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10,010,603 | With the development of more effective combination chemotherapy and radiation, the role of surgical resection in the management of gastric lymphoma is reappraised. A retrospective review of 32 patients with gastric lymphoma, diagnosed and treated during the period between 1966-1979, is presented in an attempt to evalua... | [
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10,010,604 | Medical adrenalectomy in patients with advanced breast cancer. | [
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10,010,605 | Medical adrenalectomy, consisting of aminoglutethimide plus either dexamethasone or hydrocortisone, was administered to 53 women with advanced breast cancer. Sixteen (30%) patients had an objective response, five patients had stabilization of disease, 26 patients demonstrated progression of disease, two patients did no... | [
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10,010,606 | Mechanisms of immunosuppression in tumor-bearing mice: a multifactorial analysis. | [
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10,010,607 | Neoplastic growth results not only from the inherent proliferative potential of the neoplasm, but also from the neoplasm's ability to survive within a host whose immune responses may be activated to destroy it. It has been proposed that several mechanisms enable a neoplasm to outgrow the host. The present work describe... | [
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10,010,608 | Immunotherapeutic effects of tumor-specific transplantation antigens released by 1-butanol. | [
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10,010,609 | Active immunotherapy with materials extracted from a murine methylcholanthrene-induced sarcoma using single phase solutions of 2.5% 1-butanol evoked host resistance against supralethal burdens of neoplastic cells deposited subcutaneously or delivered hematogenously. After curative resection of progressing 1 cm tumors, ... | [
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10,010,610 | Effects of dopamine agonists and antagonists on murine melanoma: correlation with dopamine binding activity. | [
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10,010,611 | The biosynthetic pathway melanin is present in many melanomas. Previous investigations have suggested that pharmacologic levels of intermediates in this pathway (L-dopa, dopamine, and their analogues) may inhibit macromolecular synthesis in some tissue culture melanoma cell lines and prolong survival in tumor-bearing m... | [
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10,010,612 | Fecal steroid metabolites and breast cancer risk. | [
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10,010,613 | Women with breast cancer (n = 78) had a higher excretion of total fecal steroids in mg/gm of dry weight (56 + 37) compared to controls (45 + 29; n = 71) (P = 0.03). Increases in both total neutral steroids and total bile acids in cases contributed to this significant difference. Lean women (Quetelet's index less than 3... | [
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10,010,614 | Ex vivo perfusion of human colon with monoclonal anticolorectal cancer antibodies. | [
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10,010,615 | The binding of mouse hybridoma monoclonal antibodies directed against human colon carcinomas was studied using an ex vivo perfusion model of a freshly resected human colon segment containing a carcinoma. Tumor and the surrounding normal bowel is exposed to the putative tumor antigen through an intact vascular system wi... | [
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10,010,616 | Thermochemotherapy for melanoma metastases in liver. | [
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10,010,617 | Metastatic melanoma in the liver has carried an extremely poor prognosis regardless of therapy. Because transient responses (1/6 disease regressions and 2/6 disease stabilizations for four months) in selected patients treated with intraarterial (IA) DTIC infusion were encouraging and because localized hyperthermia may ... | [
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10,010,618 | Primary gastrointestinal lymphoma: a 30-year review. | [
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10,010,619 | The authors reviewed all cases of non-Hodgkin's lymphoma primarily involving the gastrointestinal tract treated at Memorial Hospital during the period from 1949-1978. Complete clinical records were available in 104 cases. Slides of original pathology specimens were available in 81 cases. Tumors were classified by Rappa... | [
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10,010,620 | Major chest wall reconstruction after chest wall irradiation. | [
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10,010,621 | In the last year, 12 patients have undergone extensive chest wall resection. Eight patients had recurrent cancer after prior resection and irradiation with an average defect of 160 square centimeters, usually including ribs and a portion of the sternum; four had radionecrosis of soft tissue and/or bone. Methods of reco... | [
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10,010,622 | A new method for treating carcinomatous biliary obstruction with intracatheter radium. | [
