Efficacy of palonosetron plus aprepitant in preventing chemoradiotherapy-induced nausea and emesis in patients receiving daily low-dose cisplatin-based concurrent chemoradiotherapy for uterine cervical cancer : a phase II study .	[{'class': 'POS', 'spans': ['palonosetron', 'aprepitant'], 'is_context_needed': True}]
Pre/peri/postmenopausal women with HR+/HER2- MBC were randomized 2:1 to fulvestrant ( 500 mg ) and either palbociclib ( 125 mg/day ; 3 weeks on/1 week off ; n = 347 ) or placebo ( n = 174 ) . Prespecified exploratory analyses compared the efficacy ( data cutoff : October 23 , 2015 ) , safety , and pharmacokinetics ( data cutoff : December 5 , 2014 ) in Japanese women versus the overall population .	[{'class': 'POS', 'spans': ['fulvestrant', 'palbociclib'], 'is_context_needed': True}]
was lowest in the propofol + dexmedetomidine group ( all , P < 0.05 ) , and the AUC of pulse oximetry was significantly higher in the propofol + dexmedetomidine and propofol + ketamine groups compared to the other 2 groups ( both , P < 0.05 ) .	[{'class': 'POS', 'spans': ['propofol', 'ketamine'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 1, 2, 3], 'is_context_needed': True}]
Patients aged 15 to 60 years , presenting with newly diagnosed acute myeloid leukemia ( AML ) were randomized to receive either high-dose cytarabine , 3 g/m2 12 hourly on days 1 , 3 , 5 , and 7 for 8 doses , daunorubicin 50 mg/m2 days 1 to 3 , etoposide 75 mg/m2 days 1 to 7 , ( HIDAC-3 - 7 ) or standard dose cytarabine 100 mg/m2 continuous intravenous infusion for 7 days with daunorubicin and etoposide at the same dose and schedule as above ( 7 - 3 - 7 ) .	[{'class': 'COMB', 'spans': ['cytarabine', 'daunorubicin', 'etoposide'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [3, 4, 5], 'is_context_needed': True}]
Therefore , if a combination regimen is necessary to control CMV in a patient , foscarnet and ganciclovir should be used first .	[{'class': 'POS', 'spans': ['foscarnet', 'ganciclovir'], 'is_context_needed': False}]
A Phase Ib/II Study of Afatinib in Combination with Nimotuzumab in Non-Small Cell Lung Cancer Patients with Acquired Resistance to Gefitinib or Erlotinib .	[{'class': 'POS', 'spans': ['Afatinib', 'Nimotuzumab'], 'is_context_needed': True}]
RESULTS In first-line treatment , compared with sunitinib , improvement of one-year CPFS for the nivolumab plus ipilimumab group after living for 0.5 and 0.75 years were 14 % ( from 53.0 % to 67.0 % ) and 16 % ( from 57.0 % to 73.0 % ) higher than the one-year PFS of 6.5 % ( from 42.9 % to 49.4 % ) , with similar results for one-year COS following first-line treatment .	[{'class': 'POS', 'spans': ['nivolumab', 'ipilimumab'], 'is_context_needed': True}]
This study analysed 126 patients with relapsed , advanced stage follicular lymphoma who received BEAM ( BCNU [ carmustine ] , cytarabine , etoposide , melphalan)-alemtuzumab allogeneic HSCT ( BEAM-allo ) ( n = 44 ) or BEAM-autologous HSCT ( BEAM-auto ) ( n = 82 ) .	[{'class': 'COMB', 'spans': ['carmustine', 'cytarabine', 'etoposide', 'melphalan)-alemtuzumab'], 'is_context_needed': True}]
Apixaban and rivaroxaban were evaluated in phase III trials for prevention of recurrent ischaemia in ACS patients , most of whom were also receiving dual antiplatelet therapy with aspirin and clopidogrel .	[{'class': 'COMB', 'spans': ['aspirin', 'clopidogrel'], 'is_context_needed': True}]
Furthermore , VPA significantly increased chemosensitivity to fludarabine , flavopiridol , bortezomib , thalidomide and lenalidomide .	[{'class': 'POS', 'spans': ['VPA', 'fludarabine'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 3], 'is_context_needed': False}]
Use of the tumor-infiltrating CD8 to FOXP3 lymphocyte ratio in predicting treatment responses to combination therapy with pertuzumab , trastuzumab , and docetaxel for advanced HER2-positive breast cancer .	[{'class': 'POS', 'spans': ['pertuzumab', 'trastuzumab', 'docetaxel'], 'is_context_needed': True}]
The clinical symptoms were relieved after combination of doxycycline , rifampicin , levofloxacin and amikacin for 6 weeks , only one patient with bone destruction needed orthopedic surgery .	[{'class': 'POS', 'spans': ['doxycycline', 'rifampicin', 'levofloxacin', 'amikacin'], 'is_context_needed': False}]
Four years after surgery , she experienced a recurrence of breast cancer in the thoracic wall , and was treated with exemestane , toremifene , and fulvestrant for 1 year and 5 months .	[{'class': 'COMB', 'spans': ['exemestane', 'toremifene', 'fulvestrant'], 'is_context_needed': True}]
Long-term efficacy of doxazosin plus atenolol in the management of severe and sustained arterial hypertension and reversibility of the cardiac damage induced by chronic cathecolamine excess .	[{'class': 'POS', 'spans': ['doxazosin', 'atenolol'], 'is_context_needed': True}]
To evaluate the use of low-molecular-weight heparin ( LMWH ) in combination with low-dose aspirin ( LDA ) for the treatment of antiphospholipid antibody (APA)-associated recurrent pregnancy loss and to compare the results with the use of unfractionated heparin ( UFH ) plus LDA .	[{'class': 'POS', 'spans': ['low-molecular-weight heparin', 'aspirin'], 'is_context_needed': True}]
Therefore , the pain scores were significantly higher in the neostigmine group than the other two groups ( p = 0.02 ) , but no significant difference was found between the two groups that received dexmedetomidine and a combination of dexmedetomidine + neostigmine .	[{'class': 'POS', 'spans': ['dexmedetomidine', 'neostigmine'], 'is_context_needed': True}]
[ Two cases of complete response to combination chemotherapy of gemcitabine and docetaxel for recurrent ovarian cancer ] .	[{'class': 'POS', 'spans': ['gemcitabine', 'docetaxel'], 'is_context_needed': False}]
Hormonal changes in postmenopausal women with breast cancer treated with trilostane and dexamethasone .	[{'class': 'COMB', 'spans': ['trilostane', 'dexamethasone'], 'is_context_needed': True}]
After surgical insertion of a catheter in the hepatic artery , patients were treated with oxaliplatin 100 mg/m(2 ) HAI combined with FU + leucovorin IV according to the LV5FU2 protocol .	[{'class': 'POS', 'spans': ['oxaliplatin', 'leucovorin'], 'is_context_needed': True}]
Then , doxorubicin with or without flavopiridol was injected .	[{'class': 'POS', 'spans': ['doxorubicin', 'flavopiridol'], 'is_context_needed': True}]
Subjects were treated in two cycles , 3 months apart , in which they received bicalutamide 150 mg daily days 1 - 28 and tremelimumab on day 29 .	[{'class': 'COMB', 'spans': ['bicalutamide', 'tremelimumab'], 'is_context_needed': True}]
This study examines a novel regimen utilizing the combination of epidurally infused ropivacaine - hydromorphone and scheduled ketorolac .	[{'class': 'POS', 'spans': ['ropivacaine', 'hydromorphone', 'ketorolac'], 'is_context_needed': True}]
Patients in the HXP arm also received trastuzumab ( 8 mg/kg intravenous infusion on Day 1 ) , concurrently with capecitabine .	[{'class': 'COMB', 'spans': ['trastuzumab', 'capecitabine'], 'is_context_needed': True}]
Among targeted therapies , lapatinib has activity in systemic treatment of BM particularly when used in combination with capecitabine .	[{'class': 'POS', 'spans': ['lapatinib', 'capecitabine'], 'is_context_needed': False}]
An in vitro assessment of azithromycin in combination with gentamicin demonstrated inhibition of growth and suggests that clinical trials may be warranted to assess the utility of this combination in treating gonorrhea infections .	[{'class': 'POS', 'spans': ['azithromycin', 'gentamicin'], 'is_context_needed': False}]

