bala1524/Drug_Combination_Extraction · Datasets at Hugging Face

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This document attempts to provide reasonable guidance for the use of antimicrobials which have uncertain benefit but may increase risk of QT interval prolongation and ventricular proarrhythmia , notably , chloroquine , hydroxychloroquine , azithromycin , and lopinavir/ritonavir .	[]
Phase II study of weekly paclitaxel and sorafenib as second/third-line therapy in patients with adrenocortical carcinoma .	[{'class': 'NEG', 'spans': ['paclitaxel', 'sorafenib'], 'is_context_needed': True}]
This study indicates that cyclophosphamide , doxorubicin , and methotrexate are , at best , marginally active as single agents , and new drugs with more efficacy are needed before combination chemotherapy can be expected to result in any meaningful prolongation of survival in non-small cell lung cancer .	[{'class': 'POS', 'spans': ['cyclophosphamide', 'doxorubicin', 'methotrexate'], 'is_context_needed': True}]
The combined treatment of curcumin and docetaxel inhibited the proliferation and induced apoptosis significantly higher than the curcumin and docetaxel-treated group alone .	[{'class': 'POS', 'spans': ['curcumin', 'docetaxel'], 'is_context_needed': False}]
Previously , a study of ours showed that the combination of dabrafenib and trametinib improves progression-free survival compared with dabrafenib and placebo in patients with BRAF Val600Lys/Glu mutation-positive metastatic melanoma .	[{'class': 'POS', 'spans': ['dabrafenib', 'trametinib'], 'is_context_needed': False}]
compared to those for rats treated with trovafloxacin or clindamycin plus gentamicin	[{'class': 'NEG', 'spans': ['clindamycin', 'gentamicin'], 'is_context_needed': True}]
We suggest topoisomerase II inhibition by Aroclor 1254 , trovafloxacin , doxorubicin , and etoposide to be responsible for significant co-localization of regulated genes through the inability of the stabilized enzyme complexes to religate DNA .	[]
All but one received two induction courses of the 3 day-AVI ( doxorubicin 50 mg/m(2 ) day 1 , etoposide 120 mg/m(2 ) day 1 , 2 , 3 , ifosfamide 2000 mg/m(2 ) day 1 , 2 ) regimen .	[{'class': 'POS', 'spans': ['doxorubicin', 'etoposide', 'ifosfamide'], 'is_context_needed': True}]
Although anti-HER2 ( trastuzumab ) and anti-VEGFR ( ramucirumab ) may yield survival benefit , anti-EGFR and anti-HGFR therapies have failed to improve outcomes .	[]
In the phase I trial , 19 patients received bolus doxorubicin ( 50 mg/m2 ) followed after a 16-hour interval by paclitaxel ( given at dose levels ranging from 130 to 250 mg/m2 ) by 3-hour infusion every 3 weeks , for a maximum of eight cycles .	[{'class': 'POS', 'spans': ['doxorubicin', 'paclitaxel'], 'is_context_needed': True}]
New monoclonal antibodies ( ofatumumab ) , second-generation proteasome inhibitors ( carfilzomib ) , mammalian target of rapamycin inhibitors , and Bruton 's tyrosine kinase inhibitors are promising and may expand future treatment options .	[]
Exposure of LLC-PK1 cells to hydrogen peroxide ( 2.5 mM ) resulted in a significant increase in the bleomycin-detectable iron ( iron capable of catalyzing free radical reactions ) content that was prevented by cimetidine , but not ranitidine .	[{'class': 'POS', 'spans': ['hydrogen peroxide', 'cimetidine'], 'is_context_needed': False}, {'class': 'NEG', 'spans': [0, 2], 'is_context_needed': False}]
Patients who did or did not respond to previous DIMARD therapy either on i.m . gold , D-Penicillamine or Chloroquine , did usually well when treated with Auranofin , even if severe side effects leading to withdrawal had occurred on previous therapy .	[]
Patients were randomly assigned 1:1 centrally to either the docetaxel , prednisone , and custirsen combination or docetaxel and prednisone alone .	[{'class': 'POS', 'spans': ['docetaxel', 'prednisone', 'custirsen'], 'is_context_needed': True}]
[ Carboplatin and etoposide combination for the treatment of recurrent epithelial ovarian cancer ] .	[{'class': 'POS', 'spans': ['Carboplatin', 'etoposide'], 'is_context_needed': True}]
One-hour paclitaxel plus carboplatin in the treatment of advanced non-small cell lung cancer : results of a multicentre , phase II trial .	[{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': True}]
Preliminary data combining trastuzumab with the antiangiogenic antibody bevacizumab is encouraging ; this combination will be tested in both early stage and late stage disease .	[{'class': 'POS', 'spans': ['trastuzumab', 'bevacizumab'], 'is_context_needed': False}]
The immuno-oncology-based combinations with different types of immune checkpoint inhibitors ( PD-1/PD-L1 and CTLA-4 inhibitors such as nivolumab , pembrolizumab , atezolizumab , durvalumab , ipilimumab , tremelimumab ) , or the association of immune checkpoint inhibitors plus anti-angiogenic agents ( bevacizumab , lenvatinib , cabozantinib ) , have led to a breakthrough in the treatment of hepatocellular carcinoma .	[]
A decrease in VEGF-A expression in the tumor node and salivary gland was found after monotherapy with melatonin and cyclophosphamide and , especially , after combined treatment , which proves maximum therapeutic efficiency of combined administration of chemical agents with various mechanisms of action .	[{'class': 'POS', 'spans': ['melatonin', 'cyclophosphamide'], 'is_context_needed': False}]
The combination of rituximab , bendamustine , and cytarabine ( R-BAC ) was highly active in a pilot trial of mantle cell lymphoma , but its use was restricted by high haematological toxicity .	[{'class': 'POS', 'spans': ['rituximab', 'bendamustine', 'cytarabine'], 'is_context_needed': False}]
Despite treatment with PH specific therapy ( sildenafil , ambrisentan , and epoprostenol ) , her condition worsened rapidly with acute right heart failure ( RHF ) .	[{'class': 'COMB', 'spans': ['sildenafil', 'ambrisentan', 'epoprostenol'], 'is_context_needed': True}]
Data from the present study show the feasibility and tolerability of combination ixabepilone plus carboplatin , with ixabepilone administered on day 1 or on days 1 and 8 on a 21-day cycle .	[{'class': 'COMB', 'spans': ['ixabepilone', 'carboplatin'], 'is_context_needed': True}]
Compared to other glucose lowering agents except metformin , gliclazide was slightly more effective ( -0.13 % ( 95%CI : -0.25 , -0.02 , I(2 ) 55 % ) ) .	[]
Thirteen stage III B and 13 stage IV patients received intermediate doses of ifosfamide ( 1000 mg/m2 ) , carboplatin ( 120 mg/m2 ) and etoposide ( 120 mg/m2 ) given intravenously on day 1 to 3 every 4 weeks .	[{'class': 'POS', 'spans': ['ifosfamide', 'carboplatin', 'etoposide'], 'is_context_needed': True}]
This study compared immediate ( overnight ) and progressive switching to oxcarbazepine monotherapy in patients with partial seizures unsatisfactorily treated with carbamazepine monotherapy .	[]