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10,010,623 | We describe a new method for relieving biliary obstruction due to malignant solid tumors. The method consists of placement of radium needles in a Ring biliary drainage catheter for three days. After removing the radium needles, the catheter is left in place to allow for repair of irradiated tissues, then it is removed.... | [
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10,010,624 | Phase II study of high-dose tamoxifen (NSC-180973) in patients with disseminated malignant melanoma. | [
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10,010,625 | Seventeen patients with disseminated malignant melanoma received a daily oral regimen of tamoxifen, 100 mg/m2. All patients had prior chemotherapy and predominantly visceral involvement. None of the patients had an objective regression and most (71%) had progressive disease at the time of first reassessment. Moderate t... | [
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10,010,626 | Failure of short-course multiple drug chemotherapy to benefit patients with recurrent or metastatic head and neck cancer. | [
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10,010,627 | Fifty-seven patients with advanced cancer (52 with squamous cell carcinoma of the head and neck) were treated with short-course, multiple drug chemotherapy using schedules that were similar to those proposed by Price et al. Chemotherapy consisted of vincristine, methotrexate and folinic acid rescue, bleomycin, and FU, ... | [
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10,010,628 | Considerations for the use of testosterone with systemic chemotherapy in prostatic cancer. | [
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10,010,629 | Among 52 patients with metastatic adenocarcinoma of the prostate who were treated with exogenous testosterone, 45 (87%) experienced unfavorable subjective and/or objective responses. These unfavorable responses were elicited more frequently and after shorter treatment periods in patients in symptomatic relapse followin... | [
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10,010,630 | Pilot studies using melanoma tumor-associated antigens (TAA) in specific-active immunochemotherapy of malignant melanoma. | [
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10,010,631 | Highly purified melanoma TAA which induce melanoma-related cellmediated immune responses have been further characterized using hyperimmune TAA antisera after affinity chromatography for double immunodiffusion-immunoelectrophoresis and indirect immunofluorescence studies. An additional study of antigenic modulation was ... | [
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10,010,632 | Numerical and structural chromosome aberrations in cultured lymphocytes and cutaneous fibroblasts of patients with multiple adenomas of the colorectum. | [
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10,010,633 | Excessive random loss and gain of simple chromosomes at the diploid and tetraploid levels, and numerous chromosomal aberrations, have been observed in lymphocytes and fibroblasts, cultured from Gardner syndrome and familial polyposis coli patients and children at risk for multiple adenomas. This increase in numerical a... | [
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10,010,634 | Complex cerebral tumor with evidence of neuronal, glial and Schwann cell differentiation: a histologic, immunocytochemical and ultrastructural study. | [
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10,010,635 | An unusual cerebral tumor is reported in a ten-month-old boy. The tumor was large (10 cm x 6 cm), firm and included several cysts. Light and electron microscopy showed a striking cellular pleomorphism. Typical neurosecretory ganglion cells were observed, always surrounded by Schwann cells. Amyelinic neurites, clusters ... | [
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10,010,636 | Endobronchial metastatic plasmacytoma. | [
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10,010,637 | Plasmacytomas are rare tumors and an endobronchial presentation has not been previously described. A 64-year-old white woman with metastatic involvement by plasmacytoma is presented. A review of the literature indicates the difficulty in distinguishing this lesion from benign plasma cell tumors of the lung and the prol... | [
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10,010,638 | Acquired extrinsic pulmonic stenosis caused by mediastinal tumors. | [
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10,010,639 | Clinically detectable pulmonic stenosis resulting from compression of the pulmonary artery or right ventricular outflow tract by mediastinal tumors is uncommon. This report describes the occurrence of pulmonic stenosis secondary to a mediastinal tumor in a patient with Hodgkin's disease and in two patients with non-Hod... | [
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0.06888410449028015,
0.040582623332738876,
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10,010,640 | Familial juvenile colonic polyposis with associated colon cancer. | [
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0.00708... |