Inflammatory breast cancer ( IBC ) is a rare , aggressive form of breast cancer associated with HER2 amplification , with high risk of metastasis and an estimated median survival of 2.9 y. We performed an open-label , single-arm phase II clinical trial ( ClinicalTrials.gov NCT01325428 ) to investigate the efficacy and safety of afatinib , an irreversible ErbB family inhibitor , alone and in combination with vinorelbine in patients with HER2-positive IBC .

[{'class': 'POS', 'spans': ['afatinib', 'vinorelbine'], 'is_context_needed': True}]

Carboplatin and paclitaxel versus cisplatin , paclitaxel and doxorubicin for first-line chemotherapy of advanced ovarian cancer : a Hellenic Cooperative Oncology Group ( HeCOG ) study .

[{'class': 'POS', 'spans': ['Carboplatin', 'paclitaxel'], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 3, 4], 'is_context_needed': True}]

For susceptibility testing , DS-8587 exhibited more effective antibacterial activity when compared with ciprofloxacin and levofloxacin .

[{'class': 'NEG', 'spans': ['ciprofloxacin', 'levofloxacin'], 'is_context_needed': False}]

Since 1987 , we have evaluated carboplatin alone or in combination with etoposide in two separate phase II trials of patients with non-small cell lung cancer ( NSCLC ) who had not received prior chemotherapy .

[{'class': 'COMB', 'spans': ['carboplatin', 'etoposide'], 'is_context_needed': True}]

FLAIE ( fludarabine , cytarabine , idarubicin , and etoposide ) , a four drug induction chemotherapy for adult acute myeloid leukemia : A single center experience .

