bala1524/Drug_Combination_Extraction · Datasets at Hugging Face

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Growth inhibition of cloned promastigotes showed that the films have enough releasing capacity and in vivo system , the films containing paromomycin and gentamicin was able to reduce the lesion size and induced complete cure in 80 % of the mice but relapse was seen in 60 % of the cured mice and overall 50 % cure rate was seen during 20 weeks period of the study .	[{'class': 'POS', 'spans': ['paromomycin', 'gentamicin'], 'is_context_needed': False}]
Management and outcome : The patient was initially treated with bortezomib and dexamethasone for the myeloma .	[{'class': 'COMB', 'spans': ['bortezomib', 'dexamethasone'], 'is_context_needed': True}]
Majority of the interventions were to stop the antimicrobial therapy ( 30.3 % ) , and the most common audited antimicrobials was Piperacillin/Tazobactam ( 25.5 % ) , followed by Meropenem ( 11.82 % ) , Amoxicillin/Clavulanate and Vancomycin ( 8.18 % ) respectively .	[]
Clinical Development of the CDK4/6 Inhibitors Ribociclib and Abemaciclib in Breast Cancer .	[]
We retrospectively evaluated 52 metastatic renal cell carcinoma patients who were treated with nivolumab plus ipilimumab between August 2015 and January 2020 .	[{'class': 'POS', 'spans': ['nivolumab', 'ipilimumab'], 'is_context_needed': True}]
Microdialysis-based pharmacokinetic studies demonstrated that administration of the P-gp inhibitor cyclosporin A resulted in increased brain levels of escitalopram without altering plasma escitalopram levels in the rat , thereby showing that P-gp restricts escitalopram transport across the blood-brain barrier ( BBB ) in vivo .	[{'class': 'POS', 'spans': ['cyclosporin', 'escitalopram'], 'is_context_needed': False}]
The combination of mezlocillin and an aminoglycoside produced synergy more often than did carbenicillin plus an aminoglycoside .	[{'class': 'POS', 'spans': ['mezlocillin', 'aminoglycoside'], 'is_context_needed': False}, {'class': 'COMB', 'spans': [1, 3], 'is_context_needed': True}]
Eligible patients ( n = 17 ) were divided into 2 groups receiving a combined chemotherapy of intravenous cisplatinum ( 70 mg/m2 ) and cyclophosphamide ( 700 mg/m2 ) with or without the addition of Lenograstim .	[{'class': 'POS', 'spans': ['cisplatinum', 'cyclophosphamide', 'Lenograstim'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 1], 'is_context_needed': True}]
In particular , caspofungin for invasive candidiasis and voriconazole for invasive aspergillosis seem at least equivalent to amphotericin B. A clear advantage is the advent of lipid formulations of amphotericin B.	[]
Ifosfamide at 12 g/m2 was administered by intravenous continuous infusion over 3 days , and doxorubicin 60 mg/m2 was administered as an intravenous bolus injection on day 1 .	[{'class': 'POS', 'spans': ['Ifosfamide', 'doxorubicin'], 'is_context_needed': True}]
A Randomized , Double-blind , Placebo-controlled Trial of Celecoxib Augmentation of Sertraline in Treatment of Drug-naive Depressed Women : A Pilot Study .	[{'class': 'POS', 'spans': ['Celecoxib', 'Sertraline'], 'is_context_needed': True}]
The aim of this retrospective study was to investigate susceptibility rates of Mycobacterium tuberculosis complex ( MTBC ) isolates against streptomycin , rifampicin , isoniazid , and ethambutol between January 1998 and December 2000 in the Turkish Army .	[]
JAK2 ATP competitive inhibitors ( ruxolitinib , lestaurtinib , SAR302503 , SB1518 and CYT387 ) or drugs that indirectly inhibit the JAK-STAT pathway ( everolimus ) have documented major effects on splenomegaly and its constitutional symptoms .	[]
We therefore tested second-generation inhibitors of the 20S proteasome ( delanzomib , carfilzomib and ixazomib ) with better pharmacologic profiles as well as compounds targeting regulators of ubiquitination ( b-AP15 , MLN4924 ) for their effectiveness and mechanism of action in GIST .	[]
In seven patients with type B insulin resistance , standardized treatment with rituximab , cyclophosphamide , and pulse steroids results in remission of the disease .	[{'class': 'POS', 'spans': ['rituximab', 'cyclophosphamide', 'steroids'], 'is_context_needed': False}]
The purpose of this study was to determine the fertility rates following treatment by means of the BEACOPP regimen ( regular and escalated ) ( bleomycin , etoposide , doxorubicin , cyclophosphamide , vincristine , procarbazine , prednisone ) as compared to the ABVD regimen ( doxorubicin , vinblastine , dacarbazine , bleomycin ) in Hodgkin lymphoma patients under the age of 40 at the time of treatment .	[{'class': 'POS', 'spans': ['bleomycin', 'etoposide', 'doxorubicin', 'cyclophosphamide', 'vincristine', 'procarbazine', 'prednisone'], 'is_context_needed': True}, {'class': 'POS', 'spans': [8, 9, 10, 7], 'is_context_needed': True}]
The positive inotropism of DPDPE was abrogated in animals pretreated with propranolol , CGRP(8 - 37 ) , or combined propranolol+CGRP(8 - 37 ) .	[{'class': 'COMB', 'spans': ['DPDPE', 'propranolol'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 1, 2], 'is_context_needed': True}]
A case of Scedosporium apiospermum infection after BMT , treated initially with amphotericin B ( total dose of 2.5 g ) and then with itraconazole ( for 25 days ) , is reported here .	[{'class': 'NEG', 'spans': ['amphotericin', 'itraconazole'], 'is_context_needed': True}]
Thymidine Phosphorylase/β-tubulin III expressions predict the response in Chinese advanced gastric cancer patients receiving first-line capecitabine plus paclitaxel .	[{'class': 'COMB', 'spans': ['capecitabine', 'paclitaxel'], 'is_context_needed': True}]
An equihypotensive dose of the calcium antagonist nifedipine had no significant effect ; however , EMD 52692 produced the same reduction in infarct size as had nicorandil .	[]
Intravesical epirubicin was generally tolerated as well as intravesical doxorubicin and was associated with a lower incidence of mild chemical cystitis in 1 clinical trial .	[]
Modeling of the pharmacokinetic/pharmacodynamic interaction between irbesartan and hydrochlorothiazide in normotensive subjects .	[{'class': 'COMB', 'spans': ['irbesartan', 'hydrochlorothiazide'], 'is_context_needed': True}]
We tested to what extent preincubation with the ribonucleotide reductase inhibitors fludarabine ( F-ara-A ) and hydroxyurea ( HU ) enhanced ara-CTP levels in two human myeloid ( HL-60 , CMK ) and two lymphoblastic leukemia cell lines ( MOLT-4 , BLIN-1 ) and also in blasts from 28 children with acute leukemia ( AML : 14 , ALL : 14 ) .	[]
In Group IV , the augmentation of Pdi by olprinone was abolished in the fatigued diaphragm with an infusion of nicardipine .	[{'class': 'NEG', 'spans': ['olprinone', 'nicardipine'], 'is_context_needed': False}]
Telmisartan inhibited TPA-induced cell proliferation stronger than candesartan .	[]