10,010,641 | A mother and son were found to have multiple juvenile polyps of the colon; later a metastatic adenocarcinoma of the large bowel developed in the mother. In both patients, histologic examination of the polyps did not reveal adenomas, but some of the juvenile polyps contained adenomatous-like elements. Because of the mot... | [
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0.0121... |
10,010,642 | Endometrial carcinoma in Miyagi Prefecture, Japan: histopathologic analysis of a cancer registry-based series and comparison with cases in American women. | [
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10,010,643 | Cases of endometrial carcinoma (104) from the Cancer Registry of Miyagi Prefecture, Japan, during the period from 1966--1977 have been reviewed histologically. The most impressive differences between tumors in this low-risk population and those reported in American women are higher frequencies of the mixed adenosquamou... | [
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10,010,644 | Delayed induction of ornithine decarboxylase in mouse skin after irradiation with beta-rays. | [
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10,010,645 | Irradiation with 90Sr-90Y beta rays induced ornithine decarboxylase (ODC) activity in mouse skin. Maximum activity appeared after about 17 days, at the time of appearance of skin injuries. These findings suggest the presence of tumor-promoting activity of beta rays. | [
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10,010,646 | Surface reduction of amorphous NiS particles potentiates their phagocytosis and subsequent induction of morphological transformation in Syrian hamster embryo cells. | [
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0.0565... |
10,010,647 | The incidence of morphological transformation following exposure of Syrian hamster embryo (SHE) cells to crystalline alphaNiS particles was considerably greater than that following a similar exposure to amorphous NiS particles. These differences in potency were attributable to the selective phagocytosis of crystalline ... | [
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0.0272544... |
10,010,648 | The induction of DNA strand breakage by nickel compounds in cultured Chinese hamster ovary cells. | [
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10,010,649 | Both NiCl2 and crystalline alphaNiS induced DNA strand breaks in cultured Chinese hamster ovary (CHO) cells. Alkaline sucrose gradient analysis of [3H]thymidine radiolabelled DNA isolated from cells exposed to NiCl2 at 1 microgram/ml for only 2 h indicated a high degree of DNA strand breakage. Similarly crystalline alp... | [
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10,010,650 | Enhancement of hyperthermia-induced cytotoxicity upon ATP deprivation. | [
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10,010,651 | The combined effects of hyperthermia and uncouplers of oxidative phosphorylation (dinitrophenol (DNP) or m-chlorocarbonylcyanide phenyl-hydrazone (CCCP) or 5-thio-d-glucose (5-TG) on mammalian cell survival were studied in vitro. Uncouplers were toxic towards cells treated under aerobic conditions at 41 degrees C, wher... | [
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10,010,652 | Diminished toxicity of methotrexate in CD2F1 mice pretreated with cycloheximide. | [
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10,010,653 | Cycloheximide at 100 mg/kg administered intraperitoneally to P388 tumor-bearing CD2F1 mice diminished protein synthesis in the liver, spleen, kidneys, lungs, small intestine and P388 tumor 75 min after administration. Six hours after administration all the above tissues except the tumor no longer demonstrated suppressi... | [
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10,010,654 | Effects of 12-O-tetradecanoylphorbol-13-acetate and mezerein on gamma radiation-induced DNA repair in resting bovine lymphocytes. | [
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0.00... |
10,010,655 | The present study was undertaken to determine the effect of the potent tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) on gamma radiation-induced DNA repair in resting (Go) lymphocytes. Mezerein, a non-promoter but a co-mitogen in lymphocytes, was used as a control agent. It was previously proposed that a po... | [
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10,010,656 | Effect of oxygen concentration on the growth and drug sensitivity of human melanoma cells in soft-agar clonogenic assay. | [
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10,010,657 | Tumor cells from a human melanoma xenograft show better colony growth and plating efficiency in soft agar when incubated in a 5% O2 atmosphere that at a higher concentration of 20% O2. Exposure to low drug concentrations under a 20% (but not 5%) O2 atmosphere stimulated plating efficiency. Enhanced sensitivity (4- to 2... | [
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10,010,658 | Quantitative dose-response relations for the cytotoxic activity of chloroethylnitrosoureas in cell culture. | [
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0.04240... |
10,010,659 | A dose-response relation for the cytotoxic activity of chloroethylnitrosourea cancer chemotherapeutic agents in cell culture has been developed. Data for the activity of 1,3-bis(2-chloroethyl)-1-nitrosourea, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea, 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea, and ... | [