In conclusion , prasugrel can be used successfully in most patients with a history of clopidogrel hypersensitivity .	[]
Fresh , clinical P. falciparum isolates were also tested in the presence of several drugs , including chloroquine , mefloquine , quinine , halofantrine , atovaquone and qinghaosu derivatives .	[]
The null hypothesis was there is no difference with respect to pain scores between ketorolac and iliac crest bupivacaine infusion as analgesic adjuncts to intravenous opioids .	[{'class': 'POS', 'spans': ['ketorolac', 'bupivacaine'], 'is_context_needed': True}]
Etoposide in combination with low-dose CAG ( cytarabine , aclarubicin , G-CSF ) for the treatment of relapsed or refractory acute myeloid leukemia : a multicenter , randomized control trial in southwest China .	[{'class': 'POS', 'spans': ['Etoposide', 'cytarabine', 'aclarubicin', 'G-CSF'], 'is_context_needed': True}]
were randomized in an open-label , crossover fashion to treatment A ( dolasetron 100 mg on day 1 ) and treatment B ( dolasetron 100 mg plus aprepitant 125 mg on day 1 , aprepitant 80 mg on days 2 - 3 ) .	[{'class': 'POS', 'spans': ['dolasetron', 'aprepitant'], 'is_context_needed': True}]
The regimen of gemcitabine combined with ifosfamide and anthracycline is feasible , tolerable and effective in patients with recurrent platinum resistant/refractory epithelial ovarian cancer .	[{'class': 'POS', 'spans': ['gemcitabine', 'ifosfamide', 'anthracycline'], 'is_context_needed': False}]
Second-line treatments consisted of cetuximab plus irinotecan for arm A , and oxaliplatin plus either 5-fluorouracil ( FOLFOX ) or capecitabine ( CapeOX ) for the control arms .	[{'class': 'POS', 'spans': ['cetuximab', 'irinotecan'], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 4], 'is_context_needed': True}]
In the UT-EC-1 cell line the growth inhibition was 72 % with paclitaxel , 54 % with carboplatin and 73 % with the combination of these compounds .	[{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': True}]
Several lines of evidence implicate serotonin ( 5-HT ) as the mediator of this enhancement : ( 1 ) Tranyclypromine-enhanced nicotine reinforcement was blocked by the 5-HT₂ receptor antagonists , ritanserin and ketanserin ; ( 2 ) parachloroamphetamine ( PCA ) , a 5-HT releaser , also enhanced nicotine self-administration in animals in which MAO activity was inhibited ; ( 3 ) pretreatment with tranylcypromine increased PCA-induced 5-HT overflow in the nucleus accumbens .	[{'class': 'COMB', 'spans': ['nicotine', 'ketanserin'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [2, 4], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 5], 'is_context_needed': True}]
Measurement and simulation results obtained in the batch experiments , spiked with the diclofenac and carbamazepine content of preclarified municipal wastewater shows comparably high biotransformation rates in the presence of growth substrates .	[]
Ursodeoxycholic acid is conjugated with taurine to promote secretin-stimulated biliary hydrocholeresis in the normal rat .	[{'class': 'POS', 'spans': ['Ursodeoxycholic acid', 'taurine'], 'is_context_needed': True}]
This study assessed the efficacy and safety of telaprevir in combination with peginterferon-α-2b ( PEG IFN ) and ribavirin ( RBV ) , for Japanese difficult-to-treat patients with hepatitis C virus ( HCV ) genotype 2 who had not achieved sustained virological response ( SVR ) during prior treatment .	[{'class': 'POS', 'spans': ['telaprevir', 'peginterferon-α-2b'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}]
The binding affinity profile of 5-HT1D binding sites [ 5-CT > 5-HT > d-LSD > 5-MeOT > sumatriptan > RU 24,969 > metergoline > tryptamine = rauwolscine = methylsergide > yohimbine = methiothepin > TFMPP = 8-OH-DPAT > 2-methyl-5-HT > mCPP = quipazine = CP 93,129 > ketanserin > (-)-propranolol = haloperidol = ipsapirone ] compares well to that reported for 5-HT1D receptor sites in human caudate and cortex ( correlation coefficient : 0.99 and 0.98 ) .	[]
The MX2 cells are cross-resistant to etoposide , teniposide , bisantrene , dactinomycin , 4'-(9-acridinylamino)methanesulfon-m-anisidide , and the anthracyclines daunorubicin and doxorubicin but retain sensitivity to the Vinca alkaloids melphalan and mitomycin C. In addition , the MX2 cells display slight collateral sensitivity to bleomycin .	[]
Combination of a betalactam antibiotic ( ampicillin or azlocillin ) or polymyxin B with rifampicin were studied with their administration in succession at various intervals in an experimental model of plague infection of albino mice .	[{'class': 'POS', 'spans': ['ampicillin', 'rifampicin'], 'is_context_needed': True}, {'class': 'POS', 'spans': [1, 3], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': True}]
Between August 1993 and September 1994 , 6010 patients were randomized to receive either reteplase ( n = 3004 ) or streptokinase ( n = 3006 ) .	[]
In patients coinfected and treated for both HIV-1 and hepatitis C virus ( HCV ) , administration of ribavirin ( RBV ) may result in altered intracellular drug levels of nucleoside reverse transcriptase inhibitors through inhibition of inosine 5'-monophosphate dehydrogenase .	[]
Previous treatments with rituximab and with rituximab plus high dose glucocorticoids , as well as with cyclophosphamide , azathioprine , plasma exchange , hyperbaric therapy , VAC therapy , prostacyclin , mycophenolate mofetil and surgery , had previously failed .	[{'class': 'NEG', 'spans': ['rituximab', 'glucocorticoids'], 'is_context_needed': False}, {'class': 'NEG', 'spans': [1, 2], 'is_context_needed': False}, {'class': 'NEG', 'spans': [1, 3], 'is_context_needed': False}]
The decision to test a triple combination has led to the development of Fansimef , a fixed combination with tablets containing 250 mg mefloquine , 500 mg sulfadoxine and 25 mg pyrimethamine .	[{'class': 'POS', 'spans': ['mefloquine', 'sulfadoxine', 'pyrimethamine'], 'is_context_needed': True}]
The aim of this study was to evaluate three active agents , bleomycin ( BLM ) , epirubicin and carboplatin in a new combination ( BECA ) in terms of feasibility , activity and toxicity in patients with recurrent and metastatic squamous cell carcinoma of the head and neck .	[{'class': 'POS', 'spans': ['bleomycin', 'epirubicin', 'carboplatin'], 'is_context_needed': True}]
Survival Benefits of Second-line Axitinib Versus Everolimus After First Line Sunitinib Treatment in Metastatic Renal Cell Carcinoma .	[]
A phase II trial of cytarabine , cisplatin , and etoposide was conducted in 38 patients with refractory stage III and IV non-Hodgkin 's lymphoma .	[{'class': 'COMB', 'spans': ['cytarabine', 'cisplatin', 'etoposide'], 'is_context_needed': True}]