A single 1-g dose of oral azithromycin is as effective as a seven-day course of oral doxycycline , 100 mg twice a day , for the treatment of chlamydial infection .	[]
The side-effects of halofantrine and mefloquine were comparable and transient .	[]
Significantly , green tea polyphenols , as well as several flavonoids such as genistein , curcumin and resveratrol , have also been shown to have chemo-sensitizing properties in prostate , breast , hepatic , and lung tumors .	[]
In a 71 years-old patient , a severe therapy-resistant depressive episode without psychotic symptoms was successfully treated by a combination of paroxetine and risperidone .	[{'class': 'POS', 'spans': ['paroxetine', 'risperidone'], 'is_context_needed': False}]
While there is no standard of care for PBL , current recommendations include dose-adjusted EPOCH ( etoposide , vincristine , doxorubicin , cyclophosphamide , and prednisone ) , with or without bortezomib .	[{'class': 'POS', 'spans': ['etoposide', 'vincristine', 'doxorubicin', 'cyclophosphamide', 'prednisone'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 1, 2, 3, 4, 5], 'is_context_needed': False}]
Our report of a patient with severe tardive dyskinesia ( TD ) who has been exposed to both typical antipsychotic and clozapine , olanzapine and quetiapine during a 124-week follow-up period supports the possible beneficial effect of atypical antipsychotics on pre-existing symptoms of TD .	[{'class': 'POS', 'spans': ['clozapine', 'olanzapine', 'quetiapine'], 'is_context_needed': False}]
Paclitaxel plus bevacizumab in patients with chemosensitive relapsed small cell lung cancer : a safety , feasibility , and efficacy study from the Hoosier Oncology Group .	[{'class': 'NEG', 'spans': ['Paclitaxel', 'bevacizumab'], 'is_context_needed': True}]
On day ten of admission , HIT panel was positive , and Dabigatran was changed to Lepirudin .	[]
If in vivo testing confirms the in vitro effectiveness of azithromycin , it may prove to be the drug of choice for the treatment of scrub typhus in children and pregnant women , who should not take doxycycline , and in patients with refractory disease from locations where doxycycline-resistant strains of R. tsutsugamushi have been found .	[]
Significantly , genes regulated by both formoterol and budesonide were overrepresented in the genome ; moreover , budesonide-plus-formoterol induced and repressed 609 and 577 mRNAs , respectively , of which ~1/3 failed the cut-off criterion for either treatment alone .	[{'class': 'POS', 'spans': ['formoterol', 'budesonide'], 'is_context_needed': True}]
This study aimed to investigate the therapeutic responses of lung cancer mice models with adenocarcinoma HCC827 ( gefitinib sensitive ) and HCC827R ( gefitinib resistant ) to the epidermal growth factor receptor-tyrosine kinase inhibitor erlotinib alone and in combination with the anti-angiogenesis agent bevacizumab using dynamic contrast enhanced ( DCE ) and diffusion-weighted MRI .	[{'class': 'POS', 'spans': ['gefitinib', 'erlotinib'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 2, 3], 'is_context_needed': True}]
, olmesartan medoxomil + amlodipine + HCTZ was more effective in reducing BP and achieving BP goals than each of the dual therapies , irrespective of hypertension severity , age , sex , race or diabetes mellitus status .	[{'class': 'POS', 'spans': ['olmesartan medoxomil', 'amlodipine', 'HCTZ'], 'is_context_needed': False}]
Multiple-dose pharmacokinetics of telmisartan and of hydrochlorothiazide following concurrent administration in healthy subjects .	[{'class': 'POS', 'spans': ['telmisartan', 'hydrochlorothiazide'], 'is_context_needed': True}]
The objective of the current study was to determine whether adding the mammalian target of rapamycin inhibitor temsirolimus to sorafenib could improve on these results .	[{'class': 'POS', 'spans': ['temsirolimus', 'sorafenib'], 'is_context_needed': True}]
The authors report the case of a 4-year-old boy with a diagnosis of stage IV neuroblastoma ( NB ) , who had been treated with 6 cycles of cyclophosphamide , doxorubicin , cisplatin , and etoposide for 12 months .	[{'class': 'COMB', 'spans': ['cyclophosphamide', 'doxorubicin', 'cisplatin', 'etoposide'], 'is_context_needed': True}]
Days of utilization , adherence ( proportion of days covered ≥0.8 ) , and discontinuation ( non-use for ≥30 days immediately prior to BP measurement ) of three statins ( atorvastatin , pravastatin , and simvastatin ) over a period of up to 2 years was monitored retrospectively from electronic databases .	[]
Due to dose-limiting toxicity ( DLT ) in both patients ( elevated transaminases and thrombocytopenia ) , an additional three patients were treated on dose level -1 with trabectedin 0.7 mg/m2 plus gemcitabine 700 mg/m2 .	[{'class': 'NEG', 'spans': ['trabectedin', 'gemcitabine'], 'is_context_needed': True}]
Compared with alemtuzumab , bendamustine was considered to be a dominant treatment providing greater benefit ( 6.10 versus 5.37 life years and 4.02 versus 3.45 QALYs ) at lower cost ( $ 78,776 versus $ 121,441 ) .	[]
He accepted surgical resection with followed multi-agent chemotherapy , containing vincristine , doxorubicin , ifosfamide and etoposide .	[{'class': 'POS', 'spans': ['vincristine', 'doxorubicin', 'ifosfamide', 'etoposide'], 'is_context_needed': True}]
The gemcitabine and mitoxantrone regimen was feasible to administer even in heavily pre-treated patients .	[{'class': 'POS', 'spans': ['gemcitabine', 'mitoxantrone'], 'is_context_needed': False}]
The aim of this study was to evaluate four phytocompounds ( cinnamaldehyde , citral , eugenol and geraniol ) for their in vitro inhibitory activity against pre-formed biofilms of Candida albicans alone or in combination with fluconazole and amphotericin B. These compounds were also tested at subinhibitory concentrations for their ability to inhibit biofilm formation .	[{'class': 'POS', 'spans': ['cinnamaldehyde', 'fluconazole'], 'is_context_needed': True}]
Neoadjuvant trastuzumab , pertuzumab , and chemotherapy versus trastuzumab emtansine plus pertuzumab in patients with HER2-positive breast cancer ( KRISTINE ): a randomised , open-label , multicentre , phase 3 trial .	[{'class': 'POS', 'spans': ['trastuzumab', 'pertuzumab', 'trastuzumab emtansine', 'pertuzumab'], 'is_context_needed': True}]
≥ 3 adverse events ( AE ) than cetuximab and conatumumab , neutropenia than conatumumab , and fatigue than cetuximab .	[]
Ultimately , the patient was successfully treated with combination therapy of Liposomal amphotericin B and Miltefosine without any relapse .	[{'class': 'POS', 'spans': ['amphotericin', 'Miltefosine'], 'is_context_needed': False}]
However , verapamil significantly increased the sensitivity to etoposide , doxorubicin and vincristine in cells highly expressing MRP gene .	[{'class': 'POS', 'spans': ['verapamil', 'etoposide'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 3], 'is_context_needed': False}]
