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Neoadjuvant therapy with gemcitabine plus doxorubicin results in a high tumor response rate with moderate oral and hematologic toxicity . | [{'class': 'POS', 'spans': ['gemcitabine', 'doxorubicin'], 'is_context_needed': False}] |
Treatment of invasive sphenoidal aspergillosis is surgical , followed by antifungal therapy , mostly amphotericin B. To optimize the adjuvant antifungal treatment , which is often limited by severe side effects , the new triazole antifungal agent voriconazole with broad coverage of fungal pathogens including Aspergillus was investigated in a study of 4 patients with clinical , radiological and histological signs of invasive sphenoidal aspergillosis . | [] |
At cross over the ORR was 0 % and 18 % on cross over to vinorelbine and docetaxel respectively with a median TTP of 17.3 weeks ( 95 % CI , 16.3 - 18.1 ) and 18.7 weeks ( 95 % CI , 13.9 - 23.4 ) for those receiving vinorebine and docetaxel at cross over respectively . | [] |
The drugs approved in Europe for the systemic treatment of herpes zoster are aciclovir , valaciclovir , famciclovir and brivudine . | [] |
In this parallel group , randomized , double-blind study , 301 PD patients , the majority with motor fluctuations , received entacapone ( 200 mg ) or placebo with each daily dose of standard or controlled-release ( CR ) levodopa . | [{'class': 'POS', 'spans': ['entacapone', 'levodopa'], 'is_context_needed': True}] |
Importance of adding neomycin to metronidazole for bowel preparation . | [{'class': 'POS', 'spans': ['neomycin', 'metronidazole'], 'is_context_needed': False}] |
The effects of metformin ( MET ) and curcumin ( CUR ) single treatments have been tested against breast cancer ; however , their combination has not been explored . | [] |
Warfarin was associated with a significantly higher risk of MB ( HR = 1.52 , 95 % CI = 1.14 - 2.04 ) , CRNM bleeding ( HR = 1.27 , 95 % CI = 1017.15 - 1.40 ) , and recurrent VTE ( HR = 1.50 , 95 % CI = 1.24 - 1.82 ) compared with apixaban . | [] |
A combination chemotherapy regimen containing mitomycin-C ( 10 mg/m2 , day 2 ) , vincristine ( 0.5 mg/m2 , days 1 and 4 ) , bleomycin ( 30 U QD , days 1 - -4 as a continuous intravenous infusion during courses one and two only ) , and cis-platinum ( 50 mg/m2 , days 1 and 22 ) was administered every 6 weeks to 14 evaluable patients with advanced ( i.e. , Stage IVB ) and/or recurrent squamous cell carcinoma of the cervix . | [{'class': 'POS', 'spans': ['mitomycin-C', 'vincristine', 'bleomycin', 'cis-platinum'], 'is_context_needed': True}] |
Co-injection of the lowest doses of levobupivacaine and lidocaine dramatically increased the paw withdrawal latency . | [{'class': 'NEG', 'spans': ['levobupivacaine', 'lidocaine'], 'is_context_needed': True}] |
Inflammatory breast cancer ( IBC ) is a rare , aggressive form of breast cancer associated with HER2 amplification , with high risk of metastasis and an estimated median survival of 2.9 y. We performed an open-label , single-arm phase II clinical trial ( ClinicalTrials.gov NCT01325428 ) to investigate the efficacy and safety of afatinib , an irreversible ErbB family inhibitor , alone and in combination with vinorelbine in patients with HER2-positive IBC . | [{'class': 'POS', 'spans': ['afatinib', 'vinorelbine'], 'is_context_needed': True}] |
Carboplatin and paclitaxel versus cisplatin , paclitaxel and doxorubicin for first-line chemotherapy of advanced ovarian cancer : a Hellenic Cooperative Oncology Group ( HeCOG ) study . | [{'class': 'POS', 'spans': ['Carboplatin', 'paclitaxel'], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 3, 4], 'is_context_needed': True}] |
For susceptibility testing , DS-8587 exhibited more effective antibacterial activity when compared with ciprofloxacin and levofloxacin . | [{'class': 'NEG', 'spans': ['ciprofloxacin', 'levofloxacin'], 'is_context_needed': False}] |