The combination of camrelizumab plus gemcitabine and cisplatin has a manageable toxicity profile and promising preliminary antitumour activity for this disease in treatment-naive patients .	[{'class': 'POS', 'spans': ['camrelizumab', 'gemcitabine', 'cisplatin'], 'is_context_needed': False}]
His infection failed to respond to combinations of surgery , fluconazole and itraconazole .	[{'class': 'NEG', 'spans': ['fluconazole', 'itraconazole'], 'is_context_needed': True}]
The protective effect of tianeptine against PTZ seizures was mitigated when tianeptine was administered with naloxone .	[{'class': 'COMB', 'spans': ['tianeptine', 'naloxone'], 'is_context_needed': True}]
Twenty-one trials involving 3646 patients were included : 11 trials using beta-blockers ( 6 drugs ; 866 patients ) , 6 clonidine or mivazerol ( 614 patients ) , 3 diltiazem or verapamil ( 121 patients ) , and 1 nitroglycerin ( 45 patients ) .	[]
The sensitivity of human neuroblastoma-derived cell lines , cell line-derived , and patient-derived xenograft ( PDX ) models with varying ALK statuses to crizotinib combined with topotecan and cyclophosphamide ( topo/cyclo ) was examined .	[{'class': 'POS', 'spans': ['crizotinib', 'topotecan', 'cyclophosphamide'], 'is_context_needed': True}]
Patients were randomised to either receive additional tretinoin ( 45mg/m(2)/day ) for 12 weeks ( arm A ) , or peg-interferon and ribavirin alone ( arm B ) .	[{'class': 'COMB', 'spans': ['ribavirin', 'peg-interferon'], 'is_context_needed': True}]
This study sought to determine the efficacy and toxicity of weekly paclitaxel and carboplatin in CUP .	[{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': True}]
To investigate the presence of extended spectrum and metallo β-lactamases ( MBLs ) in Pseudomonas aeruginosa isolates which are resistant to imipenem and ceftazidime that were isolated in a hospital in Mexico .	[]
The patient achieved complete remission after two cycles of chemotherapy of daunorubicin , cytarabine and etoposide .	[{'class': 'POS', 'spans': ['daunorubicin', 'cytarabine', 'etoposide'], 'is_context_needed': False}]
We included 10 pharmacological ( modafinil , intravenous immunoglobulin ( IVIg ) , pyridostigmine , lamotrigine , amantadine , prednisone ) and three non-pharmacological ( muscle strengthening , rehabilitation in a warm climate ( that is temperature ± 25 ° C , dry and sunny ) and a cold climate ( that is temperature ± 0 ° C , rainy or snowy ) , static magnetic fields ) studies with a total of 675 participants with PPS in this review .	[]
Protection against CsA-induced PST cell death was afforded by reduction in extracellular calcium levels in the media or addition of the calcium entry antagonists : verapamil , nifedipine or diltiazem .	[]
This synergy was abrogated through siRNA knockdown of IkB. The synergistic effect of combining selinexor and bortezomib in vitro provides rationale for further investigation of this combination treatment for patients with high-risk neuroblastoma .	[{'class': 'POS', 'spans': ['selinexor', 'bortezomib'], 'is_context_needed': False}]
Therapy included 4 or 8 intensive therapy elements N1 ( Etoposide 125 mg/m2 day 1 - 4 , Vindesine 3 mg/m2 day 1 , Cisplatin 40 mg/m2 day 1 - 4 ) and N2 ( Vincristine 1.5 mg/m2 day 1 + 8 , Dacarbazine 200 mg/m2 day 1 - 5 , Ifosfamide 1500 mg/ m2 day 1 - 5 , Doxorubicin 30 mg/m2 day 6 + 7 ) in alternating order .	[{'class': 'POS', 'spans': ['Etoposide', 'Cisplatin', 'Vindesine'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [2, 3, 4, 5], 'is_context_needed': True}]
Mycophenolate mofetil , the prodrug of mycophenolic acid , is widely used for maintenance immunosuppressive therapy in renal transplant recipients .	[]
Efficacy and safety of tacrolimus and low-dose prednisone in Chinese children with steroid-resistant nephrotic syndrome .	[{'class': 'POS', 'spans': ['tacrolimus', 'prednisone'], 'is_context_needed': True}]
Vandetanib inhibited hENT1 , hENT2 , hCNT1 , hCNT2 , and hCNT3 , whereas erlotinib inhibited hENT1 and hCNT3 and gefitinib inhibited hENT1 and hCNT1 .	[]
Genistein reduced Bcl-2 phosphorylation triggered by paclitaxel and vincristine without changing Bax protein expression .	[{'class': 'POS', 'spans': ['Genistein', 'paclitaxel'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}]
Combinations of antibiotics with gentamicin or rifampin in vitro did not significantly alter the killing rate but prevented emergence of subpopulations resistant to the latter .	[]
This Nordic multicenter phase II study evaluated the efficacy and safety of oxaliplatin combined with the Nordic bolus schedule of fluorouracil ( FU ) and folinic acid ( FA ) as first-line treatment in metastatic colorectal cancer .	[{'class': 'POS', 'spans': ['oxaliplatin', 'fluorouracil', 'folinic acid'], 'is_context_needed': True}]
In xenograft studies , the combination of trastuzumab plus letrozole is equally effective in inhibiting growth of MCF-7Ca tumors as letrozole alone .	[{'class': 'POS', 'spans': ['trastuzumab', 'letrozole'], 'is_context_needed': False}]
Reduction of rpS6 expression in Jurkat and HeLa cells attenuated apoptosis induced by TRAIL , but not those by other cell death signals , including tumor necrosis factor-alpha and cycloheximide , etoposide , doxorubicin , tunicamycin and staurosporine .	[]
The patient showed a substantial response to treatment with a combination of antimicrobial therapies consisting of clarithromycin , amikacin , and cefoxitin for 6 months .	[{'class': 'POS', 'spans': ['clarithromycin', 'amikacin', 'cefoxitin'], 'is_context_needed': False}]
The methods have been utilized to evaluate the pharmacokinetics and bioavailability of oral dosage forms containing levodopa and carbidopa .	[{'class': 'COMB', 'spans': ['levodopa', 'carbidopa'], 'is_context_needed': True}]
Increasing the temperature from 60 ° C to 100 ° C decreased the half-life of amoxicillin ( 372 to 50 min ) , ampicillin ( 741 to 26 min ) , cloxacillin ( 367 to 46 min ) , and penicillin G ( 382 to 43 min ) .	[]
Contribution of moxifloxacin or levofloxacin in second-line regimens with or without continuation of pyrazinamide in murine tuberculosis .	[{'class': 'POS', 'spans': ['moxifloxacin', 'pyrazinamide'], 'is_context_needed': True}, {'class': 'POS', 'spans': [1, 2], 'is_context_needed': True}]
High-level resistance to quinolones was frequently observed ( 21 % ) , but resistance to erythromycin ( 3 % ) and tetracycline ( 5 % ) was rare .	[]
The addition of tamoxifen did not worsen the known side effects of gefitinib , or induce additional side effects .	[{'class': 'COMB', 'spans': ['tamoxifen', 'gefitinib'], 'is_context_needed': True}]
A topical combination of 0.25 % finasteride and 3 % minoxidil may be a promising option in the treatment of FPHL with an additional benefit of increasing hair diameter .	[{'class': 'POS', 'spans': ['finasteride', 'minoxidil'], 'is_context_needed': False}]