Based on available phase III randomized trials , anti-VEGF agents such as sunitinib , sorafenib , bevacizumab-based therapy , and mTOR-targeted agents such as temsirolimus and everolimus have been used in the treatment armamentarium for this disease .	[]
Synergy was observed in vitro when HCT-116 cells were treated over a broad range of doses of trametinib and palbociclib .	[{'class': 'POS', 'spans': ['trametinib', 'palbociclib'], 'is_context_needed': False}]
Simultaneous automated determination of free and total sulfisoxazole and sulfamethoxazole in plasma and urine .	[]
Background Epidemiological evidence is insufficient to draw conclusions on the impact of low-dose aspirin use on breast cancer risk , and the potential impact of other antiplatelet drugs such as clopidogrel needs to be explored .	[]
Using a FOLFOXIRI ( 5-fluorouracil [ 5-FU ] , irinotecan , and oxaliplatin ) combination regimen , patients with metastatic colorectal cancer now have the possibility of longer survival , but disappointingly , with increased toxicities .	[{'class': 'POS', 'spans': ['5-FU', 'irinotecan', 'oxaliplatin'], 'is_context_needed': False}]
Combinations of antibodies with targeted drugs like ibrutinib , idelalisib , or lenalidomide are expected to replace chemotherapy-based combinations for treating CLL in the near future .	[{'class': 'POS', 'spans': ['antibodies', 'ibrutinib'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 3], 'is_context_needed': False}]
The responses to quinine and mefloquine or halofantrine showed no correlation with each other .	[{'class': 'COMB', 'spans': ['quinine', 'mefloquine'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}]
In a phase II study , we treated 26 consecutive patients with refractory advanced sarcoma with ifosfamide and etoposide combination chemotherapy .	[{'class': 'POS', 'spans': ['ifosfamide', 'etoposide'], 'is_context_needed': True}]
A case of delivery of healthy infant in breast cancer patient incidentally treated with goserelin acetate and tamoxifen during pregnancy .	[{'class': 'POS', 'spans': ['goserelin acetate', 'tamoxifen'], 'is_context_needed': False}]
Treatment-naive patients with nonmetastatic N2 or N3 SCCHN were randomly assigned to CRT alone ( CRT arm ; docetaxel , fluorouracil , and hydroxyurea plus radiotherapy 0.15 Gy twice per day every other week ) versus two 21-day cycles of IC ( docetaxel 75 mg/m(2 ) on day 1 , cisplatin 75 mg/m(2 ) on day 1 , and fluorouracil 750 mg/m(2 ) on days 1 to 5 ) followed by the same CRT regimen ( IC + CRT arm ) .	[{'class': 'NEG', 'spans': ['docetaxel', 'cisplatin', 'fluorouracil'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 1, 2], 'is_context_needed': True}]
A new method for the quantitative analysis by liquid chromatography-tandem mass spectrometry ( LC-MS/MS ) of five tyrosine kinase inhibitors ( afatinib , crizotinib , osimertinib , erlotinib and nintedanib ) used in the treatment of non-small cell lung cancer ( NSCLC ) was developed and validated in human plasma .	[]
The objective of this study was to compare the effect of sildenafil alone and sildenafil with bosentan on severity of tricuspid regurgitation and duration of hospitalization in new-borns with persistent pulmonary hypertension .	[{'class': 'POS', 'spans': ['sildenafil', 'bosentan'], 'is_context_needed': True}]
In Crohn 's disease in remission after 6 months of azathioprine in combination with infliximab , 63.8 % of practitioners discontinued azathioprine .	[{'class': 'NEG', 'spans': ['azathioprine', 'infliximab'], 'is_context_needed': False}]
Anti-androgen receptor ASC-J9 versus anti-androgens MDV3100 ( Enzalutamide ) or Casodex ( Bicalutamide ) leads to opposite effects on prostate cancer metastasis via differential modulation of macrophage infiltration and STAT3-CCL2 signaling .	[]
Long-term outcome for men with androgen independent prostate cancer treated with ketoconazole and hydrocortisone .	[{'class': 'POS', 'spans': ['ketoconazole', 'hydrocortisone'], 'is_context_needed': False}]
Randomized trial of betahistine mesilate tablets as augmentation for oxcarbazepine and carbamazepine in treating vestibular paroxysmia .	[{'class': 'POS', 'spans': ['betahistine', 'oxcarbazepine'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': True}]
Sorafenib in combination with gemcitabine in recurrent epithelial ovarian cancer : a study of the Princess Margaret Hospital Phase II Consortium .	[{'class': 'POS', 'spans': ['Sorafenib', 'gemcitabine'], 'is_context_needed': True}]
Pharmacological inhibition of p70S6 K using the PI3K/mTOR inhibitor NVP-BEZ235 , the specific mTOR inhibitor Rapamycin and the specific p70S6 K inhibitor PF-4708671 potentiated Selumetinib effects in resistant cells .	[{'class': 'POS', 'spans': ['Selumetinib', 'NVP-BEZ235'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 1], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 3], 'is_context_needed': False}]
Vinorelbine , ifosfamide and cisplatin as first-line treatment in patients with inoperable non-small cell lung cancer .	[{'class': 'POS', 'spans': ['Vinorelbine', 'ifosfamide', 'cisplatin'], 'is_context_needed': True}]
Two large Phase III trials conducted in the Americas and across Europe , Australia , and Asia showed lower cumulative pregnancy rates in the NOMAC/E2 groups compared to the drospirenone ( DRSP ) 3 mg in combination with ethinyl estradiol ( EE ) 30 µg ( DRSP/EE ) groups but this difference was not statistically significant .	[{'class': 'POS', 'spans': ['drospirenone', 'ethinyl estradiol'], 'is_context_needed': False}]
Using 146 surgically resected specimens of NSCLC , p53 status was immunohistochemically evaluated , and in vitro chemosensitivity to 5-fluorouracil ( 5-Fu ) , cisplatin ( CDDP ) , mitomycin C ( MMC ) , etoposide ( VP-16 ) , doxorubicin hydrochloride ( ADM ) , and vindesine sulfate ( VDS ) was examined by a collagen gel-droplet embedded culture drug sensitivity test ( CD-DST , Int J Oncol , 1997;11:449 ) .	[]
The objective was to compare the pharmacodynamic ( PD ) and pharmacokinetic ( PK ) effects of ticagrelor with clopidogrel among subjects of Hispanic ethnicity , as the PD and PK effects of antiplatelet agents among Hispanics are not specifically known .	[{'class': 'COMB', 'spans': ['ticagrelor', 'clopidogrel'], 'is_context_needed': True}]
For example , the renal excretion of methotrexate by glomerular filtration and tubular secretion is affected by a number of weak organic acids , such as probenecid , salicylates and penicillin , which compete for tubular secretion , resulting in delayed clearance of methotrexate .	[{'class': 'POS', 'spans': ['methotrexate', 'probenecid'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 3], 'is_context_needed': False}]