[{'class': 'COMB', 'spans': ['fludarabine', 'cytarabine', 'idarubicin', 'etoposide'], 'is_context_needed': True}]

Overall , our study shows that the combination of dabrafenib and cetuximab results in increased antitumor activity and decreased stem cell capacities in BRAF(V600E)-mutant CRC cells .

[{'class': 'POS', 'spans': ['dabrafenib', 'cetuximab'], 'is_context_needed': False}]

Forty-seven patients with previously untreated metastatic or unresectable colorectal adenocarcinoma received capecitabine 1000 mg/m2 twice daily on days 2 - 15 and intravenous irinotecan 100 mg/m2 on days 1 and 8 , every 21 days .

[{'class': 'POS', 'spans': ['capecitabine', 'irinotecan'], 'is_context_needed': True}]

Amphotericin B plus flucytosine were initially given to 4 patients , all of them developed liver and renal abnormalities to some degree after therapy .

[{'class': 'NEG', 'spans': ['Amphotericin', 'flucytosine'], 'is_context_needed': False}]

Liposomes were surface modified with transferrin ( Tf ) for receptor targeting , and cell penetrating peptide PFVYLI ( PFV ) to increase translocation of doxorubicin ( Dox ) and Erlotinib ( Erlo ) across the BBB into glioblastoma ( U87 ) tumor cells .

[{'class': 'POS', 'spans': ['doxorubicin', 'Erlotinib'], 'is_context_needed': True}]

Endpoints were determination of maximum tolerated dose of doxorubicin and etoposide , treatment tolerability , and survival .

[{'class': 'POS', 'spans': ['doxorubicin', 'etoposide'], 'is_context_needed': True}]

Multiple ongoing clinical trials are currently evaluating the role of immune checkpoint inhibitors in ACC ( pembrolizumab , combination pembrolizumab and relacorilant , nivolumab , combination nivolumab and ipilimumab ) .

[{'class': 'COMB', 'spans': ['pembrolizumab', 'relacorilant'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [4, 5], 'is_context_needed': True}]

Bevacizumab and intetumumab can be administered safely in combination .

[{'class': 'POS', 'spans': ['Bevacizumab', 'intetumumab'], 'is_context_needed': False}]

The protocol consisted of oral gefitinib 250 mg daily for 1 year plus intravenous oxaliplatin 85 or 100 mg/m(2 ) on days 1 , 15 , and 29 , and RT ( 50.4 Gy in 28 1.8-Gy fractions ) .

[{'class': 'COMB', 'spans': ['gefitinib', 'oxaliplatin'], 'is_context_needed': True}]

Forty-eight patients were treated with mitoxantrone alone , 40 with mitoxantrone plus beta-interferon , 11 with fluorouracil plus folinic acid and the remaining four with adriamycin .

[{'class': 'COMB', 'spans': ['mitoxantrone', 'beta-interferon'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [2, 3], 'is_context_needed': True}]

Fifty-one HIV-negative patients with an average age of 50.3 years were treated with chemotherapy regimen included 2500 mg/m(2 ) MTX with Leucovorin rescue and 1.4 mg/m(2 ) vincristine ( day two ) , which was administered every other week for 6 weeks .

[{'class': 'COMB', 'spans': ['Leucovorin', 'vincristine'], 'is_context_needed': True}]

Phase I study of decitabine with doxorubicin and cyclophosphamide in children with neuroblastoma and other solid tumors : a Children 's Oncology Group study .

[{'class': 'NEG', 'spans': ['decitabine', 'doxorubicin'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [0, 2], 'is_context_needed': True}]

Our study involves a preliminary phase II trial , which evaluates the activity , feasibility and tolerability of a sequential combination of docetaxel and gemcitabine followed by docetaxel and carboplatin , as first-line treatment for inoperable NSCLC .

[{'class': 'POS', 'spans': ['docetaxel', 'gemcitabine', 'carboplatin'], 'is_context_needed': True}]

The combination of galunisertib and sorafenib showed acceptable safety and a prolonged OS outcome .

[{'class': 'POS', 'spans': ['galunisertib', 'sorafenib'], 'is_context_needed': False}]

All the patients were conditioned with busulfan ( BU ) 12 mg.kg-1 and cyclophosphamide ( CY ) 3.6 g.m-2 , of whom 4 were conditioned with additioned antithymocyte globulin(ATG ) .

[{'class': 'POS', 'spans': ['busulfan', 'cyclophosphamide', 'antithymocyte globulin(ATG'], 'is_context_needed': True}]

Phase II study of an intensive combination chemotherapy with cisplatin , adriamycin , etoposide and cyclophosphamide ( CAVE ) in small cell lung cancer .

[{'class': 'POS', 'spans': ['cisplatin', 'adriamycin', 'etoposide', 'cyclophosphamide'], 'is_context_needed': False}]

Simultaneous treatment with gefitinib and pemetrexed enhanced cell growth inhibition and cell death and prevented the appearance of gefitinib resistance mediated by T790 M mutation or epithelial-to-mesenchymal transition ( EMT ) in PC9 and HCC827 cells , respectively .