This report is the first about the long-term use of dasatinib in patients with Ph+ all and mrd elevation but hematologic remission during imatinib chemotherapy .	[]
Acute verapamil toxicity in a patient with chronic toxicity : possible interaction with ceftriaxone and clindamycin .	[{'class': 'NEG', 'spans': ['verapamil', 'ceftriaxone', 'clindamycin'], 'is_context_needed': False}]
Eighty-three patients were treated with rituximab , cyclophosphamide , doxorubicin , vincristine , prednisone ( R-CHOP ) , 7 with rituximab , etoposide , cyclophosphamide , doxorubicin , vincristine , prednisone ( R-EPOCH ) , and 6 with R-CHOP with methotrexate , 3 g/m(2 ) .	[{'class': 'NEG', 'spans': ['rituximab', 'cyclophosphamide', 'doxorubicin', 'vincristine', 'prednisone'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [6, 7, 8, 9, 10, 11], 'is_context_needed': True}, {'class': 'NEG', 'spans': [12, 13], 'is_context_needed': True}]
More active therapies are needed for older and unfit patients with chronic lymphocytic leukemia ( CLL ) who are not eligible for chemoimmunotherapy with fludarabine , cyclophosphamide , and rituximab .	[]
Among them , 18 ( 85.7 % ) patients had disease control with gefitinib and 12 ( 57.1 % ) patients with salvage erlotinib .	[{'class': 'POS', 'spans': ['gefitinib', 'erlotinib'], 'is_context_needed': True}]
In addition to its reproductive function , kisspeptin signalling is also involved in extra-hypothalamic-pituitary-gonadal ( HPG ) axis systems , including oxytocin and arginine vasopressin ( AVP ) secretion .	[]
The combination of volasertib with pemetrexed did not improve efficacy compared with pemetrexed monotherapy .	[{'class': 'NEG', 'spans': ['volasertib', 'pemetrexed'], 'is_context_needed': False}]
A phase I/II study was carried out to determine the maximum tolerated dose of paclitaxel ( Taxol ; Bristol-Myers Squibb Company , Princeton , NJ ) in combination with a fixed dose of carboplatin ( area under the concentration-time curve = 6 by Calvert method ) given on an every-3-week schedule to patients with non-small cell lung cancer ( NSCLC ) .	[{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': True}]
These results suggest that therapy with insulin plus dexamethasone but not therapy with leptin is beneficial for diabetics .	[{'class': 'POS', 'spans': ['dexamethasone', 'insulin'], 'is_context_needed': False}]
After the first course of treatment , a statistically significant improvement ( p = 0.002 ) in the psychological subscale scores was observed after ondansetron compared with metoclopramide .	[]
The rate of grade 3 or 4 neutropenia was higher in the venetoclax-rituximab group than in the bendamustine-rituximab group , but the rates of grade 3 or 4 febrile neutropenia and infections or infestations were lower with venetoclax than with bendamustine .	[]
This study investigated the efficacy and toxicity associated with consolidation chemotherapy using paclitaxel and carboplatin after concurrent chemoradiation ( CCR ) in cervical cancer patients .	[{'class': 'NEG', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': True}]
These secondary leukemias associated with topoisomerase II inhibitors ( most commonly teniposide , etoposide , or doxorubicin ) have distinct clinical and biologic features which have led to the speculation that they are induced by treatment with topoisomerase II inhibitors .	[]
In the intention to treat analysis , 14 patients receiving praziquantel were cured compared with none with mefloquine , one with artesunate ( odds ratio 0·03 , 95 % CI 0·004 - 0·29 ) , one with mefloquine-artesunate ( 0·03 , 0·004 - 0·29 ) , and 19 with tribendimidine ( 1·87 , 0·60 - 5·85 ) .	[]
Cladribine with Granulocyte Colony-Stimulating Factor , Cytarabine , and Aclarubicin Regimen in Refractory/Relapsed Acute Myeloid Leukemia : A Phase II Multicenter Study .	[{'class': 'POS', 'spans': ['Cladribine', 'Granulocyte Colony-Stimulating Factor', 'Cytarabine', 'Aclarubicin'], 'is_context_needed': True}]
In guinea pig trachea and human bronchial smooth muscle , SALM was more potent than isoprenaline ( ISO ) , salbutamol ( SALB ) , and clenbuterol ( CLEN ) .	[]
Combining erlotinib with doxorubicin or docetaxel or SN-38 resulted in additive or even synergistic antiproliferative effects .	[{'class': 'POS', 'spans': ['erlotinib', 'doxorubicin'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 3], 'is_context_needed': False}]
Importantly , the risk of neutropenia 14 days after initiation of treatment with artesunate plus amodiaquine was higher among HIV-infected children than among HIV-uninfected children ( 45 % vs. 6 % ; p < .001 ) .	[]
During this period , blood pressure ( BP ) was monitored weekly , and daily rhythms of melatonin , corticosterone , leptin and testosterone were evaluated at the end of the experiment .	[]
Offspring whose father filled at least one prescription of the following medications in the three months preceding conception were considered exposed : chloroquine , hydroxychloroquine , losartan , azithromycin , naproxen , dexamethasone and prednisone .	[]
The present work is concerned with simultaneous determination of cefepime ( CEF ) and the co-administered drug , levofloxacin ( LEV ) , in spiked human plasma by applying a new approach , Savitzky-Golay differentiation filters , and combined trigonometric Fourier functions to their ratio spectra .	[{'class': 'POS', 'spans': ['cefepime', 'levofloxacin'], 'is_context_needed': False}]
Forthcoming data from phase 3 placebo-controlled trials of everolimus , one focused on monotherapy for pancreatic NET and the other on combination use with octreotide LAR for patients with advanced NET and a history of carcinoid syndrome , will provide insight into its future place in NET therapy .	[{'class': 'COMB', 'spans': ['everolimus', 'octreotide'], 'is_context_needed': True}]
The effects of prednisone and azathioprine on circulating immunoglobulin levels and lymphocyte subpopulations in normal dogs .	[{'class': 'NEG', 'spans': ['prednisone', 'azathioprine'], 'is_context_needed': True}]
The analytical range for dihydroartemisinin , dihydroartemisinin-glucuronide and artesunate was 10 - 1000 ng/ml and for artemether 90 - 3000 ng/ml with a lower limit of quantification of 10 and 90 ng/ml , respectively .	[{'class': 'COMB', 'spans': ['dihydroartemisinin', 'dihydroartemisinin-glucuronide', 'artesunate'], 'is_context_needed': True}]
Amphotericin B MICs were reduced upon combination with rifabutin from a mean of 0.65 microg/ml to a mean of 0.16 microg/ml against Aspergillus , and from a mean of 0.97 microg/ml to a mean of 0.39 microLg/ml against Fusarium ( P < 0.000001 for both ) .	[{'class': 'POS', 'spans': ['Amphotericin', 'rifabutin'], 'is_context_needed': True}]