Since 1987 , we have evaluated carboplatin alone or in combination with etoposide in two separate phase II trials of patients with non-small cell lung cancer ( NSCLC ) who had not received prior chemotherapy . | [{'class': 'COMB', 'spans': ['carboplatin', 'etoposide'], 'is_context_needed': True}] |
Oral formulations of paclitaxel and docetaxel are of great interest , but have yet to receive regulatory approval in this disease . | [] |
FLAIE ( fludarabine , cytarabine , idarubicin , and etoposide ) , a four drug induction chemotherapy for adult acute myeloid leukemia : A single center experience . | [{'class': 'COMB', 'spans': ['fludarabine', 'cytarabine', 'idarubicin', 'etoposide'], 'is_context_needed': True}] |
Overall , our study shows that the combination of dabrafenib and cetuximab results in increased antitumor activity and decreased stem cell capacities in BRAF(V600E)-mutant CRC cells . | [{'class': 'POS', 'spans': ['dabrafenib', 'cetuximab'], 'is_context_needed': False}] |
Forty-seven patients with previously untreated metastatic or unresectable colorectal adenocarcinoma received capecitabine 1000 mg/m2 twice daily on days 2 - 15 and intravenous irinotecan 100 mg/m2 on days 1 and 8 , every 21 days . | [{'class': 'POS', 'spans': ['capecitabine', 'irinotecan'], 'is_context_needed': True}] |
Amphotericin B plus flucytosine were initially given to 4 patients , all of them developed liver and renal abnormalities to some degree after therapy . | [{'class': 'NEG', 'spans': ['Amphotericin', 'flucytosine'], 'is_context_needed': False}] |
Liposomes were surface modified with transferrin ( Tf ) for receptor targeting , and cell penetrating peptide PFVYLI ( PFV ) to increase translocation of doxorubicin ( Dox ) and Erlotinib ( Erlo ) across the BBB into glioblastoma ( U87 ) tumor cells . | [{'class': 'POS', 'spans': ['doxorubicin', 'Erlotinib'], 'is_context_needed': True}] |
Endpoints were determination of maximum tolerated dose of doxorubicin and etoposide , treatment tolerability , and survival . | [{'class': 'POS', 'spans': ['doxorubicin', 'etoposide'], 'is_context_needed': True}] |
Multiple ongoing clinical trials are currently evaluating the role of immune checkpoint inhibitors in ACC ( pembrolizumab , combination pembrolizumab and relacorilant , nivolumab , combination nivolumab and ipilimumab ) . | [{'class': 'COMB', 'spans': ['pembrolizumab', 'relacorilant'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [4, 5], 'is_context_needed': True}] |
Treatments including the monoclonal antibodies showed a cost per month of PFS gained of 2823 € ( FOLFIRI with cetuximab in KRAS wild-type patients and liver-only metastases ) , of € 15,822 ( FOLFOX with panitumumab in KRAS wild type ) , and of 13,383 € ( FOLFOX with bevacizumab ) . | [] |
Several liposomal anthracyclines have been extensively studied in humans with a variety of cancer types , including TLC D-99 ( Myocet ; The Liposome Company , Elan Corporation , Princeton , NJ ) , liposomal daunorubicin ( Daunoxome ; NeXstar Pharmaceuticals , Inc , San Dimas , CA ) , and pegylated liposomal doxorubicin ( Doxil ; Alza Pharmaceuticals , Palo Alto , CA , Caelyx ; Schering Corporation , Kenilworth , NJ ) . | [] |
In this study , combined drug action from the combination of Oxa with the phytochemicals andrographolide ( Andro ) , epigallocatechin-3-gallate ( EGCG ) , chlorophyllin ( Chl ) , colchicines ( Col ) , curcumin ( Cur ) and paclitaxel ( Tax ) was evaluated in the human ovarian cancer cell lines A2780 and A2780(cisR ) . | [] |
Bevacizumab and intetumumab can be administered safely in combination . | [{'class': 'POS', 'spans': ['Bevacizumab', 'intetumumab'], 'is_context_needed': False}] |