[{'class': 'POS', 'spans': ['gefitinib', 'pemetrexed'], 'is_context_needed': False}]

Two courses of eight drugs in 1 day followed by two courses of etoposide plus carboplatin ( 500 and 800 mg/m(2 ) per course , respectively ) were administered after surgery .

[{'class': 'POS', 'spans': ['etoposide', 'carboplatin'], 'is_context_needed': True}]

3 . When timolol was administered concomitantly with hydrochlorothiazide , plasma renin activity was suppressed and blood pressure was significantly lowered .

[{'class': 'POS', 'spans': ['timolol', 'hydrochlorothiazide'], 'is_context_needed': False}]

Phase I study combining treatment with temsirolimus and sunitinib malate in patients with advanced renal cell carcinoma .

[{'class': 'NEG', 'spans': ['temsirolimus', 'sunitinib'], 'is_context_needed': True}]

2 . The two combination treatment regimes lowered the 12 h post-dose blood pressure more effectively than did atenolol alone , but the high dose nifedipine combination was no more effective than the low dose nifedipine combination .

[{'class': 'POS', 'spans': ['atenolol', 'nifedipine'], 'is_context_needed': True}]

Low-risk patients received three cycles of modified CODOX-M ( cyclophosphamide , doxorubicin , adriamycin , vincristine with intrathecal methotrexate and cytarabine followed by high-dose systemic methotrexate , regimen A ) .

[{'class': 'POS', 'spans': ['cyclophosphamide', 'doxorubicin', 'vincristine', 'methotrexate', 'cytarabine', 'adriamycin'], 'is_context_needed': True}]

Background The National Wilms Tumor Study ( NWTS ) approach to treating stage III favorable-histology Wilms tumor ( FHWT ) is Regimen DD4A ( vincristine , dactinomycin , and doxorubicin ) and radiation therapy .

[{'class': 'POS', 'spans': ['vincristine', 'doxorubicin', 'dactinomycin'], 'is_context_needed': True}]

Enrolled patients received ADT in the form of leuprolide every 12 weeks for 24 months with bicalutamide initiating after the completion of chemotherapy .

[{'class': 'POS', 'spans': ['leuprolide', 'bicalutamide'], 'is_context_needed': True}]

To evaluate the efficacy and safety of lapatinib ( L ) and trastuzumab ( T ) combination in HER2-positive metastatic breast cancer ( MBC ) patients previously treated with T and/or L.

[{'class': 'POS', 'spans': ['lapatinib', 'trastuzumab'], 'is_context_needed': True}]

Meloxicam combined with sorafenib synergistically inhibits tumor growth of human hepatocellular carcinoma cells via ER stress-related apoptosis .

[{'class': 'POS', 'spans': ['Meloxicam', 'sorafenib'], 'is_context_needed': False}]

We validated these initial findings in samples collected in a clinical trial comparing the nucleoside analog fludarabine alone or in combination with the alkylating agent cyclophosphamide in untreated CLL samples collected prior to starting therapy ( E2997 ) .

[{'class': 'COMB', 'spans': ['fludarabine', 'cyclophosphamide'], 'is_context_needed': True}]

Cetuximab is a monoclonal antibody against EGFR with additive preclinical activity with irinotecan .

[{'class': 'POS', 'spans': ['Cetuximab', 'irinotecan'], 'is_context_needed': False}]

A non-specific inhibitor of 5-HT reuptake , imipramine , did not produce this amnesic effect , nor did the combination of fenfluramine with the MAOI tranylcypromine , although it produced , as expected , the " serotonergic syndrome . " Results for the metabolic precursor of 5-HT , 5-HTP , also administered peripherally , were inconsistent , with amnesic effects seen at 5 and 20 mg/kg but none at 10 mg/kg .

[{'class': 'NEG', 'spans': ['fenfluramine', 'tranylcypromine'], 'is_context_needed': False}]

Activity of irinotecan and temozolomide in the presence of O6-methylguanine-DNA methyltransferase inhibition in neuroblastoma pre-clinical models .

[{'class': 'POS', 'spans': ['irinotecan', 'temozolomide'], 'is_context_needed': True}]

This is a phase II study of etoposide , vincristine , and doxorubicin , administered as a 96-hour continuous infusion , with intravenous ( IV ) bolus cyclophosphamide and oral prednisone ( EPOCH ) in 74 consecutive patients who relapsed from or failed to respond to most of the same drugs administered on a bolus schedule .

[{'class': 'POS', 'spans': ['etoposide', 'vincristine', 'doxorubicin', 'cyclophosphamide', 'prednisone'], 'is_context_needed': True}]

Based on the FIRM-ACT trial , mitotane plus etoposide , doxorubicin , and cisplatin is now the established first-line cytotoxic therapy .

[{'class': 'POS', 'spans': ['mitotane', 'etoposide', 'doxorubicin', 'cisplatin'], 'is_context_needed': False}]

Consistent with previous reports , genistein combined with doxorubicin had a synergistic effect on MCF-7/Adr cells , and genistein reduced the chemoresistance of these cells .