This document attempts to provide reasonable guidance for the use of antimicrobials which have uncertain benefit but may increase risk of QT interval prolongation and ventricular proarrhythmia , notably , chloroquine , hydroxychloroquine , azithromycin , and lopinavir/ritonavir .

[]

Phase II study of weekly paclitaxel and sorafenib as second/third-line therapy in patients with adrenocortical carcinoma .

[{'class': 'NEG', 'spans': ['paclitaxel', 'sorafenib'], 'is_context_needed': True}]

This study indicates that cyclophosphamide , doxorubicin , and methotrexate are , at best , marginally active as single agents , and new drugs with more efficacy are needed before combination chemotherapy can be expected to result in any meaningful prolongation of survival in non-small cell lung cancer .

[{'class': 'POS', 'spans': ['cyclophosphamide', 'doxorubicin', 'methotrexate'], 'is_context_needed': True}]

The combined treatment of curcumin and docetaxel inhibited the proliferation and induced apoptosis significantly higher than the curcumin and docetaxel-treated group alone .

[{'class': 'POS', 'spans': ['curcumin', 'docetaxel'], 'is_context_needed': False}]

Previously , a study of ours showed that the combination of dabrafenib and trametinib improves progression-free survival compared with dabrafenib and placebo in patients with BRAF Val600Lys/Glu mutation-positive metastatic melanoma .

[{'class': 'POS', 'spans': ['dabrafenib', 'trametinib'], 'is_context_needed': False}]

compared to those for rats treated with trovafloxacin or clindamycin plus gentamicin

[{'class': 'NEG', 'spans': ['clindamycin', 'gentamicin'], 'is_context_needed': True}]

We suggest topoisomerase II inhibition by Aroclor 1254 , trovafloxacin , doxorubicin , and etoposide to be responsible for significant co-localization of regulated genes through the inability of the stabilized enzyme complexes to religate DNA .

[]

All but one received two induction courses of the 3 day-AVI ( doxorubicin 50 mg/m(2 ) day 1 , etoposide 120 mg/m(2 ) day 1 , 2 , 3 , ifosfamide 2000 mg/m(2 ) day 1 , 2 ) regimen .

[{'class': 'POS', 'spans': ['doxorubicin', 'etoposide', 'ifosfamide'], 'is_context_needed': True}]

Although anti-HER2 ( trastuzumab ) and anti-VEGFR ( ramucirumab ) may yield survival benefit , anti-EGFR and anti-HGFR therapies have failed to improve outcomes .

[]

In the phase I trial , 19 patients received bolus doxorubicin ( 50 mg/m2 ) followed after a 16-hour interval by paclitaxel ( given at dose levels ranging from 130 to 250 mg/m2 ) by 3-hour infusion every 3 weeks , for a maximum of eight cycles .

[{'class': 'POS', 'spans': ['doxorubicin', 'paclitaxel'], 'is_context_needed': True}]

New monoclonal antibodies ( ofatumumab ) , second-generation proteasome inhibitors ( carfilzomib ) , mammalian target of rapamycin inhibitors , and Bruton 's tyrosine kinase inhibitors are promising and may expand future treatment options .

[]

Exposure of LLC-PK1 cells to hydrogen peroxide ( 2.5 mM ) resulted in a significant increase in the bleomycin-detectable iron ( iron capable of catalyzing free radical reactions ) content that was prevented by cimetidine , but not ranitidine .

[{'class': 'POS', 'spans': ['hydrogen peroxide', 'cimetidine'], 'is_context_needed': False}, {'class': 'NEG', 'spans': [0, 2], 'is_context_needed': False}]

Patients who did or did not respond to previous DIMARD therapy either on i.m . gold , D-Penicillamine or Chloroquine , did usually well when treated with Auranofin , even if severe side effects leading to withdrawal had occurred on previous therapy .

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Patients were randomly assigned 1:1 centrally to either the docetaxel , prednisone , and custirsen combination or docetaxel and prednisone alone .

[{'class': 'POS', 'spans': ['docetaxel', 'prednisone', 'custirsen'], 'is_context_needed': True}]

[ Carboplatin and etoposide combination for the treatment of recurrent epithelial ovarian cancer ] .

[{'class': 'POS', 'spans': ['Carboplatin', 'etoposide'], 'is_context_needed': True}]

One-hour paclitaxel plus carboplatin in the treatment of advanced non-small cell lung cancer : results of a multicentre , phase II trial .

[{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': True}]

Preliminary data combining trastuzumab with the antiangiogenic antibody bevacizumab is encouraging ; this combination will be tested in both early stage and late stage disease .

[{'class': 'POS', 'spans': ['trastuzumab', 'bevacizumab'], 'is_context_needed': False}]

The immuno-oncology-based combinations with different types of immune checkpoint inhibitors ( PD-1/PD-L1 and CTLA-4 inhibitors such as nivolumab , pembrolizumab , atezolizumab , durvalumab , ipilimumab , tremelimumab ) , or the association of immune checkpoint inhibitors plus anti-angiogenic agents ( bevacizumab , lenvatinib , cabozantinib ) , have led to a breakthrough in the treatment of hepatocellular carcinoma .

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A decrease in VEGF-A expression in the tumor node and salivary gland was found after monotherapy with melatonin and cyclophosphamide and , especially , after combined treatment , which proves maximum therapeutic efficiency of combined administration of chemical agents with various mechanisms of action .

[{'class': 'POS', 'spans': ['melatonin', 'cyclophosphamide'], 'is_context_needed': False}]

The combination of rituximab , bendamustine , and cytarabine ( R-BAC ) was highly active in a pilot trial of mantle cell lymphoma , but its use was restricted by high haematological toxicity .

[{'class': 'POS', 'spans': ['rituximab', 'bendamustine', 'cytarabine'], 'is_context_needed': False}]

Despite treatment with PH specific therapy ( sildenafil , ambrisentan , and epoprostenol ) , her condition worsened rapidly with acute right heart failure ( RHF ) .

[{'class': 'COMB', 'spans': ['sildenafil', 'ambrisentan', 'epoprostenol'], 'is_context_needed': True}]

Data from the present study show the feasibility and tolerability of combination ixabepilone plus carboplatin , with ixabepilone administered on day 1 or on days 1 and 8 on a 21-day cycle .

[{'class': 'COMB', 'spans': ['ixabepilone', 'carboplatin'], 'is_context_needed': True}]

Compared to other glucose lowering agents except metformin , gliclazide was slightly more effective ( -0.13 % ( 95%CI : -0.25 , -0.02 , I(2 ) 55 % ) ) .

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Thirteen stage III B and 13 stage IV patients received intermediate doses of ifosfamide ( 1000 mg/m2 ) , carboplatin ( 120 mg/m2 ) and etoposide ( 120 mg/m2 ) given intravenously on day 1 to 3 every 4 weeks .

[{'class': 'POS', 'spans': ['ifosfamide', 'carboplatin', 'etoposide'], 'is_context_needed': True}]

This study compared immediate ( overnight ) and progressive switching to oxcarbazepine monotherapy in patients with partial seizures unsatisfactorily treated with carbamazepine monotherapy .