The key findings were that amsacrine produced comparable levels of cell killing with both alpha and beta , whilst etoposide , doxorubicin and mitoxantrone produced higher degrees of cell killing with alpha than with beta or yeast topoisomerase II . | [] |
In the full study population , there were significant improvements in the anastrozole group compared with the tamoxifen group for disease-free survival ( hazard ratio [ HR ] 0·91 , 95 % CI 0·83 - 0·99 ; p=0·04 ) , time to recurrence ( 0·84 , 0·75 - 0·93 ; p=0·001 ) , and time to distant recurrence ( 0·87 , 0·77 - 0·99 ; p=0·03 ) . | [] |
The optimal correlation coefficients for norfloxacin , enrofloxacin , and ofloxacin in the prediction set were obtained with multiple linear regression that combined absorption peaks with wavelengths selected by stepwise regression , which were 0.867 , 0.828 , and 0.964 , respectively . | [] |
The protocol consisted of oral gefitinib 250 mg daily for 1 year plus intravenous oxaliplatin 85 or 100 mg/m(2 ) on days 1 , 15 , and 29 , and RT ( 50.4 Gy in 28 1.8-Gy fractions ) . | [{'class': 'COMB', 'spans': ['gefitinib', 'oxaliplatin'], 'is_context_needed': True}] |
The efflux curves observed for both verapamil and prochlorperazine could be mathematically modeled by assuming | [] |
The in vitro concentration-effect relationships for , chloroquine , mefloquine , lumefantrine and artesunate , were derived from clinical isolates obtained from patients on the western border of Thailand . | [] |
Forty-eight patients were treated with mitoxantrone alone , 40 with mitoxantrone plus beta-interferon , 11 with fluorouracil plus folinic acid and the remaining four with adriamycin . | [{'class': 'COMB', 'spans': ['mitoxantrone', 'beta-interferon'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [2, 3], 'is_context_needed': True}] |
Fifty-one HIV-negative patients with an average age of 50.3 years were treated with chemotherapy regimen included 2500 mg/m(2 ) MTX with Leucovorin rescue and 1.4 mg/m(2 ) vincristine ( day two ) , which was administered every other week for 6 weeks . | [{'class': 'COMB', 'spans': ['Leucovorin', 'vincristine'], 'is_context_needed': True}] |
Phase I study of decitabine with doxorubicin and cyclophosphamide in children with neuroblastoma and other solid tumors : a Children 's Oncology Group study . | [{'class': 'NEG', 'spans': ['decitabine', 'doxorubicin'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [0, 2], 'is_context_needed': True}] |
Tail-flick test showed that tramadol produced better antinociceptive effect than gabapentin . | [] |
Our study involves a preliminary phase II trial , which evaluates the activity , feasibility and tolerability of a sequential combination of docetaxel and gemcitabine followed by docetaxel and carboplatin , as first-line treatment for inoperable NSCLC . | [{'class': 'POS', 'spans': ['docetaxel', 'gemcitabine', 'carboplatin'], 'is_context_needed': True}] |
The combination of galunisertib and sorafenib showed acceptable safety and a prolonged OS outcome . | [{'class': 'POS', 'spans': ['galunisertib', 'sorafenib'], 'is_context_needed': False}] |
All the patients were conditioned with busulfan ( BU ) 12 mg.kg-1 and cyclophosphamide ( CY ) 3.6 g.m-2 , of whom 4 were conditioned with additioned antithymocyte globulin(ATG ) . | [{'class': 'POS', 'spans': ['busulfan', 'cyclophosphamide', 'antithymocyte globulin(ATG'], 'is_context_needed': True}] |
Phase II study of an intensive combination chemotherapy with cisplatin , adriamycin , etoposide and cyclophosphamide ( CAVE ) in small cell lung cancer . | [{'class': 'POS', 'spans': ['cisplatin', 'adriamycin', 'etoposide', 'cyclophosphamide'], 'is_context_needed': False}] |
These trials were compared with a broader set of trials examining the effectiveness of other AADs for AF : amiodarone , sotalol and class 1c agents ( flecainide and propafenone ) . | [] |