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0.07138263434171677,
0.0314416... |
10,010,660 | Reduction of ethylnitrosourea-induced neoplastic proliferation in rat trigeminal nerves by nerve growth factor. | [
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10,010,661 | Ethylnitrosourea administered to pregnant rats on the 21st day of gestation at a dose of 50 mg/kg resulted in early neoplastic proliferation or neurinomas of trigeminal nerves in 90% of the offspring at 90 days of age. Treatment with nerve growth factor either postnatally following ethylnitrosourea administration or tr... | [
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0.0437... |
10,010,662 | Differences in anchorage-dependent growth and tumorigenicities between transformed C3H/10T 1/2 cells with morphologies that are or are not reverted to a normal phenotype by ascorbic acid. | [
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10,010,663 | C3H/10T 1/2 mouse embryo cells were transformed with 3-methylcholanthrene. Several type III morphologically transformed cell lines were selected with morphologies that either could or could not be reverted back to normal at passage 1 by daily addition of ascorbic acid (1 or 5 microgram/ml). Those transformed cell lines... | [
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10,010,664 | Differential effects of sodium butyrate, dimethyl sulfoxide, and retinoic acid on membrane-associated antigen, enzymes, and glycoproteins of human rectal adenocarcinoma cells. | [
0.017717111855745316,
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0.03... |
10,010,665 | The effects of sodium butyrate, dimethyl sulfoxide (DMSO), and retinoic acid on the growth, morphology, carcinoembryonic antigen content, cell surface membrane-associated enzyme activities, and glycoprotein profiles of a human rectal adenocarcinoma cell line (HRT-18) in culture were compared. All three agents reversibl... | [
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0.045448... |
10,010,666 | Cloning and screening of sequences expressed in a mouse colon tumor. | [
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10,010,667 | Polyadenylic acid-containing cytoplasmic RNA was isolated from a dimethylhydrazine-induced mouse transplantable colon carcinoma. Double-stranded complementary DNA synthesized using these molecules was inserted into the HindIII site of pBR322 using HindIII linkers, and the recombinant molecules were cloned in Escherichi... | [
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10,010,668 | Inactivation of S-adenosylhomocysteine hydrolase by 9-beta-D-arabinofuranosyladenine in intact cells. | [
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0.01... |
10,010,669 | The inactivation of S-adenosylhomocysteine (AdoHcy) hydrolase (EC 3.3.1.1) in isolated rat hepatocytes by 9-beta-D-arabinofuranosyladenine (ara-A) was associated with tight binding of ara-A to the enzyme and showed an initial phase obeying first-order kinetics characterized by Ki (concentration of half-maximal rate of ... | [
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0.08320873975753784,
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0... |
10,010,670 | Fecal mutagens in two Japanese populations with different colon cancer risks. | [
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0.006255540996789932,
0.0... |
10,010,671 | Human feces from 223 Japanese in Hawaii at high risk for colon cancer and feces from 166 Japanese of northern rural Japan at low risk for colon cancer were shown to contain mutagenic activity under five different test conditions. The first assay, using the Ames TA98 and TA100 Salmonella test, detected ether-soluble mut... | [
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0.015418571420013905,
0.0887... |
10,010,672 | Enzymology of pyrimidine and carbohydrate metabolism in human colon carcinomas. | [
0.04608158767223358,
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0.0... |
10,010,673 | Variability in hematoporphyrin derivative preparations. | [
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0.0036... |
10,010,674 | Retardation and promotion of growth of spontaneously appearing tumors using immune lymphocytes previously exposed to embryonic antigens. | [
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0.05202822387218475,
-0.025... |
10,010,675 | Spleen lymphocytes taken from mice at various stages of pregnancy or growth of s.c. syngeneic tumor implants have been examined for their ability to cause cytolysis of embryo fibroblasts in culture or to affect the growth of the transplanted tumor cells in vivo. Activity of different lymphoid populations in affecting t... | [
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0.035350408405065536,
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0.03013000637292862,
0.0... |
10,010,676 | Inhibition of mitosis and anticancer activity against experimental neoplasms by ethyl 5-amino-1,2-dihydro-3-[(N-methylanilino)methyl]-pyrido[3,4-b]pyrazin-7-ylcarbamate (NSC 181928). | [
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0.07339667528867722,
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0.01385... |