[{'class': 'POS', 'spans': ['genistein', 'doxorubicin'], 'is_context_needed': False}]

Combination of ibrutinib and ublituximab ( n = 64 ) had an ORR of 78 % ( CR 7 % ) in a phase 3 study .

[{'class': 'POS', 'spans': ['ibrutinib', 'ublituximab'], 'is_context_needed': True}]

Paclitaxel , 5-fluorouracil , hydroxyurea , and concomitant radiation therapy for poor-prognosis head and neck cancer .

[{'class': 'NEG', 'spans': ['Paclitaxel', '5-fluorouracil', 'hydroxyurea'], 'is_context_needed': True}]

The results suggest that the superior efficacy of nivolumab plus ipilimumab over sunitinib was maintained in intermediate-risk or poor-risk and intention-to-treat patients with extended follow-up , and show the long-term benefits of nivolumab plus ipilimumab in patients with previously untreated advanced renal cell carcinoma across all risk categories .

[{'class': 'POS', 'spans': ['nivolumab', 'ipilimumab'], 'is_context_needed': False}]

A randomized trial of mobilization of peripheral blood stem cells with cyclophosphamide , etoposide , and granulocyte colony-stimulating factor with or without cisplatin in patients with malignant lymphoma receiving high-dose chemotherapy .

[{'class': 'NEG', 'spans': ['cyclophosphamide', 'etoposide', 'cisplatin'], 'is_context_needed': True}]

Treatment of pancreatic cancer with a combination of docetaxel , gemcitabine and granulocyte colony-stimulating factor : a phase II study of the Greek Cooperative Group for Pancreatic Cancer .

[{'class': 'POS', 'spans': ['docetaxel', 'gemcitabine'], 'is_context_needed': True}]

Such situations are known as exposing to pneumococcal meningitis and to resistance of the strain involved to penicillin G. Both patients were cured by vancomycin in continuous infusion associated with rifampicin or fosfomycin .

[{'class': 'POS', 'spans': ['vancomycin', 'rifampicin', 'fosfomycin'], 'is_context_needed': True}]

In 2011 , the combination of rituximab with bendamustine ( 31 % ) was most frequent used followed by the rituximab-fludarabine-cyclophosphamide ( 22 % ) regime .

[{'class': 'POS', 'spans': ['rituximab', 'bendamustine'], 'is_context_needed': True}]

The combination of ofatumumab and bendamustine in elderly patients with diffuse large B-cell lymphoma demonstrated modest efficacy compared with standard of care .

[{'class': 'POS', 'spans': ['ofatumumab', 'bendamustine'], 'is_context_needed': False}]

The most common chemotherapy and route of administration for systemic treatment is paclitaxel plus carboplatin given intravenously .

[{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': False}]

Aflibercept has been used in combination with folinic acid (leucovorin)-fluorouracil-irinotecan ( FOLFIRI ) chemotherapy in mCRC patients and among patients with mCRC with wild-type KRAS , the outcomes were significantly improved by panitumumab in combination with folinic acid (leucovorin)-fluorouracil-oxaliplatin ( FOLFOX ) or FOLFIRI .

[{'class': 'POS', 'spans': ['panitumumab', 'folinic acid'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 1], 'is_context_needed': True}]

The current mainstay of systemic treatment for patients with metastatic or unresectable disease remains doxorubicin with or without ifosfamide in the first-line setting .

[{'class': 'POS', 'spans': ['doxorubicin', 'ifosfamide'], 'is_context_needed': False}]

After an initial 6 - 8 weeks of metformin , they received either letrozole ( 2.5 mg ) or clomiphene ( 100 mg ) from day 3 - 7 of their menstrual cycle .

[{'class': 'POS', 'spans': ['metformin', 'letrozole'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}]

No study has evaluated the significance of CD30 expression in DLBCL patients treated with rituximab , etoposide , prednisone , vincristine , cyclophosphamide , and doxorubicin ( R-EPOCH ) .

[{'class': 'COMB', 'spans': ['rituximab', 'etoposide', 'prednisone', 'vincristine', 'cyclophosphamide', 'doxorubicin'], 'is_context_needed': True}]

Suggested evidence linking the association of the drug to the event includes knowing that Panitumumab and Irinotecan can contribute to all other possible causes of cardiac arrest , temporal relationship and pharmacological time plausibility , and recognized association with the product or the class .

[{'class': 'NEG', 'spans': ['Panitumumab', 'Irinotecan'], 'is_context_needed': False}]

Cyclophosphamide , mitoxantrone , fluorouracil versus conventional CMF as adjuvant treatment in node-positive breast cancer patients .

[{'class': 'POS', 'spans': ['Cyclophosphamide', 'mitoxantrone', 'fluorouracil'], 'is_context_needed': True}]

After the operation , an alternating vincristine , doxorubicin , and cyclophosphamide/ifosfamide and etoposide ( IE ) regimen was given for eight cycles , and the patient survived for 66 mo without progression .

[{'class': 'POS', 'spans': ['vincristine', 'doxorubicin', 'etoposide'], 'is_context_needed': False}]

A total of 34 patients with androgen-independent prostate cancer received doxorubicin , 30 mg/m(2 ) , every 2 weeks and ketoconazole daily , 400 mg orally every 8 hours .