First-line PFS for sorafenib , sunitinib , temsirolimus , everolimus , and " other " was 6.9 , 8.9 , 4.2 , not analyzed ( too few patients ) , and 10.8 months , respectively . | [] |
Simultaneous treatment with gefitinib and pemetrexed enhanced cell growth inhibition and cell death and prevented the appearance of gefitinib resistance mediated by T790 M mutation or epithelial-to-mesenchymal transition ( EMT ) in PC9 and HCC827 cells , respectively . | [{'class': 'POS', 'spans': ['gefitinib', 'pemetrexed'], 'is_context_needed': False}] |
Two courses of eight drugs in 1 day followed by two courses of etoposide plus carboplatin ( 500 and 800 mg/m(2 ) per course , respectively ) were administered after surgery . | [{'class': 'POS', 'spans': ['etoposide', 'carboplatin'], 'is_context_needed': True}] |
Azithromycin , doxycycline , and moxifloxacin hydrochloride were shown to relieve symptoms but were not as effective after continuous usage . | [] |
Travellers used doxycycline ( 15 % ) for malaria prophylaxis , 11 % took an antibiotic for travellers ' diarrhoea ( TD ) treatment ( fluoroquinolone 7 % , azithromycin 4 % ) . | [] |
3 . When timolol was administered concomitantly with hydrochlorothiazide , plasma renin activity was suppressed and blood pressure was significantly lowered . | [{'class': 'POS', 'spans': ['timolol', 'hydrochlorothiazide'], 'is_context_needed': False}] |
Phase I study combining treatment with temsirolimus and sunitinib malate in patients with advanced renal cell carcinoma . | [{'class': 'NEG', 'spans': ['temsirolimus', 'sunitinib'], 'is_context_needed': True}] |
Both anastrozole ( 1.0 mg/d ) and letrozole ( 2.5 mg/d ) have now been approved as second-line treatment for hormone-dependent breast cancer in postmenopausal women in whom disease has progressed following tamoxifen treatment . | [] |
P-glycoprotein effluxes a variety of anticancer drugs , such as doxorubicin , vinca alkaloids , etoposide and taxol , and thereby allows cancer cells to show resistance to these drugs . | [] |
The H2-receptor antagonists dose-dependently inhibited the histamine-stimulated acid production ( IC50 for cimetidine = 10(-5 ) M and 10(-6 ) M and for ranitidine = 10(-5 ) M and 2 X 10(-7 ) M for high and low concentrations of histamine , respectively ) . | [] |
To examine the cost-effectiveness of aripiprazole , quetiapine , and olanzapine/fluoxetine in adults with MDD who are refractory to antidepressant therapy . | [] |
2 . The two combination treatment regimes lowered the 12 h post-dose blood pressure more effectively than did atenolol alone , but the high dose nifedipine combination was no more effective than the low dose nifedipine combination . | [{'class': 'POS', 'spans': ['atenolol', 'nifedipine'], 'is_context_needed': True}] |
In addition , a variety of systemic chemotherapeutic agents have been tested in HCC , including various combinations of 5-fluorouracil , doxorubicin , epirubicin , etoposide , cisplatin , and mitoxantrone , as well as interferon , tamoxifen , capecitabine , thalidomide , and octreotide . | [] |
A very reasonable first-choice antidepressant is either sertraline or paroxetine . | [] |
It is concluded that plasma lipid regulators which elevate HDL in this model might do so by altering the metabolism and hence plasma concentration of apoAI ( fenofibrate , ciprofibrate ) or both apo E and A-I ( gemfibrozil ) . | [] |
To evaluate the effect of switching to bevacizumab or ranibizumab after developing tachyphylaxis during anti-vascular endothelial growth factor ( VEGF ) therapy for choroidal neovascularisation ( CNV ) . | [] |
Low-risk patients received three cycles of modified CODOX-M ( cyclophosphamide , doxorubicin , adriamycin , vincristine with intrathecal methotrexate and cytarabine followed by high-dose systemic methotrexate , regimen A ) . | [{'class': 'POS', 'spans': ['cyclophosphamide', 'doxorubicin', 'vincristine', 'methotrexate', 'cytarabine', 'adriamycin'], 'is_context_needed': True}] |