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In conclusion , prasugrel can be used successfully in most patients with a history of clopidogrel hypersensitivity .

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Fresh , clinical P. falciparum isolates were also tested in the presence of several drugs , including chloroquine , mefloquine , quinine , halofantrine , atovaquone and qinghaosu derivatives .

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The null hypothesis was there is no difference with respect to pain scores between ketorolac and iliac crest bupivacaine infusion as analgesic adjuncts to intravenous opioids .

[{'class': 'POS', 'spans': ['ketorolac', 'bupivacaine'], 'is_context_needed': True}]

Etoposide in combination with low-dose CAG ( cytarabine , aclarubicin , G-CSF ) for the treatment of relapsed or refractory acute myeloid leukemia : a multicenter , randomized control trial in southwest China .

[{'class': 'POS', 'spans': ['Etoposide', 'cytarabine', 'aclarubicin', 'G-CSF'], 'is_context_needed': True}]

were randomized in an open-label , crossover fashion to treatment A ( dolasetron 100 mg on day 1 ) and treatment B ( dolasetron 100 mg plus aprepitant 125 mg on day 1 , aprepitant 80 mg on days 2 - 3 ) .

[{'class': 'POS', 'spans': ['dolasetron', 'aprepitant'], 'is_context_needed': True}]

The regimen of gemcitabine combined with ifosfamide and anthracycline is feasible , tolerable and effective in patients with recurrent platinum resistant/refractory epithelial ovarian cancer .

[{'class': 'POS', 'spans': ['gemcitabine', 'ifosfamide', 'anthracycline'], 'is_context_needed': False}]

Second-line treatments consisted of cetuximab plus irinotecan for arm A , and oxaliplatin plus either 5-fluorouracil ( FOLFOX ) or capecitabine ( CapeOX ) for the control arms .

[{'class': 'POS', 'spans': ['cetuximab', 'irinotecan'], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 4], 'is_context_needed': True}]

In the UT-EC-1 cell line the growth inhibition was 72 % with paclitaxel , 54 % with carboplatin and 73 % with the combination of these compounds .

[{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': True}]

Several lines of evidence implicate serotonin ( 5-HT ) as the mediator of this enhancement : ( 1 ) Tranyclypromine-enhanced nicotine reinforcement was blocked by the 5-HT₂ receptor antagonists , ritanserin and ketanserin ; ( 2 ) parachloroamphetamine ( PCA ) , a 5-HT releaser , also enhanced nicotine self-administration in animals in which MAO activity was inhibited ; ( 3 ) pretreatment with tranylcypromine increased PCA-induced 5-HT overflow in the nucleus accumbens .

[{'class': 'COMB', 'spans': ['nicotine', 'ketanserin'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [2, 4], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 5], 'is_context_needed': True}]

Measurement and simulation results obtained in the batch experiments , spiked with the diclofenac and carbamazepine content of preclarified municipal wastewater shows comparably high biotransformation rates in the presence of growth substrates .

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Ursodeoxycholic acid is conjugated with taurine to promote secretin-stimulated biliary hydrocholeresis in the normal rat .

[{'class': 'POS', 'spans': ['Ursodeoxycholic acid', 'taurine'], 'is_context_needed': True}]

This study assessed the efficacy and safety of telaprevir in combination with peginterferon-α-2b ( PEG IFN ) and ribavirin ( RBV ) , for Japanese difficult-to-treat patients with hepatitis C virus ( HCV ) genotype 2 who had not achieved sustained virological response ( SVR ) during prior treatment .

[{'class': 'POS', 'spans': ['telaprevir', 'peginterferon-α-2b'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}]

The binding affinity profile of 5-HT1D binding sites [ 5-CT > 5-HT > d-LSD > 5-MeOT > sumatriptan > RU 24,969 > metergoline > tryptamine = rauwolscine = methylsergide > yohimbine = methiothepin > TFMPP = 8-OH-DPAT > 2-methyl-5-HT > mCPP = quipazine = CP 93,129 > ketanserin > (-)-propranolol = haloperidol = ipsapirone ] compares well to that reported for 5-HT1D receptor sites in human caudate and cortex ( correlation coefficient : 0.99 and 0.98 ) .

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The MX2 cells are cross-resistant to etoposide , teniposide , bisantrene , dactinomycin , 4'-(9-acridinylamino)methanesulfon-m-anisidide , and the anthracyclines daunorubicin and doxorubicin but retain sensitivity to the Vinca alkaloids melphalan and mitomycin C. In addition , the MX2 cells display slight collateral sensitivity to bleomycin .

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Combination of a betalactam antibiotic ( ampicillin or azlocillin ) or polymyxin B with rifampicin were studied with their administration in succession at various intervals in an experimental model of plague infection of albino mice .

[{'class': 'POS', 'spans': ['ampicillin', 'rifampicin'], 'is_context_needed': True}, {'class': 'POS', 'spans': [1, 3], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': True}]

Between August 1993 and September 1994 , 6010 patients were randomized to receive either reteplase ( n = 3004 ) or streptokinase ( n = 3006 ) .

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In patients coinfected and treated for both HIV-1 and hepatitis C virus ( HCV ) , administration of ribavirin ( RBV ) may result in altered intracellular drug levels of nucleoside reverse transcriptase inhibitors through inhibition of inosine 5'-monophosphate dehydrogenase .

[]

Previous treatments with rituximab and with rituximab plus high dose glucocorticoids , as well as with cyclophosphamide , azathioprine , plasma exchange , hyperbaric therapy , VAC therapy , prostacyclin , mycophenolate mofetil and surgery , had previously failed .

[{'class': 'NEG', 'spans': ['rituximab', 'glucocorticoids'], 'is_context_needed': False}, {'class': 'NEG', 'spans': [1, 2], 'is_context_needed': False}, {'class': 'NEG', 'spans': [1, 3], 'is_context_needed': False}]

The decision to test a triple combination has led to the development of Fansimef , a fixed combination with tablets containing 250 mg mefloquine , 500 mg sulfadoxine and 25 mg pyrimethamine .

[{'class': 'POS', 'spans': ['mefloquine', 'sulfadoxine', 'pyrimethamine'], 'is_context_needed': True}]

The aim of this study was to evaluate three active agents , bleomycin ( BLM ) , epirubicin and carboplatin in a new combination ( BECA ) in terms of feasibility , activity and toxicity in patients with recurrent and metastatic squamous cell carcinoma of the head and neck .

[{'class': 'POS', 'spans': ['bleomycin', 'epirubicin', 'carboplatin'], 'is_context_needed': True}]

Survival Benefits of Second-line Axitinib Versus Everolimus After First Line Sunitinib Treatment in Metastatic Renal Cell Carcinoma .

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A phase II trial of cytarabine , cisplatin , and etoposide was conducted in 38 patients with refractory stage III and IV non-Hodgkin 's lymphoma .

[{'class': 'COMB', 'spans': ['cytarabine', 'cisplatin', 'etoposide'], 'is_context_needed': True}]

The combination of camrelizumab plus gemcitabine and cisplatin has a manageable toxicity profile and promising preliminary antitumour activity for this disease in treatment-naive patients .