[{'class': 'POS', 'spans': ['doxorubicin', 'ketoconazole'], 'is_context_needed': True}]

Three first-line drugs are recommended , pegylated interferon alfa-2a , entecavir and tenofovir .

[{'class': 'POS', 'spans': ['pegylated interferon alfa-2a', 'entecavir', 'tenofovir'], 'is_context_needed': False}]

A phase 1/2 trial of tivozanib in combination with durvalumab is currently underway .

[{'class': 'POS', 'spans': ['tivozanib', 'durvalumab'], 'is_context_needed': True}]

Health-related quality of life of patients with advanced breast cancer treated with everolimus plus exemestane versus placebo plus exemestane in the phase 3 , randomized , controlled , BOLERO-2 trial .

[{'class': 'POS', 'spans': ['everolimus', 'exemestane'], 'is_context_needed': True}]

Phase 2 study of irinotecan and paclitaxel in patients with recurrent or refractory small cell lung cancer .

[{'class': 'POS', 'spans': ['irinotecan', 'paclitaxel'], 'is_context_needed': True}]

This was a multicenter phase II pilot study of rituximab and modified hyper-fractionated cyclophosphamide , vincristine doxorubicin , dexamethasone ( modified R-hyperCVAD ) administered every 28 days for four to six cycles followed by rituximab maintenance therapy consisting of four weekly doses every 6 months for 2 years .

[{'class': 'POS', 'spans': ['rituximab', 'cyclophosphamide', 'vincristine', 'doxorubicin', 'dexamethasone'], 'is_context_needed': True}]

This trial will close to accrual in September 1995 , and analysis of the trial should provide useful information regarding the potential synergy of doxorubicin and paclitaxel , the degree of cross-resistance between the two compounds , and the relationship between steady-state paclitaxel levels and response to therapy .

[{'class': 'POS', 'spans': ['doxorubicin', 'paclitaxel'], 'is_context_needed': False}]

26 patients received adjuvant chemotherapy ( carboplatin plus etoposide ) .

[{'class': 'POS', 'spans': ['carboplatin', 'etoposide'], 'is_context_needed': True}]

A concentration-dependent effect of venetoclax on PFS and a prolonged synergistic effect of 6 cycles of concomitant rituximab were identified .

[{'class': 'POS', 'spans': ['venetoclax', 'rituximab'], 'is_context_needed': False}]

Carboplatin plus taxanes are non-inferior to epirubicin plus cyclophosphamide followed by taxanes as adjuvant chemotherapy for early triple-negative breast cancer .

[{'class': 'POS', 'spans': ['Carboplatin', 'taxanes'], 'is_context_needed': False}, {'class': 'COMB', 'spans': [2, 3], 'is_context_needed': True}]

Comparative study of ceftriaxone monotherapy versus a combination regimen of cefuroxime plus gentamicin for treatment of serious bacterial infections : the efficacy , safety and effect on fecal flora .

[{'class': 'NEG', 'spans': ['cefuroxime', 'gentamicin'], 'is_context_needed': True}]

A phase 1b , dose escalation study was performed to assess maximum tolerated dose , safety/toxicity , clinical efficacy and explored pharmacodynamic biomarkers of response to entinostat combined with lapatinib with or without trastuzumab .

[{'class': 'POS', 'spans': ['entinostat', 'lapatinib', 'trastuzumab'], 'is_context_needed': True}]

Objective and palliative effect of chemotherapy is marked for weekly doxorubicin , prednisone with mitoxantrone and etoposide associated with platin-salts for prostatic carcinoma with neuroendocrine differentiation .

[{'class': 'COMB', 'spans': ['doxorubicin', 'prednisone', 'mitoxantrone', 'etoposide'], 'is_context_needed': True}]

The recommendations derived from the comprehensive assessment of the literature and guidelines are to continue NSAIDs and low dose aspirin , and phosphodiesterase inhibitors ( dipyridamole , cilostazol , Aggrenox ) during interventional techniques .

[{'class': 'POS', 'spans': ['aspirin', 'dipyridamole'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}]

Enhanced growth-inhibiting effects were also observed in HCC cells treated with a combination of sorafenib and silibinin .

[{'class': 'POS', 'spans': ['sorafenib', 'silibinin'], 'is_context_needed': False}]

The effects of the Acanthopanax obovatus polysaccharide ( AOPS ) as well as its combination with cyclophosphamide ( CY ) or prednisolone on immune responses were investigated in mice .

[{'class': 'POS', 'spans': ['Acanthopanax obovatus polysaccharide', 'cyclophosphamide'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': True}]

We did the QuiRedex study to compare early treatment with lenalidomide plus dexamethasone with observation in patients with high-risk smouldering multiple myeloma .

[{'class': 'POS', 'spans': ['lenalidomide', 'dexamethasone'], 'is_context_needed': True}]

Of the patients , 26 were treated with a chemotherapy regimen known to cause prolonged and sometimes permanent azoospermia ( BEACOPP -- bleomycin , etoposide , doxorubicin , cyclophosphamide , vincristine , procarbazine , and prednisolone ) and 26 with a regimen known to have a much milder effect on gonadal function ( ABVD -- doxorubicin , bleomycin , vincristine , and dacarbazine ) .