Background The National Wilms Tumor Study ( NWTS ) approach to treating stage III favorable-histology Wilms tumor ( FHWT ) is Regimen DD4A ( vincristine , dactinomycin , and doxorubicin ) and radiation therapy . | [{'class': 'POS', 'spans': ['vincristine', 'doxorubicin', 'dactinomycin'], 'is_context_needed': True}] |
The role of serotonergic neurons in foot shock-induced jumping behavior was evaluated by studying the effects of serotonin agonists and depletors under conditions of increasing activity of catecholaminergic neurons by combining different shock intensities with methamphetamine or clonidine pretreatment . | [] |
Enrolled patients received ADT in the form of leuprolide every 12 weeks for 24 months with bicalutamide initiating after the completion of chemotherapy . | [{'class': 'POS', 'spans': ['leuprolide', 'bicalutamide'], 'is_context_needed': True}] |
Clinical studies have indicated the following relative potency differences : fluticasone propionate > budesonide = beclomethasone dipropionate > triamcinolone acetonide = flunisolide . | [] |
To evaluate the efficacy and safety of lapatinib ( L ) and trastuzumab ( T ) combination in HER2-positive metastatic breast cancer ( MBC ) patients previously treated with T and/or L. | [{'class': 'POS', 'spans': ['lapatinib', 'trastuzumab'], 'is_context_needed': True}] |
Meloxicam combined with sorafenib synergistically inhibits tumor growth of human hepatocellular carcinoma cells via ER stress-related apoptosis . | [{'class': 'POS', 'spans': ['Meloxicam', 'sorafenib'], 'is_context_needed': False}] |
We validated these initial findings in samples collected in a clinical trial comparing the nucleoside analog fludarabine alone or in combination with the alkylating agent cyclophosphamide in untreated CLL samples collected prior to starting therapy ( E2997 ) . | [{'class': 'COMB', 'spans': ['fludarabine', 'cyclophosphamide'], 'is_context_needed': True}] |
The antiviral agents ganciclovir and foscarnet are effective against CMV retinitis and gastrointestinal diseases , although dose-limiting adverse effects and the need for long-term maintenance therapy may hinder their use in many patients . | [] |
Switching between metronidazole and clarithromycin seems to be a sensible strategy as these two are the most effective anti-Helicobacter agents . | [] |
Therefore , downregulation of bcl-2 or xIAP by RNAi enhances the effects of etoposide and doxorubicin . | [] |
Cetuximab is a monoclonal antibody against EGFR with additive preclinical activity with irinotecan . | [{'class': 'POS', 'spans': ['Cetuximab', 'irinotecan'], 'is_context_needed': False}] |
A non-specific inhibitor of 5-HT reuptake , imipramine , did not produce this amnesic effect , nor did the combination of fenfluramine with the MAOI tranylcypromine , although it produced , as expected , the " serotonergic syndrome . " Results for the metabolic precursor of 5-HT , 5-HTP , also administered peripherally , were inconsistent , with amnesic effects seen at 5 and 20 mg/kg but none at 10 mg/kg . | [{'class': 'NEG', 'spans': ['fenfluramine', 'tranylcypromine'], 'is_context_needed': False}] |
Activity of irinotecan and temozolomide in the presence of O6-methylguanine-DNA methyltransferase inhibition in neuroblastoma pre-clinical models . | [{'class': 'POS', 'spans': ['irinotecan', 'temozolomide'], 'is_context_needed': True}] |
This is a phase II study of etoposide , vincristine , and doxorubicin , administered as a 96-hour continuous infusion , with intravenous ( IV ) bolus cyclophosphamide and oral prednisone ( EPOCH ) in 74 consecutive patients who relapsed from or failed to respond to most of the same drugs administered on a bolus schedule . | [{'class': 'POS', 'spans': ['etoposide', 'vincristine', 'doxorubicin', 'cyclophosphamide', 'prednisone'], 'is_context_needed': True}] |