To investigate the cardiac safety of adjuvant Non-Pegylated Liposomal Doxorubicin ( NPL-DOX ) combined to Cyclophosphamide ( CTX ) and followed by weekly Paclitaxel , in older patients ( ≥65 years ) with diagnosis of high risk breast cancer .	[{'class': 'POS', 'spans': ['Doxorubicin', 'Cyclophosphamide', 'Paclitaxel'], 'is_context_needed': True}]
The high incidence of imported malaria ( 0.70 % ) and the low costs of providing chemoprophylaxis resulted in a cost-benefit ratio of 0.19 for chloroquine and proguanil and 0.57 for a regimen containing mefloquine .	[{'class': 'POS', 'spans': ['chloroquine', 'proguanil'], 'is_context_needed': False}]
Clinical trials suggest reduced benefit from the combination of cetuximab with oxaliplatin .	[{'class': 'NEG', 'spans': ['cetuximab', 'oxaliplatin'], 'is_context_needed': False}]
L-carnitine was administered 1 h before doxorubicin injection and daily thereafter for 15 days .	[{'class': 'POS', 'spans': ['L-carnitine', 'doxorubicin'], 'is_context_needed': True}]
New chemotherapeutic agents such as gemcitabine appear to have the potential to produce better results than those achieved over the last 35 years with fluorouracil .	[]
Comparative effectiveness of rituximab , abatacept , and tocilizumab in adults with rheumatoid arthritis and inadequate response to TNF inhibitors : prospective cohort study .	[]
Recoveries of both amino acids were increased bilaterally by local perfusion with veratridine ( 100 microM , given under halothane anaesthesia ) , pretreatment with reserpine ( 4 mg/kg , i.p . , 24 h beforehand ) , unilateral pretreatment of the medial forebrain bundle with 6-OHDA ( 8 microg/4 microl ) , and by the systemic ( 1 mg/kg , i.p . ) or bilateral intrastriatal ( 7 microg/0.5 microl under halothane anaesthesia ) administration of the dopamine D2 receptor antagonist haloperidol , but not raclopride ( 2 mg/kg , i.p . ) .	[{'class': 'POS', 'spans': ['reserpine', 'veratridine'], 'is_context_needed': False}, {'class': 'POS', 'spans': [3, 5], 'is_context_needed': False}, {'class': 'NEG', 'spans': [5, 6], 'is_context_needed': False}]
Combined initial cyclophosphamide with repeated methylprednisolone pulse therapy for severe paraquat poisoning from dermal exposure .	[{'class': 'POS', 'spans': ['cyclophosphamide', 'methylprednisolone'], 'is_context_needed': True}]
These adverse effects were all more frequent than with docetaxel or pemetrexed .	[]
Hyper-CVAD , given in odd-number courses ( Courses 1 , 3 , 5 , and 7 ) , was alternated with methotrexate and cytarabine ( MTX/Ara-C ) , given in even-number courses ( Courses 2 , 4 , 6 , and 8) .	[{'class': 'POS', 'spans': ['methotrexate', 'cytarabine'], 'is_context_needed': True}]
Despite systemic chemotherapy combining pemetrexed , bevacizumab and Cisplatinum , the disease relapsed eight months later with multiple metastatic lung nodules leading to a treatment shift .	[{'class': 'NEG', 'spans': ['pemetrexed', 'bevacizumab', 'Cisplatinum'], 'is_context_needed': False}]
Trastuzumab , which is still the first-line therapy in breast cancer , increases the pCR rate more than lapatinib .	[]
Recently , several novel agents are under clinical development for advanced colorectal cancer , including irinotecan , oxaliplatin , oral fluoropyrimidines , raltitrexed , monoclonal antibody 17 - 1A and tumour vaccines .	[]
Pretreatment with NaHCO3 , NH4Cl , SKF 525A , piperonyl butoxide , progesterone , cysteamine , phenobarbital or metyrapone prior to the administration of [methyl-14C]nicotine was studied .	[{'class': 'POS', 'spans': ['[methyl-14C]nicotine', 'metyrapone'], 'is_context_needed': True}, {'class': 'POS', 'spans': [8, 4], 'is_context_needed': True}]
Capecitabine is an oral pro-drug of fluorouracil .	[]
However , the current artemisinin FDC products , such as β-artemether and lumefantrine , are inherently unstable and require controlled distribution and storage conditions , which are not always available in resource-limited settings .	[]
Because the mass invaded the pancreas and superior mesenteric vein as well as duodenum and the disease was disseminated to liver and peritoneum , she received palliative chemotherapy using vincristine , doxorubicin , cyclophosphamide , ifosfamide , and etoposide .	[{'class': 'POS', 'spans': ['vincristine', 'doxorubicin', 'cyclophosphamide', 'ifosfamide', 'etoposide'], 'is_context_needed': False}]
In HCV genotype 1 infection and F3 or F4 liver fibrosis , treatment with boceprevir or telaprevir in addition to pegylated interferon and ribavirin is recommended .	[{'class': 'POS', 'spans': ['boceprevir', 'pegylated interferon', 'ribavirin'], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 2, 3], 'is_context_needed': False}]
Membrane-modifying agents such as reserpine , calcium antagonists ( nicardipine , verapamil ) and calmodulin inhibitor ( trifluoperazine ) were found to enhance the cytotoxicity of ACNU in vitro and in vivo in ACNU-resistant C 6 ( C 6/ACNU ) glioma .	[]
To investigate the efficacy of temozolomide in relation to response rate , toxicity , time to progression . and median survival time , a phase II study was conducted in patients with recurrent high-grade glioma following surgery plus radiotherapy and first-line chemotherapy based on nitrosourea , procarbazine and vincristine .	[]
Ketoconazole inhibited the entire pathway , while exposure to genistein resulted in increased hormone levels upstream of 3-β-hydroxysteroid dehydrogenase ( 3β-HSD ) and decreases downstream .	[]
Melphalan , cisplatin , carboplatin , doxorubicin , and etoposide cytotoxicities were determined by DIMSCAN assay .	[]
As a treatment at the time of progression after pemetrexed-based chemotherapy , erlotinib conferred a survival benefit when compared to docetaxel ( p=0.024 ; hazard ratio , 0.377 ) .	[]
The combination of ifosfamide with oral etoposide appears to have significant but manageable toxicity and encouraging efficacy in platinum resistant ovarian cancer .	[{'class': 'POS', 'spans': ['ifosfamide', 'etoposide'], 'is_context_needed': False}]
After switching from ranibizumab treatment to aflibercept , ORTs remained present in 75 % of eyes , and significant reductions in CMT , PED , and SRF , and presence of intraretinal cysts were observed .	[]
Vinorelbine , gemcitabine , docetaxel , paclitaxel , and irinotecan are all new chemotherapeutic agents which have shown promising activity in this disease .	[]
This Phase I , randomized , open-label study evaluated the gastric pH-altering effects of omeprazole , a proton pump inhibitor , and the CYP3A enzyme/P-glycoprotein (Pgp)-inhibitory effects of ritonavir , an HIV protease inhibitor , on the pharmacokinetics and safety of the hepatitis C virus ( HCV ) non-structural protein 5A ( NS5A ) inhibitor GSK2336805 in healthy male and female subjects .	[{'class': 'POS', 'spans': ['omeprazole', 'ritonavir', 'GSK2336805'], 'is_context_needed': True}]