10,010,677 | Ethyl 5-amino-1,2-dihydro-3-[N-methylanilino)methyl]pyrido[3,4-b]pyrazin-7-ylcarbamate (NSC 181928) is reported to be active against several experimental neoplasms. The experimental data obtained in the present study indicate that it causes the accumulation of cells at mitosis with both cultured cells and ascites cance... | [
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0.04186983406543732,
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0.06004869565367699,
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10,010,678 | Interaction of rhodamine 123 with living cells studied by flow cytometry. | [
-0.06615275144577026,
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0.025781001895666122,
0.00... |
10,010,679 | The cationic fluorochrome rhodamine 123 (R123), reported to bind specifically to mitochondria of living cells, was presently investigated with respect to its uptake by a variety of cell types in various functional states and the subsequent effect of the dye on cell growth. The emission spectrum of R123 taken up by cell... | [
0.018416574224829674,
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0.0366847962141037,
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0.025031384080648422,
0.060914237052202225,
0.0248581... |
10,010,680 | Combined modality treatment using radiation and/or chemotherapy in an athymic nude mouse-human medulloblastoma and glioblastoma xenograft model. | [
0.009729208424687386,
0.022180361673235893,
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-0.008557917550206184,
-0.041311901062726974,
... |
10,010,681 | A human medulloblastoma (BN-2) and a glioblastoma (BN-3) which were previously established in nude mice were used to determine the effect of combined modality therapy with gamma-radiation, and three chemotherapeutic agents, procarbazine, 1,4-cyclohexadiene-1,4-dicarbamic acid, 2,5-bis(1-aziridinyl)-3,6-dioxo diethylest... | [
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0.021353989839553833,
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0.046318646520376205,
-0.02449873... |
10,010,682 | Altered amino acid kinetics in rats with progressive tumor growth. | [
0.07932148873806,
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0.020329808816313744,
0.04711443930864334,
0.065193310379982,
0.006972145289182663,
0.007536681368... |
10,010,683 | The present study was designed to determine whether alterations in host metabolism associated with progressive tumor growth were a result of the anorexia frequently observed with cancer or could be attributed to other direct tumor effects. Rates of tyrosine flux, oxidation, and incorporation into protein, as well as fr... | [
0.022052140906453133,
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0.06160905957221985,
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-... |
10,010,684 | Conversion of 4-hydroperoxycyclophosphamide and 4-hydroxycyclophosphamide to phosphoramide mustard and acrolein mediated by bifunctional catalysis. | [
0.012376177124679089,
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0.055144939571619034,
-... |
10,010,685 | The rates at which 4-hydroperoxycyclophosphamide and 4-hydroxycyclophosphamide are converted to phosphoramide mustard and acrolein were determined as a function of buffer composition, buffer concentration, and pH. Conversion of 4-hydroperoxycyclophosphamide to 4-hydroxycyclophosphamide in 0.5 M Tris buffer, pH 7.4, 37 ... | [
0.0394669733941555,
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10,010,686 | Effect of scheduling of combinations of 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide and 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea on the Harding-Passey and Cloudman S91 mouse melanomas. | [
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... |
10,010,687 | Harding-Passey mouse melanoma (HP) cells (10(6)) were administered i.p. to female BALB/c x DBA/2 F1 (hereafter called CD2F1) mice on Day 0. We showed earlier (H. Z. Hill, et al., Arch Surg., 114: 135-138, 1979) that a single dose of 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (DTIC) administered on Day 0 or on s... | [
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0... |
10,010,688 | Characterization of a human lung tumor-associated antigen and development of a radioimmunoassay. | [
0.025967661291360855,
0.08926799148321152,
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0.03199509158730507,
0.06994... |
10,010,689 | A human lung tumor-associated antigen (LTA), previously isolated from a small cell carcinoma, was further studied after labeling with N-succinimidyl-3-(4-hydroxy-5-[125I]iodophenyl)propionate. Two immunoreactive forms of the labeled antigen were observed and isolated after electrophoresis in 7% polyacrylamide gels. The... | [
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0.023000411689281464,
0.06688367575407028,
0.0791320... |
10,010,690 | Inactivation of ultraviolet repair in normal and xeroderma pigmentosum cells by methyl methanesulfonate. | [
0.03626026585698128,
0.01732526905834675,
0.0013929990818724036,
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0.03453461080789566,
0.011973140761256218,
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-0.0272... |