[{'class': 'POS', 'spans': ['bleomycin', 'vincristine', 'dacarbazine', 'doxorubicin'], 'is_context_needed': False}, {'class': 'NEG', 'spans': [0, 1, 2, 3, 4, 5, 6], 'is_context_needed': False}]

Tissue from preclinical models and patients ' biopsies were collected pre-treatment and on Cycle ( C ) 1 , Day ( D ) 9 to characterize the effect of gemcitabine and salirasib on activated Ras protein levels .

[{'class': 'POS', 'spans': ['gemcitabine', 'salirasib'], 'is_context_needed': True}]

The effect of dasatinib , an inhibitor of Src and Abl kinases , on paclitaxel sensitivity was measured in ovarian cancer cells and HEY xenografts .

[{'class': 'POS', 'spans': ['dasatinib', 'paclitaxel'], 'is_context_needed': True}]

The maximum tolerated dose ( MTD ) was 20 mg/m2/day I.V. bolus for 5 days of fludarabine plus 60 mg/m2/day I.V. of paclitaxel given as a continuous infusion over 72 hours .

[{'class': 'POS', 'spans': ['fludarabine', 'paclitaxel'], 'is_context_needed': True}]

Further studies are needed to identify predictors of response and toxicity to this approach , as well as the optimal scheduling of ipilimumab with maintenance nivolumab .

[{'class': 'POS', 'spans': ['ipilimumab', 'nivolumab'], 'is_context_needed': True}]

Efficacy of palonosetron plus aprepitant in preventing chemoradiotherapy-induced nausea and emesis in patients receiving daily low-dose cisplatin-based concurrent chemoradiotherapy for uterine cervical cancer : a phase II study .

[{'class': 'POS', 'spans': ['palonosetron', 'aprepitant'], 'is_context_needed': True}]

Pre/peri/postmenopausal women with HR+/HER2- MBC were randomized 2:1 to fulvestrant ( 500 mg ) and either palbociclib ( 125 mg/day ; 3 weeks on/1 week off ; n = 347 ) or placebo ( n = 174 ) . Prespecified exploratory analyses compared the efficacy ( data cutoff : October 23 , 2015 ) , safety , and pharmacokinetics ( data cutoff : December 5 , 2014 ) in Japanese women versus the overall population .

[{'class': 'POS', 'spans': ['fulvestrant', 'palbociclib'], 'is_context_needed': True}]

was lowest in the propofol + dexmedetomidine group ( all , P < 0.05 ) , and the AUC of pulse oximetry was significantly higher in the propofol + dexmedetomidine and propofol + ketamine groups compared to the other 2 groups ( both , P < 0.05 ) .

[{'class': 'POS', 'spans': ['propofol', 'ketamine'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 1, 2, 3], 'is_context_needed': True}]

Patients aged 15 to 60 years , presenting with newly diagnosed acute myeloid leukemia ( AML ) were randomized to receive either high-dose cytarabine , 3 g/m2 12 hourly on days 1 , 3 , 5 , and 7 for 8 doses , daunorubicin 50 mg/m2 days 1 to 3 , etoposide 75 mg/m2 days 1 to 7 , ( HIDAC-3 - 7 ) or standard dose cytarabine 100 mg/m2 continuous intravenous infusion for 7 days with daunorubicin and etoposide at the same dose and schedule as above ( 7 - 3 - 7 ) .

[{'class': 'COMB', 'spans': ['cytarabine', 'daunorubicin', 'etoposide'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [3, 4, 5], 'is_context_needed': True}]

Therefore , if a combination regimen is necessary to control CMV in a patient , foscarnet and ganciclovir should be used first .

[{'class': 'POS', 'spans': ['foscarnet', 'ganciclovir'], 'is_context_needed': False}]

A Phase Ib/II Study of Afatinib in Combination with Nimotuzumab in Non-Small Cell Lung Cancer Patients with Acquired Resistance to Gefitinib or Erlotinib .

[{'class': 'POS', 'spans': ['Afatinib', 'Nimotuzumab'], 'is_context_needed': True}]

RESULTS In first-line treatment , compared with sunitinib , improvement of one-year CPFS for the nivolumab plus ipilimumab group after living for 0.5 and 0.75 years were 14 % ( from 53.0 % to 67.0 % ) and 16 % ( from 57.0 % to 73.0 % ) higher than the one-year PFS of 6.5 % ( from 42.9 % to 49.4 % ) , with similar results for one-year COS following first-line treatment .

[{'class': 'POS', 'spans': ['nivolumab', 'ipilimumab'], 'is_context_needed': True}]

This study analysed 126 patients with relapsed , advanced stage follicular lymphoma who received BEAM ( BCNU [ carmustine ] , cytarabine , etoposide , melphalan)-alemtuzumab allogeneic HSCT ( BEAM-allo ) ( n = 44 ) or BEAM-autologous HSCT ( BEAM-auto ) ( n = 82 ) .