Growth inhibition of cloned promastigotes showed that the films have enough releasing capacity and in vivo system , the films containing paromomycin and gentamicin was able to reduce the lesion size and induced complete cure in 80 % of the mice but relapse was seen in 60 % of the cured mice and overall 50 % cure rate was seen during 20 weeks period of the study .

[{'class': 'POS', 'spans': ['paromomycin', 'gentamicin'], 'is_context_needed': False}]

Management and outcome : The patient was initially treated with bortezomib and dexamethasone for the myeloma .

[{'class': 'COMB', 'spans': ['bortezomib', 'dexamethasone'], 'is_context_needed': True}]

Majority of the interventions were to stop the antimicrobial therapy ( 30.3 % ) , and the most common audited antimicrobials was Piperacillin/Tazobactam ( 25.5 % ) , followed by Meropenem ( 11.82 % ) , Amoxicillin/Clavulanate and Vancomycin ( 8.18 % ) respectively .

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Clinical Development of the CDK4/6 Inhibitors Ribociclib and Abemaciclib in Breast Cancer .

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We retrospectively evaluated 52 metastatic renal cell carcinoma patients who were treated with nivolumab plus ipilimumab between August 2015 and January 2020 .

[{'class': 'POS', 'spans': ['nivolumab', 'ipilimumab'], 'is_context_needed': True}]

Microdialysis-based pharmacokinetic studies demonstrated that administration of the P-gp inhibitor cyclosporin A resulted in increased brain levels of escitalopram without altering plasma escitalopram levels in the rat , thereby showing that P-gp restricts escitalopram transport across the blood-brain barrier ( BBB ) in vivo .

[{'class': 'POS', 'spans': ['cyclosporin', 'escitalopram'], 'is_context_needed': False}]

The combination of mezlocillin and an aminoglycoside produced synergy more often than did carbenicillin plus an aminoglycoside .

[{'class': 'POS', 'spans': ['mezlocillin', 'aminoglycoside'], 'is_context_needed': False}, {'class': 'COMB', 'spans': [1, 3], 'is_context_needed': True}]

Eligible patients ( n = 17 ) were divided into 2 groups receiving a combined chemotherapy of intravenous cisplatinum ( 70 mg/m2 ) and cyclophosphamide ( 700 mg/m2 ) with or without the addition of Lenograstim .

[{'class': 'POS', 'spans': ['cisplatinum', 'cyclophosphamide', 'Lenograstim'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 1], 'is_context_needed': True}]

In particular , caspofungin for invasive candidiasis and voriconazole for invasive aspergillosis seem at least equivalent to amphotericin B. A clear advantage is the advent of lipid formulations of amphotericin B.

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Ifosfamide at 12 g/m2 was administered by intravenous continuous infusion over 3 days , and doxorubicin 60 mg/m2 was administered as an intravenous bolus injection on day 1 .

[{'class': 'POS', 'spans': ['Ifosfamide', 'doxorubicin'], 'is_context_needed': True}]

A Randomized , Double-blind , Placebo-controlled Trial of Celecoxib Augmentation of Sertraline in Treatment of Drug-naive Depressed Women : A Pilot Study .

[{'class': 'POS', 'spans': ['Celecoxib', 'Sertraline'], 'is_context_needed': True}]

The aim of this retrospective study was to investigate susceptibility rates of Mycobacterium tuberculosis complex ( MTBC ) isolates against streptomycin , rifampicin , isoniazid , and ethambutol between January 1998 and December 2000 in the Turkish Army .

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JAK2 ATP competitive inhibitors ( ruxolitinib , lestaurtinib , SAR302503 , SB1518 and CYT387 ) or drugs that indirectly inhibit the JAK-STAT pathway ( everolimus ) have documented major effects on splenomegaly and its constitutional symptoms .

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We therefore tested second-generation inhibitors of the 20S proteasome ( delanzomib , carfilzomib and ixazomib ) with better pharmacologic profiles as well as compounds targeting regulators of ubiquitination ( b-AP15 , MLN4924 ) for their effectiveness and mechanism of action in GIST .

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In seven patients with type B insulin resistance , standardized treatment with rituximab , cyclophosphamide , and pulse steroids results in remission of the disease .

[{'class': 'POS', 'spans': ['rituximab', 'cyclophosphamide', 'steroids'], 'is_context_needed': False}]

The purpose of this study was to determine the fertility rates following treatment by means of the BEACOPP regimen ( regular and escalated ) ( bleomycin , etoposide , doxorubicin , cyclophosphamide , vincristine , procarbazine , prednisone ) as compared to the ABVD regimen ( doxorubicin , vinblastine , dacarbazine , bleomycin ) in Hodgkin lymphoma patients under the age of 40 at the time of treatment .

[{'class': 'POS', 'spans': ['bleomycin', 'etoposide', 'doxorubicin', 'cyclophosphamide', 'vincristine', 'procarbazine', 'prednisone'], 'is_context_needed': True}, {'class': 'POS', 'spans': [8, 9, 10, 7], 'is_context_needed': True}]

The positive inotropism of DPDPE was abrogated in animals pretreated with propranolol , CGRP(8 - 37 ) , or combined propranolol+CGRP(8 - 37 ) .

[{'class': 'COMB', 'spans': ['DPDPE', 'propranolol'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 1, 2], 'is_context_needed': True}]

A case of Scedosporium apiospermum infection after BMT , treated initially with amphotericin B ( total dose of 2.5 g ) and then with itraconazole ( for 25 days ) , is reported here .

[{'class': 'NEG', 'spans': ['amphotericin', 'itraconazole'], 'is_context_needed': True}]

Thymidine Phosphorylase/β-tubulin III expressions predict the response in Chinese advanced gastric cancer patients receiving first-line capecitabine plus paclitaxel .

[{'class': 'COMB', 'spans': ['capecitabine', 'paclitaxel'], 'is_context_needed': True}]

An equihypotensive dose of the calcium antagonist nifedipine had no significant effect ; however , EMD 52692 produced the same reduction in infarct size as had nicorandil .

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Intravesical epirubicin was generally tolerated as well as intravesical doxorubicin and was associated with a lower incidence of mild chemical cystitis in 1 clinical trial .

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Modeling of the pharmacokinetic/pharmacodynamic interaction between irbesartan and hydrochlorothiazide in normotensive subjects .

[{'class': 'COMB', 'spans': ['irbesartan', 'hydrochlorothiazide'], 'is_context_needed': True}]

We tested to what extent preincubation with the ribonucleotide reductase inhibitors fludarabine ( F-ara-A ) and hydroxyurea ( HU ) enhanced ara-CTP levels in two human myeloid ( HL-60 , CMK ) and two lymphoblastic leukemia cell lines ( MOLT-4 , BLIN-1 ) and also in blasts from 28 children with acute leukemia ( AML : 14 , ALL : 14 ) .

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In Group IV , the augmentation of Pdi by olprinone was abolished in the fatigued diaphragm with an infusion of nicardipine .