[{'class': 'POS', 'spans': ['camrelizumab', 'gemcitabine', 'cisplatin'], 'is_context_needed': False}]

His infection failed to respond to combinations of surgery , fluconazole and itraconazole .

[{'class': 'NEG', 'spans': ['fluconazole', 'itraconazole'], 'is_context_needed': True}]

The protective effect of tianeptine against PTZ seizures was mitigated when tianeptine was administered with naloxone .

[{'class': 'COMB', 'spans': ['tianeptine', 'naloxone'], 'is_context_needed': True}]

Twenty-one trials involving 3646 patients were included : 11 trials using beta-blockers ( 6 drugs ; 866 patients ) , 6 clonidine or mivazerol ( 614 patients ) , 3 diltiazem or verapamil ( 121 patients ) , and 1 nitroglycerin ( 45 patients ) .

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The sensitivity of human neuroblastoma-derived cell lines , cell line-derived , and patient-derived xenograft ( PDX ) models with varying ALK statuses to crizotinib combined with topotecan and cyclophosphamide ( topo/cyclo ) was examined .

[{'class': 'POS', 'spans': ['crizotinib', 'topotecan', 'cyclophosphamide'], 'is_context_needed': True}]

Patients were randomised to either receive additional tretinoin ( 45mg/m(2)/day ) for 12 weeks ( arm A ) , or peg-interferon and ribavirin alone ( arm B ) .

[{'class': 'COMB', 'spans': ['ribavirin', 'peg-interferon'], 'is_context_needed': True}]

This study sought to determine the efficacy and toxicity of weekly paclitaxel and carboplatin in CUP .

[{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': True}]

To investigate the presence of extended spectrum and metallo β-lactamases ( MBLs ) in Pseudomonas aeruginosa isolates which are resistant to imipenem and ceftazidime that were isolated in a hospital in Mexico .

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The patient achieved complete remission after two cycles of chemotherapy of daunorubicin , cytarabine and etoposide .

[{'class': 'POS', 'spans': ['daunorubicin', 'cytarabine', 'etoposide'], 'is_context_needed': False}]

We included 10 pharmacological ( modafinil , intravenous immunoglobulin ( IVIg ) , pyridostigmine , lamotrigine , amantadine , prednisone ) and three non-pharmacological ( muscle strengthening , rehabilitation in a warm climate ( that is temperature ± 25 ° C , dry and sunny ) and a cold climate ( that is temperature ± 0 ° C , rainy or snowy ) , static magnetic fields ) studies with a total of 675 participants with PPS in this review .

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Protection against CsA-induced PST cell death was afforded by reduction in extracellular calcium levels in the media or addition of the calcium entry antagonists : verapamil , nifedipine or diltiazem .

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This synergy was abrogated through siRNA knockdown of IkB. The synergistic effect of combining selinexor and bortezomib in vitro provides rationale for further investigation of this combination treatment for patients with high-risk neuroblastoma .

[{'class': 'POS', 'spans': ['selinexor', 'bortezomib'], 'is_context_needed': False}]

Therapy included 4 or 8 intensive therapy elements N1 ( Etoposide 125 mg/m2 day 1 - 4 , Vindesine 3 mg/m2 day 1 , Cisplatin 40 mg/m2 day 1 - 4 ) and N2 ( Vincristine 1.5 mg/m2 day 1 + 8 , Dacarbazine 200 mg/m2 day 1 - 5 , Ifosfamide 1500 mg/ m2 day 1 - 5 , Doxorubicin 30 mg/m2 day 6 + 7 ) in alternating order .

[{'class': 'POS', 'spans': ['Etoposide', 'Cisplatin', 'Vindesine'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [2, 3, 4, 5], 'is_context_needed': True}]

Mycophenolate mofetil , the prodrug of mycophenolic acid , is widely used for maintenance immunosuppressive therapy in renal transplant recipients .

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Efficacy and safety of tacrolimus and low-dose prednisone in Chinese children with steroid-resistant nephrotic syndrome .

[{'class': 'POS', 'spans': ['tacrolimus', 'prednisone'], 'is_context_needed': True}]

Vandetanib inhibited hENT1 , hENT2 , hCNT1 , hCNT2 , and hCNT3 , whereas erlotinib inhibited hENT1 and hCNT3 and gefitinib inhibited hENT1 and hCNT1 .

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Genistein reduced Bcl-2 phosphorylation triggered by paclitaxel and vincristine without changing Bax protein expression .

[{'class': 'POS', 'spans': ['Genistein', 'paclitaxel'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}]

Combinations of antibiotics with gentamicin or rifampin in vitro did not significantly alter the killing rate but prevented emergence of subpopulations resistant to the latter .

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This Nordic multicenter phase II study evaluated the efficacy and safety of oxaliplatin combined with the Nordic bolus schedule of fluorouracil ( FU ) and folinic acid ( FA ) as first-line treatment in metastatic colorectal cancer .

[{'class': 'POS', 'spans': ['oxaliplatin', 'fluorouracil', 'folinic acid'], 'is_context_needed': True}]

In xenograft studies , the combination of trastuzumab plus letrozole is equally effective in inhibiting growth of MCF-7Ca tumors as letrozole alone .

[{'class': 'POS', 'spans': ['trastuzumab', 'letrozole'], 'is_context_needed': False}]

Reduction of rpS6 expression in Jurkat and HeLa cells attenuated apoptosis induced by TRAIL , but not those by other cell death signals , including tumor necrosis factor-alpha and cycloheximide , etoposide , doxorubicin , tunicamycin and staurosporine .

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The patient showed a substantial response to treatment with a combination of antimicrobial therapies consisting of clarithromycin , amikacin , and cefoxitin for 6 months .

[{'class': 'POS', 'spans': ['clarithromycin', 'amikacin', 'cefoxitin'], 'is_context_needed': False}]

The methods have been utilized to evaluate the pharmacokinetics and bioavailability of oral dosage forms containing levodopa and carbidopa .

[{'class': 'COMB', 'spans': ['levodopa', 'carbidopa'], 'is_context_needed': True}]

Increasing the temperature from 60 ° C to 100 ° C decreased the half-life of amoxicillin ( 372 to 50 min ) , ampicillin ( 741 to 26 min ) , cloxacillin ( 367 to 46 min ) , and penicillin G ( 382 to 43 min ) .

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Contribution of moxifloxacin or levofloxacin in second-line regimens with or without continuation of pyrazinamide in murine tuberculosis .

[{'class': 'POS', 'spans': ['moxifloxacin', 'pyrazinamide'], 'is_context_needed': True}, {'class': 'POS', 'spans': [1, 2], 'is_context_needed': True}]

High-level resistance to quinolones was frequently observed ( 21 % ) , but resistance to erythromycin ( 3 % ) and tetracycline ( 5 % ) was rare .

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The addition of tamoxifen did not worsen the known side effects of gefitinib , or induce additional side effects .