10,010,691 | Excision repair of ultraviolet damage in the DNA of normal and xeroderma pigmentosum (Groups C, D, and variant) cells was inactivated by exposure of cells to methyl methanesulfonate immediately before irradiation independent of the presence of 0 to 10% fetal calf serum. The inactivation could be represented by a semilo... | [
0.03753940016031265,
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0.02297227457165718,
0.004053187556564808,
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-0.01945948... |
10,010,692 | Effects of delays in the cell cycle on the induction of preneoplastic and neoplastic lesions in rat liver by 1,2-dimethylhydrazine. | [
0.04016178473830223,
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0.023149026557803154,
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0.039802104234695435,
0.08420871943235397,
-0.0... |
10,010,693 | This study was designed to explore further the relationship between cell proliferation and the induction of early putative preneoplastic lesions by carcinogens. Rats were given a non-necrogenic dose of 1,2-dimethylhydrazine 24 hr before being subjected to partial hepatectomy. Beginning 4 hr later, hydrocortisone was in... | [
0.05724445730447769,
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0.015552583150565624,
0.019988588988780975,
0.10478200763463974,
0.07173610478639603,
0.019... |
10,010,694 | "Hidden" cytotoxic antibodies that react with allogeneic cultured fetal and tumor cells contained in soluble immune complexes from normal human sera. | [
-0.029261808842420578,
0.004877524916082621,
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0.04172216355800629,
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0.035571351647377014,
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0.013531757518649101,
-... |
10,010,695 | Hidden complement-dependent cytotoxins were demonstrated in normal donor sera after removing anti-immunoglobulins that normally block the ability of these immunoglobulin Gs to react with surface antigens on tumor cells. The blocking antibodies had certain properties of anti-idiotypes. Immunoglobulin G from Cohn Fractio... | [
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0.005257238168269396,
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0.03479376435279846,
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10,010,696 | Expression of multimolecular forms of pyruvate kinase in normal, benign, and malignant human breast tissue. | [
-0.014659714885056019,
0.0064102341420948505,
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0.018323196098208427,
0.07295841723680496,
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0.... |
10,010,697 | The levels of multimolecular forms of pyruvate kinase present in four normal human breast specimens, nine benign tissues, and 13 malignant breast carcinomas were determined. The different enzymatic forms were separated by isoelectrofocusing, quantitated photometrically, and characterized further by kinetic studies usin... | [
-0.004577110055834055,
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0.05690078064799309,
0.004155580420047045,
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0.05608... |
10,010,698 | Increased induction of sister chromatid exchange by diethylstilbestrol in lymphocytes from pregnant and premenopausal women. | [
0.0002687710803002119,
0.005208506248891354,
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-0... |
10,010,699 | Cultures of whole blood from pregnant women (4 to 6 months), premenopausal women, postmenopausal women, and normal men were grown in the presence of varying concentrations (1 x 10(-5) M, 2 x 10(-5) M, and 4 x 10(-5) M) of diethylstilbestrol (DES), a synthetic estrogen and known carcinogen, to see if it had sex-related ... | [
0.0013032968854531646,
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0.00915804598480463,
0.014008898288011551,
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-0.018506646156311035,
-0.064... |
10,010,700 | Site-selective growth of a hormone-responsive human breast carcinoma in athymic mice. | [
0.04103349894285202,
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0.011897655203938484,
0.07782946527004242,
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0.04592331498861313,
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0.01187983900308609,
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-0.00659... |
10,010,701 | MCF-7 is a human breast cancer line which requires estradiol supplementation for growth in s.c. tissues of athymic mice. In order to evaluate the influence of host site on hormone-dependent tumorigenicity and growth, MCF-7 cells were inoculated into tissues varying in ability to concentrate exogenous estradiol. Tumorig... | [
0.03227107971906662,
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0.0013021692866459489,
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0.04229540750384331,
0.03156150504946709,
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0.01637231558561325,
0.0... |
10,010,702 | Lysis of fresh human solid tumors by autologous lymphocytes activated in vitro with lectins. | [
-0.023377491161227226,
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-0.00810800027102232,
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-0.01817568764090538,
-0.07821709662675858,
0.08388767391443253,
0.022654956206679344,
0.... |
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