[{'class': 'NEG', 'spans': ['olprinone', 'nicardipine'], 'is_context_needed': False}]

Telmisartan inhibited TPA-induced cell proliferation stronger than candesartan .

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A single 1-g dose of oral azithromycin is as effective as a seven-day course of oral doxycycline , 100 mg twice a day , for the treatment of chlamydial infection .

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The side-effects of halofantrine and mefloquine were comparable and transient .

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Significantly , green tea polyphenols , as well as several flavonoids such as genistein , curcumin and resveratrol , have also been shown to have chemo-sensitizing properties in prostate , breast , hepatic , and lung tumors .

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In a 71 years-old patient , a severe therapy-resistant depressive episode without psychotic symptoms was successfully treated by a combination of paroxetine and risperidone .

[{'class': 'POS', 'spans': ['paroxetine', 'risperidone'], 'is_context_needed': False}]

While there is no standard of care for PBL , current recommendations include dose-adjusted EPOCH ( etoposide , vincristine , doxorubicin , cyclophosphamide , and prednisone ) , with or without bortezomib .

[{'class': 'POS', 'spans': ['etoposide', 'vincristine', 'doxorubicin', 'cyclophosphamide', 'prednisone'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 1, 2, 3, 4, 5], 'is_context_needed': False}]

Our report of a patient with severe tardive dyskinesia ( TD ) who has been exposed to both typical antipsychotic and clozapine , olanzapine and quetiapine during a 124-week follow-up period supports the possible beneficial effect of atypical antipsychotics on pre-existing symptoms of TD .

[{'class': 'POS', 'spans': ['clozapine', 'olanzapine', 'quetiapine'], 'is_context_needed': False}]

Paclitaxel plus bevacizumab in patients with chemosensitive relapsed small cell lung cancer : a safety , feasibility , and efficacy study from the Hoosier Oncology Group .

[{'class': 'NEG', 'spans': ['Paclitaxel', 'bevacizumab'], 'is_context_needed': True}]

On day ten of admission , HIT panel was positive , and Dabigatran was changed to Lepirudin .

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If in vivo testing confirms the in vitro effectiveness of azithromycin , it may prove to be the drug of choice for the treatment of scrub typhus in children and pregnant women , who should not take doxycycline , and in patients with refractory disease from locations where doxycycline-resistant strains of R. tsutsugamushi have been found .

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Significantly , genes regulated by both formoterol and budesonide were overrepresented in the genome ; moreover , budesonide-plus-formoterol induced and repressed 609 and 577 mRNAs , respectively , of which ~1/3 failed the cut-off criterion for either treatment alone .

[{'class': 'POS', 'spans': ['formoterol', 'budesonide'], 'is_context_needed': True}]

This study aimed to investigate the therapeutic responses of lung cancer mice models with adenocarcinoma HCC827 ( gefitinib sensitive ) and HCC827R ( gefitinib resistant ) to the epidermal growth factor receptor-tyrosine kinase inhibitor erlotinib alone and in combination with the anti-angiogenesis agent bevacizumab using dynamic contrast enhanced ( DCE ) and diffusion-weighted MRI .

[{'class': 'POS', 'spans': ['gefitinib', 'erlotinib'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 2, 3], 'is_context_needed': True}]

, olmesartan medoxomil + amlodipine + HCTZ was more effective in reducing BP and achieving BP goals than each of the dual therapies , irrespective of hypertension severity , age , sex , race or diabetes mellitus status .

[{'class': 'POS', 'spans': ['olmesartan medoxomil', 'amlodipine', 'HCTZ'], 'is_context_needed': False}]

Multiple-dose pharmacokinetics of telmisartan and of hydrochlorothiazide following concurrent administration in healthy subjects .

[{'class': 'POS', 'spans': ['telmisartan', 'hydrochlorothiazide'], 'is_context_needed': True}]

The objective of the current study was to determine whether adding the mammalian target of rapamycin inhibitor temsirolimus to sorafenib could improve on these results .

[{'class': 'POS', 'spans': ['temsirolimus', 'sorafenib'], 'is_context_needed': True}]

The authors report the case of a 4-year-old boy with a diagnosis of stage IV neuroblastoma ( NB ) , who had been treated with 6 cycles of cyclophosphamide , doxorubicin , cisplatin , and etoposide for 12 months .

[{'class': 'COMB', 'spans': ['cyclophosphamide', 'doxorubicin', 'cisplatin', 'etoposide'], 'is_context_needed': True}]

Days of utilization , adherence ( proportion of days covered ≥0.8 ) , and discontinuation ( non-use for ≥30 days immediately prior to BP measurement ) of three statins ( atorvastatin , pravastatin , and simvastatin ) over a period of up to 2 years was monitored retrospectively from electronic databases .

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Due to dose-limiting toxicity ( DLT ) in both patients ( elevated transaminases and thrombocytopenia ) , an additional three patients were treated on dose level -1 with trabectedin 0.7 mg/m2 plus gemcitabine 700 mg/m2 .

[{'class': 'NEG', 'spans': ['trabectedin', 'gemcitabine'], 'is_context_needed': True}]

Compared with alemtuzumab , bendamustine was considered to be a dominant treatment providing greater benefit ( 6.10 versus 5.37 life years and 4.02 versus 3.45 QALYs ) at lower cost ( $ 78,776 versus $ 121,441 ) .

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He accepted surgical resection with followed multi-agent chemotherapy , containing vincristine , doxorubicin , ifosfamide and etoposide .

[{'class': 'POS', 'spans': ['vincristine', 'doxorubicin', 'ifosfamide', 'etoposide'], 'is_context_needed': True}]

The gemcitabine and mitoxantrone regimen was feasible to administer even in heavily pre-treated patients .

[{'class': 'POS', 'spans': ['gemcitabine', 'mitoxantrone'], 'is_context_needed': False}]

The aim of this study was to evaluate four phytocompounds ( cinnamaldehyde , citral , eugenol and geraniol ) for their in vitro inhibitory activity against pre-formed biofilms of Candida albicans alone or in combination with fluconazole and amphotericin B. These compounds were also tested at subinhibitory concentrations for their ability to inhibit biofilm formation .

[{'class': 'POS', 'spans': ['cinnamaldehyde', 'fluconazole'], 'is_context_needed': True}]

Neoadjuvant trastuzumab , pertuzumab , and chemotherapy versus trastuzumab emtansine plus pertuzumab in patients with HER2-positive breast cancer ( KRISTINE ): a randomised , open-label , multicentre , phase 3 trial .

[{'class': 'POS', 'spans': ['trastuzumab', 'pertuzumab', 'trastuzumab emtansine', 'pertuzumab'], 'is_context_needed': True}]

≥ 3 adverse events ( AE ) than cetuximab and conatumumab , neutropenia than conatumumab , and fatigue than cetuximab .

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Ultimately , the patient was successfully treated with combination therapy of Liposomal amphotericin B and Miltefosine without any relapse .

[{'class': 'POS', 'spans': ['amphotericin', 'Miltefosine'], 'is_context_needed': False}]

However , verapamil significantly increased the sensitivity to etoposide , doxorubicin and vincristine in cells highly expressing MRP gene .