[{'class': 'COMB', 'spans': ['tamoxifen', 'gefitinib'], 'is_context_needed': True}]

A topical combination of 0.25 % finasteride and 3 % minoxidil may be a promising option in the treatment of FPHL with an additional benefit of increasing hair diameter .

[{'class': 'POS', 'spans': ['finasteride', 'minoxidil'], 'is_context_needed': False}]

This report is the first about the long-term use of dasatinib in patients with Ph+ all and mrd elevation but hematologic remission during imatinib chemotherapy .

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Acute verapamil toxicity in a patient with chronic toxicity : possible interaction with ceftriaxone and clindamycin .

[{'class': 'NEG', 'spans': ['verapamil', 'ceftriaxone', 'clindamycin'], 'is_context_needed': False}]

Eighty-three patients were treated with rituximab , cyclophosphamide , doxorubicin , vincristine , prednisone ( R-CHOP ) , 7 with rituximab , etoposide , cyclophosphamide , doxorubicin , vincristine , prednisone ( R-EPOCH ) , and 6 with R-CHOP with methotrexate , 3 g/m(2 ) .

[{'class': 'NEG', 'spans': ['rituximab', 'cyclophosphamide', 'doxorubicin', 'vincristine', 'prednisone'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [6, 7, 8, 9, 10, 11], 'is_context_needed': True}, {'class': 'NEG', 'spans': [12, 13], 'is_context_needed': True}]

More active therapies are needed for older and unfit patients with chronic lymphocytic leukemia ( CLL ) who are not eligible for chemoimmunotherapy with fludarabine , cyclophosphamide , and rituximab .

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Among them , 18 ( 85.7 % ) patients had disease control with gefitinib and 12 ( 57.1 % ) patients with salvage erlotinib .

[{'class': 'POS', 'spans': ['gefitinib', 'erlotinib'], 'is_context_needed': True}]

In addition to its reproductive function , kisspeptin signalling is also involved in extra-hypothalamic-pituitary-gonadal ( HPG ) axis systems , including oxytocin and arginine vasopressin ( AVP ) secretion .

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The combination of volasertib with pemetrexed did not improve efficacy compared with pemetrexed monotherapy .

[{'class': 'NEG', 'spans': ['volasertib', 'pemetrexed'], 'is_context_needed': False}]

A phase I/II study was carried out to determine the maximum tolerated dose of paclitaxel ( Taxol ; Bristol-Myers Squibb Company , Princeton , NJ ) in combination with a fixed dose of carboplatin ( area under the concentration-time curve = 6 by Calvert method ) given on an every-3-week schedule to patients with non-small cell lung cancer ( NSCLC ) .

[{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': True}]

These results suggest that therapy with insulin plus dexamethasone but not therapy with leptin is beneficial for diabetics .

[{'class': 'POS', 'spans': ['dexamethasone', 'insulin'], 'is_context_needed': False}]

After the first course of treatment , a statistically significant improvement ( p = 0.002 ) in the psychological subscale scores was observed after ondansetron compared with metoclopramide .

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The rate of grade 3 or 4 neutropenia was higher in the venetoclax-rituximab group than in the bendamustine-rituximab group , but the rates of grade 3 or 4 febrile neutropenia and infections or infestations were lower with venetoclax than with bendamustine .

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This study investigated the efficacy and toxicity associated with consolidation chemotherapy using paclitaxel and carboplatin after concurrent chemoradiation ( CCR ) in cervical cancer patients .

[{'class': 'NEG', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': True}]

These secondary leukemias associated with topoisomerase II inhibitors ( most commonly teniposide , etoposide , or doxorubicin ) have distinct clinical and biologic features which have led to the speculation that they are induced by treatment with topoisomerase II inhibitors .

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In the intention to treat analysis , 14 patients receiving praziquantel were cured compared with none with mefloquine , one with artesunate ( odds ratio 0·03 , 95 % CI 0·004 - 0·29 ) , one with mefloquine-artesunate ( 0·03 , 0·004 - 0·29 ) , and 19 with tribendimidine ( 1·87 , 0·60 - 5·85 ) .

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Cladribine with Granulocyte Colony-Stimulating Factor , Cytarabine , and Aclarubicin Regimen in Refractory/Relapsed Acute Myeloid Leukemia : A Phase II Multicenter Study .

[{'class': 'POS', 'spans': ['Cladribine', 'Granulocyte Colony-Stimulating Factor', 'Cytarabine', 'Aclarubicin'], 'is_context_needed': True}]

In guinea pig trachea and human bronchial smooth muscle , SALM was more potent than isoprenaline ( ISO ) , salbutamol ( SALB ) , and clenbuterol ( CLEN ) .

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Combining erlotinib with doxorubicin or docetaxel or SN-38 resulted in additive or even synergistic antiproliferative effects .

[{'class': 'POS', 'spans': ['erlotinib', 'doxorubicin'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 3], 'is_context_needed': False}]

Importantly , the risk of neutropenia 14 days after initiation of treatment with artesunate plus amodiaquine was higher among HIV-infected children than among HIV-uninfected children ( 45 % vs. 6 % ; p < .001 ) .

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During this period , blood pressure ( BP ) was monitored weekly , and daily rhythms of melatonin , corticosterone , leptin and testosterone were evaluated at the end of the experiment .

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Offspring whose father filled at least one prescription of the following medications in the three months preceding conception were considered exposed : chloroquine , hydroxychloroquine , losartan , azithromycin , naproxen , dexamethasone and prednisone .

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The present work is concerned with simultaneous determination of cefepime ( CEF ) and the co-administered drug , levofloxacin ( LEV ) , in spiked human plasma by applying a new approach , Savitzky-Golay differentiation filters , and combined trigonometric Fourier functions to their ratio spectra .

[{'class': 'POS', 'spans': ['cefepime', 'levofloxacin'], 'is_context_needed': False}]

Forthcoming data from phase 3 placebo-controlled trials of everolimus , one focused on monotherapy for pancreatic NET and the other on combination use with octreotide LAR for patients with advanced NET and a history of carcinoid syndrome , will provide insight into its future place in NET therapy .

[{'class': 'COMB', 'spans': ['everolimus', 'octreotide'], 'is_context_needed': True}]

The effects of prednisone and azathioprine on circulating immunoglobulin levels and lymphocyte subpopulations in normal dogs .

[{'class': 'NEG', 'spans': ['prednisone', 'azathioprine'], 'is_context_needed': True}]

The analytical range for dihydroartemisinin , dihydroartemisinin-glucuronide and artesunate was 10 - 1000 ng/ml and for artemether 90 - 3000 ng/ml with a lower limit of quantification of 10 and 90 ng/ml , respectively .

[{'class': 'COMB', 'spans': ['dihydroartemisinin', 'dihydroartemisinin-glucuronide', 'artesunate'], 'is_context_needed': True}]

Amphotericin B MICs were reduced upon combination with rifabutin from a mean of 0.65 microg/ml to a mean of 0.16 microg/ml against Aspergillus , and from a mean of 0.97 microg/ml to a mean of 0.39 microLg/ml against Fusarium ( P < 0.000001 for both ) .

[{'class': 'POS', 'spans': ['Amphotericin', 'rifabutin'], 'is_context_needed': True}]