[{'class': 'COMB', 'spans': ['carmustine', 'cytarabine', 'etoposide', 'melphalan)-alemtuzumab'], 'is_context_needed': True}]

Apixaban and rivaroxaban were evaluated in phase III trials for prevention of recurrent ischaemia in ACS patients , most of whom were also receiving dual antiplatelet therapy with aspirin and clopidogrel .

[{'class': 'COMB', 'spans': ['aspirin', 'clopidogrel'], 'is_context_needed': True}]

Furthermore , VPA significantly increased chemosensitivity to fludarabine , flavopiridol , bortezomib , thalidomide and lenalidomide .

[{'class': 'POS', 'spans': ['VPA', 'fludarabine'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 3], 'is_context_needed': False}]

Use of the tumor-infiltrating CD8 to FOXP3 lymphocyte ratio in predicting treatment responses to combination therapy with pertuzumab , trastuzumab , and docetaxel for advanced HER2-positive breast cancer .

[{'class': 'POS', 'spans': ['pertuzumab', 'trastuzumab', 'docetaxel'], 'is_context_needed': True}]

The clinical symptoms were relieved after combination of doxycycline , rifampicin , levofloxacin and amikacin for 6 weeks , only one patient with bone destruction needed orthopedic surgery .

[{'class': 'POS', 'spans': ['doxycycline', 'rifampicin', 'levofloxacin', 'amikacin'], 'is_context_needed': False}]

Four years after surgery , she experienced a recurrence of breast cancer in the thoracic wall , and was treated with exemestane , toremifene , and fulvestrant for 1 year and 5 months .

[{'class': 'COMB', 'spans': ['exemestane', 'toremifene', 'fulvestrant'], 'is_context_needed': True}]

Long-term efficacy of doxazosin plus atenolol in the management of severe and sustained arterial hypertension and reversibility of the cardiac damage induced by chronic cathecolamine excess .

[{'class': 'POS', 'spans': ['doxazosin', 'atenolol'], 'is_context_needed': True}]

To evaluate the use of low-molecular-weight heparin ( LMWH ) in combination with low-dose aspirin ( LDA ) for the treatment of antiphospholipid antibody (APA)-associated recurrent pregnancy loss and to compare the results with the use of unfractionated heparin ( UFH ) plus LDA .

[{'class': 'POS', 'spans': ['low-molecular-weight heparin', 'aspirin'], 'is_context_needed': True}]

Therefore , the pain scores were significantly higher in the neostigmine group than the other two groups ( p = 0.02 ) , but no significant difference was found between the two groups that received dexmedetomidine and a combination of dexmedetomidine + neostigmine .

[{'class': 'POS', 'spans': ['dexmedetomidine', 'neostigmine'], 'is_context_needed': True}]

[ Two cases of complete response to combination chemotherapy of gemcitabine and docetaxel for recurrent ovarian cancer ] .

[{'class': 'POS', 'spans': ['gemcitabine', 'docetaxel'], 'is_context_needed': False}]

Hormonal changes in postmenopausal women with breast cancer treated with trilostane and dexamethasone .

[{'class': 'COMB', 'spans': ['trilostane', 'dexamethasone'], 'is_context_needed': True}]

After surgical insertion of a catheter in the hepatic artery , patients were treated with oxaliplatin 100 mg/m(2 ) HAI combined with FU + leucovorin IV according to the LV5FU2 protocol .

[{'class': 'POS', 'spans': ['oxaliplatin', 'leucovorin'], 'is_context_needed': True}]

Then , doxorubicin with or without flavopiridol was injected .

[{'class': 'POS', 'spans': ['doxorubicin', 'flavopiridol'], 'is_context_needed': True}]

Subjects were treated in two cycles , 3 months apart , in which they received bicalutamide 150 mg daily days 1 - 28 and tremelimumab on day 29 .

[{'class': 'COMB', 'spans': ['bicalutamide', 'tremelimumab'], 'is_context_needed': True}]

This study examines a novel regimen utilizing the combination of epidurally infused ropivacaine - hydromorphone and scheduled ketorolac .

[{'class': 'POS', 'spans': ['ropivacaine', 'hydromorphone', 'ketorolac'], 'is_context_needed': True}]

Patients in the HXP arm also received trastuzumab ( 8 mg/kg intravenous infusion on Day 1 ) , concurrently with capecitabine .

[{'class': 'COMB', 'spans': ['trastuzumab', 'capecitabine'], 'is_context_needed': True}]

Among targeted therapies , lapatinib has activity in systemic treatment of BM particularly when used in combination with capecitabine .

[{'class': 'POS', 'spans': ['lapatinib', 'capecitabine'], 'is_context_needed': False}]

An in vitro assessment of azithromycin in combination with gentamicin demonstrated inhibition of growth and suggests that clinical trials may be warranted to assess the utility of this combination in treating gonorrhea infections .

[{'class': 'POS', 'spans': ['azithromycin', 'gentamicin'], 'is_context_needed': False}]