[{'class': 'POS', 'spans': ['verapamil', 'etoposide'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 3], 'is_context_needed': False}]

Based on available phase III randomized trials , anti-VEGF agents such as sunitinib , sorafenib , bevacizumab-based therapy , and mTOR-targeted agents such as temsirolimus and everolimus have been used in the treatment armamentarium for this disease .

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Synergy was observed in vitro when HCT-116 cells were treated over a broad range of doses of trametinib and palbociclib .

[{'class': 'POS', 'spans': ['trametinib', 'palbociclib'], 'is_context_needed': False}]

Simultaneous automated determination of free and total sulfisoxazole and sulfamethoxazole in plasma and urine .

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Background Epidemiological evidence is insufficient to draw conclusions on the impact of low-dose aspirin use on breast cancer risk , and the potential impact of other antiplatelet drugs such as clopidogrel needs to be explored .

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Using a FOLFOXIRI ( 5-fluorouracil [ 5-FU ] , irinotecan , and oxaliplatin ) combination regimen , patients with metastatic colorectal cancer now have the possibility of longer survival , but disappointingly , with increased toxicities .

[{'class': 'POS', 'spans': ['5-FU', 'irinotecan', 'oxaliplatin'], 'is_context_needed': False}]

Combinations of antibodies with targeted drugs like ibrutinib , idelalisib , or lenalidomide are expected to replace chemotherapy-based combinations for treating CLL in the near future .

[{'class': 'POS', 'spans': ['antibodies', 'ibrutinib'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 3], 'is_context_needed': False}]

The responses to quinine and mefloquine or halofantrine showed no correlation with each other .

[{'class': 'COMB', 'spans': ['quinine', 'mefloquine'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}]

In a phase II study , we treated 26 consecutive patients with refractory advanced sarcoma with ifosfamide and etoposide combination chemotherapy .

[{'class': 'POS', 'spans': ['ifosfamide', 'etoposide'], 'is_context_needed': True}]

A case of delivery of healthy infant in breast cancer patient incidentally treated with goserelin acetate and tamoxifen during pregnancy .

[{'class': 'POS', 'spans': ['goserelin acetate', 'tamoxifen'], 'is_context_needed': False}]

Treatment-naive patients with nonmetastatic N2 or N3 SCCHN were randomly assigned to CRT alone ( CRT arm ; docetaxel , fluorouracil , and hydroxyurea plus radiotherapy 0.15 Gy twice per day every other week ) versus two 21-day cycles of IC ( docetaxel 75 mg/m(2 ) on day 1 , cisplatin 75 mg/m(2 ) on day 1 , and fluorouracil 750 mg/m(2 ) on days 1 to 5 ) followed by the same CRT regimen ( IC + CRT arm ) .

[{'class': 'NEG', 'spans': ['docetaxel', 'cisplatin', 'fluorouracil'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 1, 2], 'is_context_needed': True}]

A new method for the quantitative analysis by liquid chromatography-tandem mass spectrometry ( LC-MS/MS ) of five tyrosine kinase inhibitors ( afatinib , crizotinib , osimertinib , erlotinib and nintedanib ) used in the treatment of non-small cell lung cancer ( NSCLC ) was developed and validated in human plasma .

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The objective of this study was to compare the effect of sildenafil alone and sildenafil with bosentan on severity of tricuspid regurgitation and duration of hospitalization in new-borns with persistent pulmonary hypertension .

[{'class': 'POS', 'spans': ['sildenafil', 'bosentan'], 'is_context_needed': True}]

In Crohn 's disease in remission after 6 months of azathioprine in combination with infliximab , 63.8 % of practitioners discontinued azathioprine .

[{'class': 'NEG', 'spans': ['azathioprine', 'infliximab'], 'is_context_needed': False}]

Anti-androgen receptor ASC-J9 versus anti-androgens MDV3100 ( Enzalutamide ) or Casodex ( Bicalutamide ) leads to opposite effects on prostate cancer metastasis via differential modulation of macrophage infiltration and STAT3-CCL2 signaling .

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Long-term outcome for men with androgen independent prostate cancer treated with ketoconazole and hydrocortisone .

[{'class': 'POS', 'spans': ['ketoconazole', 'hydrocortisone'], 'is_context_needed': False}]

Randomized trial of betahistine mesilate tablets as augmentation for oxcarbazepine and carbamazepine in treating vestibular paroxysmia .

[{'class': 'POS', 'spans': ['betahistine', 'oxcarbazepine'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': True}]

Sorafenib in combination with gemcitabine in recurrent epithelial ovarian cancer : a study of the Princess Margaret Hospital Phase II Consortium .

[{'class': 'POS', 'spans': ['Sorafenib', 'gemcitabine'], 'is_context_needed': True}]

Pharmacological inhibition of p70S6 K using the PI3K/mTOR inhibitor NVP-BEZ235 , the specific mTOR inhibitor Rapamycin and the specific p70S6 K inhibitor PF-4708671 potentiated Selumetinib effects in resistant cells .

[{'class': 'POS', 'spans': ['Selumetinib', 'NVP-BEZ235'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 1], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 3], 'is_context_needed': False}]

Vinorelbine , ifosfamide and cisplatin as first-line treatment in patients with inoperable non-small cell lung cancer .

[{'class': 'POS', 'spans': ['Vinorelbine', 'ifosfamide', 'cisplatin'], 'is_context_needed': True}]

Two large Phase III trials conducted in the Americas and across Europe , Australia , and Asia showed lower cumulative pregnancy rates in the NOMAC/E2 groups compared to the drospirenone ( DRSP ) 3 mg in combination with ethinyl estradiol ( EE ) 30 µg ( DRSP/EE ) groups but this difference was not statistically significant .

[{'class': 'POS', 'spans': ['drospirenone', 'ethinyl estradiol'], 'is_context_needed': False}]

Using 146 surgically resected specimens of NSCLC , p53 status was immunohistochemically evaluated , and in vitro chemosensitivity to 5-fluorouracil ( 5-Fu ) , cisplatin ( CDDP ) , mitomycin C ( MMC ) , etoposide ( VP-16 ) , doxorubicin hydrochloride ( ADM ) , and vindesine sulfate ( VDS ) was examined by a collagen gel-droplet embedded culture drug sensitivity test ( CD-DST , Int J Oncol , 1997;11:449 ) .

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The objective was to compare the pharmacodynamic ( PD ) and pharmacokinetic ( PK ) effects of ticagrelor with clopidogrel among subjects of Hispanic ethnicity , as the PD and PK effects of antiplatelet agents among Hispanics are not specifically known .

[{'class': 'COMB', 'spans': ['ticagrelor', 'clopidogrel'], 'is_context_needed': True}]

For example , the renal excretion of methotrexate by glomerular filtration and tubular secretion is affected by a number of weak organic acids , such as probenecid , salicylates and penicillin , which compete for tubular secretion , resulting in delayed clearance of methotrexate .

[{'class': 'POS', 'spans': ['methotrexate', 'probenecid'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 3], 'is_context_needed': False}]

To investigate the cardiac safety of adjuvant Non-Pegylated Liposomal Doxorubicin ( NPL-DOX ) combined to Cyclophosphamide ( CTX ) and followed by weekly Paclitaxel , in older patients ( ≥65 years ) with diagnosis of high risk breast cancer .