Based on the FIRM-ACT trial , mitotane plus etoposide , doxorubicin , and cisplatin is now the established first-line cytotoxic therapy . | [{'class': 'POS', 'spans': ['mitotane', 'etoposide', 'doxorubicin', 'cisplatin'], 'is_context_needed': False}] |
Additionally , thorough analysis of the available literature indicates no correlation between dasatinib nor nilotinib dose , length of exposure , trimester of use , and deleterious patient or fetal outcomes can be concluded . | [] |
The principal toxicity was myelosuppression ; grade 4 neutropenia was more frequent with topotecan ( 81.4 % of patients ) than with paclitaxel ( 22.9 % of patients ) . | [] |
Consistent with previous reports , genistein combined with doxorubicin had a synergistic effect on MCF-7/Adr cells , and genistein reduced the chemoresistance of these cells . | [{'class': 'POS', 'spans': ['genistein', 'doxorubicin'], 'is_context_needed': False}] |
This historical cohort study evaluated the association of efavirenz ( EFV ) compared to nevirapine ( NVP ) with post-ART TB among patients initiated on first-line ART from 2005 to 2009 in a large , urban HIV clinic in Uganda . | [] |
Combination of ibrutinib and ublituximab ( n = 64 ) had an ORR of 78 % ( CR 7 % ) in a phase 3 study . | [{'class': 'POS', 'spans': ['ibrutinib', 'ublituximab'], 'is_context_needed': True}] |
Overall median effective concentration ( EC50 ) values ranged from 0.22 mg/L to 86 mg/L. Pseudomonas putida was the most sensitive organism ( EC50 values for 16-h growth inhibition were 0.22 and 0.82 mg/L for oxytetracycline and flumequine , respectively ) , followed by duckweed Lemna minor ( 7-d growth inhibition , EC50 2.1 and 3.0 mg/L ) and green alga Pseudokirchneriella subcapitata ( 4-d growth inhibition , EC50 3.1 and 2.6 mg/L ) . | [] |
This review therefore aims to overview the prognostic value of MRD eradication in CLL , the role of post-remission intervention with " passive " immunotherapy ( alemtuzumab or rituximab ) so as to eliminate persistent MRD or prevent MRD relapse , the impact of these strategies on disease-free survival and their possible adverse consequences . | [] |
Paclitaxel , 5-fluorouracil , hydroxyurea , and concomitant radiation therapy for poor-prognosis head and neck cancer . | [{'class': 'NEG', 'spans': ['Paclitaxel', '5-fluorouracil', 'hydroxyurea'], 'is_context_needed': True}] |
The results suggest that the superior efficacy of nivolumab plus ipilimumab over sunitinib was maintained in intermediate-risk or poor-risk and intention-to-treat patients with extended follow-up , and show the long-term benefits of nivolumab plus ipilimumab in patients with previously untreated advanced renal cell carcinoma across all risk categories . | [{'class': 'POS', 'spans': ['nivolumab', 'ipilimumab'], 'is_context_needed': False}] |
Clonogenic assays showed that preexposure to hypoxia leads to resistance to various classes of chemotherapeutic agents , including anthracyclines ( daunorubicin and doxorubicin ) , epipodophyllotoxins ( etoposide ) , and anthracenediones ( mitoxantrone ) . | [] |
Hence , the aim of this study was to conduct an economic evaluation of anastrozole versus tamoxifen in early stage breast cancer . | [] |
A randomized trial of mobilization of peripheral blood stem cells with cyclophosphamide , etoposide , and granulocyte colony-stimulating factor with or without cisplatin in patients with malignant lymphoma receiving high-dose chemotherapy . | [{'class': 'NEG', 'spans': ['cyclophosphamide', 'etoposide', 'cisplatin'], 'is_context_needed': True}] |