[{'class': 'POS', 'spans': ['Doxorubicin', 'Cyclophosphamide', 'Paclitaxel'], 'is_context_needed': True}]

The high incidence of imported malaria ( 0.70 % ) and the low costs of providing chemoprophylaxis resulted in a cost-benefit ratio of 0.19 for chloroquine and proguanil and 0.57 for a regimen containing mefloquine .

[{'class': 'POS', 'spans': ['chloroquine', 'proguanil'], 'is_context_needed': False}]

Clinical trials suggest reduced benefit from the combination of cetuximab with oxaliplatin .

[{'class': 'NEG', 'spans': ['cetuximab', 'oxaliplatin'], 'is_context_needed': False}]

L-carnitine was administered 1 h before doxorubicin injection and daily thereafter for 15 days .

[{'class': 'POS', 'spans': ['L-carnitine', 'doxorubicin'], 'is_context_needed': True}]

New chemotherapeutic agents such as gemcitabine appear to have the potential to produce better results than those achieved over the last 35 years with fluorouracil .

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Comparative effectiveness of rituximab , abatacept , and tocilizumab in adults with rheumatoid arthritis and inadequate response to TNF inhibitors : prospective cohort study .

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Recoveries of both amino acids were increased bilaterally by local perfusion with veratridine ( 100 microM , given under halothane anaesthesia ) , pretreatment with reserpine ( 4 mg/kg , i.p . , 24 h beforehand ) , unilateral pretreatment of the medial forebrain bundle with 6-OHDA ( 8 microg/4 microl ) , and by the systemic ( 1 mg/kg , i.p . ) or bilateral intrastriatal ( 7 microg/0.5 microl under halothane anaesthesia ) administration of the dopamine D2 receptor antagonist haloperidol , but not raclopride ( 2 mg/kg , i.p . ) .

[{'class': 'POS', 'spans': ['reserpine', 'veratridine'], 'is_context_needed': False}, {'class': 'POS', 'spans': [3, 5], 'is_context_needed': False}, {'class': 'NEG', 'spans': [5, 6], 'is_context_needed': False}]

Combined initial cyclophosphamide with repeated methylprednisolone pulse therapy for severe paraquat poisoning from dermal exposure .

[{'class': 'POS', 'spans': ['cyclophosphamide', 'methylprednisolone'], 'is_context_needed': True}]

These adverse effects were all more frequent than with docetaxel or pemetrexed .

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Hyper-CVAD , given in odd-number courses ( Courses 1 , 3 , 5 , and 7 ) , was alternated with methotrexate and cytarabine ( MTX/Ara-C ) , given in even-number courses ( Courses 2 , 4 , 6 , and 8) .

[{'class': 'POS', 'spans': ['methotrexate', 'cytarabine'], 'is_context_needed': True}]

Despite systemic chemotherapy combining pemetrexed , bevacizumab and Cisplatinum , the disease relapsed eight months later with multiple metastatic lung nodules leading to a treatment shift .

[{'class': 'NEG', 'spans': ['pemetrexed', 'bevacizumab', 'Cisplatinum'], 'is_context_needed': False}]

Trastuzumab , which is still the first-line therapy in breast cancer , increases the pCR rate more than lapatinib .

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Recently , several novel agents are under clinical development for advanced colorectal cancer , including irinotecan , oxaliplatin , oral fluoropyrimidines , raltitrexed , monoclonal antibody 17 - 1A and tumour vaccines .

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Pretreatment with NaHCO3 , NH4Cl , SKF 525A , piperonyl butoxide , progesterone , cysteamine , phenobarbital or metyrapone prior to the administration of [methyl-14C]nicotine was studied .

[{'class': 'POS', 'spans': ['[methyl-14C]nicotine', 'metyrapone'], 'is_context_needed': True}, {'class': 'POS', 'spans': [8, 4], 'is_context_needed': True}]

Capecitabine is an oral pro-drug of fluorouracil .

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However , the current artemisinin FDC products , such as β-artemether and lumefantrine , are inherently unstable and require controlled distribution and storage conditions , which are not always available in resource-limited settings .

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Because the mass invaded the pancreas and superior mesenteric vein as well as duodenum and the disease was disseminated to liver and peritoneum , she received palliative chemotherapy using vincristine , doxorubicin , cyclophosphamide , ifosfamide , and etoposide .

[{'class': 'POS', 'spans': ['vincristine', 'doxorubicin', 'cyclophosphamide', 'ifosfamide', 'etoposide'], 'is_context_needed': False}]

In HCV genotype 1 infection and F3 or F4 liver fibrosis , treatment with boceprevir or telaprevir in addition to pegylated interferon and ribavirin is recommended .

[{'class': 'POS', 'spans': ['boceprevir', 'pegylated interferon', 'ribavirin'], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 2, 3], 'is_context_needed': False}]

Membrane-modifying agents such as reserpine , calcium antagonists ( nicardipine , verapamil ) and calmodulin inhibitor ( trifluoperazine ) were found to enhance the cytotoxicity of ACNU in vitro and in vivo in ACNU-resistant C 6 ( C 6/ACNU ) glioma .

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To investigate the efficacy of temozolomide in relation to response rate , toxicity , time to progression . and median survival time , a phase II study was conducted in patients with recurrent high-grade glioma following surgery plus radiotherapy and first-line chemotherapy based on nitrosourea , procarbazine and vincristine .

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Ketoconazole inhibited the entire pathway , while exposure to genistein resulted in increased hormone levels upstream of 3-β-hydroxysteroid dehydrogenase ( 3β-HSD ) and decreases downstream .

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Melphalan , cisplatin , carboplatin , doxorubicin , and etoposide cytotoxicities were determined by DIMSCAN assay .

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As a treatment at the time of progression after pemetrexed-based chemotherapy , erlotinib conferred a survival benefit when compared to docetaxel ( p=0.024 ; hazard ratio , 0.377 ) .

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The combination of ifosfamide with oral etoposide appears to have significant but manageable toxicity and encouraging efficacy in platinum resistant ovarian cancer .

[{'class': 'POS', 'spans': ['ifosfamide', 'etoposide'], 'is_context_needed': False}]

After switching from ranibizumab treatment to aflibercept , ORTs remained present in 75 % of eyes , and significant reductions in CMT , PED , and SRF , and presence of intraretinal cysts were observed .

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Vinorelbine , gemcitabine , docetaxel , paclitaxel , and irinotecan are all new chemotherapeutic agents which have shown promising activity in this disease .

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This Phase I , randomized , open-label study evaluated the gastric pH-altering effects of omeprazole , a proton pump inhibitor , and the CYP3A enzyme/P-glycoprotein (Pgp)-inhibitory effects of ritonavir , an HIV protease inhibitor , on the pharmacokinetics and safety of the hepatitis C virus ( HCV ) non-structural protein 5A ( NS5A ) inhibitor GSK2336805 in healthy male and female subjects .

[{'class': 'POS', 'spans': ['omeprazole', 'ritonavir', 'GSK2336805'], 'is_context_needed': True}]