Treatment of pancreatic cancer with a combination of docetaxel , gemcitabine and granulocyte colony-stimulating factor : a phase II study of the Greek Cooperative Group for Pancreatic Cancer . | [{'class': 'POS', 'spans': ['docetaxel', 'gemcitabine'], 'is_context_needed': True}] |
Such situations are known as exposing to pneumococcal meningitis and to resistance of the strain involved to penicillin G. Both patients were cured by vancomycin in continuous infusion associated with rifampicin or fosfomycin . | [{'class': 'POS', 'spans': ['vancomycin', 'rifampicin', 'fosfomycin'], 'is_context_needed': True}] |
We recently identified a unique site within the MLL bcr that is highly susceptible to DNA double-strand cleavage by classic topo II inhibitors ( e.g. , etoposide and doxorubicin ) . | [] |
In 2011 , the combination of rituximab with bendamustine ( 31 % ) was most frequent used followed by the rituximab-fludarabine-cyclophosphamide ( 22 % ) regime . | [{'class': 'POS', 'spans': ['rituximab', 'bendamustine'], 'is_context_needed': True}] |
The combination of ofatumumab and bendamustine in elderly patients with diffuse large B-cell lymphoma demonstrated modest efficacy compared with standard of care . | [{'class': 'POS', 'spans': ['ofatumumab', 'bendamustine'], 'is_context_needed': False}] |
Imatinib and nilotinib directly inhibit the kinase activity of KIT , while RAD001 ( everolimus ) inhibits mTOR . | [] |
In this study the antiproliferative effects of Paclitaxel ( PAC ) , Epirubicin ( EPI ) and Tamoxifen ( TAM ) on growth kinetics of Ehrlich Ascites Tumor ( EAT ) cells were examined in culture . | [] |
The most common chemotherapy and route of administration for systemic treatment is paclitaxel plus carboplatin given intravenously . | [{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': False}] |
Finally , the ability of givinostat , belinostat and panobinostat to reactivate latent HIV-1 expression in primary T-cells was investigated employing a CCL19-induced latent primary CD4 + T cell infection model . | [] |
Aflibercept has been used in combination with folinic acid (leucovorin)-fluorouracil-irinotecan ( FOLFIRI ) chemotherapy in mCRC patients and among patients with mCRC with wild-type KRAS , the outcomes were significantly improved by panitumumab in combination with folinic acid (leucovorin)-fluorouracil-oxaliplatin ( FOLFOX ) or FOLFIRI . | [{'class': 'POS', 'spans': ['panitumumab', 'folinic acid'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 1], 'is_context_needed': True}] |
The current mainstay of systemic treatment for patients with metastatic or unresectable disease remains doxorubicin with or without ifosfamide in the first-line setting . | [{'class': 'POS', 'spans': ['doxorubicin', 'ifosfamide'], 'is_context_needed': False}] |
All patients received intravenous heparin after PTCA and aspirin was begun on the day prior to PTCA . | [] |
In this article , we summarize available literature evidence on different chemotherapy agents used beyond the first-line , in locally advanced or MBC patients , including rechallenge with anthracyclines and taxanes , antimetabolite and antimicrotubule agents , such as vinorelbine , capecitabine , eribulin , ixabepilone , and the newest developed agents , such as vinflunine , irinotecan , and etirinotecan . | [] |
After an initial 6 - 8 weeks of metformin , they received either letrozole ( 2.5 mg ) or clomiphene ( 100 mg ) from day 3 - 7 of their menstrual cycle . | [{'class': 'POS', 'spans': ['metformin', 'letrozole'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}] |
No study has evaluated the significance of CD30 expression in DLBCL patients treated with rituximab , etoposide , prednisone , vincristine , cyclophosphamide , and doxorubicin ( R-EPOCH ) . | [{'class': 'COMB', 'spans': ['rituximab', 'etoposide', 'prednisone', 'vincristine', 'cyclophosphamide', 'doxorubicin'], 'is_context_needed': True}] |
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